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https://www.readbyqxmd.com/read/28529461/treatment-of-non-tuberculous-mycobacterial-lung-disease
#1
Julie V Philley, Mary Ann DeGroote, Jennifer R Honda, Michael M Chan, Shannon Kasperbauer, Nicholas D Walter, Edward D Chan
Treatment of non-tuberculous mycobacterial lung disease (NTM-LD) is challenging for several reasons including the relative resistance of NTM to currently available drugs and the difficulty in tolerating prolonged treatment with multiple drugs. Yet-to-be-done, large, multicenter, prospective randomized studies to establish the best regimens will also be arduous because multiple NTM species are known to cause human lung disease, differences in virulence and response to treatment between different species and strains within a species will make randomization more difficult, the need to distinguish relapse from a new infection, and the difficulty in adhering to the prescribed treatment due to intolerance, toxicity, and/or drug-drug interactions, often necessitating modification of therapeutic regimens...
December 2016: Current Treatment Options in Infectious Diseases
https://www.readbyqxmd.com/read/28509852/inhaled-antibiotic-therapy-in-chronic-respiratory-diseases
#2
REVIEW
Diego J Maselli, Holly Keyt, Marcos I Restrepo
The management of patients with chronic respiratory diseases affected by difficult to treat infections has become a challenge in clinical practice. Conditions such as cystic fibrosis (CF) and non-CF bronchiectasis require extensive treatment strategies to deal with multidrug resistant pathogens that include Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus, Burkholderia species and non-tuberculous Mycobacteria (NTM). These challenges prompted scientists to deliver antimicrobial agents through the pulmonary system by using inhaled, aerosolized or nebulized antibiotics...
May 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28506264/an-association-between-pulmonary-mycobacterium-avium-intracellulare-complex-infections-and-biomarkers-of-th2-type-inflammation
#3
Paul E Pfeffer, Susan Hopkins, Ian Cropley, David M Lowe, Marc Lipman
BACKGROUND: The rising incidence of pulmonary Mycobacterium avium-intracellulare complex (MAI) infection is unexplained but parallels the growing world-wide epidemic of allergic disease. We hypothesized an association between pulmonary MAI infection and Th2-type immune responses as seen in allergy. METHODS: Biomarkers of patient Th2-type immune responses (peripheral blood eosinophil counts and serum IgE levels) were compared between patients with positive pulmonary samples for tuberculosis and non-tuberculous mycobacterial (NTM) infection...
May 15, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28504926/accurate-differentiation-of-mycobacterium-chimaera-from-mycobacterium-intracellulare-by-maldi-tof-ms-analysis
#4
Arthur B Pranada, Ellen Witt, Michael Bienia, Markus Kostrzewa, Markus Timke
PURPOSE: The increasing number of infections caused by nontuberculous mycobacteria (NTM) has prompted the need for rapid and precise identification methods of these pathogens. Several studies report the applicability of MALDI-TOF mass spectrometry (MS) for identification of NTM. However, some closely related species have very similar spectral mass fingerprints, and until recently, Mycobacterium chimaera and M. intracellulare could not be separated from each other by MALDI-TOF MS. METHODOLOGY: The conventional identification methods used in routine diagnostics have similar limitations...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28486537/association-between-a-history-of-mycobacterial-infection-and-the-risk-of-newly-diagnosed-sj%C3%A3-gren-s-syndrome-a-nationwide-population-based-case-control-study
#5
Wen-Cheng Chao, Ching-Heng Lin, Tsai-Ling Liao, Yi-Ming Chen, Der-Yuan Chen, Hsin-Hua Chen
OBJECTIVE: To address the association between a history of tuberculosis (TB) or nontuberculous mycobacterial (NTM) infection and the risk of newly diagnosed Sjögren's syndrome (SS). METHODS: Using a nationwide, population-based, claims dataset, and after excluding those who had rheumatoid arthritis or systemic lupus erythematosus, we identified 5,751 newly diagnosed SS cases during 2007-2012, and compared them to 86,265 non-SS controls matched (1:15) for age, sex, and the year of first SS diagnosis date...
2017: PloS One
https://www.readbyqxmd.com/read/28483608/safety-and-effectiveness-of-clofazimine-for-primary-and-refractory-nontuberculous-mycobacterial-infection
#6
Stacey L Martiniano, Brandie D Wagner, Adrah Levin, Jerry A Nick, Scott D Sagel, Charles L Daley
BACKGROUND: Clofazimine is an antimicrobial agent that has activity in vitro against mycobacteria. Increasingly, it has been used for the treatment of nontuberculous mycobacteria (NTM), despite limited data supporting use in this setting. The objective of this study was to evaluate safety, tolerability, and clinical outcomes associated with clofazimine in patients with NTM infection. METHODS: Observational-cohort study of clofazimine used for pediatric and adult cystic fibrosis (CF) and non-CF patients with pulmonary and extrapulmonary NTM infection as part of a multidrug regimen from 2006-2014...
May 5, 2017: Chest
https://www.readbyqxmd.com/read/28479113/pharmacotherapy-for-non-cystic-fibrosis-bronchiectasis-results-from-an-ntm-info-research-patient-survey-and-the-bronchiectasis-and-ntm-research-registry
#7
E Henkle, T R Aksamit, A F Barker, J R Curtis, C L Daley, M L Daniels, A DiMango, E Eden, K Fennelly, D E Griffith, M Johnson, M R Knowles, A Leitman, P Leitman, E Malanga, M L Metersky, P G Noone, A E O'Donnell, K N Olivier, D Prieto, M Salathe, B Thomashow, G Tino, G Turino, S Wisclenny, K L Winthrop
PURPOSE: Non-cystic fibrosis bronchiectasis ("bronchiectasis") is a chronic inflammatory lung disease often associated with nontuberculous mycobacterium (NTM) infection. Very little data exist to guide bronchiectasis management decisions. We sought to describe patterns of inhaled corticosteroid (ICS) and antibiotic therapy in the U.S. METHODS: We invited 2,000 patients through NTM Info & Research (NTMir) to complete an anonymous electronic survey. We separately queried baseline clinical and laboratory data from the U...
May 4, 2017: Chest
https://www.readbyqxmd.com/read/28471978/septicemia-and-pneumonia-due-to-mycobacterium-fortuitum-infection-in-a-patient-with-extronodal-nk-t-cell-lymphoma-nasal-type-a-case-report
#8
Jia Cong, Chenxi Wang, Li Ma, Shaoya Zhang, Jingwen Wang
RATIONALE: Mycobacterium fortuitum (M.fortuitum) is one of the rapidly growing nontuberculous mycobacterium (NTM) that is widespread in the environment. M.fortuitum can cause different types of disease including pulmonary disease, lymphadenitis, cutaneous disease, and disseminated disease. However, the infection presenting as septicemia is exceedingly rare. PATIENT CONCERNS: A 48-year-old immunocompromised male with extranodal NK/T-cell lymphoma, nasal type was admitted to the hospital because of high fever for 10 days...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28437431/factors-associated-with-acquired-anti-ifn-%C3%AE-autoantibody-in-patients-with-nontuberculous-mycobacterial-infection
#9
Pakpoom Phoompoung, Nasikarn Ankasekwinai, Manop Pithukpakorn, Suporn Foongladda, Pinklow Umrod, Bhoom Suktitipat, Surakameth Mahasirimongkol, Sasisopin Kiertiburanakul, Yupin Suputtamongkol
BACKGROUND: The clinical syndrome of disseminated nontuberculous mycobacterial (NTM) infection in patients who were previously healthy is now well recognized to be associated with an acquired autoantibody to Interferon gamma (Anti IFN- γ autoantibody). However, the risk factors of this syndrome remain unknown. METHOD: We performed an unmatched case control study among patients with NTM diseases who were diagnosed and treated at Siriraj Hospital, Bangkok, Thailand...
2017: PloS One
https://www.readbyqxmd.com/read/28430999/repurposing-quantiferon-for-detection-of-neutralizing-ifn-%C3%AE-autoantibodies-in-patients-with-nontuberculous-mycobacterial-infections
#10
Isabelle Suárez, Clara Lehmann, Henning Gruell, Jessica Graeb, Matthias Kochanek, Gerd Fätkenheuer, Georg Plum, Annelies van Wengen, Esther van de Vosse, Pia Hartmann, Leif G Hanitsch, Jan Rybniker
Nontuberculous mycobacterial (NTM) infections due to autoantibodies targeting IFN-γ are an emerging medical problem. However, case finding is hampered due to highly complex diagnostic procedures not available in routine laboratories. We show that QuantiFERON assays can be exploited as a simple screening tool that may facilitate adequate and timely treatment.
April 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28423372/patterns-of-disease-in-patients-with-middle-lobe-predominant-bronchiectasis
#11
Melissa J McDonnell, Mohammed Ahmed, Jeeban Das, Michael O'Mahony, David Breen, Anthony O'Regan, J J Gilmartin, John Bruzzi, Robert M Rutherford
BACKGROUND: Middle-lobe predominant bronchiectasis affecting the right middle-lobe and/or lingula (RMLP) is classically described in asthenic, elderly females with skeletal abnormalities or associated nontuberculous mycobacterial (NTM) infection. OBJECTIVES: We aimed to evaluate the frequency and clinical characteristics of patients with an RMLP phenotype in a cohort of newly diagnosed bronchiectasis patients and determine associations with disease severity. METHODS: A retrospective observational cross-sectional cohort study of consecutive bronchiectasis patients in our institution was performed...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28422568/cgas-sting-tbk1-irf3-7-induced-interferon-%C3%AE-contributes-to-the-clearing-of-non-tuberculous-mycobacterial-infection-in-mice
#12
Nanthapon Ruangkiattikul, Andreas Nerlich, Ketema Abdissa, Stefan Lienenklaus, Abdulhadi Suwandi, Nina Janze, Kristin Laarmann, Julia Spanier, Ulrich Kalinke, Siegfried Weiss, Ralph Goethe
Type I interferons (IFN-I), such as IFN-α and IFN-β are important messengers in the host response against bacterial infections. Knowledge about the role of IFN-I in infections by nontuberculous mycobacteria (NTM) is limited. Here we show that macrophages infected with pathogens of the Mycobacterium avium complex produced significantly lower amounts of IFN-β than macrophages infected with the opportunistic pathogen M. smegmatis. To dissect the molecular mechanisms of this phenomenon, we focused on the obligate pathogen Mycobacterium avium ssp paratuberculosis (MAP) and the opportunistic M...
April 19, 2017: Virulence
https://www.readbyqxmd.com/read/28418290/invasive-nontuberculous-mycobacterial-infections-among-cardiothoracic-surgical-patients-exposed-to-heater-cooler-devices-1
#13
Meghan M Lyman, Cheri Grigg, Cara Bicking Kinsey, M Shannon Keckler, Heather Moulton-Meissner, Emily Cooper, Minn M Soe, Judith Noble-Wang, Allison Longenberger, Shane R Walker, Jeffrey R Miller, Joseph F Perz, Kiran M Perkins
Invasive nontuberculous mycobacteria (NTM) infections may result from a previously unrecognized source of transmission, heater-cooler devices (HCDs) used during cardiac surgery. In July 2015, the Pennsylvania Department of Health notified the Centers for Disease Control and Prevention (CDC) about a cluster of NTM infections among cardiothoracic surgical patients at 1 hospital. We conducted a case-control study to identify exposures causing infection, examining 11 case-patients and 48 control-patients. Eight (73%) case-patients had a clinical specimen identified as Mycobacterium avium complex (MAC)...
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28416955/down-regulation-of-serum-high-mobility-group-box-1-protein-in-patients-with-pulmonary-tuberculosis-and-nontuberculous-mycobacterial-lung-disease
#14
Su-Young Kim, Won-Jung Koh, Hye Yun Park, Kyeongman Jeon, Soo-Youn Lee, Jae-Joon Yim, Sung Jae Shin
BACKGROUND: Recently, increased levels of high-mobility group box 1 protein (HMGB1) have been identified in various inflammatory conditions and infections. However, no studies have evaluated the HMGB1 level in nontuberculous mycobacterial (NTM) lung disease, and compared it to mycobacterial lung disease. METHODS: A total of 60 patients newly diagnosed with NTM lung disease, 44 culture-positive pulmonary tuberculosis (TB) patients, and 34 healthy controls, were included in this study...
April 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28406709/long-term-outcomes-in-a-population-based-cohort-with-respiratory-nontuberculous-mycobacteria-isolation
#15
Emily Henkle, Shannon A Novosad, Sean Shafer, Katrina Hedberg, Sarah A R Siegel, Jennifer Ku, Cara Varley, D Rebecca Prevots, Theodore K Marras, Kevin L Winthrop
RATIONALE: The natural history of nontuberculous mycobacterial (NTM) respiratory infection within the general population is poorly understood. OBJECTIVES: To describe the long-term clinical, microbiologic, and radiographic outcomes of patients with respiratory NTM isolates. METHODS: We previously identified a population-based cohort of patients with respiratory NTM isolation during 2005-6, and categorized patients as cases or non-cases using the ATS/IDSA pulmonary NTM disease criteria at that time...
April 13, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28400668/nontuberculous-mycobacterial-infection-of-the-musculoskeletal-system-in-immunocompetent-hosts
#16
Manit K Gundavda, Hitendra G Patil, Vikas M Agashe, Rajeev Soman, Camilla Rodriques, Ramesh B Deshpande
BACKGROUND: Nontuberculous mycobacteria (NTM) were considered saprophytic organisms for many years but now are recognized as human pathogens. Although humans are routinely exposed to NTM, the rate of clinical infection is low. Such infections usually occur in the elderly and in patients who are immunocompromised. However, there has been an increasing incidence in recent years of infections in immunocompetent hosts. NTM infections in immunocompetent individuals are secondary to direct inoculation either contamination from surgical procedures or penetrating injuries rather than hematogenous dissemination...
March 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28393860/mycobacterium-llatzerense-a-waterborne-mycobacterium-that-resists-phagocytosis-by-acanthamoeba-castellanii
#17
Vincent Delafont, Ascel Samba-Louaka, Emmanuelle Cambau, Didier Bouchon, Laurent Moulin, Yann Héchard
Nontuberculous mycobacteria (NTM) are environmental bacteria increasingly associated to public health problems. In water systems, free-living amoebae (FLA) feed on bacteria by phagocytosis, but several bacteria, including many NTM, are resistant to this predation. Thus, FLA can be seen as a training ground for pathogenic bacteria. Mycobacterium llatzerense was previously described as frequently associated with FLA in a drinking water network. The present study aimed to characterize the interactions between M...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28387532/mortality-after-respiratory-isolation-of-nontuberculous-mycobacteria-a-comparison-of-patients-who-did-and-did-not-meet-disease-criteria
#18
Shannon A Novosad, Emily Henkle, Sean Schafer, Katrina Hedberg, Jennifer Ku, Sarah A R Siegel, Dongseok Choi, Christopher G Slatore, Kevin L Winthrop
RATIONALE: The mortality of patients with respiratory tract isolates of nontuberculous mycobacteria (NTM) and their risk factors for death are not well described . OBJECTIVES: This study had two objectives: 1) to determine age-adjusted mortality rates for patients with respiratory NTM isolates and their causes of death; and 2) to examine whether ATS/IDSA diagnostic criteria identify those at higher risk of death after NTM isolation. METHODS: We linked vital records registries with a previously identified Oregon populationbased cohort of patients with NTM respiratory isolation...
April 7, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28387523/species-specific-risk-factors-treatment-decisions-and-clinical-outcomes-for-laboratory-isolates-of-less-common-nontuberculous-mycobacteria-in-washington-state
#19
Emily S Ford, David J Horne, Javeed A Shah, Carolyn K Wallis, Ferric C Fang, Thomas R Hawn
RATIONALE: Nontuberculous mycobacteria are a diverse group of environmental organisms that infrequently cause human disease. Understanding the epidemiologic and clinical characteristics associated with nontuberculous mycobacterial disease is needed to refine diagnostic and treatment strategies, particularly among the less commonly isolated species. OBJECTIVES: To improve knowledge of geographic variance of nontuberculous mycobacteria (NTM) species, to correlate detailed clinical information with isolation of specific NTM, and to examine the decision to treat and outcomes for specific NTM...
April 7, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28387180/mycobacterium-marinum
#20
Alexandra Aubry, Faiza Mougari, Florence Reibel, Emmanuelle Cambau
Mycobacterium marinum is a well-known pathogenic mycobacterium for skin and soft tissue infections and is associated with fishes and water. Among nontuberculous mycobacteria (NTM), it is the leading cause of extrarespiratory human infections worldwide. In addition, there is a specific scientific interest in M. marinum because of its genetic relatedness to Mycobacterium tuberculosis and because experimental infection of M. marinum in fishes mimics tuberculosis pathogenesis. Microbiological characteristics include the fact that it grows in 7 to 14 days with photochromogenic colonies and is difficult to differentiate from Mycobacterium ulcerans and other mycolactone-producing NTM on a molecular basis...
April 2017: Microbiology Spectrum
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