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https://www.readbyqxmd.com/read/29126235/clinical-significance-of-interferon-%C3%AE-neutralizing-autoantibodies-against-disseminated-nontuberculous-mycobacterial-disease
#1
Ami Aoki, Takuro Sakagami, Kazutaka Yoshizawa, Kenjiro Shima, Mio Toyama, Yoshinari Tanabe, Hiroshi Moro, Nobumasa Aoki, Satoshi Watanabe, Toshiyuki Koya, Takashi Hasegawa, Kozo Morimoto, Atsuyuki Kurashima, Yoshihiko Hoshino, Bruce C Trapnell, Toshiaki Kikuchi
Background: Interferon-γ neutralizing autoantibodies (nIFNγ-autoAb) are reported in patients with disseminated nontuberculous mycobacteria (NTM) infection and may function by increasing the infection risk. Notwithstanding, the prevalence of nIFNγ-autoAb as well as the clinical presentation, diagnosis, and natural history, of disseminated NTM infection in these patients is poorly understood. Methods: In this retrospective observational study, data and sera for 331 Japanese subjects with mycobacterial infection were collected and analyzed...
November 8, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29109708/differential-identification-of-mycobacterial-species-using-high-resolution-melting-analysis
#2
Azar D Khosravi, Mohammad Hashemzadeh, Abdolrazagh Hashemi Shahraki, Ali Teimoori
Infections caused by non-tuberculous mycobacteria (NTM) is increasing wordwide. Due to the difference in treatment of NTM infections and tuberculosis, rapid species identification of mycobacterial clinical isolates is necessary for the effective management of mycobacterial diseases treatment and their control strategy. In this study, a cost-effective technique, real-time PCR coupled with high-resolution melting (HRM) analysis, was developed for the differentiation of Mycobacterial species using a novel rpoBC sequence...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29092717/routinely-detected-indicators-in-plasma-have-a-predictive-effect-on-the-identification-of-hiv-infected-patients-with-non-tuberculous-mycobacterial-and-tuberculous-infections
#3
Ren-Tian Cai, Feng-Xue Yu, Zhen Tao, Xue-Qin Qian, Jun Chen, Hong-Zhou Lu
BACKGROUND: It is difficult to quickly distinguish non-tuberculous mycobacterial (NTM) infection from tuberculosis (TB) infection in human immunodeficiency virus (HIV)-infected patients because of many similarities between these diseases. A simple and effective way to determine the differences using routine blood tests is necessary in developing countries. METHODS: A retrospective cohort study was conducted to recruit HIV-infected patients with either NTM infection or TB infection diagnosed for the first time according to mycobacterial culture and microscopic identification from May 2010 to March 2016...
November 2, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29076443/-a-toddler-with-a-red-swelling-in-the-neck
#4
S Willemse, M Oomens, L Karssemakers, J de Lange
BACKGROUND: The differential diagnosis in a child with a swelling in the neck is broad. Chronic lymphadenopathy in children quite often leads to extensive blood tests. Cervicofacial non-tuberculous mycobacterial (NTM) lymphadenitis is, however, not revealed by blood tests. It is a rare condition, which is mostly seen in young children. CASE DESCRIPTION: A 4-year-old girl had a 9-week history of a swelling in her neck; the skin covering the swelling had been red and flaking for the past week...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29071482/-nontuberculous-mycobacterial-infections
#5
REVIEW
A Nowag, M Platten, G Plum, P Hartmann
Nontuberculous mycobacterial (NTM) are found ubiquitously in the environment and are usually of low pathogenicity. Infection occurs via inhalation of aerosols, and some species may cause severe infections. The incidence of NTM infections is rising worldwide. The risk of developing NTM disease depends on the susceptibility of the host as well as the frequency and duration of exposure. In addition to congenital immune deficiencies and immunosuppressive therapy, structural lung and systemic diseases, including rheumatoid arthritis (RA), are associated with an increased risk for NTM infections...
November 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29067624/are-guidelines-on-the-management-of-non-tuberculous-mycobacteria-lung-infections-respected-and-what-are-the-consequences-for-patients-a-french-retrospective-study-from-2007-to-2014
#6
N El-Zeenni, S Chanoine, C Recule, J-P Stahl, M Maurin, B Camara
Diagnosis and treatment of lung infections caused by non-tuberculous mycobacteria (NTM) remain challenging. Adherence of the clinicians to the American Thoracic Society (ATS) and the Infectious Diseases Society of America (IDSA) 2007 guidelines is often incomplete. Between 2007 and 2014, in Grenoble Alpes University Hospital, France, 132 patients had NTM-positive cultures from lower respiratory tract (LRT) samples. We retrospectively collected diagnosis, treatment, and outcome data of patients, and evaluated the adherence of clinicians to ATS/IDSA guidelines and the consequences of patients' prognoses...
October 24, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29054887/introducing-the-new-bts-guideline-management-of-non-tuberculous-mycobacterial-pulmonary-disease-ntm-pd
#7
EDITORIAL
Charles S Haworth, R Andres Floto
The new BTS Guidelines for the management of non-tuberculous mycobacterial pulmonary disease combine the best available evidence with expert consensus to generate a set of pragmatic Guidelines, published as a supplement to this issue of Thorax, to assist in the management of these challenging infections.
November 2017: Thorax
https://www.readbyqxmd.com/read/29040079/identification-of-nontuberculous-mycobacteria-isolated-from-hospital-water-by-sequence-analysis-of-the-hsp65-and-16s-rrna-genes
#8
Mehdi Roshdi Maleki, Hossein Samadi Kafil, Naser Harzandi, Seyyed Reza Moaddab
Nontuberculous mycobacteria (NTM) have emerged as an important cause of opportunistic nosocomial infections. NTM has frequently been isolated from hospital water distribution systems. The aim of this study was to survey the risk of NTM infections and determine the prevalence of NTM species in the hospital water distribution systems in Tabriz, Iran. One hundred and twenty samples of water from different sources of Tabriz hospitals were collected. The samples were filtered through 0.45-µm pore size membranes and decontaminated with 0...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29040071/prevalence-and-direct-costs-of-emergency-department-visits-and-hospitalizations-for-selected-diseases-that-can-be-transmitted-by-water-united-states
#9
E A Adam, S A Collier, K E Fullerton, J W Gargano, M J Beach
National emergency department (ED) visit prevalence and costs for selected diseases that can be transmitted by water were estimated using large healthcare databases (acute otitis externa, campylobacteriosis, cryptosporidiosis, Escherichia coli infection, free-living ameba infection, giardiasis, hepatitis A virus (HAV) infection, Legionnaires' disease, nontuberculous mycobacterial (NTM) infection, Pseudomonas-related pneumonia or septicemia, salmonellosis, shigellosis, and vibriosis or cholera). An estimated 477,000 annual ED visits (95% CI: 459,000-494,000) were documented, with 21% (n = 101,000, 95% CI: 97,000-105,000) resulting in immediate hospital admission...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29038903/-nontuberculous-mycobacteria-in-sputum-recommendations-for-diagnosis-and-treatment
#10
REVIEW
J Rademacher
Pulmonary diseases caused by nontuberculous mycobacteria (NTM) have increased over the last years and decades in Germany and also worldwide. Because the disease is more frequent in patients with immunodeficiencies and chronic respiratory diseases, e.g. bronchiectasis, advanced chronic obstructive lung disease (COPD) and cystic fibrosis (CF), an infection with mycobacteria should always be considered in this patient group. The detection in sputum alone is not an indication for treatment but the correct diagnosis should be based on the appropriate clinical symptoms as well as radiological and microbiological criteria...
November 2017: Der Internist
https://www.readbyqxmd.com/read/29033435/clinical-features-of-nontuberculous-mycobacterial-pleurisy-a-review-of-12-cases
#11
Maiko Naito, Toshiya Maekura, Yu Kurahara, Masahiro Tahara, Naoya Ikegami, Yohei Kimura, Shoko Sonobe, Takehiko Kobayashi, Shojiro Minomo, Taisuke Tsuji, Kazunari Tsuyuguchi, Seiji Hayashi, Katsuhiro Suzuki
Objective The incidence of pulmonary nontuberculous mycobacterial (NTM) infections has increased in recent decades. Nevertheless, NTM pleurisy is still a rare disease. The objective of the present study was to elucidate the clinical features and outcomes of NTM pleurisy. Methods A retrospective study was undertaken of consecutive patients whose pleural effusion culture yielded NTM, from 2002 to 2016 at a respiratory hospital in Japan. The clinical features, treatment, and outcomes of these patients were analyzed...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28988958/mycobacterium-abscessus-and-massiliense-lung-infection-during-macrolide-treatment-for-bronchiolitis-obliterans-after-allogeneic-hematopoietic-stem-cell-transplantation
#12
Noriko Miyake, Yong Chong, Ruriko Nishida, Katsuto Takenaka, Koji Kato, Toshihiro Miyamoto, Akio Aono, Akiko Takaki, Satoshi Mitarai, Shinji Shimoda, Nobuyuki Shimono, Koichi Akashi
In patients undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT), post-transplant lung infection is critical for their prognosis. Mycobacterium abscessus complex is not fully recognized as a nontuberculous mycobacteria (NTM) pathogen of post-SCT lung infection. Here, we present three post-allogeneic SCT patients who developed pulmonary infection caused by M. abscessus complex including M. abscessus and M. massiliense. In all three cases, macrolide antibiotics had been administered for bronchiolitis obliterans syndrome (BOS) before the confirmation of their infection, and macrolide resistance was noted in the M...
October 5, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28986190/incidence-and-risk-factors-for-nontuberculous-mycobacterial-infection-after-allogeneic-hematopoietic-cell-transplantation
#13
Jennifer Beswick, Elizabeth Shin, Fotios Michelis, Santhosh Thyagu, Auro Viswabandya, Jeffrey H Lipton, Hans Messner, Theodore K Marras, Dennis Dong Hwan Kim
Allogenic hematopoietic stem cell transplant (HCT) recipients are at risk of many infections. Nontuberculous mycobacteria (NTM) are increasingly recognized as clinically significant pathogens in this population. We investigated the incidence and risk factors for NTM infection after allogeneic HCT. This retrospective cohort study included all patients with allogeneic HCT at our institution during 2001 to 2013. Patients who developed significant NTM infection (NTM disease) were identified. Multivariable modeling was used to identify risk factors for NTM disease, and a risk score model was constructed to identify high-risk patients...
October 3, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28971307/non-tuberculous-mycobacterium-bacteraemia-in-a-pregnant-systemic-lupus-erythematosus-sle-patient-a-case-review-and-pooled-case-analysis
#14
REVIEW
Syahrul Sazliyana Shaharir, Narisa Sulaiman Sahari, Zeena Mohamed Fuad, Wan Zul Haikal Wan Zukiman, Nurul Hafizah Mohd Yusof, Anita Sulong, Petrick Periasamy
Non-tuberculous mycobacteria (NTM) are recognized as an important cause of human diseases and infections. It is commonly known to cause infections of the skin, soft tissue infections, and pulmonary infection as well as bacteraemia. We report a challenging case of severe mycobacterium abscessus bacteraemia in a pregnant lady with active systemic lupus erythematous (SLE). A comprehensive literature review of NTM infection among SLE patients was also performed, and pooled analysis of the reported cases, including our case, was done to determine the clinical characteristics and factors associated with poor outcome of NTM infection...
October 3, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28967797/pulmonary-disease-by-non-tuberculous-mycobacteria-clinical-management-unmet-needs-and-future-perspectives
#15
Lars-Olof Larsson, Eva Polverino, Wouter Hoefsloot, Luigi R Codecasa, Roland Diel, Stephen G Jenkins, Michael R Loebinger
The number of patients with pulmonary disease caused by non-tuberculous mycobacteria (NTM) is increasing globally. Poor resistance against infections, for example, due to pre-existing lung diseases, immune deficiency and immune-modulating treatment, predisposes the population to developing pulmonary NTM disease. The incidence of pre-existing lung diseases such as chronic obstructive pulmonary disease and bronchiectasis has also increased. NTM disease diagnosis is often delayed due to non-specific symptoms. The therapeutic arsenal is limited and adherence to treatment guidelines is often low since the treatment regimens are complex, lengthy and side effects are common...
October 10, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28957340/body-habitus-in-patients-with-and-without-bronchiectasis-and-non-tuberculous-mycobacteria
#16
Michael D Schweitzer, Oriana Salamo, Michael Campos, Dean E Schraufnagel, Ruxana Sadikot, Mehdi Mirsaeidi
BACKGROUND: Female gender, tall stature, presence of bronchiectasis are associated with pulmonary nontuberculous mycobacterial (NTM) infections. The biologic relationship between the body habitus and NTM infection is not well defined and the body habitus profile of the patients with NTM and concurrent bronchiectasis is completely unknown. METHODS: We conducted a case control study at the Miami VA Healthcare System and the University of Illinois Medical Center on patients with pulmonary NTM infections between 2010 and 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28931659/the-risk-of-mycobacterial-infections-associated-with-inhaled-corticosteroid-use
#17
Sarah K Brode, Michael A Campitelli, Jeffrey C Kwong, Hong Lu, Alex Marchand-Austin, Andrea S Gershon, Frances B Jamieson, Theodore K Marras
Inhaled corticosteroid (ICS) use is associated with an increased risk of pneumonia. This study was performed to determine if ICS use is associated with an increased risk of nontuberculous mycobacterial pulmonary disease (NTM-PD) or tuberculosis (TB).We conducted a population-based nested case-control study using linked laboratory and health administrative databases in Ontario, Canada, including adults aged ≥66 years with treated obstructive lung disease (i.e. asthma, chronic obstructive pulmonary disease (COPD) or asthma-COPD overlap syndrome) between 2001 and 2013...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28930014/surveillance-of-extrapulmonary-nontuberculous-mycobacteria-infections-oregon-usa-2007-2012
#18
Emily Henkle, Katrina Hedberg, Sean D Schafer, Kevin L Winthrop
Limited data are available describing extrapulmonary nontuberculous mycobacteria (NTM) infections in the general population. We describe results from statewide population-based laboratory surveillance in Oregon, USA, during 2007-2012. We defined a case of extrapulmonary NTM infection as >1 isolate from skin/soft tissue, disseminated sites, lymph node, joint, or other sites. The annual incidence of extrapulmonary NTM infection (other than Mycobacterium gordonae) was stable, averaging 1.5 cases/100,000 population...
October 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28923675/respiratory-infections-due-to-nontuberculous-mycobacterias
#19
REVIEW
Luis Máiz Carro, Esther Barbero Herranz, Rosa Nieto Royo
The most common infections caused by nontuberculous mycobacteria (NTM) are lung infections. The microorganisms causing these infections most frequently are Mycobacterium avium complex, Mycobacterium kansasii and Mycobacterium abscessus complex. Their incidence has increased in the last three decades. After identifying an NTM in the respiratory tract, clinical and radiological aspects must be considered to determine if isolations are clinically relevant. Predisposing conditions that could contribute to infection must also be investigated...
September 15, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28919618/molecular-detection-and-differentiation-of-mycobacterium-tuberculosis-complex-and-non-tuberculous-mycobacterium-in-the-clinical-specimens-by-real-time-pcr
#20
M M Rahman, M R Rahim, A Khaled, T A Nasir, F Nasrin, M A Hasan
Mycobacteria are subdivided into three groups: the Mycobacterium tuberculosis complex, the non-tuberculous mycobacteria called NTM or MOTT (Mycobacteria Other Than Tuberculosis) and Mycobacterium leprae. Over the past few decades, the incidence of infections caused by NTM has increased world wide. The differentiation of Mycobacterium tuberculosis complex from NTM is of primary importance for infection control and choice of antimicrobial therapy. However, there is so far no report in Bangladesh about the detection of NTM and hence differentiation of MTB and NTM...
July 2017: Mymensingh Medical Journal: MMJ
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