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https://www.readbyqxmd.com/read/28919618/molecular-detection-and-differentiation-of-mycobacterium-tuberculosis-complex-and-non-tuberculous-mycobacterium-in-the-clinical-specimens-by-real-time-pcr
#1
M M Rahman, M R Rahim, A Khaled, T A Nasir, F Nasrin, M A Hasan
Mycobacteria are subdivided into three groups: the Mycobacterium tuberculosis complex, the non-tuberculous mycobacteria called NTM or MOTT (Mycobacteria Other Than Tuberculosis) and Mycobacterium leprae. Over the past few decades, the incidence of infections caused by NTM has increased world wide. The differentiation of Mycobacterium tuberculosis complex from NTM is of primary importance for infection control and choice of antimicrobial therapy. However, there is so far no report in Bangladesh about the detection of NTM and hence differentiation of MTB and NTM...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28915071/transcriptional-response-of-respiratory-epithelium-to-nontuberculous-mycobacteria
#2
Masashi Matsuyama, Andrew J Martins, Shamira Shallom, Olena Kamenyeva, Anuj Kashyap, Elizabeth P Sampaio, Juraj Kabat, Kenneth N Olivier, Adrian M Zelazny, John S Tsang, Steven M Holland
RATIONALE: The incidence of pulmonary nontuberculous mycobacterial (PNTM) disease is increasing, but host responses in respiratory epithelium infected with NTM are not fully understood. OBJECTIVE: We aimed to identify infection-relevant gene expression signatures of NTM infection of the respiratory epithelium. METHODS: We infected air-liquid interface (ALI) primary respiratory epithelial cell cultures with Mycobacterium avium subsp. avium (MAC) or Mycobacterium abscessuss subsp...
September 15, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28893193/light-emitting-diode-fluorescent-microscopy-and-xpert-mtb-rif%C3%A2-assay-for-diagnosis-of-pulmonary-tuberculosis-among-patients-attending-ambo-hospital-west-central-ethiopia
#3
Alemu Gadissa Gelalcha, Abebaw Kebede, Hassen Mamo
BACKGROUND: The relatively simple and cheaper light-emitting diode fluorescent microscopy (LED-FM) was recommended by the World Health Organization (WHO) to replace the conventional tuberculosis (TB) microscopy in both high- and low-volume laboratories. More recently the WHO also endorsed one more technique, Xpert MTB/RIF® assay (Xpert), for improved TB diagnosis particularly among human immunodeficiency virus (HIV)-infected cases. However, the relative performance of both of these tools differs from setting to setting in reference to the conventional TB diagnostics...
September 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28874378/mycobacterium-abscessus-whib7-regulates-a-species-specific-repertoire-of-genes-to-confer-extreme-antibiotic-resistance
#4
Kelley Hurst-Hess, Paulami Rudra, Pallavi Ghosh
Mycobacterium abscessus causes acute and chronic broncho-pulmonary infection in patients with chronic lung damage, of which cystic fibrosis (CF) patients are particularly vulnerable. The major threat posed by this organism is its high intrinsic antibiotic resistance. A typical treatment regimen involves a 6-12 month long combination therapy of clarithromycin and amikacin, with cure rates below 50% and multiple side effects, especially due to amikacin. In the present work we show that M. abscessuswhiB7, a homologue of M...
September 5, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28861054/screening-of-tb-actives-for-activity-against-nontuberculous-mycobacteria-delivers-high-hit-rates
#5
Jian Liang Low, Mu-Lu Wu, Dinah Binte Aziz, Benoît Laleu, Thomas Dick
The prevalence of lung disease due to infections with nontuberculous mycobacteria (NTM) has been increasing and surpassed tuberculosis (TB) in some countries. Treatment outcomes are often unsatisfactory, highlighting an urgent need for new anti-NTM medications. Although NTM in general do not respond well to TB specific drugs, the similarities between NTM and Mycobacterium tuberculosis at the molecular and cell structural level suggest that compound libraries active against TB could be leveraged for NTM drug discovery...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28855835/distribution-of-non-tuberculosis-mycobacteria-strains-from-suspected-tuberculosis-patients-by-heat-shock-protein-65-pcr-rflp
#6
Ali Nour-Neamatollahie, Nayereh Ebrahimzadeh, Seyed Davar Siadat, Farzam Vaziri, Mona Eslami, Abbas Akhavan Sepahi, Sharareh Khanipour, Morteza Masoumi, Fatemeh Sakhaee, Morteza Ghazanfari Jajin, Ahmadreza Bahrmand, Abolfazl Fateh
The genus Mycobacterium contains more than 150 species. Non-tuberculosis mycobacteria (NTM) often cause extrapulmonary and pulmonary disease. Mycobacteria detection at species level is necessary and provides useful information on epidemiology and facilitates successful treatment of patients. This retrospective study aimed to determine the incidence of the NTM isolates and Mycobacterium tuberculosis (Mtb) in clinical specimens collected from Iranian patients during February 2011-December 2013, by PCR-restriction fragment length polymorphism analysis (PRA) of the hsp65 gene...
September 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28841031/moving-ntm-infections-into-the-21st-century
#7
Neil W Schluger
No abstract text is available yet for this article.
August 25, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28837151/mycobacterium-abscessus-glycopeptidolipids-inhibit-macrophage-apoptosis-and-bacterial-spreading-by-targeting-mitochondrial-cyclophilin-d
#8
Jake Whang, Yong Woo Back, Kang-In Lee, Nagatoshi Fujiwara, Seungwha Paik, Chul Hee Choi, Jeong-Kyu Park, Hwa-Jung Kim
Mycobacterium abscessus (MAB) is a species of nontuberculous mycobacteria (NTM) and a major causative pathogen of pulmonary diseases especially in patients with cystic fibrosis. MAB infection is notoriously difficult to treat because of its intrinsic or inducible resistance to most antibiotics. The rough (R) morphotype of MAB, lacking cell surface glycopeptidolipids (GPLs), is associated with more severe and persistent infection than the smooth (S) type; however, the mechanisms underlying the R type's virulence and the relation with GPLs remain unclear...
August 24, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28836691/disseminated-cutaneous-mycobacterium-kansasii-infection-presenting-with-rosai-dorfman-disease-like-histological-features-in-a-patient-carrying-anti-interferon-%C3%AE-autoantibodies
#9
Yih-An King, Chung-Hong Hu, Yuarn-Jang Lee, Chiou-Feng Lin, Donald Liu, Kuo-Hsien Wang
Typical cutaneous non-tuberculous mycobacteria (NTM) infections show a histopathology pattern of granulomas with admixed Langhans giant cells, and abscesses may be observed in acute lesions. Herein, we describe a patient carrying a high titer of autoantibodies to interferon (IFN)-γ with disseminated Mycobacterium kansasii infection presenting with emperipolesis and Rosai-Dorfman disease (RDD)-like histopathological features characterized by remarkable, large, pale-staining "RD cells", which were CD68 and S100 positive and CD1a negative...
August 24, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28827842/persimmon-derived-tannin-has-bacteriostatic-and-anti-inflammatory-activity-in-a-murine-model-of-mycobacterium-avium-complex-mac-disease
#10
Yoko Matsumura, Masahiro Kitabatake, Noriko Ouji-Sageshima, Satsuki Yasui, Naoko Mochida, Ryuichi Nakano, Kei Kasahara, Koichi Tomoda, Hisakazu Yano, Shin-Ichi Kayano, Toshihiro Ito
Nontuberculous mycobacteria (NTM), including Mycobacterium avium complex (MAC), cause opportunistic chronic pulmonary infections. Notably, MAC susceptibility is regulated by various factors, including the host immune system. Persimmon (Ebenaceae Diospyros kaki Thunb.) tannin is a condensed tannin composed of a polymer of catechin groups. It is well known that condensed tannins have high antioxidant activity and bacteriostatic properties. However, it is hypothesized that condensed tannins might need to be digested and/or fermented into smaller molecules in vivo prior to being absorbed into the body to perform beneficial functions...
2017: PloS One
https://www.readbyqxmd.com/read/28820031/elimination-of-mycobacterium-chimaera-in-a-heater-cooler-device-used-during-on-pump-cardiothoracic-surgery
#11
Conny Nielsen, Conni L Winther, Philip K Thomsen, Jan J Andreasen
Since 2014, several infections with non-tuberculous mycobacteria (NTM) belonging to the species Mycobacterium ( M.) chimaera have been associated with the use of heater-cooler devices during on-pump cardiothoracic surgery both in European countries and the United States of America. Infections have been detected after surgery, with a delay of a few months and up to five years. Bacterial contamination of heater-cooler devices has also been described without any associated infections. In many centres, it has been a challenging task to eliminate NTM from the heater-cooler devices in order to reduce the risk to patients...
September 2017: Perfusion
https://www.readbyqxmd.com/read/28795999/the-utility-of-immunohistochemistry-in-mycobacterial-infection-a-proposal-for-multimodality-testing
#12
Isaac H Solomon, Melanie E Johncilla, Jason L Hornick, Danny A Milner
Mycobacterium species are slow growing bacteria that cause significant morbidity and mortality worldwide. Because of the relative rarity of mycobacterial infections, potential for detection of nonpathogenic environmental contaminants, and substantial costs associated with molecular diagnostics, effective screening methods are needed to identify samples most suitable for molecular testing. While anatomic pathology specimens can be utilized to identify characteristic histologic inflammatory patterns and to directly visualize mycobacteria through histochemical (acid fast bacilli [AFB]) stains, the utility of immunohistochemistry (IHC) in this setting is unknown...
October 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28793869/the-efficacy-safety-and-feasibility-of-inhaled-amikacin-for-the-treatment-of-difficult-to-treat-non-tuberculous-mycobacterial-lung-diseases
#13
Kazuma Yagi, Makoto Ishii, Ho Namkoong, Takahiro Asami, Osamu Iketani, Takanori Asakura, Shoji Suzuki, Hiroaki Sugiura, Yoshitake Yamada, Tomoyasu Nishimura, Hiroshi Fujiwara, Yohei Funatsu, Yoshifumi Uwamino, Tetsuro Kamo, Sadatomo Tasaka, Tomoko Betsuyaku, Naoki Hasegawa
BACKGROUND: In multidrug regimens, including an intravenous aminoglycoside (e.g. amikacin [AMK]) is recommended for difficult-to-treat non-tuberculous mycobacterial (NTM) lung diseases. We aimed to evaluate the efficacy, safety, and feasibility of inhaled AMK therapy in patients with difficult-to-treat NTM lung diseases in a retrospective chart review. METHODS: The study population consisted of patients with NTM lung diseases who received combination therapy, including inhaled AMK therapy, at Keio University Hospital (Tokyo, Japan), from January 2014 through May 2016...
August 9, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28777004/whole-exome-sequencing-identify-the-6q12-q16-linkage-region-and-a-candidate-gene-ttk-for-pulmonary-nontuberculous-mycobacterial-disease
#14
Fei Chen, Eva P Szymanski, Kenneth N Olivier, Xinyue Liu, Hervé Tettelin, Steven M Holland, Priya Duggal
RATIONALE: Pulmonary nontuberculous mycobacterial (PNTM) disease often affects white postmenopausal women, with a tall and lean body habitus and higher rates of scoliosis, pectus excavatum, mitral valve prolapse, and mutations in the CFTR gene. These clinical features and the familial clustering of the disease suggest an underlying genetic mechanism. OBJECTIVES: To map the genes associated with PNTM, whole-exome sequencing (WES) was conducted in 12 PNTM families and 57 sporadic cases recruited at the NIH Clinical Center during 2001-2013...
August 4, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28776533/efficacy-of-calcium-hypochlorite-and-ultraviolet-irradiation-against-mycobacterium-fortuitum-and-mycobacterium-marinum
#15
E A Roshani Edirisinghe, D R Anuruddhika Dissanayake, Charmalie L Abayasekera, Appudurai Arulkanthan
BACKGROUND: Nontuberculous mycobacteria (NTM) cause opportunistic infections with increasing frequency in immunocompromised humans. Water is one of the natural sources for transmission of NTM and plays a major role in the epidemiology of NTM infections. This study evaluated the efficacy of calcium hypochlorite and ultraviolet irradiation (UV) to eliminate potentially zoonotic NTM species such as M. marinum and M. fortuitum. MATERIALS AND METHODS: Bacterial suspensions containing1-4 × 105 CFU/ml were exposed to 5, 50, 100, 1,000 and 10,000 mg/L of Ca (OCl)2for 1, 5, 10, 15, 20, 30 and 60 minutes, and 6,000 μW/cm2 UV dose for 5, 10, 20, 30, 60 and 120 seconds...
July 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28776521/epidemiological-and-laboratorial-profile-of-patients-with-isolation-of-nontuberculous-mycobacteria
#16
Heloisa Silveira Paro Pedro, Andréa Gobetti Vieira Coelho, Isabela Mazuco Mansur, Ana Carolina Chiou, Maria Izabel Ferreira Pereira, Naiara Cristina Ule Belotti, Manuela Galloy Sanches Ismael, Maria Rita de Cássia Oliveira Cury, Susilene Maria Tonelli Nardi, Érica Chimara
BACKGROUND: An increase in NTM diseases in the international scenario has been observed in recent years. AIMS: To analyze the epidemiological and laboratory profiles of patients with isolation of nontuberculous mycobacteria (NTM) over one decade. A retrospective analysis of records of a mycobacterial reference laboratory found 135 cases with isolation of NTM. METHODS: Clinical and epidemiological data were collected from the records of government health clinics and from the State notification system (TBWEB)...
July 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28771154/multiresistant-opportunistic-pathogenic-bacteria-isolated-from-polluted-rivers-and-first-detection-of-nontuberculous-mycobacteria-in-the-algerian-aquatic-environment
#17
Lydia Neïla Djouadi, Okba Selama, Ahmed Abderrahmani, Amel Bouanane-Darenfed, Lamia Abdellaziz, Meriam Amziane, Marie-Laure Fardeau, Farida Nateche
Opportunistic infections constitute a major challenge for modern medicine mainly because the involved bacteria are usually multiresistant to antibiotics. Most of these bacteria possess remarkable ability to adapt to various ecosystems, including those exposed to anthropogenic activities. This study isolated and identified 21 multiresistant opportunistic bacteria from two polluted rivers, located in Algiers. Cadmium, lead, and copper concentrations were determined for both water samples to evaluate heavy metal pollution...
August 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/28756811/comparing-the-genotype-and-drug-susceptibilities-between-mycobacterium-avium-and-mycobacterium-intracellulare-in-china
#18
Hui Wen Zheng, Yu Pang, Guang Xue He, Yuan Yuan Song, Yan Lin Zhao
OBJECTIVE: Mycobacterium avium (M. avium) and Mycobacterium intracellulare (M. intracellulare) are the major causative agents of nontuberculous mycobacteria (NTM)-related pulmonary infections. However, little is known about the differences in drug susceptibility profiles between these two species. METHODS: A total of 393 NTM isolates were collected from Shanghai Pulmonary Disease Hospital. Sequencing of partial genes was performed to identify the strains at species level...
July 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28754702/mycobacterium-abscessus-displays-fitness-for-fomite-transmission
#19
Kenneth C Malcolm, Silvia M Caceres, Jennifer R Honda, Rebecca M Davidson, L Elaine Epperson, Michael Strong, Edward D Chan, Jerry A Nick
Mycobacterium abscessus (Mab) is a rapidly growing nontuberculous mycobacterium (NTM) increasingly reported in soft tissue infections and chronic lung diseases, including cystic fibrosis. The environmental source of Mab has not been definitively identified, but NTM have been detected in soil and water. To determine the potential of soil-derived Mab as an infectious source we explored the association, growth, and survival of Mab with defined mineral particulates, including kaolin, halloysite, and silicone dioxide, and house dust as possible Mab fomites...
July 28, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28749330/in-vitro-activity-of-bedaquiline-against-rapidly-growing-nontuberculous-mycobacteria
#20
Diana A Aguilar-Ayala, Margo Cnockaert, Emmanuel André, Koen Andries, Jorge A Gonzalez-Y-Merchand, Peter Vandamme, Juan Carlos Palomino, Anandi Martin
Bedaquiline (BDQ) has been proven to be effective in the treatment of multidrug-resistant tuberculosis. We hypothesized that BDQ could be a potential agent to treat nontuberculous mycobacterial (NTM) infection. The objective of this study was to evaluate the in vitro activity of BDQ against rapidly growing mycobacteria by assessing the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) against 18 NTM strains. For MIC determination we performed the resazurin microtitre assay broth dilution, and for the MBC the c...
August 2017: Journal of Medical Microbiology
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