keyword
MENU ▼
Read by QxMD icon Read
search

haemolysis

keyword
https://www.readbyqxmd.com/read/27902286/macrococcus-canis-sp-nov-a-skin-bacterium-associated-with-infections-in-dogs
#1
Stefanie Gobeli Brawand, Kerstin Cotting, Elena Gómez-Sanz, Alexandra Collaud, Andreas Thomann, Isabelle Brodard, Sabrina Rodriguez Campos, Christian Strauss, Vincent Perreten
Gram-stain positive cocci were isolated from miscellaneous sites of the skin of healthy dogs as well as from infection sites in dogs. The closest relative by sequencing of the 16S rRNA was Macrococcus caseolyticus with 99.7% sequence identity, but compared to M. caseolyticus, the novel strains shared only 90.8% to 93.5% DNA identity to cpn60, dnaJ, rpoB, and sodA partial genes, respectively. The two species also exhibited other phenotypic characteristics and the majority displayed a visible haemolysis on sheep blood agar, while M...
November 16, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27900772/hematopoietic-stem-cell-transplantation-for-people-with-%C3%A3-thalassaemia-major
#2
REVIEW
Vanitha A Jagannath, Zbys Fedorowicz, Amani Al Hajeri, Akshay Sharma
BACKGROUND: Thalassemia is an inherited autosomal recessive blood disorder, caused by mutations in globin genes or their regulatory regions. This results in a reduced rate of synthesis of one of the globin chains that make up haemoglobin. In ß-thalassaemia major there is an underproduction of ß-globin chains combined with excess of free α-globin chains. The excess free α-globin chains precipitate in red blood cells, leading to their destruction (haemolysis) and ineffective erythropoiesis...
November 30, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27893349/platelet-leucocyte-and-red-cell-derived-microparticles-in-stored-whole-blood-with-and-without-leucofiltration-with-and-without-ionising-radiation
#3
Shunnichi Saito, Kenneth E Nollet, Alain M Ngoma, Takako Ono, Hitoshi Ohto
BACKGROUND: Storage lesion, including microparticle formation, has been partially characterised in whole blood, but not in all combinations of pre-storage leucofiltration and/or irradiation. MATERIALS AND METHODS: Single-donor whole blood products were processed into four subunits: with and without leucofiltration, with and without X-irradiation (25 Gy). Platelet-, leucocyte-, and erythrocyte-derived microparticles and free haemoglobin were measured periodically throughout 42 days of storage...
November 7, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27889303/pgla-h-tandem-repeat-peptides-active-against-multidrug-resistant-clinical-bacterial-isolates
#4
Tomislav Rončević, Goran Gajski, Nada Ilić, Ivana Goić-Barišić, Marija Tonkić, Larisa Zoranić, Juraj Simunić, Monica Benincasa, Marijana Mijaković, Alessandro Tossi, Davor Juretić
Antimicrobial peptides (AMPs) are promising candidates for new antibiotic classes but often display an unacceptably high toxicity towards human cells. A naturally produced C-terminal fragment of PGLa, named PGLa-H, has been reported to have a very low haemolytic activity while maintaining a moderate antibacterial activity. A sequential tandem repeat of this fragment, diPGLa-H, was designed, as well as an analogue with a Val to Gly substitution at a key position. These peptides showed markedly improved in vitro bacteriostatic and bactericidal activity against both reference strains and multidrug resistant clinical isolates of Gram-negative and Gram-positive pathogens, with generally low toxicity for human cells as assessed by haemolysis, cell viability, and DNA damage assays...
November 23, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27888224/massive-haemolysis-gas-forming-liver-abscess-and-sepsis-due-to-clostridium-perfringens-bacteraemia
#5
Rafael García Carretero, Marta Romero Brugera, Oscar Vazquez-Gomez, Noelia Rebollo-Aparicio
Clostridial soft tissue infections are infrequent, but can be life-threatening when associated with certain underlying conditions, such as immunosuppression or malignancy. When bacteraemia occurs, it can be accompanied by haemolysis. Only surgical removal of the focus of infection and early onset of antibiotic therapy can prevent a very poor outcome. We describe the case of a man aged 65 years who presented with sepsis, haemolysis and rapid worsening. The identification of a gas-forming liver abscess, the early percutaneous drainage and the prompt initiation of antibiotic treatment were the key factors in the outcome of this patient...
November 25, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27885843/current-evaluation-and-management-of-anaemia-in-patients-with-inflammatory-bowel-disease
#6
Julia Martin, Heinfried H Radeke, Axel Dignass, Jürgen Stein
Anaemia is a common extraintestinal manifestation in IBD patients and considerably impacts disease prognosis, hospitalisation rates and time lost from work. While iron deficiency anaemia is predominant, combinations of haematimetric and biochemical markers enable detection and targeted therapy of other aetiologies including vitamin B12/folic acid deficiencies, haemolysis, myelosuppression and pharmacotherapies. Areas covered: Current literature was searched for articles focusing on aetiology, diagnostics and therapy of anaemia in IBD...
November 25, 2016: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27884438/toxoplasma-gondii-in-stranded-marine-mammals-from-the-north-sea-and-eastern-atlantic-ocean-findings-and-diagnostic-difficulties
#7
Norbert van de Velde, Brecht Devleesschauwer, Mardik Leopold, Lineke Begeman, Lonneke IJsseldijk, Sjoukje Hiemstra, Jooske IJzer, Andrew Brownlow, Nicholas Davison, Jan Haelters, Thierry Jauniaux, Ursula Siebert, Pierre Dorny, Stéphane De Craeye
The occurrence of the zoonotic protozoan parasite Toxoplasma gondii in marine mammals remains a poorly understood phenomenon. In this study, samples from 589 marine mammal species and 34 European otters (Lutra lutra), stranded on the coasts of Scotland, Belgium, France, The Netherlands and Germany, were tested for the presence of T. gondii. Brain samples were analysed by polymerase chain reaction (PCR) for detection of parasite DNA. Blood and muscle fluid samples were tested for specific antibodies using a modified agglutination test (MAT), a commercial multi-species enzyme-linked immunosorbent assay (ELISA) and an immunofluorescence assay (IFA)...
October 30, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27864978/reduction-of-biological-response-modifiers-in-the-supernatant-of-washed-paediatric-red-blood-cells
#8
Y S Loh, S Tan, M Kwok, M J Stark, D C Marks
BACKGROUND: Washing of red blood cells (RBC) can reduce unwanted biological response modifiers (BRMs) that can mediate transfusion complications in infants. The aim of this study was to examine the in vitro quality and the changes in BRMs following washing in paediatric RBC units. MATERIALS AND METHODS: A pool and split design was used to prepare RBC (either 1 or 4 days old; n = 26 pairs). One unit was washed with 0·9% saline by centrifugation and then resuspended in SAG-M, while the other remained unwashed...
November 2016: Vox Sanguinis
https://www.readbyqxmd.com/read/27855617/eryptosis-ally-or-enemy
#9
Marilena Briglia, Maria Antonia Rossi, Caterina Faggio
Prior to senescence, erythrocytes may, experience injury which compromises their integrity and thus triggers suicidal erythrocyte death or eryptosis. This mechanism is characterised by cell shrinkage, cell membrane blebbing, and cell membrane phospholipid scrambling after phosphatidylserine exposure on the cell surface that is identified by macrophages which engulf and degrade the eryptotic cells. The term eryptosis also includes typical mechanisms, which contribute to the triggering of this process. Among them: oxidative stress, Ca2+ entry with an increase in cytosolic Ca2+ activity ([Ca ]i) and the activation of p38 kinase, which is a kinase expressed in human erythrocytes and activated after hyperosmotic shock...
November 18, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27830112/mycoplasma-pneumonia-with-persistent-lymphadenopathy-and-severe-cold-agglutinin-haemolysis
#10
Mit Shah, Sajid Khan, Kenneth Chan
Mycoplasma pneumonia is an atypical pneumonia commonly affecting young patients with generally mild clinical course. We present a case of a 66-year-old female presenting with weight loss, night sweats and low-grade pyrexia. She acquired symptomatic haemolytic anaemia requiring blood transfusion, markedly raised erythrocyte sedimentation rate (ESR) to 114 mm/hr and extensive peri-hilar lymphadenopathy on computed tomography (CT) scan. After excluding malignancy and granulomatous diseases, she made good recovery although a 4 week follow-up CT scan showed persistent but resolving lymphadenopathy...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27829883/hepatic-capsular-rupture-in-pregnancy
#11
Charlotte J Frise, Peyton Davis, Graham Barker, Douglas Wilkinson, Lucy Mackillop
The syndrome of haemolysis, elevated liver enzymes and low platelets is a rare condition specific to pregnancy, affecting approximately 5-20% of all pre-eclamptic pregnancies. Described here is a woman in her first pregnancy, who experienced an intrauterine death following a significant hepatic haematoma and capsular rupture, in the absence of classical clinical features suggestive of pre-eclampsia. The events that followed suggested haemolysis, elevated liver enzymes and low platelets syndrome as the likely diagnosis...
December 2016: Obstetric Medicine
https://www.readbyqxmd.com/read/27818359/delayed-haemolysis-secondary-to-treatment-of-severe-malaria-with-intravenous-artesunate-report-on-the-experience-of-a-referral-centre-for-tropical-infections-in-spain
#12
Teresa Aldámiz-Echevarría Lois, Ana López-Polín, Francesca F Norman, Begoña Monge-Maillo, Rogelio López-Vélez, Jose Antonio Pérez-Molina
BACKGROUND: Post-artesunate delayed haemolysis is described as hemolytic anemia presenting days after malaria treatment in hyperparasitemic patients. Physiopathological mechanisms and clinical manifestations have not been thoroughly characterised. METHODS: We conducted a retrospective study of hospitalised malaria patients who received artemisinin derivatives from January 1, 2010 to December 31, 2015. RESULTS: 21 patients were included in the study: 11 travellers, 8 travellers visiting friends and relatives and 2 immigrants...
November 3, 2016: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/27815202/haemolytic-and-antibiofilm-properties-of-haemocyanin-purified-from-the-haemolymph-of-indian-white-shrimp-fenneropenaeus-indicus
#13
Ramachandran Ishwarya, Baskaralingam Vaseeharan, Arokiadhas Iswarya, Sivashanmugam Karthikeyan
Haemocyanin (Hc) is an important non-specific immune macromolecule present in the haemolymph of both mollusks and crustaceans. In the present study, Hc was purified from the haemolymph of Indian white shrimp Fenneropenaeus indicus by gel filtration chromatography and it exhibits a single band with a molecular weight of 74 kDa on SDS-PAGE. The X-ray diffraction (XRD) and High performance liquid chromatography (HPLC) result of purified Hc express single peak at 31.5° be a sign of crystalline nature and appear as a single peak with a retention time of 5...
December 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27810201/oxidative-stress-and-dna-damage-in-horses-naturally-infected-with-theileria-equi
#14
M Radakovic, D Davitkov, S Borozan, S Stojanovic, J Stevanovic, V Krstic, Z Stanimirovic
The aim of this study was to determine the concentrations of oxidative stress parameters and DNA damage in horses infected by Theileria equi. Initial screening of 110 horses with duplex PCR enabled the selection of 30 infected horses with T. equi and 30 free of infection (control). Specimens from the 60 horses were further analysed by determining the following oxidative stress parameters: extent of haemolysis (EH), plasma free haemoglobin (PHb), catalase (CAT), Cu,Zn superoxide dismutase (SOD1), paraoxonase (PON1), nitrite (NO2(-)), total nitrate and nitrite (NOx), malondialdehyde (MDA) and free thiol groups (-SH)...
November 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27796108/a-study-on-the-prevalence-of-dog-erythrocyte-antigen-1-1-and-detection-of-canine-babesia-by-polymerase-chain-reaction-from-apparently-healthy-dogs-in-a-selected-rural-community-in-zimbabwe
#15
Solomon Dhliwayo, Tariro A Makonese, Belinda Whittall, Silvester M Chikerema, Davies M Pfukenyi, Musavenga T Tivapasi
A study was carried out to determine the prevalence of blood group antigen dog erythrocyte antigen (DEA) 1.1 in mixed breed dogs in rural Chinamhora, Zimbabwe. DEA 1.1 is clinically the most important canine blood group as it is the most antigenic blood type; hence, DEA 1.1 antibodies are capable of causing acute haemolytic, potentially life-threatening transfusion reactions. In this study, blood samples were collected from 100 dogs in Chinamhora, and blood typing was carried out using standardised DEA 1.1 typing strips with monoclonal anti-DEA 1...
October 26, 2016: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/27796106/reference-intervals-for-selected-serum-biochemistry-analytes-in-cheetahs-i-acinonyx-jubatus-i
#16
Gavin C Hudson-Lamb, Johan P Schoeman, Emma H Hooijberg, Sonja K Heinrich, Adrian S W Tordiffe
Published haematologic and serum biochemistry reference intervals are very scarce for captive cheetahs and even more for free-ranging cheetahs. The current study was performed to establish reference intervals for selected serum biochemistry analytes in cheetahs. Baseline serum biochemistry analytes were analysed from 66 healthy Namibian cheetahs. Samples were collected from 30 captive cheetahs at the AfriCat Foundation and 36 free-ranging cheetahs from central Namibia. The effects of captivity-status, age, sex and haemolysis score on the tested serum analytes were investigated...
February 26, 2016: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/27773175/analysis-of-haemolysis-rates-when-comparing-blood-from-intravenous-catheter-vs-venepuncture-in-the-emergency-department-setting
#17
Martin J Churcher, Chris Florkowski, Sarah Carr, Lesney Stuart, Peter M George
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27766364/applicability-of-predictive-toxicology-methods-for-monoclonal-antibody-therapeutics-status-quo-and-scope
#18
Arathi Kizhedath, Simon Wilkinson, Jarka Glassey
Biopharmaceuticals, monoclonal antibody (mAb)-based therapeutics in particular, have positively impacted millions of lives. MAbs and related therapeutics are highly desirable from a biopharmaceutical perspective as they are highly target specific and well tolerated within the human system. Nevertheless, several mAbs have been discontinued or withdrawn based either on their inability to demonstrate efficacy and/or due to adverse effects. Approved monoclonal antibodies and derived therapeutics have been associated with adverse effects such as immunogenicity, cytokine release syndrome, progressive multifocal leukoencephalopathy, intravascular haemolysis, cardiac arrhythmias, abnormal liver function, gastrointestinal perforation, bronchospasm, intraocular inflammation, urticaria, nephritis, neuropathy, birth defects, fever and cough to name a few...
October 20, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27746589/addition-of-sodium-pyruvate-to-stored-red-blood-cells-attenuates-liver-injury-in-a-murine-transfusion-model
#19
Sha Xia, Gan Chen, Bo Wang, Yujing Yin, Zhenwei Sun, Jingxiang Zhao, Penglong Li, Lian Zhao, Hong Zhou
RBCs undergo numerous changes during storage and stored RBCs may induce adverse effects, ultimately resulting in organ injury in transfusion recipients. We tested the hypothesis that the addition of SP to stored RBCs would improve the quality of the stored RBCs and mitigate liver injury after transfusion in a murine model. RBCs were harvested from C57BL/6J mice and stored for 14 days in CPDA-1 containing either a solution of SP in saline or saline alone. Haemolysis, the 24-hour posttransfusion recovery, the oxygen-carrying capacity, and the SOD activity of stored RBCs were evaluated...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27730689/measurement-of-haemolysis-markers-following-transfusion-of-uncrossmatched-low-titer-group-o-whole-blood-in-civilian-trauma-patients-initial-experience-at-a-level-1-trauma-centre
#20
J N Seheult, D J Triulzi, L H Alarcon, J L Sperry, A Murdock, M H Yazer
BACKGROUND/OBJECTIVES: The safety of administering uncrossmatched, group O, cold-stored, whole blood (cWB) during civilian trauma resuscitation was evaluated. METHODS/MATERIALS: Male trauma patients with haemorrhage-induced hypotension who received leuko-reduced uncrossmatched group O+, low titer (<50) anti-A and -B, platelet-replete cWB during initial resuscitation were included. The biochemical markers of haemolysis (lactate dehydrogenase, total bilirubin, haptoglobin, creatinine, serum potassium) were measured on the day of cWB receipt (day 0), and over the next 2 days, reports of transfusion reactions and total blood product administration in first 24 h of admission were recorded...
October 12, 2016: Transfusion Medicine
keyword
keyword
119365
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"