keyword
MENU ▼
Read by QxMD icon Read
search

haemolysis

keyword
https://www.readbyqxmd.com/read/29779226/phenotypic-characterization-of-enzymatic-activity-of-clinical-dermatophyte-isolates-from-animals-with-and-without-skin-lesions-and-humans
#1
Sebastian Gnat, Dominik Łagowski, Aneta Nowakiewicz, Przemysław Zięba
AIMS: The pathogenesis of dermatophytoses is associated with the secretion of enzymes degrading the infected tissue components. Although many studies on enzymatic activity of dermatophytes have been conducted over the years, there have been no concrete proposals on construction of the profile of enzymes characteristic of individual species, genus, or ecological types of dermatophytes. The aim of this study was to assess the capability of clinical dermatophyte isolates from both symptomatic and asymptomatic animals and humans to produce different enzymes...
May 20, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29778768/prevalence-of-g6pd-deficiency-and-associated-haematological-parameters-in-children-from-botswana
#2
Thato Motshoge, Grace Ababio, Larysa Aleksenko, Sajini Souda, Charles Waithaka Muthoga, Naledi Mutukwa, Leabaneng Tawe, Pleasure Ramatlho, Lesego Gabaitiri, Simon Chihanga, Tjantilili Mosweunyane, Shimeles Hamda, Kentse Moakofhi, Davies Ntebela, Elias Peloewetse, Loeto Mazhani, Jeffrey M Pernica, John Read, Isaac K Quaye, Giacomo Maria Paganotti
Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is commonly seen in malaria endemic areas as it is known to confer a selective advantage against malaria. Recently, we reported a high proportion of asymptomatic reservoir of Plasmodium vivax in Botswana, that calls for intervention with primaquine to achieve radical cure of vivax malaria. Considering that individuals with this enzyme deficiency are at risk of haemolysis following primaquine treatment, assessment of the population for the relative frequency of G6PD deficiency is imperative...
May 17, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29774554/laboratory-assessment-of-the-quality-of-adult-and-neonatal-red-cell-concentrates-manufactured-from-whole-blood-exchange-transfusion-or-intrauterine-transfusion-red-cell-units
#3
A Meli, H New, M McAndrew, M Wiltshire, R Cardigan
BACKGROUND: We evaluated the quality of red cell components in additive solution over 42 days of storage when re-manufactured from neonatal exchange transfusion (ExTx) or intrauterine transfusion (IUT) units on day 7 for issue to adults, neonates or infants. MATERIALS AND METHODS: Red cell concentrates (RCC) manufactured from WB were compared to RCC re-manufactured from ExTx or IUT on day 7, and red cell splits (RCS) manufactured from WB were compared to RCS re-manufactured from ExTx or IUT on day 7...
May 17, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29768228/facile-synthesis-by-a-covalent-binding-reaction-for-ph-responsive-drug-release-of-carboxylated-chitosan-coated-hollow-mesoporous-silica-nanoparticles
#4
Qiang Liu, Jiao Wang, Linnan Yang, Xiaofei Xia, Mei Wang, Shengguang Chen, Rongrong Zhu, Qingxiu Wang, Xianzheng Wu, Shilong Wang
In this study, a promising drug nano-carrier system consisting of mono-dispersed and pH sensitive carboxylated chitosan-hollow mesoporous silica nanoparticles (Ccs-HMSNs) suitable for the treatment of malignant cells was synthesised and investigated. At neutral pH, the Ccs molecules are orderly aggregated state, which could effectively hinder the release of loaded drug molecules. However, in slightly acidic environment, Ccs chains are heavily and flexibly entangled in gel state, which would enhance the subsequent controlled release of the loaded drug...
June 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29757133/haemolysis-index-for-the-screening-of-intravascular-haemolysis-a-novel-diagnostic-opportunity
#5
REVIEW
Giuseppe Lippi, Emmanuel J Favaloro, Massimo Franchini
The diagnostic approach to patients with intravascular haemolysis remains challenging, since no first-line laboratory test seems to be entirely suitable for the screening of this condition. Recent evidence shows that an enhanced cell-free haemoglobin (fHb) concentration in serum or plasma is a reliable marker of red blood cell injury, and may also predict clinical outcomes in patients with different forms of haemolytic anaemias. However, the routine use of the haemiglobincyanide assay, the current reference method for measuring fHb, seems unsuitable for a timely diagnosis of intravascular haemolysis, for many safety and practical reasons...
May 8, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29753681/quality-of-plasma-samples-and-bd-vacutainer-barricor-tubes-effects-of-centrifugation
#6
Andrea Padoan, Martina Zaninotto, Elisa Piva, Laura Sciacovelli, Ada Aita, Adriano Tasinato, Mario Plebani
BACKGROUNDS: The BD Vacutainer ® Barricor™ Plasma collection tube (BD Barricors) uses an innovative non-gel separation method. This study compared the plasma residual cell count (PRCC) obtained from BD Barricor and from BD PST II plasma tubes. METHODS: Four BD Barricors and one BD PST II were collected from 40 donors. BD PST II was centrifuged at 1300g/10 min, while the BD Barricors were centrifuged at 1800g/10 min, 4000g/3 min, 4000g/7 min and 4000g/15 min...
May 10, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29734776/an-ointment-consisting-of-the-phage-lysin-lysgh15-and-apigenin-for-decolonization-of-methicillin-resistant-staphylococcus-aureus-from-skin-wounds
#7
Mengjun Cheng, Lei Zhang, Hao Zhang, Xinwei Li, Yanmei Wang, Feifei Xia, Bin Wang, Ruopeng Cai, Zhimin Guo, Yufeng Zhang, Yalu Ji, Changjiang Sun, Xin Feng, Liancheng Lei, Yongjun Yang, Wenyu Han, Jingmin Gu
Staphylococcus aureus ( S. aureus ) is a common and dangerous pathogen that causes various infectious diseases. Skin damage, such as burn wounds, are at high risk of Staphylococcus aureus colonization and infection, which increases morbidity and mortality. The phage lysin LysGH15 exhibits highly efficient lytic activity against methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) strains. Apigenin (api) significantly decreases haemolysis of rabbit erythrocytes caused by S. aureus and shows anti-inflammatory function...
May 6, 2018: Viruses
https://www.readbyqxmd.com/read/29732532/pathogenesis-diagnosis-and-treatment-of-anaemia-in-immune-mediated-gastrointestinal-disorders
#8
REVIEW
Gaetano Bergamaschi, Antonio Di Sabatino, Gino R Corazza
Immune-mediated disorders affecting the gastrointestinal (GI) tract may compromise GI integrity, interfere with the absorption of nutrients and cause bleeding and inflammation. All these features contribute to the pathogenesis of anaemia, the most prevalent extra-intestinal manifestation of immune-mediated GI disorders. Anaemia is most commonly due to iron deficiency and/or inflammation, but vitamin deficiencies and, more infrequently, autoimmune haemolysis or drug-induced myelosuppression can be involved. Here we address several issues related to the differential diagnosis and treatment of anaemia in immune-mediated GI disorders, giving particular relevance to the problem of iron deficiency anaemia associated with inflammation...
May 6, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29729627/electropolymerized-hydrophilic-coating-on-stainless-steel-for-biomedical-applications
#9
Paulina A Trzaskowska, Aleksandra Kuźmińska, Beata Butruk-Raszeja, Ewa Rybak, Tomasz Ciach
Current metal implants (e.g. stents) covered with drug-eluting coatings are not robust for long-term usage. Other types and methods of coatings are needed, especially ones that are not prone to activity loss in vivo. In this paper, the method of stainless steel (SS) coating with poly(ethylene glycol) dimethacrylate (PEGDMA) with the use of electropolymerization (EP) is presented. The application of a specific and simple reaction mixture enabled the production of SS-PEGDMA materials that possessed a homogenous surface...
April 27, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29709686/dual-functions-of-a-4-hydroxyphenylpyruvate-dioxygenase-for-vibrio-splendidus-survival-and-infection
#10
Weikang Liang, Weiwei Zhang, Yina Shao, Xuelin Zhao, Chenghua Li
Vibrio splendidus is a well-documented pathogenic bacterium that can trigger different diseases, including skin ulcer syndrome in Apostichopus japonicus. In our previous study, a gene named Vshppd encoding a 4-hydroxyphenylpyruvate dioxygenase homologue was cloned from pathogenic V. splendidus, and validated to be responsible for the haemolysis activities of V. splendidus. In this study, Vshppd was determined to participate in the catabolism of tyrosine and promote pyomelanin production in Escherichia coli BL21 (DE3) harboring Vshppd...
April 27, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29701388/trifecta-bioprothesis-for-aortic-valve-replacement-our-experience
#11
João Pedro Monteiro, Diogo Rijo, Sara Simões Costa, Rodolfo Pereira, Ricardo Ferraz, Miguel Guerra
INTRODUCTION: Bioprosthesis are increasingly used for aortic valve replacement (AVR), as a result of increasing elderly patients, as well as, continuous improvements in durability and hemodynamic performance of pericardial prosthesis. The Trifecta aortic prosthesis is a latest-generation trileaflet stented pericardial valve designed for supra-annular placement in the aortic position. This study establishes the safety and early clinical and hemodynamic performance of the Trifecta valve...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29699565/in-vitro-quality-control-analysis-after-processing-and-during-storage-of-feline-packed-red-blood-cells-units
#12
C Blasi Brugué, Rui R F Ferreira, I Mesa Sanchez, Rita M C Graça, Inês M Cardoso, Augusto J F de Matos, Rafael Ruiz de Gopegui
BACKGROUND: During the storage of packed red blood cells (pRBC), packed cell volume (PCV), bacterial contamination and percentage of haemolysis [percentage of free haemoglobin (HGB) in relation to the total HGB] are important quality parameters. Both PCV and haemolysis are indicators of the cellular integrity of stored units. There are no published experimental studies that evaluated these parameters during storage of feline pRBC using SAGM (adenine, dextrose, mannitol and sodium chloride) as the additive solution...
April 27, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29698750/low-serum-kallistatin-level-was-associated-with-poor-neurological-outcome-of-out-of-hospital-cardiac-arrest-survivors-proteomics-study
#13
Yoon Sun Jung, Woon Yong Kwon, Gil Joon Suh, Sungyoon Moon, Mi-Hee Han, Je-In Youn, Sang-Uk Seo, Kyung Su Kim, Seung-Yong Seong
AIM OF THE STUDY: To identify proteins of which depletion are associated with the poor 6-month neurological outcome of out-of-hospital cardiac arrest survivors. METHODS: Seven healthy volunteers and 34 out-of-hospital cardiac arrest survivors admitted to the intensive care unit (ICU) and underwent targeted-temperature management were enrolled. According to the 6-month cerebral performance category (CPC) scale, patients were divided into the good (CPC 1 - 2) and poor (CPC 3 - 5) outcome groups...
April 23, 2018: Resuscitation
https://www.readbyqxmd.com/read/29696091/curcumin-loaded-graphene-oxide-flakes-as-an-effective-antibacterial-system-against-methicillin-resistant-staphylococcus-aureus
#14
F Bugli, M Cacaci, V Palmieri, R Di Santo, R Torelli, G Ciasca, M Di Vito, A Vitali, C Conti, M Sanguinetti, M De Spirito, M Papi
Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for serious hospital infections worldwide and represents a global public health problem. Curcumin, the major constituent of turmeric, is effective against MRSA but only at cytotoxic concentrations or in combination with antibiotics. The major issue in curcumin-based therapies is the poor solubility of this hydrophobic compound and the cytotoxicity at high doses. In this paper, we describe the efficacy of a composite nanoparticle made of curcumin (CU) and graphene oxide (GO), hereafter GOCU, in MRSA infection treatment...
June 6, 2018: Interface Focus
https://www.readbyqxmd.com/read/29691249/hypertensive-pregnancy-complications-in-women-with-epilepsy-and-antiepileptic-drugs-a-population-based-cohort-study-of-first-pregnancies-in-norway
#15
Kim Christian Danielsson, Ingrid Borthen, Nils-Halvdan Morken, Nils Erik Gilhus
OBJECTIVES: To estimate the risk of hypertensive pregnancy complications in women with epilepsy, with and without antiepileptic drugs, and assess the risk associated with the four most common antiepileptic drugs. DESIGN: A population-based cohort study using linked data from the Medical Birth Registry of Norway and the Norwegian Prescription Database. Women with epilepsy with and without antiepileptic drugs were compared with women without epilepsy. SETTING: Norway, 2004-2012...
April 24, 2018: BMJ Open
https://www.readbyqxmd.com/read/29690924/the-effect-of-regularly-dosed-paracetamol-versus-no-paracetamol-on-renal-function-in-plasmodium-knowlesi-malaria-packnow-study-protocol-for-a-randomised-controlled-trial
#16
Daniel J Cooper, Katherine Plewes, Matthew J Grigg, Giri S Rajahram, Kim A Piera, Timothy William, Mark D Chatfield, Tsin Wen Yeo, Arjen M Dondorp, Nicholas M Anstey, Bridget E Barber
BACKGROUND: Plasmodium knowlesi is the most common cause of human malaria in Malaysia. Acute kidney injury (AKI) is a frequent complication. AKI of any cause can have long-term consequences, including increased risk of chronic kidney disease, adverse cardiovascular events and increased mortality. Additional management strategies are therefore needed to reduce the frequency and severity of AKI in malaria. In falciparum malaria, cell-free haemoglobin (CFHb)-mediated oxidative damage contributes to AKI...
April 24, 2018: Trials
https://www.readbyqxmd.com/read/29678738/autochthonous-lactic-acid-bacteria-isolated-from-pig-faeces-in-thailand-show-probiotic-properties-and-antibacterial-activity-against-enteric-pathogenic-bacteria
#17
Wandee Sirichokchatchawan, Puwiya Pupa, Prasert Praechansri, Nutthee Am-In, Somboon Tanasupawat, Piengchan Sonthayanon, Nuvee Prapasarakul
Lactic acid bacteria (LAB) play an important role in pig health and performance that arises from their beneficial impacts on the balance of gastrointestinal microbes, ability to fight enteric pathogens, and capacity to support the immune system. The aim of this study was to evaluate the functional and safety aspects of five previously isolated autochthonous LAB strains, (Lactobacillus plantarum 22F, 25F and 31F, Pediococcus acidilactici 72N and Pediococcus pentosaceus 77F) from pig faeces as potential probiotics for a pig feed supplement...
April 17, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29678464/biofilm-inhibition-and-anti-candida-activity-of-a-cationic-lipo-benzamide-molecule-with-twin-nonyl-chain
#18
Tushar Jain, Prathap Reddy Muktapuram, Komal Sharma, Owk Ravi, Garima Pant, Kalyan Mitra, Surendar Reddy Bathula, Dibyendu Banerjee
A series of cationic lipo-benzamide compounds with varying lengths of hydrocarbon chains (C2M-C18M) were evaluated for anti-Candida activity. Four compounds harbouring 8-11 hydrocarbon chains demonstrated concentration-dependent inhibition of fungal cell growth with Minimum Inhibitory Concentration (MIC) of ≤6.2 µg ml-1 . The most active compound (C9M) inhibited growth of both Candida albicans and non-albicans strains and is equally active against pairs of azole sensitive and resistant clinical isolates of C...
April 12, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29677388/engulfment-of-hb-activated-platelets-differentiates-monocytes-into-pro-inflammatory-macrophages-in-pnh-patients
#19
Rashi Singhal, Sheetal Chawla, Harish Batra, Sameer Gupta, Amrita Ojha, Deepak K Rathore, Tulika Seth, Prasenjit Guchhait
The distinct response shown by different phenotypes of macrophages and monocytes under various clinical conditions have put the heterogeneity of these cells into focus of investigation for several diseases. Recently we have described that after engulfing Hb-activated platelets, classical monocytes differentiated into pro-inflammatory phenotypes, which were abundant in the circulation of PNH and SCD patients. Our current study shows that upon engulfment of Hb-activated platelets, monocytes differentiate into M1-macrophages under M1-polarization stimulus (GM-CSF, IFN-γ+LPS)...
April 20, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29677199/implications-of-current-therapeutic-restrictions-for-primaquine-and-tafenoquine-in-the-radical-cure-of-vivax-malaria
#20
James Watson, Walter R J Taylor, Germana Bancone, Cindy S Chu, Podjanee Jittamala, Nicholas J White
BACKGROUND: The 8-aminoquinoline antimalarials, the only drugs which prevent relapse of vivax and ovale malaria (radical cure), cause dose-dependent oxidant haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with <30% and <70% of normal G6PD activity are not given standard regimens of primaquine and tafenoquine, respectively. Both drugs are currently considered contraindicated in pregnant and lactating women. METHODS: Quantitative G6PD enzyme activity data from 5198 individuals were used to estimate the proportions of heterozygous females who would be ineligible for treatment at the 30% and 70% activity thresholds, and the relationship with the severity of the deficiency...
April 20, 2018: PLoS Neglected Tropical Diseases
keyword
keyword
119365
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"