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https://www.readbyqxmd.com/read/27869305/analysis-of-falls-in-patients-with-epilepsy-enrolled-in-the-perampanel-phase-iii-randomized-double-blind-studies
#1
Ilo E Leppik, Haichen Yang, Betsy Williams, Sharon Zhou, Randi Fain, Anna Patten, Francesco Bibbiani, Antonio Laurenza
OBJECTIVE: To analyze occurrence of falls among patients with partial seizures, with/without secondarily generalized seizures (SGS), and primary generalized tonic-clonic seizures (PGTCS) in the perampanel phase III clinical studies. METHODS: Studies 304, 305, and 306 randomized subjects (≥12 years) with drug-resistant partial seizures (with/without SGS) to perampanel 2, 4, 8, or 12 mg or placebo for double-blind treatment. The adverse event (AE) of falls was analyzed in the Safety Analysis Set (N = 1480)...
November 21, 2016: Epilepsia
https://www.readbyqxmd.com/read/27843467/comparison-of-relation-between-attention-deficit-hyperactivity-disorder-in-children-with-and-without-simple-febrile-seizure-admitted-in-arak-central-iran
#2
Bahman Salehi, Parsa Yousefichaijan, Smira Safi Arian, Somaieh Ebrahimi, Mahdyieh Naziri
OBJECTIVE: Febrile seizure is one of the most prevalent childhood convulsions with the most common age of onset at 14-18 mo old. Fever decreases the brain threshold for seizure. Attention Deficit Hyperactivity Disorder (ADHD) is also a neurologic-behavioral problem defined by attention deficit and hyperactivity according to DSM-IV criteria in which the child must have these signs in two different environments. There is controversy on the possible relation between febrile seizure and ADHD; while some studies approve a strong relation, some exclude any relation and some attribute ADHD to the side effects of other reasons...
2016: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/27789949/managing-drug-resistant-epilepsy-challenges-and-solutions
#3
REVIEW
Linda Dalic, Mark J Cook
Despite the development of new antiepileptic drugs (AEDs), ~20%-30% of people with epilepsy remain refractory to treatment and are said to have drug-resistant epilepsy (DRE). This multifaceted condition comprises intractable seizures, neurobiochemical changes, cognitive decline, and psychosocial dysfunction. An ongoing challenge to both researchers and clinicians alike, DRE management is complicated by the heterogeneity among this patient group. The underlying mechanism of DRE is not completely understood. Many hypotheses exist, and relate to both the intrinsic characteristics of the particular epilepsy (associated syndrome/lesion, initial response to AED, and the number and type of seizures prior to diagnosis) and other pharmacological mechanisms of resistance...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27762437/symptomatic-and-presumed-symptomatic-focal-epilepsies-in-childhood-an-observational-prospective-multicentre-study
#4
Marilena Vecchi, Carmen Barba, Debora De Carlo, Micol Stivala, Renzo Guerrini, Emilio Albamonte, Domiziana Ranalli, Domenica Battaglia, Giada Lunardi, Clementina Boniver, Benedetta Piccolo, Francesco Pisani, Gaetano Cantalupo, Giuliana Nieddu, Susanna Casellato, Silvia Cappanera, Elisabetta Cesaroni, Nelia Zamponi, Domenico Serino, Lucia Fusco, Alessandro Iodice, Filippo Palestra, Lucio Giordano, Elena Freri, Ilaria De Giorgi, Francesca Ragona, Tiziana Granata, Isabella Fiocchi, Stefania Maria Bova, Massimo Mastrangelo, Alberto Verrotti, Sara Matricardi, Elena Fontana, Davide Caputo, Francesca Darra, Bernardo Dalla Bernardina, Francesca Beccaria, Giuseppe Capovilla, Maria Pia Baglietto, Alessandra Gagliardi, Aglaia Vignoli, Maria Paola Canevini, Egle Perissinotto, Stefano Francione
OBJECTIVE: To describe the clinical, neuropsychological, and psychopathologic features of a cohort of children with a new diagnosis of symptomatic or presumed symptomatic focal epilepsy at time of recruitment and through the first month. The selected population will be followed for 2-5 years after enrollment to investigate the epilepsy course and identify early predictors of drug resistance. METHODS: In this observational, multicenter, nationwide study, children (age 1 month-12...
November 2016: Epilepsia
https://www.readbyqxmd.com/read/27612082/identification-of-adhd-in-youth-with-epilepsy
#5
Mary C Kral, Michelle D Lally, Andrea D Boan
PURPOSE: To further characterize Attention-Deficit/Hyperactivity Disorder (ADHD) in a clinic-referred sample of youth with epilepsy. METHODS: Children and adolescents with epilepsy who were referred for comprehensive neuropsychological evaluation comprised the sample. Data were obtained via archival record review. Youth with epilepsy were grouped according to ADHD diagnosis (no ADHD, ADHD - Combined Type, and ADHD - Predominantly Inattentive Type) and compared for a number of neurocognitive variables, seizure-related variables, and parent and teacher completed behavior rating scale variables...
September 2, 2016: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/27444738/identification-of-mutations-in-ap4s1-spg52-through-next-generation-sequencing-in-three-families
#6
A Tessa, R Battini, A Rubegni, E Storti, C Marini, D Galatolo, R Pasquariello, F M Santorelli
BACKGROUND AND PURPOSE: The term hereditary spastic paraplegia (HSP) covers a spectrum of genetically heterogeneous disorders in which lower limb spasticity is the common clinical feature. Many patients with childhood-onset HSP are mistakenly diagnosed with cerebral palsy (CP). METHODS: A group of as yet molecularly undiagnosed HSP patients were analyzed using SpastoPlex, a customized target re-sequencing panel able to investigate the coding regions of 72 genes linked to HSP, spastic ataxias or related motor diseases...
October 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27218417/clinical-outcomes-in-children-with-herpes-simplex-encephalitis-receiving-steroid-therapy
#7
Hülya Maraş Genç, Emek Uyur Yalçın, Murat Sayan, Asuman Bayhan, Selim Öncel, Emin Sami Arısoy, Bülent Kara
BACKGROUND: Herpes simplex virus encephalitis (HSE) is a significant cause of morbidity and mortality. Neurologic sequelae are common even after early initiation of acyclovir treatment. The host immune response during HSE can also lead to brain damage. There are an increasing number of reports favoring steroid use in HSE. OBJECTIVES: We aimed to compare the prognosis of children with HSE with and without steroid therapy. STUDY DESIGN: We retrospectively screened our hospital archive from 2009 to 2014 for patients diagnosed with HSE with a positive result for herpes simplex virus polymerase chain reaction in cerebrospinal fluid...
July 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27132549/impact-of-extracorporeal-membrane-oxygenation-on-acute-fulminant-myocarditis-related-hemodynamic-compromise-arrhythmia-in-children
#8
Kuan-Miao Lin, Ming-Hsiu Li, Kai-Sheng Hsieh, Hsuan-Chang Kuo, Ming-Chou Cheng, Jiunn-Jye Sheu, Ying-Jui Lin
BACKGROUND: Acute fulminant myocarditis (AFM) commonly presents as abrupt cardiogenic shock with or without dysrhythmia. This study evaluated the impact of extracorporeal membrane oxygenation (ECMO) on AFM-related hemodynamic compromise dysrhythmias. We also reported the clinical experience of AFM at our hospital. METHODS: Eighteen children diagnosed with AFM were enrolled. Demographic variables, laboratory data, and clinical courses were reviewed. Thirteen surviving patients with hemodynamic compromise arrhythmia [complete atrioventricular block (CAVB) or ventricular tachycardia (VT)] during hospitalization were divided into Group A (ECMO group; n = 7) and Group B (non-ECMO group; n = 6)...
March 16, 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/27128787/pediatric-epilepsy-surgery-could-age-be-a-predictor-of-outcomes
#9
Benoit Jenny, Nicolas Smoll, Yassine El Hassani, Shahan Momjian, Claudio Pollo, Christian M Korff, Margitta Seeck, Karl Schaller
OBJECTIVE Like adults, many children suffering from intractable seizures benefit from surgical therapy. Although various reports indicate that early intervention may avoid severe developmental consequences often associated with intractable epilepsy, surgery is still considered a last option for many children. In this retrospective study, the authors aimed to determine whether pediatric epilepsy surgery, in particular during the first years of life, relates to measurable benefits. METHODS Data from 78 patients (age range 5 months to 17 years) who underwent epilepsy surgery at the Geneva and Lausanne University Hospitals between 1997 and 2012 were reviewed retrospectively...
August 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27119274/cerebral-venous-sinus-thrombosis-from-a-tertiary-care-teaching-hospital-in-india
#10
Jayantee Kalita, Satish Chandra, Bishwanath Kumar, Vikas Bansal, Usha K Misra
OBJECTIVE: The prognosis of cerebral venous sinus thrombosis (CVST) may be dependent on underlying causes and magnetic resonance imaging findings. We report the clinical, laboratory, and radiologic spectrum, and outcome of consecutive patients with CVST. METHODS: Consecutive patients with CVST over the last 15 years were subjected to detailed history, clinical examination, and laboratory tests as per fixed protocol. The diagnosis of CVST was based on MR venography...
May 2016: Neurologist
https://www.readbyqxmd.com/read/27111691/anesthetic-management-of-877-pediatric-patients-undergoing-muscle-biopsy-for-neuromuscular-disorders-a-20-year-review
#11
Frederic Shapiro, Umeshkumar Athiraman, David J Clendenin, Monica Hoagland, Navil F Sethna
BACKGROUND: The objectives are to review the anesthetic management and anesthetic-related adverse events in patients undergoing muscle biopsy for a broad spectrum of neuromuscular disorders (NMD). AIM: The study aims to assess the hypothesis that perceived awareness of potential anesthesia-induced hyperkalemia and MH in patients with NMD reduces the frequency of such events. METHODS: A 20-year retrospective review of 877 consecutive patients undergoing muscle biopsy to establish diagnoses of NMD has been performed...
July 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/27098266/antiepileptic-drugs-for-the-primary-and-secondary-prevention-of-seizures-after-intracranial-venous-thrombosis
#12
REVIEW
Michelle Price, Albrecht Günther, Joseph S K Kwan
BACKGROUND: Intracranial venous thrombosis (ICVT) commonly presents with seizures in the acute period, and some people may develop recurrent seizures in the long term. The prophylactic use of antiepileptic drugs (AEDs) for the management of post-ICVT seizures is controversial, and there is currently no consensus on the optimal management of post-ICVT seizures. This is an updated version of the Cochrane review first published in theCochrane Database of Systematic Reviews 2006, Issue 3...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27054905/is-high-dose-%C3%AE-lactam-therapy-associated-with-excessive-drug-toxicity-in-critically-ill-patients
#13
Craig McDonald, Menino O Cotta, Peter J Little, Brett McWhinney, Jacobus P Ungerer, Jeffrey Lipman, Jason A Roberts
BACKGROUND: β-lactam antibiotics may necessitate higher than licensed drug doses to achieve therapeutic exposures in critically ill patients. Therapeutic drug monitoring can be used to guide dosing so as to maximise therapeutic effect whilst reducing the likelihood of exposure-related toxicity. METHODS: A retrospective review of critically ill patients identified those that received higher than licensed doses of either meropenem (3-6 g/day) or piperacillin-tazobactam (16 g-2 g/day) (i...
September 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27012119/-efficiency-of-the-photostimulation-in-activation-of-the-eeg-paroxysmal-disorders-in-children-depending-on-frequency-spectrum-of-the-luminous-stimulus-preliminary-report
#14
Jolanta Strzelecka, Tymon Skadorwa, Barbara Kuszczak-Bohl
INTRODUCTION: Photostimulation is considered as a factor that may induce epileptic seizures, hence it has been implemented to neurological diagnostics in children as a component of electroencephalographic examination. The response to light stimulus is called photosensitivity. The impact of elimination of red light on the response to photostimulation has been widely discussed in current papers. However, there is no report concerning the Polish population. AIM: The aim of this study was to evaluate the efficacy of blue-filtered lenses (Z1) in children with photosensitivity...
2015: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/26995069/prevalence-and-characteristics-of-vaccination-triggered-seizures-in-dravet-syndrome-in-hong-kong-a-retrospective-study
#15
Polly Tsz Yan Wong, Virginia Chun-Nei Wong
BACKGROUND: Dravet syndrome is a rare epileptic encephalopathy characterized by treatment-resistant polymorphic seizures. Seizure onset usually occurs during the first year of life, and seizures are often associated with heat-related triggering factors (e.g., fever, photosensitivity, or hot bath). It has been reported that children with Dravet syndrome often present with recurrent febrile seizures and vaccination-related seizures. METHODS: We analyzed the occurrence of vaccination-related seizures (defined as the development of a seizure within 48 hours post vaccination) in 54 patients with Dravet syndrome...
May 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/26973811/the-value-of-the-history-and-physical-for-patients-with-newly-diagnosed-brain-metastases-considering-radiosurgery
#16
Ima Paydar, Eric Karl Oermann, Miriam Knoll, James Lee, Brian Timothy Collins, Matthew Ewend, Douglas Kondziolka, Sean P Collins
BACKGROUND: For patients with brain metastases, systemic disease burden has historically been accepted as a major determinant of overall survival (OS). However, less research has focused on specific history and physical findings made by clinicians and how such findings pertain to patient outcomes at a given time point. The aim of this study is to determine how the initial clinical assessment of patients with brain metastases, as part of the history and physical at the time of consultation, correlates to patient prognosis...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/26970995/frequency-of-restless-legs-syndrome-in-adults-with-epilepsy-in-turkey
#17
İlker Öztürk, Kezban Aslan, Hacer Bozdemir, Nancy Foldvary-Schaefer
BACKGROUND: Restless Legs Syndrome (RLS) is a common disorder characterized by an irresistible urge to move the legs particularly during rest in the evenings often leading to insomnia and daytime impairment. No prior studies estimate the prevalence of RLS in a diverse sample of adults with epilepsy using standard diagnostic criteria. MATERIAL AND METHOD: A total of 225 patients with epilepsy (61.8% female; mean age 33.3 ± 12.3 years) seen in the epilepsy clinic of Çukurova University Neurology Department were included...
April 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/26966821/factors-influencing-the-evaluation-and-management-of-neuromuscular-scoliosis-a-review-of-the-literature
#18
Simon B Roberts, Athanasios I Tsirikos
Neuromuscular scoliosis (NMS) is the second most prevalent spinal deformity (after idiopathic scoliosis) and is usually first identified during early childhood. Cerebral palsy (CP) is the most common cause of NMS, followed by Duchenne muscular dystrophy (DMD). Progressive spinal deformity causes difficulty with daily care, walking and sitting, and can lead to back and rib pain, cardiac and pulmonary complications, altered seizure thresholds, and skin compromise. Early referral to specialist spinal services and early diagnosis of NMS is essential to ensure appropriate multidisciplinary patient management...
November 21, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/26887856/electroconvulsive-therapy-in-women-a-retrospective-study-from-a-mental-health-hospital-in-turkey
#19
Armağan Özdemir, Cana Aksoy Poyraz, Evrim Erten, Emre Çırakoğlu, Nesrin Tomruk
The aim was to evaluate the clinical profile and effectiveness of ECT in women. A retrospective chart review was carried out to identify female patients who had received ECT during the period September 2013-February 2015. Details regarding their sociodemographic, clinical, and treatment data were extracted from these records for the present study. The total number of patients, admitted to our psychiatry inpatient clinic during the survey period, was 802. During this period, 26 (3.24 %) female patients received ECT...
February 18, 2016: Psychiatric Quarterly
https://www.readbyqxmd.com/read/26846755/moyamoya-disease-epidemiology-clinical-features-and-diagnosis
#20
REVIEW
Jong S Kim
Moyamoya disease (MMD) is a chronic, occlusive cerebrovascular disease characterized by progressive stenosis at the terminal portion of the internal carotid artery and an abnormal vascular network at the base of the brain. Although its etiology remains unknown, recent genetic studies identified RNF213 in the 17q25-ter region as an important susceptibility gene of MMD among East Asian populations. Possibly because of genetic differences, MMD is relatively common in people living in East Asian countries such as Korea and Japan, compared to those in the Western Hemisphere...
January 2016: Journal of Stroke
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