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hypercalcemia guidelines

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https://www.readbyqxmd.com/read/27849384/assessing-referrals-and-improving-information-availability-for-consultations-in-an-academic-endocrinology-clinic
#1
Chase D Hendrickson, Saumya Saini, Avin Pothuloori, John N Mecchella
OBJECTIVE: Outpatient specialty consultations rely on the timeliness and completeness of referral information to facilitate a valuable patient-specialist interaction. This project aimed to increase essential diagnostic information availability at the initial consultation for patients referred for common endocrine conditions frequently lacking such data - diabetes mellitus, thyroid nodule, thyrotoxicosis, and hypercalcemia. METHODS: At an endocrinology clinic at an academic medical center in rural New England, providers see several thousand new patients annually, the majority of whom are referred by providers external to the clinic's healthcare system...
November 16, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27758984/clinical-features-of-sarcoidosis-in-oman-a-report-from-the-middle-east-region
#2
B Jayakrishnan, Nasser Al-Busaidi, Ahsan Al-Lawati, Jojy George, Omar A Al-Rawas, Yaqoub Al-Mahrouqi, Nabil Al-Lawati
BACKGROUND: Though clinical features of sarcoidosis follow a similar pattern, some heterogeneity is seen in different ethnic and racial groups. OBJECTIVES: To describe for the first time the clinical characteristics of sarcoidosis patients in the Sultanate of Oman. METHODS: The data on all cases of sarcoidosis followed up in the two tertiary hospitals in Oman were retrieved retrospectively. RESULTS: Of the 92 patients, for representing the ethnic data only Omani patients (n=83) were included...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27698861/igm-multiple-myeloma-with-an-extremely-rare-non-aggressive-presentation-a-case-report
#3
Thomas Greuter, Martin Browne, Corina Dommann-Scherrer, Daniel Binder, Christoph Renner, Ursula Kapp
In the present study, the case of a 41-year-old man with immunoglobulin (Ig)M multiple myeloma (MM) that presented with an unusually non-aggressive clinical course who has survived for >9 years to date, is presented. Initial diagnosis of symptomatic MM was established according to the International Myeloma Working Group consensus statement and guidelines. Due to the mild symptoms, no therapy was administered and the patient was closely followed up. Eight years after initial diagnosis, clinical, morphological and genetic progression occurred with the development of hypercalcemia, progressively deteriorating polyneuropathy, clonal expansion of plasma cells up to 50% of hematopoietic cells and demonstration of the typical t(11;14) translocation (Ig heavy chain locus rearrangement)...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27613721/primary-hyperparathyroidism-review-and-recommendations-on-evaluation-diagnosis-and-management-a-canadian-and-international-consensus
#4
A A Khan, D A Hanley, R Rizzoli, J Bollerslev, J E M Young, L Rejnmark, R Thakker, P D'Amour, T Paul, S Van Uum, M Zakaria Shrayyef, D Goltzman, S Kaiser, N E Cusano, R Bouillon, L Mosekilde, A W Kung, S D Rao, S K Bhadada, B L Clarke, J Liu, Q Duh, E Michael Lewiecki, F Bandeira, R Eastell, C Marcocci, S J Silverberg, R Udelsman, K Shawn Davison, J T Potts, M L Brandi, J P Bilezikian
The purpose of this review is to assess the most recent evidence in the management of primary hyperparathyroidism (PHPT) and provide updated recommendations for its evaluation, diagnosis and treatment. A Medline search of "Hyperparathyroidism. Primary" was conducted and the literature with the highest levels of evidence were reviewed and used to formulate recommendations. PHPT is a common endocrine disorder usually discovered by routine biochemical screening. PHPT is defined as hypercalcemia with increased or inappropriately normal plasma parathyroid hormone (PTH)...
September 9, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27532155/a-retrospective-analysis-to-examine-factors-associated-with-mortality-in-medicare-beneficiaries-newly-diagnosed-with-multiple-myeloma
#5
Akeem A Yusuf, Tanya Natwick, Winifred Werther, Diana Felici, Maya Mahue, Kenneth R Bridges, Yi Peng
OBJECTIVE: Population-based data on mortality and associated factors in patients with multiple myeloma (MM) are limited. We examined the association between all-cause mortality and demographic and clinical characteristics in newly diagnosed MM patients treated with guideline-recommended chemotherapeutic agents. RESEARCH DESIGN AND METHODS: This retrospective cohort analysis used Medicare 20% data to create a cohort of adult (aged ≥18 years) newly diagnosed MM patients who received chemotherapy 2008-2011 and had no MM diagnosis in the 12 months before the disease index date...
September 16, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27098536/hypercalcemia-after-discontinuation-of-long-term-denosumab-treatment
#6
A S Koldkjær Sølling, T Harsløf, A Kaal, L Rejnmark, B Langdahl
UNLABELLED: Denosumab is used for treatment of osteoporosis. We present a case report of hypoparathyroid hypercalcemia and increased bone turnover associated with discontinuation of treatment for 10 years with denosumab. There is a need for evidence-based guidelines on discontinuation of long-term denosumab treatment to avoid side effects and preserving anti-fracture efficacy. PURPOSE: Denosumab is commonly used as an anti-resorptive agent for the treatment of osteoporosis...
July 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27038806/successful-conversion-from-parenteral-paricalcitol-to-pulse-oral-calcitriol-for-the-management-of-secondary-hyperparathyroidism-in-hemodialysis-patients
#7
Jennifer Kumar, Ngoc-Tram Gia Tran, John Schomberg, Elani Streja, Kamyar Kalantar-Zadeh, Madeleine Pahl
OBJECTIVE: The management of hyperparathyroidism in hemodialysis patients involves the administration of phosphate binders, vitamin D receptor activators, and calcimimetics. Intravenous paricalcitol has been preferred over oral calcitriol as it may cause less hypercalcemia and hyperphosphatemia. However, there is little data looking at the efficacy and tolerability of oral calcitriol in the calcimimetic era particularly in a real practice-based experience. The University of California, Irvine free-standing dialysis center converted from routine intravenous paricalcitol to oral calcitriol due to pharmacy purchasing preferences...
July 2016: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/26952689/a-novel-calcium-infusion-regimen-after-parathyroidectomy-for-renal-hyperparathyroidism
#8
Tan Jih Huei, Henry Tan Chor Lip, Loke Seng Cheong, Sarojah A/P Arulanantham
AIM: Calcium infusion is used after parathyroid surgery for renal hyperparathyroidism to treat post-operative hypocalcaemia. We compared a new infusion regimen to one commonly used in Malaysia based on 2003 K/DOQI guidelines. METHODS: Retrospective data on serum calcium and infusion rates was collected from 2011-2015. The relationship between peak calcium efflux (PER) and time was determined using a scatterplot and linear regression. A comparison between regimens was made based on treatment efficacy (hypocalcaemia duration, total infusion amount and time) and calcium excursions (outside target range, peak and trough calcium) using bar charts and an unpaired T-test...
March 8, 2016: Nephrology
https://www.readbyqxmd.com/read/26921840/the-influence-of-thiazide-intake-on-calcium-and-parathyroid-hormone-levels-in-patients-with-primary-hyperparathyroidism
#9
Philipp Riss, Michael Kammer, Andreas Selberherr, Christoph Bichler, Reto Kaderli, Christian Scheuba, Bruno Niederle
OBJECTIVE: The effects of thiazide medication in patients with primary hyperparathyroidism (PHPT) have so far not been elucidated. The aim of this study was to analyse the extent to which the administration of thiazides may influence biochemical parameters and therefore the diagnosis of PHPT in a large cohort of patients. DESIGN AND PATIENTS: The biochemical parameters of 1066 patients with PHPT were analysed, and drug history was documented. Calcium (Ca)/creatinine clearance ratio (CCCR) was calculated...
August 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/26822333/-changes-in-mineral-and-bone-disorder-management-in-a-french-cohort-of-hemodialysis-patients-between-2008%C3%A2-and-2012-the-national-bone-and-mineral-metabolism-observatory-photo-graphe%C3%A2-2%C3%A2-and%C3%A2-3
#10
Solenne Pelletier, Hubert Roth, Jean-Louis Bouchet, Tilman B Drueke, Thierry Hannedouche, Guillaume Jean, Gérard London, Denis Fouque
INTRODUCTION: Chronic kidney disease progressively induces a disorder of mineral and bone metabolism (CKD-MBD) which also leads to cardiovascular abnormalities. Previous studies showed that only few hemodialysis patients had serum calcium, phosphate and parathyroid hormone levels within the K/DOQI (Kidney-Disease Outcomes Quality Initiative) targets of 2003. Our aim was to identify the impact of different therapeutic strategies and that of the KDIGO (Kidney-Disease: Improving Global Outcomes) targets of 2009 on the control of CKD-MBD...
June 2016: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/26668024/sevelamer-versus-calcium-based-binders-for-treatment-of-hyperphosphatemia-in-ckd-a-meta-analysis-of-randomized-controlled-trials
#11
Leena Patel, Lisa M Bernard, Grahame J Elder
BACKGROUND AND OBJECTIVES: People with CKD stages 3-5 and on dialysis (5D) have dramatically increased mortality, which has been associated with hyperphosphatemia in many studies. Oral phosphate binders are commonly prescribed to lower serum phosphate. We conducted an updated meta-analysis of the noncalcium-based binder (non-CBB) sevelamer versus CBBs in CKD stages 3-5D. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Randomized, controlled trials comparing sevelamer with CBBs were identified through MEDLINE and the Cochrane Central Register of Controlled Trials...
February 5, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/26439891/treatment-failure-of-active-vitamin-d-therapy-in-chronic-kidney-disease-predictive-factors
#12
REVIEW
Mario Cozzolino, Adrian Covic, Blanca Martinez-Placencia, Konstantinos Xynos
BACKGROUND: In patients with chronic kidney disease (CKD), impaired renal function leads to decreased vitamin D levels, which causes an increase in parathyroid hormone (PTH) production and contributes to the development of secondary hyperparathyroidism (SHPT). This may result in adverse clinical effects such as bone disorders, vascular calcification, cardiovascular disease, and increased mortality. Current treatment practices and associated outcomes with active vitamin D treatment in patients with CKD were reviewed with the objective to assess parameters (such as PTH and serum calcium levels) that may be used to define the failure of vitamin D treatment...
2015: American Journal of Nephrology
https://www.readbyqxmd.com/read/26375759/associations-among-time-average-mineral-values-mortality-and-cardiovascular-events-in-hemodialysis-patients
#13
Hung-Chieh Wu, Lin-Chien Lee, Wei-Jie Wang
UNLABELLED: Mineral and bone disease (CKD-MBD), disorders of mineral metabolism, is associated with mortality and cardiovascular disease in dialysis patients. However, the associations among time average mineral values (P, Ca and PTH) and clinical outcomes are not well investigated. OBJECTIVES: This study examines the associations among mineral values and clinical outcomes from a single medical center. METHODS: Adult patients who initiate hemodialysis in Taoyuan General Hospital from 2008 to 2013 were enrolled...
November 2015: Renal Failure
https://www.readbyqxmd.com/read/26147627/biological-impact-of-recent-guidelines-on-parenteral-nutrition-in-preterm-infants
#14
REVIEW
Isabelle Guellec, Géraldine Gascoin, Alain Beuchee, Farid Boubred, Pierre Tourneux, Duksha Ramful, Elodie Zana-Taieb, Olivier Baud
OBJECTIVES: Recent guidelines for preterm neonates recommend early initiation of parenteral nutrition (PN) with high protein and relatively high caloric intake. This review considers whether these changes could influence homeostasis in very preterm infants during the first few postnatal weeks. METHODS: This systematic review of relevant literature from searches of PubMed and recent guidelines was reviewed by investigators from several perinatal centers in France...
December 2015: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/26141804/-vitamin-d-supplementation-not-too-much-not-too-little
#15
S Hamo, C Freychet, A Bertholet-Thomas, A-L Poulat, P Cochat, C Vuillerot, J Bacchetta
Vitamin D deficiency is common in the general population and even more frequent in patients with chronic diseases. The prevention of rickets with native vitamin D supplementation is one of the oldest and most effective prophylactic measures ever reported in medicine, leading to an almost complete eradication of vitamin D-deficient rickets in developed countries. We report on two children with vitamin D abnormalities: the first, 10-year-old child developed rickets without any vitamin D supplementation despite different risk factors (autism, ethnicity, nutritional problems, chronic antiepileptic therapies)...
August 2015: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/26087218/-agressive-small-cell-carcinoma-of-the-ovary-hypercalcemic-type-surgery-and-oncological-treatment-case-report
#16
M Kapoun, J Bouda, J Presl, P Vlasák, R Slunečko
Small cell carcinoma of the ovary (SCCOHT) is a rare tumor typically affecting young women. It is a highly malignant tumor accompanied with poor prognosis, early relapse and low survival rates. The most significant prognostic factor is stage of the disease. Due to above mentioned factors there are no guidelines for therapy of this rare tumor. We present a case of 22-years-old patient initially treated with antibiotics under diagnosis of pelvic inflammatory disease. Due to persistent mass at left adnexa, she was indicated for diagnostic laparoscopy, converted to laparotomy and left adnexectomy with frozen section revealing unspecified malignant tumor of left ovary...
June 2015: Ceská Gynekologie
https://www.readbyqxmd.com/read/26032778/contemporary-management-of-phosphorus-retention-in-chronic-kidney-disease-a-review
#17
REVIEW
Fateme Shamekhi Amiri
Hyperphosphatemia is the most common metabolic complications of end-stage kidney disease (ESKD). Large observational studies have identified hyperphosphatemia as an independent risk factor for cardiovascular disease and mortality in dialysis patients and subsequent studies found that subtle increases in serum phosphate levels even within the normal range are also associated with increased risk for death in predialysis and non-kidney disease population. On the basis of these results, current national practice guidelines advocate more aggressive treatment of hyperphosphatemia to lower serum phosphate targets than in the past ...
December 2015: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/25988555/electrolyte-and-mineral-homeostasis-after-optimizing-early-macronutrient-intakes-in-vlbw-infants-on-parenteral-nutrition
#18
Thibault Senterre, Ibrahim Abu Zahirah, Catherine Pieltain, Virginie de Halleux, Jacques Rigo
OBJECTIVES: The aim of the present study was to evaluate electrolyte and mineral homeostasis in very-low-birth-weight (VLBW) infants who received high protein and energy intakes with a unique standardized parenteral nutrition solution containing electrolytes and minerals from birth onward. METHODS: Prospective cohort study in 102 infants with birth weight <1250 g. The evolution of plasma biochemical parameters was described during the first 2 weeks of life. RESULTS: During the first 3 days of life, mean parenteral intakes were 51 ± 8 kcal · kg · day with 2...
October 2015: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/25963841/the-effect-of-active-vitamin-d-on-cardiovascular-outcomes-in-predialysis-chronic-kidney-diseases-a-systematic-review-and-meta-analysis
#19
Xiao-Hua Li, Li Feng, Zhen-Hua Yang, Yun-Hua Liao
AIMS: Vitamin D deficient patients present an increased risk of cardiovascular disease. We conducted this systematic review and meta-analysis to evaluate the effect of active vitamin D analog on cardiovascular outcomes in predialysis chronic kidney disease. METHODS: Pubmed, Embase, the Cochrane Library, CNKI, and article reference lists were searched for RCTs that compared active vitamin D analogs with placebo or no treatment for patients with predialysis chronic kidney disease...
May 12, 2015: Nephrology
https://www.readbyqxmd.com/read/25924757/diagnosis-and-management-of-patients-with-hypercalcaemia
#20
Jennie Walker
Hypercalcaemia is a common biochemical abnormality in the blood that can be caused by malignancy, hyperparathyroidism, medications or underlying medical conditions. Initial signs and symptoms are often vague, however, if someone has severe hypercalcaemia it is treated as an emergency, requiring prompt management to prevent life-threatening complications such as dehydration, cardiac arrhythmias or coma. Understanding the pathophysiology, signs and symptoms of hypercalcaemia enables effective diagnosis and holistic management of the patient with complex health needs...
May 2015: Nursing Older People
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