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https://www.readbyqxmd.com/read/29416342/increased-risk-of-venous-thromboembolism-associated-with-polymyositis-and-dermatomyositis-a-meta-analysis
#1
REVIEW
Yanqing Li, Peihong Wang, Lei Li, Fei Wang, Yuxiu Liu
Objective: Polymyositis and dermatomyositis (PM/DM) have been implicated in the development of venous thromboembolism (VTE). Previous studies investigating the association between PM/DM and VTE risk had yielded inconsistent findings. The aim of this study was to precisely estimate this association by meta-analysis of all available publications. Methods: Two investigators independently performed a comprehensive literature search in databases of PubMed, Embase, and the Cochrane Library for eligible studies...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29297205/cyclophosphamide-for-connective-tissue-disease-associated-interstitial-lung-disease
#2
REVIEW
Hayley Barnes, Anne E Holland, Glen P Westall, Nicole Sl Goh, Ian N Glaspole
BACKGROUND: Approximately one-third of individuals with interstitial lung disease (ILD) have associated connective tissue disease (CTD). The connective tissue disorders most commonly associated with ILD include scleroderma/systemic sclerosis (SSc), rheumatoid arthritis, polymyositis/dermatomyositis, and Sjögren's syndrome. Although many people with CTD-ILD do not develop progressive lung disease, a significant proportion do progress, leading to reduced physical function, decreased quality of life, and death...
January 3, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29100298/assessment-of-anti-mda5-antibody-as-a-diagnostic-biomarker-in-patients-with-dermatomyositis-associated-interstitial-lung-disease-or-rapidly-progressive-interstitial-lung-disease
#3
Liubing Li, Qian Wang, Xiaoting Wen, Chenxi Liu, Chanyuan Wu, Funing Yang, Xiaofeng Zeng, Yongzhe Li
Anti-melanoma differentiation-associated protein 5 (MDA5) antibody have been found in dermatomyositis (DM)-associated interstitial lung disease (DM-ILD) and DM-associated rapidly progressive ILD (DM-RPILD). Due to the conflicting results regarding the association between anti-MDA5 antibody and DM-ILD or DM-RPILD and the diagnostic value of this antibody for DM-ILD and DM-RPILD, we performed this meta-analysis. A systematic search was performed to identify studies published to January 14, 2017. Sixteen publications with 491 DM with ILD versus 605 DM without ILD, as well as eighteen publications with 186 DM with RPILD and 790 DM without RPILD were included...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28983955/associations-between-anti-melanoma-differentiation-associated-gene-5-antibody-and-demographics-clinical-characteristics-and-laboratory-results-of-patients-with-dermatomyositis-a-systematic-meta-analysis
#4
Ju Li, Yan Liu, Yongsheng Li, Fang Li, Kai Wang, Wenyou Pan, Deqian Meng
Anti-melanoma differentiation-associated gene 5 (MDA5) antibody is a specific biomarker in patients with dermatomyositis (DM). Results from several studies that examined the relationship between anti-MDA5 antibody and the demographics, clinical characteristics and laboratory results of DM patients have been conflicting. The purpose of this study was to identify the relationship, if any, of anti-MDA5 antibody with demographics, clinical characteristics and laboratory results of DM patients. PubMed, Web of Science, Embase and the Cochrane Library databases were searched for studies without language restrictions conducted before 16 March 2017...
January 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/28871260/dermatomyositis-and-immune-mediated-necrotizing-myopathies-a-window-on-autoimmunity-and-cancer
#5
REVIEW
Audrey Aussy, Olivier Boyer, Nadège Cordel
Autoimmune myopathies (myositides) are strongly associated with malignancy. The link between myositis and cancer, originally noticed by Bohan and Peter in their classification in 1975 (1), has been evidenced by large population-based cohort studies and a recent meta-analysis. The numerous reports of cases in which the clinical course of myositis reflects that of cancer and the short delay between myositis and cancer onset support the notion that myositis may be an authentic paraneoplastic disorder. Thus, cancer-associated myositis raises the question of cancer as a cause rather than a consequence of autoimmunity...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28722667/assessment-of-anti-mda5-antibody-as-a-diagnostic-biomarker-in-patients-with-dermatomyositis-associated-interstitial-lung-disease-or-rapidly-progressive-interstitial-lung-disease
#6
Liubing Li, Qian Wang, Xiaoting Wen, Chenxi Liu, Chanyuan Wu, Funing Yang, Xiaofeng Zeng, Yongzhe Li
Anti-melanoma differentiation-associated protein 5 (MDA5) antibody have been found in dermatomyositis (DM)-associated interstitial lung disease (DM-ILD) and DM-associated rapidly progressive ILD (DM-RPILD). Due to the conflicting results regarding the association between anti-MDA5 antibody and DM-ILD or DM-RPILD and the diagnostic value of this antibody for DM-ILD and DM-RPILD, we performed this meta-analysis. A systematic search was performed to identify studies published to January 14, 2017. Sixteen publications with 491 DM with ILD versus 605 DM without ILD, as well as eighteen publications with 186 DM with RPILD and 790 DM without RPILD were included...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28704599/anti-tif1-gamma-antibodies-are-not-associated-with-other-paraneoplastic-rheumatic-syndromes-than-dermatomyositis
#7
Paulius Venalis, Sandra Selickaja, Karin Lundberg, Rita Rugiene, Ingrid E Lundberg
OBJECTIVES: An association between cancer and dermatomyositis (DM) is well recognized. The high frequency of malignancies detected close to DM diagnosis suggests that DM can be a paraneoplastic syndrome. Recently anti-TIF1-gamma has been discovered to be associated with cancer and DM. A meta-analysis claimed pooled sensitivity of anti-p155 for diagnosing cancer-associated DM to be 78% and specificity to be 89%. Thus anti-TIF1-gamma has shown promising results as a marker forcancer-associated DM ...
July 13, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28493173/idiopathic-inflammatory-myopathy-and-the-risk-of-venous-thromboembolism-a-meta-analysis
#8
Young Ho Lee, Gwan Gyu Song
This study aimed at analyzing published data on the association between idiopathic inflammatory myopathy and venous thromboembolism (VTE). We examined studies on VTE risk in patients with polymyositis (PM) and/or dermatomyositis (DM), in the MEDLINE, EMBASE, and Cochrane databases and via manual searches. We performed a meta-analysis on the relative risks (RRs) of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in these patients. Five studies, including 8858 patients with PM/DM met the inclusion criteria...
July 2017: Rheumatology International
https://www.readbyqxmd.com/read/27856478/prognostic-factors-of-idiopathic-inflammatory-myopathies-complicated-with-interstitial-lung-disease-protocol-for-a-systematic-review-and-meta-analysis
#9
Hiroyuki Kamiya, Ogee Mer Panlaqui, Shinyu Izumi, Takashi Sozu
INTRODUCTION: Idiopathic inflammatory myopathies may be an overlapping disease complex. Although interstitial lung disease affects the mortality and the morbidity of the disease, a clinical course and the prognosis of the disease complicated with interstitial lung disease are diverse among individuals and prognostic factors have yet to be clarified. This article aims to report the rationale and the methodology of a future intended systematic review and meta-analysis of prognostic factors of idiopathic inflammatory myopathies complicated with interstitial lung disease...
November 17, 2016: BMJ Open
https://www.readbyqxmd.com/read/27534779/risk-of-malignancy-in-dermatomyositis-and-polymyositis
#10
REVIEW
Judy K Qiang, Whan B Kim, Akerke Baibergenova, Raed Alhusayen
BACKGROUND: There is variation in the risk of malignancy in dermatomyositis (DM) and polymyositis (PM) in the existing literature. OBJECTIVE: To conduct a meta-analysis to estimate the risk of malignancy in DM and PM as compared with the general population. METHODS: Medline and Embase Database abstracts were searched through August 2014 using the search terms myositis, neoplasms, and paraneoplastic syndromes. Population-based, observational studies in English were included...
March 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27171228/factors-associated-with-interstitial-lung-disease-in-patients-with-polymyositis-and-dermatomyositis-a-systematic-review-and-meta-analysis
#11
REVIEW
Li Zhang, Guoqin Wu, Di Gao, Guijian Liu, Lin Pan, Liyan Ni, Zheng Li, Qiang Wang
OBJECTIVES: Interstitial lung disease (ILD) is an extramuscular manifestation that results in increased morbidity and mortality from polymyositis (PM) and dermatomyositis (DM). The aim of this study was to systematically evaluate risk factors associated with the development of ILD in PM/DM. METHODS: Observational studies were identified from searching PubMed, Medline, Embase, and the Cochrane Library. Pooled odds ratios (ORs) or standardized mean differences (SMDs) and corresponding 95% confidence intervals (CIs) were obtained for the relationships between risk factors and ILD in PM/DM using either fixed- or random-effects models, whichever were appropriate...
2016: PloS One
https://www.readbyqxmd.com/read/25774016/cost-utility-analysis-of-intravenous-immunoglobulin-for-the-treatment-of-steroid-refractory-dermatomyositis-in-thailand
#12
Naruemon Bamrungsawad, Nathorn Chaiyakunapruk, Nilawan Upakdee, Chayanin Pratoomsoot, Rosarin Sruamsiri, Piyameth Dilokthornsakul
INTRODUCTION: Intravenous immunoglobulin (IVIG) has been shown to be effective in treating steroid-refractory dermatomyositis (DM). There remains no evidence of its cost-effectiveness in Thailand. OBJECTIVE: Our objective was to estimate the cost utility of IVIG as a second-line therapy in steroid-refractory DM in Thailand. METHODS: A Markov model was developed to estimate the relevant costs and health benefits for IVIG plus corticosteroids in comparison with immunosuppressant plus corticosteroids in steroid-refractory DM from a societal perspective over a patient's lifetime...
May 2015: PharmacoEconomics
https://www.readbyqxmd.com/read/25721032/cancer-risk-in-dermatomyositis-a-meta-analysis-of-cohort-studies
#13
Jeannette M Olazagasti, Pedro J Baez, David A Wetter, Floranne C Ernste
BACKGROUND: An association between dermatomyositis (DM) and cancer has been reported since 1916; however, estimates of the associated risk vary widely. For cost-effectiveness reasons it might be important to elucidate the degree of overall cancer risk in DM. OBJECTIVE: The aim of this systematic review was to investigate the association of cancer in DM by performing a meta-analysis of cohort studies. DATA SOURCES: A systematic literature search of PubMed, Ovid MEDLINE, EMBASE, Web of Science, Scopus, and the Cochrane Collaboration was conducted without language restriction, to 1 May 2014...
April 2015: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/25354465/risk-of-ischemic-stroke-in-patients-with-polymyositis-and-dermatomyositis-a-systematic-review-and-meta-analysis
#14
REVIEW
Patompong Ungprasert, Wisit Cheungpasitporn, Karn Wijarnpreecha, Wasin Ahuja, Praveen Ratanasrimetha, Charat Thongprayoon
Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, have been demonstrated to increase ischemic stroke risk, but the data on polymyositis (PM) and dermatomyositis (DM) remain unclear. We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio or standardized incidence ratio comparing ischemic risk in patients with PM/DM versus non-PM/DM participants. Pooled risk ratio and 95 % confidence intervals were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird...
May 2015: Rheumatology International
https://www.readbyqxmd.com/read/25101759/associations-between-tnf-%C3%AE-308a-g-polymorphism-and-susceptibility-with-dermatomyositis-a-meta-analysis
#15
Si Chen, Qian Wang, Ziyan Wu, Qingjun Wu, Ping Li, Yuan Li, Jing Li, Chuiwen Deng, Chanyuan Wu, Lei Gao, Fengchun Zhang, Yongzhe Li
BACKGROUND: Some surveys had inspected the effects of the tumor necrosis factor-α (TNF-α)-308A/G polymorphism on susceptibility to dermatomyositis (DM), and showed mixed results. To briefly review these consequences, a comprehensive meta-analysis was carried out to estimate the relationship between them much more accurately. METHODS: Relevant documents dated to February 2014 were acquired from the PUBMED, MEDLINE, and EMBASE databases. The number of the genotypes and/or alleles for the TNF-α-308A/G in the DM and control subjects was extracted and statistical analysis was conducted using STATA 11...
2014: PloS One
https://www.readbyqxmd.com/read/24713868/factors-predicting-malignancy-in-patients-with-polymyositis-and-dermatomyostis-a-systematic-review-and-meta-analysis
#16
REVIEW
Xin Lu, Hanbo Yang, Xiaoming Shu, Fang Chen, Yinli Zhang, Sigong Zhang, Qinglin Peng, Xiaolan Tian, Guochun Wang
OBJECTIVE: To define potential factors that could predict concomitant neoplastic diseases in patients diagnosed with PM/DM, which could inform screening decisions. METHODS: Two researchers independently reviewed articles from Pubmed (MEDLINE), EMBASE, Cochrane Plus Library and ISI Web of Knowledge with no restrictions on study design or language. Given that some of the studies combined PM and DM patients as research subjects while others included only DM patients, data were subjected to meta-analyses for all combined PM/DM studies and studies that included only DM patients to obtain informative results...
2014: PloS One
https://www.readbyqxmd.com/read/24704867/the-clinical-phenotype-associated-with-myositis-specific-and-associated-autoantibodies-a-meta-analysis-revisiting-the-so-called-antisynthetase-syndrome
#17
REVIEW
Jean-Christophe Lega, Nicole Fabien, Quitterie Reynaud, Isabelle Durieu, Stéphane Durupt, Marine Dutertre, Jean-François Cordier, Vincent Cottin
OBJECTIVE: To describe the clinical spectrum associated with aminoacyl-transfer RNA synthetase (ARS) autoantibodies in patients with idiopathic inflammatory myositis defined according to Peter and Bohan's criteria. METHODS: Cohort studies were selected from MEDLINE and Embase up to August 2013. Two investigators independently extracted data on study design, patient characteristics, and clinical features (interstitial lung disease [ILD], fever, mechanic's hands [MH], Raynaud's phenomenon [RPh], arthralgia, sclerodactyly, cancer and dermatomyositis-specific rash) according to the presence of myositis-specific (anti-aminoacyl-transfer RNA synthetase [ARS], anti-signal recognition particle [anti-SRP] and anti-Mi2) and myositis-associated (anti-PM/Scl, anti-U1-RNP and anti-Ku) autoantibodies...
September 2014: Autoimmunity Reviews
https://www.readbyqxmd.com/read/24684974/risk-of-coronary-artery-disease-in-patients-with-idiopathic-inflammatory-myopathies-a-systematic-review-and-meta-analysis-of-observational-studies
#18
REVIEW
Patompong Ungprasert, Promporn Suksaranjit, Ittikorn Spanuchart, Napat Leeaphorn, Nitipong Permpalung
OBJECTIVES: To investigate the risk of coronary artery disease in patients with idiopathic inflammatory myopathies (IIM). METHODS: We conducted a systematic review and meta-analysis of observational studies that reported odds ratios, relative risks, hazard ratios, or standardized incidence ratios comparing the risk of coronary artery disease in patients with IIM versus non-IIM participants. We searched published studies indexed in MEDLINE, EMBASE, and the Cochrane database from inception to December 2013 using the terms "coronary artery disease" OR "coronary heart disease" OR "myocardial infarction" OR "atherosclerosis" combined with the terms "dermatomyositis" OR "polymyositis" OR "Idiopathic inflammatory myopathy...
August 2014: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/23909921/meta-analysis-of-the-association-of-dermatomyositis-and-polymyositis-with-cancer
#19
J Wang, G Guo, G Chen, B Wu, L Lu, L Bao
BACKGROUND: Although some features of dermatomyositis (DM) and polymyositis (PM) have been reported as possible prognostic indicators for cancer development, previous studies were small in size and were unable to establish a definitive relationship between neoplasms and DM and PM. OBJECTIVES: To evaluate risk factors for developing malignancies in patients with DM and PM. METHODS: Meta-analysis of the studies reported in the literature was performed to unveil risk factors for developing cancer among patients with DM and PM...
October 2013: British Journal of Dermatology
https://www.readbyqxmd.com/read/23908005/utility-of-anti-melanoma-differentiation-associated-gene-5-antibody-measurement-in-identifying-patients-with-dermatomyositis-and-a-high-risk-for-developing-rapidly-progressive-interstitial-lung-disease-a-review-of-the-literature-and-a-meta-analysis
#20
REVIEW
Zhiyong Chen, Mengshu Cao, Maria Nieves Plana, Jun Liang, Hourong Cai, Masataka Kuwana, Lingyun Sun
OBJECTIVE: To assess the utility of anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody measurement for predicting a risk for developing rapidly progressive interstitial lung disease (RP-ILD) in patients with polymyositis/dermatomyositis (PM/DM). METHODS: A single-center cohort of 64 consecutive Chinese patients with PM/DM was examined. Serum anti-MDA5 antibody was measured by enzyme-linked immunosorbent assay. For meta-analysis, we searched PubMed and the Institute for Scientific Information Web of Knowledge for original studies that measured anti-MDA5 antibodies in patients with PM/DM...
August 2013: Arthritis Care & Research
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