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analgesic in brain tumors

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https://www.readbyqxmd.com/read/27094782/biphalin-preferentially-recruits-peripheral-opioid-receptors-to-facilitate-analgesia-in-a-mouse-model-of-cancer-pain-a-comparison-with-morphine
#1
Anna Lesniak, Marta Bochynska-Czyz, Mariusz Sacharczuk, Sandor Benhye, Aleksandra Misicka, Magdalena Bujalska-Zadrozny, Andrzej W Lipkowski
The search for new drugs for cancer pain management has been a long-standing goal in basic and clinical research. Classical opioid drugs exert their primary antinociceptive effect upon activating opioid receptors located in the central nervous system. A substantial body of evidence points to the relevance of peripheral opioid receptors as potential targets for cancer pain treatment. Peptides showing limited blood-brain-barrier permeability promote peripheral analgesia in many pain models. In the present study we examined the peripheral and central analgesic effect of intravenously administered biphalin - a dimeric opioid peptide in a mouse skin cancer pain model, developed by an intraplantar inoculation of B16F0 melanoma cells...
June 30, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26894804/analgesic-use-and-the-risk-of-primary-adult-brain-tumor
#2
Kathleen M Egan, Louis B Nabors, Zachary J Thompson, Carrie M Rozmeski, Gabriella A Anic, Jeffrey J Olson, Renato V LaRocca, Sajeel A Chowdhary, Peter A Forsyth, Reid C Thompson
Glioma and meningioma are uncommon tumors of the brain with few known risk factors. Regular use of aspirin has been linked to a lower risk of gastrointestinal and other cancers, though evidence for an association with brain tumors is mixed. We examined the association of aspirin and other analgesics with the risk of glioma and meningioma in a large US case-control study. Cases were persons recently diagnosed with glioma or meningioma and treated at medical centers in the southeastern US. Controls were persons sampled from the same communities as the cases combined with friends and other associates of the cases...
September 2016: European Journal of Epidemiology
https://www.readbyqxmd.com/read/26871201/perioperative-pregabalin-for-reducing-pain-analgesic-consumption-and-anxiety-and-enhancing-sleep-quality-in-elective-neurosurgical-patients-a-prospective-randomized-double-blind-and-controlled-clinical-study
#3
Nir Shimony, Uri Amit, Bella Minz, Rachel Grossman, Marc A Dany, Lior Gonen, Karina Kandov, Zvi Ram, Avi A Weinbroum
OBJECTIVE The aim of this study was to assess in-hospital (immediate) postoperative pain scores and analgesic consumption (primary goals) and preoperative anxiety and sleep quality (secondary goals) in patients who underwent craniotomy and were treated with pregabalin (PGL). Whenever possible, out-of-hospital pain scores and analgesics usage data were obtained as well. METHODS This prospective, randomized, double-blind and controlled study was conducted in consenting patients who underwent elective craniotomy for brain tumor resection at Tel Aviv Medical Center between 2012 and 2014...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/26753538/symptoms-and-management-of-pediatric-patients-with-incurable-brain-tumors-in-palliative-home-care
#4
Michaela Kuhlen, Jessica Hoell, Stefan Balzer, Arndt Borkhardt, Gisela Janssen
INTRODUCTION: Brain tumors have the highest disease-related mortality rate of all pediatric cancers. The goal of this study was to determine whether all children with incurable brain tumors cared for by a pediatric palliative care team in a home setting suffer from the same symptoms towards the end of their lives or whether there are differences between the tumor localizations with implications for palliative care. PATIENTS AND METHODS: This study was conducted as a retrospective, single center chart review including all patients treated between January 1st 2000 and December 31st 2013...
March 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/26655164/neuroprotective-effects-of-dexmedetomidine-conditioning-strategies-evidences-from-an-in-vitro-model-of-cerebral-ischemia
#5
Raquel Rodríguez-González, Tomás Sobrino, Sonia Veiga, Pablo López, Javier Rodríguez-García, Sonia Veiras del Río, Aurora Baluja, José Castillo, Julián Álvarez
AIMS: Dexmedetomidine is a selective agonist of α2-adrenergic receptors with clinical anesthetic and analgesic properties that has also shown neuroprotective effects on several models of brain injury. Because perioperative stroke and brain damage are frequent causes of death in critical care units, we aimed to investigate neuroprotective properties of dexmedetomidine using an in vitro model of cerebral ischemia. MAIN METHODS: Primary mixed rat brain cortical cultures were subjected to oxygen and glucose deprivation and treated with different doses of dexmedetomidine in order to analyze three conditioning strategies: preconditioning, intraconditioning and postconditioning...
January 1, 2016: Life Sciences
https://www.readbyqxmd.com/read/26377394/chronic-oxycodone-induces-integrated-stress-response-in-rat-brain
#6
Ruping Fan, Lisa M Schrott, Stephen Snelling, Julius Ndi, Thomas Arnold, Nadejda L Korneeva
BACKGROUND: Oxycodone is an opioid that is prescribed to treat multiple types of pain, especially when other opioids are ineffective. Unfortunately, similar to other opioids, repetitive oxycodone administration has the potential to lead to development of analgesic tolerance, withdrawal, and addiction. Studies demonstrate that chronic opioid exposure, including oxycodone, alters gene expression profiles and that these changes contribute to opioid-induced analgesic effect, tolerance and dependence...
September 16, 2015: BMC Neuroscience
https://www.readbyqxmd.com/read/26325514/the-effects-of-dexmedetomidine-and-remifentanil-on-hemodynamic-stability-and-analgesic-requirement-after-craniotomy-a-randomized-controlled-trial
#7
Shobana Rajan, Matthew T Hutcherson, Daniel I Sessler, Andrea Kurz, Dongsheng Yang, Michael Ghobrial, Jinbo Liu, Rafi Avitsian
BACKGROUND: Anesthesia for craniotomies should blunt responses to noxious stimuli, whereas subsequently leaving patients sufficiently alert for early neurological evaluation. The aim was to compare postoperative blood pressure control, pain, and opioid requirement after anesthesia with dexmedetomidine versus remifentanil. We therefore tested 2 primary hypotheses: (1) intraoperative administration of dexmedetomidine provides better control of postoperative blood pressure than remifentanil; and (2) patients given dexmedetomidine have less postoperative pain and use less opioid...
October 2016: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/26119705/mu-opioid-receptor-activation-enhances-regulator-of-g-protein-signaling-4-association-with-the-mu-opioid-receptor-g-protein-complex-in-a-gtp-dependent-manner
#8
Rema Santhappan, Alicia Tamara Crowder, Shawn Gouty, Brian M Cox, Thomas E Côté
The interaction of Regulator of G protein Signaling 4 (RGS4) with the rat mu opioid receptor (MOR)/G protein complex was investigated. Solubilized MOR from rat brain membranes was immunoprecipitated in the presence of RGS4 with antibodies against the N-terminus of MOR (anti-MOR10-70 ). Activation of MOR with [D-Ala(2) , N-Me-Phe(4) , Gly(5) -ol] enkephalin (DAMGO) during immunoprecipitation caused a 150% increase in Goα and a 50% increase in RGS4 in the pellet. When 10 μM GTP was included with DAMGO, there was an additional 72% increase in RGS4 co-immunoprecipitating with MOR (p = 0...
October 2015: Journal of Neurochemistry
https://www.readbyqxmd.com/read/25988317/low-dose-memantine-attenuated-methadone-dose-in-opioid-dependent-patients-a-12-week-double-blind-randomized-controlled-trial
#9
RANDOMIZED CONTROLLED TRIAL
Sheng-Yu Lee, Shiou-Lan Chen, Yun-Hsuan Chang, Po See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Liang-Jen Wang, I Hui Lee, Tzu-Yun Wang, Kao Chin Chen, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band Lu
Low-dose memantine might have anti-inflammatory and neurotrophic effects mechanistically remote from an NMDA receptor. We investigated whether add-on memantine reduced cytokine levels and benefitted patients with opioid dependence undergoing methadone maintenance therapy (MMT) in a randomized, double-blind, controlled 12-week study. Patients were randomly assigned to a group: Memantine (5 mg/day) (n = 53) or Placebo (n = 75). The methadone dose required and retention in treatment were monitored. Plasma tumor necrosis factor (TNF)-α, C-reactive protein (CRP), interleukin (IL)-6, IL-8, transforming growth factor (TGF)-β1, and brain-derived neurotrophic factor (BDNF) levels were examined during weeks 0, 1, 4, 8, and 12...
2015: Scientific Reports
https://www.readbyqxmd.com/read/25837908/practical-considerations-in-opioid-use-for-brain-neoplasm
#10
Michael D Perloff
Neurologists are often on the front lines of diagnosis for primary and metastatic brain tumors. Patients with brain tumors typically have multiple comorbidities and pain generators beyond headache, necessitating opioid therapy. Opioid-based pain relief and safety in the medically ill patient are complex. While using the lowest-potency opioid with adjunct medications is always prudent, patients with brain tumors frequently require dose escalation. Opioid selection and use is based on the patient's respiratory and cardiac function as well as drug clearance capability...
April 2015: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/25716777/a-placebo-controlled-trial-of-dextromethorphan-as-an-adjunct-in-opioid-dependent-patients-undergoing-methadone-maintenance-treatment
#11
RANDOMIZED CONTROLLED TRIAL
Sheng-Yu Lee, Shiou-Lan Chen, Yun-Hsuan Chang, Chun-Hsien Chu, Shih-Heng Chen, Po See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Liang-Jen Wang, I Hui Lee, Tzu-Yun Wang, Kao Chin Chen, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band Lu
BACKGROUND: Low-dose dextromethorphan (DM) might have anti-inflammatory and neurotrophic effects mechanistically remote from an NMDA receptor. In a randomized, double-blind, controlled 12 week study, we investigated whether add-on dextromethorphan reduced cytokine levels and benefitted opioid-dependent patients undergoing methadone maintenance therapy (MMT). METHODS: Patients were randomly assigned to a group: DM60 (60mg/day dextromethorphan; n = 65), DM120 (120mg/day dextromethorphan; n = 65), or placebo (n = 66)...
May 2015: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/25659577/egfrviii-mediated-transactivation-of-receptor-tyrosine-kinases-in-glioma-mechanism-and-therapeutic-implications
#12
S A Greenall, J F Donoghue, M Van Sinderen, V Dubljevic, S Budiman, M Devlin, I Street, T E Adams, T G Johns
A truncation mutant of the epidermal growth factor receptor, EGFRvIII, is commonly expressed in glioma, an incurable brain cancer. EGFRvIII is tumorigenic, in part, through its transactivation of other receptor tyrosine kinases (RTKs). Preventing the effects of this transactivation could form part of an effective therapy for glioma; however, the mechanism by which the transactivation occurs is unknown. Focusing on the RTK MET, we show that MET transactivation in U87MG human glioma cells in vitro is proportional to EGFRvIII activity and involves MET heterodimerization associated with a focal adhesion kinase (FAK) scaffold...
October 8, 2015: Oncogene
https://www.readbyqxmd.com/read/25503939/renin-angiotensin-system-in-pain-existing-in-a-double-life
#13
REVIEW
Anjana Bali, Nirmal Singh, Amteshwar Singh Jaggi
Apart from the well-documented role of the renin-angiotensin-aldosterone system (RAAS) in regulating the blood pressure and other related parameters, its role in modulating different physiological/pathological functions, including pain, has also been described. Like its dual role in regulating stress-related anxiety and cognitive functions, its dual role has also been documented in pain modulation in different disease states. Drugs blocking the RAAS activation, viz., renin inhibitors, angiotensin converting enzyme (ACE) inhibitors, AT(1) receptor antagonists and aldosterone antagonists, have been shown to produce beneficial effects in migraine and neuropathic and nociceptive pain...
December 2014: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/25487930/clinical-application-of-remifentanil-in-local-anesthesia-for-tumor-resection-in-functional-brain-area
#14
RANDOMIZED CONTROLLED TRIAL
S-E Cao, B-Q Gao, Y-Q Zhang, S-M Yang, G-Z Liu, X-R Zhang
OBJECTIVE: The aim of this study was to investigate clinical application of remifentanil in local anesthesia for resection of tumors in functional brain area. PATIENTS AND METHODS: Twenty-four patients were randomly divided into two groups: control group and remifentanil group. In remifentanil group remifentanil was infused intravenously with micro pump in 0.05-0.1 µg·kg-1·min-1. The hemodynamic changes and complications during operation were monitored. RESULTS: The satisfactory degree for surgical procedure was evaluated...
2014: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/25345608/long-term-potentiation-at-spinal-c-fiber-synapses-a-target-for-pathological-pain
#15
REVIEW
Xian-Guo Liu, Li-Jun Zhou
Long-term potentiation (LTP), referring to a lasting increase in efficacy of synaptic transmission, is a common mechanism of memory storage in central nervous system (CNS). LTP at C-fiber synapses in spinal dorsal horn is considered as a synaptic model of pathological pain, as the spinal LTP is only induced by noxious electrical and natural stimuli but not by innoxious ones and LTPinducible stimulation is capable of leading to lasting behavioral signs of pathological pain in human and in animals. The molecular mechanisms of spinal LTP at C-fiber synapses are similar to hippocampal LTP in following aspects...
2015: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/25295639/central-pain
#16
Supreet Singh
Questions from patients about pain conditions and analgesic pharmacotherapy and responses from authors are presented to help educate patients and make them more effective self-advocates. The topic addressed in this issue is central pain, a neuropathic pain syndrome caused by a lesion in the brain or spinal cord that sensitizes one's perception of pain. It is a debilitating condition caused by various diseases such as multiple sclerosis, strokes, spinal cord injuries, or brain tumors. Varied symptoms and the use of pharmacological medicines and nonpharmacological therapies will be addressed...
December 2014: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/24799483/nonopioid-drugs-in-the-treatment-of-cancer-pain
#17
REVIEW
Janette Vardy, Meera Agar
The WHO analgesic ladder for the treatment of cancer pain provides a three-step sequential approach for analgesic administration based on pain severity that has global applicability. Nonopioids were recommended for mild pain, with the addition of mild opioids for moderate pain and strong opioids for severe pain. Here, we review the evidence for the use of nonopioid analgesic agents in patients with cancer and describe the mode of action of the main drug classes. Evidence supports the use of anti-inflammatory drugs such as acetaminophen/paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) for mild cancer pain...
June 1, 2014: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/24751437/palliative-sedation-at-home-for-terminally-ill-children-with-cancer
#18
Aleksandra Korzeniewska-Eksterowicz, Łukasz Przysło, Wojciech Fendler, Małgorzata Stolarska, Wojciech Młynarski
CONTEXT: The presence of symptoms that are difficult to control always requires adjustment of treatment, and palliative sedation (PS) should be considered. OBJECTIVES: We analyzed our experience in conducting PS at home for terminally ill children with cancer during a seven-year period. METHODS: We performed a retrospective analysis of medical records of children with cancer treated at home between the years 2005 and 2011. RESULTS: We analyzed the data of 42 cancer patients (18% of all patients); in 21 cases, PS was initiated (solid tumors n = 11, brain tumors [5], bone tumors [4], leukemia [1])...
November 2014: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/24558758/analysis-of-headache-management-in-emergency-room
#19
Vlasta Vuković Cvetković, Maja Strineka, Marija Knezević-Pavlić, Jasna Tumpić-Jaković, Arijana Lovrencić-Huzjan
The aim of this study was to analyze the management of headache patients presenting to the emergency room (ER) at a university hospital in Zagreb. Retrospective analysis of all patients with headache was carried out during 2007. Patients were analyzed according to the diagnoses, diagnostic procedures, treatment and further referral. Among 6225 patients, 1385 (22.3%) complained of headache; there were 894 (64.5%) women and 491 (35.5%) men. Migraine with or without aura, tension-type headache or "cervicogenic headache" had 1004 (72...
September 2013: Acta Clinica Croatica
https://www.readbyqxmd.com/read/24520393/p-glycoprotein-modulates-morphine-uptake-into-the-cns-a-role-for-the-non-steroidal-anti-inflammatory-drug-diclofenac
#20
Lucy Sanchez-Covarrubias, Lauren M Slosky, Brandon J Thompson, Yifeng Zhang, Mei-Li Laracuente, Kristin M DeMarco, Patrick T Ronaldson, Thomas P Davis
Our laboratory has previously demonstrated that peripheral inflammatory pain (PIP), induced by subcutaneous plantar injection of λ-carrageenan, results in increased expression and activity of the ATP-dependent efflux transporter P-glycoprotein (P-gp) that is endogenously expressed at the blood-brain barrier (BBB). The result of increased P-gp functional expression was a significant reduction in CNS uptake of morphine and, subsequently, reduced morphine analgesic efficacy. A major concern in the treatment of acute pain/inflammation is the potential for drug-drug interactions resulting from P-gp induction by therapeutic agents co-administered with opioids...
2014: PloS One
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