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Esophagogastric cancer

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https://www.readbyqxmd.com/read/28109908/potential-role-of-metronomic-chemotherapy-in-the-treatment-of-esophageal-and-gastroesophageal-cancer
#1
Vanita Noronha, Vijay M Patil, Amit Joshi, Anuradha Chougule, Shripad Banavali, Kumar Prabhash
Patients with esophagogastric cancer have poor prognoses in spite of the best available therapies. Patients are debilitated and may not tolerate, or may progress, on standard cytotoxic chemotherapy regimens. Metronomic chemotherapy is an attractive treatment option due to its very low reported toxicity, modest efficacy, low cost and ease of administration. Capecitabine is the most common drug used in metronomic scheduling; other drugs include cyclophosphamide and paclitaxel. Dosing of capecitabine can range from 1000 mg orally daily for 4 weeks on and 1 week off to a continuous dosing schedule of 1500 mg orally daily...
January 18, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28100248/mediastinal-lymph-node-dissection-and-distal-esophagectomy-is-not-essential-in-early-esophagogastric-junction-adenocarcinoma
#2
In-Seob Lee, Ji-Yong Ahn, Jeong-Hwan Yook, Byung-Sik Kim
BACKGROUND: Optimal extent of surgery remains controversial in types 2 and 3 adenocarcinoma of esophagogastric junction (AEG). We aimed to determine whether the extended procedure including mediastinal lymphadenectomy is essential in all patients with AEG by comparing prognosis and recurrence of proximal gastric adenocarcinoma based on total gastrectomy with intra-abdominal lymphadenectomy. METHODS: The clinicopathologic characteristics of 672 patients (type 2: 90, type 3: 211, upper third of the stomach: 371 cases) who underwent curative total gastrectomy with lymphadenectomy between 2003 and 2009 were reviewed...
January 18, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28008574/use-of-tumor-markers-in-gastrointestinal-cancers-surgeon-perceptions-and-cost-benefit-trade-off-analysis
#3
REVIEW
Amish Acharya, Sheraz R Markar, Michael Matar, Melody Ni, George B Hanna
BACKGROUND: Gastrointestinal cancers constitute the third most common cancers worldwide. Tumor markers have long since been used in the postoperative surveillance of these malignancies; however, the true value in clinical practice remains undetermined. OBJECTIVE: This study aimed to evaluate the clinical utility of three tumor markers in colorectal and esophagogastric cancer. METHODS: A systematic review of the literature was undertaken to elicit the sensitivity, specificity, statistical heterogeneity and ability to predict recurrence and metastases for carcinoembryonic antigen (CEA), cancer antigen (CA) 19-9 and CA125...
December 22, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27999650/subclavian-artery-esophageal-fistula-after-placement-of-a-self-expanding-metal-stent-in-a-patient-with-esophagogastric-anastomosis-stenosis
#4
Mohammadreza Seyedmajidi, Maryam Tavassoli, Mojtaba Kianti, Jamshid Vafaeimanesh
BACKGROUND: There have been reports on stent-related vascular erosions about patients with benign or malignant stenosis of the esophagus who received endoscopic stent insertion for palliative intention for oral intake. CASE PRESENTATION: A 61-year-old woman with esophageal cancer located in the middle part of esophagus was treated with esophagectomy. Two years following the surgery, malignant stenosis recurred in the esophagogastric anastomosis. A non-covered self-expanding metal stent (10 cm length with a diameter of 18 mm at expanded state) was inserted...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27995482/comparison-of-long-term-outcomes-of-endoscopic-submucosal-dissection-and-surgery-for-esophagogastric-junction-adenocarcinoma
#5
Eun Jeong Gong, Do Hoon Kim, Ji Yong Ahn, Kee Wook Jung, Jeong Hoon Lee, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Hee Sung Kim, In-Seob Lee, Beom Su Kim, Moon-Won Yoo, Sung Tae Oh, Jeong Hwan Yook, Byung Sik Kim
BACKGROUND: Endoscopic submucosal dissection (ESD) has become accepted as the standard treatment for early gastric cancer. However, comparative outcomes of ESD and surgery have not been evaluated for adenocarcinoma in the esophagogastric junction (EGJ). We investigated the long-term outcomes of ESD compared with those of surgery for adenocarcinoma in the EGJ. METHODS: Patients who underwent ESD or surgery for Siewert type II adenocarcinoma between 2005 and 2010 and who met the absolute and expanded criteria for endoscopic resection were eligible...
December 19, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27992300/identification-of-the-lymphatic-drainage-pattern-of-esophageal-cancer-with-near-infrared-fluorescent-imaging
#6
Francisco Schlottmann, Arianna Barbetta, Benedetto Mungo, Anne O Lidor, Daniela Molena
OBJECTIVE: Nodal status is one of the most important long-term prognostic factors for esophageal cancer. The aim of this study was to evaluate the ability of near-infrared (NIR) light fluorescent imaging to identify the lymphatic drainage pattern of esophageal cancer. METHODS: Patients with distal esophageal cancer or esophagogastric junction cancer scheduled for esophagectomy were enrolled in this study. Before surgery, an endoscopy was performed with submucosal injection of 2 cc of indocyanine green (ICG) around the tumor...
December 19, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27924395/the-effect-of-postoperative-complications-on-survival-of-patients-after-minimally-invasive-esophagectomy-for-esophageal-cancer
#7
Kun-Kun Li, Yin-Jian Wang, Xue-Hai Liu, Qun-You Tan, Yao-Guang Jiang, Wei Guo
BACKGROUND: Minimally invasive esophagectomy (MIE) has been shown to be a feasible technique for the treatment of esophageal cancer; however, its postoperative morbidity remains high. This retrospective study aimed to evaluate the effect of postoperative complications on long-term outcomes in patients who have undergone MIE for esophageal squamous cell carcinoma (ESCC). METHODS: This retrospective study enrolled patients who had undergone MIE for ESCC between September 2009 and November 2014; all procedures were performed by a single surgical team...
December 6, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27919514/the-psychological-impact-of-symptoms-related-to-esophagogastric-cancer-resection-presenting-in-primary-care-a-national-linked-database-study
#8
G Bouras, S R Markar, E M Burns, J R Huddy, A Bottle, T Athanasiou, A Darzi, G B Hanna
BACKGROUND: The objective was to evaluate incidence, risk factors and impact of postoperative symptoms following esophagogastric cancer resection in primary care. METHODS: Patients undergoing esophagogastrectomy for cancer from 1998 to 2010 with linked records in Clinical Practice Research Datalink, Hospital Episodes Statistics and Office of National Statistics databases were studied. The recording of codes for reflux, dysphagia, dyspepsia, nausea, vomiting, dumping, diarrhea, steatorrhea, appetite loss, weight loss, pain and fatigue were identified up to 12 months postoperatively...
November 9, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27905172/recommendations-for-pathologic-staging-ptnm-of-cancer-of-the-esophagus-and-esophagogastric-junction-for-the-8th-edition-ajcc-uicc-staging-manuals
#9
T W Rice, H Ishwaran, W L Hofstetter, D P Kelsen, C Apperson-Hansen, E H Blackstone
We report analytic and consensus processes that produced recommendations for pathologic stage groups (pTNM) of esophageal and esophagogastric junction cancer for the AJCC/UICC cancer staging manuals, 8th edition. The Worldwide Esophageal Cancer Collaboration provided data for 22,654 patients with epithelial esophageal cancers; 13,300 without preoperative therapy had pathologic assessment after esophagectomy or endoscopic treatment. Risk-adjusted survival for each patient was developed using random survival forest analysis to identify data-driven pathologic stage groups wherein survival decreased monotonically with increasing group, was distinctive between groups, and homogeneous within groups...
November 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27905171/recommendations-for-clinical-staging-ctnm-of-cancer-of-the-esophagus-and-esophagogastric-junction-for-the-8th-edition-ajcc-uicc-staging-manuals
#10
Thomas W Rice, Hemant Ishwaran, Eugene H Blackstone, Wayne L Hofstetter, David P Kelsen, Carolyn Apperson-Hansen
We report analytic and consensus processes that produced recommendations for clinical stage groups (cTNM) of esophageal and esophagogastric junction cancer for the AJCC/UICC cancer staging manuals, 8th edition. The Worldwide Esophageal Cancer Collaboration (WECC) provided data on 22,123 clinically staged patients with epithelial esophageal cancers. Risk-adjusted survival for each patient was developed using random survival forest analysis from which (1) data-driven clinical stage groups were identified wherein survival decreased monotonically and was distinctive between and homogeneous within groups and (2) data-driven anatomic clinical stage groups based only on cTNM...
November 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27905170/recommendations-for-neoadjuvant-pathologic-staging-yptnm-of-cancer-of-the-esophagus-and-esophagogastric-junction-for-the-8th-edition-ajcc-uicc-staging-manuals
#11
Thomas W Rice, Hemant Ishwaran, David P Kelsen, Wayne L Hofstetter, Carolyn Apperson-Hansen, Eugene H Blackstone
We report analytic and consensus processes that produced recommendations for neoadjuvant pathologic stage groups (ypTNM) of esophageal and esophagogastric junction cancer for the AJCC/UICC cancer staging manuals, 8th edition. The Worldwide Esophageal Cancer Collaboration provided data for 22,654 patients with epithelial esophageal cancers; 7,773 had pathologic assessment after neoadjuvant therapy. Risk-adjusted survival for each patient was developed. Random forest analysis identified data-driven neoadjuvant pathologic stage groups wherein survival decreased monotonically with increasing group, was distinctive between groups, and homogeneous within groups...
November 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27904785/overexpression-of-ywhaz-as-an-independent-prognostic-factor-in-adenocarcinoma-of-the-esophago-gastric-junction
#12
Nobuyuki Watanabe, Shuhei Komatsu, Daisuke Ichikawa, Mahito Miyamae, Takuma Ohashi, Wataru Okajima, Toshiyuki Kosuga, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Kazuma Okamoto, Hitoshi Tsuda, Eigo Otsuji
Several studies have demonstrated that YWHAZ (14-3-3ζ), included in the 14-3-3 family of proteins, is implicated in the initiation and progression of cancers. To detect a novel treatment target for adenocarcinoma of the esophagogastric junction (AEG), we tested whether YWHAZ acted as a cancer-promoting gene through its overexpression in AEG. We analyzed YWHAZ protein expression in 92 consecutive primary AEG tumors, which had been curatively resected in our institution between 2000 and 2010. Overexpression of the YWHAZ protein was frequently detected in primary AEG tumor samples (46% (42/92))...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27889780/targeted-treatment-of-esophagogastric-cancer
#13
Hans-Georg Kopp, Ralf-Dieter Hofheinz
Adenocarcinoma of the esophagogastric junction (EGJ) and stomach remains one of the most common causes of cancer-related death worldwide. Although there is increasing data on the mutational landscape of esophagogastric cancer, phase III trials often yield negative results, and there is a paucity of approved targeted agents. For the time being, the subset of patients carrying HER2-positive metastatic tumors can receive trastuzumab in addition to chemotherapy. Furthermore, ramucirumab has been found to be active both as a single agent and in combination with paclitaxel...
2016: Oncology Research and Treatment
https://www.readbyqxmd.com/read/27872128/correction-molecular-heterogeneity-and-receptor-coamplification-drive-resistance-to-targeted-therapy-in-met-amplified-esophagogastric-cancer
#14
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27862622/metabolic-tumor-volume-provides-complementary-prognostic-information-to-eus-staging-in-esophageal-and-junctional-cancer
#15
Vinod Malik, Ciaran Johnston, Dermot O'Toole, Julie Lucey, Naoimh O'Farrell, Zieta Claxton, John V Reynolds
To determine the correlation between (18) F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) derived esophageal tumor parameters [maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV)] and endoscopic ultrasound (EUS) derived tumor parameters (T stage, N stage) and their prognostic implications. 150 consecutive patients with cancer of the esophagus or esophagogastric junction underwent staging PET-CT and staging EUS. PET-CT derived SUVmax and MTV of the primary tumor was recorded...
November 15, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27846123/patient-nursing-and-medical-staff-experiences-and-perceptions-of-the-care-of-people-with-palliative-esophagogastric-cancer-a-systematic-review-of-the-qualitative-evidence
#16
Alison Cowley, Catrin Evans, Fiona Bath-Hextall, Joanne Cooper
BACKGROUND: Esophagogastric cancer is the fifth most common malignancy and its incidence is increasing. The disease progresses quickly and five-year survival rates are poor. Treatment with palliative intent is provided for the majority of patients but there remains a lack of empirical evidence on the most effective service models to support esophagogastric cancer patients. OBJECTIVES: The overall objective of this systematic review was to synthesize the best available evidence on the experiences and perceptions of patients and health professionals with regard to the care of people diagnosed with palliative esophagogastric cancer...
October 2016: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/27810391/cancer-of-the-esophagus-and-esophagogastric-junction-an-eighth-edition-staging-primer
#17
Thomas W Rice, Hemant Ishwaran, Mark K Ferguson, Eugene H Blackstone, Peter Goldstraw
This primer for eighth edition staging of esophageal and esophagogastric epithelial cancers presents separate classifications for the clinical (cTNM), pathologic (pTNM), and postneoadjuvant pathologic (ypTNM) stage groups, which are no longer shared. For pTNM, pT1 has been subcategorized as pT1a and pT1b for the subgrouping pStage I adenocarcinoma and squamous cell carcinoma. A new, simplified esophagus-specific regional lymph node map has been introduced. Undifferentiated histologic grade (G4) has been eliminated; additional analysis is required to expose histopathologic cell type...
January 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27809860/preoperative-pre-albumin-predicts-prognosis-of-patients-after-gastrectomy-for-adenocarcinoma-of-esophagogastric-junction
#18
Wen-Xiu Han, Zhang-Ming Chen, Zhi-Jian Wei, A-Man Xu
BACKGROUND: Adenocarcinoma of esophagogastric junction (AEG) was initially proposed in 1999 by Siewert. During recent decades, the incidence and prevalence of AEG were arising globally whereas the incidence of gastric cancer is gradually declining. Complete blood counting and liver function tests, as the routine examination of immune and nutritional status, were reported to be the predictors of overall survival (OS) in some tumors. However, little is known about the prognostic significance of these indexes in AEG patients...
November 3, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27796514/results-of-a-nation-wide-retrospective-study-of-lymphadenectomy-for-esophagogastric-junction-carcinoma
#19
Hiroharu Yamashita, Yasuyuki Seto, Takeshi Sano, Hiroyasu Makuuchi, Nobutoshi Ando, Mitsuru Sasako
BACKGROUND: Esophagogastric junction (EGJ) carcinoma has attracted considerable attention because of the marked increase in its incidence globally. However, the optimal extent of esophagogastric resection for this tumor entity remains highly controversial. METHODS: This was a questionnaire-based national retrospective study undertaken in an attempt to define the optimal extent of lymph node dissection for EGJ cancer. Data from patients with EGJ carcinoma, less than 40 mm in diameter, who underwent R0 resection between January 2001 and December 2010 were reviewed...
October 28, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27783358/robotic-assisted-minimally-invasive-esophagectomy-for-treatment-of-esophageal-carcinoma
#20
Philip W Chiu, Anthony Y Teoh, Vivien W Wong, Hon Chi Yip, Shannon M Chan, Simon K Wong, Enders K Ng
Minimally invasive esophagectomy (MIE) is technically challenging. Da Vinci Robotic system could improve surgical dissection with additional degree of freedom from robotic arms. This study aimed to assess the feasibility and safety of performing MIE using Da Vinci Robotic system among patients with esophageal cancers. From 2009 to 2013, consecutive patients with esophageal cancers who received robotic-assisted MIE were recruited. We excluded tumors with suspected invasion to adjacent organs. Preoperative staging included EUS, CT thorax and abdomen and bronchoscopy...
October 25, 2016: Journal of Robotic Surgery
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