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Resveratrol and cancer

Lucrecia Carrera-Quintanar, Rocío I López Roa, Saray Quintero-Fabián, Marina A Sánchez-Sánchez, Barbara Vizmanos, Daniel Ortuño-Sahagún
Gut microbiota (GM) plays several crucial roles in host physiology and influences several relevant functions. In more than one respect, it can be said that you "feed your microbiota and are fed by it." GM diversity is affected by diet and influences metabolic and immune functions of the host's physiology. Consequently, an imbalance of GM, or dysbiosis, may be the cause or at least may lead to the progression of various pathologies such as infectious diseases, gastrointestinal cancers, inflammatory bowel disease, and even obesity and diabetes...
2018: Mediators of Inflammation
Liang Cheng, Bin Yan, Ke Chen, Zhengdong Jiang, Cancan Zhou, Junyu Cao, Weikun Qian, Jie Li, Liankang Sun, Jiguang Ma, Qingyong Ma, Huanchen Sha
NAF-1 (nutrient-deprivation autophagy factor-1), which is an outer mitochondrial membrane protein, is known to play important roles in calcium metabolism, antiapoptosis, and antiautophagy. Resveratrol, a natural polyphenolic compound, is considered as a potent anticancer agent. Nevertheless, the molecular mechanisms underlying the effects of resveratrol and NAF-1 and their mediation of drug resistance in pancreatic cancer remain unclear. Here, we demonstrate that resveratrol suppresses the expression of NAF-1 in pancreatic cancer cells by inducing cellular reactive oxygen species (ROS) accumulation and activating Nrf2 signaling...
2018: Oxidative Medicine and Cellular Longevity
Leda Roncoroni, Luca Elli, Paola Braidotti, Delfina Tosi, Valentina Vaira, Lorenza Tacchini, Vincenza Lombardo, Federica Branchi, Alice Scricciolo, Luisa Doneda
Resveratrol is a polyphenolic compound extracted from plants and is also a constituent of red wine. Our aim was to evaluate if the cytotoxic effect of resveratrol (RES) on cholangiocarcinoma (CC) and gallbladder cancer (GBC) cell lines could be abolished by TG2 inhibition. Human CC and GBC cell lines (SK-ChA-1 and MZ-ChA-1), grown in a three-dimensional cell culture system (MCTS, multicellular tumor spheroids), were treated for 72 h with RES (32, 64 µM) alone or combined with different TG2 inhibitors (Cystamine, B003, T101)...
May 14, 2018: Nutrition and Cancer
Foo Kit Cheah, Kok Hoong Leong, Noel Francis Thomas, Hui Kee Chin, Azhar Ariffin, Khalijah Awang
Resveratrol, a naturally occurring polyphenolic antioxidant, is a potential chemoprophylactic agent for various cancers, including colorectal cancer. Although emerging evidence continually suggests that a number of resveratrol derivatives may be better cancer chemopreventive candidates than resveratrol, studies on the mechanism of action of these derivatives are limited. This is the first study which investigates the mechanism underlying the cytotoxic effect of a synthesized resveratrol analogue, (E)-N-(2-(4-methoxystyryl) phenyl) furan-2-carboxamide (CS) on colorectal cancer...
May 12, 2018: Apoptosis: An International Journal on Programmed Cell Death
Allison Knickle, Wasundara Fernando, Anna L Greenshields, H P Vasantha Rupasinghe, David W Hoskin
Myricetin is a dietary phytochemical with anticancer activity; however, the effect of myricetin on breast cancer cells remains unclear. Here, we show that myricetin inhibited the growth of triple-negative breast cancer (TNBC) cells but was less inhibitory for normal cells. The effect of myricetin was comparable to epigallocatechin gallate and doxorubicin, and greater than resveratrol and cisplatin. Myricetin-treated TNBC cells showed evidence of early and late apoptosis/necrosis, which was associated with intracellular reactive oxygen species (ROS) accumulation, extracellular regulated kinase 1/2 and p38 mitogen-activated protein kinase activation, mitochondrial membrane destabilization and cytochrome c release, and double-strand DNA breaks...
May 6, 2018: Food and Chemical Toxicology
Hong-Guang Jin, Guo-Zhen Wu, Guo-Hua Wu, Yong-Ge Bao
Rapamycin is known to inhibit the mammalian target of rapamycin complex (mTORC)1 signaling pathway, but it is unable to effectively inhibit mTORC2, resulting in activation of protein kinase B in multiple myeloma (MM) cell lines. Additionally, certain studies have suggested that resveratrol has an effect on human MM cells, and that rapamycin in combination with resveratrol may be useful in cancer therapy. The present study aimed to investigate the combined treatment effect of resveratrol and rapamycin on the MM MM1...
May 2018: Oncology Letters
Şule Ayla, Ayhan Bilir, Şenol Ertürkoğlu, Gamze Tanrıverdi, B. Cem Soner, Kenan Sofuoğlu, Laura Ghisolfi, Gülperi Öktem
Background/aim: In this study, the effects of resveratrol as a natural polyphenol compound, gemcitabine as an antimetabolite that has nucleoside structure analogous to deoxycytidine, and para-aminophenol-derived paracetamol were investigated with single and combined applications in monolayers of the MDAH-2774 human ovarian cancer cell line. Materials and methods: Drugs were evaluated in cell culture with respect to cell proliferation, cell cytotoxicity (trypan blue dye exclusion test), synthesis phase of cell cycle, and cell structure in 24, 48, 72, and 96 h...
April 30, 2018: Turkish Journal of Medical Sciences
Ying Xin, Haiyan Zhang, Zhaotong Jia, Xiaoqian Ding, Yong Sun, Qiang Wang, Tao Xu
Resveratrol (RSV) has been reported to exert anti-inflammatory, anti-oxidant and anti-cancer effects both in vivo and in vitro, and is widely used to treat various diseases. However, the effect of RSV on type 2 diabetes (T2D) is still unclear. The present study aimed to explore the effect of RSV on UA-induced cell injury and dysfunction in pancreatic β-cells. The mouse insulinoma cell line Min6 was treated with 5 mg/dl UA and different concentrations of RSV. Then, cell viability, apoptosis, apoptosis-associated factors, iNOS expression and insulin secretion were examined by CCK-8, flow cytometry, western blot, qRT-PCR and glucose-stimulated insulin secretion (GSIS), respectively...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Tingting Yang, Jianmei Zhang, Junting Zhou, Meixiao Zhu, Li Wang, Lianhe Yan
Previous studies show that migration and invasion are the primary causes of death in patients with gastric carcinoma. Increasing evidences have been shown Interleukin-6 could stimulate cancer cells invasion and be associated with cancer development. However, its role in gastric cancer has never been investigated. As an anticancer drug isolated from Chinese medicine, resveratrol was reported to inhibit cancer cells growth and induce apoptosis, but its roles in gastric cancer have not been well understood. In this study, we found that Interleukin-6 was upregulated in blood of gastric cancer patients by enzyme-linked immunosorbent assay...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Pegah Mirzapur, Mohammad Rasool Khazaei, Mohammad Taher Moradi, Mozafar Khazaei
AIMS: Breast cancer is the most common cancer of women. The aim of this study was to investigate the synergic effect of raloxifene (Ral) and resveratrol (Res) on apoptosis of breast cancer cell lines (MCF7 and MDA-MB-231). MAIN METHODS: Cells were treated with Ral and Res alone and in combination. Cell viability (MTT assay), apoptosis (TUNEL assay) and nitric oxide (NO) production (Griess method) were investigated. Expression of proapoptotic gene (Bax and p53), anti-apoptotic gene (Bcl2) and caspases-3, caspase -8 were evaluated...
April 26, 2018: Life Sciences
Kenichi Yamada, Yuuki Hiradate, Mei Goto, Chiho Nishiyama, Kenshiro Hara, Hiroaki Yoshida, Kentaro Tanemura
Purpose: As disturbed mitochondrial distribution is thought to be a cause of the aging of oocytes, it was investigated whether oxidizing agents exert harmful effects on nuclear maturation and mitochondrial cluster formation in murine oocytes and whether antioxidants could rescue such harmful effects in vitro. Methods: Oocytes were obtained from female Institute of Cancer Research mice 48 h after an intraperitoneal injection of 7.5 IU pregnant mare serum gonadotropin...
April 2018: Reproductive Medicine and Biology
Laetitia Nivelle, Virginie Aires, Damien Rioult, Laurent Martiny, Michel Tarpin, Dominique Delmas
Very recently, we have produced new resveratrol derived compounds, especially labruscol by culture of elicited grapevine cell suspensions (Vitis labrusca L.). This new polyphenolic oligomer could function as cancer chemopreventive agent in similar manner of resveratrol. In this study, we have determined the efficiency of resveratrol, ε-viniferin and the labruscol on human melanoma cell with or without metastatic phenotype. Our results show a differential activity of the three compounds where the resveratrol remains the polyphenolic compound with the most effective action compared to other oligomers...
April 20, 2018: Food and Chemical Toxicology
Graciela Ruíz, Heriberto A Valencia-González, Ismael León-Galicia, Enrique García-Villa, Alejandro García-Carrancá, Patricio Gariglio
Cervical cancer is the second most frequent tumor type in women worldwide with cases developing clinical recurrence, metastasis, and chemoresistance. The cancer stem cells (CSC) may be implicated in tumor resistance to therapy. RESveratrol (RES), a natural compound, is an antioxidant with multiple beneficial activities. We previously determined that the expression of RAD51 is decreased by RES. The aim of our study was to examine molecular mechanism by which CSC from HeLa cultures exhibit chemoresistance. We hypothesized CSC repair more efficiently DNA breaks and that RAD51 plays an important role in this mechanism...
2018: Stem Cells International
Santosh Kumar Singh, James W Lillard, Rajesh Singh
The folate receptor (FR) is a valued target that is highly expressed in various cancers, which will expedite the development of ligand-receptor binding based cancer therapeutics. In the present investigation, through tissue microarray analysis, we report higher levels of folate receptor expression in prostate cancer (PCa) tissue derived from patients, which were minimal in normal tissue. For folate-receptor based targeted therapy of PCa, we generated novel planetary ball milled (PBM) nanoparticles (NPs) encapsulated with resveratrol (RES), and in combination with docetaxel (DTX) and conjugated with folic acid (FA) on the surface...
April 17, 2018: Cancer Letters
Gbotolorun Stella Chinwe, Okafor Izuchukwu Azuka, Ndoeche Chidinma Adaeze
Background: Cisplatin is a potent antineoplastic agent for many cancers but causes several levels of gonadal damage. Ovarian toxicity is a major concern of young cancer patients undergoing chemotherapy. Objective: This study sought to examine the effect of Cisplatin and Resveratrol supplementation on ovarian function in Sprague-Dawley rats. Materials and Methods: In this experimental study, 45 cyclic Sprague-Dawley rats with an average weight of 160 gr were divided into 9 groups (n=5/group)...
January 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Pravat Kumar Parida, Barun Mahata, Abhisek Santra, Sohini Chakraborty, Zhumur Ghosh, Sanghamitra Raha, Anup Kumar Misra, Kaushik Biswas, Kuladip Jana
Resveratrol, a trans-stilbene polyphenolic compound and its synthetic analogs are widely used bioactive molecules due to their remarkable chemo-preventive potential. Here, we have identified a novel synthetic trans-stilbene compound, Z-DAN-11 ((Z)-3-(3, 4-dimethoxyphenyl)-2-(3, 4, 5-trimethoxyphenyl) acrylonitrile) which shows remarkable efficacy in blocking tumor growth and progression both in vitro and in vivo. Z-DAN-11 inhibits proliferation of cancer cells in vitro through microtubule depolymerization that induced G2/M arrest and consequently leads to apoptotic cell death...
April 18, 2018: Cell Death & Disease
Yu Liu, Lin Tong, Yan Luo, Xin Li, Gaowen Chen, Yifeng Wang
Aerobic glycolysis is an important metabolic rewiring in cancer cells to promote glucose uptake and lactate production, and targeting aerobic glycolysis becomes a promising therapeutic approach for cancer. Here we reported that a small polyphenol resveratrol exhibited profound anti-tumor efficacy on human ovarian cancer. Resveratrol markedly inhibited the proliferation, migration, and invasion of A2780 and SKOV3 ovarian cancer cells, while impaired glycolysis, and induced apoptosis in these cells. Exposure to resveratrol increased the expression and activation of AMPK and Caspase 3, and decreased the expression and activation of AMPK downstream kinase mTOR...
April 16, 2018: Journal of Cellular Biochemistry
Taghi Khanzadeh, Majid Farshdousti Hagh, Mehdi Talebi, Bahman Yousefi, Ako Azimi, Abbas Ali Hossein Pour Feizi, Behzad Baradaran
Background: The numerous side effects and chemo-resistance of conventional chemical drugs in the treatment of malignancies have led to consideration of the anti-cancer properties of natural products. In the present study, we aimed to explore the apoptotic effect of two natural components, resveratrol and prednisolone, on the T acute lymphoblastic leukemia (ALL) cell line, CCRF-CEM. Our findings suggested the incorporation of these natural agents into drug regimens to treat patients with ALL...
March 2018: Blood Research
I Leon-Galicia, J Diaz-Chavez, M E Albino-Sanchez, E Garcia-Villa, R Bermudez-Cruz, J Garcia-Mena, L A Herrera, A García-Carrancá, P Gariglio
Resveratrol (RES), a polyphenol compound with anti‑proliferative properties, has been previously evaluated for its beneficial effects against a variety of tumour cells. The current study elucidated the means by which RES enhances the anti‑proliferative effects of cisplatin (CIS) on MCF‑7 cells, focusing on the inhibitory effects on DNA repair of double‑strand breaks (DSBs). Chemoresistant MCF‑7 cells (MCF‑7R) were generated by continuous exposure to low concentrations of CIS (10 µM CIS‑IC40) during 5 passages, with the IC50 value increasing ~3‑fold...
March 27, 2018: Oncology Reports
Marco Malavolta, Massimo Bracci, Lory Santarelli, Md Abu Sayeed, Elisa Pierpaoli, Robertina Giacconi, Laura Costarelli, Francesco Piacenza, Andrea Basso, Maurizio Cardelli, Mauro Provinciali
The reactivation of senescence in cancer and the subsequent clearance of senescent cells are suggested as therapeutic intervention in the eradication of cancer. Several natural compounds that activate Nrf2 (nuclear factor erythroid-derived 2-related factor 2) pathway, which is involved in complex cytoprotective responses, have been paradoxically shown to induce cell death or senescence in cancer. Promoting the cytoprotective Nrf2 pathway may be desirable for chemoprevention, but it might be detrimental in later stages and advanced cancers...
2018: Mediators of Inflammation
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