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Resveratrol and cancer

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https://www.readbyqxmd.com/read/27912881/anti-metastatic-potential-of-resveratrol-and-its-metabolites-by-the-inhibition-of-epithelial-mesenchymal-transition-migration-and-invasion-of-malignant-cancer-cells
#1
REVIEW
Cho-Won Kim, Kyung-A Hwang, Kyung-Chul Choi
BACKGROUND: Increased epithelial-mesenchymal transition (EMT) and cell migration and invasion abilities of cancer cells play important roles in the metastatic process of cancer. Resveratrol is a stilbenoid, a type of natural polyphenol found in the skin of grapes, berries, and peanuts. A number of experiments have examined resveratrol's ability to target diverse pathways associated with carcinogenesis and cancer progression. PURPOSE: This article aims to present updated overview of the knowledge that resveratrol and its metabolites or analogs have the potential to inhibit metastasis of cancer via affecting many signaling pathways related with EMT, cancer migration, and invasion in diverse organs of the body...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27912878/selecting-optimum-protein-nano-carriers-for-natural-polyphenols-using-chemoinformatics-tools
#2
AbdelKader A Metwally, Sherweit H El-Ahmady, Rania M Hathout
BACKGROUND: The normal fate of any natural product with a therapeutic potential is to be formulated into an effective medicine. However, the conventional methods of selecting the suitable formulations or carriers based on the formulator experiences, trials and errors as well as materials availability do not usually yield the optimal results. HYPOTHESIS: We hypothesize the possibility of the virtual optimum selection of a protein carrier for two polyphenolic compounds widely investigated for their chemopreventive effects; resveratrol and curcumin using a combination of some chemoinformatics tools...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27906095/resveratrol-and-acetyl-resveratrol-modulate-activity-of-vegf-and-il-8-in-ovarian-cancer-cell-aggregates-via-attenuation-of-the-nf-%C3%AE%C2%BAb-protein
#3
Alexandria B Tino, Kenny Chitcholtan, Peter H Sykes, Ashley Garrill
BACKGROUND: Key features of advanced ovarian cancer include metastasis via cell clusters in the abdominal cavity and increased chemoresistance. Resveratrol and derivatives of resveratrol have been shown to have antitumour properties. The purpose of this study was to investigate the effect of resveratrol and acetyl-resveratrol on 3D cell aggregates of ovarian cancer, and establish if NF-κB signalling may be a potential target. METHODS: Poly-HEMA coated wells were used to produce 3D aggregates of two ovarian cancer cell lines, SKOV-3 and OVCAR-5...
December 1, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27888721/discovery-of-resveratrol-derivatives-as-novel-lsd1-inhibitors-design-synthesis-and-their-biological-evaluation
#4
Ying-Chao Duan, Yuan-Yuan Guan, Xiao-Yu Zhai, Li-Na Ding, Wen-Ping Qin, Dan-Dan Shen, Xue-Qi Liu, Xu-Dong Sun, Yi-Chao Zheng, Hong-Min Liu
Inhibition of lysine-specific demethylase 1 (LSD1) has recently emerged as an attractive therapeutic target for treating cancer and other diseases. As a continuity of our ongoing effort to identify novel small-molecule LSD1-inhibitors, we designed and synthesized a series of resveratrol derivatives, which were shown to be potent inhibitors of LSD1. Among them, compounds 4e and 4m displayed the most potent LSD1-inhibitory activities in enzyme assays, with IC50 values of 121 nM and 123 nM, respectively. Biochemistry study and docking analysis indicated that compounds 4e and 4m were reversible LSD1 inhibitors...
November 16, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27880855/the-paradoxical-pro-and-antiangiogenic-actions-of-resveratrol-therapeutic-applications-in-cancer-and-diabetes
#5
Mohammad Amin Kamaleddin
Resveratrol, a polyphenol found in grapes, peanuts, and red wine, plays different roles in diseases such as cancer and diabetes. Existing information indicates that resveratrol provides cardioprotection, as evidenced by superior postischemic ventricular recovery, reduced myocardial infarct size, and decreased number of apoptotic cardiomyocytes associated with resveratrol treatment in animal models. Cardiovascular benefits are experienced in humans with routine but not acute consumption of red wine. In this concise review, the paradoxical pro- and antiangiogenic effects of resveratrol are described, and different roles for resveratrol in the formation of new blood vessels are explained through different mechanisms...
November 23, 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27869173/pterostilbene-induces-apoptosis-and-cell-cycle-arrest-in-diffuse-large-b-cell-lymphoma-cells
#6
Yuanyuan Kong, Gege Chen, Zhijian Xu, Guang Yang, Bo Li, Xiaosong Wu, Wenqin Xiao, Bingqian Xie, Liangning Hu, Xi Sun, Gaomei Chang, Minjie Gao, Lu Gao, Bojie Dai, Yi Tao, Weiliang Zhu, Jumei Shi
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL). Pterostilbene, a natural dimethylated analog of resveratrol, has been shown to possess diverse pharmacological activities, including anti-inflammatory, antioxidant and anticancer properties. However, to the best of our knowledge, there has been no study of the effects of pterostilbene upon hematological malignancies. Herein, we report the antitumor activity and mechanism of pterostilbene against DLBCL cells both in vitro and in vivo...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27865863/curcumin-promotes-the-oncoltyic-capacity-of-vesicular-stomatitis-virus-for-the-treatment-of-prostate-cancers
#7
Dylan J Fehl, Maryam Ahmed
Vesicular stomatitis virus (VSV) matrix (M) protein mutants have been studied as oncolytic agents due to their capacity to effectively kill cancer cells while exhibiting low virulence in vivo. Despite encouraging results, many cancer cells maintain resistance to oncolytic VSV mutants in part due to residual antiviral responses. We sought to determine whether combination of VSV with natural agents with anti-tumor properties, such as curcumin, resveratrol, and flavokavain B, would enhance tumor cell killing in a prostate cancer model...
November 16, 2016: Virus Research
https://www.readbyqxmd.com/read/27865301/resveratrol-inhibited-non-small-cell-lung-cancer-through-inhibiting-stat-3-signaling
#8
Xin Li, Dan Wang, Qing Chun Zhao, Tao Shi, Jun Chen
BACKGROUND: Resveratrol has demonstrated many beneficial effects against cancers; however, the mechanism remains unclear. Non-small cell lung cancer accounts for 80% of lung cancers. The present study was designed to observe the effects and related mechanisms of resveratrol on non-small cell lung cancer in in vitro A549 cells. MATERIALS AND METHODS: The anticancer effects of resveratrol were analyzed on cell viability, migration and invasion, proliferation and apoptosis...
November 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27863838/resveratrol-enhances-the-efficacy-of-sorafenib-mediated-apoptosis-in-human-breast-cancer-mcf7-cells-through-ros-cell-cycle-inhibition-caspase-3-and-parp-cleavage
#9
Arindam Mondal, Lunawati L Bennett
Despite advances in diagnosis and treatment options, breast cancer is one of the main causes of cancer related death among women worldwide. Present study is aimed to preliminarily evaluate our hypothesis that the combination of resveratrol (RSV), a natural antioxidant, and lower dose of sorafenib (SF), a multi-kinase inhibitor and a component of ERK1/2 (extracellular signal-regulated kinase 1/2) pathway, would augment apoptosis in human breast cancer MCF7 cells. MCF7 cellexpressions s were treated with RSV, SF and their combination...
November 15, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27853366/development-of-plga-lipid-nanoparticles-with-covalently-conjugated-indocyanine-green-as-a-versatile-nanoplatform-for-tumor-targeted-imaging-and-drug-delivery
#10
Yu Xin, Tie Liu, Chenlong Yang
We have prepared novel poly(d,l-lactide-co-glycolide) (PLGA) lipid nanoparticles (PNPs) that covalently conjugate folic acid (FA) and indocyanine green (ICG), in addition to encapsulating resveratrol (RSV) (FA-RSV/ICG-PLGA-lipid NPs, abbreviated as FA-RIPNPs); these nanoparticles have been developed for simultaneous targeted delivery of anticancer drug and fluorescence imaging. The FA-RIPNPs, with an average particle size of 92.8±2.1 nm, were prepared by a facile self-assembly-and-nanoprecipitation method, and they showed excellent stability and biocompatibility characteristics...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27834913/unraveling-the-anticancer-effect-of-curcumin-and-resveratrol
#11
REVIEW
Aline Renata Pavan, Gabriel Dalio Bernardes da Silva, Daniela Hartmann Jornada, Diego Eidy Chiba, Guilherme Felipe Dos Santos Fernandes, Chung Man Chin, Jean Leandro Dos Santos
Resveratrol and curcumin are natural products with important therapeutic properties useful to treat several human diseases, including cancer. In the last years, the number of studies describing the effect of both polyphenols against cancer has increased; however, the mechanism of action in all of those cases is not completely comprehended. The unspecific effect and the ability to interfere in assays by both polyphenols make this challenge even more difficult. Herein, we analyzed the anticancer activity of resveratrol and curcumin reported in the literature in the last 11 years, in order to unravel the molecular mechanism of action of both compounds...
November 10, 2016: Nutrients
https://www.readbyqxmd.com/read/27834615/development-and-characterization-of-resveratrol-nanoemulsions-carrying-dual-imaging-agents
#12
Michele Herneisey, Jonathan Williams, Janja Mirtic, Lu Liu, Sneha Potdar, Christina Bagia, Jane E Cavanaugh, Jelena M Janjic
AIM: Delivery of the natural anti-inflammatory compound resveratrol with nanoemulsions can dramatically improve its tissue targeting, bioavailability and efficacy. Current assessment of resveratrol delivery efficacy is limited to indirect pharmacological measures. Molecular imaging solves this problem. Results/methodology: Nanoemulsions containing two complementary imaging agents, near-infrared dye and perfluoropolyether (PFPE), were developed and evaluated. Nanoemulsion effects on macrophage uptake, toxicity and NO production were also evaluated...
November 11, 2016: Therapeutic Delivery
https://www.readbyqxmd.com/read/27829129/resveratrol-inhibits-hexokinases-ii-mediated-glycolysis-in-non-small-cell-lung-cancer-via-targeting-akt-signaling-pathway
#13
Wei Li, Xiaoqian Ma, Na Li, Huasheng Liu, Qiong Dong, Juan Zhang, Cejun Yang, Yin Liu, Qi Liang, Shengwang Zhang, Chang Xu, Wei Song, Shiming Tan, Pengfei Rong, Wei Wang
Deregulation of glycolysis was often observed in human cancer cells. In the present study, we reported resveratrol, a small polyphenol, which has been intensively studied in various tumor models, has a profound anti-tumor effect on human non-small cell lung cancer (NSCLC) via regulation of glycolysis. Resveratrol impaired hexokinase II (HK2)-mediated glycolysis, and markedly inhibited anchorage-dependent and -independent growth of NSCLC cells. Exposure to resveratrol decreased EGFR and downstream kinases Akt and ERK1/2 activation...
November 6, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27826066/plant-polyphenols-as-natural-drugs-for-the-management-of-down-syndrome-and-related-disorders
#14
REVIEW
Rosa Anna Vacca, Daniela Valenti, Salvatore Caccamese, Maria Daglia, Nady Braidy, Seyed Mohammad Nabavi
Polyphenols are secondary metabolites of plants largely found in fruits, vegetables, cereals and beverages, and therefore represent important constituents of the human diet. Increasing studies have demonstrated the potential beneficial effects of polyphenols on human health. Extensive reviews have discussed the protective effects of polyphenols against a series of diseases such as cancer, cardiovascular diseases, diabetes, and neurodegenerative disorders. Limited studies have investigated the potential therapeutic effects of these natural compounds on neurodevelopmental disorders associated with intellectual disability, such as Down syndrome (DS), for which mitochondrial dysfunctions and oxidative stress are hallmarks and contribute to the deleterious symptoms and cognitive decline...
November 5, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27825563/resveratrol-inhibits-lung-cancer-growth-by-suppressing-m2-like-polarization-of-tumor-associated-macrophages
#15
Liwei Sun, Bonian Chen, Rong Jiang, Jinduo Li, Bin Wang
In cancer, tumor associated macrophages (TAMs) play an important role in the cancer progression, evasion of immunity and dissemination of cancer cells. Inhibition of the activation or the M2 polarization of TAMs is an effective therapy for cancer. In the present study, we investigated the ability of resveratrol (RES) to inhibit lung cancer growth using in vitro and in vivo studies, and examined the underlying mechanisms. We demonstrated that M2 polarization of human monocyte derived macrophage (HMDMs) induced by the lung cancer cells conditioned medium was inhibited by RES...
November 2, 2016: Cellular Immunology
https://www.readbyqxmd.com/read/27809606/design-synthesis-and-antibreast-cancer-mcf-7-cells-biological-evaluation-of-heterocyclic-analogs-of-resveratrol
#16
Cheng Du, Ming-Hui Dong, Yu-Jie Ren, Lu Jin, Cheng Xu
A new series of resveratrol heterocyclic analogs (4a-m) were designed and synthesized, and their inhibitiory effects on MCF-7 cells were evaluated to investigate structure-activity relationship. The effects of these analogs on human breast cancer MCF-7 cells were also determined. Results showed that MCF-7 cells could be inhibited more potently by these analogs than by resveratrol (IC50 = 80.0 μM). Among the analogs, compounds 4c, 4e, and 4k showed a significantly higher activity (IC50 = 42.7, 48.1, and 43...
November 3, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27806317/resveratrol-changes-spermatogonial-stem-cells-sscs-activity-and-ameliorates-their-loss-in-busulfan-induced-infertile-mouse
#17
Chongyang Wu, Ying Zhang, Qiaoyan Shen, Zhe Zhou, Weishuai Liu, Jinlian Hua
The decline of quantity and quality of sperm are correlated with the increasing age and some anti-cancer compounds such as busulfan. Previous studies have shown that Resveratrol (Res) inhibits tumorigenesis and metastasis of many cancers including mammary tumor, prostate and pancreatic cancers. It acts as anti-age in mouse and human, however, little is known about its protective effect on aged spermatogonial stem cells (SSCs). Here, we investigated the effects of Res in vitro on SSCs usingC18-4 cells and in vivo in busulfan-induced azoospermia mice model...
October 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27788010/resveratrol-interaction-with-lipid-bilayers-a-synchrotron-x-ray-scattering-study
#18
Ana Rute Neves, Cláudia Nunes, Heinz Amenitsch, Salette Reis
Resveratrol belongs to the large group of biologically active polyphenol compounds with several health beneficial effects including anti-oxidant activity, anti-inflammatory action, cardiovascular protection, neuroprotection and cancer chemoprevention. In the present study it is raised the possibility that the effects of resveratrol described above are caused by resveratrol membrane interactions and structural modifications of lipid bilayers. In this context, it is possible that resveratrol interacts selectively with lipid domains present in biological membranes, thereby modulating the localization of the anchored proteins and controlling their intracellular cascades...
October 27, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27787915/resveratrol-inhibits-il-6-induced-ovarian-cancer-cell-migration-through-epigenetic-up-regulation-of-autophagy
#19
Alessandra Ferraresi, Suratchanee Phadngam, Federica Morani, Alessandra Galetto, Oscar Alabiso, Giovanna Chiorino, Ciro Isidoro
Interleukin-6 (IL-6), a pro-inflammatory cytokine released by cancer associated fibroblasts, has been linked to the invasive and metastatic behavior of ovarian cancer cells. Resveratrol is a naturally occurring polyphenol with the potential to inhibit cancer cell migration. Here we show that Resveratrol and IL-6 affect in an opposite manner the expression of RNA messengers and of microRNAs involved in cell locomotion and extracellular matrix remodeling associated with the invasive properties of ovarian cancer cells...
October 27, 2016: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27783972/discovery-of-oral-available-resveratrol-caffeic-acid-based-hybrids-inhibiting-acetylated-and-phosphorylated-stat3-protein
#20
Shanshan Li, Wenda Zhang, Yanwei Yang, Ting Ma, Jianpeng Guo, Shanshan Wang, Wenying Yu, Lingyi Kong
Constitutive activation of STAT3 has been found in a wide variety of cancers and demonstrated as a very attractive therapeutic target. Disrupting both acetylation and phosphorylation of STAT3 protein was hypothesized to greatly deactivate STAT3, therefore, treating cancers. To demonstrate the hypothesis, two series of novel resveratrol-caffeic acid hybrids were designed aiming to regulate both acetylation and phosphorylation of STAT3 protein, which is also the first report of the synthetic inhibitors simultaneously regulating two biological reactions of STAT3 to our knowledge...
October 15, 2016: European Journal of Medicinal Chemistry
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