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Hepatitis, liver, cirrhosis, elastography, fibrosis

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https://www.readbyqxmd.com/read/29922758/100-sustained-virological-response-and-fibrosis-improvement-in-real-life-use-of-direct-acting-antivirals-in-genotype-1b-recurrent-hepatitis-c-following-liver-transplantation
#1
Speranta Iacob, Razvan Cerban, Corina Pietrareanu, Carmen Ester, Razvan Iacob, Cristian Gheorghe, Irinel Popescu, Liana Gheorghe
BACKGROUND: Nowadays, interferon-free therapy using new direct-acting antivirals (DAA) has dramatically increased the cure rate across different HCV-infected patient populations, including groups traditionally viewed as difficult-to-treat (patients with co-infections, cirrhosis and liver transplant - LT recipients) with marked improvement in safety and tolerability. AIM: To present our experience with DAA therapy in LT recipients, as well as to compare pre- and post-treatment liver stiffness (LS) and noninvasive fibrosis scores...
June 2018: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/29902644/high-prevalence-of-hepatic-fibrosis-measured-by-elastography-in-a-population-based-study-of-mexican-americans
#2
Gordon P Watt, Miryoung Lee, Jen-Jung Pan, Michael B Fallon, Rohit Loomba, Laura Beretta, Joseph B McCormick, Susan P Fisher-Hoch
BACKGROUND & AIMS: Hepatic fibrosis is a primary risk factor for cirrhosis and hepatocellular carcinoma, which affect a disproportionate number of Hispanics in the United States. We aimed to determine the prevalence of significant fibrosis, measured by point shear-wave elastography (pSWE), and determine characteristics of hepatic fibrosis and simple steatosis in a population-based study of Mexican American Hispanics in south Texas. METHODS: Liver stiffness was measured by pSWE, performed by 2 separate operators, for 406 participants in the Cameron County Hispanic Cohort from 2015 through 2017...
June 11, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29873275/hepatic-artery-resistive-index-as-surrogate-marker-for-fibrosis-progression-in-nafld-patients-a-clinical-perspective
#3
Claudio Tana, Cosima Schiavone, Andrea Ticinesi, Fulvio Lauretani, Antonio Nouvenne, Christoph Frank Dietrich, Tiziana Meschi
Ultrasound (US) can reveal the presence of steatosis in non-alcoholic fatty liver disease (NAFLD), but its diagnostic accuracy to reveal signs of fibrosis is low except in advanced stages of disease (e.g. cirrhosis). Current guidelines suggest the use of clinical algorithms, such as the NAFLD fibrosis score, and elastography to predict the progression of fibrosis, and the integration of elastography improves the detection accuracy of liver stiffness. However, there is a lack of evidence about the correlation between clinical algorithms and conventional US, and elastography is limited by the relative low diffusion, necessity of training, and loss of diagnostic accuracy in patients with high body mass index (BMI), waist circumference, or increased thickness of parietal walls, with consequent significant rates of failure of measurement of liver stiffness...
January 2018: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29863282/senescence-mirrors-the-extent-of-liver-fibrosis-in-chronic-hepatitis-c-virus-infection
#4
F Wandrer, B Han, S Liebig, J Schlue, M P Manns, K Schulze-Osthoff, H Bantel
BACKGROUND: Chronic viral hepatitis is linked to fibrotic liver injury that can progress to liver cirrhosis with its associated complications. Recent evidence suggests a role of senescence in liver fibrosis, although the senescence regulators contributing to fibrosis progression remain unclear. AIM: To investigate the role of senescence and different senescence markers for fibrosis progression in patients with chronic hepatitis C virus (HCV) infection. METHODS: The expression of the cell cycle inhibitors p21, p27 and p16 as well as the senescence markers p-HP1γ and γ-H2AX was analysed in liver tissue with different fibrosis stages...
June 4, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29785393/monitoring-methotrexate-induced-liver-fibrosis-in-patients-with-psoriasis-utility-of-transient-elastography
#5
REVIEW
Harriet S Cheng, Marius Rademaker
Increasingly, existing evidence indicates that methotrexate-associated liver injury is related to comorbid risk factors such as diabetes, alcoholism, and obesity, rather than to methotrexate itself. Despite this fact, significant effort continues to be expended in the monitoring of low-dose methotrexate in patients with psoriasis. The gold standard investigation has been liver biopsy, but this is associated with significant morbidity and mortality. As methotrexate-induced liver injury is uncommon, the risk/benefit ratio of liver biopsy has been questioned...
2018: Psoriasis: Targets and Therapy
https://www.readbyqxmd.com/read/29746172/pharmacological-decrease-of-liver-stiffness-is-pressure-related-and-predicts-long-term-clinical-outcome
#6
Felix Piecha, Mattias Mandorfer, Teresa Peccerella, Ann-Kathrin Ozga, Tanja Poth, Anna Vonbank, Helmut Karl Seitz, Vanessa Rausch, Thomas Reiberger, Sebastian Mueller
Liver stiffness (LS) as measured by transient elastography is increasingly used to non-invasively assess liver fibrosis. However, LS is efficiently modulated by confounders like arterial and portal pressure (PP). We here study the effect of acute hemodynamic changes on LS (measured by µFibroscan) in a rodent model of cirrhosis in response to pharmacological modulation of PP by losartan, NO-donors and propranolol. Additionally, changes of LS and the hepatic venous pressure gradient (HVPG) under propranolol therapy were assessed with regard to clinical outcomes in a human cohort of n=38 cirrhotic patients...
May 10, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29742149/the-il7ra-rs6897932-polymorphism-is-associated-with-progression-of-liver-fibrosis-in-patients-with-chronic-hepatitis-c-repeated-measurements-design
#7
María Ángeles Jiménez-Sousa, Ana Zaida Gómez-Moreno, Daniel Pineda-Tenor, Luz Maria Medrano, Juan José Sánchez-Ruano, Amanda Fernández-Rodríguez, Tomas Artaza-Varasa, José Saura-Montalbán, Sonia Vázquez-Morón, Pablo Ryan, Salvador Resino
The polymorphisms at the α-chain of the IL-7 receptor (IL7RA) have been related to T-cell homeostasis and development and may contribute to immune system deregulation. In the present study, we analyzed the association between IL7RA polymorphisms and the progression of liver fibrosis in patients infected with HCV. We carried out a retrospective study with a design consisting of repeated measurements in 187 HCV-infected patients, to study the risk prediction of liver fibrosis progression using genetic factors...
2018: PloS One
https://www.readbyqxmd.com/read/29730602/deep-learning-radiomics-of-shear-wave-elastography-significantly-improved-diagnostic-performance-for-assessing-liver-fibrosis-in-chronic-hepatitis-b-a-prospective-multicentre-study
#8
Kun Wang, Xue Lu, Hui Zhou, Yongyan Gao, Jian Zheng, Minghui Tong, Changjun Wu, Changzhu Liu, Liping Huang, Tian'an Jiang, Fankun Meng, Yongping Lu, Hong Ai, Xiao-Yan Xie, Li-Ping Yin, Ping Liang, Jie Tian, Rongqin Zheng
OBJECTIVE: We aimed to evaluate the performance of the newly developed deep learning Radiomics of elastography (DLRE) for assessing liver fibrosis stages. DLRE adopts the radiomic strategy for quantitative analysis of the heterogeneity in two-dimensional shear wave elastography (2D-SWE) images. DESIGN: A prospective multicentre study was conducted to assess its accuracy in patients with chronic hepatitis B, in comparison with 2D-SWE, aspartate transaminase-to-platelet ratio index and fibrosis index based on four factors, by using liver biopsy as the reference standard...
May 5, 2018: Gut
https://www.readbyqxmd.com/read/29696462/longitudinal-monitoring-of-liver-fibrosis-status-by-transient-elastography-in-chronic-hepatitis-b-patients-during-long-term-entecavir-treatment
#9
Sheng-Di Wu, Li-Li Liu, Ji-Lin Cheng, Yun Liu, Li-Sha Cheng, Si-Qi Wang, Wei Ma, Li-Ping Chen, Yu-Jen Tseng, Ji-Yao Wang, Xi-Zhong Shen, Wei Jiang
The correlation between improvement in longitudinal liver stiffness and fibrosis regression has not been properly evaluated during long-term antiviral therapy in chronic hepatitis B (CHB) patients. In this study, liver stiffness was serially performed by FibroScan® every 26 weeks in a prospective cohort of CHB patients receiving entecavir. Results were compared with liver biopsies at baseline and week 78. A total of 120 treatment-naïve CHB patients were analyzed, in which 54 (45%) patients had fibrosis regression at 78 weeks of antiviral therapy...
April 25, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29690726/-expanded-clinical-verification-of-effectiveness-of-two-dimensional-shear-wave-elastography-in-the-noninvasive-evaluation-of-hepatic-fibrosis
#10
Y Lin, H Ding, Y Zhuang, Y Zhang, Y L Zhu, W P Wang
Objective: To evaluate the diagnostic value of two-dimensional shear wave elastography(2D-SWE)in the assessment of hepatic fibrosis in a large-scale clinical setting. Methods: A total of 1 079 subjects who underwent partial hepatectomy were examined with 2D-SWE to measure liver stiffness before operation and the liver stiffness measurements were compared with histologic findings.The published cutoff values of liver stiffness examined with 2D-SWE were used as a reference, as 7.2, 9.2, and 10.4 kPa for diagnosing substantial fibrosis(S2), severe fibrosis(S3), and cirrhosis(S4), respectively...
April 17, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29674183/pnpla3-rs738409-polymorphism-is-associated-with-liver-fibrosis-progression-in-patients-with-chronic-hepatitis-c-a-repeated-measures-study
#11
María Ángeles Jiménez-Sousa, Ana Zaida Gómez-Moreno, Daniel Pineda-Tenor, Juan José Sánchez-Ruano, Amanda Fernández-Rodríguez, Tomas Artaza-Varasa, Alicia Gómez-Sanz, María Martín-Vicente, Sonia Vázquez-Morón, Salvador Resino
BACKGROUND: Host genetic background has been associated with liver fibrosis progression. OBJECTIVE: To analyze the association between the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism and liver fibrosis progression in hepatitis C virus (HCV)-infected patients. STUDY DESIGN: In this retrospective cohort study, 187 patients with chronic HCV infection were included, who had at least two liver stiffness measurements (LSM) by transient elastography during the follow-up...
June 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29662329/diagnosis-and-staging-of-fibrosis-in-patients-with-chronic-hepatitis-c-comparison-and-critical-overview-of-current-strategies
#12
REVIEW
Leandro César Mendes, Raquel Sb Stucchi, Aline G Vigani
In the past years, what has always been considered undisputed true in liver fibrosis staging has been challenged. Diagnostic performance of histological evaluation has proven to be significantly influenced by sample- and observer-related variabilities. Differentiation between lower levels of fibrosis remains difficult for many, if not all, test modalities, including liver biopsy but, perhaps, such a distinction is not indispensable in light of current therapeutic approaches. Biomarkers and elastography offer, nonetheless, high predictive values for advanced fibrosis and cirrhosis and correlate well with liver-related outcomes...
2018: Hepatic Medicine: Evidence and Research
https://www.readbyqxmd.com/read/29599606/serum-interleukin-34-level-can-be-an-indicator-of-liver-fibrosis-in-patients-with-chronic-hepatitis-b-virus-infection
#13
Yin-Qiu Wang, Wen-Jun Cao, Yu-Feng Gao, Jun Ye, Gui-Zhou Zou
AIM: To investigate whether serum interleukin (IL)-34 levels are correlated with hepatic inflammation and fibrosis in patients with chronic hepatitis B virus (HBV) infection. METHODS: In this study, serum IL-34 levels were assessed by enzyme-linked immunosorbent assay in 19 healthy controls and 175 patients with chronic HBV infection undergoing biopsy. The frequently used serological markers of liver fibrosis were based on laboratory indexes measured at the Clinical Laboratory of the Second Affiliated Hospital of Anhui Medical University...
March 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29579872/therapy-with-direct-acting-antiviral-agents-for-hepatitis-c-in-liver-transplant-recipients
#14
F Nogueras López, A López Garrido, E J Ortega Suazo, F Vadillo Calles, F Valverde López, M D Espinosa Aguilar
BACKGROUND: Recurrent infection with the hepatitis C virus (HCV) after liver transplantation (LT) is associated with decreased graft and patient survival. Direct-acting antiviral (DAA) therapies have changed the landscape of HCV due to their excellent safety profile and cure rates. Our aim was to evaluate the efficacy and tolerability of antiviral therapy in recurrent HCV after LT with DAA therapy. METHODS: Our retrospective analysis included 46 LT recipients with HCV recurrence...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29568207/fatty-liver-in-hepatitis-c-patients-post-sustained-virological-response-with-direct-acting-antivirals
#15
Mazen Noureddin, Micaela M Wong, Tsuyoshi Todo, Shelly C Lu, Arun J Sanyal, Edward A Mena
AIM: To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting antivirals. METHODS: Transient elastography with controlled attenuation parameter (CAP) was used to assess hepatic steatosis post-sustained virological response (SVR); the CAP technology was not available in the United States at study initiation. Liver stiffness/fibrosis was measured before and 47 wk after treatment completion...
March 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29531460/quantitative-and-noninvasive-assessment-of-chronic-liver-diseases-using-two-dimensional-shear-wave-elastography
#16
REVIEW
Li-Ting Xie, Chun-Hong Yan, Qi-Yu Zhao, Meng-Na He, Tian-An Jiang
Two-dimensional shear wave elastography (2D-SWE) is a rapid, simple and novel noninvasive method that has been proposed for assessing hepatic fibrosis in patients with chronic liver diseases (CLDs) based on measurements of liver stiffness. 2D-SWE can be performed easily at the bedside or in an outpatient clinic and yields immediate results with good reproducibility. Furthermore, 2D-SWE was an efficient method for evaluating liver fibrosis in small to moderately sized clinical trials. However, the quality criteria for the staging of liver fibrosis are not yet well defined...
March 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29391861/noninvasive-assessment-of-fibrosis-regression-in-hepatitis-c-virus-sustained-virologic-responders
#17
Hirsh D Trivedi, Steven C Lin, Daryl T Y Lau
The emergence of direct-acting antiviral (DAA) therapies and noninvasive measures of liver fibrosis has streamlined the management of patients with chronic hepatitis C virus (HCV) infection. DAA therapy is associated with a significantly higher rate of sustained virologic response (SVR) compared to interferon-based therapies. Concomitantly, validated noninvasive measures of fibrosis allow evaluation of patients for therapy without an invasive liver biopsy. Noninvasive measures of fibrosis can be classified as serologic tests or imaging modalities...
October 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29380413/non-invasive-assessments-for-liver-fibrosis-the-crystal-ball-we-long-for
#18
REVIEW
Grace Lai-Hung Wong
Non-invasive assessment of liver fibrosis has been one of the most rapidly advancing fields in hepatology in the last decade. Progressive liver fibrosis results in cirrhosis, hepatocellular carcinoma (HCC), and various liver-related complications in essentially all chronic liver diseases. Assessment of liver fibrosis allows clinicians to determine the prognosis, need of treatment, disease progression, and response to treatment in patients with chronic liver disease. Liver biopsy has been the gold standard in last few decades and most adopted diagnostic tool in clinical trials...
May 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29346443/exposure-to-previous-cart-is-associated-with-significant-liver-fibrosis-and-cirrhosis-in-human-immunodeficiency-virus-infected-patients
#19
Evrim Anadol, Kristina Lust, Christoph Boesecke, Carolynne Schwarze-Zander, Raphael Mohr, Jan-Christian Wasmuth, Jürgen Kurt Rockstroh, Jonel Trebicka
INTRODUCTION: Combined antiretroviral therapy (cART) has improved survival in HIV-patients. While the first antiretrovirals, which became available in particular D-drugs (especially didanosine and stavudine) and unboosted protease inhibitors, may impair liver function, the modern cART seems to decrease liver fibrosis. This study assessed the influence of exposure to previous antiretrovirals on liver fibrosis in HIV-infected patients. METHODS: This observational cross-sectional single-center study recruited 333 HIV patients and assessed liver fibrosis using transient elastography (TE)...
2018: PloS One
https://www.readbyqxmd.com/read/29284411/prediction-of-posthepatectomy-liver-failure-using-transient-elastography-in-patients-with-hepatitis-b-related-hepatocellular-carcinoma
#20
Jie-Wen Lei, Xiao-Yu Ji, Jun-Feng Hong, Wan-Bin Li, Yan Chen, Yan Pan, Jia Guo
BACKGROUND: It is essential to accurately predict Postoperative liver failure (PHLF) which is a life-threatening complication. Liver hardness measurement (LSM) is widely used in non-invasive assessment of liver fibrosis. The aims of this study were to explore the application of preoperative liver stiffness measurements (LSM) by transient elastography in predicting postoperative liver failure (PHLF) in patients with hepatitis B related hepatocellular carcinoma. METHODS: The study included 247 consecutive patients with hepatitis B related hepatocellular carcinoma who underwent hepatectomy between May 2015 and September 2015...
December 29, 2017: BMC Gastroenterology
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