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Hepatitis, liver, cirrhosis, elastography, fibrosis

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https://www.readbyqxmd.com/read/27910154/interferon-free-regimens-improve-portal-hypertension-and-histological-necroinflammation-in-hiv-hcv-patients-with-advanced-liver-disease
#1
P Schwabl, M Mandorfer, S Steiner, B Scheiner, D Chromy, M Herac, T Bucsics, H Hayden, K Grabmeier-Pfistershammer, A Ferlitsch, G Oberhuber, M Trauner, M Peck-Radosavljevic, T Reiberger
BACKGROUND: HIV/HCV co-infected patients show accelerated fibrosis progression and higher risk for complications of portal hypertension (PHT). AIM: To assess the effects of interferon-free therapy on portal pressure, liver histology and plasma biomarkers in HIV/HCV-coinfected patients with PHT. METHODS: Twenty-two patients with paired hepatic venous pressure gradient (HVPG) measurements prior and after successful treatment (SVR) with interferon-free regimens were included...
January 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27898593/coinfection-with-hiv-and-hepatitis-c-virus-in-229-children-and-young-adults-living-in-europe
#2
(no author information available yet)
OBJECTIVE: To characterize children, adolescents and young adults infected with HIV/hepatitis C virus (HCV) vertically or before age of 18 years and living in Europe regarding mode of acquisition, HCV genotype, clinical status and treatment. DESIGN: Retrospective, cross-sectional study using pooled data from 11 European paediatric HIV cohorts. METHODS: Patients aged more than 18 months and less than 25 years, with HIV/HCV acquired vertically or in childhood, were included...
January 2, 2017: AIDS
https://www.readbyqxmd.com/read/27859840/value-of-mr-elastography-for-the-preoperative-estimation-of-liver-regeneration-capacity-in-patients-with-hepatocellular-carcinoma
#3
Siwon Jang, Jeong Min Lee, Dong Ho Lee, Ijin Joo, Jeong Hee Yoon, Won Chang, Joon Koo Han
PURPOSE: To demonstrate the negative relationship between liver stiffness (LS) values measured at preoperative magnetic resonance elastography (MRE) and the regeneration capacity of the remnant liver after major hepatectomy, in patients with hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Thirty-eight patients with HCC (mean age, 57.1) who had undergone liver computed tomography (CT) and 1.5T MRE prior to right hepatectomy were included in this retrospective study...
November 16, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27803168/mortality-in-patients-with-chronic-hepatitis-c-and-cirrhosis-compared-to-the-general-population-a-danish-cohort-study
#4
Sofie Hallager, Peer Brehm Christensen, Steen Ladelund, Mette Rye Clausen, Alex Lund Laursen, Axel Møller, Poul Schlicthting, Lone Galmstrup Madsen, Jan Gerstoft, Suzanne Lunding, Karin Elmegaard Grønbæk, Henrik Bygum Krarup, Nina Weis
BACKGROUND:  Knowledge of mortality in patients with Chronic Hepatitis C (CHC) with cirrhosis is limited. This study aimed to estimate all-cause mortality among CHC patients with and without cirrhosis in Denmark compared to the general population. METHODS:  Patients registered in The Danish Database for Hepatitis B and C with CHC and a liver fibrosis assessment were eligible for inclusion. Liver fibrosis was based on liver biopsy, transient elastography, and clinical cirrhosis...
October 31, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27784440/-a-discussion-of-the-methods-for-the-assessment-of-chronic-hepatitis-b-related-liver-fibrosis-regression
#5
Y M Sun, X N Wu, J L Zhou, H You
Antiviral therapy could reverse hepatitis B-related liver fibrosis and early-stage cirrhosis. However, the assessment of fibrosis regression remains controversial. As the gold standard for assessment, liver biopsy has its own limitations. In terms of non-invasive assessment, there are many interfering factors for transient elastography and less clinical evidence for the use of serum markers. Therefore, further evidence from clinical studies is still needed to determine the role of non-invasive methods in evaluating fibrosis regression...
July 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27750231/comparison-of-two-dimensional-shear-wave-elastography-and-real-time-tissue-elastography-for-assessing-liver-fibrosis-in-chronic-hepatitis-b
#6
Tao Wu, Ping Wang, Ting Zhang, Jian Zheng, Shuoyang Li, Jie Zeng, Masatoshi Kudo, Rongqin Zheng
BACKGROUND: Noninvasive assessment of liver fibrosis has important clinical significance. Different techniques including two-dimensional shear-wave elastography (2D SWE) and real-time tissue elastography (RTE) are reported to be useful for the noninvasive diagnosis of hepatic fibrosis. All these techniques are affected by many factors. How to choose a reasonable method needs further studies. PURPOSE: This study was conducted to comparatively assess the diagnostic performance of 2D SWE and RTE in patients with Chronic Hepatitis B (CHB) and influence of inflammation on the stiffness values obtained by both techniques, so as to objectively assess the reasonable choice between these 2 elastography techniques for noninvasive assessment of hepatic fibrosis in clinical practice...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/27743352/evaluating-the-relationship-between-metabolic-syndrome-and-liver-biopsy-proven-non-alcoholic-steatohepatitis-in-china-a-multicenter-cross-sectional-study-design
#7
Zheng-Jie Xu, Jun-Ping Shi, De-Rong Yu, Li-Juan Zhu, Ji-Dong Jia, Jian-Gao Fan
INTRODUCTION: Non-alcoholic steatohepatitis (NASH) is a serious form of non-alcoholic fatty liver disease (NAFLD) that can progress to advanced fibrosis, cirrhosis, and hepatocellular carcinoma. Differentiating between non-alcoholic fatty liver (NAFL) and NASH/advanced fibrosis is an important step in the management of NAFLD. Metabolic syndrome (MS) and its components are important risk factors for NAFLD, and NASH is thought to be the hepatic injury of MS. The prevalence of NASH among NAFLD patients with MS is thought to be high...
October 14, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27729738/prediction-models-of-hepatocellular-carcinoma-development-in-chronic-hepatitis-b-patients
#8
Hye Won Lee, Sang Hoon Ahn
Chronic hepatitis B virus (HBV) infection is a major cause of cirrhosis and hepatocellular carcinoma (HCC). Applying the same strategies for antiviral therapy and HCC surveillance to all chronic hepatitis B (CHB) patients would be a burden worldwide. To properly manage CHB patients, it is necessary to identify and classify the risk for HCC development in such patients. Several HCC risk scores based on risk factors such as cirrhosis, age, male gender, and high viral load have been used, and have negative predictive values of ≥ 95%...
October 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27714681/asian-pacific-association-for-the-study-of-the-liver-apasl-consensus-guidelines-on-invasive-and-non-invasive-assessment-of-hepatic-fibrosis-a-2016-update
#9
Gamal Shiha, Alaa Ibrahim, Ahmed Helmy, Shiv Kumar Sarin, Masao Omata, Ashish Kumar, David Bernstien, Hitushi Maruyama, Vivek Saraswat, Yogesh Chawla, Saeed Hamid, Zaigham Abbas, Pierre Bedossa, Puja Sakhuja, Mamun Elmahatab, Seng Gee Lim, Laurentius Lesmana, Jose Sollano, Ji-Dong Jia, Bahaa Abbas, Ashraf Omar, Barjesh Sharma, Diana Payawal, Ahmed Abdallah, Abdelhamid Serwah, Abdelkhalek Hamed, Aly Elsayed, Amany AbdelMaqsod, Tarek Hassanein, Ahmed Ihab, Hamsik GHaziuan, Nizar Zein, Manoj Kumar
Hepatic fibrosis is a common pathway leading to liver cirrhosis, which is the end result of any injury to the liver. Accurate assessment of the degree of fibrosis is important clinically, especially when treatments aimed at reversing fibrosis are being evolved. Despite the fact that liver biopsy (LB) has been considered the "gold standard" of assessment of hepatic fibrosis, LB is not favored by patients or physicians owing to its invasiveness, limitations, sampling errors, etc. Therefore, many alternative approaches to assess liver fibrosis are gaining more popularity and have assumed great importance, and many data on such approaches are being generated...
October 6, 2016: Hepatology International
https://www.readbyqxmd.com/read/27690214/low-pretreatment-acoustic-radiation-force-impulse-imaging-arfi-values-predict-sustained-virological-response-in-antiviral-hepatitis-c-virus-hcv-therapy
#10
Steffen Zopf, Lara Rösch, Peter C Konturek, Ruediger S Goertz, Markus F Neurath, Deike Strobel
BACKGROUND Non-invasive procedures such as acoustic radiation force impulse imaging (ARFI) shear-wave elastography are currently used for the assessment of liver fibrosis. In the course of chronic hepatitis C, significant liver fibrosis or cirrhosis develops in approximately 25% of patients, which is a negative predictor of antiviral treatment response. Cirrhosis can be prevented by successful virus elimination. In this prospective study, a pretreatment ARFI cutoff value of 1.5 m/s was evaluated in relation to sustained virological response to anti-HCV therapy...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27689833/elastography-in-chronic-liver-disease-modalities-techniques-limitations-and-future-directions
#11
Aparna Srinivasa Babu, Michael L Wells, Oleg M Teytelboym, Justin E Mackey, Frank H Miller, Benjamin M Yeh, Richard L Ehman, Sudhakar K Venkatesh
Chronic liver disease has multiple causes, many of which are increasing in prevalence. The final common pathway of chronic liver disease is tissue destruction and attempted regeneration, a pathway that triggers fibrosis and eventual cirrhosis. Assessment of fibrosis is important not only for diagnosis but also for management, prognostic evaluation, and follow-up of patients with chronic liver disease. Although liver biopsy has traditionally been considered the reference standard for assessment of liver fibrosis, noninvasive techniques are the emerging focus in this field...
September 30, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27672283/role-of-spleen-elastography-in-patients-with-chronic-liver-diseases
#12
REVIEW
Mariangela Giunta, Dario Conte, Mirella Fraquelli
The development of liver cirrhosis and portal hypertension (PH), one of its major complications, are structural and functional alterations of the liver, occurring in many patients with chronic liver diseases (CLD). Actually the progressive deposition of hepatic fibrosis has a key role in the prognosis of CLD patients. The subsequent development of PH leads to its major complications, such as ascites, hepatic encephalopathy, variceal bleeding and decompensation. Liver biopsy is still considered the reference standard for the assessment of hepatic fibrosis, whereas the measurement of hepatic vein pressure gradient is the standard to ascertain the presence of PH and upper endoscopy is the method of choice to detect the presence of oesophageal varices...
September 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27603289/nonalcoholic-fatty-liver-disease-diagnosed-by-transient-elastography-with-controlled-attenuation-parameter-in-unselected-hiv-monoinfected-patients
#13
Élise Vuille-Lessard, Bertrand Lebouché, Lynda Lennox, Jean-Pierre Routy, Cecilia T Costiniuk, Costa Pexos, Andreas Giannakis, Jason Szabo, Marina B Klein, Giada Sebastiani
OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in Western countries. HIV-infected persons without viral hepatitis are at increased risk of NAFLD. Nevertheless, data on NAFLD in HIV monoinfection are scarce. DESIGN/METHODS: We prospectively investigated prevalence and predictors of NAFLD and liver fibrosis by transient elastography and associated controlled attenuation parameter (CAP) in unselected HIV-infected adults without significant alcohol intake or viral hepatitis coinfection...
November 13, 2016: AIDS
https://www.readbyqxmd.com/read/27601240/virtual%C3%A2-touch%C3%A2-quantification-to-diagnose-and-monitor-liver-fibrosis-in-hepatitis-b-and-hepatitis-c-a-nice-medical-technology-guidance
#14
Jennifer A Summers, Muralikrishnan Radhakrishnan, Elizabeth Morris, Anastasia Chalkidou, Tiago Rua, Anita Patel, Viktoria McMillan, Abdel Douiri, Yanzhong Wang, Salma Ayis, Joanne Higgins, Stephen Keevil, Cornelius Lewis, Janet Peacock
Virtual Touch™ Quantification (VTq) is a software application used with Siemens Acuson ultrasound scanners to assess the stiffness of liver tissue. The National Institute for Health and Care Excellence (NICE) Medical Technologies Advisory Committee (MTAC) selected VTq for evaluation and invited the company to submit clinical and economic evidence. King's Technology Evaluation Centre, an External Assessment Centre (EAC) commissioned by NICE, independently assessed the evidence submitted. The EAC conducted its own systematic review, meta-analysis and economic analysis to supplement the company's submitted evidence...
September 7, 2016: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/27595094/elevated-serum-levels-of-the-antiapoptotic-protein-decoy-receptor-3-are-associated-with-advanced-liver-disease
#15
Giorgos Bamias, Michalis Gizis, Ioanna Delladetsima, Eyfrosyni Laoudi, Spyros I Siakavellas, Ioannis Koutsounas, Garyfallia Kaltsa, John Vlachogiannakos, Irene Vafiadis-Zouboulis, George L Daikos, George V Papatheodoridis, Spiros D Ladas
Background. Decoy-receptor 3 (DcR3) exerts antiapoptotic and immunomodulatory function and is overexpressed in neoplastic and inflammatory conditions. Serum DcR3 (sDcR3) levels during the chronic hepatitis/cirrhosis/hepatocellular carcinoma (HCC) sequence have not been explored. Objective. To assess the levels and significance of sDcR3 protein in various stages of chronic liver disease. Methods. We compared sDcR3 levels between healthy controls and patients with chronic viral hepatitis (CVH), decompensated cirrhosis (DC), and HCC...
2016: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27575867/accuracy-of-liver-surface-nodularity-quantification-on-mdct-as-a-noninvasive-biomarker-for-staging-hepatic-fibrosis
#16
Perry J Pickhardt, Kyle Malecki, John Kloke, Meghan G Lubner
OBJECTIVE: The purpose of this study was to investigate objective semiautomated measurement of liver surface nodularity on MDCT for prediction of underlying hepatic fibrosis (stages F0-F4). MATERIALS AND METHODS: Contrast-enhanced abdominal MDCT scans were assessed with an independently validated semiautomated surface nodularity tool. A series of 10 or more consecutive ROI measurements along the anterior aspect of the liver totaling a length of 80 cm or more were made with the left lateral segment as the default...
December 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27573619/development-of-a-model-based-on-biochemical-real%C3%A2-time-tissue-elastography-and-ultrasound-data-for-the-staging-of-liver-fibrosis-and-cirrhosis-in-patients-with-chronic-hepatitis-b
#17
Shi-Hao Xu, Qiao Li, Yuan-Ping Hu, Li Ying
The liver fibrosis index (LFI), based on real‑time tissue elastography (RTE), is a method currently used to assess liver fibrosis. However, this method may not consistently distinguish between the different stages of fibrosis, which limits its accuracy. The aim of the present study was to develop novel models based on biochemical, RTE and ultrasound data for predicting significant liver fibrosis and cirrhosis. A total of 85 consecutive patients with chronic hepatitis B (CHB) were prospectively enrolled and underwent a liver biopsy and RTE...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27563019/magnetic-resonance-elastography-and-other-magnetic-resonance-imaging-techniques-in-chronic-liver-disease-current-status-and-future-directions
#18
REVIEW
Cher Heng Tan, Sudhakar Kundapur Venkatesh
Recent advances in the noninvasive imaging of chronic liver disease have led to improvements in diagnosis, particularly with magnetic resonance imaging (MRI). A comprehensive evaluation of the liver may be performed with the quantification of the degree of hepatic steatosis, liver iron concentration, and liver fibrosis. In addition, MRI of the liver may be used to identify complications of cirrhosis, including portal hypertension, ascites, and the development of hepatocellular carcinoma. In this review article, we discuss the state of the art techniques in liver MRI, namely, magnetic resonance elastography, hepatobiliary phase MRI, and liver fat and iron quantification MRI...
September 15, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27540438/ultrasound-elastography-used-for-preventive-non-invasive-screening-in-early-detection-of-liver-fibrosis
#19
Florian Bert, Jona T Stahmeyer, Siegbert Rossol
BACKGROUND: Early discovery of liver fibrosis is becoming more popular because of enhanced incidence of hepatocellular carcinoma. Ultrasound-based liver elastography is a method used to approve suspected liver fibrosis or cirrhosis. We assessed the clinical usefulness of acoustic radiation force impulse shear wave elasticity imaging (ARFI-SWEI) as a preventive screening method to uncover fibrosis. METHODS: We screened 382 patients by native routine sonography for abnormal liver results and divided them into six groups: group 1: normal liver, groups 2-4: fatty liver grade I-III, group 5: liver cirrhosis, and group 6: inhomogenic liver tissue...
September 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27533769/transient-elastography-and-apri-score-looking-at-false-positives-and-false-negatives-diagnostic-performance-and-association-to-fibrosis-staging-in-chronic-hepatitis-c
#20
L C Mendes, P A Ferreira, N Miotto, L Zanaga, E Gonçales, M S Lazarini, F L Gonçales, R S B Stucchi, A G Vigani
Although long regarded as the gold standard for liver fibrosis staging in chronic hepatitis C (CHC), liver biopsy (LB) implies both the risk of an invasive procedure and significant variability. The aim of this study was to evaluate the diagnostic performance for transient elastography (TE) and aspartate aminotransferase to platelet index (APRI) used alone and in combination compared to liver biopsy and to analyze false positive/negative results. Patients with CHC, and no previous clinical diagnosis of cirrhosis were enrolled to undergo liver biopsy, TE and APRI...
August 1, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
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