keyword
https://read.qxmd.com/read/38407666/training-healthcare-professionals-to-administer-goal-attainment-scaling-as-an-outcome-measure
#21
RANDOMIZED CONTROLLED TRIAL
Benignus Logan, Andrea K Viecelli, Elaine M Pascoe, Bonnie Pimm, Laura E Hickey, David W Johnson, Ruth E Hubbard
BACKGROUND: Goals generated by Goal Attainment Scaling (GAS) can be used as an outcome measure to promote person-centred research and care. There are no training packages which support its use outside of the rehabilitation discipline. This paper describes the development and evaluation of a training package to support the implementation of GAS as an outcome measure in healthcare research. The training package consisted of classroom teaching, a training manual for self-directed learning, one-on-one simulation and hot reviews...
February 26, 2024: Journal of Patient-Reported Outcomes
https://read.qxmd.com/read/38406047/paradoxical-and-unmasking-hiv-immune-reconstitution-inflammation-syndrome-in-antiretroviral-na%C3%A3-ve-pregnant-women-a-prospective-cohort-study
#22
JOURNAL ARTICLE
John K Muthuka, Everlyn M Nyamai, Kelly Oluoch, Charles Maibvise, Rosemary Nabaweesi
BACKGROUND AND AIMS: Following antiretroviral therapy (ART) initiation, HIV-associated immune reconstitution inflammatory syndrome (IRIS), indicated by an array of opportunistic infections, may occur, presenting as either paradoxical, a worsening of a previously treated infection, or unmasking, a flare-up of an underlying, previously undiagnosed infection. The impact of ART as the backbone of HIV treatment and prevention has prolonged the survival of people living with HIV. In pregnancy, benefits have been shown by slowing HIV progression and preventing perinatal transmission; however, there have been risks of adverse reactions with ART, including immune responses to both the fetus and mother...
January 2024: Curēus
https://read.qxmd.com/read/38395726/numerical-biomechanical-finite-element-analysis-of-different-trimming-line-designs-of-orthodontic-aligners-an-in-silico-study
#23
JOURNAL ARTICLE
Tarek M Elshazly, Christoph Bourauel, Philippe Chavanne, Hanaa Elattar, Ludger Keilig
BACKGROUND: A finite element model was used to investigate the effect of different designs and thicknesses of orthodontic aligner margins on their biomechanical behavior. METHODS: A three-dimensional data set of an upper jaw was imported into the 3-matic software. The upper right central incisor tooth (Tooth 11) was separated from the remaining model, and its periodontal ligament and surrounding bone were designed. Aligners were designed with four different trimming lines (scalloped, straight, scalloped extended, straight extended), each with four different thicknesses (0...
February 22, 2024: Journal of the World Federation of Orthodontists
https://read.qxmd.com/read/38393660/neuroign-explainable-multimodal-image-guided-system-for-precise-brain-tumor-surgery
#24
JOURNAL ARTICLE
Ramy A Zeineldin, Mohamed E Karar, Oliver Burgert, Franziska Mathis-Ullrich
Precise neurosurgical guidance is critical for successful brain surgeries and plays a vital role in all phases of image-guided neurosurgery (IGN). Neuronavigation software enables real-time tracking of surgical tools, ensuring their presentation with high precision in relation to a virtual patient model. Therefore, this work focuses on the development of a novel multimodal IGN system, leveraging deep learning and explainable AI to enhance brain tumor surgery outcomes. The study establishes the clinical and technical requirements of the system for brain tumor surgeries...
February 23, 2024: Journal of Medical Systems
https://read.qxmd.com/read/38391289/thoracic-aortic-aneurysms-a-single-center-s-10-years-experience-and-analysis-of-outcomes
#25
JOURNAL ARTICLE
Leonor Baldaia, Mariana Duque, Miguel Silva, Eduardo Silva, Celso Nunes, Vânia Constâncio, Luís Orelhas, Manuel Fonseca, Luís F Antunes
INTRODUCTION: Thoracic aortic aneurysms (TAAs) are an increasingly prevalent pathology with significant associated morbidity and mortality. Thoracic endovascular aortic repair (TEVAR) is the primary line of treatment. The purpose of this study was to analyse a single center's experience in the treatment of TAAs and identify possible risk factors for worse outcomes. METHODS: A retrospective review of our institutional database was done to identify all patients treated for TAAs in a 10-year period, from 1 January 2012 to 31 December 2022...
February 23, 2024: Vascular
https://read.qxmd.com/read/38390260/malignant-mixed-mullerian-tumors-a-seer-database-review-of-rurality-and-treatment-modalities-on-disease-outcome
#26
JOURNAL ARTICLE
Neusha Zadeh, Arjun Bhatt, Vaishnavi Sripiparu, Melisa Pasli, George Edwards, Michael C Larkins, M Sean Peach
INTRODUCTION: Malignant Mixed Mullerian Tumors (MMMT) are rare and poorly understood sarcomas with limited research on risk factors, pathogenesis, and optimal treatments. This study aimed to address this knowledge gap and explore the impact of community size, patient characteristics, disease characteristics, and treatment modalities on MMMT outcomes. METHODS: Using the Surveillance, Epidemiology, and End Results database (SEER), the largest SEER cohort to date of 3,352 MMMT patients was analyzed for demographic factors, treatment modalities, and histologic characteristics...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38381752/differentiated-care-for-youth-in-zimbabwe-outcomes-across-the-hiv-care-cascade
#27
JOURNAL ARTICLE
Chido Dziva Chikwari, Katharina Kranzer, Victoria Simms, Amani Patel, Mandikudza Tembo, Owen Mugurungi, Edwin Sibanda, Onismo Mufare, Lilian Ndlovu, Joice Muzangwa, Rumbidzayi Vundla, Abigail Chibaya, Richard Hayes, Constance Mackworth-Young, Sarah Bernays, Constancia Mavodza, Fadzanayi Hove, Tsitsi Bandason, Ethel Dauya, Rashida Abbas Ferrand
Youth living with HIV are at higher risk than adults of disengaging from HIV care. Differentiated models of care such as community delivery of antiretroviral therapy (ART) may improve treatment outcomes. We investigated outcomes across the HIV cascade among youth accessing HIV services in a community-based setting. This study was nested in a cluster-randomised controlled trial (CHIEDZA: Clinicaltrials.gov, Registration Number: NCT03719521) conducted in three provinces in Zimbabwe and aimed to investigate the impact of a youth-friendly community-based package of HIV services, integrated with sexual and reproductive health services for youth (16-24 years), on population-level HIV viral load (VL)...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38380017/development-and-implementation-of-a-prognostic-model-for-clear-cell-renal-cell-carcinoma-based-on-heterogeneous-tlr4-expression
#28
JOURNAL ARTICLE
Qingbo Zhou, Qiang Sun, Qi Shen, Xinsheng Li, Jijiang Qian
OBJECTIVE: Clear cell renal cell carcinoma (ccRCC) is the most common subtype among renal cell carcinomas and has the worst prognosis, originating from renal tubular epithelial cells. Toll-like receptor 4 (TLR4) plays a crucial role in ccRCC proliferation, infiltration, and metastasis. The aim of this study was to construct a prognostic scoring model for ccRCC based on TLR4 expression heterogeneity and to explore its association with immune infiltration, thereby providing insights for the treatment and prognostic evaluation of ccRCC...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38379705/drug-related-side-effects-and-adverse-reactions-in-the-treatment-of-migraine-a-bibliometric-and-visual-analysis
#29
JOURNAL ARTICLE
Shijie Wei, Hao Lv, Dianhui Yang, Lili Zhang, Xuhao Li, Yike Ning, Yu Tang, Xinyu Wu, Jing Han
BACKGROUND: Migraine imposes a substantial global burden, impacting patients and society. Pharmacotherapy, as a primary treatment, entails specific adverse reactions. Emphasizing these reactions is pivotal for improving treatment strategies and enhancing patients' well-being. Thus, we conducted a comprehensive bibliometric and visual analysis of relevant literature. METHODOLOGY: We conducted a comprehensive search on the Science Citation Index Expanded within the Web of Science, restricting the literature for analysis based on criteria such as document type, publication date, and language...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38378441/subcutaneous-immunoglobulin-replacement-therapy-in-patients-with-immunodeficiencies-impact-of-drug-packaging-and-administration-method-on-patient-reported-outcomes
#30
JOURNAL ARTICLE
R Mallick, G Solomon, P Bassett, X Zhang, P Patel, O Lepeshkina
BACKGROUND: Here, the perspective of patients with primary and secondary immunodeficiency receiving subcutaneous immunoglobulin (SCIg) via introductory smaller size pre-filled syringes (PFS) or vials were compared. METHODS: An online survey was conducted in Canada by the Association des Patients Immunodéficients du Québec (APIQ) (10/2020-03/2021). Survey questions included: reasons for choosing SCIg packaging and administration methods, training experiences, infusion characteristics, and switching methods...
February 20, 2024: BMC Immunology
https://read.qxmd.com/read/38370403/a-new-4-gene-based-prognostic-model-accurately-predicts-breast-cancer-prognosis-and-immunotherapy-response-by-integrating-wgcna-and-bioinformatics-analysis
#31
JOURNAL ARTICLE
Wenlong Chen, Yakun Kang, Wenyi Sheng, Qiyan Huang, Jiale Cheng, Shengbin Pei, You Meng
BACKGROUND: Breast cancer (BRCA) is a common malignancy in women, and its resistance to immunotherapy is a major challenge. Abnormal expression of genes is important in the occurrence and development of BRCA and may also affect the prognosis of patients. Although many BRCA prognosis model scores have been developed, they are only applicable to a limited number of disease subtypes. Our goal is to develop a new prognostic score that is more accurate and applicable to a wider range of BRCA patients...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38368267/reactive-oxygen-correlated-photothermal-imaging-of-smart-cof-nanoreactors-for-monitoring-chemodynamic-sterilization-and-promoting-wound-healing
#32
JOURNAL ARTICLE
Xiaohong Zhu, Tiantian Feng, Yidan Chen, Yan Xiao, Wei Wen, Shengfu Wang, Dong Wang, Xiuhua Zhang, Jichao Liang, Huayu Xiong
Chemodynamic therapy (CDT) has emerged as a promising approach for treating infected diabetic wounds, while reliable imaging technology for simultaneous monitoring of ROS and therapeutic processes is still a formidable challenge. Herein, smart covalent organic framework (COF) nanoreactors (COF NRs) are constructed by hyaluronic acid (HA) packaged glucose oxidase (GOx) covalently linked Fe-COF for diabetic wound healing. Upon the breakdown of the HA protective layer, GOx consumes glucose to produce gluconic acid and hydrogen peroxide (H2 O2 ), resulting in decreased local pH and H2 O2 supplementation...
February 17, 2024: Small
https://read.qxmd.com/read/38362682/identification-and-characterization-of-prognosticmacrophage-subpopulations-for-humanesophagealcarcinoma
#33
JOURNAL ARTICLE
Penghui Li, Xiaohui Gao, Di Huang, Xinyu Gu
AIMS: The aim of the present study was to investigate the relationship between the cellular ecosystem and the progression of esophageal carcinoma (ESCA) based on the evolution of macrophages and to analyze the potential of using macrophages as a new therapeutic approach in ESCA treatment. BACKGROUND: Macrophage-based immunotherapy could be used for treating ESCA patients, but its clinical application is limited by the intra-tumor heterogeneity of macrophages. OBJECTIVE: The objective of this study was to analyze the diversity, differentiation trajectory, and intercellular communication of macrophages in ESCA and its prognostic significance...
February 14, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38362159/long-term-effectiveness-and-cost-effectiveness-of-guided-internet-based-cognitive-behavioral-therapy-for-obsessive-compulsive-disorder-24-month-follow-up
#34
JOURNAL ARTICLE
Kazuki Matsumoto, Sayo Hamatani, Eiji Shimizu
This study investigated the long-term effectiveness and cost-effectiveness of guided internet-based cognitive behavioral therapy (ICBT) for obsessive-compulsive disorder (OCD). Twenty-five patients with OCD who had undergone guided ICBT in a randomized controlled trial or a single-arm trial were followed up for 6, 12, and 24 months. Missing data were imputed using the mice package in R, and a one-way analysis of variance with repeated measures was performed. The total Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score significantly decreased from baseline to all endpoints (p  < 0...
March 2024: Internet Interventions
https://read.qxmd.com/read/38360865/mapping-aml-heterogeneity-multi-cohort-transcriptomic-analysis-identifies-novel-clusters-and-divergent-ex-vivo-drug-responses
#35
JOURNAL ARTICLE
Jeppe F Severens, E Onur Karakaslar, Bert A van der Reijden, Elena Sánchez-López, Redmar R van den Berg, Constantijn J M Halkes, Peter van Balen, Hendrik Veelken, Marcel J T Reinders, Marieke Griffioen, Erik B van den Akker
Subtyping of acute myeloid leukaemia (AML) is predominantly based on recurrent genetic abnormalities, but recent literature indicates that transcriptomic phenotyping holds immense potential to further refine AML classification. Here we integrated five AML transcriptomic datasets with corresponding genetic information to provide an overview (n = 1224) of the transcriptomic AML landscape. Consensus clustering identified 17 robust patient clusters which improved identification of CEBPA-mutated patients with favourable outcomes, and uncovered transcriptomic subtypes for KMT2A rearrangements (2), NPM1 mutations (5), and AML with myelodysplasia-related changes (AML-MRC) (5)...
February 15, 2024: Leukemia
https://read.qxmd.com/read/38352887/predictors-of-antibiogram-performance-and-antibiotic-resistance-patterns-in-the-northern-syrian-region-a-cross-sectional-investigation
#36
JOURNAL ARTICLE
Nour Bourgi, Abd Alrahman Olaby, Ali Najdi, Georges Hatem
INTRODUCTION: Antibiogram use is crucial in the fight against antibiotic resistance in Syria, helping to guide treatment decisions, monitor resistance trends, and implement measures to mitigate this global health threat. This study explores the predictors of antibiogram performance and antibiotic resistance patterns in hospital settings in the Northern Syrian region. METHODS: An observational cross-sectional study was performed over six months, from the beginning of September 2022 to February 2023, targeting patients admitted to two hospitals in Syria with susceptibility to infection...
March 2024: Explor Res Clin Soc Pharm
https://read.qxmd.com/read/38352668/essential-health-services-delivery-status-during-covid-19-pandemic-in-ethiopia-a-national-mixed-methods-survey-of-primary-healthcare-units
#37
JOURNAL ARTICLE
Elias Ali Yesuf, Biru Abdisa, Habtamu Sime, Enku Kifle Alemu, Netsanet Abera Asseffa, Meskerem Jisso, Alemu Tamiso, Akalewold Alemayehu, Rekiku Fikre, Abdurezak Umer, Mesfin Kebede, Hussen Mohammed, Bekele Yazie, Kassu Ketema Gurmu, Kassahun Dessie Gashu, Dessies Abebaw Angaw, Berhanu Fikadie Endehabtu, Binyam Tilahun, Tajebew Zayede Gonete
BACKGROUND: Essential health services are a package of services critical to improve health outcomes. COVID-19 pandemic disrupts essential health services. However, the level of essential health service disruption due to COVID-19 in Ethiopia is not clear. This study aimed at measuring the status of delivery of essential health services in Ethiopia during COVID-19. METHODS: A national mixed-methods cross-sectional survey was conducted. It was undertaken in Amhara (10 districts), Oromia (eight districts), Sidama (six districts), Southern Nations, Nationalities, and People's Region (16 districts), and Dire Dawa City Administration...
October 2023: Ethiopian Journal of Health Sciences
https://read.qxmd.com/read/38344679/itga11-a-prognostic-factor-associated-with-immunity-in-gastric-adenocarcinoma
#38
JOURNAL ARTICLE
XiaoYing Yang, Mengda Wei, YanQing Huang, Xi Yang, ZhenMin Yuan, JunJie Huang, JunRen Wei, Lei Tian
BACKGROUND: Stomach adenocarcinoma (STAD) presents a challenge given its advanced stage at diagnosis and poor prognosis. Integrin subunit alpha 11 (ITGA11) encodes alpha integrin and has been implicated in promoting tumorigenesis and development by participating in cell proliferation and invasion. However, the precise mechanism of ITGA11 in STAD remains unclear. METHODS: The differences in ITGA11 expression levels between 375 gastric cancer samples and 32 paracancerous tissue samples from the Cancer Genome Atlas (TCGA) database were examined...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38343537/molecular-mechanisms-of-pancreatic-cancer-liver-metastasis-the-role-of-pak2
#39
JOURNAL ARTICLE
Hao Yang, Zhongyi Li, Shiqi Zhu, Wenxia Wang, Jing Zhang, Dongxu Zhao, Man Zhang, Wenxin Zhu, Wei Xu, Chunfang Xu
BACKGROUND: Pancreatic cancer remains an extremely malignant digestive tract tumor, posing a significant global public health burden. Patients with pancreatic cancer, once metastasis occurs, lose all hope of cure, and prognosis is extremely poor. It is important to investigate liver metastasis of Pancreatic cancer in depth, not just because it is the most common form of metastasis in pancreatic cancer, but also because it is crucial for treatment planning and prognosis assessment. This study aims to delve into the mechanisms of pancreatic cancer liver metastasis, with the goal of providing crucial scientific groundwork for the development of future treatment methods and drugs...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38336691/structured-counselling-and-regular-telephonic-follow-up-to-improve-referral-flow-and-compliance-in-nepal-for-diabetic-retinopathy-screen-d-study-a-randomised-controlled-trial
#40
JOURNAL ARTICLE
Binita Bhattarai, Hari Bahadur Thapa, Sandip Bashyal, Sarasawati Khadka Thapa, Sirshendu Chaudhuri, Varun Agiwal, Hira Pant, Samiksha Singh, Hemant Mahajan
BACKGROUND: Diabetic Retinopathy (DR) is an emerging public health issue, leading to severe visual impairment or blindness. Early identification and prompt treatment play a key role in achieving good visual outcomes. The objective of the study was to estimate the effectiveness of SCREEN package on improving referral compliance from peripheral centres to a tertiary eye centre in Nepal. METHODS: In this facility-based cluster-randomized trial, ten out of 19 referring centres of the tertiary eye care centre in Lumbini zone, Nepal were randomized into intervention and control groups...
February 10, 2024: BMC Health Services Research
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