keyword
https://read.qxmd.com/read/38497886/5-signature-genes-revealed-by-single-cell-profiling-identified-unique-immune-subtypes-affecting-the-prognosis-of-ovarian-cancer
#1
JOURNAL ARTICLE
S-Y Xiang, Q-K Li, Z Yang, Q Yi
OBJECTIVE: Ovarian cancer (OC) ranks among the most prevalent gynecological malignancies, with surgery, chemotherapy, and immunotherapy constituting primary treatment modalities. However, despite advancements, immunotherapy, particularly immune checkpoint inhibitors, has yielded suboptimal outcomes. The pressing need to identify biomarkers predictive of clinical prognosis underscores our objective. We aim to discern gene signatures and establish prognostic subgroups, specifically in the context of immunotherapy and chemotherapy, guiding clinical decision-making...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38493693/designing-a-predictive-framework-immune-related-gene-based-nomogram-and-prognostic-model-for-kidney-renal-papillary-cell-carcinoma
#2
JOURNAL ARTICLE
Adrian Lim, Mouad Edderkaoui, Yi Zhang, Qiang Wang, Ruoxiang Wang, Stephen J Pandol, Yan Ou
BACKGROUND: Kidney renal papillary cell carcinoma (KIRP) is frequently associated with an unfavorable prognosis for affected individuals. Unfortunately, there has been insufficient exploration in search for a reliable prognosis signature and predictive indicators to forecast outcomes for KIRP patients. AIM: The aim of this study is to employ a comprehensive analysis of data for the identification of prognosis genes, leading to the development of a nomogram with strong predictive capabilities...
March 16, 2024: International Immunopharmacology
https://read.qxmd.com/read/38491962/quantifying-preferences-for-urea-cycle-disorder-treatments-using-a-discrete-choice-experiment
#3
JOURNAL ARTICLE
Josiah Edelblut, Jeffrey R Skaar, John Hilton, Matthew Seibt, Kyle Martin, Nandini Hadker, Adrian Quartel, Robert D Steiner
Aims : Urea cycle disorders (UCDs) can cause ammonia accumulation and central nervous system toxicity. Nitrogen-binding medications can be efficacious but certain attributes may negatively impact adherence. This study sought to quantify the administration-related attributes influencing overall prescription selection and patient adherence. Methods: A web-based, quantitative survey including discrete choice experiment (DCE) methodology captured responses from health care providers for patients with UCDs. A series of hypothetical treatment profile sets with attributes such as route of administration, taste/odor, preparation instructions, packaging, dose measurement, and weight use restrictions were presented...
March 16, 2024: Journal of Medical Economics
https://read.qxmd.com/read/38485489/evaluating-a-rehabilitative-intervention-for-substance-dependent-patients-with-and-without-their-accompanying-children-in-germany-kontextsucht-study-protocol-for-a-non-randomised-trial
#4
JOURNAL ARTICLE
Ananda Stullich, Laura Hoffmann, Johannes Stephan, Jan Gehrmann, Matthias Richter
INTRODUCTION: People suffering from substance use disorders often live in social contexts with children or are parents themselves. Addicted parents show specific substance-related problems while raising their children, which often leads to various lifelong consequences for the children. The German rehabilitative treatment system allows bringing children to inpatient treatment centres. This mixed-methods study evaluates a newly developed intervention, called 'KontextSucht' or 'AddictionContext', for parents in rehabilitation treatment centres concerning the effectiveness of the intervention in parenting and abstinence outcome...
March 14, 2024: BMJ Open
https://read.qxmd.com/read/38480542/nomogram-predictive-models-for-adult-patients-with-acute-lymphoblastic-leukaemia-based-on-real-world-treatment-outcomes
#5
JOURNAL ARTICLE
Yi Chen, Yanxin Chen, Zhengjun Wu, Jiazheng Li, Yan Huang, Xiaomei Peng, Jing Zheng, Yong Wu, Jianda Hu
This study aimed to analyse the characteristics and treatment outcomes of adult patients with acute lymphoblastic leukaemia (ALL) and construct nomogram predictive models for prognosis prediction. Between January 2017 and June 2022, 462 adult patients with ALL were included in this retrospective analysis. Patients' ages ranged from 14 to 84 years. B-cell origin was observed in 82.7% of these patients, while 17.3% of the cases were of T-cell origin. The BCR/ABL1 fusion gene was detected in 32.9% of those with B-ALL...
March 14, 2024: Annals of Hematology
https://read.qxmd.com/read/38469143/tyrosine-kinase-inhibitors-in-patients-with-advanced-anaplastic-thyroid-cancer-an-effective-analysis-based-on-real-world-retrospective-studies
#6
Bo-Hua Kuang, Wen-Xuan Zhang, Guo-He Lin, Chen Fu, Ru-Bo Cao, Bi-Cheng Wang
BACKGROUND: Tyrosine kinase inhibitors (TKIs) contribute to the treatment of patients with anaplastic thyroid cancer (ATC). Although prospective clinical studies of TKIs exhibit limited efficacy, whether ATC patients benefit from TKI treatment in real-world clinical practice may enlighten future explorations. Therefore, we conducted this effective analysis based on real-world retrospective studies to illustrate the efficacy of TKI treatment in ATC patients. METHODS: We systematically searched the online databases on September 03, 2023...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38468266/comparative-effectiveness-of-implementation-strategies-for-accelerating-cervical-cancer-elimination-through-the-integration-of-screen-and-treat-services-access-study-protocol-for-a-cluster-randomized-hybrid-type-iii-trial-in-nigeria
#7
JOURNAL ARTICLE
Babayemi O Olakunde, Ijeoma U Itanyi, John O Olawepo, Lin Liu, Chinenye Bembir, Ngozi Idemili-Aronu, Nwamaka N Lasebikan, Tonia C Onyeka, Cyril C Dim, Chibuike O Chigbu, Echezona E Ezeanolue, Gregory A Aarons
BACKGROUND: Despite the increased risk of cervical cancer (CC) among women living with HIV (WLHIV), CC screening and treatment (CCST) rates remain low in Africa. The integration of CCST services into established HIV programs in Africa can improve CC prevention and control. However, the paucity of evidence on effective implementation strategies (IS) has limited the success of integration in many countries. In this study, we seek to identify effective IS to enhance the integration of CCST services into existing HIV programs in Nigeria...
March 11, 2024: Implementation Science: IS
https://read.qxmd.com/read/38467310/systematic-review-of-tailored-dietary-advice-and-dietitian-involvement-in-the-treatment-of-chronic-obstructive-pulmonary-disease-copd
#8
REVIEW
Kylie Bell, Josh Lawson, Erika Penz, Allison Cammer
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading public health concern globally. Interdisciplinary pulmonary rehabilitation programs exist and should ideally consider nutritional health impacts since the nutritional status of COPD patients is often compromised. However, little is known about the role of dietary counseling in COPD management. RESEARCH QUESTION: Does providing tailored dietary advice to adult patients with COPD improve outcomes? STUDY DESIGN AND METHODS: We conducted a systematic review...
March 9, 2024: Respiratory Medicine
https://read.qxmd.com/read/38466642/cop9-signalosome-complex-is-a-prognostic-biomarker-and-corresponds-with-immune-infiltration-in-hepatocellular-carcinoma
#9
JOURNAL ARTICLE
Jiahui Liu, Dexing Han, Junfeng Xuan, Jinye Xie, Weijia Wang, Quan Zhou, Kang Chen
Hepatocellular carcinoma (HCC) is among the most common deadly tumors but still lacks specific biomarkers for diagnosis, prognosis, and treatment guidance. The COP9 signalosome (COPS) is an essential regulator of the ubiquitin conjugation pathway upregulated in various cancers. We evaluated the contributions of COPS subunits to HCC tumorigenesis and their utility for prognosis. We comprehensively evaluated the tumor expression pattern and tumorigenic functions of COPS subunits using The Cancer Genome Atlas (TCGA), The Human Protein Atlas and immunohistochemistry...
March 11, 2024: Aging
https://read.qxmd.com/read/38466483/a-programmed-cell-death-related-gene-signature-to-predict-prognosis-and-therapeutic-responses-in-liver-hepatocellular-carcinoma
#10
JOURNAL ARTICLE
Xinyu Gu, Jie Pan, Yanle Li, Liushun Feng
BACKGROUND: Programmed cell death (PCD) functions critically in cancers and PCD-related genes are associated with tumor microenvironment (TME), prognosis and therapeutic responses of cancer patients. This study stratified hepatocellular carcinoma (HCC) patients and develop a prognostic model for predicting prognosis and therapeutic responses. METHODS: Consensus clustering analysis was performed to subtype HCC patients in The Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) among the subtypes were filtered and subjected to the least absolute shrinkage and selection operator (LASSO) regression analysis and univariate Cox regression analysis to filter prognostic genes...
March 11, 2024: Discover. Oncology
https://read.qxmd.com/read/38463550/the-economic-burden-of-the-covid-19-pandemic-in-state-of-kuwait
#11
JOURNAL ARTICLE
Amrizal Muhammad Nur, Syed Mohamed Aljunid, Mohammad Almari
PURPOSE: The main aim of this study is to estimate the provider's cost, patients' cost (home and institutional quarantine cost) and the total economic burden of COVID-19 for patients with PCR positive in Kuwait. PATIENTS AND METHODS: This cross-sectional and retrospective study identified the cost incurred for treating COVID-19 inpatients admitted to a General Hospital in Kuwait, a designated COVID-19 treatment center by the Kuwait Government during pandemic. A total of 485 COVID-19 patients were randomly selected from May 1st to September 31st, 2021...
2024: ClinicoEconomics and Outcomes Research: CEOR
https://read.qxmd.com/read/38458802/incidence-contributing-factors-and-outcomes-of-birth-injury-among-newborns-in-africa-a-systematic-review-of-quantitative-evidence-protocol
#12
JOURNAL ARTICLE
Abera Mersha, Shitaye Shibiru
INTRODUCTION: Birth injury is a significant public health problem in Africa, with a high incidence and associated mortality and morbidity. Systematic reviews that indicate the incidence, contributing factors and outcomes of birth injury in Africa provide valuable evidence to policy-makers and programme planners for improving prevention and treatment strategies. Therefore, this review is aimed to evaluate the incidence, contributing factors and outcomes of birth injury among newborns in Africa...
March 8, 2024: BMJ Open
https://read.qxmd.com/read/38458563/critical-comments-by-fda-reviewers-on-patient-reported-outcomes-in-fda-regulatory-submissions-2018-2021
#13
JOURNAL ARTICLE
Christina Slota, Lindsey Norcross, Erin Comerford, Medha Sasane, Ying Zheng, Ari Gnanasakthy
OBJECTIVES: This manuscript examines the inclusion of patient-reported outcome (PRO) data in new drug applications (NDAs) submitted to the Food and Drug Administration (FDA) and approved from 2018 through 2021. The importance of assessing PROs, which capture patients' perspectives on the disease and treatment experience, has been underscored by many stakeholders, including regulatory authorities. Despite the increasing inclusion of PRO assessments in registration trials, inclusion of language related to PRO results in approved product labeling varies widely...
March 6, 2024: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://read.qxmd.com/read/38457589/comparison-of-different-interventions-for-the-reduction-of-labor-pain-a-systematic-review-and-network-meta-analysis
#14
JOURNAL ARTICLE
Mengxian Yu, Haiyan Qian, Miao Gan
OBJECTIVE: This systematic review and network meta-analysis were performed to compare different interventions for the reduction of labor pain. METHODS: PubMed, Embase, Cochrane Library, Web of Science and ScienceDirect databases were searched for the randomized controlled trials (RCTs) meeting prespecified inclusion criteria up to January, 2023. Interventions including electrical acupoint stimulation (TEAS), epidural analgesia (EA) and control treatments. The primary outcomes included pain scores, failure rate of natural delivery, adverse events and Apgar scores...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38449910/testing-an-implementation-package-in-a-housing-skills-training-pilot-for-homeless-experienced-persons-with-serious-mental-illness
#15
JOURNAL ARTICLE
Sonya Gabrielian, Alison B Hamilton, Lillian Gelberg, Ella R Koosis, Lauren Hoffmann, David M Carlson, Alexander S Young
BACKGROUND: Evidence-based practices (EBPs) improve housing and health for persons who have experienced homelessness with serious mental illness (PEH-SMI) but are challenging to implement. We tested a strategy to support pilot implementation of a 12-session housing skills training intervention for PEH-SMI, tailored from effective social skills training interventions. We aimed to optimize the implementation strategy and intervention prior to an implementation trial. METHOD: We provided training and technical assistance to nine providers to support pilot implementation of this intervention to six groups of PEH-SMI ( n  = 35) engaged in VA Greater Los Angeles' homeless services...
2024: Implementation research and practice
https://read.qxmd.com/read/38446349/increase-in-acute-pancreatitis-especially-gallstone-related-as-the-cause-for-emergency-admissions-temporal-trend-from-kashmir-india
#16
JOURNAL ARTICLE
Shaheena Parveen, Jaswinder Singh Sodhi, Neeraj Dhar, Shaheen Nazir, Ankush Sharma, Tariq Abdullah Mir, Kalpana Acharya, Mushtaq Ahmed Khan, Ghulam Mohd Gulzar, Altaf Hussain Shah, Ghulam Nabi Yattoo, Kuldeep S Raina
BACKGROUND: The incidence of acute pancreatitis is increasing globally. Gallstones (GS) and ascariasis are the major causes for acute pancreatitis in the Kashmiri population. In recent years, we have observed an increase in the admission rate of acute pancreatitis. Many patients who present first time as gallstone pancreatitis have asymptomatic gallstones. We aimed at studying the etiology and yearly admission rate of acute pancreatitis with main focus on gallstone pancreatitis and the contribution of asymptomatic gallstones...
March 6, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/38444059/the-impact-of-glucocorticoids-therapy-on-cutaneous-wounds-in-kawasaki-disease-a-meta-analysis-of-randomized-controlled-trials
#17
REVIEW
Jian Hu, Lichao Gao, Songling Fu, Wei Wang, Chunhong Xie, Yiying Zhang, Haiyan Ke, Fangqi Gong
Kawasaki disease (KD) is one of the most challenging diseases that is defined as an acute vasculitis that affects the coronary arteries primarily in children. It causes complications if left untreated at early stages, ultimately leading to death. Corticosteroids have been recognized to treat and cause great impact on the patients with KD. Glucocorticoid is one of the main corticosteroids that are being used to treat KD and cutaneous wounds. However, ineffectiveness of a few glucocorticoids can limit the efficacy of this treatment...
March 2024: International Wound Journal
https://read.qxmd.com/read/38431501/clinical-application-of-an-institutional-fractionated-stereotactic-radiosurgery-fsrs-program-for-brain-metastases-delivered-with-mridian-%C3%A2-braintx%C3%A2
#18
Alonso La Rosa, Kathryn E Mittauer, Nema Bassiri, D Jay J Wieczorek, Yongsook C Lee, Amy E Rzepczynski, Michael D Chuong, Tugce Kutuk, Nicole C McAllister, Matthew D Hall, Alonso N Gutierrez, Ranjini Tolakanahalli, Minesh P Mehta, Rupesh Kotecha
Single-fraction stereotactic radiosurgery (SRS) or fractionated SRS (FSRS) are well established strategies for patients with limited brain metastases. A broad spectrum of modern dedicated platforms are currently available for delivering intracranial SRS/FSRS; however, SRS/FSRS delivered using traditional CT-based platforms relies on the need for diagnostic MR images to be coregistered to planning CT scans for target volume delineation. Additionally, the on-board image guidance on traditional platforms yields limited inter-fraction and intra-fraction real-time visualization of the tumor at the time of treatment delivery...
March 1, 2024: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://read.qxmd.com/read/38423028/a-preoperative-package-of-care-for-osteoarthritis-consisting-of-weight-loss-orthotics-rehabilitation-and-topical-and-oral-analgesia-opportunity-a-two-centre-open-label-randomised-controlled-feasibility-trial
#19
JOURNAL ARTICLE
A Hamish R W Simpson, Nicholas D Clement, Sharon A Simpson, Hemandt Pandit, Susie Smillie, Anthony R Leeds, Philip G Conaghan, Sarah R Kingsbury, David Hamilton, Peter Craig, David Ray, Catriona Keerie, Elaine Kinsella, Anna Bell-Higgs, Arlene McGarty, Christine Beadle, Colin R Howie, John Norrie
BACKGROUND: Osteoarthritis of the knee is a major cause of disability worldwide. Non-operative treatments can reduce the morbidity but adherence is poor. We hypothesised that adherence could be optimised if behavioural change was established in the preoperative period. Therefore, we aimed to assess feasibility, acceptability, and recruitment and retention rates of a preoperative package of non-operative care in patients awaiting knee replacement surgery. METHODS: We did an open-label, randomised controlled, feasibility trial in two secondary care centres in the UK...
February 26, 2024: Lancet Rheumatology
https://read.qxmd.com/read/38422830/treatment-package-time%C3%A2-%C3%A2-14%C3%A2-weeks-improves-recurrence-free-and-disease-specific-survival-in-hpv-positive-opc-with-high-risk-features
#20
JOURNAL ARTICLE
Manasa Melachuri, Chareeni Kurukulasuriya, Purva Rumde, Terral Patel, Daniel Awad, Seungwon Kim, Robert Ferris, Shaum Sridharan, Umamaheswar Duvvuri
BACKGROUND: Guidelines recommend treatment package time < 85 days and time from surgery to radiation initiation < 6 weeks in head and neck cancer patients. However, HPV positive primaries treated with TORS and adjuvant radiotherapy traditionally demonstrate favorable outcomes. METHODS: Single center retrospective chart review of patients diagnosed with HPV positive treatment naïve primary squamous cell carcinoma treated with TORS and postoperative radiation therapy with or without Chemotherapy from 2012 to 2022 with data collection from December 2022-April 2023...
February 28, 2024: Oral Oncology
keyword
keyword
119328
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.