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https://www.readbyqxmd.com/read/27904561/analysis-of-outcomes-and-prognostic-factors-of-acute-lymphoblastic-leukemia-patients-treated-by-mcp841-protocol-a-regional-cancer-center-experience
#1
Akhil Kapoor, Ashok Kalwar, Narender Kumar, Mukesh Kumar Singhal, Surender Beniwal, Harvindra Singh Kumar
BACKGROUND: A dramatic improvement in the survival of acute lymphoblastic leukemia (ALL) patients in the last three decades has been observed. MCP 841 protocol is an old but effective tool with tolerable toxicities. The objective of this study was to estimate the relapse-free survival of ALL patients treated uniformly with MCP 841 protocol on the basis of various prognostic factors. MATERIALS AND METHODS: The study design was retrospective and it was conducted in a regional cancer center of Northwest India...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27899073/recommendations-for-the-analysis-of-individually-randomised-controlled-trials-with-clustering-in-one-arm-a-case-of-continuous-outcomes
#2
Laura Flight, Annabel Allison, Munyaradzi Dimairo, Ellen Lee, Laura Mandefield, Stephen J Walters
BACKGROUND: In an individually randomised controlled trial where the treatment is delivered by a health professional it seems likely that the effectiveness of the treatment, independent of any treatment effect, could depend on the skill, training or even enthusiasm of the health professional delivering it. This may then lead to a potential clustering of the outcomes for patients treated by the same health professional, but similar clustering may not occur in the control arm. Using four case studies, we aim to provide practical guidance and recommendations for the analysis of trials with some element of clustering in one arm...
November 29, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27884217/from-neurocognition-to-community-participation-in-serious-mental-illness-the-intermediary-role-of-dysfunctional-attitudes-and-motivation
#3
E C Thomas, L Luther, L Zullo, A T Beck, P M Grant
BACKGROUND: Evidence for a relationship between neurocognition and functional outcome in important areas of community living is robust in serious mental illness research. Dysfunctional attitudes (defeatist performance beliefs and asocial beliefs) have been identified as intervening variables in this causal chain. This study seeks to expand upon previous research by longitudinally testing the link between neurocognition and community participation (i.e. time in community-based activity) through dysfunctional attitudes and motivation...
November 25, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27858080/-treatment-of-mandibular-angle-fracture-through-intraoral-and-extraoral-approach-a-comparative-study
#4
Bo-Jun Zhang, Wei-Hong Wang, Biao Xu
PURPOSE: To compare the clinical effects of mandibular angle fracture surgery through intraoral and extraoral approach. METHODS: From January 2008 to December 2014, 46 patients with mandibular angle fracture were retrospectively recruited in this study. An intraoral approach was used in 22 cases as group 1 in whom the fractures were fixed by one titanium miniplate alone, the others through an extraoral approach as group 2 in whom the fractures were fixed by two plates...
August 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/27846070/implementation-and-operational-research-an-integrated-and-comprehensive-service-delivery-model-to-improve-pediatric-and-maternal-hiv-care-in-rural-africa
#5
Anna Gamell, Tracy R Glass, Lameck B Luwanda, Herry Mapesi, Leila Samson, Tom Mtoi, Angelo Nyamtema, Lukas Muri, Alex Ntamatungiro, Marcel Tanner, Christoph Hatz, Manuel Battegay, Emilio Letang
BACKGROUND: Strategies to improve HIV diagnosis and linkage into care, antiretroviral treatment coverage, and treatment outcomes of mothers and children are urgently needed in sub-Saharan Africa. METHODS: From December 2012, we implemented an intervention package to improve prevention of mother-to-child transmission (PMTCT) and pediatric HIV care in our rural Tanzanian clinic, consisting of: (1) creation of a PMTCT and pediatric unit integrated within the reproductive and child health clinic; (2) implementation of electronic medical records; (3) provider-initiated HIV testing and counseling in the hospital wards; and (4) early infant diagnosis test performed locally...
December 15, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27842706/insomnia-from-drug-treatments-evidence-from-meta-analyses-of-randomized-trials-and-concordance-with-prescribing-information
#6
Anthony G Doufas, Orestis A Panagiotou, Periklis Panousis, Shane Shucheng Wong, John P A Ioannidis
OBJECTIVE: To determine whether drugs used to treat diverse conditions cause insomnia symptoms and whether their prescription information is concordant with this evidence. METHODS: We conducted a survey of meta-analyses (Cochrane Database of Systematic Reviews) and comparisons with package inserts compiled in the Physicians' Desk Reference (PDR). We identified randomized controlled trials (RCTs) in which any drug had been evaluated vs placebo and sleep had been assessed...
November 11, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27836513/anticoagulant-therapy-for-symptomatic-calf-deep-vein-thrombosis-cactus-a-randomised-double-blind-placebo-controlled-trial
#7
Marc Righini, Jean-Philippe Galanaud, Hervé Guenneguez, Dominique Brisot, Antoine Diard, Pascale Faisse, Marie-Thérèse Barrellier, Claudine Hamel-Desnos, Christine Jurus, Olivier Pichot, Myriam Martin, Lucia Mazzolai, Clarisse Choquenet, Sandrine Accassat, Helia Robert-Ebadi, Marc Carrier, Grégoire Le Gal, Bernadette Mermilllod, Jean-Pierre Laroche, Henri Bounameaux, Arnaud Perrier, Susan R Kahn, Isabelle Quere
BACKGROUND: The efficacy and safety of anticoagulant treatment is not established for patients with acute symptomatic deep vein thrombosis (DVT) of the calf. We aimed to assess whether therapeutic anticoagulation is superior to placebo in patients with symptomatic calf DVT. METHODS: In this randomised, double-blind, placebo-controlled trial, we enrolled low-risk outpatients (without active cancer or previous venous thromboembolic disease) with a first acute symptomatic DVT in the calf from 23 university medical centres or community medical clinics in Canada, France, and Switzerland...
November 7, 2016: Lancet Haematology
https://www.readbyqxmd.com/read/27825368/impact-of-laryngopharyngeal-reflux-on-subjective-and-objective-voice-assessments-a-prospective-study
#8
Jérôme R Lechien, Kathy Huet, Mohamad Khalife, Anne-Françoise Fourneau, Véronique Delvaux, Myriam Piccaluga, Bernard Harmegnies, Sven Saussez
BACKGROUND: Laryngopharyngeal reflux is a prevalent, not well-understood disease affecting a high proportion of patients who seek laryngology consultation. The objective of this prospective case series is to explore the subjective and objective voice modifications in Laryngopharyngeal reflux (LPR), especially the usefulness of acoustic parameters as treatment outcomes, and to better understand the pathophysiological mechanisms underlying the development of voice disorder. METHODS: Forty-one patients with a reflux finding score (RFS) > 7 and a reflux symptom index (RSI) > 13 were enrolled and treated with pantoprazole 20 mg twice daily for three months...
November 8, 2016: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27812403/the-impact-of-il-6-and-il-28b-gene-polymorphisms-on-treatment-outcome-of-chronic-hepatitis-c-infection-among-intravenous-drug-users-in-croatia
#9
Zoran Bogdanović, Ivana Marinović-Terzić, Sendi Kuret, Ana Jerončić, Nikola Bradarić, Gea Forempoher, Ozren Polašek, Šimun Anđelinović, Janoš Terzić
BACKGROUND: Several genes and their single nucleotide polymorphisms (SNPs) are associated with either spontaneous resolution of hepatitis C infection or better treatment-induced viral clearance. We tested a cohort of intravenous drug users (IVDU) diagnosed with chronic hepatitis C virus (HCV) for treatment response and its association with the SNPs in the interleukin-6 (rs1800795-IL6) and the interleukin-28B (rs12979860-IL28B) genes. METHODS: The study included 110 Croatian IVDU positive for anti-HCV antibody...
2016: PeerJ
https://www.readbyqxmd.com/read/27802300/amplitude-integrated-electroencephalogram-as-a-prognostic-tool-in-neonates-with-hypoxic-ischemic-encephalopathy-a-systematic-review
#10
Ruth Del Río, Carlos Ochoa, Ana Alarcon, Juan Arnáez, Dorotea Blanco, Alfredo García-Alix
INTRODUCTION: Perinatal management and prognostic value of clinical evaluation and diagnostic tools have changed with the generalization of therapeutic hypothermia (TH) in infants with hypoxic-ischemic encephalopathy (HIE). AIM: to ascertain the prognostic value of amplitude integrated electroencephalogram (aEEG) in neonates with HIE considering hours of life and treatment with TH. METHODS: A systematic review was performed. Inclusion criteria were studies including data of neonates with HIE, treated or not with TH, monitored with aEEG and with neurodevelopmental follow-up of at least 12 months...
2016: PloS One
https://www.readbyqxmd.com/read/27790585/clinical-and-radiologic-evaluation-of-regenerative-potential-of-nha-paste-and-dbm-in-the-treatment-of-periodontal-intra-bony-defects-a-randomized-control-trial
#11
Deepti Jain, Anshul Sawhney, Bharat Gupta, Saurabh Sharma, Saurabh Juneja, Manjushree Juneja, Shruti Sharma, Neha Patil
INTRODUCTION: Previous studies have shown that Hydroxyapatite (HA) has shown good results in the treatment of intra-osseous periodontal defects. A newer variety of HA has been designed over a period of research which has nano-sized particles and is availed in a paste consistency called Nanocrystalline Hydroxyapatite paste (NHA paste). This variation in size and surface area of NHA paste can provide better results when used in intra-bony defects. AIM: The purpose of this study was to compare the clinical and radiographic outcomes obtained with usage of NHA paste to those obtained with Demineralized Bone Matrix (DBM) in the treatment of periodontal intra-bony defects...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27784997/expectation-and-satisfaction-of-hiv-aids-patients-toward-the-pharmaceutical-care-provided-at-gondar-university-referral-hospital-northwestern-ethiopia-a-cross-sectional-study
#12
Tamrat Befekadu Abebe, Daniel Asfaw Erku, Begashaw Melaku Gebresillassie, Kaleab Taye Haile, Abebe Basazn Mekuria
PURPOSE: Measurements of patient satisfaction help to assess the performance of health service provision and predict treatment adherence and outcomes. This study aimed to assess human HIV/AIDS patients' expectation of and satisfaction with the pharmaceutical service delivered at Gondar University Referral Hospital, Ethiopia. PATIENTS AND METHODS: An institution-based cross-sectional study was performed from May 11 to 25, 2015. A total of 291 patients living with HIV/AIDS were included using a simple random sampling method...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27770820/a-randomised-controlled-trial-of-the-clinical-and-cost-effectiveness-of-a-contingency-management-intervention-compared-to-treatment-as-usual-for-reduction-of-cannabis-use-and-of-relapse-in-early-psychosis-circle-a-study-protocol-for-a-randomised-controlled
#13
Sonia Johnson, Luke Sheridan Rains, Steven Marwaha, John Strang, Thomas Craig, Tim Weaver, Paul McCrone, Michael King, David Fowler, Stephen Pilling, Louise Marston, Rumana Z Omar, Meghan Craig, Mark Hinton
BACKGROUND: Around 35-45 % of people in contact with services for a first episode of psychosis are using cannabis. Cannabis use is associated with delays in remission, poorer clinical outcomes, significant increases in the risk of relapse, and lower engagement in work or education. While there is a clear need for effective interventions, so far only very limited benefits have been achieved from psychological interventions. Contingency management (CM) is a behavioural intervention in which specified desired behavioural change is reinforced through financial rewards...
October 22, 2016: Trials
https://www.readbyqxmd.com/read/27754539/trends-in-tuberculosis-notification-and-treatment-outcomes-in-prisons-a-country-wide-assessment-in-el-salvador-from-2009-2014
#14
Gilberto Ayala, Julio Garay, Miguel Aragon, Tom Decroo, Rony Zachariah
Objective To describe trends in tuberculosis (TB) notification and treatment outcomes in 25 prisons in El Salvador from 2009-2014 and to determine if a set of interventions introduced in 2011 affected TB case finding and management. Methods This was operational research that utilized a retrospective cohort study of program data from 2009-2014. The package of interventions introduced in 2011 provides staff training, engages inmates in TB case finding, and offers diagnosis through mobile X-ray and Xpert® MTB/RIF...
January 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/27754282/hw-04-3-global-network-for-her-based-big-data-analysis
#15
Peter Rijnbeek
Massive numbers of electronic health records are currently being collected globally, including structured data in the form of diagnoses, medications, laboratory test results, and unstructured data contained in clinical narratives. This opens unprecedented possibilities for research and ultimately patient care. However, actual use of these databases in a multi-center study is severely hampered by a variety of challenges, e.g., each database has a different database structure and uses different terminology systems...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27730085/women-in-india-with-gestational-diabetes-mellitus-strategy-wings-methodology-and-development-of-model-of-care-for-gestational-diabetes-mellitus-wings-4
#16
Arivudainambi Kayal, Viswanathan Mohan, Belma Malanda, Ranjit Mohan Anjana, Balaji Bhavadharini, Manni Mohanraj Mahalakshmi, Kumar Maheswari, Ram Uma, Ranjit Unnikrishnan, Gunasekaran Kalaiyarasi, Lyudmil Ninov, Anne Belton
AIM: The Women In India with GDM Strategy (WINGS) project was conducted with the aim of developing a model of care (MOC) suitable for women with gestational diabetes mellitus (GDM) in low- and middle-income countries. METHODOLOGY: The WINGS project was carried out in Chennai, Southern India, in two phases. In Phase I, a situational analysis was conducted to understand the practice patterns of health-care professionals and to determine the best screening criteria through a pilot screening study...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27707828/fracture-in-the-elderly-multidisciplinary-rehabilitation-femur-a-phase-ii-randomised-feasibility-study-of-a-multidisciplinary-rehabilitation-package-following-hip-fracture
#17
Nefyn H Williams, Jessica L Roberts, Nafees Ud Din, Nicola Totton, Joanna M Charles, Claire A Hawkes, Val Morrison, Zoe Hoare, Michelle Williams, Aaron W Pritchard, Swapna Alexander, Andrew Lemmey, Robert T Woods, Catherine Sackley, Pip Logan, Rhiannon T Edwards, Clare Wilkinson
OBJECTIVE: To conduct a rigorous feasibility study for a future definitive parallel-group randomised controlled trial (RCT) and economic evaluation of an enhanced rehabilitation package for hip fracture. SETTING: Recruitment from 3 acute hospitals in North Wales. Intervention delivery in the community. PARTICIPANTS: Older adults (aged ≥65) who received surgical treatment for hip fracture, lived independently prior to fracture, had mental capacity (assessed by clinical team) and received rehabilitation in the North Wales area...
October 5, 2016: BMJ Open
https://www.readbyqxmd.com/read/27704529/an-adaptive-mantel-haenszel-test-for-sensitivity-analysis-in-observational-studies
#18
Paul R Rosenbaum, Dylan S Small
In a sensitivity analysis in an observational study with a binary outcome, is it better to use all of the data or to focus on subgroups that are expected to experience the largest treatment effects? The answer depends on features of the data that may be difficult to anticipate, a trade-off between unknown effect-sizes and known sample sizes. We propose a sensitivity analysis for an adaptive test similar to the Mantel-Haenszel test. The adaptive test performs two highly correlated analyses, one focused analysis using a subgroup, one combined analysis using all of the data, correcting for multiple testing using the joint distribution of the two test statistics...
October 4, 2016: Biometrics
https://www.readbyqxmd.com/read/27697869/improving-the-well-being-of-men-by-evaluating-and-addressing-the-gastrointestinal-late-effects-eagle-of-radical-treatment-for-prostate-cancer-study-protocol-for-a-mixed-method-implementation-project
#19
Sophia Taylor, Weyinmi Demeyin, Ann Muls, Catherine Ferguson, Damian J J Farnell, David Cohen, Jervoise Andreyev, John Green, Lesley Smith, Sam Ahmedzai, Sara Pickett, Annmarie Nelson, John Staffurth
INTRODUCTION: Radiotherapy treatment for prostate cancer can cause bowel problems, which may lead to severe difficulties for cancer survivors including limiting travel, work or socialising. These symptoms can appear at any time following radiotherapy. This study focuses on the early identification and protocol-based management of effects known to cause long-term, or even permanent, changes to the well-being of prostate cancer survivors. The rationale of this study is to improve the care offered to men and their families following pelvic radiotherapy for prostate cancer...
October 3, 2016: BMJ Open
https://www.readbyqxmd.com/read/27656512/a-clinical-experience-of-ectopic-pregnancies-with-initial-free-intraperitoneal-fluid
#20
Mehmet Akif Sargin, Murat Yassa, Bilge Dogan Taymur, Ayhan Çelik, Sibel Aydin, Emrah Orhan, Niyazi Tug
INTRODUCTION: Extra-uterine pregnancy or Ectopic Pregnancy (EP) is a major health problem for pregnant women, presenting as a potentially life-threatening emergency in the first trimester. There are three major options for the treatment of EP: expectant management, surgical treatment and medical management. The presence of free intraperitoneal fluid in EP-diagnosed patients is crucial for treatment planning and evaluation. AIM: To compare the outcomes of both the expectant man-agement and medical treatment with methotrexate (MTX) in ectopic pregnancies with free intraperitoneal fluid...
August 2016: Journal of Clinical and Diagnostic Research: JCDR
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