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https://www.readbyqxmd.com/read/29907335/trial-protocol-the-use-of-mindfulness-based-intervention-for-improving-bracing-compliance-for-adolescent-idiopathic-scoliosis-patients-protocol-for-a-randomised-controlled-trial
#1
Benjamin Hon Kei Yip, Xue Li, Christine Hiu Yan Leung, Ting Gao, Vincent Chi Ho Chung, Fiona Wai Ping Yu, Tsz Ping Lam, Jack Chun Yiu Cheng, Samuel Yeung Shan Wong
INTRODUCTION: Adolescent idiopathic scoliosis (AIS) is the most prevalent deforming orthopaedic condition; it causes significant disability when spinal curves progress beyond 45deg. Bracing is the primary treatment prescribed for adolescents with an immature skeleton who have spinal curves between 25 and 45deg. New evidence suggests that compliance with bracing significantly decreases the progression of high-risk curves to the threshold for surgery. Nonetheless, bracing is a stressful experience...
June 12, 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29905543/importance-of-isolated-gestational-hypothyroxinemia-in-the-development-of-obstetric-and-somatic-pathologies
#2
N Morchiladze, B Tkeshelashvili, T Gagua, D Gagua
The isolated hypothyroxinemia of pregnancy (IHP) has gained specific attention in the specialized literature during the recent years as the possible factor impeding the intellectual development of fetus and increasing the risk of complications related with pregnancy, delivery and perinatal period. Aim of the study was to define the importance of isolated hypothyroxinemia in the development of obstetric and somatic pathologies in outpatient population of pregnant females. The study of prospective design was performed at the base of "David Gagua Clinic" Ltd...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29869589/generalized-causal-mediation-and-path-analysis-extensions-and-practical-considerations
#3
Jeffrey M Albert, Jang Ik Cho, Yiying Liu, Suchitra Nelson
Causal mediation analysis seeks to decompose the effect of a treatment or exposure among multiple possible paths and provide casually interpretable path-specific effect estimates. Recent advances have extended causal mediation analysis to situations with a sequence of mediators or multiple contemporaneous mediators. However, available methods still have limitations, and computational and other challenges remain. The present paper provides an extended causal mediation and path analysis methodology. The new method, implemented in the new R package, gmediation (described in a companion paper), accommodates both a sequence (two stages) of mediators and multiple mediators at each stage, and allows for multiple types of outcomes following generalized linear models...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29866192/adherence-to-treatment-with-artemether-lumefantrine-or-amodiaquine-artesunate-for-uncomplicated-malaria-in-children-in-sierra-leone-a-randomized-trial
#4
Kristin Banek, Emily L Webb, Samuel Juana Smith, Daniel Chandramohan, Sarah G Staedke
BACKGROUND: Prompt, effective treatment of confirmed malaria cases with artemisinin-based combination therapy (ACT) is a cornerstone of malaria control. Maximizing adherence to ACT medicines is key to ensuring treatment effectiveness. METHODS: This open-label, randomized trial evaluated caregiver adherence to co-formulated artemether-lumefantrine (AL) and fixed-dose amodiaquine-artesunate (AQAS) in Sierra Leone. Children aged 6-59 months diagnosed with malaria were recruited from two public clinics, randomized to receive AL or AQAS, and visited at home the day after completing treatment...
June 4, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29850860/pathway-structured-predictive-modeling-for-multi-level-drug-response-in-multiple-myeloma
#5
Xinyan Zhang, Bingzong Li, Huiying Han, Sha Song, Hongxia Xu, Zixuan Yi, Yating Hong, Wenzhuo Zhuang, Nengjun Yi
Motivation: Molecular analyses suggest that myeloma is composed of distinct subtypes that have different molecular pathologies and various response rates to certain treatments. Drug responses in multiple myeloma (MM) are usually recorded as a multi-level ordinal outcome. One of the goals of drug response studies is to predict which response category any patients belong to with high probability based on their clinical and molecular features. However, as most of genes have small effects, gene-based models may provide limited predictive accuracy...
May 29, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29805480/systemic-bioinformatics-analysis-of-skeletal-muscle-gene-expression-profiles-of-sepsis
#6
Fang Yang, Yumei Wang
Sepsis is a type of systemic inflammatory response syndrome with high morbidity and mortality. Skeletal muscle dysfunction is one of the major complications of sepsis that may also influence the outcome of sepsis. The aim of the present study was to explore and identify potential mechanisms and therapeutic targets of sepsis. Systemic bioinformatics analysis of skeletal muscle gene expression profiles from the Gene Expression Omnibus was performed. Differentially expressed genes (DEGs) in samples from patients with sepsis and control samples were screened out using the limma package...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29798947/nasopharyngeal-carcinoma-experience-and-treatment-outcome-with-radical-conformal-radiotherapy-from-a-tertiary-care-center-in-india
#7
Beena Kunheri, Gunjan Agarwal, P S Sunil, Anoop Ramesan Nair, K U Pushpaja
BACKGROUND AND AIM: The majority of nasopharyngeal carcinoma (NPC) reports on the outcome and prognostic factors are from endemic high-risk regions. Data on the outcome of Indian patients are sparse. In this study, we retrospectively analyzed the outcome of NPC patients treated radically with conformal radiotherapy (RT). The primary objective was to assess the outcome, and the secondary objectives were to assess treatment-related morbidities and the impact of various prognostic factors on the outcome...
July 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29785254/low-rates-of-patient-reported-outcome-claims-for-orphan-drugs-approved-by-the-us-food-and-drug-administration
#8
Szymon Jarosławski, Pascal Auquier, Borislav Borissov, Claude Dussart, Mondher Toumi
Background : Claims included in package inserts (PIs) for medicinal products approved by the US Food and Drug Administration (FDA) constitute the regulatory definition of drugs' benefits and risks. Objective : We sought to assess the usage of patient-reported outcome (PRO) claims in a comprehensive set of US FDA orphan drug approvals dated between 1/1/2012 and 31/12/2016, and characterize them. Study design : Orphan drug approval documentation was obtained from the US FDA website. Drug Package Inserts (PI) were analyzed to extract information on PRO-related language...
2018: Journal of Market Access & Health Policy
https://www.readbyqxmd.com/read/29776708/predictors-of-treatment-outcome-for-the-unified-protocol-for-transdiagnostic-treatment-of-emotional-disorders-in-children-up-c
#9
Sarah M Kennedy, Niza A Tonarely, Jamie A Sherman, Jill Ehrenreich-May
Various efficacious treatment packages exist for youth anxiety, and cognitive behavior therapy (CBT) is now considered to be a well-established treatment for child anxiety disorders (Higa-McMillan, Francis, Rith-Najarian, & Chorpita, 2016). Improving outcomes for the significant proportion of anxious youth who demonstrate inadequate response to CBT is imperative, but our understanding of who does and does not benefit is incomplete. Further, there are no known empirical studies of predictors of treatment response for youth who receive a transdiagnostic intervention for anxiety or depression, and it is therefore unclear whether predictors of response to a transdiagnostic treatment for children are similar to those found in previous studies of anxiety-specific treatments...
May 15, 2018: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29773516/lymphoedema-management-to-prevent-acute-dermatolymphangioadenitis-in-podoconiosis-in-northern-ethiopia-golbet-a-pragmatic-randomised-controlled-trial
#10
Henok Negussie, Meseret Molla, Moses Ngari, James A Berkley, Esther Kivaya, Patricia Njuguna, Greg Fegan, Abreham Tamiru, Abebe Kelemework, Trudie Lang, Melanie J Newport, Andy McKay, Fikre Enquoselassie, Gail Davey
BACKGROUND: Podoconiosis (also known as endemic, non-filarial elephantiasis) affects about 4 million subsistence farmers in tropical Africa. Poor awareness of the condition and inadequate evidence for the efficacy of treatment mean that no government in an endemic country yet offers lymphoedema management for patients with podoconiosis. Among patients with filarial lymphoedema, trials suggest that limb care is effective in reducing the most disabling sequelae: episodes of acute dermatolymphangioadenitis...
May 14, 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29764784/sneezing-and-perilymphatic-fistula-of-the-round-window-case-report-and-systematic-review-of-the-literature
#11
Francesco Comacchio, Marta Mion
The goal of the present study was to describe a case of perilymphatic fistula (PLF) of the round window (RW) that occurred after sneezing, along with a review of the literature. We report a case of PLF of RW, which was provoked by sneezing, and its consequent medical and surgical treatments. With respect to the review of the literature, articles were initially selected based on their titles or abstracts, followed by methodological evaluation. The patient underwent an explorative tympanotomy (ET) with packaging of RW with the pericondrium, following which the patient's complaints regarding vertigo and imbalance disappeared, but the severe sensorineural hearing loss persisted...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29763967/machine-learning-algorithms-for-outcome-prediction-in-chemo-radiotherapy-an-empirical-comparison-of-classifiers
#12
Timo M Deist, Frank J W M Dankers, Gilmer Valdes, Robin Wijsman, I-Chow Hsu, Cary Oberije, Tim Lustberg, Johan van Soest, Frank Hoebers, Arthur Jochems, Issam El Naqa, Leonard Wee, Olivier Morin, David R Raleigh, Wouter Bots, Johannes H Kaanders, José Belderbos, Margriet Kwint, Timothy Solberg, René Monshouwer, Johan Bussink, Andre Dekker, Philippe Lambin
PURPOSE: Machine learning classification algorithms (classifiers) for prediction of treatment response are becoming more popular in radiotherapy literature. General machine learning literature provides evidence in favor of some classifier families (random forest, support vector machine, gradient boosting) in terms of classification performance. The purpose of this study is to compare such classifiers specifically for (chemo)radiotherapy datasets and to estimate their average discriminative performance for radiation treatment outcome prediction...
May 15, 2018: Medical Physics
https://www.readbyqxmd.com/read/29747136/psychological-interventions-for-caregivers-of-people-with-bipolar-disorder-a-systematic-review-and-meta-analysis
#13
REVIEW
Ella Baruch, Nancy Pistrang, Chris Barker
AIMS: Clinical guidelines recommend that psychological interventions be offered to caregivers of people with bipolar disorder. However, there is little clarity about the efficacy of such interventions. This review examined the efficacy of psychological interventions in improving caregiver-focused outcomes, including burden, psychological symptoms and knowledge. METHOD: A systematic search for controlled trials was conducted using a combination of electronic database searches (PsycINFO, MEDLINE, and CENTRAL), and hand searches...
August 15, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29731919/elevated-growth-differentiating-factor-15-expression-predicts-long-term-benefit-of-docetaxel-cisplatin-and-5-fluorouracil-induction-chemotherapy-in-patients-with-oral-cancer
#14
Xiao Tang, Yong-Jie Hu, Wu-Tong Ju, Yong Fu, Wen-Wen Sun, Ying Liu, Yi-Ran Tan, Li-Zhen Wang, Jiang Li, Yao-Yao Tu, Chen-Ping Zhang, Zhi-Yuan Zhang, Lai-Ping Zhong
Our previous phase 3 trial (NCT01542931) failed to demonstrate improved survival when docetaxel, cisplatin and 5-fluorouracil (TPF) induction chemotherapy was introduced prior to surgery and postoperative radiotherapy in patients with locally advanced oral squamous cell carcinoma (OSCC). The aim of the present study was to investigate the long-term predictive value of GDF15 expression for potential personalized treatment strategies in OSCC. A total of 256 patients with stage III/IVA OSCC from our phase 3 trial were enrolled in the present study...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29709727/clinical-outcomes-of-a-vitrified-donor-oocyte-programme-a-single-uk-centre-experience
#15
S Seshadri, W Saab, H Exeter, E Drew, A Petrie, M Davies, P Serhal
OBJECTIVE: To assess the survival rate of vitrified oocytes used in an egg recipient programme and compare the clinical outcomes of pregnancy and live-birth rates per warmed oocyte with fresh autologous oocytes. The differences in the obstetrical outcomes between the two groups were also studied. DESIGN: A prospective case control study from a single in-vitro fertilisaton (IVF) Centre in UK SETTING: Centre of Reproductive and Genetic Health (CRGH), London POPULATION: Vitrified oocytes from egg donors and autologous fresh oocytes from patients attending for an IVF cycle METHODS: The study group consisted of 1490 vitrified oocytes, which were obtained from 145 egg donors who underwent a stimulation cycle at CRGH Centre...
April 22, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29707818/a-sensitivity-analysis-for-missing-outcomes-due-to-truncation-by-death-under-the-matched-pairs-design
#16
Kosuke Imai, Zhichao Jiang
The matched-pairs design enables researchers to efficiently infer causal effects from randomized experiments. In this paper, we exploit the key feature of the matched-pairs design and develop a sensitivity analysis for missing outcomes due to truncation by death, in which the outcomes of interest (e.g., quality of life measures) are not even well defined for some units (e.g., deceased patients). Our key idea is that if 2 nearly identical observations are paired prior to the randomization of the treatment, the missingness of one unit's outcome is informative about the potential missingness of the other unit's outcome under an alternative treatment condition...
April 29, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29669529/improving-quality-of-life-through-the-routine-use-of-the-patient-concerns-inventory-for-head-and-neck-cancer-patients-a-cluster-preference-randomized-controlled-trial
#17
Simon N Rogers, Derek Lowe, Cher Lowies, Seow Tien Yeo, Christine Allmark, Dominic Mcavery, Gerald M Humphris, Robert Flavel, Cherith Semple, Steven J Thomas, Anastasios Kanatas
BACKGROUND: The consequences of treatment for Head and Neck cancer (HNC) patients has profound detrimental impacts such as impaired QOL, emotional distress, delayed recovery and frequent use of healthcare. The aim of this trial is to determine if the routine use of the Patients Concerns Inventory (PCI) package in review clinics during the first year following treatment can improve overall quality of life, reduce the social-emotional impact of cancer and reduce levels of distress. Furthermore, we aim to describe the economic costs and benefits of using the PCI...
April 18, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29657903/obstructive-sleep-apnea-as-a-risk-factor-for-atrial-fibrillation-a-meta-analysis
#18
Irini Youssef, Haroon Kamran, Mena Yacoub, Nirav Patel, Clive Goulbourne, Shweta Kumar, Jesse Kane, Haley Hoffner, Moro Salifu, Samy I McFarlane
Objectives: To conducted a meta-analysis assessing the relationship between Obstructive Sleep Apnea (OSA) and the risk of Atrial Fibrillation (AF). Methods: We searched PUBMED, Medline, and Cochrane Library using the keywords "atrial fibrillation", "obstructive sleep apnea" and "sleep disordered breathing (SDB)". All subjects included had established diagnosis of OSA/SDB. We then compared the occurrence of AF versus no AF. Analysis done with Comprehensive Meta-Analysis package V3 (Biostat, USA)...
2018: Journal of Sleep Disorders & Therapy
https://www.readbyqxmd.com/read/29657199/impact-of-body-mass-index-on-progression-of-primary-immunoglobulin-a-nephropathy
#19
Shankar Prasad Nagaraju, Dharshan Rangaswamy, Aswani Srinivas Mareddy, Srikanth Prasad, Sindhu Kaza, Srinivas Shenoy, Karan Saraf, Ravindra Prabhu Attur, Rajeevalochana Parthasarathy, Srinivas Kosuru, Uday Venkat Mateti, Vasudeva Guddattu, Sindhura Lakshmi Koulmane Laxminarayana
The role of obesity in the progression of primary glomerular diseases is controversial. A few studies report overweight/obesity as a risk factor for disease progression in immunoglobulin A nephropathy (IgAN), and the real impact of it still remains unclear. The aim of this study was to elucidate the effect of body mass index (BMI) on disease progression and proteinuria in patients with IgAN in Indian population. A cohort of biopsy-proven primary IgAN patients diagnosed between March 2010 and February 2015 who had a follow-up for a minimum of 12 months were included in the study...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29614982/how-to-customize-a-bona-fide-psychotherapy-for-generalized-anxiety-disorder-a-two-arms-patient-blinded-abab-crossed-therapist-randomized-clinical-implementation-trial-design-implement-2-0
#20
Christoph Flückiger, Christine Wolfer, Judith Held, Peter Hilpert, Julian Rubel, Mathias Allemand, Richard E Zinbarg, Andreea Vîslă
BACKGROUND: Bona fide psychotherapy approaches are effective treatments for generalized anxiety disorder (GAD) compared to no-treatment conditions. Treatment manuals and protocols allow a relatively high degree of freedom for the way therapists implement these overall treatment packages and there is a systematic lack of knowledge on how therapists should customize these treatments. The present study experimentally examines two implementation strategies of customizing a bona fide psychotherapy approach based on a 16 session time-limited cognitive-behavioral therapy (CBT) protocol and their relation to the post-session and ultimate treatment outcomes...
April 3, 2018: BMC Psychiatry
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