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https://www.readbyqxmd.com/read/28077345/tips-and-traps-lessons-from-codesigning-a-clinician-e-monitoring-tool-for-computerized-cognitive-behavioral-therapy
#1
Frederick Sundram, Susan J Hawken, Karolina Stasiak, Mathijs Fg Lucassen, Theresa Fleming, Matthew Shepherd, Andrea Greenwood, Raechel Osborne, Sally N Merry
BACKGROUND: Computerized cognitive behavioral therapy (cCBT) is an acceptable and promising treatment modality for adolescents with mild-to-moderate depression. Many cCBT programs are standalone packages with no way for clinicians to monitor progress or outcomes. We sought to develop an electronic monitoring (e-monitoring) tool in consultation with clinicians and adolescents to allow clinicians to monitor mood, risk, and treatment adherence of adolescents completing a cCBT program called SPARX (Smart, Positive, Active, Realistic, X-factor thoughts)...
January 11, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28070261/the-effect-of-utilizing-organizational-culture-improvement-model-of-patient-education-on-coronary-artery-bypass-graft-patients-anxiety-and-satisfaction-theory-testing
#2
Mansoureh Ashghali Farahani, Fatemeh Ghaffari, Faezeh Norouzinezhad, Roohangiz Jamshidi Orak
INTRODUCTION: Due to the increasing prevalence of arteriosclerosis and the mortality caused by this disease, Coronary Artery Bypass Graft (CABG) has become one of the most common surgical procedures. Utilization of patient education is approved as an effective solution for increasing patient survival and outcomes of treatment. However, failure to consider different aspects of patient education has turned this goal into an unattainable one. The objective of this research was to determine the effect of utilizing the organizational culture improvement model of patient education on CABG patients' anxiety and satisfaction...
November 2016: Electronic Physician
https://www.readbyqxmd.com/read/28067944/intensive-case-management-for-severe-mental-illness
#3
REVIEW
Marina Dieterich, Claire B Irving, Hanna Bergman, Mariam A Khokhar, Bert Park, Max Marshall
BACKGROUND: Intensive Case Management (ICM) is a community-based package of care aiming to provide long-term care for severely mentally ill people who do not require immediate admission. Intensive Case Management evolved from two original community models of care, Assertive Community Treatment (ACT) and Case Management (CM), where ICM emphasises the importance of small caseload (fewer than 20) and high-intensity input. OBJECTIVES: To assess the effects of ICM as a means of caring for severely mentally ill people in the community in comparison with non-ICM (caseload greater than 20) and with standard community care...
January 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28047670/su-f-p-20-predicting-waiting-times-in-radiation-oncology-using-machine-learning
#4
A Joseph, D Herrera, T Hijal, L Hendren, A Leung, J Wainberg, M Sawaf, M Gorshkov, R Maglieri, M Keshavarz, J Kildea
PURPOSE: Waiting times remain one of the most vexing patient satisfaction challenges facing healthcare. Waiting time uncertainty can cause patients, who are already sick or in pain, to worry about when they will receive the care they need. These waiting periods are often difficult for staff to predict and only rough estimates are typically provided based on personal experience. This level of uncertainty leaves most patients unable to plan their calendar, making the waiting experience uncomfortable, even painful...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047578/su-f-r-36-validating-quantitative-radiomic-texture-features-for-oncologic-pet-a-digital-phantom-study
#5
F Yang, Y Yang, L Young
PURPOSE: Radiomic texture features derived from the oncologic PET have recently been brought under intense investigation within the context of patient stratification and treatment outcome prediction in a variety of cancer types; however, their validity has not yet been examined. This work is aimed to validate radiomic PET texture metrics through the use of realistic simulations in the ground truth setting. METHODS: Simulation of FDG-PET was conducted by applying the Zubal phantom as an attenuation map to the SimSET software package that employs Monte Carlo techniques to model the physical process of emission imaging...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047270/su-f-t-231-improving-the-efficiency-of-a-radiotherapy-peer-review-system-for-quality-assurance
#6
S Hsu, A Basavatia, M Garg, S Kalnicki, W Tome
PURPOSE: To improve the efficiency of a radiotherapy peer-review system using a commercially available software application for plan quality evaluation and documentation. METHODS: A commercial application, FullAccess (Radialogica LLC, Version 1.4.4), was implemented in a Citrix platform for peer-review process and patient documentation. This application can display images, isodose lines, and dose-volume histograms and create plan reports for peer-review process...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047061/su-f-r-07-radiomics-of-ct-features-and-associations-and-correlation-with-outcomes-following-lung-sbrt
#7
E Schreibmann, A Iwinski Sutter, D Whitaker, J Switchenko, E Elder, K Higgins, P Patel
OBJECTIVE: To investigate the prognostic significance of image gradients and in predicting clinical outcomes in a patients with non-small cell lung cancer treated with stereotactic body radiotherapy (SBRT) on 71 patients with 83 treated lesions. METHODS: The records of patients treated with lung SBRT were retrospectively reviewed. When applicable, SBRT target volumes were modified to exclude any overlap with pleura, chestwall, or mediastinum. The ITK software package was utilized to generate quantitative measures of image intensity, inhomogeneity, shape morphology and first and second-order CT textures...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044376/psychosocial-interventions-in-opiate-substitution-treatment-services-does-the-evidence-provide-a-case-for-optimism-or-nihilism
#8
Ed Day, Luke Mitcheson
BACKGROUND AND AIMS: Clinical guidelines from around the world recommend the delivery of psychosocial interventions as part of routine care in opiate substitution treatment (OST) programmes. However, although individual studies demonstrate benefit for structured psychosocial interventions, meta-analytical reviews find no benefit for manual-based treatments beyond 'routine counselling'. ANALYSIS: We consider the question of whether OST medication alone is sufficient to produce the required outcomes, or whether greater efforts should be made to provide high-quality psychosocial treatment alongside medication...
January 2, 2017: Addiction
https://www.readbyqxmd.com/read/28004618/organisation-of-services-for-managing-adhd
#9
D R Coghill
There is considerable variation in practice, both between and with different countries in the management of attention deficit hyperactivity disorder (ADHD). Whilst there is no one optimal model of service organisation there are general principles of care that can be introduced to reduce this variability. There are frequent debates and discussions about which professional group is best placed to manage ADHD at different points in the life cycle. Who delivers care is however less important than ensuring that training schemes provide adequate exposure, training and experience to both the core and non-core skills required to provide a comprehensive package of care...
December 22, 2016: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/27982543/in-vivo-bioluminescence-imaging-using-orthotopic-xenografts-towards-patient-s-derived-xenograft-medulloblastoma-models
#10
Fatemeh Asadzadeh, Veronica Ferrucci, Pasqualino DE Antonellis, Massimo Zollo
BACKGROUND: Medulloblastoma is a cerebellar neoplasia of the central nervous system. Four molecular subgrups have been identified (MBWNT, MBSHH, MBgroup3 and MBgroup4) with distinct genetics and clinical outcome. Among these, MBgroup3-4 are highly metastatic with the worst prognosis. The current standard therapy includes surgery, radiation and chemotherapy. Thus, specific treatments adapted to cure those different molecular subgroups are needed. The use of orthotopic xenograft models, together with the non-invasive in vivo biolumiscence imaging (BLI) technology, is emerging during preclinical studies to test novel therapeutics for medulloblastoma treatment...
March 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27966231/assessing-a-surrogate-predictive-value-a-causal-inference-approach
#11
Ariel Alonso, Wim Van der Elst, Paul Meyvisch
Several methods have been developed for the evaluation of surrogate endpoints within the causal-inference and meta-analytic paradigms. In both paradigms, much effort has been made to assess the capacity of the surrogate to predict the causal treatment effect on the true endpoint. In the present work, the so-called surrogate predictive function (SPF) is introduced for that purpose, using potential outcomes. The relationship between the SPF and the individual causal association, a new metric of surrogacy recently proposed in the literature, is studied in detail...
December 13, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27965858/development-and-feasibility-of-a-swallowing-intervention-package-sip-for-patients-receiving-radiotherapy-treatment-for-head-and-neck-cancer-the-sip-study-protocol
#12
Mary Wells, Emma King, Kate Toft, Fiona MacAulay, Joanne Patterson, Nadine Dougall, Nick Hulbert-Williams, Sally Boa, Eleanor Slaven, Julie Cowie, John McGarva, Patricia Gail Niblock, Julie Philp, Justin Roe
BACKGROUND: Head and neck cancer (HNC) is the sixth most common cancer worldwide, and the functional, psychological and social consequences of HNC cancer and its treatment can be severe and chronic. Dysphagia (swallowing problems) affects up to two thirds of patients undergoing combined chemoradiotherapy. Recent reviews suggest that prophylactic swallowing exercises may improve a range of short- and long-term outcomes; however, the importance of psychological and behavioural factors on adherence to swallowing exercises has not been adequately studied...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27965485/effect-of-intracanal-cryotherapy-and-negative-irrigation-technique-on-postendodontic-pain
#13
Talal Al-Nahlawi, Talaat Abo Hatab, Mahmoud Abd Alrazak, Ahmad Al-Abdullah
AIM: To evaluate the effect of intracanal cryotherapy with negative pressure irrigation (EndoVac) on postendodontic pain after vital single-visit root canal treatment (RCT). MATERIALS AND METHODS: A total of 75 single-rooted teeth with single root canal were treated endodontically. After root canal preparation with Protaper Universal rotary system and irrigation, teeth were divided randomly into three groups (n = 25) according to additional irrigation protocol as follows: Group I: No additional irrigation was applied (control); group II: A 20 mL of room temperature saline was irrigated during 5 minutes using EndoVac, and group III: A 20 mL of 2 to 4°C cold saline was irrigated during 5 minutes using EndoVac...
December 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27955972/the-importance-of-the-mesofascial-interface-in-complete-mesocolic-excision
#14
REVIEW
Luca Maria Siani, Gianluca Garulli
Complete mesocolic excision (CME) with Central Vascular Ligation (CVL) is progressively gaining acceptance as the most updated surgical treatment in the multimodal management of colonic cancer. The concept is based on excision of the affected organ with its related primitive dorsal mesenterium as an intact package to maximize local clearance, and high tie ligation to boost regional control, translating the original concept of Total Mesorectal Excision proposed by Heald for rectal cancer. Aim of this review is to analyze the modern concept of the mesenteric organ, with particular regard to the interfaces between its single components and the importance of the meso-fascial interface as the correct plane of separation...
December 9, 2016: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/27942516/causal-mediation-analysis-in-the-context-of-clinical-research
#15
EDITORIAL
Zhongheng Zhang, Cheng Zheng, Chanmin Kim, Sven Van Poucke, Su Lin, Peng Lan
Clinical researches usually collected numerous intermediate variables besides treatment and outcome. These variables are often incorrectly treated as confounding factors and are thus controlled using a variety of multivariable regression models depending on the types of outcome variable. However, these methods fail to disentangle underlying mediating processes. Causal mediation analysis (CMA) is a method to dissect total effect of a treatment into direct and indirect effect. The indirect effect is transmitted via mediator to the outcome...
November 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27936886/quantitative-radiomics-studies-for-tissue-characterization-a-review-of-technology-and-methodological-procedures
#16
Ruben T H M Larue, Gilles Defraene, Dirk De Ruysscher, Philippe Lambin, Wouter van Elmpt
Quantitative analysis of tumour characteristics based on medical imaging is an emerging field of research. In recent years quantitative imaging features derived from CT, PET and MR scans were shown to be of added value in the prediction of outcome parameters in oncology, in what is called the radiomics field. However, results might be difficult to compare due to a lack of standardized methodologies to conduct quantitative image analyses. In this review we aim to present an overview of the current challenges, technical routines and protocols that are involved in quantitative imaging studies...
December 12, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27935798/health-gains-and-financial-protection-provided-by-the-ethiopian-mental-health-strategy-an-extended-cost-effectiveness-analysis
#17
Kjell Arne Johansson, Kirsten Bjerkreim Strand, Abebaw Fekadu, Dan Chisholm
BACKGROUND: Mental and neurological (MN) health care has long been neglected in low-income settings. This paper estimates health and non-health impacts of fully publicly financed care for selected key interventions in the National Mental Health Strategy in Ethiopia for depression, bipolar disorder, schizophrenia and epilepsy. METHODS: A methodology of extended cost-effectiveness analysis (ECEA) is applied to MN health care in Ethiopia. The impact of providing a package of selected MN interventions free of charge in Ethiopia is estimated for: epilepsy (75% coverage, phenobarbital), depression (30% coverage, fluoxetine, cognitive therapy and proactive case management), bipolar affective disorder (50% coverage, valproate and psychosocial therapy) and schizophrenia (75% coverage, haloperidol plus psychosocial treatment)...
October 9, 2016: Health Policy and Planning
https://www.readbyqxmd.com/read/27917593/%C3%AE-markov-model-for-longitudinal-studies-with-incomplete-dichotomous-outcomes
#18
Orestis Efthimiou, Nicky Welton, Myrto Samara, Stefan Leucht, Georgia Salanti
Missing outcome data constitute a serious threat to the validity and precision of inferences from randomized controlled trials. In this paper, we propose the use of a multistate Markov model for the analysis of incomplete individual patient data for a dichotomous outcome reported over a period of time. The model accounts for patients dropping out of the study and also for patients relapsing. The time of each observation is accounted for, and the model allows the estimation of time-dependent relative treatment effects...
December 5, 2016: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/27914323/quantitative-farm-to-fork-human-norovirus-exposure-assessment-of-individually-quick-frozen-raspberries-and-raspberry-puree
#19
L Jacxsens, A Stals, A De Keuckelaere, B Deliens, A Rajkovic, M Uyttendaele
A quantitative human norovirus (NoV) exposure model describing transmission of NoV during pre-harvest, harvest and further processing of soft red fruits exemplified by raspberries is presented. The outcomes of the model demonstrate the presence of NoV in raspberry puree or individual quick frozen (IQF) raspberry fruits and were generated by Monte Carlo simulations by combining GoldSim® and @Risk® software. Input data were collected from scientific literature, observational studies and assumptions. NoV contamination of soft red fruits is assumed to take place at farms by application of contaminated water for pesticides dilution or by berries' pickers shedding NoV...
February 2, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27904561/analysis-of-outcomes-and-prognostic-factors-of-acute-lymphoblastic-leukemia-patients-treated-by-mcp841-protocol-a-regional-cancer-center-experience
#20
Akhil Kapoor, Ashok Kalwar, Narender Kumar, Mukesh Kumar Singhal, Surender Beniwal, Harvindra Singh Kumar
BACKGROUND: A dramatic improvement in the survival of acute lymphoblastic leukemia (ALL) patients in the last three decades has been observed. MCP 841 protocol is an old but effective tool with tolerable toxicities. The objective of this study was to estimate the relapse-free survival of ALL patients treated uniformly with MCP 841 protocol on the basis of various prognostic factors. MATERIALS AND METHODS: The study design was retrospective and it was conducted in a regional cancer center of Northwest India...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
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