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https://www.readbyqxmd.com/read/29431912/polymorphism-in-dural-arteriovenous-fistula-matrix-metalloproteinase-2-1306-c-t-as-a-potential-risk-factor-for-sinus-thrombosis
#1
Yuang-Seng Tsuei, Ying-Erh Chou, Wen-Hsien Chen, Chao-Bao Luo, Shun-Fa Yang
BACKGROUND: Dural arteriovenous fistula (DAVF) is a rare but important cerebrovascular disorder in adults. Little is known about the molecular genetic pathogenesis underlying the development of DAVF. OBJECTIVES: The present study was conducted to investigate the associations of gene polymorphisms and DAVF. MATERIALS AND METHODS: Using real-time polymerase chain reaction (PCR) genotyping, 7 single-nucleotide polymorphisms (SNPs) of angiogenesis-related genes were analyzed in 72 DAVF patients...
February 12, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29429002/interleukin-6-mediated-endothelial-barrier-disturbances-can-be-attenuated-by-blockade-of-the-il6-receptor-expressed-in-brain-microvascular-endothelial-cells
#2
Kinga G Blecharz-Lang, Josephin Wagner, Alexa Fries, Melina Nieminen-Kelhä, Jörg Rösner, Ulf C Schneider, Peter Vajkoczy
Compromised blood-brain barrier (BBB) by dysregulation of cellular junctions is a hallmark of many cerebrovascular disorders due to the pro-inflammatory cytokines action. Interleukin 6 (IL6) is implicated in inflammatory processes and in secondary brain injury after subarachnoid hemorrhage (SAH) but its role in the maintenance of cerebral endothelium still requires a precise elucidation. Although IL6 has been shown to exert pro-inflammatory action on brain microvascular endothelial cells (ECs), the expression of one of the IL6 receptors, the IL6R is controversially discussed...
February 10, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29424037/severity-of-osas-cpap-and-cardiovascular-events-a-follow-up-study
#3
Francesco Baratta, Daniele Pastori, Mario Fabiani, Valerio Fabiani, Fabrizio Ceci, Rossella Lillo, Valeria Lolli, Marco Brunori, Gaetano Pannitteri, Elena Cravotto, Corrado De Vito, Francesco Angelico, Maria Del Ben
BACKGROUND: Previous studies suggested obstructive sleep apnea syndrome (OSAS) as a major risk factor for incident cardiovascular events. However, the relationship between OSAS severity, the use of continuous positive airway pressure (CPAP) treatment and the development of cardiovascular disease is still matter of debate. STUDY OBJECTIVES: The aim was to test the association between OSAS and cardiovascular events in patients with concomitant cardio-metabolic diseases and the potential impact of CPAP therapy on cardiovascular outcomes...
February 9, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29419677/risk-of-major-comorbidities-among-workers-with-hemophilia-a-14-year-population-based-study
#4
Wei-Min Chu, Hsin-En Ho, Jiaan-Der Wang, Wei-Cheng Chan, Yi-Sheng Liou, Wen-Chao Ho, Sung-Yuan Hu, Yu-Tse Tsan
Multiple comorbidities, especially musculoskeletal dysfunction and cerebrovascular disease, remain barriers to normal social participation among persons with hemophilia (PWH). However, the relative health effects of such comorbidities on workers with hemophilia have seldom been explored. In this study, we investigated the incidence of comorbidities and their risk factors among workers with hemophilia.The study compared the incidence and risk factors of the major comorbidities of 411 workers with hemophilia enrolled in Taiwan's National Health Insurance Research Database between 1997 and 2010 with an age- and sex-matched general population...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29416039/bfgf-plays-a-neuroprotective-role-by-suppressing-excessive-autophagy-and-apoptosis-after-transient-global-cerebral-ischemia-in-rats
#5
Dawei Sun, Wenying Wang, Xintao Wang, Yan Wang, Xiaotao Xu, Feng Ping, Yu Du, Wei Jiang, Derong Cui
Transient global cerebral ischemia (tGCI) is a cerebrovascular disorder that can cause apoptotic neuronal damage and functional deficits. Basic fibroblast growth factor (bFGF) was reported to be highly expressed in the central nervous system (CNS) and to exert neuroprotective effects against different CNS diseases. However, the effects of bFGF on tGCI have not been studied intensively. This study was conducted to investigate the effect of bFGF and its underlying mechanism in an animal model of tGCI. After intracerebroventricular (i...
February 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29410070/the-neuroimaging-basis-of-apathy-empirical-findings-and-conceptual-challenges
#6
Sergio E Starkstein, Simone Brockman
Apathy, usually defined as loss of motivation, is common in both neurodegenerative conditions such as Alzheimer's disease, and acute neurological disorders such as stroke. Neuroradiological studies on the imaging correlates of apathy have used a variety of methods such as structural and functional magnetic resonance imaging, diffusion tensor imaging, and single photon and positron emission tomography to assess brain metabolic activity and specific synaptic receptors. Dysfunction of the anterior cingulate cortex (ACC) is the strongest anatomical correlate of apathy in Alzheimer's disease, whereas lesions of the basal ganglia are the most common correlates of apathy in cerebrovascular disorders...
February 2, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29408903/vitamin-d-deficiency-causes-inward-hypertrophic-remodeling-and-alters-vascular-reactivity-of-rat-cerebral-arterioles
#7
Éva Pál, Leila Hadjadj, Zoltán Fontányi, Anna Monori-Kiss, Zsuzsanna Mezei, Norbert Lippai, Attila Magyar, Andrea Heinzlmann, Gellért Karvaly, Emil Monos, György Nádasy, Zoltán Benyó, Szabolcs Várbíró
BACKGROUND AND PURPOSE: Vitamin D deficiency (VDD) is a global health problem, which can lead to several pathophysiological consequences including cardiovascular diseases. Its impact on the cerebrovascular system is not well understood. The goal of the present work was to examine the effects of VDD on the morphological, biomechanical and functional properties of cerebral arterioles. METHODS: Four-week-old male Wistar rats (n = 11 per group) were either fed with vitamin D deficient diet or received conventional rat chow with per os vitamin D supplementation...
2018: PloS One
https://www.readbyqxmd.com/read/29408019/impact-of-atrial-fibrillation-on-cognitive-function-psychological-distress-quality-of-life-and-impulsiveness
#8
Rokas Serpytis, Aurelija Navickaite, Emilija Serpytiene, Jurate Barysiene, Germanas Marinskis, Dalius Jatuzis, Zaneta Petrulioniene, Aleksandras Laucevicius, Pranas Serpytis
OBJECTIVE: Atrial fibrillation is the most common cardiac arrhythmia and a known risk factor for cerebrovascular stroke. Atrial fibrillation and long standing hypertension may produce ischemic lesions leading to progressive cognitive impairment. The impact of atrial fibrillation alone on cognitive impairment has not been evaluated. Our objective was to compare cognitive function, quality of life, psychological distress and impulsiveness in people with atrial fibrillation and a matched control group...
January 30, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29406924/white-matter-hyperintensities-on-mri-in-dementia-with-lewy-bodies-parkinson-s-disease-with-dementia-and-alzheimer-s-disease
#9
Hideto Joki, Yuichi Higashiyama, Yoshiharu Nakae, Chiharu Kugimoto, Hiroshi Doi, Katsuo Kimura, Hitaru Kishida, Naohisa Ueda, Tatsu Nakano, Tatsuya Takahashi, Shigeru Koyano, Hideyuki Takeuchi, Fumiaki Tanaka
BACKGROUND: In dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD), it is still debated whether white matter hyperintensities (WMH) on MRI reflect atherosclerotic cerebrovascular changes or Alzheimer's disease (AD)-related pathology such as cerebral amyloid angiopathy. To examine AD-related pathology in DLB and PDD, we compared the severity of WMH and medial temporal lobe atrophy among patients with DLB, PDD, non-demented PD (PDND), and AD. METHODS: We retrospectively studied sex- and age-matched outpatients with AD, DLB, PDD, and PDND, as well as subjects without central nervous system disorders as normal controls (n=50 each)...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29396300/traumatic-brain-injury-and-alzheimer-s-disease-the-cerebrovascular-link
#10
REVIEW
Jaime Ramos-Cejudo, Thomas Wisniewski, Charles Marmar, Henrik Zetterberg, Kaj Blennow, Mony J de Leon, Silvia Fossati
Traumatic brain injury (TBI) and Alzheimer's disease (AD) are devastating neurological disorders, whose complex relationship is not completely understood. Cerebrovascular pathology, a key element in both conditions, could represent a mechanistic link between Aβ/tau deposition after TBI and the development of post concussive syndrome, dementia and chronic traumatic encephalopathy (CTE). In addition to debilitating acute effects, TBI-induced neurovascular injuries accelerate amyloid β (Aβ) production and perivascular accumulation, arterial stiffness, tau hyperphosphorylation and tau/Aβ-induced blood brain barrier damage, giving rise to a deleterious feed-forward loop...
January 30, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29396057/cerebrovascular-disorders-and-fahr-s-disease-report-of-two-cases-and-literature-review
#11
Francesco Giovanni Sgulò, Giuseppe di Nuzzo, Matteo de Notaris, Vincenzo Seneca, Giuseppe Catapano
Fahr's disease is a rare idiopathic nosological entity, characterized by calcification of the basal ganglia and dentate nuclei of the cerebellum. Sometimes it may be associated to other diseases like cerebrovascular disorders. However, this link remains unclear and it needs to be further validated. We report two cases of patients with cerebrovascular disorders and Fahr's disease. In the first case, a 69-years-old woman with right internal capsule-basal ganglia haemorrhage. In the second case, a 72-years-old woman with ischemic stroke and pericallosal artery aneurysm...
January 22, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29392085/causes-of-death-in-chinese-patients-with-multiple-system-atrophy
#12
LingYu Zhang, Bei Cao, Yutong Zou, Qian-Qian Wei, RuWei Ou, Wanglin Liu, Bi Zhao, Jing Yang, Ying Wu, HuiFang Shang
The objective of this study was to explore the causes of death in Chinese patients with multiple system atrophy (MSA) as well as differences in the cause of death according to sex, subtype, disease onset, and whether the disease was accompanied by nocturnal stridor. A total of 131 MSA patients were enrolled and followed up once every year until their deaths. Clinical information was collected by neurologists, and the cause of death of the MSA patients was obtained from the patients' relatives or caregivers...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29391373/do-police-officers-and-firefighters-have-a-higher-risk-of-disease-than-other-public-officers-a-13-year-nationwide-cohort-study-in-south-korea
#13
Minkyung Han, Sohee Park, Jong Heon Park, Seung-Sik Hwang, Inah Kim
OBJECTIVES: The work of public officers involves repeated and long-term exposure to heavy workloads, high job strain and workplace violence, all of which negatively impact physical and mental health. This study aimed to evaluate and compare the incidences of diseases among different categories of public officers in Korea, in order to further understand the health risks associated with these occupations. DESIGN: A cohort study using the National Health Insurance data...
January 31, 2018: BMJ Open
https://www.readbyqxmd.com/read/29389776/uric-acid-and-cognitive-decline-a-double-edge-sword
#14
Augustin Latourte, Thomas Bardin, Pascal Richette
PURPOSE OF REVIEW: This narrative review aims to highlight recent findings on the relation between uric acid level and cognitive decline or dementia. RECENT FINDINGS: The antioxidant properties of uric acid, which have supported the hypothesis that uric acid may be neuroprotective, have been questioned by preclinical data. Studies investigating the relation between serum uric acid (SUA) level and Alzheimer disease are mostly cross-sectional, and results are often inconclusive...
March 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29380517/therapeutic-efficacy-of-low-dose-25%C3%A2-mg-mirabegron-therapy-for-patients-with-mild-to-moderate-overactive-bladder-symptoms-due-to-central-nervous-system-diseases
#15
Sheng-Fu Chen, Hann-Chorng Kuo
OBJECTIVE: The incidence of overactive bladder (OAB) increases with age, especially in patients with central nervous system (CNS) disorders such as cerebrovascular accident (CVA) and Parkinson's disease (PD). Mirabegron is a novel medication for the treatment of OAB. The present study investigated the therapeutic effect of mirabegron on OAB patients with CNS diseases. METHODS: Patients with CVA, PD, dementia, and OAB symptoms were consecutively enrolled in the study group, and mirabegron 25 mg q...
January 30, 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29380261/intracranial-arterial-calcifications-as-a-prognostic-factor-for-subsequent-major-adverse-cardiovascular-events-mace
#16
Frederik F Strobl, Beatrice Kuhlin, Robert Stahl, Bastian O Sabel, Andreas D Helck, Andreas Schindler, Matthias Witt, Fabian Bamberg, Maximilian F Reiser, Tobias Saam
BACKGROUND: Intracranial arterial calcifications (ICAC) are often detected on unenhanced CT of patients with an age > 60. However, association with the subsequent occurrence of major adverse cardiovascular events (MACE) has not yet been evaluated. PURPOSE: This study aimed at evaluating the association of ICAC with subsequent MACE and overall mortality. METHODS: In this retrospective, IRB approved study, we included 175 consecutive patients (89 males, mean age 78...
January 30, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29373803/knockdown-of-nrf2-inhibits-angiogenesis-by-down-regulating-vegf-expression-through-pi3k-akt-signaling-pathway-in-cerebral-microvascular-endothelial-cells-under-hypoxic-conditions
#17
Yujing Huang, Ying Mao, Huiying Li, Guangxun Shen, Guangxian Nan
Ischemic stroke is a major cerebrovascular disease resulting from a transient or permanent local reduction of cerebral blood flow. Angiogenesis plays an important role in cerebral microvascular repair after ischemic stroke. This study aimed at investigating the effect of NF-E2-related factor 2 (Nrf2) on the angiogenesis of mouse cerebral microvascular endothelial bEnd.3 cells in a hypoxic environment. We found that Nrf2 expression was temporarily increased in hypoxia-induced bEnd.3 cells. Knockdown of Nrf2 inhibited the proliferation, migration as well as tube formation in hypoxia-induced bEnd...
January 26, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29373707/cardiovascular-and-cerebrovascular-comorbidities-of-juvenile-dermatomyositis-in-us-children-an-analysis-of-the-national-inpatient-sample
#18
Jonathan I Silverberg, Lauren Kwa, Michael C Kwa, Anne E Laumann, Kaveh Ardalan
Objective: JDM is associated with multiple potential risk factors for cardiovascular disease, including reduced heart rate variability, systolic/diastolic cardiac dysfunction, abnormal brachial artery reactivity and metabolic syndrome. However, little is known about cardiovascular risk in JDM. We sought to examine the association between JDM and cardiovascular risk factors and disease in US children. Methods: Data from the 2002-12 National Inpatient Sample was analysed, including ∼20% of all US hospitalizations (n = 14 535 620 paediatric hospitalizations)...
January 24, 2018: Rheumatology
https://www.readbyqxmd.com/read/29372939/can-statins-diminish-depression
#19
Devina Singh, Steven Lippmann
Depression is a common malady associated with numerous chronic medical conditions such as coronary artery disease, hypertension, and diabetes. Statins provide protection against coronary and cerebrovascular diseases by decreasing cholesterol synthesis in the liver. Statin medications also reduce inflammation. Since the pathophysiology of depression involves inflammation, statins could have a role in the treatment of mood disorders and might become a pharmacotherapy option for patients experiencing depression...
January 25, 2018: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29364453/moyamoya-syndrome-associated-with-neurofibromatosis-type-1-in-a-pediatric-patient
#20
Natália Battisti Serafini, Cássio Battisti Serafini, Alanna Santoro Vinhas, Marcio Barbosa Godinho
Neurofibromatosis type 1 is a multisystem genetic disease of autosomal dominant transmission that reveals important cutaneous manifestations such as café-au-lait spots, multiple neurofibromas, and ephelides in skin fold areas, as well as hamartomatous lesions in the eyes, bones, glands, and central nervous system. Moyamoya disease is a rare progressive vaso-occlusive disorder that occurs with important ischemic cerebrovascular events. Despite the rarity of this association in childhood, children diagnosed with neurofibromatosis type 1 and focal neurologic symptoms should be investigated for moyamoya syndrome...
November 2017: Anais Brasileiros de Dermatologia
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