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cerebrovascular disorder

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https://www.readbyqxmd.com/read/29678126/associations-of-depression-anxiety-and-ptsd-with-neurological-disability-and-cognitive-impairment-in-survivors-of-moyamoya-disease
#1
Chanchan Liu, Xiyan Yi, Ting Li, Lei Xu, Mei Hu, Suming Zhang, Rifeng Jiang
Depression, anxiety and posttraumatic stress disorder (PTSD) are common complications of cerebrovascular diseases. However, they were seldom explored in Moyamoya Disease (MMD) survivors. In this study, we measured the prevalence of depression, anxiety and PTSD in MMD survivors. We evaluated the association of mental disorders with neurological disability and cognitive impairment, and further find out the independent protective and risk factors of neurological disability and cognitive impairment. In MMD survivors, the prevalence of these three mental disorders is high, 46...
April 20, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29673002/incidence-of-and-risk-factors-for-severe-maternal-complications-associated-with-hypertensive-disorders-after-36-weeks-gestation-in-uncomplicated-twin-pregnancies-a-prospective-cohort-study
#2
Ryo Yamamoto, Keisuke Ishii, Haruka Muto, Shiyo Ota, Haruna Kawaguchi, Shusaku Hayashi, Nobuaki Mitsuda
AIM: To elucidate the incidence of and risk factors for severe hypertensive disorders (HD) and related maternal complications in uncomplicated twin pregnancies that reached 36 weeks' gestation. METHODS: We conducted a prospective cohort study of twin pregnancies delivered after 36 weeks' gestation. Cases of twin-twin transfusion syndrome, twin anemia-polycythemia sequence, malformed fetuses, monoamniotic twins, selective reduction, fetal therapy and HD or fetal death before 35 weeks' gestation were excluded...
April 19, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29672868/fetal-cerebral-circulation-as-target-of-maternal-alcohol-consumption
#3
Anna N Bukiya, Alex M Dopico
Alcohol (ethanol) is one of the most widely used psychoactive substances worldwide. Alcohol consumption during pregnancy may result in a wide range of morphological and neurodevelopmental abnormalities termed fetal alcohol spectrum disorders (FASD), with the most severe cases diagnosed as fetal alcohol syndrome (FAS). FAS and FASD are not readily curable and currently represent the leading preventable causes of birth defect and neurodevelopmental delay in the US. The etiology of FAS/FASD remains poorly understood...
April 19, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29671127/quantitative-analysis-of-the-anti-inflammatory-activity-of-orengedokuto-ii-berberine-is-responsible-for-the-inhibition-of-no-production
#4
Naohiro Oshima, Tomofumi Shimizu, Yuji Narukawa, Noriyasu Hada, Fumiyuki Kiuchi
Orengedokuto is a Kampo formula that has been used for removing "heat" and "poison" to treat inflammation, hypertension, gastrointestinal disorders, and liver and cerebrovascular diseases. We report here our analysis of the anti-inflammatory effect of the component crude drugs of orengedokuto and their constituents using the inhibition of nitric oxide (NO) production in the murine macrophage-like cell line J774.1. An initial comparison of NO production inhibitory activities of the extracts of the component crude drugs and their combinations revealed that the activity could be attributed to Phellodendron Bark and Coptis Rhizome...
April 18, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29671021/protective-effect-of-vinpocetine-against-neurotoxicity-of-manganese-in-adult-male-rats
#5
Rania I Nadeem, Hebatalla I Ahmed, Bahia M El-Sayeh
Manganese (Mn) is required for many essential biological processes as well as in the development and functioning of the brain. Extensive accumulation of Mn in the brain may cause central nervous system dysfunction known as manganism, a motor disorder associated with cognitive and neuropsychiatric deficits similar to parkinsonism. Vinpocetine, a synthetic derivative of the alkaloid vincamine, is used to improve the cognitive function in cerebrovascular diseases. It possesses antioxidant and antiinflammatory properties...
April 18, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29668537/cerebral-sinus-venous-thrombosis-and-prothrombotic-risk-factors-in-children-a-single-center-experience-from-turkey
#6
Alper Ozcan, Mehmet Canpolat, Selim Doganay, Ekrem Unal, Musa Karakukcu, Mehmet A Ozdemir, Turkan Patiroglu
BACKGROUND: Cerebral sinus venous thrombosis (CSVT) is a rare cerebrovascular disease that may be life-threatening, especially in children. OBJECTIVE: The purpose of this study was to assess the clinical presentation, radiologic imaging, underlying conditions, treatment, and outcomes of children with CSVT. PATIENTS AND METHODS: In total, 23 consecutive children aged between 1 month to 18 years with CSVT, who were followed-up in Erciyes University Children's Hospital, were retrospectively enrolled in the study from January 2000 to December 2016...
April 17, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29665789/idiopathic-basal-ganglia-calcification-associated-with-cerebral-micro-infarcts-a-case-report
#7
Takuma Nishimoto, Fumiaki Oka, Hideyuki Ishihara, Mizuya Shinoyama, Michiyasu Suzuki
BACKGROUND: Idiopathic basal ganglia calcification (IBGC) is a rare neurodegenerative disorder characterized by symmetric intracranial calcium deposition. We report a patient with IBGC associated with cerebral infarction due to impairment of cerebrovascular reactivity based on single-photon emission computed tomography (SPECT) with acetazolamide challenge. CASE PRESENTATION: A 66-year-old male presented with right conjugate deviation, right hemiparesis and total aphasia due to a convulsive seizure...
April 17, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29664556/clinical-problems-in-hemodialysis-patients-with-autosomal-dominant-polycystic-kidney-disease
#8
REVIEW
Ismail Kocyigit, Eray Eroglu, Ozkan Gungor
Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenic disease characterized by massive enlargement of fluid-filled cysts in the kidney. Due to its genetic pattern, the disease differs from other CKD. ADPKD is a multi-system, progressive disorder which is frequently complicated with hypertension, cardiovascular events and cerebrovascular disease. Thus, there are many clinical problems specific to ADPKD. In this article, we reviewed these clinical problems and their management in ADPKD with hemodialysis patients...
April 17, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29653415/carotid-arteritis-causing-amaurosis-fugax-and-ischaemic-cerebrovascular-events-in-neurosarcoidosis
#9
D P Kidd, D J McCabe, T Wilhelm, M Galloway
OBJECTIVE: To present and review the vascular consequences of arteritis in neurosarcoidosis. PATIENT AND METHODS: neurosarcoidosis is typically an inflammatory disorder of the meninges surrounding the brain and spinal cord. Although inflammation of small and medium sized vessels is seen pathologically and vasculitis is occasionally described, a large intracerebral arteritis has not previously been reported. A few case reports exist, however, which describe the vascular consequences of large vessel compromise in the disorder...
March 22, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29645069/-childhood-ischemic-cerebrovascular-disease-in-a-paediatric-emergency-service-a-descriptive-study
#10
P Garcia-Sanchez, R Lopez-Lopez, L Rubio-Gordon, B Rosich-Del Cacho, L Tesouro-Rodriguez, M A Rivas-Paterna, M A Perez-Moneo Agapito, S Garcia-Garcia
AIM: To describe the clinical presentation, risk factors and complementary tests in patients of our paediatric emergency service with a final diagnosis of ischemic stroke. PATIENTS AND METHODS: Retrospective, analytical and observational study, performed in a Paediatric Emergency Service of a tertiary-level hospital. We included patients aged 1 month to 14 years during a 12-years period with a final diagnosis of ischemic cerebrovascular disease (CVD). We analyzed personal history, symptomatology and initial complementary tests...
April 16, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29643801/prevalence-of-and-risk-factors-for-cognitive-impairment-among-elderly-without-cardio-and-cerebrovascular-diseases-a-population-based-study-in-rural-china
#11
Li Ren, Lingling Bai, Yanan Wu, Jingxian Ni, Min Shi, Hongyan Lu, Jun Tu, Xianjia Ning, Ping Lei, Jinghua Wang
This study aimed to evaluate the prevalence of cognitive impairment and the distribution of its risk factors among residents aged ≥60 years without cardiovascular and cerebrovascular diseases in rural areas of northern China screened with the Chinese version of the Mini-Mental State Examination (MMSE). Between 2012 and 2013, a questionnaire survey was conducted to collect basic information from participants. Cognitive function was assessed using the MMSE. In the univariate analysis, risk factors for cognitive disorders were female sex, low education and central obesity, while drinking was found to be a protective factor...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29643080/periodic-limb-movements-during-sleep-in-stroke-tia-prevalence-course-and-cardiovascular-burden
#12
Mauro Manconi, Francesco Fanfulla, Raffaele Ferri, Silvia Miano, Josè Haba-Rubio, Raphael Heinzer, Thomas Horvath, Paola Proserpio, Peter Young, Giorgio Moschovitis, Andrea Seiler, Carlo Cereda, Lino Nobili, Roland Wiest, Sebastian R Ott, Claudio L Bassetti
OBJECTIVE: To define the prevalence, time course, and associated factors of periodic limb movements during sleep (PLMS) in patients with ischemic stroke or TIA. METHODS: Patients enrolled in the prospective Sleep-Disordered Breathing in Transient Ischemia Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy (SAS-CARE) study underwent a double polysomnographic investigation in the acute and chronic phases after stroke/TIA, together with a MRI brain scan and a 24-hour blood pressure evaluation...
April 11, 2018: Neurology
https://www.readbyqxmd.com/read/29629943/primary-aldosteronism-in-the-primary-care-setting
#13
Fabrizio Buffolo, Silvia Monticone, Martina Tetti, Paolo Mulatero
PURPOSE OF REVIEW: The aim of the present manuscript is to provide an overview of the most updated studies on the prevalence of primary aldosteronism in primary care and to compare these figures with the actual rate of diagnosis in clinical practice and with the prevalence of primary aldosteronism in specific subgroup of patients. RECENT FINDINGS: Over the last 20 years the clinical spectrum of low renin hypertension and primary aldosteronism has changed dramatically...
April 7, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29628949/safety-of-diagnostic-cerebral-and-spinal-digital-subtraction-angiography-in-a-developing-country-a-single-center-experience
#14
Qasim Bashir, Asim Ishfaq, Ammad Anwar Baig
Background: Digital subtraction angiography (DSA) remains the gold standard imaging modality for cerebrovascular disorders. In contrast to developed countries, the safety of the procedure is not extensively reported from the developing countries. Herein, we present a retrospective analysis of the basic technique, indications, and outcomes in 286 patients undergoing diagnostic cerebral and spinal angiography in a developing country, Pakistan. Methods: A retrospective review of patient demographics, procedural technique and complication rates of 286 consecutive patients undergoing the diagnostic cerebral/spinal angiography procedure at one institution from May 2013 to December 2015 was performed...
February 2018: Interventional Neurology
https://www.readbyqxmd.com/read/29627145/influence-of-hypoxia-induced-by-sleep-disordered-breathing-in-case-of-hypertension-and-atrial-fibrillation
#15
REVIEW
Shin-Ichi Ando
Sleep disordered breathing (SDB) has been recognized as one of the important causes or factors of worsening for various cerebro- and cardiovascular diseases. On the other hand, a recent large randomized study and meta-analysis about the effect of continuous positive airway pressure (CPAP) indicated no or only minor effects to improve the outcome of SDB patients. Accumulating evidence has indicated that the key factor of the link between SDB and cardiovascular diseases might be hypoxia caused during repetitive long apneic episodes...
April 4, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29623244/the-relationship-between-bone-mineral-density-and-cardiovascular-function-in-duchenne-muscular-dystrophy-a-retrospective-cohort-study
#16
Tara Kervin, Mathula Thangarajh
INTRODUCTION: Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder that causes progressive skeletal and cardiac muscle weakness in boys. Cardiac dysfunction is a frequent cause of death in DMD. Glucocorticoids are the standard of care in DMD. The long-term use of oral glucocorticoids in DMD is complicated by poor bone health. Epidemiological studies suggest a biological link between the loss of bone mineral density (BMD) and cardiovascular disease, including coronary artery and cerebrovascular diseases...
March 22, 2018: PLoS Currents
https://www.readbyqxmd.com/read/29618309/genetics-and-gene-therapy-of-anderson-fabry-disease
#17
Irene Simonetta, Antonino Tuttolomondo, Tiziana Di Chiara, Salvatore Miceli
Fabry's disease is a genetic disorder of X-linked inheritance caused by mutations in the alpha galactosidase A gene resulting in deficiency of this lysosomal enzyme. The progressive accumulation of glycosphingolipids, caused by the inadequate enzymatic activity, is responsible of organ dysfunction and thus of clinical manifestations. In presence of a high clinical suspicion, a careful physical examination and specific laboratory tests are required, finally diagnosis of Fabry's disease is confirmed by demonstration of absence or reduced alpha galactosidase A enzyme activity in hemizygous men and gene typing in heterozygous females; in fact the performance of enzymatic activity assay alone in women is inconclusive...
April 4, 2018: Current Gene Therapy
https://www.readbyqxmd.com/read/29614633/vascular-complications-of-sickle-cell-disease
#18
Ashar Usmani, Roberto F Machado
Sickle cell disease (SCD) is a monogenetic disorder caused by a mutation in the β-globin gene HBB leading to polymerization of red blood cells causing damage to cell membranes, increasing its rigidity and intravascular hemolysis. Multiple lines of evidence suggest that SCD can be viewed as pan-vasculopathy associated with multiple mechanisms but driven by hemoglobin S polymerization. Here we review the pathophysiology, clinical manifestations and management strategies for cerebrovascular disease, pulmonary hypertension and renal disease associated with SCD...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29605831/influence-of-sleep-disordered-breathing-assessed-by-pulse-oximetry-on-long-term-clinical-outcomes-in-patients-who-underwent-percutaneous-coronary-intervention
#19
Shoichiro Yatsu, Ryo Naito, Takatoshi Kasai, Hiroki Matsumoto, Jun Shitara, Megumi Shimizu, Azusa Murata, Takao Kato, Shoko Suda, Masaru Hiki, Eiryu Sai, Katsumi Miyauchi, Hiroyuki Daida
BACKGROUND: Sleep-disordered breathing (SDB) has been recognized as an important risk factor for coronary artery disease (CAD). However, SDB was not fully examined, because sleep studies are limited. Nocturnal pulse oximetry has been suggested to be a useful tool for evaluating SDB. Therefore, the aim of this study was to investigate the influence of SDB assessed by nocturnal pulse oximetry on clinical outcomes in patients who underwent percutaneous coronary intervention (PCI). METHODS: We conducted a prospective, multicenter, observational cohort study, wherein SDB was assessed by finger pulse oximetry in patients who underwent PCI from January 2014 to December 2016...
March 31, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29604980/imaging-studies-of-the-hiv-infected-brain
#20
Linda Chang, Dinesh K Shukla
Human immunodeficiency virus (HIV) enters the brain early after infecting humans and may remain in the central nervous system despite successful antiretroviral treatment. Many neuroimaging techniques were used to study HIV+ patients with or without opportunistic infections. These techniques assessed abnormalities in brain structures (using computed tomography, structural magnetic resonance imaging (MRI), diffusion MRI) and function (using functional MRI at rest or during a task, and perfusion MRI with or without a contrast agent)...
2018: Handbook of Clinical Neurology
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