keyword
https://read.qxmd.com/read/38049102/clinical-characteristics-of-children-with-combined-pituitary-hormone-deficiency-and-the-effects-of-growth-hormone-treatment
#1
JOURNAL ARTICLE
Özge Besci, Reyhan Deveci Sevim, Kübra Yüksek Acinikli, Korcan Demir, Gönül Çatlı, Bayram Özhan, Tolga Ünüvar, Ahmet Anık, Ayhan Abacı, Ayça Altıncık
AIM: We aimed to describe the clinical characteristics of patients with congenital combined pituitary hormone deficiency (CPHD) and evaluate the first-year growth responses of individuals with CPHD and isolated growth hormone deficiency (IGHD) in order to establish the influence of other hormone deficiencies on growth response. PATIENTS AND METHODS: This retrospective study was conducted in four tertiary care centers in Turkey. The records of patients diagnosed with CPHD (n=39) and severe IGHD (n=50) were collected...
December 4, 2023: Klinische Pädiatrie
https://read.qxmd.com/read/37987848/early-psychomotor-development-and-growth-hormone-therapy-in-children-with-prader-willi-syndrome-a-review
#2
REVIEW
Yu-Yu Jin, Fei-Hong Luo
Prader-Willi syndrome (PWS) is a rare genetic disorder caused by the loss of imprinted gene expression on the paternal chromosome 15q11-q13. PWS is characterized by varying degrees of early psychomotor developmental deficits, primarily in cognition, language, and motor development. This review summarizes the early mental cognitive development, language development, and motor development in patients with PWS, compares the correlation of genotype with phenotype, and provides an update regarding the effects and concerns related to potential main side effects of treatment with recombinant human growth hormone on early psycho-cognitive and motor function development along with the linear growth and body composition of children with PWS...
November 21, 2023: European Journal of Pediatrics
https://read.qxmd.com/read/37698649/late-effects-of-medulloblastoma-treatment-multidisciplinary-approach-of-survivors
#3
JOURNAL ARTICLE
Elif Habibe Aktekin, Meryem Özlem Kütük, Özlem Sangün, Nalan Yazıcı, Fatma Çaylaklı, İlknur Erol, Faik Sarıalioğlu
PURPOSE: Medulloblastoma is one of the brain tumors with increased life expectancy due to improvements in treatment approaches. Besides the promising results, various undesirable effects can be encountered. This study's aim is to review long-term follow-up outcomes of our cases with medulloblastoma. METHODS: Age at diagnosis, histological type of medulloblastoma, resection extension, chemotherapy and radiotherapy schemes, follow-up duration, and endocrinological, neuropsychiatric, cardiological, auditory, and visual examination results were evaluated in 20 patients diagnosed between 2007 and 2018 and followed 5 years and more...
September 12, 2023: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/37210269/growth-hormone-treatment-in-pediatrics-what-can-we-improve
#4
JOURNAL ARTICLE
Alicia Pérez-Pérez, Aroa Alonso Alonso, Andrea González García, Isolina Riaño Galán
OBJECTIVES: To analyze the age at which treatment with growth hormone (GH) is started in the different indications approved in our country, as well as to assess the response to it and detect points of improvement. MATERIAL AND METHODS: A descriptive, observational and retrospective study of pediatric patients receiving GH treatment in December 2020 and monitored in the pediatric Endocrinology Unit of a tertiary care hospital. RESULTS: A total of 111 patients (52 females) were included in the study...
May 18, 2023: Endocrinología, diabetes y nutrición
https://read.qxmd.com/read/36983870/malnutrition-patterns-in-children-with-chronic-kidney-disease
#5
REVIEW
Vasiliki Karava, John Dotis, Antonia Kondou, Nikoleta Printza
Malnutrition is frequent in children with chronic kidney disease (CKD). Apart from undernutrition and protein energy wasting (PEW), overnutrition prevalence is rising, resulting in fat mass accumulation. Sedentary behavior and unbalanced diet are the most important causal factors. Both underweight and obesity are linked to adverse outcomes regarding renal function, cardiometabolic risk and mortality rate. Muscle wasting is the cornerstone finding of PEW, preceding fat loss and may lead to fatigue, musculoskeletal decline and frailty...
March 6, 2023: Life
https://read.qxmd.com/read/36907727/evaluation-of-catch-up-growth-in-severe-pediatric-hashimoto-s-hypothyroidism
#6
JOURNAL ARTICLE
A Vincent, C Bouvattier, C Teinturier, D Rodrigue, K Busiah, I Olivier-Petit, H Bony, P Barat, B Cammas, R Coutant, A Lienhardt, A Linglart, A-S Lambert
BACKGROUND: We aimed to evaluate catch-up growth in children with severe Hashimoto's hypothyroidism (HH) after thyroid hormone replacement therapy (HRT). METHODS: A multicenter retrospective study was conducted including children referred for growth slowdown that led to the diagnosis of HH between 1998 and 2017. RESULTS: A total of 29 patients were included, with a median age of 9.7 years (13-172 months). Median height at diagnosis was -2...
March 10, 2023: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://read.qxmd.com/read/36843696/endocrine-abnormalities-in-children-with-traumatic-brain-injury-at-a-tertiary-care-center
#7
JOURNAL ARTICLE
Aaida Rao, Altaf Ali Laghari, Iman Bari, Muhammad Usman Khalid, Salman Kirmani, Muhammad Ehsan Bari
Objective Accidental traumatic brain injury (TBI) can lead to severe complications such as endocrine abnormalities and long-term morbidities and can negatively impact patient lives. These conditions are also associated with a high cost of treatment over a lifetime, a significant concern in low-to-middle-income countries (LMICs). In Pakistan, the prevalence of children with endocrine abnormalities secondary to TBI remains largely unexplored. We conducted a retrospective cross-sectional study to estimate the burden of endocrine abnormalities due to TBI among children in our population...
January 2023: Curēus
https://read.qxmd.com/read/36673021/an-approach-to-traumatic-brain-injury-related-hypopituitarism-overcoming-the-pediatric-challenges
#8
Raluca Maria Vlad, Alice Ioana Albu, Irina Delia Nicolaescu, Ruxandra Dobritoiu, Mara Carsote, Florica Sandru, Dragos Albu, Daniela Păcurar
Traumatic brain injury (TBI)-related hypopituitarism is a rare polymorphic complication of brain injury, with very little data, particularly concerning children and teenagers. This is a comprehensive review of the literature regarding this pathology, starting from a new pediatric case. The research was conducted on PubMed and included publications from the last 22 years. We identified nine original studies on the pediatric population (two case reports and seven studies; only four of these seven were prospective studies)...
January 6, 2023: Diagnostics
https://read.qxmd.com/read/36360345/endocrine-disorders-in-children-with-brain-tumors-at-diagnosis-after-surgery-radiotherapy-and-chemotherapy
#9
REVIEW
Fabien Claude, Graziamaria Ubertini, Gabor Szinnai
INTRODUCTION: Brain tumors are the second most frequent type of all pediatric malignancies. Depending on their localization, patients with brain tumors may present neurological or ophthalmological symptoms, but also weight anomalies and endocrine disorders ranging from growth hormone deficiency, anomalies of puberty, diabetes insipidus to panhypopituitarism. Immediately at diagnosis, all patients with brain tumors require a complete assessment of the hypothalamic-pituitary function in order to address eventual endocrine disorders...
October 25, 2022: Children
https://read.qxmd.com/read/36130625/pediatric-craniopharyngioma-the-effect-of-visual-deficits-and-hormone-deficiencies-on-long-term-cognitive-outcomes-after-conformal-photon-radiation-therapy
#10
JOURNAL ARTICLE
Thomas E Merchant, Sonal Dangda, Mary Ellen Hoehn, Shengjie Wu, Yimei Li, Fang Wang, Haitao Pan, Frederick A Boop, Niki Jurbergs, Heather M Conklin
PURPOSE: Pediatric patients with craniopharyngioma risk cognitive deficits when treated with radiation therapy. We investigated cognitive outcomes after conformal photon radiation therapy (CRT) and the effect of visual deficits and hormone deficiencies. METHODS AND MATERIALS: One hundred one pediatric patients were enrolled on a single institutional protocol beginning in 1998 (n = 76) or followed a similar nonprotocol treatment plan (n = 25)...
March 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/36067205/pre-and-postdiagnosis-growth-failure-adult-short-stature-and-untreated-growth-hormone-deficiency-in-radiotherapy-treated-long-term-survivors-of-childhood-brain-tumor
#11
JOURNAL ARTICLE
Julia Anttonen, Tiina Remes, Pekka Arikoski, Päivi Lähteenmäki, Mikko Arola, Arja Harila-Saari, Tuula Lönnqvist, Tytti Pokka, Pekka Riikonen, Kirsti Sirkiä, Heikki Rantala, Marja Ojaniemi
PURPOSE: Growth failure is common in radiotherapy-treated long-term survivors of pediatric brain tumors, but studies on longitudinal growth in this patient group are lacking. Here, the aim was to assess the changes in growth patterns before and after brain tumor diagnosis, the adult height, and the risk factors for compromised growth. The incidence and treatment practices of growth hormone deficiency were analyzed. METHODS: A cohort of 73 survivors of childhood brain tumor (median age 27...
2022: PloS One
https://read.qxmd.com/read/35995530/-delayed-growth-in-height-and-weight
#12
JOURNAL ARTICLE
Marine Delagrange, Thomas Édouard
Assessing weight and height development is a key element of pediatric follow-up. Growth retardation, even in isolation, may be the first symptom of a chronic disease and should therefore always be investigated. Many chronic diseases can be responsible and in most cases, diagnosis and management of the disease will minimize the impact on statural growth. The reconstruction of growth curves on the health record is essential to obtain a vision of the growth kinetics of the child and to orient the diagnosis. The study of the evolution of the ratio between weight and height is an essential point in the diagnostic process...
July 2022: Soins. Pédiatrie, Puériculture
https://read.qxmd.com/read/35770839/the-response-to-growth-hormone-treatment-in-a-child-with-short-stature-growth-hormone-deficiency-and-autosomal-dominant-cutis-laxa-type-3-case-report
#13
Mirela E Iancu, Alice I Albu, Dragoș N Albu
OBJECTIVES: The aetiology of short stature in cutis laxa (CL) syndromes is largely unknown. Herein, we report a case with autosomal dominant CL type 3 (ADCL3) with severe short stature and growth hormone (GH) deficiency. CASE PRESENTATION: A male patient with a genetically confirmed diagnosis of ADCL3 was referred for endocrinological evaluation of short stature at the age of 3.4 years. The examination revealed severe proportional short stature (-4.14 standard deviations (SD) score for height) in a patient born small for gestational age (birth weight 2080 g, -2...
July 1, 2022: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/35532626/long-term-outcomes-of-paediatric-onset-craniopharyngioma-a-retrospective-analysis-from-a-tertiary-care-centre-in-north-india
#14
JOURNAL ARTICLE
Gunna Sri Harsha, Preeti Dabadghao, Siddhnath Sudhanshu
Background: Craniopharyngiomas are associated with long-term morbidity in the form of hormone deficiencies, visual deficits, and hypothalamic obesity. Objective: To study the long-term outcomes, including cure rates, endocrine dysfunction, visual dysfunction, hypothalamic obesity, and mortality in pediatric-onset craniopharyngiomas. Methods: A retrospective data analysis of pediatric (onset <18 years) craniopharyngioma diagnosed between 2003 and 2018...
March 2022: Neurology India
https://read.qxmd.com/read/35466665/a-novel-pathogenic-igsf1-variant-in-a-patient-with-gh-and-tsh-deficiency-diagnosed-by-high-igf-i-values-at-transition-to-adult-care
#15
JOURNAL ARTICLE
Aslı Derya Kardelen, Esin Karakılıç Özturan, Şükran Poyrazoğlu, Firdevs Baş, Serdar Ceylaner, Sjoerd D Joustra, Jan M Wit, Feyza Darendeliler
IGSF1 deficiency is a rare X-linked condition characterized by central hypothyroidism (CeH) and a wide variety of other clinical features with variable prevalence, including a delayed pubertal testosterone rise and growth spurt in contrast to normal or accelerated testicular growth, and adult macroorchidism with relatively low serum testosterone concentrations. Other features include increased waist circumference, attention deficit, prolactin deficiency and transient partial growth hormone (GH) deficiency in childhood in contrast to an increased GH secretion in adulthood...
April 25, 2022: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/35086092/crk-haploinsufficiency-is-associated-with-intrauterine-growth-retardation-and-severe-postnatal-growth-failure
#16
Annalisa Deodati, Elena Inzaghi, Daniela Germani, Francesca Fausti, Stefano Cianfarani
BACKGROUND: Children with 17p13.3 microdeletions including the YWHAE gene show intrauterine growth restriction, craniofacial dysmorphisms, postnatal growth failure, and cognitive impairment. This region is characterized by genomic instability and has been associated with isolated lissencephaly sequence and Miller-Dieker syndrome characterized by facial dysmorphisms, microcephaly, short stature, seizures, cardiac malformations, and agyria. Whilst brain abnormalities are secondary to YWHAE deficiency, the cause of pre- and postnatal growth failure has not been identified yet...
January 27, 2022: Hormone Research in Pædiatrics
https://read.qxmd.com/read/34997199/testosterone-therapy-in-children-and-adolescents-to-whom-how-when
#17
REVIEW
Maria Camila Suarez A, Joseph M Israeli, Eliyahu Kresch, Leon Telis, Daniel E Nassau
Male production of testosterone is crucial for the development of a wide range of functions. External and internal genitalia formation, secondary sexual characteristics, spermatogenesis, growth velocity, bone mass density, psychosocial maturation, and metabolic and cardiovascular profiles are closely dependent on testosterone exposure. Disorders in androgen production can present during all life-stages, including childhood and adolescence, and testosterone therapy (TT) is in many cases the only treatment that can correct the underlying deficit...
January 7, 2022: International Journal of Impotence Research
https://read.qxmd.com/read/34902873/-effect-of-psychosocial-factors-on-growth
#18
JOURNAL ARTICLE
Bettina C Gohlke, Markus Bettendorf, Gerhard Binder, Berthold Hauffa, Thomas Reinehr, Helmuth-Guenther Dörr, Joachim Wölfle
BACKGROUND: Genes, hormones and factors such as nutrition and psychosocial environment affect growth. OBJECTIVE: What is the significance of various psychosocial factors on growth? METHODS: Evaluation of results of a working meeting of paediatric endocrinologist with current literature research. RESULTS: Psychosocial deprivation in children can be associated with growth hormone deficiency (GHD) and short stature. GHD can be reversed by a change of environment and psychosocial support...
March 2022: Klinische Pädiatrie
https://read.qxmd.com/read/34872636/growth-hormone-deficit-does-the-first-year-of-treatment-influence-adult-height
#19
JOURNAL ARTICLE
María José Sánchez Malo, Juan Hidalgo Sanz, Rebeca Hernández Abadía, Leire Arlabán Carpintero, Marta Ferrer Lozano, Jose Ignacio Labarta Aizpún, Antonio de Arriba Muñoz
INTRODUCTION: Short stature is the most frequent reason for Pediatric Endocrinology consultations and sometimes requires treatment with growth hormone. OBJECTIVE: The possible correlation of a good response to any early response factor with a better final response was studied, and also whether there was a difference in response to treatment according to the type of deficit. PATIENTS AND METHODS: This was a longitudinal, retrospective and observational study of 139 patients treated for idiopathic growth hormone deficiency up to adult height...
October 2021: Endocrinología, diabetes y nutrición
https://read.qxmd.com/read/34805044/floating-harbor-syndrome-treated-with-recombinant-human-growth-hormone-a-case-report-and-literature-review
#20
JOURNAL ARTICLE
Hui Bo, Lihong Jiang, Jiaqi Zheng, Jie Sun
Introduction: We aimed to summarize the clinical characteristics of Floating-Harbor syndrome (FHS) and the effect of recombinant human growth hormone (rhGH) to increase height. Methods: The clinical manifestations, gene sequencing results, treatment, and regression of one child with FHS were reported at the Department of Pediatrics, General Hospital of Tianjin Medical University, in July 2020. PubMed was searched using the keyword "Floating-Harbor Syndrome" up to March 2021 to obtain clinical information on children with FHS for review...
2021: Frontiers in Pediatrics
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