keyword
https://read.qxmd.com/read/38451126/role-of-neoadjuvant-chemotherapy-on-pathological-functional-and-survival-outcomes-of-upper-tract-urothelial-carcinoma-patients-a-systematic-review-and-meta-analysis
#21
JOURNAL ARTICLE
Abdalla Ali Deb, Pragnitha Chitteti, Naufal Naushad, Wael Asaad, Steve Leung, Alice Hartley, Hosam Serag
The role of neoadjuvant chemotherapy (NAC) in upper tract urothelial cancer (UTUC) is not yet confirmed. Therefore, we conducted this review to pool the available evidence in this regard. We analyzed 14117 UTUC patients reported in 21 studies after searching 5 databases. The NAC was administered in 1983 patients and the remaining 12134 controls underwent radical nephroureterectomy (RNU) alone. Efficacy endpoints included pathological, functional, and survival outcomes. Safety was determined by overall and grade 3-4 complications...
January 2024: Urol Res Pract
https://read.qxmd.com/read/38449987/a-case-of-duodenal-adenocarcinoma-effectively-highlighted-by-linked-color-imaging-and-confirmed-by-histopathology
#22
Kimitoshi Kubo, Xinhan Zhang, Ikko Tanaka, Noriko Kimura
While the differential diagnosis of duodenal adenocarcinoma versus adenoma remains the key to determining treatment strategies in patients with suspected duodenal adenocarcinoma, the role of linked color imaging (LCI) in their differential diagnosis remains insufficiently documented. In this case, esophagogastroduodenoscopy (EGD) was performed on a 67-year-old man for anemia, which revealed a 20-mm-sized, whitish, partially reddish, pedunculated lesion located in the duodenal bulb on white light imaging. Using LCI, the lesion was highlighted as a whitish, pedunculated lesion with its central and inferior areas depicted as orangish and reddish, respectively...
February 2024: Curēus
https://read.qxmd.com/read/38448362/management-after-local-excision-of-small-rectal-cancers-indications-for-completion-total-mesorectal-excision-and-possible-alternatives
#23
REVIEW
Camélia Labiad, Hadrien Alric, Maximilien Barret, Antoine Cazelles, Gabriel Rahmi, Mehdi Karoui, Gilles Manceau
The treatment of superficial rectal cancers (local excision, or proctectomy with total mesorectal excision (TME) remains controversial. Endoscopy and endorectal ultrasonography are essential for the precise initial definition of these small cancers. During endoscopy, the depth of the lesion can be estimated using virtual chromoendoscopy with magnification, thereby aiding the assessment of the possibilities of local excision. Current international recommendations indicate completion proctectomy after wide local excision for cases where the pathologic examination reveals poorly-differentiated lesions, lymphovascular invasion, grade 2 or 3 tumor budding, and incomplete resection...
March 5, 2024: Journal of Visceral Surgery
https://read.qxmd.com/read/38447254/saltt-study-a-retrospective-analysis-of-111-salivary-gland-tumors-of-lung-and-tracheobronchial-tree
#24
JOURNAL ARTICLE
Nishtha Batra, Prabhashankar Mishra, Trupti Pai, Sabita Jiwnani, George Karimundackal, Virendra Tiwari, Nilendu Purandare, Amit Janu, Vanita Noronha, Amit Joshi, Kumar Prabhash, Anil Tibdewal, Jai Prakash Agarwal, C S Pramesh, Rajiv Kumar Kaushal
INTRODUCTION: Primary pulmonary salivary gland-type tumours (PPSGT) are rare lung neoplasms arising from submucosal seromucinous glands in the central airway. METHODS AND RESULTS: We retrospectively analysed the clinicopathological features of 111 PPSGTs diagnosed at our institute between 2003 and 2021. The mean age at diagnosis was 43.8 years(range 6-78 years) and a male-to-female ratio of 2:1. On imaging, 92 % of cases had centrally located tumours and 37...
February 24, 2024: Annals of Diagnostic Pathology
https://read.qxmd.com/read/38446366/immunohistochemical-and-molecular-evaluation-of-tusc2-expression-in-breast-cancer
#25
JOURNAL ARTICLE
Leyla Tekin, Tuba Edgünlü, Deniz Genç
OBJECTIVE: Tumor suppressor candidate 2 has shown to be deleted in lung, colon, and bladder cancer types. In the present study, we aimed to investigate the expression of TUSC2 in breast cancer. MATERIALS AND METHODS: A total of thirty patients with breast cancer were included in the study. Normal and tumor tissue samples from fresh mastectomy materials were stored at -80 C until the number of cases was completed for gene expression analysis. Histopathological examination was carried out with routine hematoxylin & eosin method...
March 6, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38443256/who-would-be-the-winner-a-prognostic-nomogram-for-predicting-the-benefit-of-postoperative-radiotherapy%C3%A2-%C3%A2-%C3%A2-chemotherapy-in-patients-with-locally-advanced-gastric-cancer-trod-02-01-study
#26
JOURNAL ARTICLE
Fatma Sert, Ilknur Bilkay Gorken, Serdar Ozkok, Didem Colpan Oksuz, Birsen Yucel, Esra Kaytan Saglam, Gamze Aksu, Eren Cetin, Meryem Aktan, Emine Canyilmaz, Nilgün Ozbek Okumus, Berna Yildirim, Serap Akyurek, Meltem Serin, Meral Kurt, Zumre Arican Alicikus, Eda Erdis, Deniz Yalman
OBJECTIVES: We aimed to develop a basic, easily applicable nomogram to improve the survival prediction of the patients with stage II/III gastric cancer (GC) and to select the best candidate for postoperative radiotherapy (RT). METHODS: In this multicentric trial, we retrospectively evaluated the data of 1597 patients with stage II/III GC after curative gastrectomy followed by postoperative RT ± chemotherapy (CT). Patients were divided into a training set (n = 1307) and an external validation set (n = 290)...
March 4, 2024: Asian Journal of Surgery
https://read.qxmd.com/read/38441175/cellular-senescence-in-testicular-cancer-is-there-a-correlation-with-the-preoperative-markers-and-the-extent-of-the-tumor-an-experimental-study
#27
JOURNAL ARTICLE
Vasileios Tatanis, Dimitris Veroutis, Pavlos Pantelis, George Theocharous, Helen Sarlanis, Alexandros Georgiou, Angelis Peteinaris, Anastasios Natsos, Napoleon Moulavasilis, Nikolaos Kavantzas, Athanassios Kotsinas, Ioannis Adamakis
PURPOSE: The aim of this experimental study is to investigate the correlation between the presence of senescent cells and the tumor size, the lymphovascular invasion (LVI), the invasion of rete testis (RTI), the preoperative tumor markers or pathological stage in patients who underwent orchiectomy for malignant purposes. METHODS: This experimental study included patients with a history of radical orchiectomy performed from January 2011 to January 2019. The testicular tissue specimens underwent an immunohistopathological process for the detection of the presence of cellular senescence...
March 4, 2024: Archivio Italiano di Urologia, Andrologia
https://read.qxmd.com/read/38440966/a-novel-predictive-model-of-lymphovascular-space-invasion-in-early-stage-endometrial-cancer
#28
JOURNAL ARTICLE
İbrahim Taşkum, Muhammed Hanifi Bademkıran, Furkan Çetin, Seyhun Sucu, Erkan Yergin, Özcan Balat, Halil Özkaya, Evren Uzun
OBJECTIVE: To predict lymphovascular space invasion (LVSI) positivity in early-stage (stage 1-2) endometrial cancer (EC) using a predictive model with prognostic factors of EC. MATERIALS AND METHODS: We included 461 patients who underwent total hysterectomy and bilateral salpingo-oophorectomy with pelvic-paraaortic lymphadenectomy as the primary treatment for presumed early-stage EC at our clinic between 2010 and 2020. Moreover, all surgical specimens were examined histopathologically for the positivity or negativity of LVSI, and the patients were divided into two groups based on these pathologic outcomes...
March 4, 2024: Turkish Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38438216/papillary-thyroid-microcarcinoma-with-and-without-nodal-metastasis-a-comparative-analysis
#29
JOURNAL ARTICLE
Saleh Alqaryan, Hisham Almousa, Raed Almutairi, Ahmed Altuwaijri, Aseel Doubi, Zuhour Alqahtani, Mohammad Almayouf, Majed Albarrak, Mohammed Alessa, Saleh Aldhahri, Khalid Alqahtani
OBJECTIVES: To assess the demographics and clinical factors of papillary thyroid microcarcinoma (PTMC) patients in Saudi Arabia and compared and analyzed the differences between the patients with and without lymph node metastasis (LNM). Papillary thyroid microcarcinoma (PTMC) is a common thyroid cancer and is not usually detectable clinically but found incidentally after pathologic evaluation of thyroid tissue following surgery for benign thyroid disorders. However, these tumors have a significant risk of LNM...
March 2024: Saudi Medical Journal
https://read.qxmd.com/read/38433382/lymphatic-expression-of-the-proliferation-marker-ki67-is-linked-to-sentinel-node-positivity-recurrence-and-mortality-in-primary-cutaneous-melanoma
#30
JOURNAL ARTICLE
Samuel X Tan, Sharene Chong, Casey Rowe, Jack Galbraith, James Dight, Chenhao Zhou, Maryrose Malt, Bernard Mark Smithers, Kiarash Khosrotehrani
Lymphangiogenesis is a precursor to lymphovascular invasion, and may therefore signal a higher risk of metastasis and mortality in primary cutaneous melanoma. This retrospective longitudinal study aimed to evaluate whether emergent lymphangiogenesis, as measured through co-expression of endothelial proteins with the proliferation marker Ki67, was associated with poorer prognosis in a cohort of patients with single primary cutaneous melanoma. We screened all patients with a single locally invasive primary cutaneous melanoma who received sentinel lymph node biopsy at a tertiary dermatology centre in Brisbane, Australia between 1994 and 2007...
March 2024: Experimental Dermatology
https://read.qxmd.com/read/38433140/prognostic-factors-of-oral-squamous-cell-carcinoma-the-importance-of-recurrence-and-ptnm-stage
#31
JOURNAL ARTICLE
Min Jae Kim, Kang-Min Ahn
BACKGROUND: Oral squamous cell carcinoma has a poor prognosis. Therefore, prognostic factors are important to increase the survival rate. This study assessed the survival rate and the prognostic factors for survival of patients with oral squamous cell carcinoma. METHOD: This study included 168 patients who underwent surgery for oral squamous cell carcinoma between January 2006 and December 2021. The survival rate was analyzed with overall survival and disease-specific survival...
March 4, 2024: Maxillofacial Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38432859/comparative-study-of-tumor-free-laparoscopic-and-open-surgery-in-the-treatment-of-early-stage-cervical-cancer
#32
JOURNAL ARTICLE
Jing Zhao, Qiao Liu, Dan Jiang, Tianmin Chen, Shengjun Meng, Chuqiang Shu
OBJECTIVES: Laparoscopic surgery for cervical cancer has the advantages of little blood loss and rapid recovery, but its therapeutic effect is still controversial. This study aims to analyze the surgical procedure and clinical efficacy of tumor-free laparoscopic radical hysterectomy without a uterine manipulator for early-stage cervical cancer, and to explore the indications of laparoscopic surgery for cervical cancer. METHODS: This study was a retrospective study...
November 28, 2023: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://read.qxmd.com/read/38431107/long-term-outcomes-of-endoscopic-resection-for-well-differentiated-nonampullary-duodenal-neuroendocrine-tumors
#33
JOURNAL ARTICLE
Yun Wang, Zhong Ren, Yue-Hong Shen, Xi-Guo Fang, Quan-Lin Li, Yun-Shi Zhong, Yi-Qun Zhang, Wei-Feng Chen, Ping-Hong Zhou, Sheng-Li Lin
BACKGROUND & AIMS: Nonampullary duodenal neuroendocrine tumors (NAD-NETs) are rare with limited evidence regarding endoscopic treatment. The study aimed to investigate the efficacy and safety of endoscopic resection of well-differentiated NAD-NETs and evaluate long-term outcomes, including local recurrence and metastasis. METHODS: A total of 78 patients with NAD-NETs who underwent endoscopic resection between January 2011 and August 2022 were included. The clinicopathologic characteristics and treatment outcomes were collected and analyzed...
February 29, 2024: Gastrointestinal Endoscopy
https://read.qxmd.com/read/38430702/lymph-node-metastases-are-more-frequent-in-paediatric-appendiceal-net-%C3%A2-1-5%C3%A2-cm-but-without-impact-on-outcome-data-from-the-german-met-studies
#34
JOURNAL ARTICLE
Michaela Kuhlen, Marina Kunstreich, Ulrich-Frank Pape, Guido Seitz, Lienhard Lessel, Christian Vokuhl, Michael C Frühwald, Peter Vorwerk, Antje Redlich
BACKGROUND: Paediatric appendiceal neuroendocrine tumours (appNET) are very rare tumours, mostly detected incidentally by histopathological evaluation after appendectomy. Treatment recommendations are based on adult data considering high-risk NET as defined by European Neuroendocrine Tumour Society (ENETS) guidelines for completion right-sided hemicolectomy (RHC). Recent data suggest that less aggressive therapy may be justified. PROCEDURE: Analysis of children and adolescents with appNET prospectively registered with the German Malignant Endocrine Tumour (MET) studies between 1997 and 2022...
February 27, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38428409/pdgfr%C3%AE-itga11-fibroblasts-foster-early-stage-cancer-lymphovascular-invasion-and-lymphatic-metastasis-via-itga11-sele-interplay
#35
JOURNAL ARTICLE
Hanhao Zheng, Mingjie An, Yuming Luo, Xiayao Diao, Wenlong Zhong, Mingrui Pang, Yan Lin, Jiancheng Chen, Yuanlong Li, Yao Kong, Yue Zhao, Yina Yin, Le Ai, Jian Huang, Changhao Chen, Tianxin Lin
Cancer-associated fibroblasts (CAFs) exhibit considerable heterogeneity in advanced cancers; however, the functional annotation and mechanism of CAFs in early-stage cancers remain elusive. Utilizing single-cell RNA sequencing and spatial transcriptomic, we identify a previously unknown PDGFRα+ ITGA11+ CAF subset in early-stage bladder cancer (BCa). Multicenter clinical analysis of a 910-case cohort confirms that PDGFRα+ ITGA11+ CAFs are associated with lymphovascular invasion (LVI) and poor prognosis in early-stage BCa...
February 23, 2024: Cancer Cell
https://read.qxmd.com/read/38427584/an-ultrasound-based-nomogram-for-predicting-axillary-node-pathologic-complete-response-after-neoadjuvant-chemotherapy-in-breast-cancer-modeling-and-external-validation
#36
JOURNAL ARTICLE
Qijun Zheng, Huicui Yan, Yingjian He, Jiwei Wang, Nan Zhang, Ling Huo, Yiqiang Liu, Lize Wang, Ling Xu, Zhaoqing Fan
INTRODUCTION: The staging and treatment of axillary nodes in breast cancer have become a focus of research. For breast cancer patients with fine-needle aspiration-or core needle biopsy-confirmed positive nodes, axillary lymph node dissection (ALND) after neoadjuvant chemotherapy (NAC) is still a standard treatment. However, some patients achieve an axillary pathologic complete response (pCR) after NAC. In this study, the authors sought to construct a model to predict axillary pCR in patients with positive axillary lymph nodes (cN+) breast cancer...
March 1, 2024: Cancer
https://read.qxmd.com/read/38423947/correlation-between-quantitative-parameters-obtained-by-dual-energy-spectral-ct-and-prognostic-histopathological-factors-and-biomarkers-in-breast-cancer
#37
JOURNAL ARTICLE
Nurgül Orhan Metin, Sinan Balcı, Yavuz Metin, Filiz Taşçı, Melih Gaffar Gözükara
RATIONALE AND OBJECTIVES: To investigate the correlation between quantitative parameters obtained by dual energy spectral computed tomography (DESCT) and various histopathological factors and biomarkers associated with the prognosis of breast cancer. MATERIALS AND METHODS: Quantitative parameters such as iodine content (IC), normalized IC (nIC), iodine enhancement (IE) and normalized IE (nIE) were measured on virtual monochromatic images and iodine mapping images obtained from DESCT in 116 female breast cancer patients...
February 1, 2024: Clinical Breast Cancer
https://read.qxmd.com/read/38418345/photon-counting-computed-tomography-in-rectal-cancer-associations-between-iodine-concentration-histopathology-and-treatment-response-a-pilot-study
#38
JOURNAL ARTICLE
Alexey Surov, Raihanatou Diallo-Danebrock, Amin Radi, Jan Robert Kröger, Julius Henning Niehoff, Arwed Elias Michael, Berthold Gerdes, Saleem Elhabash, Andreas Wienke, Jan Borggrefe
RATIONALE AND OBJECTIVES: Common computed tomography (CT) investigation plays a limited role in characterizing and assessing the response of rectal cancer (RC) to neoadjuvant radiochemotherapy (NARC). Photon counting computed tomography (PCCT) improves the imaging quality and can provide multiparametric spectral image information including iodine concentration (IC). Our purpose was to analyze associations between IC and histopathology in RC and to evaluate the role of IC in response prediction to NARC...
February 27, 2024: Academic Radiology
https://read.qxmd.com/read/38410339/clinical-characteristics-and-management-of-triple-negative-breast-cancer-tnbc-in-jordan-a-retrospective-analysis
#39
JOURNAL ARTICLE
Hussein Al Husban, Anas Al Rabadi, Ala H Odeh, Kahled Abu Rumman, Feras Alkhawaldeh, Haneen Noures, Mohammad Abo Ashoor, Anas Abu Rumman, Mousa Atmeh, Mohannad Bawaneh
Introduction Triple-negative breast cancer (TNBC) is known for its aggressive nature and poor prognosis. Despite its responsiveness to chemotherapy, TNBC presents challenges in terms of survival, recurrence, and mortality rates, particularly in diverse populations. Limited research in the Middle East hampers comprehensive understanding and tailored management. Methods A retrospective study at the King Hussein Medical Center in Jordan between the period 2009 to 2023 explored TNBC patients (n=110) who underwent adjuvant chemotherapy after local excision or modified radical mastectomy (MRM)...
January 2024: Curēus
https://read.qxmd.com/read/38409841/the-role-of-lymphovascular-space-invasion-and-cytology-in-the-prognosis-of-endometrial-cancer
#40
JOURNAL ARTICLE
Cem Yagmur Ozdemir, Dagistan Tolga Arioz, Fatih Celik, Nayif Cicekli, Mariam Chkhikvadze, Filiz Bilir, Sezgin Yılmaz, Nefize Vatansever
BACKGROUND: Lymphovascular space invasion (LVSI) and cytology are both independent and strong prognostic factors in endometrial cancer. This study aims to highlight the impact of LVSI and cytology positivity on prognosis, in addition to molecular classification. METHODS: A retrospective review was conducted on the records of 223 patients with endometrial cancer diagnosed between January 2011 and January 2021. The inclusion criteria stipulated that the patients were diagnosed with endometrial cancer by endometrial biopsy and were operated in the clinic...
February 2024: Discovery Medicine
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