keyword
https://read.qxmd.com/read/38492996/assessment-of-postmastectomy-radiation-therapy-receipt-by-age-and-association-with-outcomes-in-women-with-breast-cancer
#1
JOURNAL ARTICLE
Carolina E Fasola, Elaina Graham, Wei Sha, Courtney R Schepel, Sally J Trufan, Anna Hecksher, Richard L White, Lejla Hadzikadic-Gusic
PURPOSE: Postmastectomy radiation therapy (PMRT) reduces locoregional recurrence (LRR) and improves overall survival (OS) in patients with breast cancer. Young age has been recognized as a risk factor for LRR. The primary objective of this study was to determine if recommendations for PMRT differed among patients younger than 50 years as compared to women aged 50 years or older. METHODS: We reviewed medical records of patients with breast cancer who underwent mastectomy with or without PMRT from 2010 through 2018...
February 28, 2024: Clinical Breast Cancer
https://read.qxmd.com/read/38490840/machine-learning-radiomics-based-prediction-of-non-sentinel-lymph-node-metastasis-in-chinese-breast-cancer-patients-with-1-2-positive-sentinel-lymph-nodes-a-multicenter-study
#2
JOURNAL ARTICLE
Guihan Lin, Weiyue Chen, Yingying Fan, Yi Zhou, Xia Li, Xin Hu, Xue Cheng, Mingzhen Chen, Chunli Kong, Minjiang Chen, Min Xu, Zhiyi Peng, Jiansong Ji
RATIONALE AND OBJECTIVES: This study aimed to construct a machine learning radiomics-based model using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) images to evaluate non-sentinel lymph node (NSLN) metastasis in Chinese breast cancer (BC) patients who underwent total mastectomy (TM) and had 1-2 positive sentinel lymph nodes (SLNs). MATERIALS AND METHODS: In total, 494 patients were retrospectively enrolled from two hospitals, and were divided into the training (n = 286), internal validation (n = 122), and external validation (n = 86) cohorts...
March 14, 2024: Academic Radiology
https://read.qxmd.com/read/38487119/peritoneal-recurrence-of-squamous-cell-carcinoma-in-a-young-woman-after-conization-for-microinvasive-cervical-cancer
#3
Isao Otsuka
Microinvasive squamous cell carcinoma of the cervix develops mainly in young women. As metastases rarely occur, cervical conization to preserve fertility is often performed. We report a case of peritoneal recurrence developed after conization. A 31-year-old nulligravid woman with microinvasive squamous cell carcinoma of the cervix was treated with laser conization. Pathology showed a stromal invasion of <1 mm and a longitudinal spread of 3 mm without lymphovascular space involvement. Forty-seven months after conization, a pelvic examination revealed a firm, immobile mass on the right side of the pelvis...
February 2024: Curēus
https://read.qxmd.com/read/38485222/comparative-study-using-indocyanine-green-and-patent-blue-dye-for-sentinel-lymph-node-biopsy-in-patients-with-early-stage-cervical-cancer
#4
JOURNAL ARTICLE
Benedikt Wess, Christhardt Kohler, Andrea Plaikner, Samer El-Safadi, Thilo Schwandner, Ivo Meinhold-Heerlein, Giovanni Favero
ACKGROUND: Lymphatic involvement is the most important prognostic factor in early-stage cervical cancer. Sentinel lymph node biopsy is a viable alternative to systematic lymphadenectomy and may identify metastases more precisely. OBJECTIVE: To compare two tracers (indocyanine green and patent blue) to detect sentinel nodes. METHODS: A single-center, retrospective study of women treated due to early-stage cervical cancer (International Federation of Gynecology and Obstetrics 2009 IA1 with lymphovascular invasion, IA2, and IB1)...
March 14, 2024: International Journal of Gynecological Cancer
https://read.qxmd.com/read/38484492/risk-factors-for-pelvic-and-para-aortic-lymph-node-metastasis-in-non-endometrioid-endometrial-cancer
#5
JOURNAL ARTICLE
Yi Sun, Yuanpei Wang, Xiaoran Cheng, Weijia Wu, Qianwen Liu, Xuerou Chen, Fang Ren
PURPOSE: The aim of this study was to evaluate the risk factors for pelvic lymph node metastasis (LNM) and para-aortic LNM in non-endometrioid endometrial cancer (non-EEC). METHODS: A total of 283 patients with non-EEC hospitalized in the First Affiliated Hospital of Zhengzhou University from January 2012 to December 2020 were included. Various characteristics were retrospectively analyzed in relation to LNM. RESULTS: Univariable and multivariable logistic regression analysis revealed cervical stromal invasion (OR = 3...
March 8, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38483586/prognostic-factors-among-patients-with-pathological-grade-group-5-prostate-cancer-based-on-robot-associated-radical-prostatectomy-specimens-from-a-large-japanese-cohort-msug94
#6
JOURNAL ARTICLE
Takeshi Sasaki, Shin Ebara, Tomoyuki Tatenuma, Yoshinori Ikehata, Akinori Nakayama, Makoto Kawase, Masahiro Toide, Tatsuaki Yoneda, Kazushige Sakaguchi, Jun Teishima, Kazuhide Makiyama, Hiroshi Kitamura, Kazutaka Saito, Takuya Koie, Fumitaka Koga, Shinji Urakami, Takahiro Inoue
PURPOSE: There are no definitive prognostic factors for patients with pathological Grade Group 5 (pGG 5) prostate cancer (PCa) undergoing robot-associated radical prostatectomy (RARP). This study aimed to explore the prognostic factors among patients with pGG 5 PCa in a large Japanese cohort (MSUG94). METHODS: This retrospective, multi-institutional cohort study was conducted between 2012 and 2021 at ten centers in Japan and included 3195 patients. Patients with clinically metastatic PCa (cN1 or cM1) and those receiving neoadjuvant and/or adjuvant therapy were excluded...
March 14, 2024: World Journal of Urology
https://read.qxmd.com/read/38482915/patterns-and-trends-in-adjuvant-therapy-for-major-salivary-gland-cancer
#7
JOURNAL ARTICLE
Aman M Patel, Afash Haleem, Hassaam S Choudhry, Roman Povolotskiy, Dylan F Roden
OBJECTIVE: To investigate adjuvant therapy indications, utilization, and associated survival disparities in major salivary gland cancer (MSGC). STUDY DESIGN: Retrospective cohort study. SETTING: The 2006 to 2017 National Cancer Database. METHODS: Patients with surgically resected MSGC were included (N = 11,398). pT3-4 classification, pN2-3 classification, lymphovascular invasion, pathologic extranodal extension (pENE), and positive surgical margin (PSM) were considered indications for adjuvant radiotherapy (aRT)...
March 14, 2024: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/38480561/solid-pseudopapillary-tumor-of-the-pancreas-is-enucleation-safe
#8
JOURNAL ARTICLE
Oscar Salirrosas, Eduardo A Vega, Elena Panettieri, Hamed Harandi, Olga Kozyreva, Shree Ghanta, Claudius Conrad
BACKGROUND: While solid pseudopapillary tumor (SPT) of the pancreas are oncologically low-risk tumors, their resection with pancreaticoduodenectomy (PD) or partial pancreatectomy (PP) carries a significant risk for morbidity. To balance the favorable prognosis with the surgical morbidity of pancreas resection, this study explores the oncologic safety of enucleation (EN). PATIENTS AND METHODS: The National Cancer Database (NCDB) was queried for resected SPT from January 2004 through December 2020...
March 13, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38479623/endoscopic-submucosal-dissection-for-early-esophageal-adenocarcinoma-low-rates-of-metastases-in-mucosal-cancers-with-poor-differentiation
#9
JOURNAL ARTICLE
Andreas Probst, Felix Kappler, Alanna Ebigbo, David Albers, Siegbert Faiss, Ingo Steinbrück, Andreas Wannhoff, Hans-Peter Allgaier, Ulrike Denzer, Viktor Rempel, Roland Reinehr, Dani Dakkak, Matthias Mende, Jürgen Pohl, Tina Schaller, Bruno Märkl, Anna Muzalyova, Carola Fleischmann, Helmut Messmann
BACKGROUND AND AIMS: Endoscopic resection (ER) is accepted as standard treatment for intramucosal esophageal adenocarcinoma (EAC) with well or moderate differentiation. Poor differentiation (PD) is judged as a risk factor for lymph node metastasis (LNM) and surgery is recommended. However, the evidence for this recommendation is weak. Study aim was to analyze the clinical course of patients after ER of EAC with PD. PATIENTS AND METHODS: Patients undergoing endoscopic submucosal dissection for EAC were included from 16 German centers...
March 11, 2024: Gastrointestinal Endoscopy
https://read.qxmd.com/read/38476798/a-comprehensive-retrospective-institutional-study-for-decoding-oral-squamous-cell-carcinoma
#10
JOURNAL ARTICLE
Prathiba Reichal, Roland Prethipa
Background Oral cancer is found to be the thirteenth most common cancer as stated by the WHO (World Health Organization 2023). Oral squamous cell carcinoma (OSCC) is associated with deleterious oral habits such as smoking, chewing tobacco and betel quid, alcohol consumption, low socioeconomic status, sharp teeth, and various causative factors. Materials and methods A three-year retrospective analysis (March 2020-September 2023) was carried out with the available patient records in the Dental Information Archival Software (DIAS) used in a private dental college in Chennai...
February 2024: Curēus
https://read.qxmd.com/read/38473340/prognostic-implication-of-lymphovascular-invasion-in-early-gastric-cancer-meeting-endoscopic-submucosal-dissection-criteria-insights-from-radical-surgery-outcomes
#11
JOURNAL ARTICLE
Bo Sun, Huanhuan Li, Xiaodong Gu, Hong Cai
BACKGROUND: The management of early gastric cancer (EGC) has witnessed a rise in the utilization of endoscopic submucosal dissection (ESD) as a treatment modality, although prognostic markers are needed to guide management strategies. This study investigates the prognostic implications of lymphovascular invasion (LVI) in ESD-eligible EGC patients, specifically its implications for subsequent radical surgery. MATERIAL AND METHODS: A retrospective, multicenter study from two primary hospitals analyzed clinicopathological data from 1369 EGC patients eligible for ESD, who underwent gastrectomy at Shanghai Cancer Center and Huashan Hospital between 2009 and 2018...
February 28, 2024: Cancers
https://read.qxmd.com/read/38473287/association-of-lymphovascular-invasion-with-lymph-node-metastases-in-prostate-cancer-lateralization-concept
#12
JOURNAL ARTICLE
Jakub Karwacki, Adam Gurwin, Arkadiusz Jaworski, Michał Jarocki, Marcel Stodolak, Andrzej Dłubak, Przemysław Szuba, Artur Lemiński, Krystian Kaczmarek, Agnieszka Hałoń, Tomasz Szydełko, Bartosz Małkiewicz
BACKGROUND: Lymphovascular invasion (LVI) is a vital but often overlooked prognostic factor in prostate cancer. As debates on lymphadenectomy's overtreatment emerge, understanding LVI laterality gains importance. This study pioneers the investigation into PCa, aiming to uncover patterns that could influence tailored surgical strategies in the future. METHODS: Data from 96 patients with both LVI and lymph node invasion (LNI) were retrospectively analyzed. All participants underwent radical prostatectomy (RP) with modified-extended pelvic lymph node dissection (mePLND)...
February 25, 2024: Cancers
https://read.qxmd.com/read/38471960/fully-automated-identification-of-lymph-node-metastases-and-lymphovascular-invasion-in-endometrial-cancer-from-multi-parametric-mri-by-deep-learning
#13
JOURNAL ARTICLE
Yida Wang, Wei Liu, Yuanyuan Lu, Rennan Ling, Wenjing Wang, Shengyong Li, Feiran Zhang, Yan Ning, Xiaojun Chen, Guang Yang, He Zhang
BACKGROUND: Early and accurate identification of lymphatic node metastasis (LNM) and lymphatic vascular space invasion (LVSI) for endometrial cancer (EC) patients is important for treatment design, but difficult on multi-parametric MRI (mpMRI) images. PURPOSE: To develop a deep learning (DL) model to simultaneously identify of LNM and LVSI of EC from mpMRI images. STUDY TYPE: Retrospective. POPULATION: Six hundred twenty-one patients with histologically proven EC from two institutions, including 111 LNM-positive and 168 LVSI-positive, divided into training, internal, and external test cohorts of 398, 169, and 54 patients, respectively...
March 12, 2024: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38469021/gastric-adenocarcinoma-with-unusual-clear-tubulopapillary-morphology-a-case-report
#14
Nadir Miry, Younesse Najioui, Anass Haloui, Nassira Karich, Amal Bennani
Gastric clear cell adenocarcinoma is an extremely rare variant of papillary adenocarcinoma of the stomach. It is associated with a poor prognosis due to its frequent lymphovascular invasion and also its higher risk of recurrence. It is characterized morphologically by a clear appearance of tumor cells, which can be easily confused with a metastasis of a clear cell carcinoma, particularly of renal origin. Very few cases have been previously reported in the literature, which makes it a very poorly known variant...
February 2024: Curēus
https://read.qxmd.com/read/38467265/prediction-of-lymphovascular-invasion-status-in-breast-cancer-based-on-magnetic-resonance-imaging-radiomics-features
#15
JOURNAL ARTICLE
Xinhua Li, Kangwei Luo, Na Zhang, Wubiao Chen, Bin Li, Zhendong Lu, Yixian Chen, Kangwei Wu
OBJECTIVE: This study intended to investigate the feasibility and effectiveness of using clinical magnetic resonance imaging (MRI) radiomics features to predict lymphovascular invasion (LVI) status in breast cancer (BC) patients. METHODS: A total of 182 BCE patients were retrospectively collected and randomly divided into a training set (n = 127) and a validation set (n = 55) in a 7:3 ratio. Based on pathological examination results, the training set was further divided into LVI group (n = 60) and non-LVI group (n = 67), and the validation set was divided into LVI group (n = 24) and non-LVI group (n = 31)...
March 9, 2024: Magnetic Resonance Imaging
https://read.qxmd.com/read/38463232/overexpression-of-circulating-cd38-nk-cells-in-colorectal-cancer-was-associated-with-lymph-node-metastasis-and-poor-prognosis
#16
JOURNAL ARTICLE
Xueling Wang, Haoran Li, Huixian Chen, Kehua Fang, Xiaotian Chang
INTRODUCTION: Lymph node metastasis (LNM) is a critical prognostic factor for colorectal cancer (CRC). Due to the potential influence of immune system on CRC progression, investigation into lymphocyte subsets as clinical markers has gained attention. The objective of this study was to assess the capability of lymphocyte subsets in evaluating the lymph node status and prognosis of CRC. METHODS: Lymphocyte subsets, including T cells (CD3+), natural killer cells (NK, CD3- CD56+), natural killer-like T cells (NK-like T, CD3+ CD56+), CD38+ NK cells (CD3- CD56+ CD38+) and CD38+ NK-like T cells (CD3+ CD56+ CD38+), were detected by flow cytometry...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38463023/preoperative-prediction-of-lymphovascular-and-perineural-invasion-in-gastric-cancer-using-spectral-computed-tomography-imaging-and-machine-learning
#17
JOURNAL ARTICLE
Hui-Ting Ge, Jian-Wu Chen, Li-Li Wang, Tian-Xiu Zou, Bin Zheng, Yuan-Fen Liu, Yun-Jing Xue, Wei-Wen Lin
BACKGROUND: Lymphovascular invasion (LVI) and perineural invasion (PNI) are important prognostic factors for gastric cancer (GC) that indicate an increased risk of metastasis and poor outcomes. Accurate preoperative prediction of LVI/PNI status could help clinicians identify high-risk patients and guide treatment decisions. However, prior models using conventional computed tomography (CT) images to predict LVI or PNI separately have had limited accuracy. Spectral CT provides quantitative enhancement parameters that may better capture tumor invasion...
February 14, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38458186/unraveling-a-hidden-player-in-lymphovascular-invasion-in-bladder-cancer
#18
JOURNAL ARTICLE
Benjamin Wolf, Rakesh K Jain
Tumor invasion into the lymphatic vasculature represents a critical step during malignant progression of epithelial cancers. In this issue of Cancer Cell, Zheng et al. unravel how cancer-associated fibroblasts interact with lymphatic endothelial cells and the extracellular matrix to promote lymphatic tumor invasion and suggest that these processes could be treatment targets.
March 6, 2024: Cancer Cell
https://read.qxmd.com/read/38455507/survivin-expression-is-associated-with-lymph-node-metastasis-and-short-survival-in-patients-with-colorectal-adenocarcinoma
#19
JOURNAL ARTICLE
Haneen Al-Maghrabi, Zuhoor Al-Mansouri, Jaudah Al-Maghrabi
BACKGROUND: Survivin, a protein belonging to the Inhibitor of apoptosis (IAP) family, is the smallest member in terms of size. It works by preventing programmed cell death and regulating the advancement of the cell cycle. Being a part of the group of inhibitors associated with apoptosis, survivin is connected to increased aggression and negative prognosis in different malignancies, including colorectal cancer (CRC). MATERIALS AND METHODS: Pathology tissue blocks of 209 primary tumors, and 44 adenomas, were used in this study, as well as an anti-Survivin antibody...
2024: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/38452438/prognostic-value-of-histopathologic-traits-independent-of-stromal-tumor-infiltrating-lymphocyte-levels-in-chemotherapy-na%C3%A3-ve-patients-with-triple-negative-breast-cancer
#20
JOURNAL ARTICLE
L W de Boo, K Jóźwiak, N D Ter Hoeve, P J van Diest, M Opdam, Y Wang, M K Schmidt, V de Jong, S Kleiterp, S Cornelissen, D Baars, R H T Koornstra, E D Kerver, T van Dalen, A D Bins, A Beeker, S M van den Heiligenberg, P C de Jong, S D Bakker, R C Rietbroek, I R Konings, R Blankenburgh, R M Bijlsma, A L T Imholz, N Stathonikos, W Vreuls, J Sanders, E H Rosenberg, E A Koop, Z Varga, C H M van Deurzen, A L Mooyaart, A Córdoba, E Groen, J Bart, S M Willems, V Zolota, J Wesseling, A Sapino, E Chmielik, A Ryska, A Broeks, A C Voogd, E van der Wall, S Siesling, R Salgado, G M H E Dackus, M Hauptmann, M Kok, S C Linn
BACKGROUND: In the absence of prognostic biomarkers, most patients with early-stage triple-negative breast cancer (eTNBC) are treated with combination chemotherapy. The identification of biomarkers to select patients for whom treatment de-escalation or escalation could be considered remains an unmet need. We evaluated the prognostic value of histopathologic traits in a unique cohort of young, (neo)adjuvant chemotherapy-naïve patients with early-stage (stage I or II), node-negative TNBC and long-term follow-up, in relation to stromal tumor-infiltrating lymphocytes (sTILs) for which the prognostic value was recently reported...
March 6, 2024: ESMO Open
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