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JOURNAL ARTICLE
Thomas Thisted, F Donelson Smith, Arnab Mukherjee, Yuliya Kleschenko, Feng Feng, Zhi-Gang Jiang, Timothy Eitas, Kanam Malhotra, Zuzana Biesova, Adejumoke Onumajuru, Faith Finley, Anokhi Cifuentes, Guolin Zhang, Gaëlle H Martin, Yoshiko Takeuchi, Kader Thiam, Robert D Schreiber, Edward H van der Horst
VISTA, an inhibitory myeloid-T-cell checkpoint, holds promise as a target for cancer immunotherapy. However, its effective targeting has been impeded by issues such as rapid clearance and cytokine release syndrome observed with previous VISTA antibodies. Here we demonstrate that SNS-101, a newly developed pH-selective VISTA antibody, addresses these challenges. Structural and biochemical analyses confirmed the pH-selectivity and unique epitope targeted by SNS-101. These properties confer favorable pharmacokinetic and safety profiles on SNS-101...
April 4, 2024: Nature Communications
#2
JOURNAL ARTICLE
Kelly D Moynihan, Manu P Kumar, Hussein Sultan, Danielle C Pappas, Terrence Park, S Michael Chin, Paul Bessette, Ruth Y Lan, Henry C Nguyen, Nathan D Mathewson, Irene Ni, Wei Chen, Yonghee Lee, Sindy Liao-Chan, Jessie Chen, Ton N M Schumacher, Robert D Schreiber, Yik A Yeung, Ivana M Djuretic
IL-2 signals pleiotropically on diverse cell types, some of which contribute to therapeutic activity against tumors, while others drive undesired activity, such as immunosuppression or toxicity. We explored the theory that targeting of IL-2 to CD8+ T cells, which are key anti-tumor effectors, could enhance its therapeutic index. To this aim, we developed AB248, CD8 cis-targeted IL-2 that demonstrates over 500-fold preference for CD8+ T cells over NK and Treg cells, which may contribute to toxicity and immunosuppression, respectively...
April 2, 2024: Cancer Discovery
#3
Samuel Achilefu, Christopher Egbulefu, Kvar Black, Xinming Su, Partha Karmakar, LeMoyne Habimana-Griffin, Gail Sudlow, Julie Prior, Ezugo Onejeme, Alexander Zheleznyak, Baogang Xu, Yalin Xu, Alison Esser, Matthew Mixdorf, Evan Moss, Brad Manion, Nathan Reed, Matthew Gubin, Chieh-Yu Lin, Robert Schreiber, Katherine N Weilabaecher
Interactions of light-sensitive drugs and materials with Cerenkov radiation-emitting radiopharmaceuticals generate cytotoxic reactive oxygen species (ROS) to inhibit localized and disseminated cancer progression, but the cell death mechanisms underlying this radionuclide stimulated dynamic therapy (RaST) remain elusive. Using ROS-regenerative nanophotosensitizers coated with a tumor-targeting transferrin-titanocene complex (TiO2-TC-Tf) and radiolabeled 2-fluorodeoxyglucose (18FDG), we found that adherent dying cells maintained metabolic activity with increased membrane permeabilization...
March 12, 2024: Research Square
#4
EDITORIAL
David R Wunsch, Robert P Schreiber
No abstract text is available yet for this article.
March 29, 2024: Ground Water
#5
JOURNAL ARTICLE
Kristen Haggerty, Stuart Cantlay, Emily Young, Mariah K Cashbaugh, Elio F Delatore Iii, Rori Schreiber, Hayden Hess, Daniel R Komlosi, Sarah Butler, Dalton Bolon, Theresa Evangelista, Takoda Hager, Claire Kelly, Katherine Phillips, Jada Voellinger, Robert M Q Shanks, Joseph Horzempa
Utilization of fluorescent proteins is widespread for the study of microbial pathogenesis and host-pathogen interactions. Here, we discovered that linkage of the 36 N-terminal amino acids of FTL_0580 (a hypothetical protein of Francisella tularensis) to fluorescent proteins increases the fluorescence emission of bacteria that express these recombinant fusions. This N-terminal peptide will be referred to as 580N. Western blotting revealed that the linkage of 580N to Emerald Green Fluorescent Protein (EmGFP) in F...
March 14, 2024: Molecular and Cellular Probes
#6
JOURNAL ARTICLE
David Lohr, Arne Thiele, Max Stahnke, Vera M Braun, Robert Klopfleisch, Oliver Klein, Sandra Dresen, Ulf Landmesser, Anna Foryst-Ludwig, Ulrich Kintscher, Laura M Schreiber, Niklas Beyhoff
Anthracyclines are highly potent anti-cancer drugs, but their clinical use is limited by severe cardiotoxic side effects. The impact of anthracycline-induced cardiotoxicity (AIC) on left ventricular (LV) microarchitecture and diffusion properties remains unknown. This study sought to characterize AIC by cardiovascular magnetic resonance diffusion tensor imaging (DTI). Mice were treated with Doxorubicin (DOX; n = 16) for induction of AIC or saline as corresponding control (n = 15)...
March 14, 2024: Basic Research in Cardiology
#7
JOURNAL ARTICLE
Mark Ellrichmann, Berenice Schulte, Claudio C Conrad, Stephan Schoch, Johannes Bethge, Marcus Seeger, Robert Huber, Madita Goeb, Alexander Arlt, Susanna Nikolaus, Christoph Röcken, Stefan Schreiber
BACKGROUND AND AIM: Though colonoscopy plays a crucial role in assessing active ulcerative colitis (aUC), its scope is limited to the mucosal surface. Endoscopic ultrasound (EUS) coupled with contrast-enhancement (dCEUS) can precisely quantify bowel wall thickness and microvascular circulation, potentially enabling the quantitative evaluation of inflammation.We conducted a prospective, longitudinal study to assess therapy response using dCEUS in aUC patients undergoing treatment with adalimumab (ADA) or infliximab (IFX)...
March 8, 2024: Journal of Crohn's & Colitis
#8
JOURNAL ARTICLE
Robert P Gowers, Susanne Schreiber
The biophysical properties of neurons not only affect how information is processed within cells, they can also impact the dynamical states of the network. Specifically, the cellular dynamics of action-potential generation have shown relevance for setting the (de)synchronisation state of the network. The dynamics of tonically spiking neurons typically fall into one of three qualitatively distinct types that arise from distinct mathematical bifurcations of voltage dynamics at the onset of spiking. Accordingly, changes in ion channel composition or even external factors, like temperature, have been demonstrated to switch network behaviour via changes in the spike onset bifurcation and hence its associated dynamical type...
March 4, 2024: PLoS Computational Biology
#9
JOURNAL ARTICLE
Katharina Vill, Moritz Tacke, Anna König, Matthias Baumann, Manuela Baumgartner, Meike Steinbach, Guenther Bernert, Astrid Blaschek, Marcus Deschauer, Marina Flotats-Bastardas, Johannes Friese, Susanne Goldbach, Martin Gross, René Günther, Andreas Hahn, Tim Hagenacker, Erwin Hauser, Veronka Horber, Sabine Illsinger, Jessika Johannsen, Christoph Kamm, Jan C Koch, Heike Koelbel, Cornelia Koehler, Kirsten Kolzter, Hanns Lochmüller, Albert Ludolph, Alexander Mensch, Gerd Meyer Zu Hoerste, Monika Mueller, Wolfgang Mueller-Felber, Christoph Neuwirth, Susanne Petri, Kristina Probst-Schendzielorz, Manuel Pühringer, Robert Steinbach, Ulrike Schara-Schmidt, Mareike Schimmel, Bertold Schrank, Oliver Schwartz, Kurt Schlachter, Annette Schwerin-Nagel, Gudrun Schreiber, Martin Smitka, Raffi Topakian, Regina Trollmann, Matthias Tuerk, Manuela Theophil, Christian Rauscher, Mathias Vorgerd, Maggie C Walter, Markus Weiler, Claudia Weiss, Ekkehard Wilichowski, Claudia D Wurster, Gilbert Wunderlich, Daniel Zeller, Andreas Ziegler, Janbernd Kirschner, Astrid Pechmann
Newborn screening for 5qSMA offers the potential for early, ideally pre-symptomatic, therapeutic intervention. However, limited data exist on the outcomes of individuals with 4 copies of SMN2, and there is no consensus within the SMA treatment community regarding early treatment initiation in this subgroup. To provide evidence-based insights into disease progression, we performed a retrospective analysis of 268 patients with 4 copies of SMN2 from the SMArtCARE registry in Germany, Austria and Switzerland. Inclusion criteria required comprehensive baseline data and diagnosis outside of newborn screening...
February 27, 2024: Journal of Neurology
#10
JOURNAL ARTICLE
Yan Yuan, Kristin Schreiber, K Mikayla Flowers, Robert Edwards, Desiree Azizoddin, LauraEllen Ashcraft, Christina E Newhill, Valerie Hruschak
OBJECTIVES: Pain catastrophizing (PC) is a cognitive/emotional response to and in anticipation of pain, which may be maladaptive, further exacerbating pain and the difficulty in emotion regulation (ER). There is a lack of research on the interplay between PC and ER and its impact on pain. Our aim was to investigate whether ER exacerbated the pain experience through PC. MATERIALS AND METHODS: Adults with chronic pain of > 3 months' duration (n = 150) with non-cancer pain and taking opioid medication were recruited from a large medical center in Pennsylvania...
February 19, 2024: Pain Medicine
#11
JOURNAL ARTICLE
Sara M DeForge, Kyla Smith, Kris-Ann Anderson, Ashton R Baltazar, Meghan Beck, Andrea C Enzinger, James A Tulsky, Matthew Allsop, Robert R Edwards, Kristin L Schreiber, Desiree R Azizoddin
OBJECTIVE: Pain is common among people with advanced cancer. While opioids provide significant relief, incorporating psycho-behavioral treatments may improve pain outcomes. We examined patients' experiences with pain self-management and how their self-management of chronic, cancer-related pain may be complemented by behavioral mobile health (mHealth) interventions. METHODS: We conducted semi-structured qualitative interviews with patients with advanced cancer and pain...
February 2024: Psycho-oncology
#12
JOURNAL ARTICLE
René Günther, Claudia Diana Wurster, Svenja Brakemeier, Alma Osmanovic, Olivia Schreiber-Katz, Susanne Petri, Zeljko Uzelac, Miriam Hiebeler, Simone Thiele, Maggie C Walter, Markus Weiler, Tobias Kessler, Maren Freigang, Hanna Sophie Lapp, Isabell Cordts, Paul Lingor, Marcus Deschauer, Andreas Hahn, Kyriakos Martakis, Robert Steinbach, Benjamin Ilse, Annekathrin Rödiger, Julia Bellut, Julia Nentwich, Daniel Zeller, Mohamad Tareq Muhandes, Tobias Baum, Jan Christoph Koch, Bertold Schrank, Sophie Fischer, Andreas Hermann, Christoph Kamm, Steffen Naegel, Alexander Mensch, Markus Weber, Christoph Neuwirth, Helmar C Lehmann, Gilbert Wunderlich, Christian Stadler, Maike Tomforde, Annette George, Martin Groß, Astrid Pechmann, Janbernd Kirschner, Matthias Türk, Mareike Schimmel, Günther Bernert, Pascal Martin, Christian Rauscher, Gerd Meyer Zu Hörste, Petra Baum, Wolfgang Löscher, Marina Flotats-Bastardas, Cornelia Köhler, Kristina Probst-Schendzielorz, Susanne Goldbach, Ulrike Schara-Schmidt, Wolfgang Müller-Felber, Hanns Lochmüller, Otgonzul von Velsen, Christoph Kleinschnitz, Albert C Ludolph, Tim Hagenacker
BACKGROUND: Evidence for the efficacy of nusinersen in adults with 5q-associated spinal muscular atrophy (SMA) has been demonstrated up to a period of 16 months in relatively large cohorts but whereas patients reach a plateau over time is still to be demonstrated. We investigated the efficacy and safety of nusinersen in adults with SMA over 38 months, the longest time period to date in a large cohort of patients from multiple clinical sites. METHODS: Our prospective, observational study included adult patients with SMA from Germany, Switzerland, and Austria (July 2017 to May 2022)...
April 2024: The Lancet regional health. Europe
#13
JOURNAL ARTICLE
Jenna M Wilson, Angelina R Franqueiro, Robert R Edwards, Peter R Chai, Kristin L Schreiber
OBJECTIVE: We investigated the impact of favorite music on pain processing among individuals with fibromyalgia. We also examined differences in pain processing between individuals with fibromyalgia and healthy controls (HC) while listening to favorite music, and explored whether psychosocial factors contributed to these differences. METHODS: Individuals with fibromyalgia and HC completed baseline psychosocial questionnaires and then underwent quantitative sensory testing (QST) during 3 randomized music conditions (meditative music, favorite music, white noise)...
January 30, 2024: Pain Medicine
#14
JOURNAL ARTICLE
Meghan Beck, Kristin L Schreiber, Jenna M Wilson, K Mikayla Flowers, Robert R Edwards, Peter R Chai, Desiree R Azizoddin
PURPOSE: Patients with cancer may experience pain from cancer itself or its treatment. Additionally, chronic pain (CP) predating a patient's cancer diagnosis may make the etiology of pain less clear and the management of pain more complex. In this brief report, we investigated differences in biopsychosocial characteristics, pain severity, and opioid consumption, comparing groups of cancer patients with and without a history of CP who presented to the emergency department (ED) with a complaint of cancer-related pain...
January 25, 2024: Supportive Care in Cancer
#15
RANDOMIZED CONTROLLED TRIAL
Farhad Rezvani, Dirk Heider, Hans-Helmut König, Lutz Herbarth, Patrick Steinisch, Franziska Schuhmann, Hannes Böbinger, Gundula Krack, Thomas Korth, Lara Thomsen, Daniela Patricia Chase, Robert Schreiber, Mark-Dominik Alscher, Benjamin Finger, Martin Härter, Jörg Dirmaier
BACKGROUND: Supervised exercise programs are commonly used to treat intermittent claudication (IC). Home-based exercise programs have been developed to lower barriers to participation. We studied the effects of one such program (TeGeCoach) on self-reported walking ability in patients with IC. METHODS: In a pragmatic, multicenter, randomized and controlled trial (registration number NCT03496948), 1982 patients with symptomatic IC, insured by one of three German statutory health-insurance carriers, received either telephone health coaching with remote exercise monitoring (TeGeCoach; n = 994) or routine care (n = 988)...
April 19, 2024: Deutsches Ärzteblatt International
#16
RANDOMIZED CONTROLLED TRIAL
Desiree R Azizoddin, Sara M DeForge, Ashton Baltazar, Robert R Edwards, Matthew Allsop, James A Tulsky, Michael S Businelle, Kristin L Schreiber, Andrea C Enzinger
PURPOSE: We developed and piloted a mobile health app to deliver cognitive behavioral therapy for pain (pain-CBT), remote symptom monitoring, and pharmacologic support for patients with pain from advanced cancer. METHODS: Using an iterative process of patient review and feedback, we developed the STAMP + CBT app. The app delivers brief daily lessons from pain-CBT and pain psychoeducation, adapted for advanced cancer. Daily surveys assess physical symptoms, psychological symptoms, opioid utilization and relief...
January 22, 2024: Supportive Care in Cancer
#17
JOURNAL ARTICLE
Dayana Hayek, Gabriel Ziegler, Luca Kleineidam, Frederic Brosseron, Aditya Nemali, Niklas Vockert, Kishore A Ravichandran, Matthew J Betts, Oliver Peters, Luisa-Sophie Schneider, Xiao Wang, Josef Priller, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Claudia Bartels, Ayda Rostamzadeh, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, David Mengel, Matthis Synofzik, Matthias H Munk, Annika Spottke, Nina Roy, Sandra Roeske, Elizabeth Kuhn, Alfredo Ramirez, Laura Dobisch, Matthias Schmid, Moritz Berger, Steffen Wolfsgruber, Renat Yakupov, Stefan Hetzer, Peter Dechent, Michael Ewers, Klaus Scheffler, Björn H Schott, Stefanie Schreiber, Adelina Orellana, Itziar de Rojas, Marta Marquié, Mercè Boada, Oscar Sotolongo, Pablo García González, Raquel Puerta, Emrah Düzel, Frank Jessen, Michael Wagner, Augustín Ruiz, Michael T Heneka, Anne Maass
Neuroinflammation is a hallmark of Alzheimer's disease (AD) and both positive and negative associations of individual inflammation-related markers with brain structure and cognitive function have been described. We aimed to identify inflammatory signatures of CSF immune-related markers that relate to changes of brain structure and cognition across the clinical spectrum ranging from normal aging to AD. A panel of 16 inflammatory markers, Aβ42/40 and p-tau181 were measured in CSF at baseline in the DZNE DELCODE cohort (n = 295); a longitudinal observational study focusing on at-risk stages of AD...
January 12, 2024: Molecular Psychiatry
#18
JOURNAL ARTICLE
Jingui He, Jenna M Wilson, Kara G Fields, K Mikayla Flowers Zachos, Angelina R Franqueiro, Sharon C Reale, Michaela K Farber, Brian T Bateman, Robert R Edwards, James P Rathmell, Mieke Soens, Kristin L Schreiber
BACKGROUND: Understanding factors that explain why some women experience greater postoperative pain and consume more opioids after cesarean delivery (CD) is crucial to building an evidence base for personalized prevention. Comprehensive psychosocial assessment with validated questionnaires in the preoperative period can be time-consuming. A 3-item questionnaire has shown promise as a simpler tool to be integrated into clinical practice, but its brevity may limit the ability to explain heterogeneity in psychosocial pain modulators among individuals...
January 11, 2024: Anesthesiology
#19
JOURNAL ARTICLE
Jenna M Wilson, Victoria J Madden, Bethany D Pester, JiHee Yoon, Lauren N Papianou, Samantha M Meints, Claudia M Campbell, Michael T Smith, Jennifer A Haythornthwaite, Robert R Edwards, Kristin L Schreiber
BACKGROUND AND OBJECTIVES: Knee osteoarthritis is one of the primary causes of chronic pain among older adults and because of the aging population, the number of total knee arthroplasties (TKAs) performed is exponentially increasing. While pain reduction is a goal of TKA, movement-evoked pain is rarely assessed pre- and post-TKA. We characterized the distributions of change in pain, function, and situational catastrophizing in patients from presurgery to 3 months postsurgery and explored associations among these pre-post changes...
2023: Innovation in Aging
#20
JOURNAL ARTICLE
Wei Meng, Robert D Schreiber, Cheryl F Lichti
The role of aberrantly expressed proteins in tumors in driving immune-mediated control of cancer has been well documented for more than five decades. Today, we know that both aberrantly expressed normal proteins as well as mutant proteins (neoantigens) can function as tumor antigens in both humans and mice. Next-generation sequencing (NGS) and high-resolution mass spectrometry (MS) technologies have made significant advances since the early 2010s, enabling detection of rare but clinically relevant neoantigens recognized by T cells...
2023: Advances in Immunology
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