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https://www.readbyqxmd.com/read/28926340/efficacy-of-inhaled-nitric-oxide-in-neonates-with-hypoxic-respiratory-failure-and-pulmonary-hypertension-the-japanese-experience
#1
Satoshi Suzuki, Hajime Togari, Jim L Potenziano, Michael D Schreiber
OBJECTIVE: To analyze data from a registry of Japanese neonates with hypoxic respiratory failure associated with pulmonary hypertension (PH) to compare the effectiveness of inhaled nitric oxide (iNO) in neonates born <34 weeks vs. ≥34 weeks gestational age (GA). MATERIALS AND METHODS: iNO was administered according to approved Japanese product labeling. Study data were collected before iNO administration and at predefined intervals until discontinuation. RESULTS: A total of 1,114 neonates were included (n=431, <34 weeks GA; n=675, ≥34 weeks GA; n=8, missing age data)...
September 19, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28924317/comparative-evaluation-of-anchorage-reinforcement-between-orthodontic-implants-and-conventional-anchorage-in-orthodontic-management-of-bimaxillary-dentoalveolar-protrusion
#2
S S Chopra, Manish Mukherjee, Rajat Mitra, Gagan Deep Kochar, Abhijeet Kadu
BACKGROUND: Increased upper lip procumbency is commonly associated with maxillary dentoalveolar protrusion with the major goal of reducing maxillary dentoalveolar protrusion. The treatment plan usually includes extraction of the maxillary first premolars, followed by retraction of anterior teeth with maximum anchorage. Dental implants have been widely accepted as successful adjuncts for obtaining maximum anchorage in orthodontic treatment. METHODS: 50 subjects between the ages of 13 and 17 years having bimaxillary dentoalveolar protrusion were included in the study...
April 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28916840/a-novel-col1a2-c-propeptide-cleavage-site-mutation-causing-high-bone-mass-osteogenesis-imperfecta-with-a-regional-distribution-pattern
#3
T Rolvien, U Kornak, J Stürznickel, T Schinke, M Amling, S Mundlos, R Oheim
Osteogenesis imperfecta (OI) is typically characterized by low bone mass and increased bone fragility caused by heterozygous mutations in the type I procollagen genes (COL1A1/COL1A2). We report two cases of a 56-year-old woman and her 80-year-old mother who suffered from multiple vertebral and non-vertebral fractures with onset in early childhood. A full osteologic assessment including dual-energy X-ray absorptiometry (DXA), high-resolution peripheral quantitative computed tomography (HR-pQCT), and serum analyses pointed to a high bone mineral density (BMD) in the hip (DXA Z-score + 3...
September 15, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28916607/cauliflower-like-appearance-of-calcified-nodules-observed-by-coronary-angioscopy
#4
Kazuoki Dai, Kazuki Suruga, Yasuhisa Nakao, Yusuke Kobayashi, Yuki Ikegami, Hajime Takemoto, Tadanao Higaki, Kuniomi Oi, Tomoharu Kawase, Yasuharu Nakama, Kazuyoshi Suenari, Kenji Nishioka, Koyu Sakai, Masaya Otsuka, Yuji Shimatani, Yoshiko Masaoka, Nobuo Shiode
No abstract text is available yet for this article.
September 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28913398/total-femur-arthroplasty-for-revision-hip-failure-in-osteogenesis-imperfecta-limits-of-biology
#5
Pablo Sanz-Ruiz, Manuel Villanueva-Martinez, Jose Antonio Calvo-Haro, Esther Carbó-Laso, Javier Vaquero-Martín
Osteogenesis imperfecta (OI) is a rare congenital disease characterized by alterations in bone quality, with susceptibility to fractures, instability, deformities, and osteoarthrosis. Prosthetic surgery in these patients is associated with an abnormally high rate of implant failures. On the other hand, abnormal bone fragility adds to the complexity of revision surgery in such individuals-thus representing a genuine challenge for the orthopaedic surgeon. We present a case of femoral reconstruction in a patient with OI and prosthetic loosening after reconstruction secondary to femoral septic pseudoarthrosis...
September 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/28912731/long-term-athletic-development-in-youth-alpine-ski-racing-the-effect-of-physical-fitness-ski-racing-technique-anthropometrics-and-biological-maturity-status-on-injuries
#6
Lisa Müller, Carolin Hildebrandt, Erich Müller, Christian Fink, Christian Raschner
Alpine ski racing is known to be a sport with a high risk of injuries. Because most studies have focused mainly on top-level athletes and on traumatic injuries, limited research exists about injury risk factors among youth ski racers. The aim of this study was to determine the intrinsic risk factors (anthropometrics, biological maturity, physical fitness, racing technique) for injury among youth alpine ski racers. Study participants were 81 youth ski racers attending a ski boarding school (50 males, 31 females; 9-14 years)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28912593/effect-of-palm-based-tocotrienols-and-tocopherol-mixture-supplementation-on-platelet-aggregation-in-subjects-with-metabolic-syndrome-a-randomised-controlled-trial
#7
Yee-Lin Gan, Ju-Yen Fu, Oi-Ming Lai, Boon-How Chew, Kah-Hay Yuen, Kim-Tiu Teng, Kalanithi Nesaretnam, Kanga Rani Selvaduray, Puvaneswari Meganathan
Tocotrienols, the unsaturated form of vitamin E, were reported to modulate platelet aggregation and thrombotic mechanisms in pre-clinical studies. Using a Food and Drug Administration (FDA)-approved cartridge-based measurement system, a randomised, double-blind, crossover and placebo-controlled trial involving 32 metabolic syndrome adults was conducted to investigate the effect of palm-based tocotrienols and tocopherol (PTT) mixture supplementation on platelet aggregation reactivity. The participants were supplemented with 200 mg (69% tocotrienols and 31% α-tocopherol) twice daily of PTT mixture or placebo capsules for 14 days in a random order...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912573/low-magnitude-high-frequency-vibration-accelerated-the-foot-wound-healing-of-n5-streptozotocin-induced-diabetic-rats-by-enhancing-glucose-transporter-4-and-blood-microcirculation
#8
Caroline Oi-Ling Yu, Kwok-Sui Leung, Jonney Lei Jiang, Tina Bai-Yan Wang, Simon Kwoon-Ho Chow, Wing-Hoi Cheung
Delayed wound healing is a Type 2 diabetes mellitus (DM) complication caused by hyperglycemia, systemic inflammation, and decreased blood microcirculation. Skeletal muscles are also affected by hyperglycemia, resulting in reduced blood flow and glucose uptake. Low Magnitude High Frequency Vibration (LMHFV) has been proven to be beneficial to muscle contractility and blood microcirculation. We hypothesized that LMHFV could accelerate the wound healing of n5-streptozotocin (n5-STZ)-induced DM rats by enhancing muscle activity and blood microcirculation...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911256/immune-reconstitution-inflammatory-syndrome-in-patients-with-aids-and-disseminated-coccidioidomycosis-a-case-series-and-review-of-the-literature
#9
Anandit Mu, Thwe Thwe Shein, Priya Jayachandran, Simon Paul
Coccidioidomycosis causes substantial morbidity and mortality in endemic areas, and dissemination is frequent in patients with impaired cellular immunity such as AIDS. Immune reconstitution inflammatory syndrome (IRIS) is paradoxical clinical worsening after initiation of antiretroviral therapy (ART) in a patient with HIV and a simultaneous opportunistic infection (OI). Immune reconstitution inflammatory syndrome has been well described for a host of mycobacterial, viral, and fungal OIs and malignancies such as Kaposi sarcoma...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28904723/osteogenesis-imperfecta-type-iv-a-newly-identified-variant-at-position-c-560-g-t-p-gly187val-in-the-col1a2-gene
#10
Akin Usta, Dilay Karademir, Eylem Sen, Selcuk Yazici, Ertan Adali, Erkan Erdem, Meric Karacan
Osteogenesis imperfecta is a clinically heterogenous disease caused by defective collagen syntesis associated with a mutation in the COL1A1 or COL1A2 genes. In this report, we present a case of osteogenesis imperfecta (OI) type IV, seen in a female fetus with incurved femurs at 18 weeks of gestation. Molecular analysis of the newborn revealed a novel mutation at position c.560 (c.560 G > T) of the exon 12 in the COL1A2 gene; which lead to the glycine modification with valine (p.Gly187Val) at codon 187. The pregnancy follow-up was uneventful...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28902000/evaluation-of-fracture-and-osteotomy-union-in-the-setting-of-osteogenesis-imperfecta-reliability-of-the-modified-radiographic-union-score-for-tibial-fractures-rust
#11
Jeanne M Franzone, Mark S Finkelstein, Kenneth J Rogers, Richard W Kruse
BACKGROUND: Evaluation of the union of osteotomies and fractures in patients with osteogenesis imperfecta (OI) is a critical component of patient care. Studies of the OI patient population have so far used varied criteria to evaluate bony union. The radiographic union score for tibial fractures (RUST), which was subsequently revised to the modified RUST, is an objective standardized method of evaluating fracture healing. We sought to evaluate the reliability of the modified RUST in the setting of the tibias of patients with OI...
September 8, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28901398/application-of-next%C3%A2-generation-sequencing-for-molecular-diagnosis-in-a-large-family-with-osteogenesis-imperfecta-type-i
#12
Mengxia Ni, Hao Ding, Shuaimei Liu, Peiran Zhu, Qiuyue Wu, Weiwei Li, Jing Zhang, Weijun Jiang, Xinyi Xia
Increased bone fragility and low bone mass are common features of osteogenesis imperfecta (OI), which is associated with connective tissue. Its type is distinguished by clinical phenotypes and molecular genetics. Although fifteen types (I‑XV) of OI have been identified at present, the majority of patients are diagnosed as OI type I‑IV. Type I collagen is responsible for OI type I‑IV, consists of α1 (I) and α2 (I) chains and is encoded by COL1A1 and COL1A2. To identify the pathogenic gene of a large Chinese family with OI type I and explain genetic heterogeneity of the patients, next‑generation sequencing (NGS) was conducted in a female with OI type I and her affected niece and daughter to search for the mutation...
September 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28900235/neural-correlates-of-ambient-thermal-sensation-an-fmri-study
#13
Hajime Oi, Teruo Hashimoto, Takayuki Nozawa, Akitake Kanno, Natasha Kawata, Kanan Hirano, Yuki Yamamoto, Motoaki Sugiura, Ryuta Kawashima
An increasing number of biometeorological and psychological studies have demonstrated the importance and complexity of the processes involved in environmental thermal perception in humans. However, extant functional imaging data on thermal perception have yet to fully reveal the neural mechanisms underlying these processes because most studies were performed using local thermal stimulation and did not dissociate thermal sensation from comfort. Thus, for the first time, the present study employed functional magnetic resonance imaging (fMRI) and manipulated ambient temperature during brain measurement to independently explore the neural correlates of thermal sensation and comfort...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28900002/modeling-parkinson-s-disease-pathology-by-combination-of-fibril-seeds-and-%C3%AE-synuclein-overexpression-in-the-rat-brain
#14
Poonam Thakur, Ludivine S Breger, Martin Lundblad, Oi Wan Wan, Bengt Mattsson, Kelvin C Luk, Virginia M Y Lee, John Q Trojanowski, Anders Björklund
Although a causative role of α-synuclein (α-syn) is well established in Parkinson's disease pathogenesis, available animal models of synucleinopathy do not replicate the full range of cellular and behavioral changes characteristic of the human disease. This study was designed to generate a more faithful model of Parkinson's disease by injecting human α-syn fibril seeds into the rat substantia nigra (SN), in combination with adenoassociated virus (AAV)-mediated overexpression of human α-syn, at levels that, by themselves, are unable to induce acute dopamine (DA) neurodegeneration...
September 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28895777/effects-of-kinesio-tape-in-individuals-with-lateral-epicondylitis-a-deceptive-crossover-trial
#15
Ivan P H Au, Pak Che Patricia Fan, Wang Yiu Lee, Man Wai Leong, Oi Yin Tang, Winko W An, Roy T Cheung
OBJECTIVES: To determine the true and immediate effect of applying Kinesio tape (KT) on the pain intensity, pain-free grip strength, maximal grip strength, and electromyographic activity with facilitatory KT, inhibitory KT, sham KT, and untaped condition in patients with lateral epicondylitis (LE) who were ignorant about KT. DESIGN: Deceptive crossover trial. PARTICIPANTS: Thirty-three patients with unilateral chronic LE who were ignorant about KT, 30 of them were successfully deceived in this study...
September 12, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28894358/therapy-with-pamidronate-in-children-with-osteogenesis-imperfecta
#16
Otilia Marginean, Raluca Corina Tamasanu, Niculina Mang, Ioana Mozos, Giorgiana Flavia Brad
Osteogenesis imperfecta (OI) is a genetic disease characterized by excessive bone fragility with fractures consecutive to minor trauma. Considering lack of standardization of therapy with pamidronate in children, it was our aim to present our experience over a period of 10 years regarding evolution and treatment in patients diagnosed with osteoporosis and OI. Nine patients diagnosed with OI were admitted to the First Pediatric Clinic, Timisoara. They were investigated (clinical, biomarkers of bone metabolism and imaging studies), and a quality-of-life questionnaire was used to evaluate the impact of OI...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28894087/hypoxia-inducible-factor-hif-1-promotes-myeloid-derived-suppressor-cells-accumulation-through-entpd2-cd39l1-in-hepatocellular-carcinoma
#17
David Kung-Chun Chiu, Aki Pui-Wah Tse, Iris Ming-Jing Xu, Jane Di Cui, Robin Kit-Ho Lai, Lynna Lan Li, Hui-Yu Koh, Felice Ho-Ching Tsang, Larry Lai Wei, Chun-Ming Wong, Irene Oi-Lin Ng, Carmen Chak-Lui Wong
Myeloid-derived suppressor cells (MDSCs) possess immunosuppressive activities, which allow cancers to escape immune surveillance and become non-responsive to immune checkpoints blockade. Here we report hypoxia as a cause of MDSC accumulation. Using hepatocellular carcinoma (HCC) as a cancer model, we show that hypoxia, through stabilization of hypoxia-inducible factor-1 (HIF-1), induces ectoenzyme, ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2/CD39L1), in cancer cells, causing its overexpression in HCC clinical specimens...
September 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28893750/cost-effectiveness-of-planned-birth-in-a-birth-centre-compared-with-alternative-planned-places-of-birth-results-of-the-dutch-birth-centre-study
#18
Marit Hitzert, Marieke Maa Hermus, Inge Ic Boesveld, Arie Franx, Karin Km van der Pal-de Bruin, Eric Eap Steegers, EIske Me van den Akker-van Marle
OBJECTIVES: To estimate the cost-effectiveness of a planned birth in a birth centre compared with alternative planned places of birth for low-risk women. In addition, a distinction has been made between different types of locations and integration profiles of birth centres. DESIGN: Economic evaluation based on a prospective cohort study. SETTING: 21 Dutch birth centres, 46 hospital locations where midwife-led birth was possible and 110 midwifery practices where home birth was possible...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28892217/squamous-cell-carcinoma-antigen-as-a-novel-candidate-marker-for-amniotic-fluid-embolism
#19
Natsuki Koike, Hidekazu Oi, Katsuhiko Naruse, Naohiro Kanayama, Hiroshi Kobayashi
AIM: We aimed to evaluate the clinical usefulness of serum squamous cell carcinoma (SCC) antigen for the diagnosis of amniotic fluid embolism (AFE). METHODS: Sera and information of 20 patients with AFE (autopsy-proven AFE, four cases; clinical AFE, 16 cases) were obtained from the Japan Amniotic Fluid Embolism Registration Center at Hamamatsu University School of Medicine. As controls, we included 74 gestational-age-matched healthy women who gave birth to healthy newborns during the period from December 2012 to January 2014...
September 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28891585/first-principles-calculations-of-oxygen-interstitials-in-corundum-a-site-symmetry-approach
#20
Robert A Evarestov, Alexander Platonenko, Denis Gryaznov, Yuri F Zhukovskii, Eugene A Kotomin
Using site symmetry analysis, four possible positions of interstitial oxygen atoms in the α-Al2O3 hexagonal structure have been identified and studied. First principles hybrid functional calculations of the relevant atomic and electronic structures for interstitial Oi atom insertion in these positions reveal differences in energies of ∼1.5 eV. This approach allows us to get the lowest energy configuration, avoiding time-consuming calculations. It is shown that the triplet oxygen atom is barrierless displaced towards the nearest regular oxygen ion, forming a singlet dumbbell (split interstitial) configuration with an energy gain of ∼2...
September 11, 2017: Physical Chemistry Chemical Physics: PCCP
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