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https://www.readbyqxmd.com/read/29786476/orthopedic-injured-versus-uninjured-comparison-groups-for-neuroimaging-research-in-mild-traumatic-brain-injury
#1
Elisabeth A Wilde, Ashley L Ware, Xiaoqi Li, Trevor C Wu, Stephen R McCauley, Amanda Barnes, Mary Newsome, Brian Biekman, Jill V Hunter, Zili Chu, Harvey Levin
To address controversy surrounding the most appropriate comparison group for mild traumatic brain injury (mTBI) research, mTBI patients aged 12-30 years were compared to an extracranial orthopedic injury (OI) patient group and an uninjured, typically-developing (TD) participant group with comparable demographic backgrounds. Injured participants underwent subacute (within 96 hours) and late (3 months) diffusion tensor imaging (DTI); TD controls underwent DTI once. Group differences in fractional anisotropy (FA) and mean diffusivity (MD) of commonly studied white matter tracts were assessed...
May 22, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29779185/predictive-role-of-measurement-of-pelvic-floor-muscle-thickness-with-static-mri-in-stress-and-mixed-urinary-incontinence
#2
Levent Yaşar, Serpil Ortakuz Telci, Keziban Doğan, Eyüp Kaya, Murat Ekin
INTRODUCTION AND HYPOTHESIS: To investigate the role of measuring the thickness of pelvic floor muscles with static MRI in the physiopathology of urinary incontinence in women with stress and mixed types of urinary incontinence diagnosed with urodynamic studies. METHODS: A retrospective clinical study was designed in collaboration with the radiology department. We recruited only patients who had undergone static pelvic MRI to determine the etiology of pelvic pain and exclude gynecologic disorders...
May 19, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29775319/operando-evidence-for-a-universal-oxygen-evolution-mechanism-on-thermal-and-electrochemical-iridium-oxides
#3
Viktoriia A Saveleva, Li Wang, Detre Teschner, Travis E Jones, Aldo S Gago, K Andreas Friedrich, Spyridon Zafeiratos, Robert Schloegl, Elena R Savinova
Progress in the development of the proton exchange membrane (PEM) water electrolysis technology requires decreasing the anode overpotential, where the sluggish multistep oxygen evolution reaction (OER) occurs. This calls for the understanding of the nature of the active OER sites and reaction intermediates, which are still being debated. In this work, we apply synchrotron radiation - based near ambient pressure X-ray photoelectron and absorption spectroscopies under operando conditions in order to unveil the nature of the reaction intermediates and shed light on the OER mechanism on electrocatalysts most widely used in PEM electrolyzers - electrochemical and thermal iridium oxides...
May 18, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29766672/ribcage-deformity-and-the-altered-breathing-pattern-in-children-with-osteogenesis-imperfecta
#4
Antonella LoMauro, Paolo Fraschini, Simona Pochintesta, Marianna Romei, Maria G D'Angelo, Andrea Aliverti
AIM: Osteogenesis Imperfecta (OI) is a genetic disease characterized by bones fragility and progressive deformity. Life expectancy is reduced in the non-lethal most severe type III form before the age of 10 years. The main cause of death in OI is respiratory insufficiency resulting from impaired thoracic function worsened by ribcage deformity and scoliosis. METHODS: We used opto-electronic plethysmography to study chest geometry, the ventilatory, and the thoraco-abdominal pattern at rest in supine position in children younger than 10 years...
May 15, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29764212/the-clinical-application-of-single-sperm-based-snp-haplotyping-for-pgd-of-osteogenesis-imperfecta
#5
Linjun Chen, Zhenyu Diao, Zhipeng Xu, Jianjun Zhou, Guijun Yan, Haixiang Sun
Osteogenesis imperfecta (OI) is a genetically heterogeneous disorder, presenting either autosomal dominant, autosomal recessive or X-linked inheritance patterns. The majority of OI cases are autosomal dominant and are caused by heterozygous mutations in either the COL1A1 or COL1A2 gene. In these dominant disorders, allele dropout (ADO) can lead to misdiagnosis in preimplantation genetic diagnosis (PGD). Polymorphic markers linked to the mutated genes have been used to establish haplotypes for identifying ADO and ensuring the accuracy of PGD...
May 15, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29758270/collagen-gly-missense-mutations-effect-of-residue-identity-on-collagen-structure-and-integrin-binding
#6
Yimin Qiu, Arya Mekkat, Hongtao Yu, Sezin Yigit, Samir Hamaia, Richard W Farndale, David L Kaplan, Yu-Shan Lin, Barbara Brodsky
Gly missense mutations in type I collagen, which replace a conserved Gly in the repeating (Gly-Xaa-Yaa)n sequence with a larger residue, are known to cause Osteogenesis Imperfecta (OI). The clinical consequences of such mutations range from mild to lethal, with more serious clinical severity associated with larger Gly replacement residues. Here, we investigate the influence of the identity of the residue replacing Gly within and adjacent to the integrin binding 502 GFPGER507 sequence on triple-helix structure, stability and integrin binding using a recombinant bacterial collagen system...
May 11, 2018: Journal of Structural Biology
https://www.readbyqxmd.com/read/29756694/effects-of-inhalation-and-intravenous-anaesthesia-on-intraoperative-cardiopulmonary-function-and-postoperative-complications-in-patients-undergoing-thoracic-surgery-a-systematic-review-and-meta-analysis
#7
Qian-Yun Pang, Ran An, Hong-Liang Liu
INTRODUCTION: There is a high incidence of postoperative cardiopulmonary complications after thoracic surgery with one lung ventilation (OLV), the effect of general anaesthetics on intraoperative cardiopulmonary function and postoperative complications is still unclear. EVIDENCE ACQUISITION: We searched the Embase, Pubmed, Cochrane Library, Springer, Wiley, CNKI, VIP and Wanfang databases for randomized controlled trials (RCTs) in which inhalation anaesthesia and intravenous anaesthesia were compared; intraoperative cardiopulmonary function and postoperative complications were assessed in patients undergoing thoracic surgery with intraoperative one-lung ventilation (OLV)...
May 11, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29729572/the-effects-of-organophosphorus-insecticides-and-heavy-metals-on-dna-damage-and-programmed-cell-death-in-two-plant-models
#8
Josefina Cortés-Eslava, Sandra Gómez-Arroyo, Maria C Risueño, Pilar S Testillano
The ubiquity of pollutants, such as agrochemicals and heavy metals, constitute a serious risk to human health. To evaluate the induction of DNA damage and programmed cell death (PCD), root cells of Allium cepa and Vicia faba were treated with two organophosphate insecticides (OI), fenthion and malathion, and with two heavy metal (HM) salts, nickel nitrate and potassium dichromate. An alkaline variant of the comet assay was performed to identify DNA breaks; the results showed comets in a dose-dependent manner, while higher concentrations induced clouds following exposure to OIs and HMs...
May 2, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29728596/microrna-143-modulates-the-expression-of-natriuretic-peptide-receptor-3-in-cardiac-cells
#9
Juan Wang, Kai Sing Tong, Lee Lee Wong, Oi-Wah Liew, Divya Raghuram, Arthur Mark Richards, Yei-Tsung Chen
Natriuretic Peptide Receptor 3 (NPR3), the clearance receptor for extracellular bio-active natriuretic peptides (NPs), plays important roles in the homeostasis of body fluid volume and vascular tone. Using luciferase reporter and antagomir-based silencing assays, we demonstrated that the expression of NPR3 could be modulated by microRNA-143 (miR-143-3p), a microRNA species with up-regulated circulating concentrations in clinical heart failure. The regulatory effect of miR-143 on NPR3 expression was further evidenced by the reciprocal relationship between miR-143 and NPR3 levels observed in hypoxia-treated human cardiac cells and in left ventricular tissue from rats undergoing experimental myocardial infarction...
May 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29722291/effect-of-nickel-diffusion-and-oxygen-behavior-on-heterojunction-schottky-diodes-of-au-nio-zno-with-a-nio-interlayer-prepared-by-radio-frequency-magnetron-sputtering
#10
Jun-Dar Hwang, Hsin-Yu Chen, Yu-Hung Chen, Ting-Hsiu Ho
The rectifying characteristic of Au/ZnO Schottky diodes (SDs) was remarkably improved by introducing a NiO layer in-between the Au and ZnO layers. Compared with the Au/ZnO SDs, the introduction of the NiO layer significantly enhanced the rectification ratio from 1.38 to 1,300, and reduced the ideality factor from 5.78 to 2.14. The NiO and ZnO layers were deposited on an indium-tin-oxide/glass substrate by radio-frequency magnetron sputtering. Secondary ion mass spectroscopy showed that Ni atoms diffused from NiO to ZnO, leading to a graded distribution of Ni in ZnO...
May 3, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29717626/the-moderating-effect-of-ankk1-on-the-association-of-family-environment-with-longitudinal-executive-function-following-traumatic-brain-injury-in-early-childhood-a-preliminary-study
#11
Julia Smith-Paine, Shari L Wade, Amery Treble-Barna, Nanhua Zhang, Huaiyu Zang, Lisa J Martin, Keith Owen Yeates, H Gerry Taylor, Brad G Kurowski
This study examined whether the ankyrin repeat and kinase domain containing 1 gene (ANKK1) C/T single-nucleotide polymorphism (SNP) rs1800497 moderated the association of family environment with long-term executive function (EF) following traumatic injury in early childhood. Caregivers of children with traumatic brain injury (TBI) and children with orthopedic injury (OI) completed the Behavior Rating Inventory of Executive Function (BRIEF) at post injury visits. DNA was collected to identify the rs1800497 genotype in the ANKK1 gene...
May 2, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29714432/extracorporeal-membrane-oxygenation-support-in-neonates-a-single-center-experience-in-turkey
#12
Emel Okulu, F. Begüm Atasay, Gaffari Tunç, Hasan Akduman, Ömer Erdeve, Saadet Arsan, Zeynep Eyileten, Tayfun Uçar, H. Ercan Tutar
Background/aim: Extracorporeal membrane oxygenation (ECMO) is a form of life support for patients with respiratory failure, cardiac failure, or both. The aim of this study was to evaluate neonates supported with ECMO and report our experience as a Turkish neonatal intensive care unit. Materials and methods: We retrospectively reviewed 11 newborn infants treated with ECMO at Ankara University for respiratory and cardiac failure. We reported the demographic, diagnostic, laboratory, and clinical data of the patients...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29707935/do-serum-vitamin-d-levels-have-any-effect-on-intrauterine-insemination-success
#13
Nafiye Yilmaz, Ebru Ersoy, Aytekin Tokmak, Ayla Sargin, A Seval Ozgu-Erdinc, Salim Erkaya, Halil Ibrahim Yakut
Background: Recent studies have shown that vitamin D has an essential role in the reproductive system. In this study, we aimed to investigate the effect of vitamin D levels in patients undergoing ovulation induction (OI), and subsequent intrauterine insemination (IUI) procedure. MATERIALS AND METHODS: One hundred and four infertile and one hundred and three fertile women were recruited in this cross-sectional study which was conducted in a tertiary level maternity hospital...
July 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29700585/location-of-the-femoral-tunnel-aperture-during-single-bundle-posterior-cruciate-ligament-reconstruction-outside-in-versus-inside-out-techniques
#14
Jun-Ho Kim, Hoon-Young Kim, Dae-Hee Lee
PURPOSE: Placement of the femoral tunnel is critical to graft function after posterior cruciate ligament (PCL) reconstruction. To date, however, the location of the femoral tunnel aperture has not been compared by in vivo 3-dimensional computed tomography (3D-CT) during PCL reconstruction with the outside-in (OI) and inside-out (IO) techniques. This study used 3D-CT analysis to compare the location of the femoral tunnel aperture in patients who underwent PCL reconstruction with the OI and IO techniques...
April 26, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29695564/diurnal-variation-of-melatonin-concentration-in-the-cerebrospinal-fluid-of-unanesthetized-microminipig
#15
Masaharu Abe, Hiroaki Kawaguchi, Naoki Miura, Kohei Akioka, Miharu Ushikai, Sayumi Oi, Airo Yukawa, Tetsuya Yoshikawa, Hiroyuki Izumi, Masahisa Horiuchi
BACKGROUND/AIM: The aim of this study was to develop a method for sequentially collecting cerebrospinal fluid (CSF) from an unanesthetized microminipig, which shares many physiological and anatomical similarities with humans, such as diurnality, and investigate the diurnal variation of melatonin concentration in the CSF. MATERIALS AND METHODS: A catheter was placed percutaneously into the subarachnoid space of an anesthetized animal, and the tip of the catheter was placed into the cisterna magna under X-ray...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29682884/durable-engraftment-of-genetically-modified-fviii-secreting-autologous-bone-marrow-stromal-cells-in-the-intramedullary-microenvironment
#16
Sze Sing Lee, Jaichandran Sivalingam, Ajit J Nirmal, Wai Har Ng, Irene Kee, In Chin Song, Chin Yong Kiong, Kristoffer A Gales, Frederic Chua, Edgar M Pena, Bryan E Ogden, Oi Lian Kon
Genetically modified FVIII-expressing autologous bone marrow-derived mesenchymal stromal cells (BMSCs) could cure haemophilia A. However, culture-expanded BMSCs engraft poorly in extramedullary sites. Here, we compared the intramedullary cavity, skeletal muscle, subcutaneous tissue and systemic circulation as tissue microenvironments that could support durable engraftment of FVIII-secreting BMSC in vivo. A zinc finger nuclease integrated human FVIII transgene into PPP1R12C (intron 1) of culture-expanded primary canine BMSCs...
April 23, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29669177/mutations-that-alter-the-carboxy-terminal-propeptide-cleavage-site-of-the-chains-of-type-i-procollagen-are-associated-with-a-unique-osteogenesis-imperfecta-phenotype
#17
Tim Cundy, Michael Dray, John Delahunt, Jannie Dahl Hald, Bente Langdahl, Chumei Li, Marta Szybowska, Shehla Mohammed, Emma L Duncan, Aideen M McInerney-Leo, Patricia G Wheeler, Paul Roschger, Klaus Klaushofer, Jyoti Rai, MaryAnn Weis, David Eyre, Ulrike Schwarze, Peter H Byers
Osteogenesis imperfecta (OI) is a genetic bone disorder characterized by fractures, low bone mass, and skeletal fragility. It most commonly arises from dominantly inherited mutations in the genes COL1A1 and COL1A2 that encode the chains of type I collagen. A number of recent reports have suggested that mutations affecting the carboxyl-terminal propeptide cleavage site in the products of either COL1A1 or COL1A2 give rise to a form of OI characterized by unusually dense bones. We have assembled clinical, biochemical, and molecular data from 29 individuals from 8 families with 7 different mutations affecting the C-propeptide cleavage site...
April 18, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29668620/olfactory-assessment-in-the-chinese-pediatric-population
#18
Guowei Chen, Hongguang Pan, Lan Li, Jumei Wang, Delun Zhang, Zebin Wu
Young children with olfactory disturbance are sometimes encountered in ENT clinics. We investigated the clinical applicability of olfactory testing to the pediatric population in China.One hundred and ninety-three healthy children aged 6 to 17 years were enrolled. All participants were asked for demographic information (age, sex, body mass index [BMI], and rating of olfactory function) in a structured questionnaire and underwent olfactory testing including T&T Olfactometer (T&T), odor discrimination (OD), and odor identification (OI) tests of Sniffin' Sticks...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29665967/structural-and-functional-changes-in-the-heart-of-adult-patients-with-osteogenesis-imperfecta-case-control-study
#19
Verónica Hernández Jiménez, Jesús Saavedra Falero, María Teresa Alberca Vela, Rebeca Mata Caballero, José Antonio Rosado Sierra, Isabel Pavón de Paz
INTRODUCTION AND OBJECTIVES: Osteogenesis imperfecta (OI) is a connective tissue disease characterised by an anomalous synthesis of type i collagen. Little is known about the cardiovascular affectation suffered by these patients. The most frequently described are valvular dysfunction and dilatation of the aorta. We wanted to analyse the structural and functional changes of the heart in adult patients with OI. METHODS: We prospectively studied 82 patients with OI and compared them with 60 healthy subjects matched for age and sex...
April 14, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29665086/severely-impaired-bone-material-quality-in-chihuahua-zebrafish-resembles-classical-dominant-human-osteogenesis-imperfecta
#20
Imke A K Fiedler, Felix N Schmidt, Eva M Wölfel, Christine Plumeyer, Petar Milovanovic, Roberta Gioia, Francesca Tonelli, Hrishikesh A Bale, Katharina Jähn, Roberta Besio, Antonella Forlino, Björn Busse
Excessive skeletal deformations and brittle fractures in the vast majority of patients suffering from osteogenesis imperfecta (OI) are a result of substantially reduced bone quality. Since the mechanical competence of bone is dependent on the tissue characteristics at small length scales, it is of crucial importance to assess how osteogenesis imperfecta manifests at the micro- and nanoscale of bone. In this context, the Chihuahua (Chi/ +) zebrafish, carrying a heterozygous glycine substitution in the α1 chain of collagen type I, has recently been proposed as suitable animal model of classical dominant OI, showing skeletal deformities, altered mineralization patterns and a smaller body size...
April 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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