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https://www.readbyqxmd.com/read/28101045/express-mini-shunt-as-a-treatment-alternative-for-medically-uncontrolled-steroid-induced-glaucoma-in-a-pediatric-patient
#1
Bonnie Nga Kwan Choy, Mandy Oi Man Wong, Jonathan Cheuk Hung Chan, Connie Hong Yee Lai, Jimmy Shiu Ming Lai
This case report illustrates the use of ExPRESS mini-shunt in a pediatric glaucoma patient. We describe the management of steroid-induced glaucoma with ExPRESS mini-shunt in a 9-year-old boy with allergic keratoconjunctivitis. The intraocular pressure of both of his eyes was uncontrolled with medical and laser treatment. Both eyes were treated with ExPRESS mini-shunt and mitomycin-C. Transient overfiltration with postoperative hypotony occurred in both eyes and resolved after 2 weeks. One year postoperatively, intraocular pressure was maintained below 21 mm Hg without medication in 1 eye...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28096453/programmable-formation-of-catalytic-rna-triangles-and-squares-by-assembling-modular-rna-enzymes
#2
Hiroki Oi, Daisuke Fujita, Yuki Suzuki, Hiroshi Sugiyama, Masayuki Endo, Shigeyoshi Matsumura, Yoshiya Ikawa
RNA is a biopolymer that is attractive for constructing nanoscale objects with complex structures. Three-dimensional (3D) structures of naturally occurring RNAs often have modular architectures. The 3D structure of a group I (GI) ribozyme from Tetrahymena has a typical modular architecture, which can be separated into two structural modules (ΔP5 and P5abc). The fully active ribozyme can be reconstructed by assembling the two separately prepared modules through highly specific and strong assembly between ΔP5 ribozyme and P5abc RNA...
January 17, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28093069/assessing-the-progression-of-chronic-periodontitis-using-subgingival-pathogen-levels-a-24-month-prospective-multicenter-cohort-study
#3
E Kakuta, Y Nomura, T Morozumi, T Nakagawa, T Nakamura, K Noguchi, A Yoshimura, Y Hara, O Fujise, F Nishimura, T Kono, M Umeda, M Fukuda, T Noguchi, N Yoshinari, C Fukaya, S Sekino, Y Numabe, N Sugano, K Ito, H Kobayashi, Y Izumi, H Takai, Y Ogata, S Takano, M Minabe, A Makino-Oi, A Saito, Y Abe, S Sato, F Suzuki, K Takahashi, T Sugaya, M Kawanami, N Hanada, S Takashiba, H Yoshie
BACKGROUND: The diagnosis of the progression of periodontitis presently depends on the use of clinical symptoms (such as attachment loss) and radiographic imaging. The aim of the multicenter study described here was to evaluate the diagnostic use of the bacterial content of subgingival plaque recovered from the deepest pockets in assessing disease progression in chronic periodontitis patients. METHODS: This study consisted of a 24-month investigation of a total of 163 patients with chronic periodontitis who received trimonthly follow-up care...
January 16, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28089253/progressive-bilateral-vertebral-artery-dissection-in-a-case-of-osteogenesis-imperfecta
#4
Yuji Kato, Harumitsu Nagoya, Tetsuya Abe, Takeshi Hayashi, Masanori Yasuda, Akira Uchino, Norio Tanahashi, Masaki Takao
A 32-year-old woman with osteogenesis imperfecta (OI) was admitted to the hospital because of a right-sided occipital headache and facial paresthesia. She was diagnosed with lateral medullary syndrome due to right vertebral artery (VA) dissection. She was treated conservatively without antithrombotic therapy. She developed subarachnoid hemorrhage because of contralateral VA dissection 18 days later. This clinical course may reflect the underlying weakness of the vessel wall in OI. In patients with OI, occlusion of a unilateral VA could cause dissection and subsequent rupture of the contralateral VA...
January 11, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28076852/mir-874-3p-is-down-regulated-in-hepatocellular-carcinoma-and-negatively-regulates-pin1-expression
#5
Ka-Wai Leong, Chi-Wai Cheng, Chun-Ming Wong, Irene Oi-Lin Ng, Yok-Lam Kwong, Eric Tse
PIN1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that regulates multiple signaling pathways to control cell fate and is found to be over-expressed in cancers, including hepatocellular carcinoma (HCC). However, the regulation of PIN1 in HCC remains poorly defined. Micro-RNAs (miRNAs) have been reported to play a pivotal role in oncogenesis by targeting the 3'-untranslated region (UTR) of mRNAs encoded by oncogenes and tumour suppressor genes, thereby suppressing the levels of both oncoproteins and tumour suppressors...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28075155/a-qualitative-study-exploring-community-yoga-practice-in-adults-with-rheumatoid-arthritis
#6
Heather M Greysen, S Ryan Greysen, Kathryn A Lee, Oi Saeng Hong, Patricia Katz, Heather Leutwyler
OBJECTIVE: Yoga may improve physical function and reduce disease symptoms in adults with rheumatoid arthritis (RA). However, little is known about how patients with RA are practicing yoga in the community. The objective of this qualitative study was to explore community yoga practice characteristics and thoughts about yoga practice for adults with RA. DESIGN: Participants completed a semi-structured telephone interview with open-ended questions. Thematic analysis was used to analyze interview transcripts...
January 11, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28071810/deer-leather-analysis-of-the-microstructure-affecting-pebble
#7
Hannah C Wells, Katie Sizeland, Sue M Cooper, Nigel Kirby, Adrian Hawley, Stephen Mudie, Richard G Haverkamp
BACKGROUND: Deer leather has a characteristic pattern, referred to as "pebble", that is accorded such importance that a lack of it renders a leather defective. Synchrotron-based small angle X-ray scattering (SAXS), ultrasonic imaging, scanning electron microscopy, and tear tests are used to investigate the structural characteristics of well pebbled and poorly pebbled cervine leathers. RESULTS: Poorly pebbled leather has a less open structure in the upper grain region than well pebbled leather...
January 10, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28068493/bmp1-and-tll1-are-required-for-maintaining-periodontal-homeostasis
#8
J Wang, D Massoudi, Y Ren, A M Muir, S E Harris, D S Greenspan, J Q Feng
Mutations in bone morphogenetic protein 1 (BMP1) in humans or deletion of BMP1 and related protease tolloid like 1 (TLL1) in mice lead to osteogenesis imperfecta (OI). Here, we show progressive periodontal defects in mice in which both BMP1 and TLL1 have been conditionally ablated, including malformed periodontal ligament (PDL) (recently shown to play key roles in normal alveolar bone formation), significant loss in alveolar bone mass ( P < 0.01), and a sharp reduction in cellular cementum. Molecular mechanism studies revealed a dramatic increase in the uncleaved precursor of type I collagen (procollagen I) and a reduction in dentin matrix protein 1 (DMP1), which is partially responsible for defects in extracellular matrix (ECM) formation and mineralization...
January 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28066531/radiographic-assessment-of-extremity-osseointegration-for-the-amputee
#9
Munjed Al Muderis, Belinda A Bosley, Anthony V Florschutz, Paul A Lunseth, Tyler D Klenow, M Jason Highsmith, Jason T Kahle
Osseointegration (OI) is a bone-anchoring procedure that allows the direct skeletal attachment of a prosthesis through the use of an implant. Transcutaneous OI implants are similar to subcutaneous intramedullary joint implants with some exceptions. Particularly, OI implants are inserted at the distal aspect of the femur, while intramedullary implants are inserted at the proximal aspect of the femur. In this report, an additional adaptation of the radiographic zonal analysis used for intramedullary implants, known as Gruen zones, is introduced to include OI implants of extremity prosthetics...
September 2016: Technology and Innovation
https://www.readbyqxmd.com/read/28065846/the-association-of-heart-failure-related-micrornas-with-neurohormonal-signaling
#10
Yei-Tsung Chen, Juan Wang, Kai Sing Tong, Lee Lee Wong, Oi Wah Liew, Arthur Mark Richards
Heart failure (HF) is a widely prevalent syndrome imposing a significant burden of morbidity and mortality world-wide. Differential circulating microRNA profiles observed in HF cohorts suggest the diagnostic utility of microRNAs as biomarkers. Given their function in fine tuning gene expression, alternations in microRNA landscape could reflecting the underlying mechanisms of disease and present potential therapeutic targets. Using multiple computational target predicting algorithms together with the luciferase-based reporting platform, the interactions between HF-related microRNAs and the 3' untranslated regions (3'UTRs) of neurohormone associated genes were examined and compared...
January 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28058531/developmental-charts-for-children-with-osteogenesis-imperfecta-type-i-body-height-body-weight-and-bmi
#11
Krzysztof Graff, Malgorzata Syczewska
: Osteogenesis imperfecta (OI) is a rare genetic disorder of type I collagen. Type I is the most common, which is called a non-deforming type of OI, as in this condition, there are no major bone deformities. This type is characterised by blue sclera and vertebral fractures, leading to mild scoliosis. The body height of these patients is regarded as normal, or only slightly reduced, but there are no data proving this in the literature. The aim of this study is the preparation of the developmental charts of children with OI type I...
January 5, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28056935/community-pharmacists-perceptions-about-pharmaceutical-service-of-over-the-counter-traditional-chinese-medicine-a-survey-study-in-harbin-of-china
#12
Menghuan Song, Carolina Oi Lam Ung, Vivian Wing-Yan Lee, Yuanjia Hu, Jing Zhao, Peng Li, Hao Hu
BACKGROUND: This study aims to investigate community pharmacist's perception on the provision of over-the-counter (OTC) traditional Chinese medicine (TCM) pharmaceutical services; focusing on the areas of their attitude, general practice, perceived barriers and suggested improvements. METHODS: Questionnaire survey targeting community pharmacists in Harbin of China was applied in this study. Questionnaires were distributed and collected at community pharmacies. Data was analyzed by combining descriptive analysis and Chi-test...
January 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28056166/nitric-oxide-for-respiratory-failure-in-infants-born-at-or-near-term
#13
REVIEW
Keith J Barrington, Neil Finer, Thomas Pennaforte, Gabriel Altit
BACKGROUND: Nitric oxide (NO) is a major endogenous regulator of vascular tone. Inhaled nitric oxide (iNO) gas has been investigated as treatment for persistent pulmonary hypertension of the newborn. OBJECTIVES: To determine whether treatment of hypoxaemic term and near-term newborn infants with iNO improves oxygenation and reduces rate of death and use of extracorporeal membrane oxygenation (ECMO), or affects long-term neurodevelopmental outcomes. SEARCH METHODS: We used the standard search strategy of the Cochrane Neonatal Review Group to search the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 1), MEDLINE via PubMed (1966 to January 2016), Embase (1980 to January 2016) and the Cumulative Index to Nursing and Allied Health Literature (CINAHL; 1982 to January 2016)...
January 5, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28049291/unique-triphenylphosphonium-derivatives-for-enhanced-mitochondrial-uptake-and-photodynamic-therapy
#14
Zhang Hu, Ying Sim, Oi Lian Kon, Wai Har Ng, António J M Ribeiro, Maria J Ramos, Pedro A Fernandes, Rakesh Ganguly, Bengang Xing, Felipe García, Edwin K L Yeow
In this study, unique methyl-functionalized derivatives (T*PP(+)) of the drug carrier triphenylphosphonium (TPP(+)) that exhibit significant enhancement of the accumulation of both the cation and its conjugated cargo in cell mitochondria are designed. We show that the presence of methyl group(s) at key positions within the phenyl ring results in an increase in the hydrophobicity and solvent accessible surface area of T*PP(+). In particular, when the para position of the phenyl ring in T*PP(+) is functionalized with a methyl group, the cation is most exposed to the surrounding environment, leading to a large decrease in water entropy and an increase in the level of van der Waals interaction with and partition into a nonpolar solvent...
January 18, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28048853/su-f-p-14-oxygen-inhalation-should-be-the-conventional-approach-in-the-treatment-of-thoracic-and-abdominal-cancer-by-radiotherapy-with-active-breathing-control-abc
#15
G Gong, Y Guo, Y Yin
PURPOSE: To investigate the feasibility and potential benefit of oxygen inhalation (OI) during radiotherapy applying an active breathing control (ABC) device, by analyzing the blood oxygen saturation (SpO2) and the instantaneous heart rate (IHR) variation in breath holding with OI and oxygen non-inhalation (ONI). METHODS: The 27 healthy volunteers (16 males, 11 females) who were involved in this trial were all required to hold their breath for 10 times, non-inhaling and inhaling oxygen successively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046874/su-f-p-46-comparative-study-between-two-normalization-prescriptions-for-accelerated-partial-breast-irradiation-a-dosimetric-study
#16
P Agarwal, D Sharma, A Gandhi, A Binjola, V Subramani, S Chander
PURPOSE: To compare the Accelerated Partial Breast Irradiation (APBI) plan with the normalized basal dose points and 5mm box prescription. METHODS: Five patients of APBI were planned twice in Oncentra Master planning TPS (Version 4.3) using TG-43 algorithm. The number of catheters for all the patients was 10 to 16 and implant plane 2 to 3. For planning all catheters were reconstructed. Source loading was done as per HR-CTV contoured. The HR-CTV volume range was from 75cc to 182cc...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045697/findings-of-optical-frequency-domain-imaging-and-coronary-angioscopy-in-a-lesion-with-spontaneous-recanalization-identified-by-serial-coronary-angiography
#17
Kazuoki Dai, Yasuhisa Nakao, Yusuke Kobayashi, Yuki Ikegami, Arinori Takeuchi, Ayako Harima, Tadanao Higaki, Kuniomi Oi, Tomoharu Kawase, Yasuharu Nakama, Kazuyoshi Suenari, Kenji Nishioka, Koyu Sakai, Masaya Otsuka, Yuji Shimatani, Yoshiko Masaoka, Nobuo Shiode, Ichiro Inoue, Masaharu Ishihara
No abstract text is available yet for this article.
December 29, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/28039314/olfaction-and-risk-of-dementia-in-a-biracial-cohort-of-older-adults
#18
Kristine Yaffe, Daniel Freimer, Honglei Chen, Keiko Asao, Andrea Rosso, Susan Rubin, Greg Tranah, Steve Cummings, Eleanor Simonsick
OBJECTIVE: Prior studies indicate that olfactory function may be an early marker for cognitive impairment, but the body of evidence has been largely restricted to white populations. METHODS: We studied 2,428 community-dwelling black and white older adults (baseline age 70-79 years) without dementia enrolled in the Health, Aging, and Body Composition (Health ABC) study. Olfaction was measured as odor identification (OI) with the 12-item Cross Cultural Smell Identification Test in year 3...
December 30, 2016: Neurology
https://www.readbyqxmd.com/read/28034594/awareness-of-tick-borne-disease-and-compliance-with-using-tick-preventive-products-of-dog-owners-in-hong-kong
#19
Maureen V Boost, Choi-Yin Tung, Claudia Hoi-Ki Ip, July Fung-Oi Man, Toni Wing-Tung Hui, Candy Fung-Yee Leung, Maggie Yuen-Wa Mak, Queeny Yuen, Margaret M O'Donoghue
Tick-borne disease in dogs is common in South-east Asia and includes babesiosis and ehrlichiosis. These diseases can be largely prevented by compliant use of tick preventive products. This study investigated knowledge of ticks and tick-borne disease and use of tick preventive agents by a large sample of dog owners in Hong Kong. A total of 492 valid questionnaires were completed by owners attending veterinary practices, approached by researchers at common dog-walking areas, or targeted via local social media sites for pet owners...
December 21, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28031688/premature-atherosclerosis-and-drug-eluting-stent-restenosis-in-an-adult-with-osteogenesis-imperfecta
#20
Mutlu Gungor, Mustafa Aparci, Ali C Özer
Mild form of osteogenesis imperfecta (OI) may have a normal life span. However, cardiovascular complications including aortic and valvular heart disease, and coronary artery disease may complicate the life period. We presented a patient with mild form of OI and premature coronary atherosclerosis. He had been performed primary percutaneous angioplasty and drug eluting stent implantation to left anterior descending coronary artery osteal lesion. Then he presented with unstable angina pectoris due to the diffuse in-stent restenosis and a highly critical lesion adjacent to previously stented segment...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
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