Sze Min Lek, Ke Li, Qiu Xuan Tan, Nicholas B Shannon, Wai Har Ng, Josephine Hendrikson, Joey W S Tan, Hui Jun Lim, Yudong Chen, Kelvin K N Koh, Thakshayeni Skanthakumar, Xue Lin Kwang, Fui Teen Chong, Hui Sun Leong, Gerald Tay, Natascha Ekawati Putri, Tony Kiat Hon Lim, Jacqueline S G Hwang, Mei Kim Ang, Daniel S W Tan, Ngian Chye Tan, Hiang Khoon Tan, Oi Lian Kon, Khee Chee Soo, N Gopalakrishna Iyer, Chin-Ann J Ong
OBJECTIVES: We have previously identified and validated a panel of molecular prognostic markers (ATP13A3, SSR3, and ANO1) for Head and Neck Squamous Cell Carcinoma (HNSCC). The aim of this study was to investigate the consequence of ATP13A3 dysregulation on signaling pathways, to aid in formulating a therapeutic strategy targeting ATP13A3-overexpressing HNSCC. MATERIALS AND METHODS: Gene Set Enrichment Analysis (GSEA) was performed on HNSCC microarray expression data (Internal local dataset [n = 92], TCGA [n = 232], EMBL [n = 81]) to identify pathways associated with high expression of ATP13A3...
October 19, 2020: Oral Oncology