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Long term adverse effects to opiods

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https://www.readbyqxmd.com/read/26839023/efficacy-of-methylnaltrexone-for-the-treatment-of-opiod-induced-constipation-a-meta-analysis-and-systematic-review
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Neel Mehta, Kelli O'Connell, Gregory P Giambrone, Aisha Baqai, Sudhir Diwan
OBJECTIVE: Constipation is a common adverse effect in patients requiring long-term opioid therapy for pain control. Methylnaltrexone, a quaternary peripheral mu-opioid receptor antagonist, is an effective treatment of opioid induced constipation (OIC) without affecting centrally mediated analgesia. Our objective was to conduct a review and meta-analysis to evaluate the efficacy of methylnaltrexone for treatment of OIC, as well as to provide a clinical discussion regarding newly developed alternatives and provide the current treatment algorithm utilized at our institution...
2016: Postgraduate Medicine
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