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JOURNAL ARTICLE
José Roberto Vargas-Villanueva, Filiberto Gutiérrez-Gutiérrez, Mariana Garza-Ontiveros, Sendar Daniel Nery-Flores, Lizeth Guadalupe Campos-Múzquiz, Dagoberto Vazquez-Obregón, Raul Rodriguez-Herrera, Lissethe Palomo-Ligas
Giardia lamblia is a globally distributed protozoan parasite that causes intestinal disease. Recently, there is an increase in refractory cases of giardiasis to chemotherapeutic agents, and drugs available cause side effects that may limit its use or cause therapeutic non-compliance. Therefore, search for alternative and less harmful drugs to treat giardiasis is an important task. In this sense, resveratrol (RSV) is a polyphenol with a wide range of pharmacological effects such as antimicrobial, anticarcinogenic and antioxidant...
September 16, 2023: Acta Tropica
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JOURNAL ARTICLE
Micaela White, Lauren Hisatomi, Alex Villegas, Dagoberto Pina, Alec Garfinkel, Garima Agrawal, Nisha Punatar, Barton L Wise, Polly Teng, Hai Le
PURPOSE: This study determined whether initiation of pharmacologic treatment was delayed for newly diagnosed osteoporosis patients during the COVID-19 pandemic. METHODS: 1,189 patients ≥50 years with newly diagnosed osteoporosis using dual-energy x-ray absorptiometry (DXA) screening at a single academic institution were included. Patients with previous osteoporosis were excluded. Patients diagnosed between March 1, 2018-January 31, 2020 (pre-pandemic cohort, n = 576) were compared to those diagnosed between March 1, 2020-January 31, 2022 (pandemic cohort, n = 613)...
2023: PloS One
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JOURNAL ARTICLE
Ana Beatriz Ayroza Galvão Ribeiro Gomes, Laila Kulsvehagen, Patrick Lipps, Alessandro Cagol, Nuria Cerdá-Fuertes, Tradite Neziraj, Julia Flammer, Jasmine Lerner, Anne-Catherine Lecourt, Nina de Oliveira S Siebenborn, Rosa Cortese, Sabine Schaedelin, Vinicius Andreoli Schoeps, Aline de Moura Brasil Matos, Natalia Trombini Mendes, Clarissa Dos Reis Pereira, Mario Luiz Ribeiro Monteiro, Samira Luisa Dos Apóstolos-Pereira, Patrick Schindler, Claudia Chien, Carolin Schwake, Ruth Schneider, Thivya Pakeerathan, Orhan Aktas, Urs Fischer, Matthias Mehling, Tobias Derfuss, Ludwig Kappos, Ilya Ayzenberg, Marius Ringelstein, Friedemann Paul, Dagoberto Callegaro, Jens Kuhle, Athina Papadopoulou, Cristina Granziera, Anne-Katrin Pröbstel
IMPORTANCE: Differential diagnosis of patients with seronegative demyelinating central nervous system (CNS) disease is challenging. In this regard, evidence suggests that immunoglobulin (Ig) A plays a role in the pathogenesis of different autoimmune diseases. Yet little is known about the presence and clinical relevance of IgA antibodies against myelin oligodendrocyte glycoprotein (MOG) in CNS demyelination. OBJECTIVE: To investigate the frequency of MOG-IgA and associated clinical features in patients with demyelinating CNS disease and healthy controls...
September 1, 2023: JAMA Neurology
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JOURNAL ARTICLE
Janintzitzic López-Niño, Montserrat Padilla-Orozco, Aidán Ortega, Verónica Alejandra Cáceres-Chávez, Dagoberto Tapia, Antonio Laville, Elvira Galarraga, José Bargas
We employed the whole-cell patch-clamp method and ChAT-Cre mice to study the electrophysiological attributes of cholinergic neurons in the external globus pallidus. Most neurons were inactive, although approximately 20% displayed spontaneous firing, including burst firing. The resting membrane potential, the whole neuron input resistance, the membrane time constant and the total neuron membrane capacitance were also characterized. The current-voltage relationship showed time-independent inward rectification without a "sag"...
August 1, 2023: Neuroscience
#25
JOURNAL ARTICLE
José Escalona, Dagoberto Soto, Vanessa Oviedo, Elizabeth Rivas, Nicolás Severino, Eduardo Kattan, Max Andresen, Sebastián Bravo, Roque Basoalto, María Consuelo Bachmann, Kwok-Yin Wong, Nicolás Pavez, Alejandro Bruhn, Guillermo Bugedo, Jaime Retamal
Different techniques have been proposed to measure antibiotic levels within the lung parenchyma; however, their use is limited because they are invasive and associated with adverse effects. We explore whether beta-lactam antibiotics could be measured in exhaled breath condensate collected from heat and moisture exchange filters (HMEFs) and correlated with the concentration of antibiotics measured from bronchoalveolar lavage (BAL). We designed an observational study in patients undergoing mechanical ventilation, which required a BAL to confirm or discard the diagnosis of pneumonia...
July 17, 2023: Journal of Personalized Medicine
#26
JOURNAL ARTICLE
Andrew T Hale, Dagoberto Estevez-Ordonez, Jana Badrani, Wen Sha, Anastasia Arynchyna-Smith, Monisha Goyal, Ismail Mohamed, Pongkiat Kankirawatana, Curtis J Rozzelle, Jeffrey P Blount
OBJECTIVE: Hemispherectomy is highly effective for patients with medically refractory epilepsy (MRE) arising from a single hemisphere. Recently, the Hemispherectomy Outcome Prediction Scale (HOPS) was developed as a prediction tool for seizure freedom after hemispherectomy. The authors' goal was to perform a validation study to determine the generalizability of the HOPS score. METHODS: The authors present an observational, retrospective, 20-year, single-institution, two-surgeon experience using the lateral peri-insular hemispherectomy approach to validate the HOPS score...
October 1, 2023: Journal of Neurosurgery. Pediatrics
#27
JOURNAL ARTICLE
Rafael T P da Silva, Dagoberto O Silva, Paulo F M de Oliveira, Ronan Bellabarba, Peter Johnston, Joost Smit, Jarle Holt, Mike Betham, Liane Marcia Rossi
The performance of mechanochemically synthesized supported bimetallic AgAu nanoalloy catalysts was evaluated in the oxidative cleavage of methyl oleate, a commonly available unsaturated bio-derived raw material. An extensive screening of supports (SiO2, C, ZrO2, Al2O3), metallic ratios (Ag:Au), reaction times, temperatures, and use of solvents was carried out. The performance was optimized towards productivity and selectivity for the primary cleavage products (aldehydes and oxoesters). The optimal conditions were achieved in the absence of solvent, using Ag8Au92/SiO2 as catalyst, at 80 °C, reaction time of 1 h, substrate to catalyst = 555 and 10 bar of molecular oxygen...
July 27, 2023: ChemPlusChem
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JOURNAL ARTICLE
Travis J Atchley, Dagoberto Estevez-Ordonez, Nicholas M B Laskay, Borna E Tabibian, Mark R Harrigan
BACKGROUND AND OBJECTIVES: Endovascular thrombectomy has previously been reserved for patients with small to medium acute ischemic strokes. Three recent randomized control trials have demonstrated functional benefit and risk profiles for thrombectomy in large-volume ischemic strokes. The primary objective of the meta-analysis was to determine the combined benefit of endovascular thrombectomy in patients with large-volume ischemic strokes and to determine the risk of adverse events after treatment...
January 1, 2024: Neurosurgery
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Rodrigo Dahia Fernandes, Thais de Souza Andrade, Rony C Preti, Leandro C Zacharias, Guilherme Diogo Silva, Leandro Tavares Lucato, Samira L Apóstolos-Pereira, Dagoberto Callegaro, Mário Luiz R Monteiro
Retinal complications in patients with inflammatory optic neuritis (ON) are generally related to post-infectious neuroretinitis and are considered uncommon in autoimmune/demyelinating ON, whether isolated or caused by multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD). More recently, however, cases with retinal complications have been reported in subjects positive for myelin oligodendrocyte glycoprotein (MOG) antibodies. We report a 53-year-old woman presenting with severe bilateral ON associated with a focal area of paracentral acute middle maculopathy (PAMM) in one eye...
2023: Neuro-ophthalmology
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JOURNAL ARTICLE
Diego Cardoso Fragoso, Luana Michelli Oliveira de Paula Salles, Samira Luisa Apóstolos Pereira, Dagoberto Callegaro, Douglas Kazutoshi Sato, Carolina de Medeiros Rimkus
BACKGROUND: There is clinical and radiological overlap among demyelinating diseases. However, their pathophysiological mechanisms are different and carry distinct prognoses and treatment demands. OBJECTIVE: To investigate magnetic resonance imaging (MRI) features of patients with myelin-oligodendrocyte glycoprotein associated disease (MOGAD), antibody against aquaporin-4(AQP-4)-immunoglobulin G-positive neuromyelitis optica spectrum disorder (AQP4-IgG NMOSD), and double-seronegative patients...
June 2023: Arquivos de Neuro-psiquiatria
#31
REVIEW
Agustí Alentorn, Giulia Berzero, Harry Alexopoulos, John Tzartos, Germán Reyes Botero, Andrea Morales Martínez, Sergio Muñiz-Castrillo, Alberto Vogrig, Bastien Joubert, Francisco A García Jiménez, Dagoberto Cabrera, José Vladimir Tobon, Carolina Delgado, Patricio Sandoval, Mónica Troncoso, Lorna Galleguillos, Marine Giry, Marion Benazra, Isaias Hernández Verdin, Maëlle Dade, Géraldine Picard, Véronique Rogemond, Nicolas Weiss, Marinos C Dalakas, Pierre-Yves Boëlle, Jean-Yves Delattre, Jérôme Honnorat, Dimitri Psimaras
Anti-NMDAR encephalitis has been associated with multiple antigenic triggers (i.e., ovarian teratomas, prodromal viral infections) but whether geographic, climatic, and environmental factors might influence disease risk has not been explored yet. We performed a systematic review and a meta-analysis of all published papers reporting the incidence of anti-NMDAR encephalitis in a definite country or region. We performed several multivariate spatial autocorrelation analyses to analyze the spatial variations in the incidence of anti-NMDA encephalitis depending on its geographical localization and temperature...
May 25, 2023: Biomedicines
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JOURNAL ARTICLE
Sara Terrim, Guilherme Diogo Silva, Fernando Cavalcanti de Sá E Benevides Falcao, Clarissa Dos Reis Pereira, Thais de Souza Andrade Benassi, Ida Fortini, Marcia Rubia Rodrigues Gonçalves, Luiz Henrique Martins Castro, Luiz Roberto Comerlatti, Carolina de Medeiros Rimkus, Tarso Adoni, Samira Luisa Apostolos Pereira, Mário Luiz Monteiro, Dagoberto Callegaro
Optic neuritis (ON) admits diverse differential diagnoses. Petzold proposed diagnostic criteria for ON in 2022, although real-world application of these criteria is missing. We conducted a retrospective review of patients with ON. We classified patients into definite or possible ON, and into groups A (typical neuritis), B (painless), or C (binocular) and estimated the frequency of etiologies for each group. We included 77 patients, with 62% definite and 38% possible ON. CRION and NMOSD-AQP4 negative-ON were less commonly seen in definite ON...
August 15, 2023: Journal of Neuroimmunology
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JOURNAL ARTICLE
Sociodemographic Characteristics of Patients Undergoing Surgery for Metastatic Disease of the Spine.
Dagoberto Piña, Venina Kalistratova, Zachary Boozé, Wyatt Vander Voort, Keegan Conry, Jeffrey Fine, Joseph Holland, Joseph Wick, Brandon Ortega, Yashar Javidan, Rolando Roberto, Eric Klineberg, Shaina Lipa, Hai Le
INTRODUCTION: Some patients, particularly those who are socioeconomically deprived, are diagnosed with primary and/or metastatic cancer only after presenting to the emergency department. Our objective was to determine sociodemographic characteristics of patients undergoing surgery for metastatic spine disease at our institution. METHODS: This retrospective case series included patients 18 years and older who presented to the emergency department with metastatic spine disease requiring surgery...
June 12, 2023: Journal of the American Academy of Orthopaedic Surgeons
#34
JOURNAL ARTICLE
Jeong In Yang, Dagoberto Sepúlveda, Irina Vardia, Jakob Skov, Louise Goksøyr, Adam F Sander, Niels Lorenzen
The Gram-negative bacterium A. salmonicida is the causal agent of furunculosis and used to be one of the most loss-causing bacterial infections in the salmonid aquaculture industry with a mortality rate of about 90% until the 1990s, when an inactivated vaccine with mineral oil as adjuvant was successfully implemented to control the disease. However, the use of this vaccine is associated with inflammatory side effects in the peritoneal cavity as well as autoimmune reactions in Atlantic salmon, and incomplete protection has been reported in rainbow trout...
2023: Frontiers in Immunology
#35
JOURNAL ARTICLE
Eileen K Nehme, Divya A Patel, Dagoberto Cortez, Sophie M Morse, Kirkland Schuessler, Lauren E Gulbas
INTRODUCTION: A qualitative picture of the health care experiences prior to pregnancy can inform patient-centered strategies to optimize preconception health. This study describes health care utilization and experiences and how health care costs were covered in the year prior to pregnancy in a population of primarily Hispanic women with low income. METHODS: Pregnant participants were recruited from 5 Federally Qualified Health Center clinics. Semistructured interviews included questions about health care in the year prior to pregnancy...
June 7, 2023: Journal of Midwifery & Women's Health
#36
JOURNAL ARTICLE
Dagoberto Estevez-Ordonez, Moaaz Abdelrashid, Elizabeth Coffee, Nicholas M B Laskay, Travis J Atchley, Rati Chkheidze, John B Fiveash, James M Markert, Mina Lobbous, Brandon M Maveal, Louis Burt Nabors
BACKGROUND: Glioblastoma (GBM) is the most common malignant primary brain tumor. Emerging reports have suggested that racial and socioeconomic disparities influence the outcomes of patients with GBM. No studies to date have investigated these disparities controlling for isocitrate dehydrogenase (IDH) mutation and O-6-methylguanine-DNA methyltransferase (MGMT) status. METHODS: Adult patients with GBM were retrospectively reviewed at a single institution from 2008 to 2019...
May 28, 2023: Cancer
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JOURNAL ARTICLE
Guilherme Diogo Silva, Sara Terrim, Fernando Cavalcantide Sá E Benevides Falcão, Maria Alice Pimentel Falcão, Cleuber Esteves Chaves, Samira Apóstolos-Pereira, Ida Fortini, Márcia Rúbia Rodrigues Gonçalves, Luiz Roberto Comerlatti, Luiz Henrique Martins Castro, Dagoberto Callegaro, Mário Luiz Ribeiro Monteiro
BACKGROUND: Optic neuritis (ON), a major cause of visual impairment in young adults, is generally associated with rapid visual recovery when treated with intravenous methylprednisolone treatment (IVMPT). However, the optimal duration of such treatment is unknown, ranging from three to seven days in clinical practice. We aimed to compare the visual recovery in patients treated with 5-day or 7-day duration IVMPT. METHODS: We performed a retrospective cohort study of consecutive patients with ON in São Paulo, Brazil, from 2016 to 2021...
April 26, 2023: Multiple Sclerosis and related Disorders
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JOURNAL ARTICLE
Marco A Lana-Peixoto, Natália C Talim, Dagoberto Callegaro, Vanessa Daccath Marques, Alfredo Damasceno, Jefferson Becker, Marcus Vinicius Magno Gonçalves, Henry Sato
BACKGROUND: Neuromyelitis optica spectrum disorders (NMOSD) most commonly cause severe disability which is related to disease attacks. However, some patients retain good neurological function for a long time after disease onset. OBJECTIVES: To determine the frequency, demographic and the clinical features of good outcome NMOSD, and analyze their predictive factors. METHODS: We selected patients who met the 2015 International Panel for NMOSD diagnostic criteria from seven MS Centers...
July 2023: Multiple Sclerosis and related Disorders
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JOURNAL ARTICLE
Greg Gilles, Arjun Vohra, Dagoberto Robles, Mihra S Taljanovic, Erin L Ashbeck, Chelsea Caruso, Jeffrey Duryea, Edward J Bedrick, Ali Guermazi, C Kent Kwoh
Effusion-synovitis (ES) is recognized as a component of osteoarthritis, creating a need for rapid methods to assess ES on MRI. We describe the development and reliability of an efficient single-slice semi-automated quantitative approach to measure ES. We used two samples from the Osteoarthritis Initiative (OAI): 50 randomly selected OAI participants with radiographic osteoarthritis (i.e., Kellgren-Lawrence (KL) grade 2 or 3) and a subset from the Foundation for the National Institutes of Health Osteoarthritis Biomarker study...
April 4, 2023: Journal of Clinical Medicine
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JOURNAL ARTICLE
John S Stein, Dagoberto Estevez-Ordonez, Nicholas M B Laskay, Travis J Atchley, James M Markert
No abstract text is available yet for this article.
April 2023: World Neurosurgery
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