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https://www.readbyqxmd.com/read/28877561/a-severe-phenotype-of-kennedy-disease-associated-with-a-very-large-cag-repeat-expansion
#1
João L O Madeira, Alexandre B C Souza, Flavia S Cunha, Rafael L Batista, Nathalia L Gomes, Andresa S Rodrigues, Frederico Mennucci de Haidar Jorge, Gerson Chadi, Dagoberto Callegaro, Berenice B Mendonca, Elaine M F Costa, Sorahia Domenice
No abstract text is available yet for this article.
September 6, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28765025/congenital-malformations-of-the-central-nervous-system-in-rural-western-honduras-a-6-year-report-on-trends
#2
Dagoberto Estevez-Ordonez, Michael C Dewan, Michael J Feldman, Eleazar E Montalvan-Sanchez, Daniela M Montalvan-Sanchez, Aida A Rodriguez-Murillo, Samuel A Urrutia-Argueta, Charlotte B Cherry, Douglas R Morgan, Roberto Alvarez-Rodriguez, Christopher M Bonfield
BACKGROUND: Central nervous system (CNS) malformations, including neural tube defects (NTDs), are the second most common type of birth defects worldwide and are major causes of childhood disability and mortality. We report the first analysis of birth prevalence in Western Honduras of CNS malformations including NTDs over 6 consecutive years. METHODS: Data from all patients with congenital CNS malformations and total live births for the period 2010-2015 were obtained through institution and regional registries from all 3 public referral hospitals in Western Honduras, representing 67 municipalities...
November 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28394975/-risk-factors-for-acute-kidney-injury-in-patients-treated-with-polymyxin-b-experience-from-139-cases-at-a-tertiary-university-hospital-in-colombia
#3
Johanna Osorio, Jackeline Barreto, Claudia F Samboni, Lina A Cándelo, Luis C Álvarez, Susana Benavidez, Roso P Téllez, Dagoberto Santofimio, Jorge A Ramos, Carlos A Gómez
BACKGROUND: The rise of infections caused by multidrug-resistant Gram negative bacilli (MDR-GNB), added to paucity of newer therapy, have led to increase polymyxin B use, despite adverse renal toxicity profile. AIM: To determine the incidence and risk factors associated to acute kidney injury (AKI) and polymyxin B use, in patients with infections caused by MDR-GNB. METHODS: A retrospective cohort, with a nested case-control study of adults who received polymyxin B for more than 48 hours at a tertiary university hospital in Colombia (2011-2015) was performed...
February 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28336026/viscoelastic-studies-effective-tools-for-trauma-and-surgical-resuscitation-efforts
#4
Dagoberto Salinas
Trauma-induced coagulopathy (TIC) is an abrupt disruption of all hemostatic components of coagulation resulting from severe tissue injury and hypoperfusion. The effective management of TIC has remained elusive to clinicians using traditional laboratory methods, challenging efforts to improve outcomes related to uncontrolled bleeding. Recent initiatives have aimed to reduce TIC-associated morbidity and mortality, further invoking trauma experts to explore innovative modalities in the field of viscoelastic studies, such as thromboelastography (TEG) and rotational thromboelastometry (ROTEM)...
April 2017: AORN Journal
https://www.readbyqxmd.com/read/28095172/characterizing-the-nature-of-scan-results-discussions-insights-into-why-patients-misunderstand-their-prognosis
#5
Sarguni Singh, Dagoberto Cortez, Douglas Maynard, James F Cleary, Lori DuBenske, Toby C Campbell
INTRODUCTION: Patients with incurable cancer have poor prognostic awareness. We present a detailed analysis of the dialogue between oncologists and patients in conversations with prognostic implications. METHODS: A total of 128 audio-recorded encounters from a large multisite trial were obtained, and 64 involved scan results. We used conversation analysis, a qualitative method for studying human interaction, to analyze typical patterns and conversational devices...
March 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28000469/tablas-de-referencia-para-aspectos-antropom%C3%A3-tricos-y-de-condici%C3%A3-n-f%C3%A3-sica-en-estudiantes-varones-chilenos-de-10-a-14-a%C3%A3-os
#6
Claudio Hernández Mosqueira, Dagoberto Hernández Vasquez, Alexis Caniuqueo Vargas, Humberto Castillo Quezada, Sandro Fernandes Da Silva, Gustavo Pavez-Adasme, Cristian Martínez Salazar, Jaime Cárcamo-Oyarzún, José Fernandes Filho
Introducción: Chile en las últimas décadas ha experimentado un cambio en su perfil epidemiológico nutricional, pasando de una situación caracterizada por una elevada prevalencia de desnutrición y enfermedades infecciosas/parasitarias a otro completamente distinto, en donde las enfermedades crónicas y degenerativas presentan una elevada prevalencia.Objetivo: el objetivo del estudio es elaborar tablas de referencia de aspectos antropométricos y de condición física en estudiantes varones de 10 a 14 años de la ciudad de Chillán...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27978769/genetic-analysis-of-patients-with-familial-and-sporadic-amyotrophic-lateral-sclerosis-in-a-brazilian-research-center
#7
Gerson Chadi, Jessica Ruivo Maximino, Frederico Mennucci de Haidar Jorge, FabríCIO Castro dE Borba, Joyce Meire Gilio, Dagoberto Callegaro, Camila GalvãO Lopes, Samantha Nakamura Dos Santos, Gabriela Natania Sales Rebelo
OBJECTIVE: To investigate gene mutations in familial form (FALS) and sporadic form (SALS) of amyotrophic lateral sclerosis (ALS) in a highly miscegenated population. METHODS: Frequencies of mutations in the C9orfF72, TARDBP, SOD1, FUS and VAPB genes were investigated in a cohort of FALS (n = 39) and SALS (n = 189) subjects from the Research Centre of the University of São Paulo School of Medicine. All patients were subjected to C9orf72 and TARDBP analyses...
December 15, 2016: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/27648139/liquid-extracorporeal-carbon-dioxide-removal-use-of-tham-tris-hydroxymethyl-aminomethane-coupled-to-hemofiltration-to-control-hypercapnic-acidosis-in-a-porcine-model-of-protective-mechanical-ventilation
#8
Pablo Tapia, Felipe Lillo, Dagoberto Soto, Leslie Escobar, Felipe Simon, Karina Hernández, Leyla Alegría, Alejandro Bruhn
A promising approach to facilitate protective mechanical ventilation is the use of extracorporeal CO2 removal techniques. Several strategies based on membrane gas exchangers have been developed. However, these techniques are still poorly available. The goal of this study was to assess the efficacy and safety of THAM infusion coupled to hemofiltration for the management of hypercapnic acidosis. A severe respiratory acidosis was induced in seven anesthetized pigs. Five of them were treated with THAM 8-mmol·kg(-1)·h(-1) coupled to hemofiltration (THAM+HF group) at 100 mL·kg(-1)·h(-1)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27518295/american-society-of-anesthesiologists-score-as-a-predictive-tool-to-optimize-blood-ordering-for-intraoperative-transfusion-in-orthopaedic-trauma-cases
#9
Vasanth Sathiyakumar, Dagoberto Estevez-Ordonez, Rachel V Thakore, Young M Lee, Jesse M Ehrenfeld, William T Obremskey, Manish K Sethi
The objective of this study was to determine the clinical factors that are predictors for intraoperative transfusion in orthopaedic trauma patients. A retrospective chart review of patients admitted to a level I trauma center with isolated fractures was conducted. Variables such as gender, height, weight, body mass index, American Society of Anesthesiologists (ASA) classification, and medical comorbidities were assessed to determine likelihood of blood transfusion. A total of 1819 patients with isolated fractures were identified...
2016: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/27480413/effects-of-dexmedetomidine-and-esmolol-on-systemic-hemodynamics-and-exogenous-lactate-clearance-in-early-experimental-septic-shock
#10
Glenn Hernández, Pablo Tapia, Leyla Alegría, Dagoberto Soto, Cecilia Luengo, Jussara Gomez, Nicolas Jarufe, Pablo Achurra, Rolando Rebolledo, Alejandro Bruhn, Ricardo Castro, Eduardo Kattan, Gustavo Ospina-Tascón, Jan Bakker
BACKGROUND: Persistent hyperlactatemia during septic shock is multifactorial. Hypoperfusion-related anaerobic production and adrenergic-driven aerobic generation together with impaired lactate clearance have been implicated. An excessive adrenergic response could contribute to persistent hyperlactatemia and adrenergic modulation might be beneficial. We assessed the effects of dexmedetomidine and esmolol on hemodynamics, lactate generation, and exogenous lactate clearance during endotoxin-induced septic shock...
August 2, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27398166/extracorporeal-membrane-oxygenation-improves-survival-in-a-novel-24-hour-pig-model-of-severe-acute-respiratory-distress-syndrome
#11
Joaquín Araos, Leyla Alegría, Patricio García, Felipe Damiani, Pablo Tapia, Dagoberto Soto, Tatiana Salomon, Felipe Rodriguez, Macarena Amthauer, Benjamín Erranz, Gabriel Castro, Pamela Carreño, Tania Medina, Jaime Retamal, Pablo Cruces, Guillermo Bugedo, Alejandro Bruhn
Extracorporeal membrane oxygenation (ECMO) is increasingly being used to treat severe acute respiratory distress syndrome (ARDS). However, there is limited clinical evidence about how to optimize the technique. Experimental research can provide an alternative to fill the actual knowledge gap. The purpose of the present study was to develop and validate an animal model of acute lung injury (ALI) which resembled severe ARDS, and which could be successfully supported with ECMO. Eighteen pigs were randomly allocated into three groups: sham, ALI, and ALI + ECMO...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27360902/camk-in-skeletal-muscle-stimulated-by-caffeine-to-promote-endurance-adaptation-2077-board-229-june-2-2-00-pm-3-30-pm
#12
Dagoberto Pina, Keith Baar
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27299823/-what-are-the-propensity-scores
#13
REVIEW
Dagoberto Ojeda, Rocío Gómez, Álvaro Burgos
Medical research is constantly looking for causality. Among study designs, randomized controlled trials are the most reliable way to estimate causal effects but are not always feasible. When this is the case, observational studies must be performed but this type of design unavoidably implies bias. Propensity scores, defined as the probability to receive a treatment conditional to a set of covariables allows to overcome confusion bias when searching for causal effects.
March 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27135538/global-rebalancing-of-cellular-resources-by-pleiotropic-point-mutations-illustrates-a-multi-scale-mechanism-of-adaptive-evolution
#14
Jose Utrilla, Edward J O'Brien, Ke Chen, Douglas McCloskey, Jacky Cheung, Harris Wang, Dagoberto Armenta-Medina, Adam M Feist, Bernhard O Palsson
Pleiotropic regulatory mutations affect diverse cellular processes, posing a challenge to our understanding of genotype-phenotype relationships across multiple biological scales. Adaptive laboratory evolution (ALE) allows for such mutations to be found and characterized in the context of clear selection pressures. Here, several ALE-selected single-mutation variants in RNA polymerase (RNAP) of Escherichia coli are detailed using an integrated multi-scale experimental and computational approach. While these mutations increase cellular growth rates in steady environments, they reduce tolerance to stress and environmental fluctuations...
April 27, 2016: Cell Systems
https://www.readbyqxmd.com/read/27108611/retraction-notice-to-energy-direct-inputs-and-greenhouse-gas-emissions-of-the-main-industrial-trawl-fishery-of-brazil
#15
Dagoberto Port, Jose Angel Alvarez Perez, João Thadeu de Menezes
No abstract text is available yet for this article.
April 15, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27068561/energy-direct-inputs-and-greenhouse-gas-emissions-of-the-main-industrial-trawl-fishery-of-brazil
#16
Dagoberto Port, Jose Angel Alvarez Perez, João Thadeu de Menezes
This study provides first-time estimates of direct fuel inputs and greenhouse gas emissions produced by the trawl fishing fleet operating off southeastern and southern Brazil. Analyzed data comprised vessel characteristics, landings, fishing areas and trawling duration of 10,144 fishing operations monitored in Santa Catarina State from 2003 to 2011. Three main fishing strategies were differentiated: 'shrimp trawling', 'slope trawling' and 'pair trawling'. Jointly these operations burned over 141.5millionl of diesel to land 342...
June 15, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27054895/can-vhs-virus-bypass-the-protective-immunity-induced-by-dna-vaccination-in-rainbow-trout
#17
Dagoberto Sepúlveda, Niels Lorenzen
DNA vaccines encoding viral glycoproteins have been very successful for induction of protective immunity against diseases caused by rhabdoviruses in cultured fish species. However, the vaccine concept is based on a single viral gene and since RNA viruses are known to possess high variability and adaptation capacity, this work aimed at evaluating whether viral haemorrhagic septicaemia virus (VHSV), an RNA virus and member of Rhabdoviridae family, was able to evade the protective immune response induced by the DNA vaccination of rainbow trout...
2016: PloS One
https://www.readbyqxmd.com/read/27027024/terrible-triad-of-the-elbow-evaluation-of-surgical-treatment
#18
Leandro Cardoso Gomide, Dagoberto de Oliveira Campos, José Maria Ribeiro de Sá, Marcelo Rangel Pamfílio de Sousa, Thiago Correa do Carmo, Fernando Brandão Andrada
OBJECTIVES: To evaluate the epidemiology of and surgical results from treating elbow fracture-dislocations, including only the cases in which dislocation is associated with fracture of the coronoid process and the radial head (terrible triad). METHODS: Nineteen patients were evaluated: 12 males and 7 females. The medical records were analyzed to gather data about the mechanism of injury, fracture pattern, time elapsed until surgery and type of procedure applied...
July 2011: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/27009599/cost-analysis-of-multiple-sclerosis-in-brazil-a-cross-sectional-multicenter-study
#19
MULTICENTER STUDY
Nilceia Lopes da Silva, Maira L S Takemoto, Alfredo Damasceno, Yara D Fragoso, Alessandro Finkelsztejn, Jefferson Becker, Marcus V M Gonçalves, Charles Tilbery, Enedina M L de Oliveira, Dagoberto Callegaro, Fernanda C Boulos
BACKGROUND: Multiple sclerosis (MS) is a central nervous system disease associated with irreversible progression of disability, which imposes a substantial socioeconomic onus. The objective of this study was to determine the economic impact of multiple sclerosis from the Brazilian household and healthcare system perspectives. Secondary objectives were to assess the impact of fatigue on daily living and health-related quality of life (HRQL) of MS patients. METHODS: This is a cross-sectional study in which Brazilian eligible patients attending eight major MS specialized sites answered an interview capturing data on demographics, disease characteristics and severity, comorbidities, resource utilization, fatigue, utilities and health-related quality of life from November/2011 to May/2012 ...
March 24, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27000256/hypovitaminosis-d-association-with-disease-activity-in-relapsing-remitting-multiple-sclerosis-in-brazil
#20
MULTICENTER STUDY
Jefferson Becker, Dagoberto Callegaro, Marco Aurélio Lana-Peixoto, Natália Talim, Tamara Vidaletti, Marcelo de Paula Corrêa, Irenio Gomes
Multiple sclerosis (MS) onset is believed to result from a combination of environmental and genetic factors. A prevailing theory addresses the influence of hypovitaminosis D in the development of MS. This research aimed to study the association between vitamin D serum levels and MS, as a prognostic and risk factor for the development and progression of the disease. A cross-sectional multicenter study was conducted in patients with relapsing-remitting MS (n=67), according to the revised McDonald criteria (2010), accompanied in three MS centers in different Brazilian states...
April 15, 2016: Journal of the Neurological Sciences
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