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https://www.readbyqxmd.com/read/29739287/collaborative-care-management-associated-with-improved-depression-outcomes-in-patients-with-personality-disorders-compared-to-usual-primary-care
#1
Jeremy J Solberg, Mark E Deyo-Svendsen, Kelsey R Nylander, Elliot J Bruhl, Dagoberto Heredia, Kurt B Angstman
BACKGROUND: The use of a collaborative care management (CCM) model can dramatically improve short- and long-term treatment outcomes for patients with major depressive disorder (MDD). Patients with comorbid personality disorder (PD) may experience poorer treatment outcomes for MDD. Our study seeks to examine the differences in MDD treatment outcomes for patients with comorbid PD when using a CCM approach rather than usual care (UC). METHODS: In our retrospective cohort study, we reviewed the records of 9614 adult patients enrolled in our depression registry with the clinical diagnosis MDD and the diagnosis of PD (Yes/No)...
January 2018: Journal of Primary Care & Community Health
https://www.readbyqxmd.com/read/29734646/evaluation-of-meropenem-pharmacokinetics-in-an-experimental-acute-respiratory-distress-syndrome-ards-model-during-extracorporeal-membrane-oxygenation-ecmo-by-using-a-penp-%C3%AE-lactamase-biosensor
#2
Max Andresen, Joaquin Araos, Kwok-Yin Wong, Yun-Chung Leung, Lok-Yan So, Wai-Ting Wong, Salvador Cabrera, Camila Silva, Leyla Alegria, Alejandro Bruhn, Dagoberto Soto
INTRODUCTION: The use of antibiotics is mandatory in patients during extracorporeal membrane oxygenation (ECMO) support. Clinical studies have shown high variability in the antibiotic concentrations, as well as sequestration of them by the ECMO circuit, suggesting that the doses and/or interval administration used during ECMO may not be adequate. Thus, a fast response sensor to estimate antibiotic concentrations in this setting would contribute to improve dose adjustments. The biosensor PenP has been shown to have a dynamic range, sensitivity and specificity useful for pharmacokinetic (PK) tests in healthy subjects...
May 4, 2018: Sensors
https://www.readbyqxmd.com/read/29670575/mog-igg-associated-optic-neuritis-encephalitis-and-myelitis-lessons-learned-from-neuromyelitis-optica-spectrum-disorder
#3
REVIEW
Giordani Rodrigues Dos Passos, Luana Michelli Oliveira, Bruna Klein da Costa, Samira Luisa Apostolos-Pereira, Dagoberto Callegaro, Kazuo Fujihara, Douglas Kazutoshi Sato
Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been found in some cases diagnosed as seronegative neuromyelitis optica spectrum disorder (NMOSD). MOG-IgG allowed the identification of a subgroup with a clinical course distinct from that of NMOSD patients who are seropositive for aquaporin-4-IgG antibodies. MOG-IgG is associated with a wider clinical phenotype, not limited to NMOSD, with the majority of cases presenting with optic neuritis (ON), encephalitis with brain demyelinating lesions, and/or myelitis...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29668680/mitochondrial-nicotinamide-adenine-dinucleotide-reduced-nadh-oxidation-links-the-tricarboxylic-acid-tca-cycle-with-methionine-metabolism-and-nuclear-dna-methylation
#4
Oswaldo A Lozoya, Inmaculada Martinez-Reyes, Tianyuan Wang, Dagoberto Grenet, Pierre Bushel, Jianying Li, Navdeep Chandel, Richard P Woychik, Janine H Santos
Mitochondrial function affects many aspects of cellular physiology, and, most recently, its role in epigenetics has been reported. Mechanistically, how mitochondrial function alters DNA methylation patterns in the nucleus remains ill defined. Using a cell culture model of induced mitochondrial DNA (mtDNA) depletion, in this study we show that progressive mitochondrial dysfunction leads to an early transcriptional and metabolic program centered on the metabolism of various amino acids, including those involved in the methionine cycle...
April 18, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29614096/abundance-diversity-and-domain-architecture-variability-in-prokaryotic-dna-binding-transcription-factors
#5
Ernesto Perez-Rueda, Rafael Hernandez-Guerrero, Mario Alberto Martinez-Nuñez, Dagoberto Armenta-Medina, Israel Sanchez, J Antonio Ibarra
Gene regulation at the transcriptional level is a central process in all organisms, and DNA-binding transcription factors, known as TFs, play a fundamental role. This class of proteins usually binds at specific DNA sequences, activating or repressing gene expression. In general, TFs are composed of two domains: the DNA-binding domain (DBD) and an extra domain, which in this work we have named "companion domain" (CD). This latter could be involved in one or more functions such as ligand binding, protein-protein interactions or even with enzymatic activity...
2018: PloS One
https://www.readbyqxmd.com/read/29554549/the-protective-effects-of-high-education-levels-on-cognition-in-different-stages-of-multiple-sclerosis
#6
Carolina de Medeiros Rimkus, Isabella Maria Bello Avolio, Eliane Correa Miotto, Samira Apostolos Pereira, Maria Fernanda Mendes, Dagoberto Callegaro, Claudia da Costa Leite
BACKGROUND: Low-education attainment is associated with worse cognitive performance in multiple sclerosis (MS) patients, and possibly with a lower cognitive reserve and/or increased inflammatory activity. Cognitive reserve refers to the capability of a source of intellectual enrichment in attenuating a negative effect of a disease-related factor; while the inflammatory activity is often related to T2-lesion load (T2-LL) increase. OBJECTIVE: To disentangle the effects of cognitive reserve and an increased T2-LL in MS-patients with low-education levels...
March 6, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29340417/rose-bengal-catalysed-photo-induced-selenylation-of-indoles-imidazoles-and-arenes-a-metal-free-approach
#7
Sumbal Saba, Jamal Rafique, Marcelo S Franco, Alex R Schneider, Leandro Espíndola, Dagoberto O Silva, Antonio L Braga
In this report, the highly efficient Rose Bengal-catalysed C(sp2 )-H selenylation of indoles, imidazoles and arenes was achieved using a half molar equiv. of diorganoyl diselenides. This metal-free, photo-induced protocol resulted in selenylated products in good to excellent yields. The reaction features are high yields, an atom-economic, gram-scalable and metal-free approach, and applicability to different biologically relevant (hetero)arenes.
February 7, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29210595/evaluation-of-anionic-surfactant-removal-by-anaerobic-degradation-of-commercial-laundry-wastewater-and-domestic-sewage
#8
Clara Vieira de Faria, Tiago Palladino Delforno, Dagoberto Yukio Okada, Maria Bernadete Amâncio Varesche
An expanded granular sludge bed reactor was evaluated for the anaerobic digestion of commercial laundry wastewater and domestic sewage focused on the removal of linear alkylbenzene sulfonate (LAS). The reactor was operated in three stages, all under mesophilic conditions and with a hydraulic retention time of 36 h. At stage I, the laundry wastewater was diluted with tap water (influent: 15.3 ± 4.9 mg LAS/L); at stage II, 50% of the feed volume was domestic sewage and 50% was a mixture of tap water and laundry wastewater (influent: 15...
December 13, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28877561/a-severe-phenotype-of-kennedy-disease-associated-with-a-very-large-cag-repeat-expansion
#9
João L O Madeira, Alexandre B C Souza, Flavia S Cunha, Rafael L Batista, Nathalia L Gomes, Andresa S Rodrigues, Frederico Mennucci de Haidar Jorge, Gerson Chadi, Dagoberto Callegaro, Berenice B Mendonca, Elaine M F Costa, Sorahia Domenice
No abstract text is available yet for this article.
January 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/28765025/congenital-malformations-of-the-central-nervous-system-in-rural-western-honduras-a-6-year-report-on-trends
#10
MULTICENTER STUDY
Dagoberto Estevez-Ordonez, Michael C Dewan, Michael J Feldman, Eleazar E Montalvan-Sanchez, Daniela M Montalvan-Sanchez, Aida A Rodriguez-Murillo, Samuel A Urrutia-Argueta, Charlotte B Cherry, Douglas R Morgan, Roberto Alvarez-Rodriguez, Christopher M Bonfield
BACKGROUND: Central nervous system (CNS) malformations, including neural tube defects (NTDs), are the second most common type of birth defects worldwide and are major causes of childhood disability and mortality. We report the first analysis of birth prevalence in Western Honduras of CNS malformations including NTDs over 6 consecutive years. METHODS: Data from all patients with congenital CNS malformations and total live births for the period 2010-2015 were obtained through institution and regional registries from all 3 public referral hospitals in Western Honduras, representing 67 municipalities...
November 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28394975/-risk-factors-for-acute-kidney-injury-in-patients-treated-with-polymyxin-b-experience-from-139-cases-at-a-tertiary-university-hospital-in-colombia
#11
Johanna Osorio, Jackeline Barreto, Claudia F Samboni, Lina A Cándelo, Luis C Álvarez, Susana Benavidez, Roso P Téllez, Dagoberto Santofimio, Jorge A Ramos, Carlos A Gómez
BACKGROUND: The rise of infections caused by multidrug-resistant Gram negative bacilli (MDR-GNB), added to paucity of newer therapy, have led to increase polymyxin B use, despite adverse renal toxicity profile. AIM: To determine the incidence and risk factors associated to acute kidney injury (AKI) and polymyxin B use, in patients with infections caused by MDR-GNB. METHODS: A retrospective cohort, with a nested case-control study of adults who received polymyxin B for more than 48 hours at a tertiary university hospital in Colombia (2011-2015) was performed...
February 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28336026/viscoelastic-studies-effective-tools-for-trauma-and-surgical-resuscitation-efforts
#12
Dagoberto Salinas
Trauma-induced coagulopathy (TIC) is an abrupt disruption of all hemostatic components of coagulation resulting from severe tissue injury and hypoperfusion. The effective management of TIC has remained elusive to clinicians using traditional laboratory methods, challenging efforts to improve outcomes related to uncontrolled bleeding. Recent initiatives have aimed to reduce TIC-associated morbidity and mortality, further invoking trauma experts to explore innovative modalities in the field of viscoelastic studies, such as thromboelastography (TEG) and rotational thromboelastometry (ROTEM)...
April 2017: AORN Journal
https://www.readbyqxmd.com/read/28095172/characterizing-the-nature-of-scan-results-discussions-insights-into-why-patients-misunderstand-their-prognosis
#13
Sarguni Singh, Dagoberto Cortez, Douglas Maynard, James F Cleary, Lori DuBenske, Toby C Campbell
INTRODUCTION: Patients with incurable cancer have poor prognostic awareness. We present a detailed analysis of the dialogue between oncologists and patients in conversations with prognostic implications. METHODS: A total of 128 audio-recorded encounters from a large multisite trial were obtained, and 64 involved scan results. We used conversation analysis, a qualitative method for studying human interaction, to analyze typical patterns and conversational devices...
March 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28000469/tablas-de-referencia-para-aspectos-antropom%C3%A3-tricos-y-de-condici%C3%A3-n-f%C3%A3-sica-en-estudiantes-varones-chilenos-de-10-a-14-a%C3%A3-os
#14
Claudio Hernández Mosqueira, Dagoberto Hernández Vasquez, Alexis Caniuqueo Vargas, Humberto Castillo Quezada, Sandro Fernandes Da Silva, Gustavo Pavez-Adasme, Cristian Martínez Salazar, Jaime Cárcamo-Oyarzún, José Fernandes Filho
Introducción: Chile en las últimas décadas ha experimentado un cambio en su perfil epidemiológico nutricional, pasando de una situación caracterizada por una elevada prevalencia de desnutrición y enfermedades infecciosas/parasitarias a otro completamente distinto, en donde las enfermedades crónicas y degenerativas presentan una elevada prevalencia.Objetivo: el objetivo del estudio es elaborar tablas de referencia de aspectos antropométricos y de condición física en estudiantes varones de 10 a 14 años de la ciudad de Chillán...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27978769/genetic-analysis-of-patients-with-familial-and-sporadic-amyotrophic-lateral-sclerosis-in-a-brazilian-research-center
#15
Gerson Chadi, Jessica Ruivo Maximino, Frederico Mennucci de Haidar Jorge, Fabrício Castro de Borba, Joyce Meire Gilio, Dagoberto Callegaro, Camila Galvão Lopes, Samantha Nakamura Dos Santos, Gabriela Natania Sales Rebelo
OBJECTIVE: To investigate gene mutations in familial form (FALS) and sporadic form (SALS) of amyotrophic lateral sclerosis (ALS) in a highly miscegenated population. METHODS: Frequencies of mutations in the C9orfF72, TARDBP, SOD1, FUS and VAPB genes were investigated in a cohort of FALS (n = 39) and SALS (n = 189) subjects from the Research Centre of the University of São Paulo School of Medicine. All patients were subjected to C9orf72 and TARDBP analyses...
May 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/27648139/liquid-extracorporeal-carbon-dioxide-removal-use-of-tham-tris-hydroxymethyl-aminomethane-coupled-to-hemofiltration-to-control-hypercapnic-acidosis-in-a-porcine-model-of-protective-mechanical-ventilation
#16
Pablo Tapia, Felipe Lillo, Dagoberto Soto, Leslie Escobar, Felipe Simon, Karina Hernández, Leyla Alegría, Alejandro Bruhn
A promising approach to facilitate protective mechanical ventilation is the use of extracorporeal CO2 removal techniques. Several strategies based on membrane gas exchangers have been developed. However, these techniques are still poorly available. The goal of this study was to assess the efficacy and safety of THAM infusion coupled to hemofiltration for the management of hypercapnic acidosis. A severe respiratory acidosis was induced in seven anesthetized pigs. Five of them were treated with THAM 8-mmol·kg(-1)·h(-1) coupled to hemofiltration (THAM+HF group) at 100 mL·kg(-1)·h(-1)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27518295/american-society-of-anesthesiologists-score-as-a-predictive-tool-to-optimize-blood-ordering-for-intraoperative-transfusion-in-orthopaedic-trauma-cases
#17
Vasanth Sathiyakumar, Dagoberto Estevez-Ordonez, Rachel V Thakore, Young M Lee, Jesse M Ehrenfeld, William T Obremskey, Manish K Sethi
The objective of this study was to determine the clinical factors that are predictors for intraoperative transfusion in orthopaedic trauma patients. A retrospective chart review of patients admitted to a level I trauma center with isolated fractures was conducted. Variables such as gender, height, weight, body mass index, American Society of Anesthesiologists (ASA) classification, and medical comorbidities were assessed to determine likelihood of blood transfusion. A total of 1819 patients with isolated fractures were identified...
2016: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/27480413/effects-of-dexmedetomidine-and-esmolol-on-systemic-hemodynamics-and-exogenous-lactate-clearance-in-early-experimental-septic-shock
#18
Glenn Hernández, Pablo Tapia, Leyla Alegría, Dagoberto Soto, Cecilia Luengo, Jussara Gomez, Nicolas Jarufe, Pablo Achurra, Rolando Rebolledo, Alejandro Bruhn, Ricardo Castro, Eduardo Kattan, Gustavo Ospina-Tascón, Jan Bakker
BACKGROUND: Persistent hyperlactatemia during septic shock is multifactorial. Hypoperfusion-related anaerobic production and adrenergic-driven aerobic generation together with impaired lactate clearance have been implicated. An excessive adrenergic response could contribute to persistent hyperlactatemia and adrenergic modulation might be beneficial. We assessed the effects of dexmedetomidine and esmolol on hemodynamics, lactate generation, and exogenous lactate clearance during endotoxin-induced septic shock...
August 2, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27398166/extracorporeal-membrane-oxygenation-improves-survival-in-a-novel-24-hour-pig-model-of-severe-acute-respiratory-distress-syndrome
#19
Joaquín Araos, Leyla Alegría, Patricio García, Felipe Damiani, Pablo Tapia, Dagoberto Soto, Tatiana Salomon, Felipe Rodriguez, Macarena Amthauer, Benjamín Erranz, Gabriel Castro, Pamela Carreño, Tania Medina, Jaime Retamal, Pablo Cruces, Guillermo Bugedo, Alejandro Bruhn
Extracorporeal membrane oxygenation (ECMO) is increasingly being used to treat severe acute respiratory distress syndrome (ARDS). However, there is limited clinical evidence about how to optimize the technique. Experimental research can provide an alternative to fill the actual knowledge gap. The purpose of the present study was to develop and validate an animal model of acute lung injury (ALI) which resembled severe ARDS, and which could be successfully supported with ECMO. Eighteen pigs were randomly allocated into three groups: sham, ALI, and ALI + ECMO...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27360902/camk-in-skeletal-muscle-stimulated-by-caffeine-to-promote-endurance-adaptation-2077-board-229-june-2-2-00-pm-3-30-pm
#20
Dagoberto Pina, Keith Baar
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
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