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Pablo Tapia, Felipe Lillo, Dagoberto Soto, Leslie Escobar, Felipe Simon, Karina Hernández, Leyla Alegría, Alejandro Bruhn
A promising approach to facilitate protective mechanical ventilation is the use of extracorporeal CO2 removal techniques. Several strategies based on membrane gas exchangers have been developed. However, these techniques are still poorly available. The goal of this study was to assess the efficacy and safety of THAM infusion coupled to hemofiltration for the management of hypercapnic acidosis. A severe respiratory acidosis was induced in seven anesthetized pigs. Five of them were treated with THAM 8-mmol·kg(-1)·h(-1) coupled to hemofiltration (THAM+HF group) at 100 mL·kg(-1)·h(-1)...
2016: American Journal of Translational Research
Vasanth Sathiyakumar, Dagoberto Estevez-Ordonez, Rachel V Thakore, Young M Lee, Jesse M Ehrenfeld, William T Obremskey, Manish K Sethi
The objective of this study was to determine the clinical factors that are predictors for intraoperative transfusion in orthopaedic trauma patients. A retrospective chart review of patients admitted to a level I trauma center with isolated fractures was conducted. Variables such as gender, height, weight, body mass index, American Society of Anesthesiologists (ASA) classification, and medical comorbidities were assessed to determine likelihood of blood transfusion. A total of 1819 patients with isolated fractures were identified...
2016: Journal of Surgical Orthopaedic Advances
Glenn Hernández, Pablo Tapia, Leyla Alegría, Dagoberto Soto, Cecilia Luengo, Jussara Gomez, Nicolas Jarufe, Pablo Achurra, Rolando Rebolledo, Alejandro Bruhn, Ricardo Castro, Eduardo Kattan, Gustavo Ospina-Tascón, Jan Bakker
BACKGROUND: Persistent hyperlactatemia during septic shock is multifactorial. Hypoperfusion-related anaerobic production and adrenergic-driven aerobic generation together with impaired lactate clearance have been implicated. An excessive adrenergic response could contribute to persistent hyperlactatemia and adrenergic modulation might be beneficial. We assessed the effects of dexmedetomidine and esmolol on hemodynamics, lactate generation, and exogenous lactate clearance during endotoxin-induced septic shock...
August 2, 2016: Critical Care: the Official Journal of the Critical Care Forum
Joaquín Araos, Leyla Alegría, Patricio García, Felipe Damiani, Pablo Tapia, Dagoberto Soto, Tatiana Salomon, Felipe Rodriguez, Macarena Amthauer, Benjamín Erranz, Gabriel Castro, Pamela Carreño, Tania Medina, Jaime Retamal, Pablo Cruces, Guillermo Bugedo, Alejandro Bruhn
Extracorporeal membrane oxygenation (ECMO) is increasingly being used to treat severe acute respiratory distress syndrome (ARDS). However, there is limited clinical evidence about how to optimize the technique. Experimental research can provide an alternative to fill the actual knowledge gap. The purpose of the present study was to develop and validate an animal model of acute lung injury (ALI) which resembled severe ARDS, and which could be successfully supported with ECMO. Eighteen pigs were randomly allocated into three groups: sham, ALI, and ALI + ECMO...
2016: American Journal of Translational Research
Dagoberto Pina, Keith Baar
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Dagoberto Ojeda, Rocío Gómez, Álvaro Burgos
Medical research is constantly looking for causality. Among study designs, randomized controlled trials are the most reliable way to estimate causal effects but are not always feasible. When this is the case, observational studies must be performed but this type of design unavoidably implies bias. Propensity scores, defined as the probability to receive a treatment conditional to a set of covariables allows to overcome confusion bias when searching for causal effects.
March 2016: Revista Médica de Chile
Jose Utrilla, Edward J O'Brien, Ke Chen, Douglas McCloskey, Jacky Cheung, Harris Wang, Dagoberto Armenta-Medina, Adam M Feist, Bernhard O Palsson
Pleiotropic regulatory mutations affect diverse cellular processes, posing a challenge to our understanding of genotype-phenotype relationships across multiple biological scales. Adaptive laboratory evolution (ALE) allows for such mutations to be found and characterized in the context of clear selection pressures. Here, several ALE-selected single-mutation variants in RNA polymerase (RNAP) of Escherichia coli are detailed using an integrated multi-scale experimental and computational approach. While these mutations increase cellular growth rates in steady environments, they reduce tolerance to stress and environmental fluctuations...
April 27, 2016: Cell Systems
Dagoberto Port, Jose Angel Alvarez Perez, João Thadeu de Menezes
No abstract text is available yet for this article.
April 15, 2016: Marine Pollution Bulletin
Dagoberto Port, Jose Angel Alvarez Perez, João Thadeu de Menezes
This study provides first-time estimates of direct fuel inputs and greenhouse gas emissions produced by the trawl fishing fleet operating off southeastern and southern Brazil. Analyzed data comprised vessel characteristics, landings, fishing areas and trawling duration of 10,144 fishing operations monitored in Santa Catarina State from 2003 to 2011. Three main fishing strategies were differentiated: 'shrimp trawling', 'slope trawling' and 'pair trawling'. Jointly these operations burned over 141.5millionl of diesel to land 342...
June 15, 2016: Marine Pollution Bulletin
Dagoberto Sepúlveda, Niels Lorenzen
DNA vaccines encoding viral glycoproteins have been very successful for induction of protective immunity against diseases caused by rhabdoviruses in cultured fish species. However, the vaccine concept is based on a single viral gene and since RNA viruses are known to possess high variability and adaptation capacity, this work aimed at evaluating whether viral haemorrhagic septicaemia virus (VHSV), an RNA virus and member of Rhabdoviridae family, was able to evade the protective immune response induced by the DNA vaccination of rainbow trout...
2016: PloS One
Leandro Cardoso Gomide, Dagoberto de Oliveira Campos, José Maria Ribeiro de Sá, Marcelo Rangel Pamfílio de Sousa, Thiago Correa do Carmo, Fernando Brandão Andrada
OBJECTIVES: To evaluate the epidemiology of and surgical results from treating elbow fracture-dislocations, including only the cases in which dislocation is associated with fracture of the coronoid process and the radial head (terrible triad). METHODS: Nineteen patients were evaluated: 12 males and 7 females. The medical records were analyzed to gather data about the mechanism of injury, fracture pattern, time elapsed until surgery and type of procedure applied...
July 2011: Revista Brasileira de Ortopedia
Nilceia Lopes da Silva, Maira L S Takemoto, Alfredo Damasceno, Yara D Fragoso, Alessandro Finkelsztejn, Jefferson Becker, Marcus V M Gonçalves, Charles Tilbery, Enedina M L de Oliveira, Dagoberto Callegaro, Fernanda C Boulos
BACKGROUND: Multiple sclerosis (MS) is a central nervous system disease associated with irreversible progression of disability, which imposes a substantial socioeconomic onus. The objective of this study was to determine the economic impact of multiple sclerosis from the Brazilian household and healthcare system perspectives. Secondary objectives were to assess the impact of fatigue on daily living and health-related quality of life (HRQL) of MS patients. METHODS: This is a cross-sectional study in which Brazilian eligible patients attending eight major MS specialized sites answered an interview capturing data on demographics, disease characteristics and severity, comorbidities, resource utilization, fatigue, utilities and health-related quality of life from November/2011 to May/2012 ...
2016: BMC Health Services Research
Jefferson Becker, Dagoberto Callegaro, Marco Aurélio Lana-Peixoto, Natália Talim, Tamara Vidaletti, Marcelo de Paula Corrêa, Irenio Gomes
Multiple sclerosis (MS) onset is believed to result from a combination of environmental and genetic factors. A prevailing theory addresses the influence of hypovitaminosis D in the development of MS. This research aimed to study the association between vitamin D serum levels and MS, as a prognostic and risk factor for the development and progression of the disease. A cross-sectional multicenter study was conducted in patients with relapsing-remitting MS (n=67), according to the revised McDonald criteria (2010), accompanied in three MS centers in different Brazilian states...
April 15, 2016: Journal of the Neurological Sciences
Bruna Antinori Vignola da Fonseca, Cristiana Borges Pereira, Frederico Jorge, Renata Simm, Samira Apostolos-Pereira, Dagoberto Callegaro
The purpose of this study was to determine the relationship between perception of verticality and balance disorders in multiple sclerosis patients. We evaluated patients and healthy controls. Patients were divided into two groups according to their risk of fall, with or without risk of fall, measured by a Dynamic Gait Index scale. Graviceptive perception was assessed using the subjective visual vertical test. Patients with risk of fall showed worse perception than those without risk of fall, p < 0.001. Misperception of verticality was correlated with the dynamic gait index scores (p < 0...
February 2016: Arquivos de Neuro-psiquiatria
Tania del Mar Pedreros-Sierra, Dagoberto M Arrieta-Prieto, Paola A Mejía-Falla
We studied anatomical and functional aspects of the reproductive system of females of the Magdalena river stingray Potamotrygon magdalenae using microscopic and macroscopic analysis of each organ. Although the reproductive tract was fully functional on both side, the left organs possibly have a greater contribution to reproductive success, because left ovary and uterus were more developed and had higher number of oocytes and embryos, respectively, than the right ones. This species has histotrophic viviparity given by the presence of uterine trophonemata and by glandular character in pregnant and postpartum females...
May 2016: Journal of Morphology
Max Andresen, Kwok-Yin Wong, Yun-Chung Leung, Wai-Ting Wong, Pak-Ho Chan, Max Andresen-Vasquez, Leyla Alegria, Camila Silva, Pablo Tapia, Patricio Downey, Dagoberto Soto
Recently, Wong et al. have successfully developed a fluorescent biosensor based on the PenPC β-lactamase which changes its intrinsic fluorescence in presence of β-lactam antibiotics (BLAs). Here, we studied systematically this correlation among the fluorescence change of the biosensor and the concentration of different BLAs aimed at developing a novel method for estimating the concentration of a wide range of BLAs. This method showed high precision and specificity and very low interference from clinically relevant samples...
2016: BioMed Research International
Dagoberto Soto, Camila Silva, Max Andresen V, Natalia Soto, Kwok-Yin Wong, Max Andresen
The pharmacokinetics of antibiotics, especially in severely ill patients, may be profoundly altered due to multiple pathophysiological changes. Recent studies have shown that empiric dosing recommendations for ICU patients are inadequate to effectively treat a broad range of susceptible organisms and need to be reconsidered. Therapeutic drug monitoring (TDM) is an important mean for optimizing drug utilization and doses for the purpose of improving the clinical effectiveness. However, it is very challenging to quantify plasma antibiotic concentrations in clinical situations as a routine practice, because of the high costs and complexities associated with advanced instrumental techniques...
August 2015: Revista Médica de Chile
Dagoberto Esparza-Castro, Francisco Javier Andrade-Ancira, Carlos Adrián Merelo-Arias, Miguel Cruz, Adán Valladares-Salgado
Diabetes mellitus is a complex and chronical disease, which represents one of the biggest health issues the world, with alarming numbers and constantly increasing it demands the creation of new diagnostic, therapeutic and preventive techniques. The complete Genome Wide Association (GWA) in type 2 diabetes (T2D) is a useful research tool for the characterization of genetic markers and physiopathogenic pathways, with potential clinical utility either as a T2D risk prediction or its complications. In Mexico is necessary to make a comprehensive dissection of the genetic background of T2D by the complex genetic mosaic of our population and increase the knowledge of the molecular and pathophysiological mechanisms that lead to this condition...
September 2015: Revista Médica del Instituto Mexicano del Seguro Social
Enedina Maria Lobato de Oliveira, Renata Faria Simm, Gorana Dasic, Marília Mamprim de Morais, Samira Luiza dos Apostolos Perreira, Dagoberto Callegaro
Objective Analyze the demographics, clinical characteristics, efficacy and safety of natalizumab treatment in Brazilian patients with multiple sclerosis (MS) followed up for at least 12 months, in two tertiary MS care centers in São Paulo.Method We evaluated the effect of natalizumab treatment on annualized relapse rate and disability progression in 75 patients with MS treated with natalizumab for at least 12 months. A subgroup analysis was performed to evaluate efficacy of natalizumab treatment in patients with Expanded Disability Status Scale (EDSS) ≤ 3...
September 2015: Arquivos de Neuro-psiquiatria
Marcos C B Oliveira, Douglas Kazutoshi Sato, Herval R Soares-Neto, Leandro T Lucato, Dagoberto Callegaro, Ricardo Nitrini, Raphael S S Medeiros, Tatsuro Misu, Kazuo Fujihara, Luiz H Castro
BACKGROUND: Association of leukoencephalopathy and atypical mycobacteriosis has been rarely reported. We present a case that is relevant for its unusual presentation and because it may shed further light on the pathogenic mechanisms underlying reversible encephalopathies. CASE REPORT: We report the case of a Hispanic 64-year-old woman with cognitive decline and extensive leukoencephalopathy. Magnetic resonance imaging revealed white-matter lesions with increased water diffusivity, without blood-brain-barrier disruption...
2015: BMC Neurology
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