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Phosphate binders

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https://www.readbyqxmd.com/read/29148025/a-3-day-diary-of-dietary-protein-and-calorie-intake-by-serum-phosphate-concentration-and-binder-use-in-hemodialysis-patients
#1
Meiry J S Araújo, Luciana F Silva, Maria T S Martins, Cacia M Matos, Marcelo B Lopes, Rilma F S Santos, LarissaS Santos, Angiolina C Kraychete, Márcia T S Martins, Fernanda A Silva, Antonio A Lopes
INTRODUCTION: The use of phosphate binders to control hyperphosphatemia may allow diets less restricted in protein and calories for maintenance hemodialysis (MHD) patients. The study compared intakes of protein, calorie and phosphate among MHD patients with different serum phosphate concentrations, taking into account binder use. The hypothesis was that low serum phosphate would be associated with low intakes of protein and calories only in patients not on binders. METHODS: A cross-sectional study of 443 patients enrolled in the Prospective Study of the Prognosis of Chronic Hemodialysis Patients (PROHEMO) in Salvador, Brazil, with stratified sampling on serum phosphate: ≤3...
November 4, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29121565/dynamics-of-metals-in-backfill-of-a-phosphate-mine-of-guiyang-china-using-a-three-step-sequential-extraction-technique
#2
Ying Shi, Lei Gan, Xibing Li, Suya He, Cheng Sun, Li Gao
Phosphate rock in Guiyang (Southwest of China) is used for the phosphate production, and hence generating a by-product phosphogypsum (PG). From 2007, part of the PG was used as main raw material for cemented backfill. The main objective of this paper is to investigate the geochemical evolution of metals before and after the PG inclusion into the backfill matrix. A sequential extraction procedure was selected to determine the chemical speciation of metals in phosphate rock, PG, binder and field backfill samples...
November 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/29119720/phage-display-on-anti-infective-target-dxs-led-to-an-acceptor-substrate-competitive-peptidic-inhibitor
#3
Alessio Marcozzi, Tiziana Masini, Di Zhu, Diego Pesce, Boris Illarionov, Markus Fischer, Andreas Herrmann, Anna Katharina Herta Hirsch
Enzymes of the 2-C-methyl-d-erythritol-4-phosphate pathway for the biosynthesis of isoprenoid precursors are validated drug targets. By performing phage display on 1-deoxy-d-xylulose 5-phosphate synthase (DXS), which catalyzes the first step of this pathway, we discovered several peptide hits and recognized false positive hits. The enriched peptide binder P12 emerged as substrate (d-glyceraldehyde 3-phosphate) competitive against Deinococcus radiodurans DXS. The result indicates possible overlapping of cofactor- and acceptor-substrate-binding pockets, and provides inspiration for the design of inhibitors of DXS with a unique and novel mechanism...
November 8, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29105169/photomodulation-of-dna-templated-supramolecular-assemblies
#4
Jenifer Rubio-Magnieto, Tuan-Anh Phan, Mathieu Fossépré, Valérie Matot, Jérémie Knoops, Thibaut Jarrosson, Pascal Dumy, Francoise Serein-Spirau, Claude Niebel, Sébastien Ulrich, Mathieu Surin
A new type of DNA ligand that contains a phosphate-binding group and a photoresponsive azobenzene moiety is reported. When the azobenzene is in trans configuration, the ligand binds to the minor groove of a double-stranded DNA, whereas it partially desorbs upon trans-cis isomerization with light. The ability to photoswitch the ligand upon interaction with DNA is evidenced by (chir)optical signatures, and deciphered by the differences of binding geometry, stability, and dynamics of the DNA/ligand complexes for the two isomers...
November 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29074818/randomized-clinical-trial-of-sevelamer-carbonate-on-serum-klotho-and-fibroblast-growth-factor-23-in-ckd
#5
Sophie Liabeuf, Jean-Philippe Ryckelynck, Najeh El Esper, Pablo Ureña, Christian Combe, Bertrand Dussol, Denis Fouque, Philippe Vanhille, Luc Frimat, Eric Thervet, Romuald Mentaverri, Dominique Prié, Gabriel Choukroun
BACKGROUND AND OBJECTIVES: Epidemiologic studies suggest that higher serum phosphaturic hormone fibroblast growth factor 23 levels are associated with increase morbidity and mortality. The aim of the FGF23 Reduction Efficacy of a New Phosphate Binder in CKD Trial was to evaluate the effect of sevelamer carbonate on serum C-terminal fibroblast growth factor 23 levels in normophosphatemic patients with CKD stage 3b/4. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Patients with CKD, eGFR between 45 and 15 ml/min per 1...
October 26, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29064180/a-service-review-to-assess-if-innovative-intensive-phosphate-dietary-education-can-help-reduce-phosphate-levels-to-the-recommended-range-in-a-hemodialysis-population
#6
Eileen A Duff, Fiona M Chawke
INTRODUCTION: Studies suggest that hemodialysis (HD) patients are less likely to adhere to phosphate dietary restriction than to potassium, sodium, or fluid restriction. It is particularly important that dietary education is provided appropriately, consistently, and reinforced regularly to encourage compliance with diet and phosphate-binder regimens. Patient awareness of the consequences of a chronically raised phosphate and its treatment is associated with lower serum phosphate levels...
October 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29064176/calciphylaxis-after-parathyroidectomy
#7
Sathish Karmegam, Anupkumar Shetty
A 60-year-old African American man with end stage renal disease on hemodialysis (HD) for the past 2.5 years developed severe hyperparathyroidism. Other past medical history included atrial fibrillation, type II diabetes mellitus, hypertension, gout, pericardial effusion needing pericardial window, deep vein thrombosis, mitral insufficiency, and cardiomyopathy with implantable cardioversion device placement. His parathyroid hormone (PTH) level peaked at 4,191 pg/mL despite being on cinacalcet, sevelamer, and paricalcitol...
October 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29064141/the-role-of-dietary-phosphate-restriction-in-chronic-kidney-disease
#8
Grahame J Elder, Avya Malik, Kelly Lambert
BACKGROUND AND OBJECTIVES: Patients with progressive chronic kidney disease (CKD) develop positive phosphate balance that is associated with increased cardiovascular risk and mortality. Modification of dietary phosphate is a commonly used strategy to improve outcomes but is complicated by the need for adequate dietary protein. Surprisingly, the evidence for patient-level benefits from phosphate restriction is tenuous, and the justification for using any phosphate binder for pre-dialysis patients is questionable...
October 24, 2017: Nephrology
https://www.readbyqxmd.com/read/29063671/magnesium-supplementation-a-consideration-in-dialysis-patients
#9
EDITORIAL
Mugurel Apetrii, Adrian Covic, Ziad A Massy
Even though disorders of magnesium (Mg) balance are common in dialyzed patients, this cation is often neglected. Many factors interfere with serum magnesium including diet, medications (eg, antacids or phosphate binders), and the dialysis prescription. Mg supplementation may help reduce serum phosphate concentration, PTH, and interfere with vascular calcification and bone mineralization. It could also decrease the all-cause and cardiovascular mortalities, although the results of current studies are conflicting...
October 23, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/29058057/effects-of-lanthanum-carbonate-on-coronary-artery-calcification-and-cardiac-abnormalities-after-initiating-hemodialysis
#10
Hideki Fujii, Keiji Kono, Kentaro Nakai, Shunsuke Goto, Tatsuya Nishii, Atsushi Kono, Shinichi Nishi
It is known that calcium-containing phosphate binders are more closely associated with the progression of vascular calcification than non-calcium-containing phosphate binders. In this study, we investigated the effect of the non-calcium-containing phosphate binder, lanthanum carbonate on the progression of coronary artery calcification and cardiovascular abnormalities compared to that of calcium-containing phosphate binder in chronic kidney disease patients during the early period after initiating hemodialysis...
October 20, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29044984/3d-printed-calcium-phosphate-and-poly-caprolactone-composites-with-improved-mechanical-properties-and-preserved-microstructure
#11
Joseph B Vella, Ryan P Trombetta, Michael D Hoffman, Jason Inzana, Hani Awad, Danielle S W Benoit
Biphasic calcium phosphate scaffolds formed via 3D printing technology to exhibit porosity and chemical resorbability to promote osseointegration often lack the strength and toughness required to withstand loading in bone tissue engineering applications. Herein, sintering and CaP:poly(caprolactone) (PCL) composite formation were explored to improve 3D printed scaffold strength and toughness. Hydroxyapatite and α-tricalcium phosphate (α-TCP) biphasic calcium powders were printed using phosphoric acid binder, which generated monetite and hydroxyapatite scaffolds...
October 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29044930/effect-of-incident-nocturnal-home-hemodialysis-versus-incident-continuous-ambulatory-peritoneal-dialysis-on-employment-rate-clinical-and-laboratory-outcomes-a-1-year-retrospective-observation-study
#12
John Wing Li, Joseph Ho Sing Wong, Wai Leung Chak, Ka Foon Chau
INTRODUCTION: While studies demonstrated favorable outcomes of nocturnal home hemodialysis (NHHD), direct comparison on employment rate, clinical and laboratory outcomes between the NHHD and continuous ambulatory peritoneal dialysis (CAPD) had not been previously performed. METHODS: A 1-year retrospective observation study was performed in 20 incidents alternate night NHHD and 81 incident CAPD patients of Chinese ethnicity, who were sex, diabetic status, and Charlson comorbidity index matched, but not age due to our center's age limit for NHHD enrollment...
October 18, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28993865/two-year-cortical-and-trabecular-bone-loss-in-ckd-5d-biochemical-and-clinical-predictors
#13
H H Malluche, M-C Monier-Faugere, G Blomquist, D L Davenport
This prospective two-year study of patients on chronic dialysis measured changes in bone mineral density (BMD). Patients with higher baseline BMD and shorter dialysis vintage lost more bone. Treatment with anti-hypertensives acting on the central nervous system was protective against bone loss. Baseline serum levels of sclerostin and bone-specific alkaline phosphatase predicted bone loss. INTRODUCTION: This prospective 2-year study of chronic kidney disease on dialysis (CKD-5D) patients assessed trabecular and cortical bone loss at the hip and spine and examined potential demographic, clinical, and serum biochemical predictors of bone loss...
October 9, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28985540/influence-of-lead-on-stabilization-solidification-by-ordinary-portland-cement-and-magnesium-phosphate-cement
#14
Yan-Shuai Wang, Jian-Guo Dai, Lei Wang, Daniel C W Tsang, Chi Sun Poon
Inorganic binder-based stabilization/solidification (S/S) of Pb-contaminated soil is a commonly used remediation approach. This paper investigates the influences of soluble Pb species on the hydration process of two types of inorganic binders: ordinary Portland cement (OPC) and magnesium potassium phosphate cement (MKPC). The environmental leachability, compressive strength, and setting time of the cement products are assessed as the primary performance indicators. The mechanisms of Pb involved in the hydration process are analyzed through X-ray diffraction (XRD), hydration heat evolution, and thermogravimetric analyses...
September 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/28970367/a-pilot-study-of-okkidney-a-phosphate-counting-application-in-patients-on-peritoneal-dialysis
#15
Rameez Imtiaz, Katherine Atkinson, Julien Guerinet, Kumanan Wilson, Jullie Leidecker, Deborah Zimmerman
BACKGROUND: Hyperphosphatemia is associated with adverse outcomes in patients treated with peritoneal dialysis (PD). We have shown that a fixed meal phosphate binder dosing schedule is not appropriate. The purpose of this study was to evaluate the beta version of OkKidney, a phosphate counting app that matches meal phosphate content with binder dose. METHODS: A convenience sample of adult patients treated with PD completed a pre-survey that included the technology readiness index (TRI 2...
September 28, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28941764/kdoqi-us-commentary-on-the-2017-kdigo-clinical-practice-guideline-update-for-the-diagnosis-evaluation-prevention-and%C3%A2-treatment-of-chronic-kidney-disease-mineral-and-bone%C3%A2-disorder-ckd-mbd
#16
Tamara Isakova, Thomas L Nickolas, Michelle Denburg, Sri Yarlagadda, Daniel E Weiner, Orlando M Gutiérrez, Vinod Bansal, Sylvia E Rosas, Sagar Nigwekar, Jerry Yee, Holly Kramer
Chronic kidney disease-mineral and bone disorder (CKD-MBD) encompasses laboratory and bone abnormalities and vascular calcification and has deleterious effects on clinical outcomes. KDOQI (Kidney Disease Outcomes Quality Initiative), an initiative of the National Kidney Foundation, addressed this issue with the publication of a clinical practice guideline for bone metabolism and disease in CKD in 2003, and 2 years later, a new definition and classification scheme for CKD-MBD was developed following a KDIGO (Kidney Disease: Improving Global Outcomes) Controversies Conference...
September 20, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28939921/pathophysiology-and-treatment-of-cardiovascular-disease-in-pediatric-chronic-kidney-disease
#17
REVIEW
Nadine Khouzam, Katherine Wesseling-Perry
Life expectancy in patients with all stages of chronic kidney disease (CKD) falls far short of that in the general population. Cardiovascular disease is the leading cause of mortality in pediatric patients with CKD. In contrast to the intimal atherosclerotic lesions that characterize cardiovascular disease in the general population, vascular endothelial dysfunction, medial arterial calcification, and cardiac dysfunction contribute to cardiovascular pathological conditions in CKD. The pathogenesis of these lesions, the origins of which can be identified in the absence of traditional cardiovascular risk factors, is incompletely understood...
September 22, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28916883/different-post-processing-conditions-for-3d-bioprinted-%C3%AE-tricalcium-phosphate-scaffolds
#18
Liciane Sabadin Bertol, Rodrigo Schabbach, Luis Alberto Loureiro Dos Santos
The development of 3D printing hardware, software and materials has enabled the production of bone substitute scaffolds for tissue engineering. Calcium phosphates cements, such as those based on α-tricalcium phosphate (α-TCP), have recognized properties of osteoinductivity, osteoconductivity and resorbability and can be used to 3D print scaffolds to support and induce tissue formation and be replaced by natural bone. At present, however, the mechanical properties found for 3D printed bone scaffolds are only satisfactory for non-load bearing applications...
September 15, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28914962/impaired-phosphate-tolerance-revealed-with-an-acute-oral-challenge
#19
Mandy E Turner, Christine A White, Wilma M Hopman, Emilie C Ward, Paul S Jeronimo, Michael A Adams, Rachel M Holden
Elevated serum phosphate is consistently linked with cardiovascular disease (CVD) events and mortality in the setting of normal and impaired kidney function. However, serum phosphate does not often exceed the upper limit of normal until glomerular filtration rate (GFR) falls below 30 mL/min/m(2) . It was hypothesized that the response to an oral, bioavailable phosphate load will unmask impaired phosphate tolerance, a maladaptation not revealed by baseline serum phosphate concentrations. In this study rats with varying kidney function as well as normo-phosphatemic human subjects, with inulin-measured GFR (13...
September 15, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28900759/efficacy-and-safety-of-sevelamer-carbonate-in-hyperphosphatemic-pediatric-patients-with-chronic-kidney-disease
#20
Sahar Fathallah-Shaykh, Dorota Drozdz, Joseph Flynn, Randall Jenkins, Katherine Wesseling-Perry, Sarah J Swartz, Craig Wong, Beverly Accomando, Gerald F Cox, Bradley A Warady
BACKGROUND: Treatment for hyperphosphatemia in chronic kidney disease (CKD) involves dietary control of phosphorus intake, dialysis, and treatment with oral phosphate binders, none of which were approved by the Federal Food and Drug Administration in pediatric patients at the time of this study. METHODS: This was a phase 2, multicenter study (NCT01574326) with a 2-week, randomized, placebo-controlled, fixed-dose period (FDP) followed by a 6-month, single-arm, open-label, dose-titration period (DTP), with the aim to evaluate the safety and efficacy of sevelamer carbonate (SC) in hyperphosphatemic pediatric patients with CKD...
September 12, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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