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Stem cell donation

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https://www.readbyqxmd.com/read/28326208/a-child-as-a-donor-for-hematopoietic-stem-cell-transplantation-bioethical-justification-a-case-study-on-sickle-cell-disease
#1
Andrea Z Pereira, Ricardo Hellman, Nelson Hamerschlak, Andrea Kondo, Polianna Mara Rodrigues de Souza, Wilson Leite Pedreira, Luiz Fernando Alves Lima Mantovani, Eduardo Juan Troster, Henrique Grunspun, Marco Aurélio Scarpinella Bueno
Hematopoietic stem cell transplantation (HSCT) is an important treatment option for children with severe and refractory sickle cell disease (SCD) with debilitating clinical complications. HSCT with cells from the bone marrow of a HLA-identical sibling used in SCD has a low mortality risk, high cure rate, and high event-free survival rate after a median follow-up of 5-6 years. However, matched donors are found in only about 20% of the patients. A boy aged 8 years with SCD had a sister, <2 years old, a fully compatible donor...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28255771/amniotic-membrane-in-ophthalmology-properties-preparation-storage-and-indications-for-grafting-a-review
#2
REVIEW
Katerina Jirsova, Gary L A Jones
The use of amniotic membrane in ophthalmic surgery and other surgical procedures in the fields of dermatology, plastic surgery, genitourinary medicine and otolaryngology is on the increase. Furthermore, amniotic membrane and its epithelial and mesenchymal cells have broad use in regenerative medicine and hold great promise in anticancer treatment. Amniotic membrane is a rich source of biologically active factors and as such, promotes healing and acts as an effective material for wound dressing. Amniotic membrane supports epithelialization and exhibits anti-fibrotic, anti-inflammatory, anti-angiogenic and anti-microbial features...
March 2, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28254417/retrospective-analysis-of-37-287-observation-years-after-peripheral-blood-stem-cell-donation
#3
Alexander H Schmidt, Thilo Mengling, Camila J Hernández-Frederick, Gabi Rall, Julia Pingel, Johannes Schetelig, Gerhard Ehninger
Donor safety is of utmost importance in the setting of hematopoietic stem cell donation. Follow-up is indicated to detect potential long-term risks for donors. We sent a follow-up questionnaire to 15,445 donors of peripheral blood stem cells (PBSCs) or bone marrow (BM) within a retrospective study design. The return rate was 91.3%, resulting in 37,287 observation years for PBSC donors and 25,656 for BM donors. Most donors assessed their health conditions as very good or good and had not been hospitalized or received long-term medical treatment including prescribed medication for more than 4 weeks since donation...
February 22, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28229427/stem-cell-exosomes-cell-freetherapy-for-organ-repair
#4
Mohsin Khan, Raj Kishore
Cardiovascular disease is a significant cause of morbidity and mortality around the world. The damaged cardiac tissue is unable to repair itself following injury warranting the development of alternate therapies. Cell therapy has emerged recently as a viable treatment option resulting in significant improvement in cardiac function. Nevertheless, donated stem cells are hard to find in the heart after transplantation leading to the hypothesis that release of extracellular factors by stem cells is primarily responsible for the beneficial effect of cell therapy...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28144956/cost-effectiveness-of-the-screening-of-blood-donations-for-hepatitis-e-virus-in-the-netherlands
#5
Anneke S de Vos, Mart P Janssen, Hans L Zaaijer, Boris M Hogema
BACKGROUND: The incidence of hepatitis E virus (HEV) has increased substantially in Europe recently, thereby threatening blood safety. A cost-effectiveness analysis for HEV screening of blood donations in the Netherlands was performed. STUDY DESIGN AND METHODS: A simulation model was developed to mimic the process of donation, infections in the donor population, donation testing, and transmission to transfusion recipients. The variability of viral loads among donors was modeled using observed loads...
January 31, 2017: Transfusion
https://www.readbyqxmd.com/read/28140685/interprofessional-spanning-and-building-boundaries-when-supporting-potential-embryo-donors-to-stem-cell-research
#6
Laura L Machin, R A Williams
When patients undergo fertility treatment, it is likely that a surplus of embryos will be created. The existence of these surplus embryos creates responsibilities for the clinics where they are stored and for the people who own them. Since 2001, the owners of the surplus embryos in the UK have the option to donate them to be used in stem cell research (SCR). This development has generated a new population-potential embryo donors to SCR-who have unique support needs as they are neither fertility patients nor donors...
January 31, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28111924/awareness-of-cord-blood-collection-and-the-impact-on-banking
#7
Rusha Bhandari, Amy Lindley, Deepika Bhatla, Aleksandar Babic, Kathy Mueckl, Rakesh Rao, Paula Brooks, Vicki Geiler, Gilad Gross, Mohamad Al-Hosni, Shalini Shenoy
BACKGROUND: Umbilical cord blood (UCB) is an important source of hematopoietic stem cells for transplantation especially in minority populations with limited chances of finding a histocompatible volunteer donor in the registry. UCB has the advantages of early availability, successful outcomes despite some histocompatibility mismatch, and low incidence of chronic graft-versus-host disease. Public cord blood banks that disseminate UCB products for transplant depend on voluntary donation at participating hospitals and obstetrical providers for collection...
January 23, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28049490/mobilization-of-hematopoietic-stem-cells-with-the-novel-cxcr4-antagonist-pol6326-balixafortide-in-healthy-volunteers-results-of-a-dose-escalation-trial
#8
Darja Karpova, Susanne Bräuninger, Eliza Wiercinska, Ariane Krämer, Belinda Stock, Jochen Graff, Hans Martin, Achim Wach, Christophe Escot, Garry Douglas, Barbara Romagnoli, Eric Chevalier, Klaus Dembowski, Leon Hooftman, Halvard Bonig
BACKGROUND: Certain disadvantages of the standard hematopoietic stem and progenitor cell (HSPC) mobilizing agent G-CSF fuel the quest for alternatives. We herein report results of a Phase I dose escalation trial comparing mobilization with a peptidic CXCR4 antagonist POL6326 (balixafortide) vs. G-CSF. METHODS: Healthy male volunteer donors with a documented average mobilization response to G-CSF received, following ≥6 weeks wash-out, a 1-2 h infusion of 500-2500 µg/kg of balixafortide...
January 3, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27959920/evaluation-of-stem-cell-derived-red-blood-cells-as-a-transfusion-product-using-a-novel-animal-model
#9
Sandeep N Shah, Monique P Gelderman, Emily M A Lewis, John Farrel, Francine Wood, Michael Brad Strader, Abdu I Alayash, Jaroslav G Vostal
Reliance on volunteer blood donors can lead to transfusion product shortages, and current liquid storage of red blood cells (RBCs) is associated with biochemical changes over time, known as 'the storage lesion'. Thus, there is a need for alternative sources of transfusable RBCs to supplement conventional blood donations. Extracorporeal production of stem cell-derived RBCs (stemRBCs) is a potential and yet untapped source of fresh, transfusable RBCs. A number of groups have attempted RBC differentiation from CD34+ cells...
2016: PloS One
https://www.readbyqxmd.com/read/27934598/human-embryonic-stem-cells-derived-from-abnormal-blastocyst-donated-by-polycystic-kidney-syndrome-patient
#10
Qi Ouyang, Xiaoying Zhou, Jing Chen, Juan Du, Guangxiu Lu, Ge Lin, Yi Sun
Human embryonic stem cell (hESC) line chHES-468 was derived from abnormal blastocyst donated by polycystic kidney syndrome (PKD) patient after preimplantation genetic diagnosis (PGD) treatment. DNA sequencing analysis confirmed that chHES-468 cell line carried a heterozygous mutation, c.10526_10527delAG, of PKD1. Characteristic tests proved that the chHES-468 cell line presented typical markers of pluripotency and had the capability to form the three germ layers both in vitro and in vivo.
November 5, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27934588/generation-of-human-embryonic-stem-cell-line-chhes-472-from-abnormal-embryos-diagnosed-with-spinocerebellar-ataxia-type-3
#11
Lvjun Liu, Sicong Zeng, Yi Sun, Xiaoying Zhou, Jing Chen, Juan Du, Guangxiu Lu, Ge Lin, Qi Ouyang
Spinocerebellar ataxia type3 (SCA3) is an autosomal dominant neurodegenerative disorder. Human embryonic stem cell line chHES-472 was derived from abnormal embryo donated by SCA3 patient after preimplantation genetic diagnosis (PGD) treatment. This cell line had a normal karyotype and retained the disease-causing mutant in ATXN3 gene. Characteristic tests proved that the embryonic stem cell line presented typical markers of pluripotency and had the capability to form the three germlayers in vivo.
October 24, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27926545/immune-responses-to-bioengineered-organs
#12
Jordi Ochando, Dominique Charron, Pedro M Baptista, Basak E Uygun
PURPOSE OF REVIEW: Organ donation in the United States registered 9079 deceased organ donors in 2015. This high percentage of donations allowed organ transplantation in 29 851 recipients. Despite increasing numbers of transplants performed in comparison with previous years, the numbers of patients that are in need for a transplant increase every year at a higher rate. This reveals that the discrepancy between the demand and availability of organs remains fundamental problem in organ transplantation...
February 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/27922202/current-practices-for-screening-consent-and-care-of-related-donors-in-france-haematopoietic-stem-cell-transplantation-coordinator-nurses-perceptions
#13
A Polomeni, C Bompoint, A Gomez, E Brissot, A Ruggeri, R Belhocine, M Mohty
Haematopoietic stem cell transplantation-coordinating nurses (HSCT-CNs) play an important role in informing related donors (RDs) and in organising human leucocyte antigen (HLA) tests, pre-donation workup and stem cells collection. Our pilot study aimed to explore French HSCT-CNs' perceptions of RD care issues. Twenty-nine French HSCT adult units were sent a questionnaire on the subject of donation procedures, HSCT-CNs' data and their professional experience of related donation issues. Twenty-two HSCT-CNs returned a completed questionnaire, and 90% of HSCT units were involved to some degree in both patient and donor care...
December 6, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27920196/regulation-of-turkey-myogenic-satellite-cell-migration-by-micrornas-mir-128-and-mir-24
#14
S G Velleman, R L Harding
Myogenic satellite cells are an adult stem cell responsible for all post-hatch muscle growth in poultry. As a stem cell population, satellite cells are highly heterogeneous, but the origin of this heterogeneity remains unclear. Heterogeneity is, in part, regulated by gene expression. One method of endogenous gene regulation that may contribute to heterogeneity is microRNAs (miRNAs). Two miRNAs previously shown to regulate poultry myogenic satellite cell proliferation and differentiation, miR-128 and miR-24, were studied to determine if they also affected satellite cell migration...
December 5, 2016: Poultry Science
https://www.readbyqxmd.com/read/27831562/mitochondrial-transfer-of-mesenchymal-stem-cells-effectively-protects-corneal-epithelial-cells-from-mitochondrial-damage
#15
Dan Jiang, Fei Gao, Yuelin Zhang, David Sai Hung Wong, Qing Li, Hung-Fat Tse, Goufeng Xu, Zhendong Yu, Qizhou Lian
Recent studies have demonstrated that mesenchymal stem cells (MSCs) can donate mitochondria to airway epithelial cells and rescue mitochondrial damage in lung injury. We sought to determine whether MSCs could donate mitochondria and protect against oxidative stress-induced mitochondrial dysfunction in the cornea. Co-culturing of MSCs and corneal epithelial cells (CECs) indicated that the efficiency of mitochondrial transfer from MSCs to CECs was enhanced by Rotenone (Rot)-induced oxidative stress. The efficient mitochondrial transfer was associated with increased formation of tunneling nanotubes (TNTs) between MSCs and CECs, tubular connections that allowed direct intercellular communication...
November 10, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27819689/predictors-of-general-discomfort-limitations-in-activities-of-daily-living-and-intention-of-a-second-donation-in-unrelated-hematopoietic-stem-cell-donation
#16
M H Lee, J H Jang, H J Min, H I Jang, J H Nah, C J Lyu, K-S Han, J H Won, Y-H Lee, S Y Chong, Y C Mun, W S Lee, S J Kim, I Kim
We performed a retrospective study of 1868 consecutive unrelated donors to predict the risk factors related to general discomfort, limitations in activities of daily living (ADLs) and intention of a second donation in hematopoietic stem cell (HSC) donation. General discomfort and limitations in ADLs were assessed by numerical measurement (scores of 0-10) and donor's intention of a second donation by yes or no reply. The post-donation questionnaires were completed within 48 h after HSC collection and at 1 week, 4 weeks, and 4 months thereafter...
February 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27813281/factors-associated-with-bone-marrow-stem-cell-yield-for-pediatric-allogeneic-stem-cell-transplantation-the-impact-of-donor-characteristics
#17
Ali Fettah, Namık Özbek, Meltem Özgüner, Fatih Azık, Pamir Işık, Zekai Avcı, Neşe Yaralı, Duygu Uçkan, Bahattin Tunç
The aim of this study was to investigate the effects of donor characteristics on CD34(+) cell yield in BM harvest. Between April 2010 and November 2013, consecutive donors who underwent BM harvesting in our BM transplantation unit were retrospectively investigated. Donors were classified into two groups: those who donated BM without mobilization (steady-state BM donors) and those who received G-CSF for stem cell mobilization (G-CSF-primed BM donors). Donor characteristics (age, gender, race, body weight, BMI, and laboratory factors including donor's leukocyte, platelet, and monocyte) and their relationship with total nuclear cell and CD34(+) cell numbers has been evaluated...
February 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/27796637/how-to-make-insulin-producing-pancreatic-%C3%AE-cells-for-diabetes-treatment
#18
REVIEW
Jiaqi Lu, Qing Xia, Qiao Zhou
Around 400 million people worldwide suffer from diabetes mellitus. The major pathological event for Type 1 diabetes and advanced Type 2 diabetes is loss or impairment of insulin-secreting β cells of the pancreas. For the past 100 years, daily insulin injection has served as a life-saving treatment for these patients. However, insulin injection often cannot achieve full glucose control, and over time poor glucose control leads to severe complications and mortality. As an alternative treatment, islet transplantation has been demonstrated to effectively maintain glucose homeostasis in diabetic patients, but its wide application is limited by the scarcity of donated islets...
October 27, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27788674/mesenchymal-stem-cells-improve-mouse-non-heart-beating-liver-graft-survival-by-inhibiting-kupffer-cell-apoptosis-via-tlr4-erk1-2-fas-fasl-caspase3-pathway-regulation
#19
Yang Tian, Jingcheng Wang, Wei Wang, Yuan Ding, Zhongquan Sun, Qiyi Zhang, Yan Wang, Haiyang Xie, Sheng Yan, Shusen Zheng
BACKGROUND: Liver transplantation is the optimal treatment option for end-stage liver disease, but organ shortages dramatically restrict its application. Donation after cardiac death (DCD) is an alternative approach that may expand the donor pool, but it faces challenges such as graft dysfunction, early graft loss, and cholangiopathy. Moreover, DCD liver grafts are no longer eligible for transplantation after their warm ischaemic time exceeds 30 min. Mesenchymal stem cells (MSCs) have been proposed as a promising therapy for treatment of certain liver diseases, but the role of MSCs in DCD liver graft function remains elusive...
October 27, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27757184/prevalence-of-syphilis-among-blood-and-stem-cell-donors-in-saudi-arabia-an-institutional-experience
#20
Ghaleb Elyamany, Mohamed Al Amro, Winston Costa Pereira, Omar Alsuhaibani
INTRODUCTION: Syphilis is one of the known transfusion-transmissible infections and causes 100,000 deaths yearly, with around 90% of these deaths occurring in the developing world. Little data is available regarding the prevalence of syphilis among Saudi blood and stem cell donors. We conducted a survey on the incidence of syphilis among all blood and stem cell donors. METHODS: This study was conducted at the Prince Sultan Military Medical City in Riyadh, Saudi Arabia in the 10 years period data during 2006-2015...
August 2016: Electronic Physician
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