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Stem cell donation

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https://www.readbyqxmd.com/read/27926545/immune-responses-to-bioengineered-organs
#1
Jordi Ochando, Dominique Charron, Pedro M Baptista, Basak E Uygun
PURPOSE OF REVIEW: Organ donation in the United States registered 9079 deceased organ donors in 2015. This high percentage of donations allowed organ transplantation in 29 851 recipients. Despite increasing numbers of transplants performed in comparison with previous years, the numbers of patients that are in need for a transplant increase every year at a higher rate. This reveals that the discrepancy between the demand and availability of organs remains fundamental problem in organ transplantation...
December 6, 2016: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/27922202/current-practices-for-screening-consent-and-care-of-related-donors-in-france-haematopoietic-stem-cell-transplantation-coordinator-nurses-perceptions
#2
A Polomeni, C Bompoint, A Gomez, E Brissot, A Ruggeri, R Belhocine, M Mohty
Haematopoietic stem cell transplantation-coordinating nurses (HSCT-CNs) play an important role in informing related donors (RDs) and in organising human leucocyte antigen (HLA) tests, pre-donation workup and stem cells collection. Our pilot study aimed to explore French HSCT-CNs' perceptions of RD care issues. Twenty-nine French HSCT adult units were sent a questionnaire on the subject of donation procedures, HSCT-CNs' data and their professional experience of related donation issues. Twenty-two HSCT-CNs returned a completed questionnaire, and 90% of HSCT units were involved to some degree in both patient and donor care...
December 6, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27920196/regulation-of-turkey-myogenic-satellite-cell-migration-by-micrornas-mir-128-and-mir-24
#3
S G Velleman, R L Harding
Myogenic satellite cells are an adult stem cell responsible for all post-hatch muscle growth in poultry. As a stem cell population, satellite cells are highly heterogeneous, but the origin of this heterogeneity remains unclear. Heterogeneity is, in part, regulated by gene expression. One method of endogenous gene regulation that may contribute to heterogeneity is microRNAs (miRNAs). Two miRNAs previously shown to regulate poultry myogenic satellite cell proliferation and differentiation, miR-128 and miR-24, were studied to determine if they also affected satellite cell migration...
December 5, 2016: Poultry Science
https://www.readbyqxmd.com/read/27831562/mitochondrial-transfer-of-mesenchymal-stem-cells-effectively-protects-corneal-epithelial-cells-from-mitochondrial-damage
#4
Dan Jiang, Fei Gao, Yuelin Zhang, David Sai Hung Wong, Qing Li, Hung-Fat Tse, Goufeng Xu, Zhendong Yu, Qizhou Lian
Recent studies have demonstrated that mesenchymal stem cells (MSCs) can donate mitochondria to airway epithelial cells and rescue mitochondrial damage in lung injury. We sought to determine whether MSCs could donate mitochondria and protect against oxidative stress-induced mitochondrial dysfunction in the cornea. Co-culturing of MSCs and corneal epithelial cells (CECs) indicated that the efficiency of mitochondrial transfer from MSCs to CECs was enhanced by Rotenone (Rot)-induced oxidative stress. The efficient mitochondrial transfer was associated with increased formation of tunneling nanotubes (TNTs) between MSCs and CECs, tubular connections that allowed direct intercellular communication...
November 10, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27819689/predictors-of-general-discomfort-limitations-in-activities-of-daily-living-and-intention-of-a-second-donation-in-unrelated-hematopoietic-stem-cell-donation
#5
M H Lee, J H Jang, H J Min, H I Jang, J H Nah, C J Lyu, K-S Han, J H Won, Y-H Lee, S Y Chong, Y C Mun, W S Lee, S J Kim, I Kim
We performed a retrospective study of 1868 consecutive unrelated donors to predict the risk factors related to general discomfort, limitations in activities of daily living (ADLs) and intention of a second donation in hematopoietic stem cell (HSC) donation. General discomfort and limitations in ADLs were assessed by numerical measurement (scores of 0-10) and donor's intention of a second donation by yes or no reply. The post-donation questionnaires were completed within 48 h after HSC collection and at 1 week, 4 weeks, and 4 months thereafter...
November 7, 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27813281/factors-associated-with-bone-marrow-stem-cell-yield-for-pediatric-allogeneic-stem-cell-transplantation-the-impact-of-donor-characteristics
#6
Ali Fettah, Namık Özbek, Meltem Özgüner, Fatih Azık, Pamir Işık, Zekai Avcı, Neşe Yaralı, Duygu Uçkan, Bahattin Tunç
The aim of this study was to investigate the effects of donor characteristics on CD34(+) cell yield in BM harvest. Between April 2010 and November 2013, consecutive donors who underwent BM harvesting in our BM transplantation unit were retrospectively investigated. Donors were classified into two groups: those who donated BM without mobilization (steady-state BM donors) and those who received G-CSF for stem cell mobilization (G-CSF-primed BM donors). Donor characteristics (age, gender, race, body weight, BMI, and laboratory factors including donor's leukocyte, platelet, and monocyte) and their relationship with total nuclear cell and CD34(+) cell numbers has been evaluated...
November 4, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27796637/how-to-make-insulin-producing-pancreatic-%C3%AE-cells-for-diabetes-treatment
#7
REVIEW
Jiaqi Lu, Qing Xia, Qiao Zhou
Around 400 million people worldwide suffer from diabetes mellitus. The major pathological event for Type 1 diabetes and advanced Type 2 diabetes is loss or impairment of insulin-secreting β cells of the pancreas. For the past 100 years, daily insulin injection has served as a life-saving treatment for these patients. However, insulin injection often cannot achieve full glucose control, and over time poor glucose control leads to severe complications and mortality. As an alternative treatment, islet transplantation has been demonstrated to effectively maintain glucose homeostasis in diabetic patients, but its wide application is limited by the scarcity of donated islets...
October 27, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27788674/mesenchymal-stem-cells-improve-mouse-non-heart-beating-liver-graft-survival-by-inhibiting-kupffer-cell-apoptosis-via-tlr4-erk1-2-fas-fasl-caspase3-pathway-regulation
#8
Yang Tian, Jingcheng Wang, Wei Wang, Yuan Ding, Zhongquan Sun, Qiyi Zhang, Yan Wang, Haiyang Xie, Sheng Yan, Shusen Zheng
BACKGROUND: Liver transplantation is the optimal treatment option for end-stage liver disease, but organ shortages dramatically restrict its application. Donation after cardiac death (DCD) is an alternative approach that may expand the donor pool, but it faces challenges such as graft dysfunction, early graft loss, and cholangiopathy. Moreover, DCD liver grafts are no longer eligible for transplantation after their warm ischaemic time exceeds 30 min. Mesenchymal stem cells (MSCs) have been proposed as a promising therapy for treatment of certain liver diseases, but the role of MSCs in DCD liver graft function remains elusive...
October 27, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27757184/prevalence-of-syphilis-among-blood-and-stem-cell-donors-in-saudi-arabia-an-institutional-experience
#9
Ghaleb Elyamany, Mohamed Al Amro, Winston Costa Pereira, Omar Alsuhaibani
INTRODUCTION: Syphilis is one of the known transfusion-transmissible infections and causes 100,000 deaths yearly, with around 90% of these deaths occurring in the developing world. Little data is available regarding the prevalence of syphilis among Saudi blood and stem cell donors. We conducted a survey on the incidence of syphilis among all blood and stem cell donors. METHODS: This study was conducted at the Prince Sultan Military Medical City in Riyadh, Saudi Arabia in the 10 years period data during 2006-2015...
August 2016: Electronic Physician
https://www.readbyqxmd.com/read/27751935/health-related-quality-of-life-among-older-related-hematopoietic-stem-cell-donors-60-years-is-equivalent-to-that-of-younger-related-donors-18-to-60-years-a-related-donor-safety-study
#10
Galen E Switzer, Jessica Bruce, Deidre M Kiefer, Hati Kobusingye, Rebecca Drexler, RaeAnne M Besser, Dennis L Confer, Mary M Horowitz, Roberta J King, Bronwen E Shaw, Marcie Riches, Brandon Hayes-Lattin, Michael Linenberger, Brian Bolwell, Scott D Rowley, Mark R Litzow, Michael A Pulsipher
The increasing number of older adults with blood-related disorders and the introduction of reduced-intensity conditioning regimens has led to increases in hematopoietic stem cell (HSC) transplantation among older adults and a corresponding increase in the age of siblings who donate HSCs to these patients. Data regarding the donation-related experiences of older donors are lacking. The Related Donor Safety Study aimed to examine/compare health-related quality of life (HRQoL) of older versus younger HSC donors...
October 14, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27665155/factors-affecting-the-cd34-cell-yields-from-the-second-donations-of-healthy-donors-the-steady-state-lymphocyte-count-is-a-good-predictive-factor
#11
Zhi-Ping Guo, Tao Wang, Lan-Ping Xu, Xiao-Hui Zhang, Yu Wang, Xiao-Jun Huang, Ying-Jun Chang
BACKGROUND: A second allogeneic hematopoietic stem-cell transplantation and donor lymphocyte infusion using cells from the same donor is a therapeutic option in the case of stem-cell graft failure or disease relapse, but little is known about the factors associated with the CD34(+) cell yields from second donations. METHODS: One-hundred healthy donors who underwent a second mobilization treatment and peripheral blood stem-cell (PBSC) collection were studied. For both mobilization processes, 5 µg of granulocyte colony-stimulating factor per kg per day was administered...
August 26, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/27657022/comparison-of-the-antioxidant-effects-of-quercitrin-and-isoquercitrin-understanding-the-role-of-the-6%C3%A2-oh-group
#12
Xican Li, Qian Jiang, Tingting Wang, Jingjing Liu, Dongfeng Chen
The role of the 6″-OH (ω-OH) group in the antioxidant activity of flavonoid glycosides has been largely overlooked. Herein, we selected quercitrin (quercetin-3-O-rhamnoside) and isoquercitrin (quercetin-3-O-glucoside) as model compounds to investigate the role of the 6″-OH group in several antioxidant pathways, including Fe(2+)-binding, hydrogen-donating (H-donating), and electron-transfer (ET). The results revealed that quercitrin and isoquercitrin both exhibited dose-dependent antioxidant activities...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27641650/ipsc-mscs-with-high-intrinsic-miro1-and-sensitivity-to-tnf-%C3%AE-yield-efficacious-mitochondrial-transfer-to-rescue-anthracycline-induced-cardiomyopathy
#13
Yuelin Zhang, Zhendong Yu, Dan Jiang, Xiaoting Liang, Songyan Liao, Zhao Zhang, Wensheng Yue, Xiang Li, Sin-Ming Chiu, Yuet-Hung Chai, Yingmin Liang, Yenyen Chow, Shuo Han, Aimin Xu, Hung-Fat Tse, Qizhou Lian
Mesenchymal stem cells (MSCs) can donate mitochondria and rescue anthracycline-induced cardiomyocyte (CM) damage, although the underlying mechanisms remain elusive. We determined that the superior efficiency of mitochondrial transfer by human induced-pluripotent-stem-cell-derived MSCs (iPSC-MSCs) compared with bone marrow-derived MSCs (BM-MSCs) is due to high expression of intrinsic Rho GTPase 1 (MIRO1). Further, due to a higher level of TNFαIP2 expression, iPSC-MSCs are more responsive to tumor necrosis factor alpha (TNF-α)-induced tunneling nanotube (TNT) formation for mitochondrial transfer to CMs, which is regulated via the TNF-α/NF-κB/TNFαIP2 signaling pathway...
October 11, 2016: Stem Cell Reports
https://www.readbyqxmd.com/read/27558602/derivation-of-the-clinical-grade-human-embryonic-stem-cell-line-rce015-a-rc-11
#14
P A De Sousa, B J Tye, K Bruce, P Dand, G Russell, D M Collins, A Greenshields, K McDonald, H Bradburn, A Laurie, M Canham, T Kunath, J M Downie, M Bateman, A Courtney
The human embryonic stem cell line RCe015-A (RC-11) was derived under quality assured compliance with UK regulation, European Union Directives and International guidance for tissue procurement, processing and storage according to Good Manufacturing Practice (GMP) standards. The cell line was derived from a fragmented cleavage stage embryo voluntarily donated as unsuitable or surplus to fertility requirements following informed consent. RCe015-A (RC-11) shows normal pluripotency marker expression and differentiation to the three germ layers in vitro and in vivo...
May 7, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27558601/derivation-of-the-clinical-grade-human-embryonic-stem-cell-line-rce013-a-rc-9
#15
P A De Sousa, B J Tye, K Bruce, P Dand, G Russell, D M Collins, A Greenshields, K McDonald, H Bradburn, M A Canham, T Kunath, J M Downie, M Bateman, A Courtney
The human embryonic stem cell line RCe013-A (RC-9) was derived under quality assured compliance with UK regulation, European Union Directives and International guidance for tissue procurement, processing and storage according to Good Manufacturing Practice (GMP) standards. The cell line was derived from a failed to fertilise oocyte voluntarily donated as unsuitable and surplus to fertility requirements following informed consent. RCe013-A (RC-9) shows normal pluripotency marker expression and differentiation to the three germ layers in vitro and in vivo...
May 6, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27558596/derivation-of-the-clinical-grade-human-embryonic-stem-cell-line-rce021-a-rc-17
#16
P A De Sousa, B J Tye, K Bruce, P Dand, G Russell, D M Collins, A Greenshields, K McDonald, H Bradburn, D Allan, A Laurie, T Kunath, M A Canham, J M Downie, M Bateman, A Courtney
The human embryonic stem cell line RCe021-A (RC-17) was derived under quality assured compliance with UK regulation, European Union Directives and International guidance for tissue procurement, processing and storage according to Good Manufacturing Practice (GMP) standards. The cell line was derived from a day 3 embryo voluntarily donated as unsuitable or surplus to fertility requirements following informed consent. RCe021-A (RC-17) shows normal pluripotency marker expression and differentiation to the three germ layers in vitro...
April 30, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27543914/qtc-prolongation-during-peripheral-stem-cell-apheresis-in-healthy-volunteers
#17
Aslı Korur, Ilknur Kozanoglu, Nurhilal Buyukkurt, Mahmut Yeral, Fatih Kandemir, Cigdem Gereklioglu, Cagla Sariturk, Suheyl Asma, Soner Solmaz, Can Boga, Hakan Ozdogu
BACKGROUND AND AIM: Today, voluntary donation of peripheral blood stem cells by healthy donors for allogeneic hemopoietic cell transplantation is common worldwide. Such donations are associated with small but measurable risks of morbidity and mortality. Most complications are associated with citrate infusion during cell collection. We studied the effects of citrate infusion on the QTc and other vital parameters during and after peripheral stem cell apheresis in volunteers. METHOD: To ensure that donors were healthy, screening included taking a detailed medical history, physical examination, and laboratory measurements of plasma calcium and magnesium...
August 20, 2016: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/27523468/directed-differentiation-of-human-embryonic-stem-cells-to-corneal-endothelial-cell-like-cells-a-transcriptomic-analysis
#18
Qinglu Song, Songtao Yuan, Qin An, Yinyin Chen, Frank Fuxiang Mao, Yizhi Liu, Qinghuai Liu, Guoping Fan
Corneal endothelial cells (CECs) are a monolayer of cells covering the inner-side of cornea, playing a pivotal role in keeping the cornea transparent. Because adult CECs have no proliferative capacity, the loss of CECs during aging or under pathological conditions would lead to corneal edema, eventually leading to the blindness. Clinically, donated CECs have been successfully transplanted to treat the diseases of CEC deficiency; however, the source of CEC donation is very limited. As an alternative cell source for CEC transplantation, CEC-like cells can be obtained via in vitro differentiation of human pluripotent stem cells...
October 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27522440/health-related-quality-of-life-among-pediatric-hematopoietic-stem-cell-donors
#19
Galen E Switzer, Jessica Bruce, Deidre M Kiefer, Hati Kobusingye, Rebecca Drexler, RaeAnne M Besser, Dennis L Confer, Mary M Horowitz, Roberta J King, Bronwen E Shaw, Suzanna M van Walraven, Lori Wiener, Wendy Packman, James W Varni, Michael A Pulsipher
OBJECTIVES: To examine health-related quality of life (HRQoL) among sibling pediatric hematopoietic stem cell donors from predonation through 1 year postdonation, to compare donor-reported HRQoL scores with proxy-reports by parents/guardians and those of healthy norms, and to identify predonation factors (including donor age) potentially associated with postdonation HRQoL, to better understand the physical and psychosocial effects of pediatric hematopoietic stem cell donation. STUDY DESIGN: A random sample of 105 pediatric donors from US centers and a parent/guardian were interviewed by telephone predonation and 4 weeks and 1 year postdonation...
November 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27500950/sixty-as-the-new-forty-considerations-on-older-related-stem-cell-donors
#20
P Anderlini
The era of reduced-intensity allogeneic stem cell transplantation, with its emphasis on older patients, has created new challenges in the management of what is now an older related stem cell donor population. These donors are now on average no less than 10 years older than in the mid-1990s. Donors over 70 years of age are no longer isolated or exceptional cases. They may still be considered eligible for donation but many of them, based on the older age and their medical history, may no longer fully qualify as 'healthy' or 'normal'...
August 8, 2016: Bone Marrow Transplantation
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