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Ammad Ahmad Farooqi, Qaisar Mansoor, Nada Alaaeddine, Baojun Xu
Substantial fraction of high-quality information is continuously being added into the existing pool of knowledge related to the biology of telomeres. Based on the insights gleaned from decades of research, it is clear that chromosomal stability needs a highly controlled and dynamic balance of DNA gain and loss in each terminal tract of telomeric repeats. Telomeres are formed by tandem repeats of TTAGGG sequences, which are gradually lost with each round of division of the cells. Targeted inhibition of telomerase to effectively induce apoptosis in cancer cells has attracted tremendous attention and overwhelmingly increasingly list of telomerase inhibitors truthfully advocates pharmacological significance of telomerase...
April 1, 2018: International Journal of Molecular Sciences
Shuai Xu, Arthur Papier
No abstract text is available yet for this article.
February 7, 2018: American Journal of Medicine
Irina Papier, Jesse Lachter, Gila Hyams, Irit Chermesh
BACKGROUND & AIMS: Nurses have crucial roles in optimizing nutritional therapy for patients. The aim of this study was to explore nurses' perceptions regarding barriers to effective nutritional therapy. METHODS: Hospital-based nurses completed a questionnaire regarding various aspects of malnutrition/risk identification and barriers to effective nutritional treatment. The study was conducted at Rambam Health Care Campus with 100 nurses completing the questionnaire...
December 2017: Clinical Nutrition ESPEN
Keren Papier, Susan Jordan, Catherine D'Este, Cathy Banwell, Vasoontara Yiengprugsawan, Sam-Ang Seubsman, Adrian Sleigh
In recent decades, a health-risk transition with changes in diet and lifestyle in low and middle-income countries (LMICs) led to an emergence of chronic diseases. These trends in Southeast Asian LMICs are not well studied. Here, we report on transitional dietary patterns and their socio-demographic predictors in Thai adults. Dietary data in 2015 were from a random sub-sample ( N = 1075) of 42,785 Thai Cohort Study (TCS) members who completed all three TCS surveys (2005, 2009, 2013). Principle Component Analysis identified dietary patterns and multivariable linear regression assessed associations (Beta estimates (ß) and confidence intervals (CIs)) between socio-demographic factors and dietary intake pattern scores...
October 27, 2017: Nutrients
Keren Papier, Catherine D'Este, Chris Bain, Cathy Banwell, Sam-Ang Seubsman, Adrian Sleigh, Susan Jordan
BACKGROUND: Body mass index (BMI) cut-off values (>25 and >30) that predict diabetes risk have been well validated in Caucasian populations but less so in Asian populations. We aimed to determine the BMI threshold associated with increased type 2 diabetes (T2DM) risk and to calculate the proportion of T2DM cases attributable to overweight and obesity in the Thai population. METHODS: Participants were those from the Thai Cohort Study who were diabetes-free in 2005 and were followed-up in 2009 and 2013 (n = 39,021)...
September 15, 2017: BMC Public Health
Vasoontara Yiengprugsawan, Wimalin Rimpeekool, Keren Papier, Cathy Banwell, Sam-Ang Seubsman, Adrian C Sleigh
BACKGROUND: Overweight and obesity have been shown to be risk factors for a range of non-communicable diseases, especially cardio-metabolic conditions, worldwide. But less is known about the effects of weight change on adults' overall health and wellbeing, particularly in transitional low- and middle-income countries. This study aimed to assess the relationship between 8-year weight change and measures of self-assessed health among Thai adults. METHODS: Data were collected from Thai adults aged 25-40 years (n = 27,003) enrolled in the Thai cohort Study and surveyed in 2005, 2009, and 2013...
October 2017: Journal of Epidemiology
K Papier, C D'Este, C Bain, C Banwell, S Seubsman, A Sleigh, S Jordan
BACKGROUND: The global prevalence of type 2 diabetes mellitus (T2DM) is high and is increasing in countries undergoing rapid socio-economic development, including Thailand. Sugar-sweetened beverage (SSB) intake may contribute to the risk of developing T2DM. However, few studies have assessed this association in Asian populations, and the results have been inconsistent. We aimed to assess that association in a prospective study of Thai adults. METHODS: Data were from Thai Cohort Study participants surveyed in 2005, 2009 and 2013...
June 19, 2017: Nutrition & Diabetes
Keren Papier, Susan Jordan, Catherine D'Este, Chris Bain, Janya Peungson, Cathy Banwell, Vasoontara Yiengprugsawan, Sam-Ang Seubsman, Adrian Sleigh
BACKGROUND: Type 2 diabetes mellitus (T2DM) is increasingly prevalent in countries undergoing rapid development, including Thailand. We assessed T2DM incidence over an 8-year period in a nationwide cohort of Thai adults. METHODS: Thai Cohort Study participants were surveyed in 2005, 2009 and 2013. The analysed cohort members were aged (15-88), did not have diabetes in 2005 and were followed up by questionnaire in 2013 (n=39 507). T2DM was ascertained using self-report, which has been validated using physician interviews...
December 13, 2016: BMJ Open
Collin R Diedrich, Jennifer O'Hern, Maximiliano G Gutierrez, Nafiesa Allie, Patricia Papier, Graeme Meintjes, Anna K Coussens, Helen Wainwright, Robert J Wilkinson
BACKGROUND:  Human immunodeficiency virus type 1 (HIV)-infected persons are more susceptible to tuberculosis than HIV-uninfected persons. Low peripheral CD4(+) T-cell count is not the sole cause of higher susceptibility, because HIV-infected persons with a high peripheral CD4(+) T-cell count and those prescribed successful antiretroviral therapy (ART) remain more prone to active tuberculosis than HIV-uninfected persons. We hypothesized that the increase in susceptibility is caused by the ability of HIV to manipulate Mycobacterium tuberculosis-associated granulomas...
November 1, 2016: Journal of Infectious Diseases
Patricia Carrascosa, Carlos Capuñay, Javier Vallejos, Jimena Carpio, Mariano Baronio, Sergio Papier
Noninvasive imaging techniques play an important role in the female infertility diagnostic algorithm. In this review article, a description of the diagnostic performance and potential clinical value of both computerized tomographic virtual hysterosalpingography (CT-VHGS) and magnetic-resonance virtual hysterosalpingography (MR-VHSG) is made, describing for both techniques, to guarantee the best possible diagnostic outcome, patient preparation and normal and principal pathologic findings. Both noninvasive diagnostic imaging modalities improve the diagnostic confidence in identification of the specific cause of female infertility...
June 2016: Fertility and Sterility
Zygmunt Zdrojewicz, Radosław Konieczny, Paulina Papier, Filip Szten
Compared to efficient and secure female contraception, a vasectomy and condoms are the only options for men. The choice of male contraceptive methods is limited, so contraception mainly rests on the shoulders of women. Several concepts are considered: testosterone administration--inhibiting pituitary secretion of lutropin (LH) and follicle stimulating hormone (FSH), progestogen--affecting the secretion of gonadotropin and gonadoliberin (GnRH) antagonists. New potential targets for non-hormonal male contraception were discovered: glyceraldehyde-3-phosphate-dehydrogenase (GAPDHS)--specific to male germ cells and voltage-gated cation channel (CatSper)...
July 2015: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Marcin Barczyński, Aleksandra Papier, Jakub Kenig, Ireneusz Nawrot
INTRODUCTION: Minimally invasive parathyroidectomy (MIP) with intraoperative parathyroid hormone assay (IOPTH) has successfully replaced conventional neck exploration in most patients with primary hyperparathyroidism (pHPT) and preoperatively localized parathyroid adenoma. AIM: To compare outcomes of video-assisted MIP (MIVAP) to open MIP (OMIP). MATERIAL AND METHODS: A retrospective case-controlled study of 455 patients with sporadic pHPT undergoing MIP with IOPTH at our institution in 2003-2012 was undertaken...
December 2014: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
Keren Papier, Faruk Ahmed, Patricia Lee, Juliet Wiseman
OBJECTIVE: The aim of this study was to examine the relationship between stress and food selection patterns by sex among first-year undergraduate students studying in an Australian university. METHODS: Participating in this cross-sectional study were 728 (331 men and 397 female students) first-year students, ages >18 y, attending the Gold Coast Campus of Griffith University. Data were collected using a self-administered questionnaire consisting of three sections: sociodemographic information, stress measures, and a 7-d food frequency questionnaire...
February 2015: Nutrition
Marta Manso, Ana Bidarra, Stéphane Longelin, Sofia Pessanha, Adriana Ferreira, Mauro Guerra, João Coroado, Luísa Carvalho
The analysis of a Portuguese "papier-mâché" sculpture depicting Saint Anthony is presented in this case study. Several questions were addressed such as the characteristics of the support, pigments used, and artistic technique in order to establish a possible timeline for its production. Qualitative analyses of the cross-sections and of the paper support were performed by optical microscopy using reflected light. Two polychrome layers from different periods and a rag pulped support were identified on the sculpture...
February 2015: Microscopy and Microanalysis
Shawn Somerset, Keren Papier
Flavonoids, a broad category of nonnutrient food components, are potential protective dietary factors in the etiology of some cancers. However, previous epidemiological studies showing associations between flavonoid intake and cancer risk have used unvalidated intake assessment methods. A 62-item food frequency questionnaire (FFQ) based on usual intake of a representative Australian adult population sample was validated against a 3-day diet diary method in 60 young adults. Spearman's rank correlations showed 17 of 25 individual flavonoids, 3 of 5 flavonoid subgroups, and total flavonoids having strong/moderate correlation coefficients (0...
2014: Nutrition and Cancer
Demián Glujovsky, Barbara Riestra, Carlos Sueldo, Gabriel Fiszbajn, Sjoerd Repping, Florencia Nodar, Sergio Papier, Agustín Ciapponi
BACKGROUND: Oocyte cryopreservation is a technique with considerable potential in reproductive medicine, including  fertility preservation, as a way of delaying childbearing and as part of oocyte donation programs. Although the technique was relatively ineffective at first more recently numerous modifications have led to higher success rates. OBJECTIVES: To compare the effectiveness and safety of vitrification and slow freezing as oocyte cryopreservation techniques for fertility outcomes in women undergoing assisted reproduction...
September 5, 2014: Cochrane Database of Systematic Reviews
M E Davis
For many centuries our knowledge of Chinese achievements was limited to natural silk, cloissoné, porcelain, jade, ivory and papier maché. Their philosophy and art of healing remained virtually unknown.
March 1973: Australian Journal of Physiotherapy
Aleksandra Papier, Jakub Kenig, Marcin Barczyński
BACKGROUND AND AIMS: Bilateral neck exploration (BNE) is the preferred surgical technique in patients with primary hyperparathyroidism (pHPT) not eligible for minimally invasive parathyroidectomy (MIP). The aim of this study was to assess indications for BNE in the era of MIP, including short-term outcomes of surgery with intraoperative intact parathyroid hormone (iPTH) monitoring added-value. METHODS: Data of 155 patients with pHPT qualified for BNE with intraoperative iPTH monitoring and treated in 2003-2012 were retrospectively analysed...
2014: Przegla̧d Lekarski
Aleksandra Papier, Jakub Kenig, Marcin Barczyński
INTRODUCTION: Intraoperative iPTH assay (IOPTH) is often used during minimally invasive parathyroidectomy (MIP) to predict operative success. The aim of this study was to evaluate diagnostic accuracy of IOPTH during MIP with respect to few prognostic criteria most commonly used. METHODS: A retrospective study of 455 patients with sporadic primary hyperparathyroidism undergoing MIP with IOPTH at our institution between 2003 and 2012 was undertaken. Diagnostic accuracy of few prognostic criteria most commonly used was done including Halle, Miami, Rome and Vienna criteria...
2014: Przegla̧d Lekarski
Keren Papier, Gail M Williams, Ruby Luceres-Catubig, Faruk Ahmed, Remigio M Olveda, Donald P McManus, Delia Chy, Thao N P Chau, Darren J Gray, Allen G P Ross
BACKGROUND: There is evidence to support that nutritional deficiency can reduce the body's immune function, thereby decreasing resistance to disease and increasing susceptibility to intestinal parasites. METHODS: A cross-sectional survey was carried out on 693 school-aged children from 5 schistosomiasis-endemic villages in Northern Samar, the Philippines. Data on dietary intake, nutritional status, and intestinal parasitic infection were collected. RESULTS: The prevalence of stunting, thinness, and wasting was 49...
July 15, 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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