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https://www.readbyqxmd.com/read/28745582/cyp2c19-guided-antiplatelet-therapy-a-cost-effectiveness-analysis-of-30-day-and-1-year-outcomes-following-percutaneous-coronary-intervention
#1
Mrudula S Borse, Olivia M Dong, Melissa J Polasek, Joel F Farley, George A Stouffer, Craig R Lee
AIM: Determine whether using CYP2C19 genotype to optimize antiplatelet therapy selection is cost effective over the initial 30 days and 1-year following percutaneous coronary intervention. MATERIALS & METHODS: A cost-effectiveness analysis compared 30-day and 1-year outcomes and cost across three treatment strategies (universal clopidogrel, universal prasugrel, genotype-guided) in a hypothetical cohort. RESULTS: Base-case scenario results at 30 days indicated that the incremental cost per major cardiovascular or bleeding event avoided for genotype-guided treatment was US$8525 and US$42,198 compared with universal clopidogrel and prasugrel, respectively...
August 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28655429/a-study-of-the-correlation-between-ultrafine-particle-emissions-in-motorcycle-smoke-and-mice-erythrocyte-damages
#2
Arinto Y P Wardoyo, Unggul P Juswono, Johan A E Noor
Sharply increasing of motor vehicles every year contributes to amounts of ultrafine particles (UFPs) in the air. Besides, the existence of UFPs in the blood may cause erythrocyte damages that subject to shape deformation. This study was aimed to investigate the influence of UFPs in the motorcycle smoke exposed to mice in different concentrations to the erythrocyte damages. The experiments were conducted by injecting the motorcycle smoke with the varied amounts in an experimental chamber (dimension of 30×20×20cm(3)) where the mice were put in advance for exposuring twice a day (100s)...
October 2, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28554251/association-between-circulating-microrna-208a-and-severity-of-coronary-heart-disease
#3
Yao Zhang, Hai-Hong Li, Rui Yang, Bai-Jing Yang, Zhao-Yu Gao
Circulating microRNA (miR)-208a is specifically expressed in the heart muscle, which is involved in the regulation of myosin during cardiac development. Previous studies reported that cardiac-specific miR-208a level is significantly higher in plasma of coronary heart disease (CHD) patients. However, whether it correlates with severity of CHD, has never been elucidated before. The aim of this study was to explore the association between miR-208a and the presence and severity of CHD. Samples were collected from 290 CHD patients and 110 subjects with angiographic exclusion of CHD...
May 30, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28514747/diagnostic-value-of-using-18f-fdg-pet-and-pet-ct-in-immunocompetent-patients-with-primary-central-nervous-system-lymphoma-a-systematic-review-and-meta-analysis
#4
Yaru Zou, Jianjing Tong, Haiyan Leng, Jingwei Jiang, Meng Pan, Zi Chen
BACKGROUND: 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and PET/CT have become two of the most powerful tools for malignant lymphoma exploration, but their diagnostic role in primary central nervous system lymphoma (PCNSL) is still disputed. The purpose of our study is to identify the usefulness of 18F-FDG PET and PET/CT for detecting PCNSL. RESULTS: A total of 129 patients, obtained from eight eligible studies, were included for this systematic review and meta-analysis...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28426545/sex-differences-in-prescription-opioid-use
#5
Mirsada Serdarevic, Catherine W Striley, Linda B Cottler
PURPOSE OF REVIEW: Recent literature focused on prescription opioids has neglected sex differences in use. Here, we evaluated the recent literature (since 2015) examining sex differences in prescription opioid use. RECENT FINDINGS: Between 2015 and 2016, our review found only eight articles addressing sex differences in prescription opioid use mostly opioid misuse in North America among individuals with chronic pain. Risk factors included depression, pain, and polydrug use...
July 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/26907726/growth-temperature-and-genotype-both-play-important-roles-in-sorghum-grain-phenolic-composition
#6
Gangcheng Wu, Stuart K Johnson, Janet F Bornman, Sarita J Bennett, Michael W Clarke, Vijaya Singh, Zhongxiang Fang
Polyphenols in sorghum grains are a source of dietary antioxidants. Polyphenols in six diverse sorghum genotypes grown under two day/night temperature regimes of optimal temperature (OT, 32/21 °C and high temperature (HT, 38/21 °C) were investigated. A total of 23 phenolic compounds were positively or tentatively identified by HPLC-DAD-ESIMS. Compared with other pigmented types, the phenolic profile of white sorghum PI563516 was simpler, since fewer polyphenols were detected. Brown sorghum IS 8525 had the highest levels of caffeic and ferulic acid, but apigenin and luteolin were not detected...
February 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26467676/neutralizing-antibody-and-botulinum-toxin-therapy-a-systematic-review-and-meta-analysis
#7
REVIEW
Margherita Fabbri, Giorgio Leodori, Ricardo M Fernandes, Roongroj Bhidayasiri, Maria Jose Marti, Carlo Colosimo, Joaquim J Ferreira
The formation of neutralizing antibodies (NAbs) directed specifically against the active neurotoxin part of the botulinum neurotoxin (BoNT) complex is often cited as a major cause of secondary non-responsiveness (SnR) to treatment. This systematic and meta-analytic review evaluates the frequency of NAbs among patients treated with BoNT therapy for any clinical indication. A comprehensive database search strategy was designed to retrieve relevant clinical data from the published literature up to April 2013. All English-language publications that analyzed NAbs prevalence in more than ten patients were included, regardless of BoNT formulation, assay method, and study design...
January 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/26150198/exposure-to-and-searching-for-information-about-suicide-and-self-harm-on-the-internet-prevalence-and-predictors-in-a-population-based-cohort-of-young-adults
#8
Becky Mars, Jon Heron, Lucy Biddle, Jenny L Donovan, Rachel Holley, Martyn Piper, John Potokar, Clare Wyllie, David Gunnell
BACKGROUND: There is concern over the potential impact of the Internet on self-harm and suicidal behaviour, particularly in young people. However, little is known about the prevalence and patterns of suicide/self-harm related Internet use in the general population. METHODS: Cross sectional study of 3946 of the 8525 participants in the Avon Longitudinal Study of Parents and Children (ALSPAC) who were sent a self-report questionnaire including questions on suicide/self-harm related Internet use and self-harm history at age 21 years...
October 1, 2015: Journal of Affective Disorders
https://www.readbyqxmd.com/read/25667335/marine-lactobacillus-pentosus-h16-protects-artemia-franciscana-from-vibrio-alginolyticus-pathogenic-effects
#9
M E Garcés, C Sequeiros, N L Olivera
Vibrio alginolyticus is an opportunistic pathogen which may affect different aquatic organisms. The aim of this study was to assess the probiotic properties and the protective mode of action of Lactobacillus pentosus H16 against V. alginolyticus 03/8525, through in vitro and in vivo studies using Artemia franciscana (hereafter Artemia). This strain showed antimicrobial activity against V. alginolyticus 03/8525 and Aeromonas salmonicida subsp. salmonicida ATCC33658 possibly related to lactobacilli organic acid production...
February 10, 2015: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/25284505/annotated-checklist-and-distribution-of-the-lizards-of-iran
#10
Jiří Smíd, Jiří Moravec, Petr Kodym, Lukáš Kratochvíl, Seyyed Saeed Hosseinian Yousefkhani, Daniel Frynta
We present a comprehensive summary of the distribution of the lizards of Iran accompanied by an annotated checklist. The updated maps of distribution of all 146 species of 41 genera of 11 families are based on all available bibliographic records, catalogues of museum collections and our own field observations. The final dataset used for the distribution maps contains 8525 georeferenced records and cover 41% of the country when plotted on a grid of 0.25° × 0.25° resolution. The dataset is publicly accessible through GBIF portal (http://www...
2014: Zootaxa
https://www.readbyqxmd.com/read/24860114/paracoccus-lutimaris-sp-nov-isolated-from-a-tidal-flat-sediment
#11
Yong-Taek Jung, Sooyeon Park, Jung-Sook Lee, Jung-Hoon Yoon
A Gram-negative, coccoid or oval-shaped and gliding bacterial strain, designated HDM-25(T), belonging to the Alphaproteobacteria, was isolated from a tidal flat sediment of the Yellow Sea, Korea, and was subjected to a polyphasic taxonomic study. Strain HDM-25(T) grew optimally at pH 7.0-8.0, at 30 °C and in the presence of 2-3% (w/v) NaCl. Neighbour-joining, maximum-likelihood and maximum-parsimony phylogenetic trees based on 16S rRNA gene sequences showed that strain HDM-25(T) fell within the clade comprising the species of the genus Paracoccus, clustering with the type strain of Paracoccus aminophilus, with which it exhibited the highest 16S rRNA gene sequence similarity (97...
August 2014: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/23016665/combined-crossed-beam-and-theoretical-studies-of-the-n-2d-c2h4-reaction-and-implications-for-atmospheric-models-of-titan
#12
Nadia Balucani, Dimitrios Skouteris, Francesca Leonori, Raffaele Petrucci, Mathias Hamberg, Wolf D Geppert, Piergiorgio Casavecchia, Marzio Rosi
The dynamics of the H displacement channels in the reaction N((2)D) + C(2)H(4) have been investigated by the crossed molecular beam technique with mass spectrometric detection and time-of-flight analysis at two different collision energies (17.2 and 28.2 kJ/mol). The interpretation of the scattering results is assisted by new electronic structure calculations of stationary points and product energetics for the C(2)H(4)N ground state doublet potential energy surface. RRKM statistical calculations have been performed to derive the product branching ratio under the conditions of the present experiments and of the atmosphere of Titan...
November 1, 2012: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/22961813/evaluation-of-incremental-healthcare-resource-burden-and-readmission-rates-associated-with-hospitalized-hyponatremic-patients-in-the-us
#13
Alpesh Amin, Steven Deitelzweig, Rudell Christian, Keith Friend, Jay Lin, Kathy Belk, Dorothy Baumer, Timothy J Lowe
BACKGROUND: Hyponatremia is a prevalent electrolyte disorder in hospitalized patients indicative of greater morbidity and mortality. A large-scale retrospective analysis was conducted to evaluate the incremental burden of hospitalized hyponatremic (HN) versus non-HN patients in terms of hospital resource utilization, costs, and hospital readmissions in the real-world setting. METHODS: HN patients (≥18 years) were selected from the Premier Hospital Database between January 1, 2007 and March 31, 2010 and matched to a non-HN control cohort using propensity score matching...
October 2012: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/22928607/mortality-and-causes-of-death-in-the-familial-intracranial-aneurysm-study
#14
MULTICENTER STUDY
Laura Sauerbeck, Richard Hornung, Daniel Woo, Charles J Moomaw, Craig Anderson, E Sander Connolly, Guy A Rouleau, Robert D Brown, Joseph P Broderick
BACKGROUND: Higher mortality for patients with aneurysmal subarachnoid haemorrhage has been reported. AIMS: In families with intracranial aneurysms, we sought to determine whether mortality among subjects with intracranial aneurysm (affected) was higher and related to rupture, compared with unaffected family members. METHODS: Subjects enrolled in the Familial Intracranial Aneurysm protocol were contacted yearly and their status was obtained...
December 2013: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/22781717/-expression-and-clinical-significance-of-id1-gene-in-acute-myeloid-leukemia
#15
Ying Lu, Qiong Wang, Qi-tian Mu, Zhi-mei Chen, Ji-yu Lou, Wan-mao Ni, Jie Jin
OBJECTIVE: To explore the expression and clinical significance of ID1 gene in acute myeloid leukemia (AML) patients. METHOD: Real-time quantitative PCR (RQ-PCR) was used to test the expression level of ID1 gene in 114 de novo adult AML patients, and the clinical features of these patients were analyzed. RESULTS: ID1 gene transcript levels were detectable in BM mononuclear cells from 114 patients with AML, the median expression level of all samples was 8525 (range: 57 - 11 233 238)...
April 2012: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/22539557/workplace-field-testing-of-the-pressure-drop-of-particulate-respirators-using-welding-fumes
#16
Hyun-Woo Cho, Chung-Sik Yoon
In a previous study, we concluded that respirator testing with a sodium chloride aerosol gave a conservative estimate of filter penetration for welding fume aerosols. A rapid increase in the pressure drop (PD) of some respirators was observed as fumes accumulated on the filters. The present study evaluated particulate respirator PD based on workplace field tests. A field PD tester was designed and validated using the TSI 8130 Automatic Filter Tester, designed in compliance with National Institute for Occupational and Safety and Health regulation 42 CFR part 84...
October 2012: Annals of Occupational Hygiene
https://www.readbyqxmd.com/read/22033359/dispersion-modelling-of-traffic-induced-ultrafine-particles-in-a-street-canyon-in-antwerp-belgium-and-comparison-with-observations
#17
Irina Nikolova, Stijn Janssen, Peter Vos, Karl Vrancken, Vinit Mishra, Patrick Berghmans
The aim of this study is to investigate the dispersion of ultrafine particles and its spatial distribution in a street canyon and its neighbourhood with the 3D CFD model ENVI-met®. The performance of the model at street scale is evaluated and the importance of the boundary conditions like wind field and traffic emissions on the UFP concentration is demonstrated. To support and validate the modelled results, a short-term measurement campaign was conducted in a street canyon in Antwerp, Belgium. The UFP concentration was measured simultaneously with P-TRACK (TSI Model 8525) at four different locations in the canyon...
December 15, 2011: Science of the Total Environment
https://www.readbyqxmd.com/read/21923120/organization-of-bacteriochlorophylls-in-individual-chlorosomes-from-chlorobaculum-tepidum-studied-by-2-dimensional-polarization-fluorescence-microscopy
#18
Yuxi Tian, Rafael Camacho, Daniel Thomsson, Michael Reus, Alfred R Holzwarth, Ivan G Scheblykin
Chlorosomes are the largest and most efficient natural light-harvesting systems and contain supramolecular assemblies of bacteriochlorophylls that are organized without proteins. Despite a recent structure determination for chlorosomes from Chlorobaculum tepidum (Ganapathy Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 8525), the issue of a possible large structural disorder is still discussed controversially. We have studied individual chlorosomes prepared under very carefully controlled growth condition by a novel 2-dimensional polarization single molecule imaging technique giving polarization information for both fluorescence excitation and emission simultaneously...
November 2, 2011: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/21916440/approximate-and-exact-equations-for-peak-capacity-in-isocratic-high-pressure-liquid-chromatography
#19
COMMENT
Lawrence W Potts, Peter W Carr
In this letter, we examine an equation that had been published in Analytical Chemistry in a paper entitled "Comprehensive Study on the Optimization of Online Two-Dimensional Liquid Chromatographic Systems Considering Losses in Theoretical Peak Capacity in First- and Second-Dimensions: A Pareto-Optimality Approach" by Vivo-Truyols, G.; van der Wal, Sj.; Schoenmakers, P. J. Anal. Chem. 2010, 82, 8525-8536. In that paper, the authors considered, among many issues, the effects of extra-column and column broadening on isocratic peak capacity...
October 15, 2011: Analytical Chemistry
https://www.readbyqxmd.com/read/21475012/outcome-and-cost-analysis-of-sacral-nerve-modulation-for-treating-urinary-and-or-fecal-incontinence
#20
MULTICENTER STUDY
Anne-Marie Leroi, Xavier Lenne, Benoît Dervaux, Emmanuel Chartier-Kastler, Brigitte Mauroy, Loïc Le Normand, Philippe Grise, Jean-Luc Faucheron, Yann Parc, Paul-Antoine Lehur, François Mion, Henri Damon, Xavier Barth, Albert Leriche, Christian Saussine, Laurent Guy, François Haab, Laurent Bresler, Jean-Pierre Sarramon, Henri Bensadoun, Eric Rullier, Karem Slim, Igor Sielezneff, Eric Mourey, Philippe Ballanger, Francis Michot
BACKGROUND: Sacral nerve modulation (SNM) is an established treatment for urinary and fecal incontinence in patients for whom conservative management has failed. OBJECTIVE: This study assessed the outcome and cost analysis of SNM compared to alternative medical and surgical treatments. METHODS: Clinical outcome and cost-effectiveness analyses were performed in parallel with a prospective, multicenter cohort study that included 369 consecutive patients with urge urinary and/or fecal incontinence...
April 2011: Annals of Surgery
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