keyword
https://read.qxmd.com/read/37969778/the-role-of-surgical-therapy-in-the-management-of-premature-ejaculation-a-narrative-review
#21
REVIEW
Hamed Ambusaidi, Muaath Alshuaibi, Ahmed S Zugail, Sebastien Beley
BACKGROUND AND OBJECTIVE: Premature ejaculation (PE) is a common sexual disorder among male adults and negatively impacts a man's sexual life. Currently, the mainstay treatment of PE is still medical therapy which has drawbacks among patients as a consequence of side effects. Despite the new definitions, the evolution of medical therapy, and the consensus for the management of PE, it remains challenging to treat for many clinicians especially when medical treatment fails. However, the International Society for Sexual Medicine (ISSM) and the American Urological Association (AUA) guidelines ignored surgical therapy due to conflicting medical reports and doubts about the safety of surgical management...
October 31, 2023: Translational Andrology and Urology
https://read.qxmd.com/read/37900685/truncated-dnm1-variant-underlines-developmental-delay-and-epileptic-encephalopathy
#22
JOURNAL ARTICLE
Tayyaba Afsar, Xiaoyun Huang, Abid Ali Shah, Safdar Abbas, Shazia Bano, Arif Mahmood, Junjian Hu, Suhail Razak, Muhammad Umair
BACKGROUND: Developmental and epileptic encephalopathies (DEEs) signify a group of heterogeneous neurodevelopmental disorder associated with early-onset seizures accompanied by developmental delay, hypotonia, mild to severe intellectual disability, and developmental regression. Variants in the DNM1 gene have been associated with autosomal dominant DEE type 31A and autosomal recessive DEE type 31B. METHODS: In the current study, a consanguineous Pakistani family consisting of a proband (IV-2) was clinically evaluated and genetically analyzed manifesting in severe neurodevelopmental phenotypes...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/37898606/prognostic-models-predicting-transition-to-psychotic-disorder-using-blood-based-biomarkers-a-systematic-review-and-critical-appraisal
#23
Jonah F Byrne, David Mongan, Jennifer Murphy, Colm Healy, Melanie Fӧcking, Mary Cannon, David R Cotter
Accumulating evidence suggests individuals with psychotic disorder show abnormalities in metabolic and inflammatory processes. Recently, several studies have employed blood-based predictors in models predicting transition to psychotic disorder in risk-enriched populations. A systematic review of the performance and methodology of prognostic models using blood-based biomarkers in the prediction of psychotic disorder from risk-enriched populations is warranted. Databases (PubMed, EMBASE and PsycINFO) were searched for eligible texts from 1998 to 15/05/2023, which detailed model development or validation studies...
October 28, 2023: Translational Psychiatry
https://read.qxmd.com/read/37884086/age-specific-reference-intervals-for-plasma-biomarkers-of-neurodegeneration-and-neurotrauma-in-a-canadian-population
#24
JOURNAL ARTICLE
Jennifer G Cooper, Sophie Stukas, Mohammad Ghodsi, Nyra Ahmed, Ramon Diaz-Arrastia, Daniel T Holmes, Cheryl L Wellington
INTRODUCTION: In this study, we aimed to create reference intervals (RI) using a large Canadian population-based cohort, for plasma protein biomarkers with potential utility to screen, diagnosis, prognosticate and manage a variety of neurological diseases and disorders. RIs were generated for: the ratio of amyloid beta 42 over 40 (Aβ42/40), phosphorylated tau-181 (p-tau-181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP). METHODS: 900 plasma specimens from male and female participants aged 3-79 years old were obtained from the Statistics Canada Biobank, which holds specimens from the Canadian Health Measures Survey...
October 24, 2023: Clinical Biochemistry
https://read.qxmd.com/read/37874403/relationship-between-night-shift-and-sleep-problems-risk-of-metabolic-abnormalities-of-nurses-a-2%C3%A2-years-follow-up-retrospective-analysis-in-the-national-nurse-health-study-nnhs
#25
JOURNAL ARTICLE
Heli Zhang, Jingpin Wang, Siwei Zhang, Sumei Tong, Jinping Hu, Ying Che, Lin Zhuo, Peng Wang, Rongmei Geng, Yujie Zhou, Panfeng Wang, Siyan Zhan, Baohua Li
BACKGROUND AND PURPOSE: Efforts to improve nurses' physical and mental health are critical to ensuring the safety and quality of the healthcare system. Long-term studies targeting the relevancy of nurses' occupation characteristics with health conditions remain insufficient. This study aimed to examine the relationship between nurses' night shift and sleep problems and metabolic abnormalities risk. METHODS: This study was a part of the National Nurse Health Study, an ambispective cohort study in China, in 2021...
October 24, 2023: International Archives of Occupational and Environmental Health
https://read.qxmd.com/read/37801454/-actual-nutrition-in-adults-with-familial-hypercholesterolemia
#26
JOURNAL ARTICLE
A V Blokhina, A I Ershova, O V Kopylova, A S Limonova, N S Karamnova, O B Shvabskaya, A V Kiseleva, S A Derbeneva, A N Meshkov, O M Drapkina
Familial hypercholesterolemia (FH) is a highly atherogenic, genetically based lipid disorder. For patients with FH, dietary modification is the cornerstone of complex lipidlowering therapy. The aim of the research was to assess the actual nutrition in adults with familial hypercholesterolemia. Material and methods . The study included 100 patients over 18 years old (including 46% men) with "probable" or "definite" FH according to the Dutch Lipid Clinic Network or Simon Broome criteria from the GENMOTIV-FH study (ClinicalTrials: NCT04656028) in 2019-2021...
2023: Voprosy Pitaniia
https://read.qxmd.com/read/37792218/consensus-based-recommendations-on-the-use-of-cgrp-based-therapies-for-migraine-prevention-in-the-uae
#27
JOURNAL ARTICLE
Taoufik Alsaadi, Deeb M Kayed, Abubaker Al-Madani, Ali Mohamed Hassan, Alessandro Terruzzi, Derk Krieger, Naji Riachi, Pournamy Sarathchandran, Suhail Al-Rukn
INTRODUCTION: Migraine is a common debilitating neurological disorder affecting a large proportion of the general population. Calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide, plays a key role in the pathophysiology of migraine, and the development of therapies targeting the anti-CGRP pathway has revolutionized the field of migraine treatment. METHODS: An expert task force of neurologists in the United Arab Emirates (UAE) developed and critically assessed recommendations on the use of CGRP-based therapies in migraine treatment and management in the UAE, based on available published literature...
October 4, 2023: Neurology and Therapy
https://read.qxmd.com/read/37789651/efficacy-of-omega-3-fatty-acids-for-hospitalized-covid-19-patients-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#28
JOURNAL ARTICLE
Han-Yang Yue, Jun Zeng, Yu Wang, Meng-Jie Deng, Wei Peng, Xin Tan, Hua Jiang
BACKGROUND AND OBJECTIVES: Emerging expert consensuses and guidelines recommend that omega-3 fatty acids may have anti-inflammatory effects in hospitalized patients with coronavirus disease (COVID-19). However, these recommendations are based on pathophysiological studies of inflammation rather than direct clinical evidence. We conducted this systematic review and meta-analysis to evaluate the efficacy of omega-3 fatty acid supplementation in hospitalized patients with COVID-19. METHODS AND STUDY DESIGN: We retrieved literature from PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), WANFANG, Chinese Biomedical Literature Database, and Cochrane Library databases up to May 1, 2023...
September 2023: Asia Pacific Journal of Clinical Nutrition
https://read.qxmd.com/read/37755267/metabolite-alterations-in-autoimmune-diseases-a-systematic-review-of-metabolomics-studies
#29
REVIEW
Abdulrahman Mujalli, Wesam F Farrash, Kawthar S Alghamdi, Ahmad A Obaid
Autoimmune diseases, characterized by the immune system's loss of self-tolerance, lack definitive diagnostic tests, necessitating the search for reliable biomarkers. This systematic review aims to identify common metabolite changes across multiple autoimmune diseases. Following PRISMA guidelines, we conducted a systematic literature review by searching MEDLINE, ScienceDirect, Google Scholar, PubMed, and Scopus (Elsevier) using keywords "Metabolomics", "Autoimmune diseases", and "Metabolic changes". Articles published in English up to March 2023 were included without a specific start date filter...
September 1, 2023: Metabolites
https://read.qxmd.com/read/37726820/effects-of-long-term-consumption-of-two-plant-based-dietary-supplements-on-cardiovascular-health-and-low-grade-inflammation-in-middle-aged-and-elderly-people-study-protocol-for-a-randomised-controlled-trial
#30
JOURNAL ARTICLE
Melina Tsiountsioura, Gerhard Cvirn, Lisa Meixner-Goetz, Tobias Ziegler, Manfred Lamprecht
BACKGROUND: Ageing is a process characterised by chronic low-grade inflammation and oxidative stress which could lead to increased prevalence of both physical and mental age-related chronic conditions. A healthy balanced diet, rich in fruit and vegetables as well as omega-3 polyunsaturated fatty acids (n3 PUFA), could reduce oxidative stress and improve markers of low-grade inflammation. Nonetheless, considering that a large part of the population struggles to meet current guidelines on fruit and vegetable and n3 PUFA recommendations, fruit and vegetable concentrate supplements and mixed omega fatty acid supplements could be an effective strategy to bridge the gap between actual and recommended intakes...
September 19, 2023: Journal of Health, Population, and Nutrition
https://read.qxmd.com/read/37700848/metabolomics-analysis-of-amino-acid-and-fatty-acids-in-colorectal-cancer-patients-based-on-tandem-mass-spectrometry
#31
JOURNAL ARTICLE
Zhuo Zhao, Jing Bai, Chang Liu, Yansong Wang, Shuang Wang, Furong Zhao, Qiufang Gu
Metabolic differences between colorectal cancer (CRC) and NI (NI) play an important role in early diagnoses and in-time treatments. We investigated the metabolic alterations between CRC patients and NI, and identified some potential biomarkers, and these biomarkers might be used as indicators for diagnosis of CRC. In this study, there were 79 NI, 50 CRC I patients, 52 CRC II patients, 56 CRC III patients, and 52 CRC IV patients. MS-MS was used to measure the metabolic alterations. Univariate and multivariate data analysis and metabolic pathway analysis were applied to analyze metabolic data and determine differential metabolites...
September 2023: Journal of Clinical Biochemistry and Nutrition
https://read.qxmd.com/read/37698821/guidelines-on-optimizing-the-use-of-proton-pump-inhibitors-ppi-stewardship
#32
JOURNAL ARTICLE
Amit Kumar Dutta, Abhinav Jain, Vaneet Jearth, Ramit Mahajan, Manas Kumar Panigrahi, Vishal Sharma, Mahesh Kumar Goenka, Rakesh Kochhar, Govind Makharia, Duvvur Nageshwar Reddy, Richard Kirubakaran, Vineet Ahuja, Neha Berry, Naresh Bhat, Usha Dutta, Uday Chand Ghoshal, Ajay Jain, Umesh Jalihal, V Jayanthi, Ajay Kumar, Sandeep Nijhawan, Ujjal Poddar, G N Ramesh, Shivram P Singh, Showkat Zargar, Shobna Bhatia
Proton pump inhibitors (PPIs) have been available for over three decades and are among the most commonly prescribed medications. They are effective in treating a variety of gastric acid-related disorders. They are freely available and based on current evidence, use of PPIs for inappropriate indications and duration appears to be common. Over the years, concerns have been raised on the safety of PPIs as they have been associated with several adverse effects. Hence, there is a need for PPI stewardship to promote the use of PPIs for appropriate indication and duration...
September 12, 2023: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/37646719/machine-learning-applied-to-cholesterol-lowering-pharmacotherapy-proof-of-concept-in-high-risk-patients-treated-in-primary-care
#33
JOURNAL ARTICLE
Andrew J Krentz, Gabe Haddon-Hill, Xiaoyan Zou, Natalie Pankova, André Jaun
Objectives: Machine learning has potential to improve the management of lipid disorders. We explored the utility of machine learning in high-risk patients in primary care receiving cholesterol-lowering medications. Methods: Machine learning algorithms were created based on lipid management guidelines for England [National Institute for Health and Care Excellence (NICE) CG181] to reproduce the guidance with >95% accuracy. Natural language processing and therapy identification algorithms were applied to anonymized electronic records from six South London primary care general practices to extract medication information from free text fields...
October 2023: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/37610837/guidelines-for-parenteral-nutrition-in-preterm-infants-the-american-society-for-parenteral-and-enteral-nutrition
#34
JOURNAL ARTICLE
Daniel T Robinson, Kara L Calkins, Yimin Chen, M Petrea Cober, Gustave H Falciglia, David D Church, Jacob Mey, Liam McKeever, Timothy Sentongo
BACKGROUND: Parenteral nutrition (PN) is prescribed for preterm infants until nutrition needs are met via the enteral route, but unanswered questions remain regarding PN best practices in this population. METHODS: An interdisciplinary committee was assembled to answer 12 questions concerning the provision of PN to preterm infants. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) process was used. Questions addressed parenteral macronutrient doses, lipid injectable emulsion (ILE) composition, and clinically relevant outcomes, including PNALD, early childhood growth, and neurodevelopment...
August 23, 2023: JPEN. Journal of Parenteral and Enteral Nutrition
https://read.qxmd.com/read/37609738/prescribing-practices-of-tranexamic-acid-for-melasma-delphi-consensus-from-the-pigmentary-disorders-society
#35
JOURNAL ARTICLE
Rashmi Sarkar, Vignesh Narayan R, Keshavamurthy Vinay, Ridhima Lakhani, Surabhi Sinha, Venkataram Mysore, Muthu Sendhil Kumaran, Mala Bhalla, Anupam Das, Bhavesh Swarnkar, Devinder Mohan Thappa, Indrashis Podder, Richa Ojha Sharma, Vijay Kumar Somani, Shyamanta Barua, Soumya Jagadeesan, Sunil Dogra
Introduction There is ambiguity regarding usage of tranexamic acid for melasma in India, be it in its pre-administration evaluation, administration route, dosing or monitoring. Hence, we conducted this study to understand various tranexamic-acid prescribing patterns and provide practical guidelines. Materials and methods A Google-form-based questionnaire (25-questions) was prepared based on the key areas identified by experts from the Pigmentary Disorders Society, India and circulated to practicing dermatologists across the country...
July 21, 2023: Indian Journal of Dermatology, Venereology and Leprology
https://read.qxmd.com/read/37533125/hydro-organic-mobile-phase-and-factorial-design-application-to-attain-green-hplc-method-for-simultaneous-assay-of-paracetamol-and-dantrolene-sodium-in-combined-capsules
#36
JOURNAL ARTICLE
Nora A Abdallah, Manar M Tolba, Amina M El-Brashy, Fawzia A Ibrahim, Mona E Fathy
The greenness of any analytical method has become a very important aspect of a good analytical method. However, most chromatographic methods depend on the usage of relatively large amounts of lethal and un-decaying chemicals and solvents. So, a green approach based on the full factorial design was employed to develop a simple and rapid HPLC technique for concurrent determination of paracetamol and dantrolene sodium in their combined capsules. Both drugs are highly recommended to be administered together in patients with severe musculoskeletal disorders...
August 2, 2023: BMC chemistry
https://read.qxmd.com/read/37460004/recent-advances-in-the-management-and-implementation-of-care-for-familial-hypercholesterolaemia
#37
REVIEW
Nick S R Lan, Archna Bajaj, Gerald F Watts, Marina Cuchel
Familial hypercholesterolaemia (FH) is a common autosomal semi-dominant and highly penetrant disorder of the low-density lipoprotein (LDL) receptor pathway, characterised by lifelong elevated levels of low-density lipoprotein cholesterol (LDL-C) and increased risk of atherosclerotic cardiovascular disease (ASCVD). However, many patients with FH are not diagnosed and do not attain recommended LDL-C goals despite maximally tolerated doses of potent statin and ezetimibe. Over the past decade, several cholesterol-lowering therapies such as those targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) or angiopoietin-like 3 (ANGPTL3) with monoclonal antibody or ribonucleic acid (RNA) approaches have been developed that promise to close the treatment gap...
August 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/37445474/state-of-the-art-in-temporomandibular-joint-arthrocentesis-a-systematic-review
#38
REVIEW
Marta Siewert-Gutowska, Rafał Pokrowiecki, Artur Kamiński, Paweł Zawadzki, Zygmunt Stopa
Temporomandibular joint disorders are a heterogenic group of clinical conditions, which impair physiological functioning of the masticatory system. Arthrocentesis of the temporomandibular joint has become a widely approved method for non-invasive treatment, bridging the gap between conservative and surgical approaches. Regardless of technique, treatment is based upon joint lavage and lysis of the inflammatory fibrous tissue adhesions, which, in turn, improves joint mobility and reduces pain and closed lock...
June 30, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37435405/changes-in-synaptic-markers-after-administration-of-ketamine-or-psychedelics-a-systematic-scoping-review
#39
REVIEW
Simon Zhornitsky, Henrique N P Oliva, Laura A Jayne, Aza S A Allsop, Alfred P Kaye, Marc N Potenza, Gustavo A Angarita
BACKGROUND: Ketamine and psychedelics have abuse liability. They can also induce "transformative experiences" where individuals experience enhanced states of awareness. This enhanced awareness can lead to changes in preexisting behavioral patterns which could be beneficial in the treatment of substance use disorders (SUDs). Preclinical and clinical studies suggest that ketamine and psychedelics may alter markers associated with synaptic density, and that these changes may underlie effects such as sensitization, conditioned place preference, drug self-administration, and verbal memory performance...
2023: Frontiers in Psychiatry
https://read.qxmd.com/read/37398891/paradoxical-association-between-dyspepsia-and-autoimmune-chronic-atrophic-gastritis-insights-into-mechanisms-pathophysiology-and-treatment-options
#40
JOURNAL ARTICLE
Roberta Elisa Rossi, Alessandra Elvevi, Valentina Sciola, Francesco Vito Mandarino, Silvio Danese, Pietro Invernizzi, Sara Massironi
BACKGROUND: Autoimmune gastritis (AIG) is a progressive, chronic, immune-mediated inflammatory disease characterized by the destruction of gastric parietal cells leading to hypo/anacidity and loss of intrinsic factor. Gastrointestinal symptoms such as dyspepsia and early satiety are very common, being second in terms of frequency only to anemia, which is the most typical feature of AIG. AIM: To address both well-established and more innovative information and knowledge about this challenging disorder...
June 21, 2023: World Journal of Gastroenterology: WJG
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