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https://www.readbyqxmd.com/read/29237331/autism-spectrum-disorder-consensus-guidelines-on-assessment-treatment-and-research-from-the-british-association-for-psychopharmacology
#1
Oliver D Howes, Maria Rogdaki, James L Findon, Robert H Wichers, Tony Charman, Bryan H King, Eva Loth, Gráinne M McAlonan, James T McCracken, Jeremy R Parr, Carol Povey, Paramala Santosh, Simon Wallace, Emily Simonoff, Declan G Murphy
An expert review of the aetiology, assessment, and treatment of autism spectrum disorder, and recommendations for diagnosis, management and service provision was coordinated by the British Association for Psychopharmacology, and evidence graded. The aetiology of autism spectrum disorder involves genetic and environmental contributions, and implicates a number of brain systems, in particular the gamma-aminobutyric acid, serotonergic and glutamatergic systems. The presentation of autism spectrum disorder varies widely and co-occurring health problems (in particular epilepsy, sleep disorders, anxiety, depression, attention deficit/hyperactivity disorder and irritability) are common...
December 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29236231/dimethyl-fumarate-a-review-in-moderate-to-severe-plaque-psoriasis
#2
Hannah A Blair
Fumaric acid esters (FAEs) have been used in the treatment of psoriasis in some European countries for over 20 years, and are recommended in the European guidelines for the management of moderate to severe plaque psoriasis. Dimethyl fumarate (Skilarence®; hereafter referred to as DMF) is an orally administered FAE indicated for the treatment of moderate to severe plaque psoriasis in adults in need of systemic medicinal therapy; unlike other available FAEs, it is not formulated in combination with monoethyl fumarate salts...
December 13, 2017: Drugs
https://www.readbyqxmd.com/read/29209235/the-endless-trip-among-the-nps-users-psychopathology-and-psychopharmacology-in-the-hallucinogen-persisting-perception-disorder-a-systematic-review
#3
REVIEW
Laura Orsolini, Gabriele Duccio Papanti, Domenico De Berardis, Amira Guirguis, John Martin Corkery, Fabrizio Schifano
Hallucinogen-persisting perception disorder (HPPD) is a syndrome characterized by prolonged or reoccurring perceptual symptoms, reminiscent of acute hallucinogen effects. HPPD was associated with a broader range of LSD (lysergic acid diethylamide)-like substances, cannabis, methylenedioxymethamphetamine (MDMA), psilocybin, mescaline, and psychostimulants. The recent emergence of novel psychoactive substances (NPS) posed a critical concern regarding the new onset of psychiatric symptoms/syndromes, including cases of HPPD...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29191313/analysis-of-pfaas-in-american-alligators-part-2-potential-dietary-exposure-of-south-carolina-hunters-from-recreationally-harvested-alligator-meat
#4
Jessica J Tipton, Louis J Guillette, Susan Lovelace, Benjamin B Parrott, Thomas R Rainwater, Jessica L Reiner
Exposure to perfluorinated alkyl acids (PFAAs) has been linked to many harmful health effects including reproductive disorders, developmental delays, and altered liver and kidney function. Most human exposure to environmental contaminants, including PFAAs, occurs through consumption of contaminated food or drinking water. This study uses PFAA data from meat samples collected from recreationally harvested American alligators (Alligator mississippiensis) in South Carolina to assess potential dietary exposure of hunters and their families to PFAAs...
November 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29037239/serum-uric-acid-and-non-alcoholic-fatty-liver-disease-in-non-obesity-chinese-adults
#5
Xiaoya Zheng, Lilin Gong, Rong Luo, Hua Chen, Bin Peng, Wei Ren, Yonghong Wang
BACKGROUND: Previous studies found elevated serum uric acid (SUA) was associated with the development or progression of non-alcoholic fatty liver disease (NAFLD) in general population; in this study we aim to investigate the association of SUA and the severity of NAFLD based on grade of fatty liver on ultrasonography in non-obese subjects. METHODS: Data were obtained from subjects via routine physical examinations in the Public Health Center of our hospital between 2011 and 2014...
October 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28974744/variations-of-parathyroid-hormone-and-bone-biomarkers-are-concordant-only-after-a-long-term-follow-up-in-hemodialyzed-patients
#6
Pierre Delanaye, Xavier Warling, Martial Moonen, Nicole Smelten, François Jouret, Jean-Marie Krzesinski, Nicolas Maillard, Hans Pottel, Etienne Cavalier
End-stage renal disease is associated with mineral and bone disorders. Guidelines recommending therapies should be based on serial assessments of biomarkers, and thus on variations (Δ), rather than scattered values. We analyzed the correlations between ΔPTH and Δbone biomarkers such as bone-specific alkaline phosphatase (b-ALP), Beta-CrossLaps (CTX), osteocalcin, intact serum procollagen type-1 N-propeptide (P1NP), and tartrate-resistant acid phosphatase 5B (TRAP-5B) at different time-points. In this prospective observational analysis, variations of biomarkers were followed after 6-week (n = 129), 6-month (n = 108) and one-year (n = 93) period...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28948708/variation-in-esophageal-physiology-testing-in-clinical-practice-results-from-an-international-survey
#7
R Sweis, H Heinrich, M Fox
BACKGROUND: Advances in clinical measurement of esophageal motility and function have improved the assessment of swallowing disorders and reflux symptoms. Variation in data acquisition, analysis, and reporting exists and impacts on diagnosis and management. AIMS AND METHODS: This study examined variation in esophageal manometry methodology between institutions to establish the status in current practice. A structured survey was distributed through international NGM societies using an Internet-based platform...
September 25, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28655027/zolpidem-for-the-treatment-of-neurologic-disorders-a-systematic-review
#8
REVIEW
Martin N Bomalaski, Edward S Claflin, Whitney Townsend, Mark D Peterson
Importance: Given its selective action on the ω1 subtype of the γ-aminobutyric acid A receptor, zolpidem tartrate presents a potential treatment mechanism for other neurologic disorders. Objective: To synthesize studies that used zolpidem to treat neurologic disorders. Evidence Review: Eligibility criteria included any published English-language article that examined the use of zolpidem for noninsomnia neurologic disorders in humans for all dates up to March 20, 2015...
September 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28581835/development-and-gamma-scintigraphy-evaluation-of-gastro-retentive-calcium-ion-based-oral-formulation-an-innovative-approach-for-the-management-of-gastro-esophageal-reflux-disease-gerd
#9
Braj Gaurav Sharma, Kushagra Khanna, Neeraj Kumar, Dhruv K Nishad, Mitra Basu, Aseem Bhatnagar
Calcium chloride is an essential calcium channel agonist which plays an important role in the contraction of muscles by triggering calcium channel. First time hypothesized about its role in the treatment of GER (gastro-esophageal reflux) and vomiting disorder due to its local action. There are two objectives covered in this study as first, the development and optimization of floating formulation of calcium chloride and another objective was to evaluate optimized formulation through gamma scintigraphy in human subjects...
November 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28556266/identification-of-stress-degradation-products-of-iloperidone-using-liquid-chromatography-coupled-with-orbitrap-mass-spectrometer
#10
Sukanya Pandeti, Tofan Kumar Rout, T Narender, Thota Jagadeshwar Reddy
RATIONALE: Iloperidone (ILOP) is atypical antipsychotic drug used for the treatment of schizophrenia and related psychotic disorders. Comprehensive stress testing of ILOP drug was carried out as per ICH guidelines to understand the degradation profile of the drug. The presence of degradation products in a drug affects not only the quality, but also the safety and efficacy of drug formulation. Thus, it is essential to develop an efficient analytical method which could be useful for the separation, identification and characterization of all possible degradation products of ILOP...
May 26, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28497085/evaluation-of-water-and-electrolytes-disorders-in-severe-acute-diarrhea-patients-treated-by-who-protocol-in-eight-large-hospitals-in-tehran-a-nephrology-viewpoint
#11
Alireza Soleimani, Fatemeh Foroozanfard, Mohammad Reza Tamadon
Introduction: The most common cause of death from diarrhea is the shock caused by dehydration, electrolytes and acid-base disorders. Objectives: The aim of this study was to evaluate water and electrolytes disorders in diarrhea patients after treating severe acute diarrhea. Patients and Methods: In this study we used a historical cohort and studied patients who were hospitalized due to acute diarrhea and were similarly treated for dehydration and water and electrolyte disorders as recommended by the World Health Organization (WHO) guideline...
2017: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/28495603/ethnopharmacological-uses-phytochemistry-biological-activities-and-therapeutic-applications-of-clinacanthus-nutans-burm-f-lindau-a-comprehensive-review
#12
REVIEW
Muhamad Noor Alfarizal Kamarudin, Md Moklesur Rahman Sarker, Habsah Abdul Kadir, Long Chiau Ming
ETHNOPHARMACOLOGICAL RELEVANCE: Clinacanthus nutans (Burm. f.) Lindau, a widely used medicinal plant, is extensively grown in tropical Asia and Southeast Asian countries. C. nutans, with its broad spectrum of pharmacological activities, has been traditionally used to treat cancer, inflammatory disorders, diabetes, insect bites, and skin problems, consumed as a vegetable, mixed with fresh juices, in concoctions, and as a whole plant. The present review analyzes the advances in the ethnopharmacology, phytochemistry, pharmacology, and toxicology of C...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28379964/body-weight-affects-%C3%AF-3-polyunsaturated-fatty-acid-pufa-accumulation-in-youth-following-supplementation-in-post-hoc-analyses-of-a-randomized-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
Lisa M Christian, Andrea S Young, Amanda M Mitchell, Martha A Belury, Barbara L Gracious, L Eugene Arnold, Mary A Fristad
Guidelines for suggested intake of ω-3 polyunsaturated fatty acids (PUFAs) are limited in youth and rely primarily on age. However, body weight varies considerably within age classifications. The current analyses examined effects of body weight and body mass index (BMI) on fatty acid accumulation in 64 youth (7-14 years) with a diagnosed mood disorder in a double-blind randomized-controlled trial (2000mg ω-3 supplements or a control capsule) across 12 weeks. Weight and height were measured at the first study visit and EPA and DHA levels were determined using fasting blood samples obtained at both the first and end-of-study visits...
2017: PloS One
https://www.readbyqxmd.com/read/28365882/proteus-a-random-forest-classifier-to-predict-disorder-to-order-transitioning-binding-regions-in-intrinsically-disordered-proteins
#14
Sankar Basu, Fredrik Söderquist, Björn Wallner
The focus of the computational structural biology community has taken a dramatic shift over the past one-and-a-half decades from the classical protein structure prediction problem to the possible understanding of intrinsically disordered proteins (IDP) or proteins containing regions of disorder (IDPR). The current interest lies in the unraveling of a disorder-to-order transitioning code embedded in the amino acid sequences of IDPs/IDPRs. Disordered proteins are characterized by an enormous amount of structural plasticity which makes them promiscuous in binding to different partners, multi-functional in cellular activity and atypical in folding energy landscapes resembling partially folded molten globules...
May 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28338025/preventing-perioperative-bleeding-in-patients-with-inherited-bleeding-disorders
#15
Colin Watterson, Nicholas Beacher
Data sourcesCochrane Cystic Fibrosis and Genetic Disorders Group's Coagulopathies Trials Register, a regularly updated database informed by trials identified within electronic databases including MEDLINE. Further defined searches were undertaken in PubMed, Embase, The Cochrane Library, ClinicalTrials.gov and WHO International Clinical Trials Registry Platform. Additional hand searching of relevant journals and books of conference proceedings was undertaken.Study selectionRandomised and quasi-randomised controlled trials in people of all ages with haemophilia or VWD undergoing oral or dental procedures using antifibrinolytic agents (tranexamic acid (TXA) or epsilon aminocaproic acid (EACA)) to prevent perioperative bleeding compared to no intervention with or without placebo...
March 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28283894/treatment-of-porokeratosis-a-systematic-review
#16
REVIEW
Till Weidner, Tanja Illing, Diana Miguel, Peter Elsner
BACKGROUND: Porokeratosis (PK) is a rare skin disease of unknown etiology. It consists of a keratinization disorder, which may appear in several clinical forms and can undergo malignant transformation. The histopathological hallmark of PK is the cornoid lamella. While many topical, systemic, and surgical treatment modalities for PK have been described, no randomized controlled trials have been performed yet. Because of a lack of treatment standards for PK, European and international guidelines cannot be created...
August 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28202499/dietary-phytochemical-intake-from-foods-and-health-outcomes-a-systematic-review-protocol-and-preliminary-scoping
#17
Yasmine C Probst, Vivienne X Guan, Katherine Kent
INTRODUCTION: Dietary phytochemicals are found in plant-based foods such as fruits, vegetables and grains and may be categorised in a nested hierarchical manner with many hundred individual phytochemicals identified to date. To associate phytochemical intakes with positive health outcomes, a fundamental step is to accurately estimate the dietary phytochemical intake from foods reported. The purpose of this systematic review protocol is to describe the process to be undertaken to summarise the evidence for food-based dietary phytochemical intakes and health outcomes for adults...
February 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/27981857/effective-modified-conservative-tissue-preserving-protocol-to-treat-stage-i-axillary-hidradenitis-suppurativa-a-prospective-cohort-study-of-627-patients-with-five-years-follow-up
#18
Bader Hamza Shirah, Hamza Asaad Shirah
BACKGROUND: Hidradenitis suppurativa is a chronic inflammatory cutaneous disorder that involves the infundibular terminal follicles in areas rich in apocrine glands and associated with the formation of abscesses and fistulating sinus. The clinical course is variable, and definitive evidence-based guidelines for the management are not well-established. Conservative treatment is controversial, and surgical excision is the recommended method. Herein, we aim to analyze the results of a modified conservative tissue preserving management protocol for stage I axillary hidradenitis suppurativa...
January 12, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27894793/a-quick-reference-on-anion-gap-and-strong-ion-gap
#19
REVIEW
Carlos Torrente Artero
Metabolic acid-base disorders are common in emergency and critically ill patients. Clinicians may have difficulty recognizing their presence when multiple acid-base derangements are present in a single patient simultaneously. The anion gap and the strong ion gap concepts are useful calculations to identify the components of complex metabolic acid-base associated to the presence of unmeasured anions. This article presents their definition, normal values, indications, limitations, and guidelines for interpretation of changes in the clinical setting...
March 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/27665489/exercise-induced-bronchoconstriction-update-2016
#20
John M Weiler, John D Brannan, Christopher C Randolph, Teal S Hallstrand, Jonathan Parsons, William Silvers, William Storms, Joanna Zeiger, David I Bernstein, Joann Blessing-Moore, Matthew Greenhawt, David Khan, David Lang, Richard A Nicklas, John Oppenheimer, Jay M Portnoy, Diane E Schuller, Stephen A Tilles, Dana Wallace
The first practice parameter on exercise-induced bronchoconstriction (EIB) was published in 2010. This updated practice parameter was prepared 5 years later. In the ensuing years, there has been increased understanding of the pathogenesis of EIB and improved diagnosis of this disorder by using objective testing. At the time of this publication, observations included the following: dry powder mannitol for inhalation as a bronchial provocation test is FDA approved however not currently available in the United States; if baseline pulmonary function test results are normal to near normal (before and after bronchodilator) in a person with suspected EIB, then further testing should be performed by using standardized exercise challenge or eucapnic voluntary hyperpnea (EVH); and the efficacy of nonpharmaceutical interventions (omega-3 fatty acids) has been challenged...
November 2016: Journal of Allergy and Clinical Immunology
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