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https://www.readbyqxmd.com/read/29337659/determination-of-five-tetracyclines-and-their-epimers-by-lc-ms-ms-based-on-a-liquid-liquid-extraction-with-low-temperature-partitioning
#1
Aurélien Desmarchelier, Sébastien Anizan, Mai Minh Tien, Marie-Claude Savoy, Cindy Bion
A LC-MS/MS method is presented for screening five tetracyclines and their epimers in a broad range of food products. The scope of matrices includes meat-, fish-, seafood-based products, various dairy ingredients, infant formulae and fats. The method principle is based on a liquid-liquid extraction with aqueous ethylenediaminetetraacetic acid (EDTA) and acetonitrile followed by a freezing step to promote phase separation at low temperature. After defatting with hexane, sample extracts were evaporated and reconstituted before injection onto the LC-MS/MS system...
January 16, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29317274/skin-corrosion-test-comparison-between-reconstructed-human-epidermis-and-full-thickness-skin-models
#2
Carolina Motter Catarino, Tatiana do Nascimento Pedrosa, Paula Comune Pennacchi, Silvia Romano de Assis, Fabrícia Gimenes, Márcia Edilaine Lopes Consolaro, Silvia Berlanga de Moraes Barros, Silvya Stuchi Maria-Enlger
Currently, there is a strong global trend towards the development of in vitro models to replace the use of animals in safety evaluation tests. Reconstructed Human Epidermis (RHE) models have been employed as an alternative method to animal testing of skin corrosion and irritation potential of chemical compounds. However, the consequences of an absence of the dermal compartment in these models should be considered since the cross-talk between fibroblasts and keratinocytes is fundamental for promoting proper epidermal stratification, homeostasis, inflammatory response and wound healing...
January 6, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29315954/development-and-validation-of-an-assay-to-analyze-atazanavir-in-human-hair-via-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms
#3
Nhi Phung, Karen Kuncze, Hideaki Okochi, Alexander Louie, Leslie Z Benet, Igho Ofokotun, David W Haas, Judith S Currier, Tariro D Chawana, Anandi N Sheth, Peter Bacchetti, Monica Gandhi, Howard Horng
Assays to quantify antiretrovirals in hair samples are increasingly used to monitor adherence and exposure in both HIV prevention and treatment studies. Atazanavir (ATV) is a protease inhibitor used in combination antiretroviral therapy (ART). We developed and validated a liquid chromatography tandem mass spectrometry (LC-MS/MS)-based method to quantify ATV in human hair, per the NIH Division of AIDS' Clinical Pharmacology Quality Assurance (CPQA) program and the FDA bioanalytical method validation guidelines...
January 9, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29312973/critical-appraisal-of-chinese-2017-guideline-on-the-management-of-hepatocellular-carcinoma
#4
REVIEW
Di-Yang Xie, Zheng-Gang Ren, Jian Zhou, Jia Fan, Qiang Gao
Hepatocellular carcinoma (HCC) is the fourth most common and the third most lethal cancer in China. An updated version of consensus-based recommendations on the management of HCC has been recently published by a multidisciplinary group of Chinese experts including liver surgeons, hepatic oncologists, radiologists and pathologists. Major changes have been made to the diagnostic criteria. In addition to dynamic multi-detector computed tomography (CT) and magnetic resonance imaging (MRI), gadoxetic acid-enhanced MRI and contrast-enhanced ultrasound (CEUS) are added to the diagnostic imaging tests...
December 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29310724/effect-of-long-term-nutraceutical-and-dietary-supplement-use-on-cognition-in-the-elderly-a-10-year-systematic-review-of-randomised-controlled-trials
#5
Nathan M D'Cunha, Ekavi N Georgousopoulou, Lakshika Dadigamuwage, Jane Kellett, Demosthenes B Panagiotakos, Jackson Thomas, Andrew J McKune, Duane D Mellor, Nenad Naumovski
Nutraceuticals have generated interest as a way to mitigate the cognitive decline in older adults. The aim of this systematic review was to determine the evidence for these claims from the scientific literature in randomised, double-blinded, controlled trials (duration: ≥1 year; participants: n≥100; age(mean): ≥65 years). Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched four electronic databases (PubMed, Scopus, CINAHL and Web of Science) and identified twenty-five studies published between the 15·June·2006 and 14·June·2016...
January 9, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29310350/relationship-between-skeletal-muscle-mass-and-liver-fibrosis-markers-for-patients-with-hepatitis-c-virus-related-liver-disease
#6
Ryo Takata, Hiroki Nishikawa, Hirayuki Enomoto, Yoshinori Iwata, Akio Ishii, Yuho Miyamoto, Noriko Ishii, Yukihisa Yuri, Kunihiro Hasegawa, Chikage Nakano, Takashi Nishimura, Kazunori Yoh, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
We aimed to elucidate the relationship between serum liver fibrosis markers (Mac-2 binding protein glycosylation isomer (M2BPGi), FIB-4 index, aspartate aminotransferase to platelet ratio index and hyaluronic acid), and skeletal muscle mass and to investigate factors linked to skeletal muscle mass loss (SMML) in patients with chronic hepatitis C (CHC, n = 277, median age = 64 years). We defined patients with psoas muscle index [PMI, sum of bilateral psoas muscle mass calculated by manual trace method at the lumber 3 level on the computed tomography images divided by height squared (cm/m)] less than 6...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29302148/association-of-risk-factors-and-drug-resistance-pattern-in-tuberculosis-patients-in-north-india
#7
Pallavi Sinha, G N Srivastava, Anamika Gupta, Shampa Anupurba
Context: India is one of the high tuberculosis (TB) burden countries in the world. Improper implementation in the guidelines for the management of TB and high rate of defaults on the part of the patients are most important risk factors for the development of multi-drug resistant TB. Aims: This study examines the drug resistance profile and the effect of demographic, clinical and behavioral risk factors on the prevalence of TB and multidrug resistance (MDR) in north India...
October 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29289290/toxicities-and-risk-assessment-of-heavy-metals-in-sediments-of-taihu-lake-china-based-on-sediment-quality-guidelines
#8
Yanfeng Zhang, Yuwei Han, Jinxi Yang, Lingyan Zhu, Wenjue Zhong
The occurrence, toxicities, and ecological risks of five heavy metals (Pb, Cu, Cd, Zn and Ni) in the sediment of Taihu Lake were investigated in this study. To evaluate the toxicities caused by the heavy metals, the toxicities induced by organic contaminants and ammonia in the sediments were screened out with activated carbon and zeolite. The toxicities of heavy metals in sediments were tested with benthic invertebrates (tubificid and chironomid). The correlations between toxicity of sediment and the sediment quality guidelines (SQGs) derived previously were evaluated...
December 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29283898/compliance-with-the-aaos-guidelines-for-treatment-of-osteoarthritis-of-the-knee-a-survey-of-the-american-association-of-hip-and-knee-surgeons
#9
Victor Rex Carlson, Alvin Chua Ong, Fabio Ramiro Orozco, Victor Hugo Hernandez, Rex William Lutz, Zachary Douglas Post
INTRODUCTION: The American Academy of Orthopaedic Surgeons (AAOS) published a series of evidence-based guidelines for treatment of knee osteoarthritis (OA). We studied compliance with these guidelines among orthopaedic surgeons. METHODS: We sent a survey to members of the American Association of Hip and Knee Surgeons. It included five clinical vignettes based on the Kellgren-Lawrence radiographic system for classification of knee OA. Respondents selected treatment currently supported or not supported by the AAOS guidelines...
December 22, 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29278655/eosinophilic-esophagitis-in-japan-focus-on-response-to-acid-suppressive-therapy
#10
REVIEW
Norihisa Ishimura, Yoshikazu Kinoshita
Eosinophilic esophagitis (EoE) is a chronic inflammatory condition characterized by esophageal dysfunction and dense eosinophilic infiltration of esophageal epithelium. According to clinical consensus and guidelines published in 2011, esophageal eosinophilia was classified into 2 entities based on response to proton pump inhibitor (PPI) administration; EoE and PPI-responsive esophageal eosinophilia (PPI-REE). We have performed a series of investigations to determine whether EoE is actually different from PPI-REE...
December 26, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29277222/discharged-filtrate-movement-in-food-materials-under-application-of-electrokinetics
#11
H Iessa, K Christensen, J A Hall, C J Seal
Orange juice (OJ) and malt extract (ME) samples were treated using an electrokinetic (EK) application to investigate the impact of the pH/Lowest conductivity point (LCP) ratio of experimental materials on the water profile direction and the anolyte to catholyte filtrate ratio. After applying the electric field through samples between two electrodes, filtrate was discharged mainly towards the anode in OJ samples (acidic medium, pH/LCP < 1) and towards the cathode in ME samples (alkaline medium, pH/LCP > 1)...
May 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29261810/whole-genome-microarray-analysis-of-neural-progenitor-c17-2-cells-during-differentiation-and-validation-of-30-neural-mrna-biomarkers-for-estimation-of-developmental-neurotoxicity
#12
Kristina Attoff, Anda Gliga, Jessica Lundqvist, Ulf Norinder, Anna Forsby
Despite its high relevance, developmental neurotoxicity (DNT) is one of the least studied forms of toxicity. Current guidelines for DNT testing are based on in vivo testing and they require extensive resources. Transcriptomic approaches using relevant in vitro models have been suggested as a useful tool for identifying possible DNT-generating compounds. In this study, we performed whole genome microarray analysis on the murine progenitor cell line C17.2 following 5 and 10 days of differentiation. We identified 30 genes that are strongly associated with neural differentiation...
2017: PloS One
https://www.readbyqxmd.com/read/29260323/occurrences-and-changes-of-disinfection-by-products-in-small-water-supply-systems
#13
Shakhawat Chowdhury
The small water supply systems (WSSs) often report high concentrations of disinfection by-products (DBPs) in drinking water. In this study, occurrences of trihalomethanes (THMs) and haloacetic acids (HAAs) in Newfoundland and Labrador (NL), Canada, were investigated from 441 WSSs for a period of 18 years (1999-2016). The WSSs were divided into groundwater (GWP) and surface water (SWP) systems, which were further classified into eight sub-groups (P1-P8) based on the population served (≤ 100; 101-250; 251-500; 501-1000; 1001-3000; 3001-5000; 5001-10,000; and 10,000+, respectively)...
December 20, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29248769/an-improved-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms-method-for-quantification-of-dexmedetomidine-concentrations-in-samples-of-human-plasma
#14
Seyed Mojtaba Moosavi, Kiran Shekar, John F Fraser, Maree T Smith, Sussan Ghassabian
Dexmedetomidine (DMET) is a sedative, analgesic and anxiolytic with minimum adverse respiratory effects. An LC-MS/MS bioanalytical method has been developed and validated to accurately measure DMET concentrations in samples of human plasma. The method overcomes difficulties in the extraction and quantification of DMET due to the fact that it binds strongly to glass and plastic tubes, as well as solid phase extraction (SPE) cartridges. Human plasma (50 μL) was mixed with the internal standard (IS) (DMET-d4) solution (100 μL) and 0...
December 5, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29240760/novel-linear-motif-filtering-protocol-reveals-the-role-of-the-lc8-dynein-light-chain-in-the-hippo-pathway
#15
Gábor Erdős, Tamás Szaniszló, Mátyás Pajkos, Borbála Hajdu-Soltész, Bence Kiss, Gábor Pál, László Nyitray, Zsuzsanna Dosztányi
Protein-protein interactions (PPIs) formed between short linear motifs and globular domains play important roles in many regulatory and signaling processes but are highly underrepresented in current protein-protein interaction databases. These types of interactions are usually characterized by a specific binding motif that captures the key amino acids shared among the interaction partners. However, the computational proteome-level identification of interaction partners based on the known motif is hindered by the huge number of randomly occurring matches from which biologically relevant motif hits need to be extracted...
December 14, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29237331/autism-spectrum-disorder-consensus-guidelines-on-assessment-treatment-and-research-from-the-british-association-for-psychopharmacology
#16
Oliver D Howes, Maria Rogdaki, James L Findon, Robert H Wichers, Tony Charman, Bryan H King, Eva Loth, Gráinne M McAlonan, James T McCracken, Jeremy R Parr, Carol Povey, Paramala Santosh, Simon Wallace, Emily Simonoff, Declan G Murphy
An expert review of the aetiology, assessment, and treatment of autism spectrum disorder, and recommendations for diagnosis, management and service provision was coordinated by the British Association for Psychopharmacology, and evidence graded. The aetiology of autism spectrum disorder involves genetic and environmental contributions, and implicates a number of brain systems, in particular the gamma-aminobutyric acid, serotonergic and glutamatergic systems. The presentation of autism spectrum disorder varies widely and co-occurring health problems (in particular epilepsy, sleep disorders, anxiety, depression, attention deficit/hyperactivity disorder and irritability) are common...
December 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29236231/dimethyl-fumarate-a-review-in-moderate-to-severe-plaque-psoriasis
#17
Hannah A Blair
Fumaric acid esters (FAEs) have been used in the treatment of psoriasis in some European countries for over 20 years, and are recommended in the European guidelines for the management of moderate to severe plaque psoriasis. Dimethyl fumarate (Skilarence®; hereafter referred to as DMF) is an orally administered FAE indicated for the treatment of moderate to severe plaque psoriasis in adults in need of systemic medicinal therapy; unlike other available FAEs, it is not formulated in combination with monoethyl fumarate salts...
December 13, 2017: Drugs
https://www.readbyqxmd.com/read/29235694/calling-all-archaeologists-guidelines-for-terminology-methodology-data-handling-and-reporting-when-undertaking-and-reviewing-stable-isotope-applications-in-archaeology
#18
Patrick Roberts, Ricardo Fernandes, Oliver E Craig, Thomas Larsen, Alexandre Lucquin, Jillian Swift, Jana Zech
Stable isotope analysis has been utilized in archaeology since the 1970s, yet standardized protocols for terminology, sampling, pretreatment evaluation, calibration, quality assurance and control, data presentation, and graphical or statistical treatment still remain lacking in archaeological applications. Here, we present recommendations and requirements for each of these in the archaeological context of: bulk stable carbon and nitrogen isotope analysis of organics; bulk stable carbon and oxygen isotope analysis of carbonates; single compound stable carbon and nitrogen isotope analysis on amino acids in collagen and keratin; and single compound stable carbon and hydrogen isotope analysis on fatty acids...
December 13, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29228998/capturing-health-and-eating-status-through-a-nutritional-perception-screening-questionnaire-npsq9-in-a-randomised-internet-based-personalised-nutrition-intervention-the-food4me-study
#19
Rodrigo San-Cristobal, Santiago Navas-Carretero, Carlos Celis-Morales, Katherine M Livingstone, Barbara Stewart-Knox, Audrey Rankin, Anna L Macready, Rosalind Fallaize, Clare B O'Donovan, Hannah Forster, Clara Woolhead, Marianne C Walsh, Christina P Lambrinou, George Moschonis, Yannis Manios, Miroslaw Jarosz, Hannelore Daniel, Eileen R Gibney, Lorraine Brennan, Thomas E Gundersen, Christian A Drevon, Mike Gibney, Cyril F M Marsaux, Wim H M Saris, Julie A Lovegrove, Lynn J Frewer, John C Mathers, J Alfredo Martinez
BACKGROUND: National guidelines emphasize healthy eating to promote wellbeing and prevention of non-communicable diseases. The perceived healthiness of food is determined by many factors affecting food intake. A positive perception of healthy eating has been shown to be associated with greater diet quality. Internet-based methodologies allow contact with large populations. Our present study aims to design and evaluate a short nutritional perception questionnaire, to be used as a screening tool for assessing nutritional status, and to predict an optimal level of personalisation in nutritional advice delivered via the Internet...
December 11, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29224408/oral-anticoagulation-therapy-upon-discharge-in-hospitalized-patients-with-nonvalvular-atrial-fibrillation-a-retrospective-cohort-study
#20
Devada Singh-Franco, Genevieve Hale, Robin J Jacobs
OBJECTIVES: Availability of direct oral anticoagulants and CHA2DS2VASc/HAS-BLED scoring tools underscore the importance of appropriate and safe use of oral anticoagulation therapy (OACT). The purpose of this study was to evaluate stroke prevention pharmacotherapy in adult patients with nonvalvular atrial fibrillation (NVAF) discharged from a large, community-based hospital. METHODS: A retrospective cohort study was conducted using a de-identified data collection sheet for data extraction (demographics, admitting diagnosis, OACT prior to admission and at discharge, concomitant medications that could increase bleed risk and/or acid-suppressive therapies)...
December 11, 2017: Hospital Practice (Minneapolis)
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