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"Ferric citrate"

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https://www.readbyqxmd.com/read/28722332/functionalized-acupuncture-needle-as-surface-enhanced-resonance-raman-spectroscopy-sensor-for-rapid-and-sensitive-detection-of-dopamine-in-serum-and-cerebrospinal-fluid
#1
Liangbao Yang, Pan Li, Binbin Zhou, Xiaomin Cao, Xianghu Tang, Ling Hu, Jinhuai Liu
It is challenging to develop a robust sensor for simple and rapid operation and sensitive detection of neurotransmitter in complex specimen. In the present work, the ferric-citrate-functionalized Au nanoparticles [Au NPs/CA-Fe(III)] is utilized to develop a facile sensor based on Surface-enhanced Resonance Raman spectroscopy (SERRS) for sensitive detection of dopamine (DA). The sensor is prepared by decorating acupuncture needle with Au NPs, which enables the sufficient SERS enhancement. CA-Fe(III) structure was highly sensitive and selective to DA with formation of CA-Fe(III)-DA resonant structure, indicating the advantages of capturing, carrying and separating DA molecules from complicated samples with simple operation...
July 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28642302/residual-erythropoiesis-protects-against-myocardial-hemosiderosis-in-transfusion-dependent-thalassemia-by-lowering-labile-plasma-iron-via-transient-generation-of-apotransferrin
#2
Maciej W Garbowski, Patricia Evans, Evangelia Vlachodimitropoulou, Robert Hider, John B Porter
Cardiosiderosis is a leading cause of mortality in transfusion-dependent thalassemias. Plasma non-transferrin-bound iron and its redox-active component, labile plasma iron, are key sources of iron loading in cardiosiderosis. Risk factors were identified in 73 patients with or without cardiosiderosis. Soluble transferrin receptor-1 levels were significantly lower in patients with cardiosiderosis (odds ratio 21). This risk increased when transfusion-iron loading rates exceeded the erythroid transferrin uptake rate (derived from soluble transferrin receptor-1) by >0...
June 22, 2017: Haematologica
https://www.readbyqxmd.com/read/28584909/a-review-of-phosphate-binders-in-chronic-kidney-disease-incremental-progress-or-just-higher-costs
#3
REVIEW
Wendy L St Peter, Lori D Wazny, Eric Weinhandl, Katie E Cardone, Joanna Q Hudson
As kidney disease progresses, phosphorus retention also increases, and phosphate binders are used to treat hyperphosphatemia. Clinicians prescribe phosphate binders thinking that reducing total body burden of phosphorus may decrease risks of mineral and bone disorder, fractures, cardiovascular disease, progression of kidney disease, and mortality. Recent meta-analyses suggest that sevelamer use results in lower mortality than use of calcium-containing phosphate binders. However, studies included in meta-analyses show significant heterogeneity, and exclusion or inclusion of specific studies alters results...
July 2017: Drugs
https://www.readbyqxmd.com/read/28561732/ferric-citrate-controls-serum-phosphorus-in-dialysis-patients-retrospective-data%C3%A2
#4
Debra J Hain, Meredith Marinaro, David W Koeper, Melissa A Rosenthal, Salvatore Chillemi, Jennifer M Huffman, Teresa Gerbeling, James M Pritsiolas, Lisa C Loram, Pablo E Pergola
Ferric citrate is an approved phosphate binder for use in patients with chronic kidney disease on dialysis. Clinical trials demonstrated that ferric citrate controlled serum phosphorus levels and increased iron stores. The aim of this retrospective chart review was to evaluate real-world bone mineral and anemia parameter data from patients treated with ferric citrate. 92 adult dialysis patients taking ferric citrate (average starting dose of 6 tablets/day) for at least 6 months were included. Bone mineral, anemia, and iron biomarker levels were extracted from patient medical records before and during the first 6 months of ferric citrate treatment; 21 (23%) patients were phosphate binder naïve, and 71 (77%) patients had been on other phosphate binders...
July 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28531849/heterotrophy-of-filamentous-oleaginous-microalgae-tribonema-minus-for-potential-production-of-lipid-and-palmitoleic-acid
#5
Wenjun Zhou, Hui Wang, Lin Chen, Wentao Cheng, Tianzhong Liu
Heterotrophic fermentation and high valuable co-product producing are thought to be effective ways to improve the economic viability and feasibility of commercial production of microalgae biofuels. This work reported the heterotrophic cultivation of Tribonema minus for lipid and palmitoleic acid (a novel functional fatty acid) production. Firstly, the heterotrophic ability of T. minus was identified for the first time with significant promotion in biomass and lipid productivity, and glucose and urea were then selected as the optimal carbon and nitrogen sources...
September 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28392783/agro-industrial-wastes-for-production-of-biosurfactant-by-bacillus-subtilis-anr-88-and-its-application-in-synthesis-of-silver-and-gold-nanoparticles
#6
Ashwini N Rane, Vishakha V Baikar, D V Ravi Kumar, Rajendra L Deopurkar
Biosurfactants, surface-active amphiphilic compounds, despite having a wide range of applications, have a high cost of production, which severely restricts their use. For cheaper production of biosurfactant, we investigated the potential of the indigenously isolated biosurfactant producing organism, Bacillus subtilis ANR 88, to grow on different cheap carbon sources (molasses, whey, and extracts of potato peels, orange peels, banana peels, and bagasse). We found that, B. subtilis ANR 88 used significant amounts of total sugar to produce cell biomass and biosurfactant...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28373869/the-role-of-enriched-microbial-consortium-on-iron-reducing-bioaugmentation-in-sediments
#7
Yuanyuan Pan, Xunan Yang, Meiying Xu, Guoping Sun
Microbial iron reduction is an important biogeochemical process and involved in various engineered processes, including the traditional clay dyeing processes. Bioaugmentation with iron reducing bacteria (IRB) is generally considered as an effective method to enhance the activity of iron reduction. However, limited information is available about the role of IRB on bioaugmentation. To reveal the roles of introduced IRB on bioaugmentation, an IRB consortium enriched with ferric citrate was inoculated into three Fe(II)-poor sediments which served as the pigments for Gambiered Guangdong silk dyeing...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28248961/effects-of-different-phosphate-lowering-strategies-in-patients-with-ckd-on-laboratory-outcomes-a-systematic-review-and-nma
#8
Nigar Sekercioglu, Argie Angeliki Veroniki, Lehana Thabane, Jason W Busse, Noori Akhtar-Danesh, Alfonso Iorio, Luciane Cruz Lopes, Gordon H Guyatt
BACKGROUND: Chronic kidney disease-mineral and bone disorder (CKD-MBD), a complication of chronic kidney disease, has been linked to reduced quality and length of life. High serum phosphate levels that result from CKD-MBD require phosphate-lowering agents, also known as phosphate binders. The objective of this systematic review is to compare the effects of available phosphate binders on laboratory outcomes in patients with CKD-MBD. METHODS: Data sources included MEDLINE and EMBASE from January 1996 to April 2016, and the Cochrane Register of Controlled Trials up to April 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28195347/characterization-of-ferroptosis-in-murine-models-of-hemochromatosis
#9
Hao Wang, Peng An, Enjun Xie, Qian Wu, Xuexian Fang, Hong Gao, Zhuzhen Zhang, Yuzhu Li, Xudong Wang, Jiaying Zhang, Guoli Li, Lei Yang, Wei Liu, Junxia Min, Fudi Wang
Ferroptosis is a recently identified iron-dependent form of nonapoptotic cell death implicated in brain, kidney, and heart pathology. However, the biological roles of iron and iron metabolism in ferroptosis remain poorly understood. Here, we studied the functional role of iron and iron metabolism in the pathogenesis of ferroptosis. We found that ferric citrate potently induces ferroptosis in murine primary hepatocytes and bone marrow-derived macrophages. Next, we screened for ferroptosis in mice fed a high-iron diet and in mouse models of hereditary hemochromatosis with iron overload...
August 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28128726/the-safety-of-achieved-iron-stores-and-their-effect-on-iv-iron-and-esa-use-post-hoc-results-from-a-randomized-trial-of-ferric-citrate-as-a-phosphate-binder-in-dialysis%C3%A2
#10
RANDOMIZED CONTROLLED TRIAL
Kausik Umanath, Barbara Greco, Diana I Jalal, Molly McFadden, Mohammed Sika, Mark J Koury, Robert Niecestro, Lawrence G Hunsicker, Tom Greene, Julia B Lewis, Jamie P Dwyer
Iron stores assuring optimal efficacy/safety for erythropoiesis are unknown in the dialysis population. Using multicenter trial data, we related safety profiles, erythropoiesis-stimulating agent (ESA), and intravenous iron dosing to achieved iron stores in 441 subjects randomized 2 : 1 to ferric citrate or active control as their phosphate binder over 52 weeks. Intravenous iron was given at each site's discretion if ferritin ≤ 1,000 ng/mL and transferrin saturation ≤ 30%. Multivariable time-dependent Cox regression jointly related the primary safety outcome (composite of cardiac, infection, gastrointestinal, and hepatobiliary serious adverse events) to moving averages of ferritin and transferrin saturation over the preceding 90 days with covariate adjustment...
March 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28078600/net-budgetary-impact-of-ferric-citrate-as-a-first-line-phosphate-binder-for-the-treatment-of-hyperphosphatemia-a-markov-microsimulation-model
#11
Steven M Brunelli, Scott P Sibbel, David Van Wyck, Amit Sharma, Andrew Hsieh, Glenn M Chertow
Ferric citrate (FC) has demonstrated efficacy as a phosphate binder and reduces the requirements for erythropoiesis-stimulating agents (ESAs) and intravenous (IV) iron in dialysis patients. We developed a net budgetary impact model to evaluate FC vs. other phosphate binders from the vantage of a large dialysis provider. We used a Markov microsimulation model to simulate mutually referential longitudinal effects between serum phosphate and phosphate binder dose; categories of these defined health states. Health states probabilistically determined treatment attendance and utilization of ESA and IV iron...
March 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28011701/use-of-pan-genome-analysis-for-the-identification-of-lineage-specific-genes-of-helicobacter-pylori
#12
COMPARATIVE STUDY
Arnoud H M van Vliet
The human bacterial pathogen Helicobacter pylori has a highly variable genome, with significant allelic and sequence diversity between isolates and even within well-characterised strains, hampering comparative genomics of H. pylori In this study, pan-genome analysis has been used to identify lineage-specific genes of H. pylori A total of 346 H. pylori genomes spanning the hpAfrica1, hpAfrica2, hpAsia2, hpEurope, hspAmerind and hspEAsia multilocus sequence typing (MLST) lineages were searched for genes specifically overrepresented or underrepresented in MLST lineages or associated with the cag pathogenicity island...
January 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/27976867/uniform-fe3o4-nitrogen-doped-mesoporous-carbon-spheres-derived-from-ferric-citrate-bonded-melamine-resin-as-an-efficient-synergistic-catalyst-for-oxygen-reduction
#13
Haitao Wang, Wei Wang, Mengxi Gui, Muhammad Asif, Zhengyun Wang, Yang Yu, Junwu Xiao, Hongfang Liu
Developing a facile strategy to synthesize an efficient and inexpensive catalyst for the oxygen reduction reaction (ORR) is critical to the commercialization of many sustainable energy storage and conversion techniques. Herein, a novel and convenient strategy was presented to prepare Fe3O4 embedded into nitrogen-doped mesoporous carbon spheres (Fe3O4/N-MCS) by the polycondensation between methylolmelamines and ammonium ferric citrate (AFC) and subsequent pyrolysis process. In particular, the polycondensation reaction was completely finished within a very short time (6...
December 23, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27951582/oral-low-dose-ferric-citrate-is-a-useful-iron-source-for-hyperphosphatemic-hemodialysis-patients-a-case-series
#14
Masayuki Tanemoto, Yu Ishimoto, Hisako Saito
BACKGROUND: Randomized trials have demonstrated that a phosphate binder ferric citrate (FeC) increases iron parameters in comparison with other phosphate binders, but the doses for FeC to improve iron stores safely have not been clarified. METHODS: We examined changes of iron parameters and blood hemoglobin (Hb) in 7 iron-deficient hemodialysis (HD) patients taking FeC 750 mg/day as a phosphate binder. RESULTS: The median serum transferrin saturation and ferritin increased from 13% (interquartile range (IQR) 7-18) to 28% (IQR 22-31; p = 0...
2017: Blood Purification
https://www.readbyqxmd.com/read/27862990/effects-of-ferric-citrate-supplementation-on-advanced-glycation-end-products-in-a-rat-model-of-streptozotocin-nicotinamide-induced-diabetes
#15
Kuo-Ching Chao, Seu-Hwa Chen, Chun-Chao Chang, Yu-Chieh Lee, Chi-Mei Wang, Jung-Su Chang
SCOPE: Diabetes is associated with the increased risks of anemia and activation of advanced glycation end products (AGEs) and the receptor for AGEs (RAGE). However, the effects of pharmacological doses of iron supplementation on AGE metabolism are less clear. The aim was to investigate the effect of ferric citrate supplementation on AGE metabolism. METHODS AND RESULTS: Diabetes was induced in overnight starved rats by intraperitoneal injections of 40 mg/kg streptozotocin and 120 mg/kg nicotinamide...
May 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27808258/significant-glial-alterations-in-response-to-iron-loading-in-a-novel-organotypic-hippocampal-slice-culture-model
#16
Sinead Healy, Jill McMahon, Peter Owens, Una FitzGerald
Aberrant iron deposition in the brain is associated with neurodegenerative disorders including Multiple Sclerosis, Alzheimer's disease and Parkinson's disease. To study the collective response to iron loading, we have used hippocampal organotypic slices as a platform to develop a novel ex vivo model of iron accumulation. We demonstrated differential uptake and toxicity of iron after 12 h exposure to 10 μM ferrous ammonium sulphate, ferric citrate or ferrocene. Having established the supremacy of ferrocene in this model, the cultures were then loaded with 0...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27615161/adherence-rates-to-ferric-citrate-as-compared-to-active-control-in-patients-with-end-stage-kidney-disease-on-dialysis
#17
Diana Jalal, Molly McFadden, Jamie P Dwyer, Kausik Umanath, Erwin Aguilar, Yoram Yagil, Barbara Greco, Mohammed Sika, Julia B Lewis, Tom Greene, Simin Goral
INTRODUCTION: Oral phosphate binders are the main stay of treatment of hyperphosphatemia. Adherence rates to ferric citrate, a recently approved phosphate binder, are unknown. METHODS: We conducted a post-hoc analysis to evaluate whether adherence rates were different for ferric citrate vs. active control in 412 subjects with end stage kidney disease (ESKD) who were randomized to ferric citrate vs. active control (sevelamer carbonate and/or calcium acetate). Adherence was defined as percent of actual number of pills taken to total number of pills prescribed...
April 2017: Hemodialysis International
https://www.readbyqxmd.com/read/27406686/fe3o4-carbon-nanosheets-for-all-solid-state-supercapacitor-electrodes
#18
Huailin Fan, Ruiting Niu, Jiaqi Duan, Wei Liu, Wenzhong Shen
Fe3O4@carbon nanosheet composites were synthesized using ammonium ferric citrate as the Fe3O4/carbon precursor and graphene oxide as the structure-directing agent under a hydrothermal process. The surface chemical compositions, pore structures, and morphology of the composite were analyzed and characterized by nitrogen adsorption isotherms, TG analysis, FT-IR, X-ray photoelectron energy spectrum, transmission electron microscopy, and scanning electron microscopy. The composites showed excellent specific capacitance of 586 F/g, 340 F/g at 0...
August 3, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27294920/studies-to-prevent-degradation-of-recombinant-fc-fusion-protein-expressed-in-mammalian-cell-line-and-protein-characterization
#19
Sanjukta Chakrabarti, Colin J Barrow, Rupinder K Kanwar, Venkata Ramana, Jagat R Kanwar
Clipping of recombinant proteins is a major issue in animal cell cultures. A recombinant Fc-fusion protein, VEGFR1(D1-D3)-Fc expressed in CHOK1SV GS-KO cells was observed to be undergoing clippings in lab scale cultures. Partial cleaving of expressed protein initiated early on in cell culture and was observed to increase over time in culture and also on storage. In this study, a few parameters were explored in a bid to inhibit clipping in the fusion protein The effects of culture temperature, duration of culture, the addition of an anti-clumping agent, ferric citrate and use of protease inhibitor cocktail on inhibition of proteolysis of the Fc fusion were studied...
June 9, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27251502/effect-of-a-ferric-citrate-formulation-a-phosphate-binder-on-oxidative-stress-in-chronic-kidney-diseases-mineral-and-bone-disorder-patients-receiving-hemodialysis-a-pilot-study
#20
Motoko Tanaka, Shigeyuki Miyamura, Tadashi Imafuku, Yuna Tominaga, Hitoshi Maeda, Makoto Anraku, Keishi Yamasaki, Daisuke Kadowaki, Yu Ishima, Hiroshi Watanabe, Tomoko Okuda, Kazuko Itoh, Kazutaka Matsushita, Masafumi Fukagawa, Masaki Otagiri, Toru Maruyama
A ferric citrate formulation for treating hyperphosphatemia is a new therapeutic that not only suppresses the accumulation of phosphorus in patients with chronic kidney disease-mineral bone disorders (CKD-MBD), but also ameliorates anemia caused by iron deficiency. In contrast, it has been demonstrated that intravenous iron injection markedly increases oxidative stress. This study was designed to investigate the effect of a ferric citrate formulation on oxidative stress in CKD-MBD patients receiving hemodialysis therapy...
2016: Biological & Pharmaceutical Bulletin
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