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"Ferric citrate"

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https://www.readbyqxmd.com/read/27862990/effects-of-ferric-citrate-supplementation-on-advanced-glycation-end-products-in-a-rat-model-of-streptozotocin-nicotinamide-induced-diabetes
#1
Kuo-Ching Chao, Seu-Hwa Chen, Chun-Chao Chang, Yu-Chieh Lee, Chi-Mei Wang, Jung-Su Chang
SCOPE: Diabetes is associated with increased risks of anemia and activation of advanced glycation end products (AGEs) and the receptor for AGEs (RAGE). However, the effects of pharmacological doses of iron supplementation on AGE metabolism are less clear. The aim was to investigate the effect of ferric citrate supplementation on AGE metabolism. METHODS AND RESULTS: Diabetes was induced in overnight starved rats by intraperitoneal injections of 40 mg/kg streptozotocin and 120 mg/kg nicotinamide...
November 10, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27808258/significant-glial-alterations-in-response-to-iron-loading-in-a-novel-organotypic-hippocampal-slice-culture-model
#2
Sinead Healy, Jill McMahon, Peter Owens, Una FitzGerald
Aberrant iron deposition in the brain is associated with neurodegenerative disorders including Multiple Sclerosis, Alzheimer's disease and Parkinson's disease. To study the collective response to iron loading, we have used hippocampal organotypic slices as a platform to develop a novel ex vivo model of iron accumulation. We demonstrated differential uptake and toxicity of iron after 12 h exposure to 10 μM ferrous ammonium sulphate, ferric citrate or ferrocene. Having established the supremacy of ferrocene in this model, the cultures were then loaded with 0...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27615161/adherence-rates-to-ferric-citrate-as-compared-to-active-control-in-patients-with-end-stage-kidney-disease-on-dialysis
#3
Diana Jalal, Molly McFadden, Jamie P Dwyer, Kausik Umanath, Erwin Aguilar, Yoram Yagil, Barbara Greco, Mohammed Sika, Julia B Lewis, Tom Greene, Simin Goral
Introduction Oral phosphate binders are the main stay of treatment of hyperphosphatemia. Adherence rates to ferric citrate, a recently approved phosphate binder, are unknown. Methods We conducted a post-hoc analysis to evaluate whether adherence rates were different for ferric citrate vs. active control in 412 subjects with end stage kidney disease (ESKD) who were randomized to ferric citrate vs. active control (sevelamer carbonate and/or calcium acetate). Adherence was defined as percent of actual number of pills taken to total number of pills prescribed...
September 12, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27406686/fe3o4-carbon-nanosheets-for-all-solid-state-supercapacitor-electrodes
#4
Huailin Fan, Ruiting Niu, Jiaqi Duan, Wei Liu, Wenzhong Shen
Fe3O4@carbon nanosheet composites were synthesized using ammonium ferric citrate as the Fe3O4/carbon precursor and graphene oxide as the structure-directing agent under a hydrothermal process. The surface chemical compositions, pore structures, and morphology of the composite were analyzed and characterized by nitrogen adsorption isotherms, TG analysis, FT-IR, X-ray photoelectron energy spectrum, transmission electron microscopy, and scanning electron microscopy. The composites showed excellent specific capacitance of 586 F/g, 340 F/g at 0...
August 3, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27294920/studies-to-prevent-degradation-of-recombinant-fc-fusion-protein-expressed-in-mammalian-cell-line-and-protein-characterization
#5
Sanjukta Chakrabarti, Colin J Barrow, Rupinder K Kanwar, Venkata Ramana, Jagat R Kanwar
Clipping of recombinant proteins is a major issue in animal cell cultures. A recombinant Fc-fusion protein, VEGFR1(D1-D3)-Fc expressed in CHOK1SV GS-KO cells was observed to be undergoing clippings in lab scale cultures. Partial cleaving of expressed protein initiated early on in cell culture and was observed to increase over time in culture and also on storage. In this study, a few parameters were explored in a bid to inhibit clipping in the fusion protein The effects of culture temperature, duration of culture, the addition of an anti-clumping agent, ferric citrate and use of protease inhibitor cocktail on inhibition of proteolysis of the Fc fusion were studied...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27251502/effect-of-a-ferric-citrate-formulation-a-phosphate-binder-on-oxidative-stress-in-chronic-kidney-diseases-mineral-and-bone-disorder-patients-receiving-hemodialysis-a-pilot-study
#6
Motoko Tanaka, Shigeyuki Miyamura, Tadashi Imafuku, Yuna Tominaga, Hitoshi Maeda, Makoto Anraku, Keishi Yamasaki, Daisuke Kadowaki, Yu Ishima, Hiroshi Watanabe, Tomoko Okuda, Kazuko Itoh, Kazutaka Matsushita, Masafumi Fukagawa, Masaki Otagiri, Toru Maruyama
A ferric citrate formulation for treating hyperphosphatemia is a new therapeutic that not only suppresses the accumulation of phosphorus in patients with chronic kidney disease-mineral bone disorders (CKD-MBD), but also ameliorates anemia caused by iron deficiency. In contrast, it has been demonstrated that intravenous iron injection markedly increases oxidative stress. This study was designed to investigate the effect of a ferric citrate formulation on oxidative stress in CKD-MBD patients receiving hemodialysis therapy...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27236135/ferric-citrate-in-patients-with-chronic-kidney-disease
#7
REVIEW
Geoffrey A Block
Ferric citrate (FC) is an iron-containing phosphate binder that has been shown to effectively decrease serum phosphate, increase hemoglobin, and replete iron stores in patients with chronic kidney disease. Intestinal absorption of iron from FC results in increases in serum iron, ferritin, and transferrin saturation, effects that occur over 12 to 24 weeks and subsequently appear to plateau. As a result, use of erythropoiesis-stimulating agents and intravenous iron is reduced significantly and in clinical trials in patients receiving hemodialysis, the majority of subjects were able to discontinue intravenous iron use completely...
March 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27236132/safety-issues-in-iron-treatment-in-ckd
#8
REVIEW
Nosratola D Vaziri
Intravenous iron products are essential for the treatment of anemia in end-stage renal disease patients maintained on hemodialysis. Although proper use of these compounds is necessary for the prevention of iron deficiency, their indiscriminate use could potentially cause insidious adverse consequences. Iron overload can intensify the chronic kidney disease-associated oxidative stress, inflammation, and cardiovascular disease; increase the risk of infections; worsen the severity of type 2 diabetes; and exacerbate neurologic and cognitive dysfunction...
March 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27225457/calculibacillus-koreensis-gen-nov-sp-nov-an-anaerobic-fe-iii-reducing-bacterium-isolated-from-sediment-of-mine-tailings
#9
Ui-Gi Min, So-Jeong Kim, Heeji Hong, Song-Gun Kim, Joo-Han Gwak, Man-Young Jung, Jong-Geol Kim, Jeong-Geol Na, Sung-Keun Rhee
A strictly anaerobic bacterium, strain B5(T), was isolated from sediment of an abandoned coal mine in Taebaek, Republic of Korea. Cells of strain B5(T) were non-spore-forming, straight, Gram-positive rods. The optimum pH and temperature for growth were pH 7.0 and 30°C, respectively, while the strain was able to grow within pH and temperature ranges of 5.5-7.5 and 25-45°C, respectively. Growth of strain B5(T) was observed at NaCl concentrations of 0 to 6.0% (w/v) with an optimum at 3.0-4.0% (w/v). The polar lipids consisted of phosphatidylethanolamine, phosphatidylglycerol, an unknown phospholipid and three unknown polar lipids...
June 2016: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/27194339/pathogenic-upregulation-of-glial-lipocalin-2-in-the-parkinsonian-dopaminergic-system
#10
Byung-Wook Kim, Kyoung Hoon Jeong, Jae-Hong Kim, Myungwon Jin, Jong-Heon Kim, Maan-Gee Lee, Dong-Kug Choi, So-Yoon Won, Catriona McLean, Min-Tae Jeon, Ho-Won Lee, Sang Ryong Kim, Kyoungho Suk
UNLABELLED: Lipocalin-2 (LCN2) is a member of the highly heterogeneous secretory protein family of lipocalins and increases in its levels can contribute to neurodegeneration in the adult brain. However, there are no reports on the role of LCN2 in Parkinson's disease (PD). Here, we report for the first time that LCN2 expression is increased in the substantia nigra (SN) of patients with PD. In mouse brains, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment for a neurotoxin model of PD significantly upregulated LCN2 expression, mainly in reactive astrocytes in both the SN and striatum...
May 18, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27178230/functional-analysis-of-an-feob-mutant-in-clostridium-perfringens-strain-13
#11
Milena M Awad, Jackie K Cheung, Joanne E Tan, Alastair G McEwan, Dena Lyras, Julian I Rood
Bacterial pathogens have adopted numerous mechanisms for acquiring iron from host proteins during an infection, including the direct acquisition of ferric iron from heme-associated proteins or from iron-scavenging siderophores. Ferric iron then is transported into the cytosol, where it can be utilized by the bacterial pathogen. Under anaerobic conditions bacteria can also transport ferrous iron using the transmembrane complex FeoAB, but little is known about iron transport systems in anaerobic bacteria such as the pathogenic clostridia...
May 10, 2016: Anaerobe
https://www.readbyqxmd.com/read/27153768/we-give-too-much-intravenous-iron
#12
Jamie P Dwyer
Dialysis patients have absolute and functional iron deficiencies. Traditionally, oral iron preparations have been insufficient to maintain iron stores to support erythropoiesis, especially in the setting of the ubiquitous use of erythropoiesis-stimulating agents. This has led to the widespread adoption of intravenous iron protocols designed to maintain iron stores at levels that are much higher than for patients not on dialysis. These protocols are often developed by dialysis providers and may be largely independent of the treating nephrologist...
July 2016: Seminars in Dialysis
https://www.readbyqxmd.com/read/27043055/evaluation-of-ferric-oxide-and-ferric-citrate-for-their-effects-on-fermentation-production-of-sulfide-and-methane-and-abundance-of-select-microbial-populations-using-in-vitro-rumen-cultures
#13
Hao Wu, Qingxiang Meng, Zhongtang Yu
This study systematically evaluated the effect of ferric iron on sulfate reduction to sulfide, feed digestion and fermentation, methane production, and populations of select ruminal microbes using in vitro rumen cultures. Ferric oxide (Fe2O3) and ferric citrate (C6H5FeO7) at six concentrations (0, 25, 50, 100, 150, and 200mg/L as Fe(3+)) were tested. Ferric iron decreased production of both H2S gas in culture headspace (up to 71.9%) and aqueous sulfide (up to 80.8%), without adversely affecting other fermentation parameters, with ferric citrate being more effective than ferric oxide...
July 2016: Bioresource Technology
https://www.readbyqxmd.com/read/26929139/evaluating-the-effectiveness-of-transferrin-receptor-1-tfr1-as-a-magnetic-resonance-reporter-gene
#14
Sofia M Pereira, Anne Herrmann, Diana Moss, Harish Poptani, Steve R Williams, Patricia Murray, Arthur Taylor
Magnetic resonance (MR) reporter genes have the potential for tracking the biodistribution and fate of cells in vivo, thus allowing the safety, efficacy and mechanisms of action of cell-based therapies to be comprehensively assessed. In this study, we evaluate the effectiveness of the iron importer transferrin receptor-1 (TfR1) as an MR reporter gene in the model cell line CHO-K1. Overexpression of the TfR1 transgene led to a reduction in the levels of endogenous TfR1 mRNA, but to a 60-fold increase in total TfR1 protein levels...
May 2016: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/26813504/-phosphate-metabolism-and-iron-deficiency
#15
REVIEW
Keitaro Yokoyama
Autosomal dominant hypophosphatemic rickets(ADHR)is caused by gain-of-function mutations in FGF23 that prevent its proteolytic cleavage. Fibroblast growth factor 23(FGF23)is a hormone that inhibits renal phosphate reabsorption and 1,25-dihydroxyvitamin D biosynthesis. Low iron status plays a role in the pathophysiology of ADHR. Iron deficiency is an environmental trigger that stimulates FGF23 expression and hypophosphatemia in ADHR. It was reported that FGF23 elevation in patients with CKD, who are often iron deficient...
February 2016: Clinical Calcium
https://www.readbyqxmd.com/read/26800972/phosphate-binders-in-chronic-kidney-disease-a-systematic-review-of-recent-data
#16
REVIEW
Jürgen Floege
Hyperphosphatemia is common in chronic kidney disease (CKD) and is treated by dietary measures, dialysis techniques and/or phosphate binders. For the present review PubMed was searched for new publications on phosphate binders appearing between January 2010 and October 2015. This review summarizes the latest information on non-pharmacological measures and their problems in lowering phosphate in CKD patients, effects of phosphate binders on morbidity and mortality, adherence to phosphate binder therapy as well as new information on specific aspects of the various phosphate binders on the market: calcium acetate, calcium carbonate, magnesium-containing phosphate binders, polymeric phosphate binders (sevelamer, bixalomer, colestilan), lanthanum carbonate, ferric citrate, sucroferric oxyhydroxide, aluminum-containing phosphate binders, and new compounds in development...
June 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/26796551/visual-detection-technique-for-efficient-screening-and-isolation-of-salmonella-based-on-a-novel-enrichment-assay-using-chromatography-membrane
#17
F Tang, Y Xiong, H Zhang, K Wu, Y Xiang, J-B Shao, H-W Ai, Y-P Xiang, X-L Zheng, J-R Lv, H Sun, L-S Bao, Z Zhang, H-B Hu, J-Y Zhang, L Chen, J Lu, W-Y Liu, H Mei, Y Ma, C-F Xu, A-Y Fang, M Gu, C-Y Xu, Y Chen, Z Chen, Z-Y Sun
To detect Salmonella more efficiently and isolate strains more easily, a novel and simple detection method that uses an enrichment assay and two chromogenic reactions on a chromatography membrane was developed. Grade 3 chromatography paper is used as functionalized solid phase support (SPS), which contains specially optimized medium. One reaction for screening is based on the sulfate-reducing capacity of Salmonella. Hydrogen sulfide (H2S) generated by Salmonella reacts with ammonium ferric citrate to produce black colored ferrous sulfide...
March 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/26779139/microbial-metabolism-shifts-towards-an-adverse-profile-with-supplementary-iron-in-the-tim-2-in-vitro-model-of-the-human-colon
#18
Guus A M Kortman, Bas E Dutilh, Annet J H Maathuis, Udo F Engelke, Jos Boekhorst, Kevin P Keegan, Fiona G G Nielsen, Jason Betley, Jacqueline C Weir, Zoya Kingsbury, Leo A J Kluijtmans, Dorine W Swinkels, Koen Venema, Harold Tjalsma
Oral iron administration in African children can increase the risk for infections. However, it remains unclear to what extent supplementary iron affects the intestinal microbiome. We here explored the impact of iron preparations on microbial growth and metabolism in the well-controlled TNO's in vitro model of the large intestine (TIM-2). The model was inoculated with a human microbiota, without supplementary iron, or with 50 or 250 μmol/L ferrous sulfate, 50 or 250 μmol/L ferric citrate, or 50 μmol/L hemin...
2015: Frontiers in Microbiology
https://www.readbyqxmd.com/read/26761712/comparison-of-phosphate-binding-capacities-of-pa21-a-novel-phosphate-binder-with-those-of-other-phosphate-binders-in-vitro-and-in-vivo
#19
A Yaguchi, S Yonekubo, I Maruyama, S Tatemichi, K Maruyama, M Kobayashi
PURPOSE: The phosphate binding capacity of PA21, a novel phosphate binder, was compared with those of other phosphate binders in vitro and in vivo. METHODS: 1) For in vitro studies, PA21, sevelamer hydrochloride, lanthanum carbonate hydrate, calcium carbonate, and ferric citrate hydrate were incubated with a phosphate solution at 37°C for 2 h. Phosphate binding capacity was assessed at simulated gastrointestinal tract pH levels of 2, 5, and 8 for estimation of clinical effects, and the quantity of phosphate adsorbed by each phosphate binder was determined...
May 2016: Drug Research
https://www.readbyqxmd.com/read/26760282/development-of-a-low-serum-medium-for-the-production-of-monoclonal-antibody-against-congenital-adrenal-hyperplasia-by-hybridoma-culture
#20
Gek Kee Chua
Statistically designed experiments were used in developing a low-serum medium for the production of a diagnostic monoclonal antibody against congenital adrenal hyperplasia using hybridoma 192. A two-level half-fractional factorial design was used for screening six components (Minimum Essential Medium Eagle amino acids, 2-mercaptoethanol, ethanolamine, ferric citrate, zinc sulfate, and sodium selenite). The experimental design was then augmented to central composite design. The basal Dulbecco's modified Eagle's medium (DMEM; containing 4 mM L-glutamine, 1% antibiotic-antimycotic agent) supplemented with 0...
October 2, 2016: Preparative Biochemistry & Biotechnology
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