Ziyi Zhao, Jiandong Wang, Weimin Kong, Ziwei Fang, Michael Coleman, Ginger Milne, Wesley C Burkett, Meredith A Newton, Douglas Lee, Beor Deng, Xiaochang Shen, Hongyan Suo, Wenchuan Sun, Stephen Hursting, Chunxiao Zhou, Victoria L Bae-Jump
OBJECTIVE: Overweight/obesity is the strongest risk factor for endometrial cancer (EC), and weight management can reduce that risk and improve survival. We aimed to establish the differential abilities of intermittent energy restriction (IER) and low-fat diet (LFD), alone and in combination with paclitaxel, to reverse the procancer effects of high-fat diet (HFD)-induced obesity in a mouse model of EC. METHODS: Lkb1 fl/fl p53 fl/fl mice were fed high-fat diet (HFD) or LFD to generate obese and lean phenotypes, respectively...
February 7, 2024: bioRxiv