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https://www.readbyqxmd.com/read/29448090/uhplc-qtof-ms-analysis-of-bioactive-constituents-from-two-romanian-goji-lycium-barbarum-l-berries-cultivars-and-their-antioxidant-enzyme-inhibitory-and-real-time-cytotoxicological-evaluation
#1
Andrei Mocan, Cadmiel Moldovan, Gökhan Zengin, Onur Bender, Marcello Locatelli, Mario Simirgiotis, Arzu Atalay, Dan C Vodnar, Sascha Rohn, Gianina Crișan
Goji (Lycium barbarum L.) berries are emphasized as healthy food or are used widely as dietary supplements. In the present study, the antioxidant and enzyme inhibitory activities of berries extracts from two selected Romanian cultivars (cv. Erma and cv. Biglifeberry) have been evaluated. UHPLC-QTOF-MS analysis results revealed the presence of vitamin C and related compounds, phenolic acids, flavonoids, fatty acids (oxylipins), and spermidine derivatives. In particular, cv. Erma showed a strong tyrosinase-inhibitory effect, whereas cv...
February 12, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29422909/depletion-of-arabidopsis-acyl-coa-binding-protein3-affects-fatty-acid-composition-in-the-phloem
#2
Tai-Hua Hu, Shiu-Cheung Lung, Zi-Wei Ye, Mee-Len Chye
Oxylipins are crucial components in plant wound responses that are mobilised via the plant vasculature. Previous studies have shown that the overexpression of an Arabidopsis acyl-CoA-binding protein, AtACBP3, led to an accumulation of oxylipin-containing galactolipids, and AtACBP3pro::BETA-GLUCURONIDASE (GUS) was expressed in the phloem of transgenic Arabidopsis. To investigate the role of AtACBP3 in the phloem, reverse transcription-polymerase chain reaction and western blot analysis of phloem exudates from the acbp3 mutant and wild type revealed that the AtACBP3 protein, but not its mRNA, was detected in the phloem sap...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29413356/abnormal-lipoprotein-oxylipins-in-metabolic-syndrome-and-partial-correction-by-omega-3-fatty-acids
#3
Gregory C Shearer, Kamil Borkowski, Susan L Puumala, William S Harris, Theresa L Pedersen, John W Newman
Metabolic syndrome (MetSyn) is characterized by chronic inflammation which mediates the associated high risk for cardiovascular and other diseases. Oxylipins are a superclass of lipid mediators with potent bioactivities in inflammation, vascular biology, and more. While their role as locally produced agents is appreciated, most oxylipins in plasma are found in lipoproteins suggesting defective regulation of inflammation could be mediated by the elevated VLDL and low HDL levels characteristic of MetSyn. Our objective was to compare the oxylipin composition of VLDL, LDL, and HDL in 14 optimally healthy individuals and 31 MetSyn patients, and then to determine the effects of treating MetSyn subjects with 4g/day of prescription omega-3 fatty acids (P-OM3) on lipoprotein oxylipin profiles...
January 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29407524/metabolic-inflammatory-vascular-comorbidity-in-psychiatric-disorders-soluble-epoxide-hydrolase-seh-as-a-possible-new-target
#4
REVIEW
W Swardfager, M Hennebelle, D Yu, B D Hammock, A J Levitt, K Hashimoto, A Y Taha
The common and severe psychiatric disorders, including major depressive disorder (MDD) and bipolar disorder (BD), are associated with inflammation, oxidative stress and changes in peripheral and brain lipid metabolism. Those pathways are implicated in the premature development of vascular and metabolic comorbidities, which account for considerable morbidity and mortality, including increased dementia risk. During endoplasmic reticulum stress, the soluble epoxide hydrolase (sEH) enzyme converts anti-inflammatory fatty acid epoxides generated by cytochrome p450 enzymes into their corresponding and generally less anti-inflammatory, or even pro-inflammatory, diols, slowing the resolution of inflammation...
February 2, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29385065/breast-milk-lipidome-is-associated-with-early-growth-trajectory-in-preterm-infants
#5
Marie-Cécile Alexandre-Gouabau, Thomas Moyon, Véronique Cariou, Jean-Philippe Antignac, El Mostafa Qannari, Mikaël Croyal, Mohamed Soumah, Yann Guitton, Agnès David-Sochard, Hélène Billard, Arnaud Legrand, Cécile Boscher, Dominique Darmaun, Jean-Christophe Rozé, Clair-Yves Boquien
Human milk is recommended for feeding preterm infants. The current pilot study aims to determine whether breast-milk lipidome had any impact on the early growth-pattern of preterm infants fed their own mother's milk. A prospective-monocentric-observational birth-cohort was established, enrolling 138 preterm infants, who received their own mother's breast-milk throughout hospital stay. All infants were ranked according to the change in weight Z-score between birth and hospital discharge. Then, we selected infants who experienced "slower" (n = 15, -1...
January 31, 2018: Nutrients
https://www.readbyqxmd.com/read/29343538/impact-of-dietary-%C3%AF-3-polyunsaturated-fatty-acid-supplementation-on-brown-and-brite-adipocyte-function
#6
Rayane A Ghandour, Cecilia Colson, Maude Giroud, Stefanie Maurer, Samah Rekima, Gerard P Ailhaud, Martin Klingenspor, Ez-Zoubir Amri, Didier F Pisani
The recent characterization of functional brown adipose tissue (BAT) in adult humans has opened new perspectives for regulation of energy expenditure with respect to obesity and diabetes. Furthermore, dietary recommendations have taken into account the insufficient dietary intake of ω3 polyunsaturated fatty acids (PUFA) and the concomitant excessive intake of ω6 PUFA associated with the occurrence of overweight/obesity. We aimed to study whether ω3 PUFAs could play a role in the recruitment and function of energy-dissipating brown/brite adipocytes...
January 17, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29330904/testing-a-chemical-series-inspired-by-plant-stress-oxylipin-signaling-agents-for-herbicide-safening-activity
#7
Melissa Brazier-Hicks, Kathryn M Knight, Jonathan D Sellars, Patrick G Steel, Robert Edwards
BACKGROUND: Herbicide safening in cereals is linked to a rapid xenobiotic response (XR), involving the induction of glutathione transferases (GSTs). The XR is also invoked by oxidized fatty acids (oxylipins) released during plant stress, suggesting a link between these signaling agents and safening. To examine this relationship, a series of compounds modelled on the oxylipins 12-oxophytodienoic acid and phytoprostane 1, varying in lipophilicity and electrophilicity were synthesized. Compounds were then tested for their ability to invoke the XR in Arabidopsis and protect rice seedlings exposed to the herbicide pretilachlor, as compared with the safener fenclorim...
January 13, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29329333/wide-range-screening-of-anti-inflammatory-compounds-in-tomato-using-lc-ms-and-elucidating-the-mechanism-of-their-functions
#8
Shinsuke Mohri, Haruya Takahashi, Maiko Sakai, Shingo Takahashi, Naoko Waki, Koichi Aizawa, Hiroyuki Suganuma, Takeshi Ara, Yasuki Matsumura, Daisuke Shibata, Tsuyoshi Goto, Teruo Kawada
Obesity-induced chronic inflammation is a key factor in type 2 diabetes. A vicious cycle involving pro-inflammatory mediators between adipocytes and macrophages is a common cause of chronic inflammation in the adipose tissue. Tomato is one of the most popular vegetables and is associated with a reduced risk of diabetes. However, the molecular mechanism underlying the effect of tomato on diabetes is unclear. In this study, we focused on anti-inflammatory compounds in tomato. We found that the extract of tomato reduced plasma glucose and inflammatory markers in mice...
2018: PloS One
https://www.readbyqxmd.com/read/29316682/effect-of-omega-3-fatty-acid-supplementation-on-oxylipins-in-a-routine-clinical-setting
#9
Christoph Schmöcker, Ingrid W Zhang, Stefanie Kiesler, Ursula Kassner, Annika I Ostermann, Elisabeth Steinhagen-Thiessen, Nils H Schebb, Karsten-H Weylandt
Omega-6 polyunsaturated fatty acid (n-6 PUFA) is the predominant polyunsaturated fatty acid (PUFA), especially in Western diet. A high omega-6/omega-3 ratio in Western diets is implicated in the development of cardiovascular diseases and inflammatory processes. Studies in animal models and in humans have demonstrated beneficial effects of omega-3 PUFA (n-3 PUFA) in a variety of diseases, including cardiac arrhythmias and inflammatory diseases, as well as breast and colon cancer. The molecular mechanisms underlying the effects of n-3 PUFA are still not well understood...
January 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29301345/eicosanoid-diversity-of-stony-corals
#10
Helike Lõhelaid, Nigulas Samel
Oxylipins are well-established lipid mediators in plants and animals. In mammals, arachidonic acid (AA)-derived eicosanoids control inflammation, fever, blood coagulation, pain perception and labor, and, accordingly, are used as drugs, while lipoxygenases (LOX), as well as cyclooxygenases (COX) serve as therapeutic targets for drug development. In soft corals, eicosanoids are synthesized on demand from AA by LOX, COX, and catalase-related allene oxide synthase-lipoxygenase (cAOS-LOX) and hydroperoxide lyase-lipoxygenase (cHPL-LOX) fusion proteins...
January 3, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29234336/evolution-and-expansion-of-the-prokaryote-like-lipoxygenase-family-in-the-brown-alga-saccharina-japonica
#11
Linhong Teng, Wentao Han, Xiao Fan, Dong Xu, Xiaowen Zhang, Simon M Dittami, Naihao Ye
Lipoxygenase (LOX) plays important roles in fatty acid oxidation and lipid mediator biosynthesis. In this study, we give first insights into brown algal LOX evolution. Whole genome searches revealed four, three, and eleven LOXs in Ectocarpus siliculosus, Cladosiphon okamuranus, and Saccharina japonica, respectively. In phylogenetic analyses, LOXs from brown algae form a robust clade with those from prokaryotes, suggesting an ancestral origin and slow evolution. Brown algal LOXs were divided into two clades, C1 and C2 in a phylogenetic tree...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29232862/effect-of-oxylipins-terpenoid-precursors-and-wounding-on-soft-corals-secondary-metabolism-as-analyzed-via-uplc-ms-and-chemometrics
#12
Mohamed A Farag, Hildegard Westphal, Tarek F Eissa, Ludger A Wessjohann, Achim Meyer
The effect of three oxylipin analogues, a terpenoid intermediate and wounding on the secondary metabolism of the soft corals Sarcophyton glaucum and Lobophyton pauciflorum was assessed. Examined oxylipins included prostaglandin (PG-E1), methyl jasmonate (MeJA), and arachidonic acid (AA) in addition to the diterpene precursor geranylgeranylpyrophosphate (GGP). Post-elicitation, metabolites were extracted from coral heads and analyzed via UPLC-MS followed by multivariate data analyses. Both supervised and unsupervised data analyses were used for sample classification...
December 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29231216/aronia-citrus-juice-polyphenol-rich-juice-intake-and-elite-triathlon-training-a-lipidomic-approach-using-representative-oxylipins-in-urine
#13
Libia Alejandra García-Flores, Sonia Medina, Cristina Gómez, Craig E Wheelock, Roberto Cejuela, José Miguel Martínez-Sanz, Camille Oger, Jean-Marie Galano, Thierry Durand, Álvaro Hernández-Sáez, Federico Ferreres, Ángel Gil-Izquierdo
In the present study, we examined whether particular urinary oxylipins (isoprostanes (IsoPs), leukotrienes (LTs), prostaglandins (PGs), and thromboxanes (TXs)) in 16 elite triathletes could alter during 145 days of training. Within this time span, 45 days were dedicated to examining the effects of the intake of a beverage rich in polyphenols (one serving: 200 mL per day) supplemented in their diet. The beverage was a mixture of citrus juice (95%) and Aronia melanocarpa juice (5%) (ACJ). Fifty-two oxylipins were analyzed in the urine...
December 12, 2017: Food & Function
https://www.readbyqxmd.com/read/29207281/dark-chilling-and-subsequent-photo-activation-modulate-expression-and-induce-reversible-association-of-chloroplast-lipoxygenase-with-thylakoid-membrane-in-runner-bean-phaseolus-coccineus-l
#14
Radosław Mazur, Joanna Trzcinska-Danielewicz, Piotr Kozlowski, Łucja Kowalewska, Izabela Rumak, Brian J Shiell, Agnieszka Mostowska, Wojtek P Michalski, Maciej Garstka
Lipoxygenases (LOXs) are non-haem iron-containing dioxygenases that catalyse oxygenation of polyunsaturated fatty acids. This reaction is the first step in biosynthesis of oxylipins, which play important and diverse roles in stress response. In this study, we identified four LOX genes (PcLOXA, B, C, D) in chilling-sensitive runner bean (Phaseolus coccineus L.) plant and analyzed their expression patterns during long term dark-chilling (4 °C) stress and during day/night (21ºC/4 °C) temperature fluctuations...
November 26, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29195136/oxidized-ldl-triggers-changes-in-oxidative-stress-and-inflammatory-biomarkers-in-human-macrophages
#15
Oscar J Lara-Guzmán, Ángel Gil-Izquierdo, Sonia Medina, Edison Osorio, Rafael Álvarez-Quintero, Natalia Zuluaga, Camille Oger, Jean-Marie Galano, Thierry Durand, Katalina Muñoz-Durango
Oxidized low-density lipoprotein (oxLDL) is a well-recognized proatherogenic particle that functions in atherosclerosis. In this study, we established conditions to generate human oxLDL, characterized according to the grade of lipid and protein oxidation, particle size and oxylipin content. The induction effect of the cellular proatherogenic response was assessed in foam cells by using an oxLDL-macrophage interaction model. Uptake of oxLDL, reactive oxygen species production and expression of oxLDL receptors (CD36, SR-A and LOX-1) were significantly increased in THP-1 macrophages...
November 22, 2017: Redox Biology
https://www.readbyqxmd.com/read/29194658/mycorrhizal-tomato-plants-fine-tunes-the-growth-defence-balance-upon-n-depleted-root-environments
#16
P Sánchez-Bel, N Sanmartín, V Pastor, D Mateu, M Cerezo, A Vidal-Albalat, J Pastor-Fernández, M J Pozo, V Flors
In low nutritive environments, the uptake of N by Arbuscular Mycorrhizal Fungi may confer competitive advantages for the host. The present study aims to understand how mycorrhizal tomato plants perceive and then prepare for a N depletion in the root environment. Plants colonized by Rhizophagus irregularis displayed improved responses to a lack of N than non-mycorrhizal plants. These responses were accomplished by a complex metabolic and transcriptional rearrangement that mostly affected the gibberellic acid and jasmonic acid pathways involvingDELLA and JAZ1 genes, which were responsive to changes in the C/N imbalance of the plant...
November 30, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29188048/effects-of-cooking-techniques-on-fatty-acid-and-oxylipin-content-of-farmed-rainbow-trout-oncorhynchus-mykiss
#17
Katrina Flaskerud, Michael Bukowski, Mikhail Golovko, LuAnn Johnson, Stephen Brose, Ashrifa Ali, Beth Cleveland, Matthew Picklo, Susan Raatz
The aim of this study was to investigate the effect of various cooking techniques on the fatty acid and oxylipin content of farmed rainbow trout. Rainbow trout is an excellent source of long-chain omega-3 (n-3) polyunsaturated fatty acids (PUFA) which have beneficial health effects. Fillets of 2-year-old farmed rainbow trout were baked, broiled, microwaved, or pan-fried in corn (CO), canola (CaO), peanut (PO), or high oleic sunflower oil (HOSO). Fatty acids and oxidized lipids were extracted from these samples and their respective raw fillet samples...
November 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/29166128/the-oxylipin-pathways-biochemistry-and-function
#18
Claus Wasternack, Ivo Feussner
Plant oxylipins form a constantly growing group of signaling molecules that comprise oxygenated fatty acids and metabolites derived therefrom. In the last decade, the understanding of biosynthesis, metabolism, and action of oxylipins, especially jasmonates, has dramatically improved. Additional mechanistic insights into the action of enzymes and insights into signaling pathways have been deepened for jasmonates. For other oxylipins, such as the hydroxy fatty acids, individual signaling properties and cross talk between different oxylipins or even with additional phytohormones have recently been described...
November 20, 2017: Annual Review of Plant Biology
https://www.readbyqxmd.com/read/29129670/microalgae-derived-oxylipins-decrease-inflammatory-mediators-by-regulating-the-subcellular-location-of-nf%C3%AE%C2%BAb-and-ppar-%C3%AE
#19
Javier Ávila-Román, Elena Talero, Carolina de Los Reyes, Sofía García-Mauriño, Virginia Motilva
Oxylipins (OXLs) are bioactive molecules generated by the oxidation of fatty acids that promote the resolution of acute inflammation and prevent chronic inflammatory processes through molecular mechanisms that are not well known. We have previously reported the anti-inflammatory activity of microalgae-derived OXLs and OXL-containing biomass in two inflammatory bowel disease (IBD) models: 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced acute colitis and TNBS-induced recurrent colitis. In this study, we examined the in vitro anti-inflammatory mechanism of action of the most abundant OXLs isolated from Chlamydomonas debaryana (13S-HOTE and 13S-HODE) and Nannochloropsis gaditana (15S-HEPE)...
November 9, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29117227/kojic-acid-mediated-damage-responses-induce-mycelial-regeneration-in-the-basidiomycete-hypsizygus-marmoreus
#20
Jinjing Zhang, Hui Chen, Mingjie Chen, Hong Wang, Qian Wang, Xiaoxia Song, Haibo Hao, Zhiyong Feng
Mechanical damage can induce fruiting body production in fungi. In this study, the antioxidant kojic acid (KA) was found to enhance injured mycelial regeneration and increase fruiting body production in Hypsizygus marmoreus. KA reduced the level of reactive oxygen species (ROS), which are harmful to mycelia when excessively generated by mechanical damage. Moreover, KA increased catalase and superoxide dismutase activities and glutathione and ascorbic acid contents by up-regulating antioxidant gene expression...
2017: PloS One
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