keyword
MENU ▼
Read by QxMD icon Read
search

oxylipins

keyword
https://www.readbyqxmd.com/read/27916835/synthesis-and-functions-of-jasmonates-in-maize
#1
REVIEW
Eli J Borrego, Michael V Kolomiets
Of the over 600 oxylipins present in all plants, the phytohormone jasmonic acid (JA) remains the best understood in terms of its biosynthesis, function and signaling. Much like their eicosanoid analogues in mammalian system, evidence is growing for the role of the other oxylipins in diverse physiological processes. JA serves as the model plant oxylipin species and regulates defense and development. For several decades, the biology of JA has been characterized in a few dicot species, yet the function of JA in monocots has only recently begun to be elucidated...
November 29, 2016: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/27898730/plasma-lipid-profiling-of-patients-with-chronic-ocular-complications-caused-by-stevens-johnson-syndrome-toxic-epidermal-necrolysis
#2
Kosuke Saito, Mayumi Ueta, Keiko Maekawa, Chie Sotozono, Shigeru Kinoshita, Yoshiro Saito
Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are drug-induced acute inflammatory vesiculobullous reactions of the skin and mucous membranes, including the ocular surface. Even after recovery from skin symptoms, some SJS/TEN patients continue to suffer with severe ocular complications (SOCs). Therefore, this study aims to understand the pathophysiology of chronic SOCs. Because plasma lipid profiling has emerged as a useful tool to understand pathophysiological alterations in the body, we performed plasma lipid profiling of 17 patients who suffered from SJS/TEN-associated chronic SOCs...
2016: PloS One
https://www.readbyqxmd.com/read/27875258/sweat-lipid-mediator-profiling-a-non-invasive-approach-for-cutaneous-research
#3
Karan Agrawal, Lauren A Hassoun, Negar Foolad, Theresa L Pedersen, Raja K Sivamani, John William Newman
Recent advances in analytical and sweat collection techniques provide new opportunities to identify non-invasive biomarkers for the study of skin inflammation and repair. This study aims to characterize the lipid mediator profile including oxygenated lipids, endocannabinoids and ceramides/sphingoid bases in sweat and identify differences in these profiles between sweat collected from non-lesional sites on the unflared volar forearm of subjects with and without atopic dermatitis (AD). Adapting routine procedures developed for plasma analysis, over 100 lipid mediators were profiled using liquid chromatography-tandem mass spectrometry and 58 lipid mediators were detected in sweat...
November 8, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27863255/epoxyalcohol-synthase-of-ectocarpus-siliculosus-first-cyp74-related-enzyme-of-oxylipin-biosynthesis-in-brown-algae
#4
Yana Y Toporkova, Valeria S Fatykhova, Yuri V Gogolev, Bulat I Khairutdinov, Lucia S Mukhtarova, Alexander N Grechkin
Enzymes of CYP74 family play the central role in the biosynthesis of physiologically important oxylipins in land plants. Although a broad diversity of oxylipins is known in the algae, no CYP74s or related enzymes have been detected in brown algae yet. Cloning of the first CYP74-related gene CYP5164B1 of brown alga Ectocarpus siliculosus is reported in present work. The recombinant protein was incubated with several fatty acid hydroperoxides. Linoleic acid 9-hydroperoxide (9-HPOD) was the preferred substrate, while linoleate 13-hydroperoxide (13-HPOD) was less efficient...
November 15, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27862864/biological-relevance-of-volatile-organic-compounds-emitted-during-the-pathogenic-interactions-between-apple-plants-and-erwinia-amylovora
#5
Antonio Cellini, Giampaolo Buriani, Lorenzo Rocchi, Elena Rondelli, Stefano Savioli, Maria T Rodriguez Estrada, Simona M Cristescu, Guglielmo Costa, Francesco Spinelli
Volatile organic compounds emitted during the infection of apple (Malus pumila var. domestica) plants by Erwinia amylovora or Pseudomonas syringae pv. syringae were studied by gas chromatography-mass spectrometry and proton transfer reaction-mass spectrometry, and used to treat uninfected plants. Infected plants showed a disease specific emission of volatile organic compounds, including several bio-active compounds, such as hexenal isomers and 2,3-butanediol. Leaf growth promotion and a higher resistance to the pathogen, expressed as a lower bacterial growth and migration in plant tissues, were detected in plants exposed to volatile compounds from E...
November 15, 2016: Molecular Plant Pathology
https://www.readbyqxmd.com/read/27814242/neonatal-cord-blood-oxylipins-and-exposure-to-particulate-matter-in-the-early-life-environment-an-environage-birth-cohort-study
#6
Dries S Martens, Sandra Gouveia, Narjes Madhloum, Bram G Janssen, Michelle Plusquin, Charlotte Vanpoucke, Wouter Lefebvre, Bertil Forsberg, Malin Nording, Tim S Nawrot
BACKGROUND: As part of the lipidome, oxylipins are bioactive lipid compounds originating from oxidation of different fatty acids. Oxylipins could provide a new target in the developmental origins model or the ability of early life exposure to change biology. OBJECTIVES: We studied the association between in utero PM2.5 (particulate matter with aerodynamic diameter <2.5µm) exposure and oxylipin profiles in newborns. METHODS: Thirty-seven oxylipins reflecting the cyclooxygenase (COX), lipoxygenase (5-LOX and 12/15-LOX) and cytochrome P450 (CYP) pathways were assayed in 197 cord blood plasma samples from the ENVIRONAGE birth cohort...
November 4, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27811081/reactive-electrophilic-oxylipins-trigger-a-heat-stress-like-response-through-hsfa1-transcription-factors
#7
Miriam Muench, Chih-Hsuan Hsin, Elena Ferber, Susanne Berger, Martin J Mueller
Abiotic and biotic stresses are often characterized by an induction of reactive electrophile species (RES) such as the jasmonate 12-oxo-phytodienoic acid (OPDA) or the structurally related phytoprostanes. Previously, RES oxylipins have been shown massively to induce heat-shock-response (HSR) genes including HSP101 chaperones. Moreover, jasmonates have been reported to play a role in basal thermotolerance. We show that representative HSR marker genes are strongly induced by RES oxylipins through the four master regulator transcription factors HSFA1a, b, d, and e essential for short-term adaptation to heat stress in Arabidopsis...
November 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27790197/the-nitrogen-availability-interferes-with-mycorrhiza-induced-resistance-against-botrytis-cinerea-in-tomato
#8
Paloma Sanchez-Bel, Pilar Troncho, Jordi Gamir, Maria J Pozo, Gemma Camañes, Miguel Cerezo, Víctor Flors
Mycorrhizal plants are generally quite efficient in coping with environmental challenges. It has been shown that the symbiosis with arbuscular mycorrhizal fungi (AMF) can confer resistance against root and foliar pathogens, although the molecular mechanisms underlying such mycorrhiza-induced resistance (MIR) are poorly understood. Tomato plants colonized with the AMF Rhizophagus irregularis display enhanced resistance against the necrotrophic foliar pathogen Botrytis cinerea. Leaves from arbuscular mycorrhizal (AM) plants develop smaller necrotic lesions, mirrored also by a reduced levels of fungal biomass...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27732914/an-%C3%AF-3-enriched-diet-alone-does-not-attenuate-ccl4-induced-hepatic-fibrosis
#9
Todd R Harris, Sean Kodani, Jun Yang, Denise M Imai, Bruce D Hammock
Exposure to the halogenated hydrocarbon carbon tetrachloride (CCl4) leads to hepatic lipid peroxidation, inflammation and fibrosis. Dietary supplementation of ω-3 fatty acids has been increasingly advocated as being generally anti-inflammatory, though its effect in models of liver fibrosis is mixed. This raises the question of whether diets high in ω-3 fatty acids will result in a greater sensitivity or resistance to liver fibrosis as a result of environmental toxicants like CCl4. In this study, we fed CCl4-treated mice a high ω-3 diet (using a mix of docosahexaenoic acid and eicosapentaenoic acid ethyl esters)...
December 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27729923/volatiles-emitted-from-maize-ears-simultaneously-infected-with-two-fusarium-species-mirror-the-most-competitive-fungal-pathogen
#10
Mohammed Sherif, Eva-Maria Becker, Cornelia Herrfurth, Ivo Feussner, Petr Karlovsky, Richard Splivallo
Along with barley and rice, maize provides staple food for more than half of the world population. Maize ears are regularly infected with fungal pathogens of the Fusarium genus, which, besides reducing yield, also taint grains with toxic metabolites. In an earlier work, we have shown that maize ears infection with single Fusarium strains was detectable through volatile sensing. In nature, infection most commonly occurs with more than a single fungal strain; hence we tested how the interactions of two strains would modulate volatile emission from infected ears...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27704278/comparison-of-headspace-oxylipin-volatilomes-of-some-eastern-himalayan-mosses-extracted-by-sample-enrichment-probe-and-analysed-by-gas-chromatography-mass-spectrometry
#11
Souvik Mitra, Barend V Burger, Mousumi Poddar-Sarkar
Mosses have an inherent adaptability against different biotic and abiotic stresses. Oxylipins, the volatile metabolites derived from polyunsaturated fatty acids (PUFAs), play a key role in the chemical defence strategy of mosses. In the present study, a comparative survey of these compounds, including an investigation into their precursor fatty acids (FAs), was carried out for the first time on the mosses Brachymenium capitulatum (Mitt.) Paris, Hydrogonium consanguineum (Thwaites & Mitt.) Hilp., Barbula hastata Mitt...
October 5, 2016: Protoplasma
https://www.readbyqxmd.com/read/27633106/omega-3-polyunsaturated-fatty-acids-and-oxylipins-in-neuroinflammation-and-management-of-alzheimer-disease
#12
REVIEW
Jessay Gopuran Devassy, Shan Leng, Melissa Gabbs, Md Monirujjaman, Harold M Aukema
Alzheimer disease (AD) is becoming one of the most prevalent neurodegenerative conditions worldwide. Although the disease progression is becoming better understood, current medical interventions can only ameliorate some of the symptoms but cannot slow disease progression. Neuroinflammation plays an important role in the advancement of this disorder, and n-3 (ω-3) polyunsaturated fatty acids (PUFAs) are involved in both the reduction in and resolution of inflammation. These effects may be mediated by the anti-inflammatory and proresolving effects of bioactive lipid mediators (oxylipins) derived from n-3 PUFAs [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] in fish oil...
September 2016: Advances in Nutrition
https://www.readbyqxmd.com/read/27631111/exploring-the-inflammatory-metabolomic-profile-to-predict-response-to-tnf-%C3%AE-inhibitors-in-rheumatoid-arthritis
#13
Bart V J Cuppen, Junzeng Fu, Herman A van Wietmarschen, Amy C Harms, Slavik Koval, Anne C A Marijnissen, Judith J W Peeters, Johannes W J Bijlsma, Janneke Tekstra, Jacob M van Laar, Thomas Hankemeier, Floris P J G Lafeber, Jan van der Greef
In clinical practice, approximately one-third of patients with rheumatoid arthritis (RA) respond insufficiently to TNF-α inhibitors (TNFis). The aim of the study was to explore the use of a metabolomics to identify predictors for the outcome of TNFi therapy, and study the metabolomic fingerprint in active RA irrespective of patients' response. In the metabolomic profiling, lipids, oxylipins, and amines were measured in serum samples of RA patients from the observational BiOCURA cohort, before start of biological treatment...
2016: PloS One
https://www.readbyqxmd.com/read/27611078/the-recently-identified-isoleucine-conjugate-of-cis-12-oxo-phytodienoic-acid-is-partially-active-in-cis-12-oxo-phytodienoic-acid-specific-gene-expression-of-arabidopsis-thaliana
#14
Monika D Arnold, Cornelia Gruber, Kristýna Floková, Otto Miersch, Miroslav Strnad, Ondřej Novák, Claus Wasternack, Bettina Hause
Oxylipins of the jasmonate family are active as signals in plant responses to biotic and abiotic stresses as well as in development. Jasmonic acid (JA), its precursor cis-12-oxo-phytodienoic acid (OPDA) and the isoleucine conjugate of JA (JA-Ile) are the most prominent members. OPDA and JA-Ile have individual signalling properties in several processes and differ in their pattern of gene expression. JA-Ile, but not OPDA, is perceived by the SCFCOI1-JAZ co-receptor complex. There are, however, numerous processes and genes specifically induced by OPDA...
2016: PloS One
https://www.readbyqxmd.com/read/27583776/effect-of-soluble-epoxide-hydrolase-on-the-modulation-of-coronary-reactive-hyperemia-role-of-oxylipins-and-ppar%C3%AE
#15
Ahmad Hanif, Matthew L Edin, Darryl C Zeldin, Christophe Morisseau, Mohammed A Nayeem
Coronary reactive hyperemia (CRH) is a physiological response to ischemic insult that prevents the potential harm associated with an interruption of blood supply. The relationship between the pharmacologic inhibition of soluble epoxide hydrolase (sEH) and CRH response to a brief ischemia is not known. sEH is involved in the main catabolic pathway of epoxyeicosatrienoic acids (EETs), which are converted into dihydroxyeicosatrienoic acids (DHETs). EETs protect against ischemia/reperfusion injury and have numerous beneficial physiological effects...
2016: PloS One
https://www.readbyqxmd.com/read/27541690/dietary-marine-%C3%AF-3-fatty-acids-and-incident-sight-threatening-retinopathy-in-middle-aged-and-older-individuals-with-type-2-diabetes-prospective-investigation-from-the-predimed-trial
#16
Aleix Sala-Vila, Andrés Díaz-López, Cinta Valls-Pedret, Montserrat Cofán, Alfredo García-Layana, Rosa-María Lamuela-Raventós, Olga Castañer, Vicente Zanon-Moreno, Miguel A Martinez-Gonzalez, Estefanía Toledo, Josep Basora, Jordi Salas-Salvadó, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, Ramón Estruch, José Lapetra, Montserrat Fitó, Fernando Arós, Luis Serra-Majem, Xavier Pintó, Emilio Ros
Importance: Diabetic retinopathy (DR) is a devastating complication of individuals with type 2 diabetes mellitus. The retina is rich in long-chain ω-3 polyunsaturated fatty acids (LCω3PUFAs), which are substrate for oxylipins with anti-inflammatory and antiangiogenic properties. Experimental models support dietary LCω3PUFA protection against DR, but clinical data are lacking. Objective: To determine whether LCω3PUFA intake relates to a decreased incidence of sight-threatening DR in individuals with type 2 diabetes older than 55 years...
October 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27540171/coordinative-alignment-of-molecules-in-chiral-metal-organic-frameworks
#17
Seungkyu Lee, Eugene A Kapustin, Omar M Yaghi
A chiral metal-organic framework, MOF-520, was used to coordinatively bind and align molecules of varying size, complexity, and functionality. The reduced motional degrees of freedom obtained with this coordinative alignment method allowed the structures of molecules to be determined by single-crystal x-ray diffraction techniques. The chirality of the MOF backbone also served as a reference in the structure solution for an unambiguous assignment of the absolute configuration of bound molecules. Sixteen molecules representing four common functional groups (primary alcohol, phenol, vicinal diol, and carboxylic acid), ranging in complexity from methanol to plant hormones (gibberellins, containing eight stereocenters), were crystallized and had their precise structure determined...
August 19, 2016: Science
https://www.readbyqxmd.com/read/27528063/dietary-flaxseed-reduces-central-aortic-blood-pressure-without-cardiac-involvement-but-through-changes-in-plasma-oxylipins
#18
Stephanie P B Caligiuri, Delfin Rodriguez-Leyva, Harold M Aukema, Amir Ravandi, Wendy Weighell, Randolph Guzman, Grant N Pierce
UNLABELLED: In the year-long FlaxPAD clinical trial (Flaxseed for Peripheral Artery Disease), dietary flaxseed generated a powerful reduction in brachial systolic and diastolic blood pressure in patients with peripheral artery disease. Oxylipins were implicated as potential mechanistic mediators. However, the ability of flaxseed to impact central aortic hypertension, arterial stiffness, or cardiac performance was not investigated. Additionally, the relationship between central blood pressure (cBP) and oxylipins was not elucidated...
October 2016: Hypertension
https://www.readbyqxmd.com/read/27496085/mechanisms-of-dha-transport-to-the-brain-and-potential-therapy-to-neurodegenerative-diseases
#19
Amanda Lo Van, Nobuyuki Sakayori, Mayssa Hachem, Mounir Belkouch, Madeleine Picq, Michel Lagarde, Noriko Osumi, Nathalie Bernoud-Hubac
Docosahexaenoic acid (DHA; 22:6 ω-3) is highly enriched in the brain and is required for proper brain development and function. Its deficiency has been shown to be linked with the emergence of neurological diseases. Dietary ω-3 fatty acid supplements including DHA have been suggested to improve neuronal development and enhance cognitive functions. However, mechanisms of DHA incorporation in the brain remain to be fully understood. Findings suggested that DHA is better incorporated when esterified within lysophospholipid rather than under its non-esterified form...
August 2, 2016: Biochimie
https://www.readbyqxmd.com/read/27488890/deletion-of-soluble-epoxide-hydrolase-enhances-coronary-reactive-hyperemia-in-isolated-mouse-heart-role-of-oxylipins-and-ppar%C3%AE
#20
Ahmad Hanif, Matthew L Edin, Darryl C Zeldin, Christophe Morisseau, Mohammed A Nayeem
The relationship between soluble epoxide hydrolase (sEH) and coronary reactive hyperemia (CRH) response to a brief ischemic insult is not known. Epoxyeicosatrienoic acids (EETs) exert cardioprotective effects in ischemia/reperfusion injury. sEH converts EETs into dihydroxyeicosatrienoic-acids (DHETs). Therefore, we hypothesized that knocking out sEH enhances CRH through modulation of oxylipin profiles, including an increase in EET/DHET ratio. Compared with sEH(+/+), sEH(-/-) mice showed enhanced CRH, including greater repayment volume (RV; 28% higher, P < 0...
October 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
keyword
keyword
119278
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"