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https://www.readbyqxmd.com/read/28715485/characterization-of-the-maize-lipoxygenase-gene-family-in-relation-to-aflatoxin-accumulation-resistance
#1
Oluwaseun F Ogunola, Leigh K Hawkins, Erik Mylroie, Michael V Kolomiets, Eli Borrego, Juliet D Tang, W Paul Williams, Marilyn L Warburton
Maize (Zea mays L.) is a globally important staple food crop prone to contamination by aflatoxin, a carcinogenic secondary metabolite produced by the fungus Aspergillus flavus. An efficient approach to reduce accumulation of aflatoxin is the development of germplasm resistant to colonization and toxin production by A. flavus. Lipoxygenases (LOXs) are a group of non-heme iron containing dioxygenase enzymes that catalyze oxygenation of polyunsaturated fatty acids (PUFAs). LOX derived oxylipins play critical roles in plant defense against pathogens including A...
2017: PloS One
https://www.readbyqxmd.com/read/28714336/specific-plasma-oxylipins-increase-the-odds-of-cardiovascular-and-cerebrovascular-events-in-patients-with-peripheral-artery-disease
#2
Stephanie Caligiuri, Harold M Aukema, Amir Ravandi, Renee Lavallee, Randolph Guzman, Grant N Pierce
Oxylipins and fatty acids may be novel therapeutic targets for cardiovascular disease. The objective was to determine if plasma oxylipins or fatty acids can influence the odds of cardiovascular/cerebrovascular events. In 98 patients (25 female, 73 male) with peripheral artery disease, the prevalence of transient ischemic attacks, cerebrovascular accidents, stable angina and acute coronary syndrome was n= 16, 10, 16, and 24, respectively. Risk factors such as being male, diagnosed hypertension, diabetes mellitus, and hyperlipidemia were not associated with events...
July 15, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28709649/analysis-of-oxylipins-in-human-plasma-comparison-of-ultrahigh-performance-liquid-chromatography-and-ultrahigh-performance-supercritical-fluid-chromatography-coupled-to-mass-spectrometry
#3
Róbert Berkecz, Miroslav Lísa, Michal Holčapek
The potential of ultrahigh-performance liquid chromatography-mass spectrometry (UHPLC/MS) and ultrahigh-performance supercritical fluid chromatography (UHPSFC) coupled to negative-ion electrospray ionization mass spectrometry (ESI-MS) for the analysis of 46 oxylipins and 2 fatty acid standards is compared in terms of their chromatographic resolution with the emphasis on distinguishing isobaric interferences and the method sensitivity. UHPLC provides the baseline separation of 24 isobaric oxylipins within 13min, while UHPSFC enables the separation of only 20 isobaric oxylipins within 8min...
June 29, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28682409/effects-of-omega-3-fatty-acid-supplementation-on-the-pattern-of-oxylipins-a-short-review-about-the-modulation-of-hydroxy-dihydroxy-and-epoxy-fatty-acids
#4
REVIEW
Annika I Ostermann, Nils Helge Schebb
A growing body of evidence suggests that the intake of the long chain omega-3 polyunsaturated fatty acids (n3-PUFA) eicosapentaenoic acid (C20:5 n3, EPA) and docosahexaenoic acid (C22:6 n3, DHA) is linked to beneficial health effects, particularly in the prevention of cardiovascular and inflammatory diseases. Although the molecular mode of action of n3-PUFA is still not fully understood, it is not controversial that a significant portion of the (patho)-physiological effects of PUFA are mediated by their oxidative metabolites, i...
July 6, 2017: Food & Function
https://www.readbyqxmd.com/read/28667077/dietary-linoleic-acid-and-sex-effects-on-oxylipin-profiles-in-rat-kidney-liver-and-serum-differ-from-their-effects-on-polyunsaturated-fatty-acids
#5
Shan Leng, Tanja Winter, Harold M Aukema
A vast literature on fatty acids in mammals exists, but comparable compositional data on oxylipins is lacking. Weanling Sprague-Dawley rats were therefore provided control diets or diets with higher linoleic acid (LA), or with higher LA and α-linolenic acid (LA+ALA) for six weeks. Kidneys, livers and serum were analyzed for oxylipins and fatty acids. The proportion of tissue oxylipins derived from LA was greater than the relative proportion of LA itself, while arachidonic acid (AA) oxylipins were overrepresented in serum...
June 30, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28651702/effect-of-dha-supplementation-on-oxylipin-levels-in-plasma-and-immune-cell-stimulated-blood
#6
Jan Philipp Schuchardt, Annika I Ostermann, Lisa Stork, Sabrina Fritzsch, Heike Kohrs, Theresa Greupner, Andreas Hahn, Nils Helge Schebb
INTRODUCTION: EPA and DHA cause different physiological effects, which are in many cases mediated via their oxidative metabolites (oxylipins). However, metabolism studies investigating the effect of either EPA or DHA on comprehensive oxylipin patterns are lacking. MATERIAL AND METHODS: The short and long term (1, 3, 6, and 12 week) effect of 1076mg/d DHA (free of EPA) on free (unesterified) oxylipin concentrations in plasma and lipopolysacharid (LPS) stimulated blood of 12 healthy men (mean age 25...
June 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28651699/levels-of-oxylipins-endocannabinoids-and-related-lipids-in-plasma-before-and-after-low-level-exposure-to-acrolein-in-healthy-individuals-and-individuals-with-chemical-intolerance
#7
Anna-Sara Claeson, Sandra Gouveia-Figueira, Jenny Häggström, Christopher J Fowler, Malin L Nording
Oxylipins and endocannabinoids play important biological roles, including effects upon inflammation. It is not known whether the circulating levels of these lipids are affected by inhalation of the environmental pollutant acrolein. In the present study, we have investigated the consequences of low-level exposure to acrolein on oxylipin, endocannabinoid and related lipid levels in the plasma of healthy individuals and individuals with chemical intolerance (CI), an affliction with a suggested inflammatory origin...
June 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28651692/long-chain-fatty-acids-and-related-pro-inflammatory-specialized-pro-resolving-lipid-mediators-and-their-intermediates-in-preterm-human-milk-during-the-first-month-of-lactation
#8
D T Robinson, H L Palac, V Baillif, E Van Goethem, M Dubourdeau, L Van Horn, C R Martin
This study aimed to measure longitudinal quantities of the long chain fatty acids, their biologically active terminal metabolites and related intermediates (also called oxylipins) in preterm human milk expressed during the first month of lactation. In a prospective cohort, breast milk was collected throughout the first month of lactation in 30 women who delivered preterm infants. Eighteen bioactive lipids and their intermediates were quantified via solid phase extraction and LC-MS/MS. Analysis by GC-FID quantified the fatty acid precursors...
June 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28647505/identification-of-mapks-as-signal-transduction-components-required-for-the-cell-death-response-during-compatible-infection-by-the-synergistic-pair-potato-virus-x-potato-virus-y
#9
Emmanuel Aguilar, Francisco J Del Toro, Tomás Canto, Francisco Tenllado
Systemic necrosis is one of the most severe symptoms caused in compatible plant-virus interactions and shares common features with the hypersensitive response (HR). Mitogen-activated protein kinase (MAPK) cascades are associated with responses to compatible and incompatible host-virus interactions. Here, we show that virus-induced gene silencing of the Nicotiana benthamiana MAPK genes salicylic acid-induced protein kinase (SIPK) and wound-induced protein kinase (WIPK), and the MAPK kinase (MAPKK) genes MEK1 and MKK1, partially compromised the HR-like response induced by the synergistic interaction of Potato virus X with Potato virus Y (PVX-PVY)...
June 22, 2017: Virology
https://www.readbyqxmd.com/read/28644561/the-redox-sensitive-module-of-cyclophilin-20-3-2-cysteine-peroxiredoxin-and-cysteine-synthase-integrates-sulfur-metabolism-and-oxylipin-signaling-in-the-high-light-acclimation-response
#10
Sara M Müller, Shanshan Wang, Wilena Telman, Michael Liebthal, Helena Schnitzer, Andrea Viehhauser, Carsten Sticht, Carolina Delatorre, Markus Wirtz, Rüdiger Hell, Karl-Josef Dietz
The integration of redox- and reactive oxygen species-dependent signaling and metabolic activities are fundamental to plant acclimation to biotic and abiotic stresses. Previous data suggest the existence of a dynamically interacting module in the chloroplast stroma consisting of cyclophilin 20-3 (Cyp20-3), O-acetylserine(thiol)lyase B (OASTL-B), 2-cysteine peroxiredoxins A/B (2-CysPrx) and serine acetyltransferase 2;1 (SERAT2;1). The functionality of this COPS module is influenced by redox stimuli and oxophytodienoic acid (OPDA) which is the precursor for jasmonic acid...
June 23, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28583889/a-diet-rich-in-omega-3-fatty-acids-enhances-expression-of-soluble-epoxide-hydrolase-in-murine-brain
#11
Annika Irmgard Ostermann, Martina Reutzel, Nicole Hartung, Nicole Franke, Laura Kutzner, Kirsten Schoenfeld, Karsten-Henrich Weylandt, Gunter Peter Eckert, Nils Helge Schebb
Several studies suggest that intake of omega-3 polyunsaturated fatty acids (n3-PUFA) beneficially influences cognitive function. However, effects on the adult brain are not clear. Little is known about the impact of dietary intervention on the fatty acid profile in adult brain, the modulation in the expression of enzymes involved in fatty acid biosynthesis and metabolism as well as changes in resulting oxylipins. These questions were addressed in the present study in two independent n3-PUFA feeding experiments in mice...
June 3, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28582415/defense-related-decadienal-elicits-membrane-lipid-remodeling-in-the-diatom-phaeodactylum-tricornutum
#12
Tanya Sabharwal, Kanagasabapathi Sathasivan, Mona C Mehdy
Diatoms rapidly release extracellular oxylipins (oxygenated lipids) including polyunsaturated aldehydes in response to herbivory and other stresses. Oxylipins have several defense-related activities including inhibition of reproduction in herbivores and signaling to distant diatoms. Physiological changes in diatoms exposed to varying levels of oxylipins are only beginning to be understood. In this study, Phaeodactylum tricornutum cultures were treated with sublethal concentrations of the polyunsaturated aldehyde trans,trans-2,4-decadienal (DD) to assess effects on lipid composition and membrane permeability...
2017: PloS One
https://www.readbyqxmd.com/read/28578135/oxylipin-mediated-stress-response-of-a-miraculin-like-protease-inhibitor-in-hexanoic-acid-primed-eggplant-plants-infested-by-colorado-potato-beetle
#13
M José López-Galiano, Víctor Manuel Ruiz-Arroyo, Emma Fernández-Crespo, Carolina Rausell, M Dolores Real, Pilar García-Agustín, Carmen González-Bosch, Inmaculada García-Robles
Insect-plant interactions are governed by a complex equilibrium between the mechanisms through which plant recognize insect attack and orchestrate downstream signaling events that trigger plant defense responses, and the mechanisms by which insects overcome plant defenses. Due to this tight and dynamic interplay, insight into the nature of the plant defense response can be gained by analyzing changes in the insect herbivores digestive system upon plant feeding. In this work we have identified a Solanum melongena miraculin-like protease inhibitor in the midgut juice of Colorado potato larvae feeding on eggplant plants treated with the natural inducer of plant defenses hexanoic acid...
May 4, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28561789/careful-with-that-axe-gene-genome-perturbation-after-a-peg-mediated-protoplast-transformation-in-fusarium-verticillioides
#14
Valeria Scala, Alessandro Grottoli, Riccardo Aiese Cigliano, Irantzu Anzar, Marzia Beccaccioli, Corrado Fanelli, Chiara Dall'Asta, Paola Battilani, Massimo Reverberi, Walter Sanseverino
Fusarium verticillioides causes ear rot disease in maize and its contamination with fumonisins, mycotoxins harmful for humans and livestock. Lipids, and their oxidized forms, may drive the fate of this disease. In a previous study, we have explored the role of oxylipins in this interaction by deleting by standard transformation procedures a linoleate diol synthase-coding gene, lds1, in F. verticillioides. A profound phenotypic diversity in the mutants generated has prompted us to investigate more deeply the whole genome of two lds1-deleted strains...
May 31, 2017: Toxins
https://www.readbyqxmd.com/read/28560878/serial-metabolome-changes-in-a-prospective-cohort-of-subjects-with-influenza-viral-infection-and-comparison-with-dengue-fever
#15
Liang Cui, Jinling Fang, Eng Eong Ooi, Yie Hou Lee
Influenza virus infection (IVI) and dengue virus infection (DVI) are major public health threats. Between IVI and DVI, clinical symptoms can be overlapping yet infection-specific, but host metabolome changes are not well-described. Untargeted metabolomics and targeted oxylipinomic analyses were performed on sera serially collected at three phases of infection from a prospective cohort study of adult subjects with either H3N2 influenza infection or dengue fever. Untargeted metabolomics identified 26 differential metabolites, and major perturbed pathways included purine metabolism, fatty acid biosynthesis and β-oxidation, tryptophan metabolism, phospholipid catabolism, and steroid hormone pathway...
June 12, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28536571/lipoxygenase-activity-accelerates-programmed-spore-germination-in-aspergillus-fumigatus
#16
Gregory J Fischer, William Bacon, Jun Yang, Jonathan M Palmer, Taylor Dagenais, Bruce D Hammock, Nancy P Keller
The opportunistic human pathogen Aspergillus fumigatus initiates invasive growth through a programmed germination process that progresses from dormant spore to swollen spore (SS) to germling (GL) and ultimately invasive hyphal growth. We find a lipoxygenase with considerable homology to human Alox5 and Alox15, LoxB, that impacts the transitions of programmed spore germination. Overexpression of loxB (OE::loxB) increases germination with rapid advance to the GL stage. However, deletion of loxB (ΔloxB) or its signal peptide only delays progression to the SS stage in the presence of arachidonic acid (AA); no delay is observed in minimal media...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28528513/the-expansive-role-of-oxylipins-on-platelet-biology
#17
REVIEW
Jennifer Yeung, Megan Hawley, Michael Holinstat
In mammals, three major oxygenases, cyclooxygenases (COXs), lipoxygenases (LOXs), and cytochrome P450 (CYP450), generate an assortment of unique lipid mediators (oxylipins) from polyunsaturated fatty acids (PUFAs) which exhibit pro- or anti-thrombotic activity. Over the years, novel oxylipins generated from the interplay of theoxygenase activity in various cells, such as the specialized pro-resolving mediators (SPMs), have been identified and investigated in inflammatory disease models. Although platelets have been implicated in inflammation, the role and mechanism of these SPMs produced from immune cells on platelet function are still unclear...
June 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28524103/potential-impact-of-nutrition-on-immune-system-recovery-from-heavy-exertion-a-metabolomics-perspective
#18
REVIEW
David C Nieman, Susan Hazels Mitmesser
This review describes effective and ineffective immunonutrition support strategies for the athlete, with a focus on the benefits of carbohydrates and polyphenols as determined from metabolomics-based procedures. Athletes experience regular cycles of physiological stress accompanied by transient inflammation, oxidative stress, and immune perturbations, and there are increasing data indicating that these are sensitive to nutritional influences. The most effective nutritional countermeasures, especially when considered from a metabolomics perspective, include acute and chronic increases in dietary carbohydrate and polyphenols...
May 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28515018/plasma-levels-of-the-endocannabinoid-anandamide-related-n-acylethanolamines-and-linoleic-acid-derived-oxylipins-in-patients-with-migraine
#19
Sandra Gouveia-Figueira, Kristina Goldin, Sanaz A Hashemian, Agneta Lindberg, Monica Persson, Malin L Nording, Katarina Laurell, Christopher J Fowler
There is evidence that patients with migraine have deficient levels of the endogenous cannabinoid receptor ligand anandamide (AEA). It is not known, however, if this is a localised or generalised phenomenon. In the present study, levels of AEA, related N-acylethanolamines (NAEs) and linoleic acid-derived oxylipins have been measured in the blood of 26 healthy women and 38 women with migraine (26 with aura, 12 without aura) who were matched for age and body-mass index. Blood samples were taken on two occasions: the first sample near the start of the menstrual cycle (when present) and the second approximately fourteen days later...
May 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28506062/lc-ms-untargeted-metabolomics-to-explain-the-signal-metabolites-inducing-browning-in-fresh-cut-lettuce
#20
Carlos J García, Rocío García-Villalba, María I Gil, Francisco A Tomas-Barberan
Enzymatic browning is one of the main causes of quality loss in lettuce as a prepared and ready-to-eat cut salad. An untargeted metabolomics approach using UPLC-ESI-QTOF-MS was performed to explain the wound response of lettuce after cutting and to identify the metabolites responsible of browning. Two cultivars of Romaine lettuce with different browning susceptibilities were studied at short time intervals after cutting. From the total 5975 entities obtained from the raw data after alignment, filtration reduced the number of features to 2959, and the statistical analysis found that only 1132 entities were significantly different...
June 7, 2017: Journal of Agricultural and Food Chemistry
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