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https://www.readbyqxmd.com/read/28981289/using-curvature-power-to-map-the-domain-of-inverse-micellar-cubic-phases-the-case-of-aliphatic-aldehydes-in-1-2-dioleoyl-sn-glycero-3-phosphoethanolamine
#1
Jamie Burrell, Marcus K Dymond, Richard James Gillams, Duncan J Parker, G John Langley, Ana Maria Labrador, Tommy Nylander, George S Attard
Oxylipins, or fatty aldehydes, are a class of molecules produced from membrane lipids as a result of oxidative stress or enzyme-mediated peroxidation. Here we report the effects of two biologically important fatty aldehydes, trans, trans-2,4-decanedienal (DD) and cis-11-hexadecenal (HD), on the phase behaviour of the lipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) in water. We compare the phase behaviour of DD/DOPE and HD/DOPE mixtures to the phase behaviour of oleic acid/ DOPE mixtures and show that DD, HD and oleic acid have similar effects on the phase diagrams of DOPE...
October 5, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28970503/omega-6-and-omega-3-oxylipins-are-implicated-in-soybean-oil-induced-obesity-in-mice
#2
Poonamjot Deol, Johannes Fahrmann, Jun Yang, Jane R Evans, Antonia Rizo, Dmitry Grapov, Michelle Salemi, Kwanjeera Wanichthanarak, Oliver Fiehn, Brett Phinney, Bruce D Hammock, Frances M Sladek
Soybean oil consumption is increasing worldwide and parallels a rise in obesity. Rich in unsaturated fats, especially linoleic acid, soybean oil is assumed to be healthy, and yet it induces obesity, diabetes, insulin resistance, and fatty liver in mice. Here, we show that the genetically modified soybean oil Plenish, which came on the U.S. market in 2014 and is low in linoleic acid, induces less obesity than conventional soybean oil in C57BL/6 male mice. Proteomic analysis of the liver reveals global differences in hepatic proteins when comparing diets rich in the two soybean oils, coconut oil, and a low-fat diet...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28956853/lipidomics-unravels-the-role-of-leaf-lipids-in-thyme-plant-response-to-drought-stress
#3
Parviz Moradi, Atiyeh Mahdavi, Maryam Khoshkam, Marcello Iriti
Thymus is one of the best known genera within the Labiatae (Lamiaceae) family, with more than 200 species and many medicinal and culinary uses. The effects of prolonged drought on lipid profile were investigated in tolerant and sensitive thyme plants (Thymus serpyllum L. and Thymus vulgaris L., respectively). Non-targeted non-polar metabolite profiling was carried out using Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry with one-month-old plants exposed to drought stress, and their morpho-physiological parameters were also evaluated...
September 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28956582/effect-of-the-dietary-intake-of-melatonin-and-hydroxytyrosol-rich-wines-by-healthy-female-volunteers-on-the-systemic-lipidomic-related-oxylipins
#4
Javier Marhuenda, Sonia Medina, Pedro Martínez-Hernández, Simon Arina, Pilar Zafrilla, Juana Mulero, Camille Oger, Jean-Marie Galano, Thierry Durand, Antonio Solana, Federico Ferreres, Juan José López-García, Angel Gil-Izquierdo
Oxylipins are lipid mediators involved in the physiopathology of all organs. Moreover, isoprostanes have been established as general and reliable in vivo oxidative stress biomarkers. Red wine has proved to exert several benefits through the maintenance of the oxidative balance of the organism. Antiradical scavenging capacity has been mainly attributed to polyphenols. However, melatonin and hydroxytyrosol should be taken into account as potent antiradical agents. The present research aimed to clarify the situation of enzymatic and oxidative injury and eicosanoid urinary excretion related to the intake of three kinds of red wines and their primary musts...
September 28, 2017: Food & Function
https://www.readbyqxmd.com/read/28890385/reduced-coronary-reactive-hyperemia-in-mice-was-reversed-by-the-soluble-epoxide-hydrolase-inhibitor-t-aucb-role-of-adenosine-a2a-receptor-and-plasma-oxylipins
#5
Ahmad Hanif, Matthew L Edin, Darryl C Zeldin, Christophe Morisseau, John R Falck, Catherine Ledent, Stephen L Tilley, Mohammed A Nayeem
Coronary reactive hyperemia (CRH) protects the heart against ischemia. Adenosine A2AAR-deficient (A2AAR(-/-)) mice have increased expression of soluble epoxide hydrolase (sEH); the enzyme responsible for breaking down the cardioprotective epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs). sEH-inhibition enhances CRH, increases EETs, and modulates oxylipin profiles. We investigated the changes of oxylipins and their impact on CRH in A2AAR(-/-) and wild type (WT) mice. We hypothesized that the attenuated CRH in A2AAR(-/-) mice is mediated by changes in oxylipin profiles, and that it can be reversed by either sEH- or ω-hydroxylases-inhibition...
July 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28889752/covalent-immobilization-of-oxylipin-biosynthetic-enzymes-on-nanoporous-rice-husk-silica-for-production-of-cis-12-oxophytodienoic-acid
#6
Thu Bao Le, Chong Soo Han, Kyoungwon Cho, Oksoo Han
Soybean lipoxygenase, recombinant rice allene oxide synthase-1 and rice allene oxide cyclase were covalently immobilized on nanoporous rice husk silica using two types of linkers: glutardialdehyde and polyethylene glycol. The immobilization efficiency achieved using glutardialdehyde-linked rice husk silica was higher than that achieved using polyethylene glycol-linked rice husk silica (50-92% and 25-50%, respectively). Immobilization on both types of matrices significantly decreased the specific activities of the immobilized enzymes...
September 11, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28886714/the-oxylipin-and-endocannabidome-responses-in-acute-phase-plasmodium-falciparum-malaria-in-children
#7
Izabella Surowiec, Sandra Gouveia-Figueira, Judy Orikiiriza, Elisabeth Lindquist, Mari Bonde, Jimmy Magambo, Charles Muhinda, Sven Bergström, Johan Normark, Johan Trygg
BACKGROUND: Oxylipins and endocannabinoids are low molecular weight bioactive lipids that are crucial for initiation and resolution of inflammation during microbial infections. Metabolic complications in malaria are recognized contributors to severe and fatal malaria, but the impact of malaria infection on the production of small lipid derived signalling molecules is unknown. Knowledge of immunoregulatory patterns of these molecules in malaria is of great value for better understanding of the disease and improvement of treatment regimes, since the action of these classes of molecules is directly connected to the inflammatory response of the organism...
September 8, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28886129/modulation-of-the-endogenous-omega-3-fatty-acid-and-oxylipin-profile-in-vivo-a-comparison-of-the-fat-1-transgenic-mouse-with-c57bl-6-wildtype-mice-on-an-omega-3-fatty-acid-enriched-diet
#8
Annika I Ostermann, Patrick Waindok, Moritz J Schmidt, Cheng-Ying Chiu, Christopher Smyl, Nadine Rohwer, Karsten-H Weylandt, Nils Helge Schebb
Dietary intervention and genetic fat-1 mice are two models for the investigation of effects associated with omega-3 polyunsaturated fatty acids (n3-PUFA). In order to assess their power to modulate the fatty acid and oxylipin pattern, we thoroughly compared fat-1 and wild-type C57BL/6 mice on a sunflower oil diet with wild-type mice on the same diet enriched with 1% EPA and 1% DHA for 0, 7, 14, 30 and 45 days. Feeding led after 14-30 days to a high steady state of n3-PUFA in all tissues at the expense of n6-PUFAs...
2017: PloS One
https://www.readbyqxmd.com/read/28863368/postprandial-effect-to-decrease-soluble-epoxide-hydrolase-activity-roles-of-insulin-and-gut-microbiota
#9
Jun Yang, Young Taek Oh, Debin Wan, Richard M Watanabe, Bruce D Hammock, Jang H Youn
Epoxides of free fatty acids (FFAs), especially epoxyeicosatrienoic acids (EETs), are lipid mediators with beneficial effects in metabolic and cardiovascular (CV) health. FFA epoxides are quickly metabolized to biologically less active diols by soluble epoxide hydrolase (sEH). Inhibition of sEH, which increases EET levels, improves glucose homeostasis and CV health and is proposed as an effective strategy for the treatment of diabetes and CV diseases. Here, we show evidence that sEH activity is profoundly reduced in postprandial states in rats; plasma levels of 17 sEH products (i...
July 21, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28839213/metabolomic-compounds-identified-in-piriformospora-indica-colonized-chinese-cabbage-roots-delineate-symbiotic-functions-of-the-interaction
#10
Mo Da-Sang Hua, Rajendran Senthil Kumar, Lie-Fen Shyur, Yuan-Bin Cheng, Zhihong Tian, Ralf Oelmüller, Kai-Wun Yeh
Root colonization by endophytic fungus Piriformospora indica facilitating growth/development and stress tolerance has been demonstrated in various host plants. However, global metabolomic studies are rare. By using high-throughput gas-chromatography-based mass spectrometry, 549 metabolites of 1,126 total compounds observed were identified in colonized and uncolonized Chinese cabbage roots, and hyphae of P. indica. The analyses demonstrate that the host metabolomic compounds and metabolite pathways are globally reprogrammed after symbiosis with P...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28838555/distinct-effects-of-dietary-flax-compared-to-fish-oil-soy-protein-compared-to-casein-and-sex-on-the-renal-oxylipin-profile-in-models-of-polycystic-kidney-disease
#11
Jessay G Devassy, Tamio Yamaguchi, Md Monirujjaman, Melissa Gabbs, Amir Ravandi, Jing Zhou, Harold M Aukema
Oxylipins are bioactive lipids derived from polyunsaturated fatty acids (PUFA) that are important regulators of kidney function and health. Targeted lipidomic analyses of renal oxylipins from four studies of rodent models of renal disease were performed to investigate the differential effects of dietary flax compared to fish oil, soy protein compared to casein, and sex. Across all studies, dietary fish oil was more effective than flax oil in reducing n-6 PUFA derived oxylipins and elevating eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) derived oxylipins, whereas dietary flax oil resulted in higher α-linolenic acid (ALA) oxylipins...
August 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28826940/distinct-oxylipin-alterations-in-diverse-models-of-cystic-kidney-diseases
#12
Md Monirujjaman, Jessay G Devassy, Tamio Yamaguchi, Nikhil Sidhu, Masanori Kugita, Melissa Gabbs, Shizuko Nagao, Jing Zhou, Amir Ravandi, Harold M Aukema
Cystic kidney diseases are characterized by multiple renal cysts and are the leading cause of inherited renal disease. Oxylipins are bioactive lipids derived from fatty acids formed via cyclooxygenase, lipoxygenase and cytochrome P450 activity, and are important regulators of renal health and disease. Oxylipins are altered in nephronophthisis, a type of cystic kidney disease. To further investigate and to determine whether other cystic renal diseases share these abnormalities, a targeted lipidomic analysis of renal oxylipins was performed in orthologous models of autosomal dominant polycystic kidney disease 1 (Mx1Cre(+)Pkd1(flox/flox) mouse) and 2 (Pkd2(ws25/-) mouse), autosomal recessive polycystic kidney disease (PCK rat) and nephronophthisis (jck/jck mouse)...
December 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28808104/interaction-between-photosynthetic-electron-transport-and-chloroplast-sinks-triggers-protection-and-signalling-important-for-plant-productivity
#13
Peter J Gollan, Yugo Lima-Melo, Arjun Tiwari, Mikko Tikkanen, Eva-Mari Aro
The photosynthetic light reactions provide energy that is consumed and stored in electron sinks, the products of photosynthesis. A balance between light reactions and electron consumption in the chloroplast is vital for plants, and is protected by several photosynthetic regulation mechanisms. Photosystem I (PSI) is particularly susceptible to photoinhibition when these factors become unbalanced, which can occur in low temperatures or in high light. In this study we used the pgr5 Arabidopsis mutant that lacks ΔpH-dependent regulation of photosynthetic electron transport as a model to study the consequences of PSI photoinhibition under high light...
September 26, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28801523/dietary-modulation-of-oxylipins-in-cardiovascular-disease-and-aging
#14
Stephanie P B Caligiuri, Mihir Parikh, Aleksandra Stamenkovic, Grant N Pierce, Harold M Aukema
Oxylipins are a group of fatty acid metabolites generated via oxygenation of polyunsaturated fatty acids and are involved in processes such as inflammation, immunity, pain, vascular tone and coagulation. As a result, oxylipins are implicated in many conditions characterized by these processes including cardiovascular disease and aging. The best characterized oxylipins in relation to cardiovascular disease are derived from the ω-6 fatty acid arachidonic acid. These oxylipins generally increase inflammation, hypertension and platelet aggregation, although not universally...
August 11, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28775075/first-selective-12-lox-inhibitor-ml355-impairs-thrombus-formation-and-vessel-occlusion-in-vivo-with-minimal-effects-on-hemostasis
#15
Reheman Adili, Benjamin E Tourdot, Katherine Mast, Jennifer Yeung, John C Freedman, Abigail Green, Diane K Luci, Ajit Jadhav, Anton Simeonov, David J Maloney, Theodore R Holman, Michael Holinstat
OBJECTIVE: Adequate platelet reactivity is required for maintaining hemostasis. However, excessive platelet reactivity can also lead to the formation of occlusive thrombi. Platelet 12(S)-lipoxygenase (12-LOX), an oxygenase highly expressed in the platelet, has been demonstrated to regulate platelet function and thrombosis ex vivo, supporting a key role for 12-LOX in the regulation of in vivo thrombosis. However, the ability to pharmacologically target 12-LOX in vivo has not been established to date...
October 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28774820/identification-of-cyp443d1-cyp74-clan-of-nematostella-vectensis-as-a-first-cnidarian-epoxyalcohol-synthase-and-insights-into-its-catalytic-mechanism
#16
Yana Y Toporkova, Svetlana S Gorina, Fakhima K Mukhitova, Mats Hamberg, Tatyana M Ilyina, Lucia S Mukhtarova, Alexander N Grechkin
The CYP74 clan enzymes are responsible for the biosynthesis of numerous bioactive oxylipins in higher plants, some Proteobacteria, brown and green algae, and Metazoa. A novel putative CYP74 clan gene CYP443D1 of the starlet sea anemone (Nematostella vectensis, Cnidaria) has been cloned, and the properties of the corresponding recombinant protein have been studied in the present work. The recombinant CYP443D1 was incubated with the 9- and 13-hydroperoxides of linoleic and α-linolenic acids (9-HPOD, 13-HPOD, 9-HPOT, and 13-HPOT, respectively), as well as with the 9-hydroperoxide of γ-linolenic acid (γ-9-HPOT) and 15-hydroperoxide of eicosapentaenoic acid (15-HPEPE)...
October 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28772063/the-%C3%AF-3-fatty-acid-%C3%AE-linolenic-acid-extends-caenorhabditis-elegans-lifespan-via-nhr-49-ppar%C3%AE-and-oxidation-to-oxylipins
#17
Wenbo Qi, Gloria E Gutierrez, Xiaoli Gao, Hong Dixon, Joe A McDonough, Ann M Marini, Alfred L Fisher
The dietary intake of ω-3 polyunsaturated fatty acids has been linked to a reduction in the incidence of aging-associated disease including cardiovascular disease and stroke. Additionally, long-lived Caenorhabditis elegans glp-1 germ line-less mutant animals show a number of changes in lipid metabolism including the increased production of the ω-3 fatty acid, α-linolenic acid (ALA). Here, we show that the treatment of C. elegans with ALA produces a dose-dependent increase in lifespan. The increased longevity of the glp-1 mutant animals is known to be dependent on both the NHR-49/PPARα and SKN-1/Nrf2 transcription factors, although the mechanisms involved are incompletely understood...
October 2017: Aging Cell
https://www.readbyqxmd.com/read/28764653/maize-network-analysis-revealed-gene-modules-involved-in-development-nutrients-utilization-metabolism-and-stress-response
#18
Shisong Ma, Zehong Ding, Pinghua Li
BACKGROUND: The advent of big data in biology offers opportunities while poses challenges to derive biological insights. For maize, a large amount of publicly available transcriptome datasets have been generated but a comprehensive analysis is lacking. RESULTS: We constructed a maize gene co-expression network based on the graphical Gaussian model, using massive RNA-seq data. The network, containing 20,269 genes, assembles into 964 gene modules that function in a variety of plant processes, such as cell organization, the development of inflorescences, ligules and kernels, the uptake and utilization of nutrients (e...
August 1, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28736329/cord-blood-eicosanoid-signatures-and-newborn-gestational-age
#19
Sandra Gouveia-Figueira, Dries S Martens, Tim S Nawrot, Malin L Nording
Beyond prostaglandins, the function of eicosanoids and other oxylipins in pregnancy and labor is poorly understood. In contrast to earlier work focusing on preterm infants, we investigated how oxylipin levels in newborns (measured in cord blood) vary during the last weeks of pregnancy in 190 mother-newborns (≥37 weeks of gestation) of the ENVIRONAGE birth cohort, Belgium. We found increased levels of PGE2 (p=0.003), PGF2α (p=0.042), 8,9-DHET (p=0.037), 11-HETE (p=0.034), and 15-HETrE (p=0.008) associated with full term pregnancy compared to early term labor...
July 20, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28715485/characterization-of-the-maize-lipoxygenase-gene-family-in-relation-to-aflatoxin-accumulation-resistance
#20
Oluwaseun F Ogunola, Leigh K Hawkins, Erik Mylroie, Michael V Kolomiets, Eli Borrego, Juliet D Tang, W Paul Williams, Marilyn L Warburton
Maize (Zea mays L.) is a globally important staple food crop prone to contamination by aflatoxin, a carcinogenic secondary metabolite produced by the fungus Aspergillus flavus. An efficient approach to reduce accumulation of aflatoxin is the development of germplasm resistant to colonization and toxin production by A. flavus. Lipoxygenases (LOXs) are a group of non-heme iron containing dioxygenase enzymes that catalyze oxygenation of polyunsaturated fatty acids (PUFAs). LOX derived oxylipins play critical roles in plant defense against pathogens including A...
2017: PloS One
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