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https://www.readbyqxmd.com/read/28410667/comparative-effects-of-high-oleic-acid-vs-high-mixed-saturated-fatty-acid-obesogenic-diets-upon-pufa-metabolism-in-mice
#1
Matthew J Picklo, Joseph Idso, Drew R Seeger, Harold M Aukema, Eric J Murphy
Emerging evidence indicates that the fatty acid composition of obesogenic diets influences physiologic outcomes. There are scant data regarding how the content of non-essential fatty acids like monounsaturated fatty acids (MUFA) and saturated fatty acids (SFAs) impact the metabolism of polyunsaturated fatty acids (PUFAs). In this work, we tested the hypothesis that obesogenic diets enriched in oleic acid (OA; 18:1n-9) reduce polyunsaturated fatty acid (PUFA) levels vs an obesogenic diet enriched in SFAs. Adult male mice were fed for eight weeks either (1) a control 16% fat energy (en) diet with 5...
April 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28409336/dietary-docosahexaenoic-acid-and-trans-10-cis-12-conjugated-linoleic-acid-differentially-alter-oxylipin-profiles-in-mouse-periuterine-adipose-tissue
#2
Yuriko Adkins, Benjamin J Belda, Theresa L Pedersen, Dawn M Fedor, Bruce E Mackey, John W Newman, Darshan S Kelley
Diets containing high n-3 polyunsaturated fatty acids (PUFA) decrease inflammation and the incidence of chronic diseases including cardiovascular disease and nonalcoholic fatty liver disease while trans-fatty acids (TFA) intake increases the incidence of these conditions. Some health benefits of n-3 PUFA are mediated through the impact of their oxygenated metabolites, i.e. oxylipins. The TFA, trans-10, cis-12-conjugated linoleic acid (CLA; 18:2n-6) is associated with adipose tissue (AT) inflammation, oxidative stress, and wasting...
April 13, 2017: Lipids
https://www.readbyqxmd.com/read/28408661/multiomics-of-tomato-glandular-trichomes-reveals-distinct-features-of-central-carbon-metabolism-supporting-high-productivity-of-specialized-metabolites
#3
Gerd Balcke, Stefan Bennewitz, Nick Bergau, Benedikt Athmer, Anja Henning, Petra Majovsky, José M Jiménez-Gómez, Wolfgang Hoehenwarter, Alain F Tissier
Glandular trichomes are metabolic cell factories with the capacity to produce large quantities of secondary metabolites. Little is known about the connection between central carbon metabolism and metabolic productivity for secondary metabolites in glandular trichomes. To address this gap in our knowledge, we performed comparative metabolomics, transcriptomics, proteomics and 13C-labeling of type VI glandular trichomes and leaves from a cultivated (Solanum lycopersicum LA4024) and a wild (Solanum habrochaites LA1777) tomato accession...
April 13, 2017: Plant Cell
https://www.readbyqxmd.com/read/28390240/defense-and-signalling-metabolites-of-the-crucifer-erucastrum-canariense-synchronized-abiotic-induction-of-phytoalexins-and-galacto-oxylipins
#4
M Soledade C Pedras, Q Huy To
Erucastrum canariense Webb & Berthel. (Brassicaceae) is a wild crucifer that grows in rocky soils, in salt and water stressed habitats, namely in the Canary Islands and similar environments. Abiotic stress induced by copper chloride triggered formation of a phytoalexin and galacto-oxylipins in E. canariense, whereas wounding induced galacto-oxylipins but not phytoalexins. Analysis of the metabolite profiles of leaves of E. canariense followed by isolation and structure determination afforded the phytoalexin erucalexin, the phytoanticipin indolyl-3-acetonitrile, the galacto-oxylipins arabidopsides A, C, and D, and the oxylipin 12-oxophytodienoic acid...
April 5, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28380387/metabolite-quantification-by-nmr-and-lc-ms-ms-reveals-differences-between-unstimulated-stimulated-and-pure-parotid-saliva
#5
João Figueira, Sandra Gouveia-Figueira, Carina Öhman, Pernilla Lif Holgerson, Malin L Nording, Anders Öhman
Saliva is a readily available biofluid that is sensitive to metabolic changes and can be collected through rapid and non-invasive collection procedures, and it shows great promise for clinical metabolomic studies. This work studied the metabolite composition of, and the differences between, saliva samples collected by unstimulated spitting/drooling, paraffin chewing-stimulated spitting, and parotid gland suction using targeted nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) for metabolite quantification...
June 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28372151/quantification-of-phytoprostanes-bioactive-oxylipins-and-phenolic-compounds-of-passiflora-edulis-sims-shell-using-uhplc-qqq-ms-ms-and-lc-it-dad-ms-ms
#6
Sonia Medina, Jacinta Collado-González, Federico Ferreres, Julián Londoño-Londoño, Claudio Jiménez-Cartagena, Alexandre Guy, Thierry Durand, Jean-Marie Galano, Angel Gil-Izquierdo
The genus Passiflora, comprising about 500 species, is the largest in the Passion flower family. Passiflora edulis Sims f. edulis (gulupa) is one of the most important fruits cultivated in Colombia. In recent years and due to its organoleptic and bioactive properties, its exports have significantly increased. In this work, six new bioactive oxylipins -phytoprostanes - were detected in gulupa shell by a UHPLC-QqQ-MS/MS method: F1t-phytoprostanes and D1t-phytoprostanes were the predominant and minor classes, respectively...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28371855/enzymatic-and-non-enzymatic-mechanisms-contribute-to-lipid-oxidation-during-seed-aging
#7
Ayla Oenel, Agnes Fekete, Markus Krischke, Sophie C Faul, Gabriele Gresser, Michel Havaux, Martin J Mueller, Susanne Berger
Storage of seeds is accompanied by loss of germination and oxidation of storage and membrane lipids. A lipidomic analysis revealed that during natural and artificial aging of Arabidopsis seeds levels of several diacylglycerols and free fatty acids such as linoleic acid and linolenic acid as well as free oxidized fatty acids and oxygenated triacylglycerols increased. Lipids can be oxidized by enzymatic or non-enzymatic processes. In the enzymatic pathway, lipoxygenases catalyze the first oxygenation step of polyunsaturated fatty acids...
March 20, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28366879/proteomic-insight-into-the-mitigation-of-wheat-root-drought-stress-by-arbuscular-mycorrhizae
#8
Letizia Bernardo, Caterina Morcia, Paolo Carletti, Roberta Ghizzoni, Franz W Badeck, Fulvia Rizza, Luigi Lucini, Valeria Terzi
Arbuscular mycorrhizal fungi (AMF) are plant growth promoters that ameliorate plant-water relations and the nutrient uptake of wheat. In this work, two cultivars of Triticum spp., a bread and a durum wheat, grown under drought stress and inoculated or not by AMF, are evaluated through a shotgun proteomic approach. The AMF association had beneficial effects as compared to non-mycorrhizal roots, in both bread and durum wheat. The beneficial symbiosis was confirmed by measuring morphological and physiological traits...
March 30, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28357126/the-anti-inflammatory-compound-palmitoylethanolamide-inhibits-prostaglandin-and-hydroxyeicosatetraenoic-acid-production-by-a-macrophage-cell-line
#9
Linda Gabrielsson, Sandra Gouveia-Figueira, Jenny Häggström, Mireille Alhouayek, Christopher J Fowler
The anti-inflammatory agent palmitoylethanolamide (PEA) reduces cyclooxygenase (COX) activity in vivo in a model of inflammatory pain. It is not known whether the compound reduces prostaglandin production in RAW264.7 cells, whether such an action is affected by compounds preventing the breakdown of endogenous PEA, whether other oxylipins are affected, or whether PEA produces direct effects upon the COX-2 enzyme. RAW264.7 cells were treated with lipopolysaccharide and interferon-γ to induce COX-2. At the level of mRNA, COX-2 was induced >1000-fold following 24 h of the treatment...
April 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28337214/crystal-structure-of-the-chloroplastic-oxoene-reductase-ceqorh-from-arabidopsis-thaliana
#10
Sarah Mas Y Mas, Gilles Curien, Cécile Giustini, Norbert Rolland, Jean-Luc Ferrer, David Cobessi
Enzymatic and non-enzymatic peroxidation of polyunsaturated fatty acids give rise to accumulation of aldehydes, ketones, and α,β-unsaturated carbonyls of various lengths, known as oxylipins. Oxylipins with α,β-unsaturated carbonyls are reactive electrophile species and are toxic. Cells have evolved several mechanisms to scavenge reactive electrophile oxylipins and decrease their reactivity such as by coupling with glutathione, or by reduction using NAD(P)H-dependent reductases and dehydrogenases of various substrate specificities...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28328948/vascular-endothelial-overexpression-of-human-cyp2j2-tie2-cyp2j2-tr-modulates-cardiac-oxylipin-profiles-and-enhances-coronary-reactive-hyperemia-in-mice
#11
Ahmad Hanif, Matthew L Edin, Darryl C Zeldin, Christophe Morisseau, John R Falck, Mohammed A Nayeem
Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by cytochrome (CYP) P450 epoxygenases, and to ω-terminal hydroxyeicosatetraenoic acids (HETEs) by ω-hydroxylases. EETs and HETEs often have opposite biologic effects; EETs are vasodilatory and protect against ischemia/reperfusion injury, while ω-terminal HETEs are vasoconstrictive and cause vascular dysfunction. Other oxylipins, such as epoxyoctadecaenoic acids (EpOMEs), hydroxyoctadecadienoic acids (HODEs), and prostanoids also have varied vascular effects...
2017: PloS One
https://www.readbyqxmd.com/read/28319683/stereoselective-total-synthesis-of-oxylipin-from-open-chain-gluco-configured-building-block
#12
Santosh Ramdas Borkar, Indrapal Singh Aidhen
Total synthesis of naturally occurring Oxylipin has been achieved from open chain gluco-configured building block which is readily assembled from inexpensive and commercially available D-(+)-gluconolactone. Grignard reaction and Wittig olefination reactions are key steps for the requisite CC bond formation.
March 3, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28314621/docosahexaenoic-acid-dha-an-essential-nutrient-and-a-nutraceutical-for-brain-health-and-diseases
#13
REVIEW
Grace Y Sun, Agnes Simonyi, Kevin L Fritsche, Dennis Y Chuang, Mark Hannink, Zezong Gu, C Michael Greenlief, Jeffrey K Yao, James C Lee, David Q Beversdorf
Docosahexaenoic acid (DHA), a polyunsaturated fatty acid (PUFA) enriched in phospholipids in the brain and retina, is known to play multi-functional roles in brain health and diseases. While arachidonic acid (AA) is released from membrane phospholipids by cytosolic phospholipase A2 (cPLA2), DHA is linked to action of the Ca(2+)-independent iPLA2. DHA undergoes enzymatic conversion by 15-lipoxygenase (Alox 15) to form oxylipins including resolvins and neuroprotectins, which are powerful lipid mediators. DHA can also undergo non-enzymatic conversion by reacting with oxygen free radicals (ROS), which cause the production of 4-hydoxyhexenal (4-HHE), an aldehyde derivative which can form adducts with DNA, proteins and lipids...
March 10, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28303390/the-hydroperoxide-lyase-branch-of-the-oxylipin-pathway-protects-against-photoinhibition-of-photosynthesis
#14
Tatyana Savchenko, Denis Yanykin, Andrew Khorobrykh, Vasily Terentyev, Vyacheslav Klimov, Katayoon Dehesh
This study describes a new role for hydroperoxide lyase branch of oxylipin biosynthesis pathway in protecting photosynthetic apparatus under high light conditions. Lipid-derived signaling molecules, oxylipins, produced by a multi-branch pathway are central in regulation of a wide range of functions. The two most known branches, allene oxide synthase (AOS) and 13-hydroperoxide lyase (HPL) pathways, are best recognized as producers of defense compounds against biotic challenges. In the present work, we examine the role of these two oxylipin branches in plant tolerance to the abiotic stress, namely excessive light...
March 16, 2017: Planta
https://www.readbyqxmd.com/read/28270686/two-new-sacrolide-class-oxylipins-from-the-edible-cyanobacterium-aphanothece-sacrum
#15
Naoya Oku, Sayaka Hana, Miyako Matsumoto, Kohsuke Yonejima, Keijiroh Tansei, Yasuhiro Isogai, Yasuhiro Igarashi
No abstract text is available yet for this article.
March 8, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28259546/who-is-the-real-12-hetre
#16
REVIEW
Jennifer Yeung, Michael Holinstat
Oxygenases, including lipoxygenases and cytochrome P450s, generate an array of structurally diverse oxylipins that modulate distinct biological responses in mammals. Depending on the source of tissues and enzymes, distinct oxylipins are generated with inherent cellular function. Here, we report structurally different forms of 12-HETrE, with distinct biological function in tissues as well as their derived enzymatic source.
March 1, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28259037/altered-soluble-epoxide-hydrolase-derived-oxylipins-in-patients-with-seasonal-major-depression-an-exploratory-study
#17
Marie Hennebelle, Yurika Otoki, Jun Yang, Bruce D Hammock, Anthony J Levitt, Ameer Y Taha, Walter Swardfager
Many cytochrome p450-derived lipids promote resolution of inflammation, in contrast to their soluble epoxide hydrolase(sEH)-derived oxylipin breakdown products. Here we compare plasma oxylipins and precursor fatty acids between seasons in participants with major depressive disorder with seasonal pattern (MDD-s). Euthymic participants with a history of MDD-s recruited in summer-fall were followed-up in winter. At both visits, a structured clinical interview (DSM-5 criteria) and the Beck Depression Inventory II (BDI-II) were administered...
February 27, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28253346/herbivore-induced-chemical-and-molecular-responses-of-the-kelps-laminaria-digitata-and-lessonia-spicata
#18
Andrés Ritter, Léa Cabioch, Loraine Brillet-Guéguen, Erwan Corre, Audrey Cosse, Laurence Dartevelle, Harold Duruflé, Carina Fasshauer, Sophie Goulitquer, François Thomas, Juan A Correa, Philippe Potin, Sylvain Faugeron, Catherine Leblanc
Kelps are founding species of temperate marine ecosystems, living in intertidal coastal areas where they are often challenged by generalist and specialist herbivores. As most sessile organisms, kelps develop defensive strategies to restrain grazing damage and preserve their own fitness during interactions with herbivores. To decipher some inducible defense and signaling mechanisms, we carried out metabolome and transcriptome analyses in two emblematic kelp species, Lessonia spicata from South Pacific coasts and Laminaria digitata from North Atlantic, when challenged with their main specialist herbivores...
2017: PloS One
https://www.readbyqxmd.com/read/28235994/mass-spectrometry-profiling-of-oxylipins-endocannabinoids-and-n-acylethanolamines-in-human-lung-lavage-fluids-reveals-responsiveness-of-prostaglandin-e2-and-associated-lipid-metabolites-to-biodiesel-exhaust-exposure
#19
Sandra Gouveia-Figueira, Masoumeh Karimpour, Jenny A Bosson, Anders Blomberg, Jon Unosson, Jamshid Pourazar, Thomas Sandström, Annelie F Behndig, Malin L Nording
The adverse effects of petrodiesel exhaust exposure on the cardiovascular and respiratory systems are well recognized. While biofuels such as rapeseed methyl ester (RME) biodiesel may have ecological advantages, the exhaust generated may cause adverse health effects. In the current study, we investigated the responses of bioactive lipid mediators in human airways after biodiesel exhaust exposure using lipidomic profiling methods. Lipid mediator levels in lung lavage were assessed following 1-h biodiesel exhaust (average particulate matter concentration, 159 μg/m(3)) or filtered air exposure in 15 healthy individuals in a double-blinded, randomized, controlled, crossover study design...
April 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28215784/comparison-of-derivatization-ionization-techniques-for-liquid-chromatography-tandem-mass-spectrometry-analysis-of-oxylipins
#20
Sven W Meckelmann, Stefan Hellhake, Maryvonne Steuck, Michael Krohn, Nils Helge Schebb
The performance of two derivatization and ionization techniques for the quantitative reversed phase liquid chromatography (LC)- mass spectrometry (MS) analysis of hydroxy fatty acids (OH-PUFA) in plasma was evaluated: One used AMPP (N-(4-aminomethylphenyl)pyridinium chloride) leading to a positive charged amid-derivate which can be detected by electrospray ionization (ESI)-MS. Second yielded penta fluorobenzyl bromide (PFB) ester derivates allowing detection in electron capture atmospheric pressure chemical ionization (ecAPCI)-MS...
February 17, 2017: Prostaglandins & Other Lipid Mediators
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