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https://www.readbyqxmd.com/read/29666162/two-abscisic-acid-responsive-plastid-lipase-genes-involved-in-jasmonic-acid-biosynthesis-in-arabidopsis-thaliana
#1
Kun Wang, Qiang Guo, John E Froehlich, Hope Lynn Hersh, Agnieszka Zienkiewicz, Gregg A Howe, Christoph Benning
Chloroplast membranes with their unique lipid composition are crucial for photosynthesis. Maintenance of the chloroplast membranes requires finely tuned lipid anabolic and catabolic reactions. Despite the presence of a large number of predicted lipid-degrading enzymes in the chloroplasts, their biological functions remain largely unknown. Recently, we described PLASTID LIPASE1 (PLIP1), a plastid phospholipase A1 that contributes to seed oil biosynthesis. The Arabidopsis thaliana genome encodes two putative PLIP1 paralogs, which we designated PLIP2 and PLIP3...
April 17, 2018: Plant Cell
https://www.readbyqxmd.com/read/29665957/hydrogen-rich-water-mediates-redox-regulation-of-the-antioxidant-system-mycelial-regeneration-and-fruiting-body-development-in-hypsizygus-marmoreus
#2
Hui Chen, Haibo Hai, Hong Wang, Qian Wang, Mingjie Chen, Zhiyong Feng, Ming Ye, Jinjing Zhang
Hypsizygus marmoreus is an important industrialized mushroom, yet the lack of basic research on this fungus has hindered further development of its economic value. In this study, mycelia injured by scratching were treated with hydrogen-rich water (HRW) to investigate the involvement of the redox system in fruiting body development. Compared to the control group, damaged mycelia treated with HRW regenerated earlier and showed significantly enhanced fruiting body production. Antioxidant capacity increased significantly in damaged mycelia after HRW treatment, as indicated by higher antioxidant enzyme activities and antioxidant contents; the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) were also reduced at the mycelial regeneration stage after treatment with HRW...
May 2018: Fungal Biology
https://www.readbyqxmd.com/read/29660236/oxylipins-from-both-pathogen-and-host-antagonize-ja-mediated-defense-via-the-9-lipoxygenase-pathway-in-fusarium-vertcillioides-infection-of-maize
#3
Paola Battilani, Alessandra Lanubile, Valeria Scala, Massimo Reverberi, Rossella Gregori, Claudia Falavigna, Chiara Dall'Asta, Yong-Soon Park, John Bennett, Eli J Borrego, Michael V Kolomiets
Oxylipins are a newly emerging group of signals that serve either defense roles or promote virulence. To identify specific host and fungal genes and oxylipins governing the interactions between maize and Fusarium verticillioides, maize wild-type and lipoxygenase3 (lox3) mutant were inoculated with either F. verticillioides wild-type or linoleate-diol-synthase 1-deleted mutant (ΔFvlds1D). Results showed that lox3 mutants were more resistant to F. verticillioides. The reduced colonization on lox3 was associated with reduced fumonisin production and with a stronger and earlier induction of ZmLOX4, ZmLOX5, and ZmLOX12...
April 16, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29618786/toxigenic-effects-of-two-benthic-diatoms-upon-grazing-activity-of-the-sea-urchin-morphological-metabolomic-and-de-novo-transcriptomic-analysis
#4
Nadia Ruocco, Susan Costantini, Valerio Zupo, Chiara Lauritano, Davide Caramiello, Adrianna Ianora, Alfredo Budillon, Giovanna Romano, Genoveffa Nuzzo, Giuliana D'Ippolito, Angelo Fontana, Maria Costantini
Diatoms are unicellular algae playing a key role as photosynthetic organisms in the world's ocean food webs. The chemical ecology of planktonic diatoms is well documented, but few studies have reported on the effects of benthic diatoms on their consumers, also due to difficulties in the collection, quantification and massive culturing of benthic species. Here for the first time we investigate the effects of feeding on two abundantly occurring benthic diatoms, Nanofrustulum shiloi and Cylindrotheca closterium, isolated from the leaves of the seagrass Posidonia oceanica, on the sea urchin Paracentrotus lividus...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29605135/mass-spectrometry-profiling-reveals-altered-plasma-levels-of-monohydroxy-fatty-acids-and-related-lipids-in-healthy-humans-after-controlled-exposure-to-biodiesel-exhaust
#5
Sandra Gouveia-Figueira, Masoumeh Karimpour, Jenny A Bosson, Anders Blomberg, Jon Unosson, Maria Sehlstedt, Jamshid Pourazar, Thomas Sandström, Annelie F Behndig, Malin L Nording
Experimental human exposure studies are an effective tool to study adverse health effects from acute inhalation of particulate matter and other constituents of air pollution. In this randomized and double-blinded crossover study, we investigated the systemic effect on bioactive lipid metabolite levels after controlled biodiesel exhaust exposure of healthy humans and compared it to filtered air at a separate exposure occasion. Eicosanoids and other oxylipins, as well as endocannabinoids and related lipids, were quantified in plasma from 14 healthy volunteers at baseline and at three subsequent time points (2, 6, and 24 h) after 1 h exposure sessions...
August 14, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29599523/grazer-induced-transcriptomic-and-metabolomic-response-of-the-chain-forming-diatom-skeletonema-marinoi
#6
Alberto Amato, Valeria Sabatino, Göran M Nylund, Johanna Bergkvist, Swaraj Basu, Mats X Andersson, Remo Sanges, Anna Godhe, Thomas Kiørboe, Erik Selander, Maria I Ferrante
Diatoms and copepods are main actors in marine food webs. The prey-predator interactions between them affect bloom dynamics, shape marine ecosystems and impact the energy transfer to higher trophic levels. Recently it has been demonstrated that the presence of grazers may affect the diatom prey beyond the direct effect of grazing. Here, we investigated the response of the chain-forming centric diatom Skeletonema marinoi to grazer cues, including changes in morphology, gene expression and metabolic profile. S...
March 29, 2018: ISME Journal
https://www.readbyqxmd.com/read/29580528/sorting-out-the-phytoprostane-and-phytofuran-profile-in-vegetable-oils
#7
Raúl Domínguez-Perles, Ángel Abellán, Daniel León, Federico Ferreres, Alexander Guy, Camille Oger, Jean Marie Galano, Thierry Durand, Ángel Gil-Izquierdo
Phytoprostanes (PhytoPs) and phytofurans (PhytoFs) are prostaglandin-like compounds, contributing to defense signaling and prevention of cellular damage. These plant oxylipins result from autoxidation of α-linolenic acid (ALA) and have been proposed as new bioactive compounds due to their structural analogies with isoprostanes (IsoPs) and prostanoids derived from arachidonic acid in mammals, which have demonstrated diverse biological activities. The present work assesses a wide range of vegetable oils - including extra virgin olive oils (n = 7) and flax, sesame, argan, safflower seed, grapeseed, and palm oils - for their content of PhytoPs and PhytoFs...
May 2018: Food Research International
https://www.readbyqxmd.com/read/29555680/aberrant-fatty-acid-metabolism-in-skeletal-muscle-contributes-to-insulin-resistance-in-zinc-transporter-7-znt7-knockout-mice
#8
Liping Huang, Surapun Tepaamorndech, Catherine P Kirschke, John W Newman, William R Keyes, Theresa L Pedersen, Jureeporn Dumnil
ZnT7 (Slc30a7) is a widely expressed zinc transporter involved in sequestration of zinc into the Golgi apparatus and vesicular compartments. Znt7-knockout (KO) mice are mildly zinc deficient and lean. Despite their lean phenotype, adult male Znt7-KO mice are prone to insulin resistance. We hypothesized that fat partitioning from adipose to non-adipose tissues causes insulin resistance in Znt7-KO mice. Here, we used biological and biochemical methods including fatty acid and oxylipin profiling, electron microscopy, immunohistochemistry, quantitative RT-PCR, and Western blot analysis to identify the underlying mechanism of insulin resistance in Znt7-KO mice...
March 19, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29547355/root-exudates-of-stressed-plants-stimulate-and-attract-trichoderma-soil-fungi
#9
Nadia Lombardi, Stefania Vitale, David Turrà, Massimo Reverberi, Corrado Fanelli, Francesco Vinale, Roberta Marra, Michelina Ruocco, Alberto Pascale, Giada d'Errico, Sheridan Lois Woo, Matteo Lorito
Plant roots release complex mixtures of bioactive molecules including compounds that affect the activity and modify the composition of the rhizosphere microbiome. In this work, we investigated the initial phase of the interaction between tomato and an effective biocontrol strain of Trichoderma harzianum (T22). We found that root exudates (RE), obtained from plants grown in a split root system and exposed to a choice of biotic and abiotic stress factors (wounding, salt, pathogen attack), stimulate the growth and act as chemoattractants of the biocontrol fungus...
March 16, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29499090/arabidopsis-non-responding-to-oxylipins-locus-noxy7-encodes-a-yeast-gcn1-homolog-that-mediates-non-canonical-translation-regulation-and-stress-adaptation
#10
Yovanny Izquierdo, Satish Kulasekaran, Pablo Benito, Bran López, Ruth Marcos, Tomás Cascón, Mats Hamberg, Carmen Castresana
Stress adaptation and translational regulation was studied using noxy7 (non-responding to oxylipins7) from a series of Arabidopsis thaliana mutants. We identified the noxy7 mutation in At1g64790, which encodes a homolog of the yeast translational regulator GENERAL CONTROL NON-DEREPRESSIBLE1 (GCN1) that activates the GCN2 kinase; GCN2 in turn phosphorylates the α subunit of the translation initiation factor eIF2. This regulatory circuit is conserved in yeast and mammals, in which phosphorylated eIF2α (P-eIF2α) facilitates stress adaptation by inhibiting protein synthesis...
March 2, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29487344/a-metabolomics-study-of-qiliqiangxin-in-a-rat-model-of-heart-failure-a-reverse-pharmacology-approach
#11
Junzeng Fu, Liping Chang, Amy C Harms, Zhenhua Jia, Hongtao Wang, Cong Wei, Li Qiao, Shuyan Tian, Thomas Hankemeier, Yiling Wu, Mei Wang
The Chinese medicine Qiliqiangxin (QL) has been shown to have a protective role in heart failure. Here, we explore the underlying working mechanism of the key therapeutic component in QL using a rat model of heart failure. Heart failure after myocardial infarction was induced surgically and confirmed using echocardiography; a separate group of rats underwent sham surgery. The rats with heart failure were randomly assigned to receive QL, the angiotensin-converting enzyme inhibitor benazepril, or placebo groups...
February 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29482766/distinct-effects-of-dietary-ala-epa-and-dha-on-rat-adipose-oxylipins-vary-by-depot-location-and-sex
#12
Anne M Mendonça, Lucien G J Cayer, Samantha D Pauls, Tanja Winter, Shan Leng, Carla G Taylor, Peter Zahradka, Harold M Aukema
Dietary EPA and DHA given together alter oxylipins in adipose tissue. To compare the separate effects of individual dietary n-3 PUFA on oxylipins in different adipose depots (gonadal, mesenteric, perirenal, subcutaneous) in males and females, rats were provided diets containing higher levels of α-linolenic acid (ALA), EPA or DHA. Each n-3 PUFA enhanced its respective oxylipins the most, while effects on other n-3 oxylipins varied. For example: in perirenal and subcutaneous depots, more DHA oxylipins were higher with dietary ALA than with EPA; dietary EPA uniquely decreased 14-hydroxy-docosahexaenoic acid, in contrast to increasing many other DHA oxylipins...
February 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29459911/effects-of-a-12-week-high-%C3%AE-linolenic-acid-intervention-on-epa-and-dha-concentrations-in-red-blood-cells-and-plasma-oxylipin-pattern-in-subjects-with-a-low-epa-and-dha-status
#13
Theresa Greupner, Laura Kutzner, Fabian Nolte, Alena Strangmann, Heike Kohrs, Andreas Hahn, Nils Helge Schebb, Jan Philipp Schuchardt
The essential omega-3 fatty acid alpha-linolenic acid (ALA, 18:3n3) can be converted into EPA and DHA. The aim of the present study was to determine the effect of a high-ALA diet on EPA and DHA levels in red blood cells (RBCs) and their oxylipins in the plasma of subjects with a low EPA and DHA status. Fatty acid concentrations [μg mL-1 ] and relative amounts [% of total fatty acids] in the RBCs of 19 healthy men (mean age 26.4 ± 4.6 years) were analyzed by means of GC-FID. Free plasma oxylipin concentrations were determined by LC-MS based targeted metabolomics...
February 20, 2018: Food & Function
https://www.readbyqxmd.com/read/29448090/uhplc-qtof-ms-analysis-of-bioactive-constituents-from-two-romanian-goji-lycium-barbarum-l-berries-cultivars-and-their-antioxidant-enzyme-inhibitory-and-real-time-cytotoxicological-evaluation
#14
Andrei Mocan, Cadmiel Moldovan, Gökhan Zengin, Onur Bender, Marcello Locatelli, Mario Simirgiotis, Arzu Atalay, Dan C Vodnar, Sascha Rohn, Gianina Crișan
Goji (Lycium barbarum L.) berries are emphasized as healthy food or are used widely as dietary supplements. In the present study, the antioxidant and enzyme inhibitory activities of berries extracts from two selected Romanian cultivars (cv. Erma and cv. Biglifeberry) have been evaluated. UHPLC-QTOF-MS analysis results revealed the presence of vitamin C and related compounds, phenolic acids, flavonoids, fatty acids (oxylipins), and spermidine derivatives. In particular, cv. Erma showed a strong tyrosinase-inhibitory effect, whereas cv...
February 12, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29422909/depletion-of-arabidopsis-acyl-coa-binding-protein3-affects-fatty-acid-composition-in-the-phloem
#15
Tai-Hua Hu, Shiu-Cheung Lung, Zi-Wei Ye, Mee-Len Chye
Oxylipins are crucial components in plant wound responses that are mobilised via the plant vasculature. Previous studies have shown that the overexpression of an Arabidopsis acyl-CoA-binding protein, AtACBP3, led to an accumulation of oxylipin-containing galactolipids, and AtACBP3pro::BETA-GLUCURONIDASE (GUS) was expressed in the phloem of transgenic Arabidopsis. To investigate the role of AtACBP3 in the phloem, reverse transcription-polymerase chain reaction and western blot analysis of phloem exudates from the acbp3 mutant and wild type revealed that the AtACBP3 protein, but not its mRNA, was detected in the phloem sap...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29413356/abnormal-lipoprotein-oxylipins-in-metabolic-syndrome-and-partial-correction-by-omega-3-fatty-acids
#16
Gregory C Shearer, Kamil Borkowski, Susan L Puumala, William S Harris, Theresa L Pedersen, John W Newman
Metabolic syndrome (MetSyn) is characterized by chronic inflammation which mediates the associated high risk for cardiovascular and other diseases. Oxylipins are a superclass of lipid mediators with potent bioactivities in inflammation, vascular biology, and more. While their role as locally produced agents is appreciated, most oxylipins in plasma are found in lipoproteins suggesting defective regulation of inflammation could be mediated by the elevated VLDL and low HDL levels characteristic of MetSyn. Our objective was to compare the oxylipin composition of VLDL, LDL, and HDL in 14 optimally healthy individuals and 31 MetSyn patients, and then to determine the effects of treating MetSyn subjects with 4g/day of prescription omega-3 fatty acids (P-OM3) on lipoprotein oxylipin profiles...
January 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29407524/metabolic-inflammatory-vascular-comorbidity-in-psychiatric-disorders-soluble-epoxide-hydrolase-seh-as-a-possible-new-target
#17
REVIEW
W Swardfager, M Hennebelle, D Yu, B D Hammock, A J Levitt, K Hashimoto, A Y Taha
The common and severe psychiatric disorders, including major depressive disorder (MDD) and bipolar disorder (BD), are associated with inflammation, oxidative stress and changes in peripheral and brain lipid metabolism. Those pathways are implicated in the premature development of vascular and metabolic comorbidities, which account for considerable morbidity and mortality, including increased dementia risk. During endoplasmic reticulum stress, the soluble epoxide hydrolase (sEH) enzyme converts anti-inflammatory fatty acid epoxides generated by cytochrome p450 enzymes into their corresponding and generally less anti-inflammatory, or even pro-inflammatory, diols, slowing the resolution of inflammation...
April 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29385065/breast-milk-lipidome-is-associated-with-early-growth-trajectory-in-preterm-infants
#18
Marie-Cécile Alexandre-Gouabau, Thomas Moyon, Véronique Cariou, Jean-Philippe Antignac, El Mostafa Qannari, Mikaël Croyal, Mohamed Soumah, Yann Guitton, Agnès David-Sochard, Hélène Billard, Arnaud Legrand, Cécile Boscher, Dominique Darmaun, Jean-Christophe Rozé, Clair-Yves Boquien
Human milk is recommended for feeding preterm infants. The current pilot study aims to determine whether breast-milk lipidome had any impact on the early growth-pattern of preterm infants fed their own mother's milk. A prospective-monocentric-observational birth-cohort was established, enrolling 138 preterm infants, who received their own mother's breast-milk throughout hospital stay. All infants were ranked according to the change in weight Z-score between birth and hospital discharge. Then, we selected infants who experienced "slower" (n = 15, -1...
January 31, 2018: Nutrients
https://www.readbyqxmd.com/read/29343538/impact-of-dietary-%C3%AF-3-polyunsaturated-fatty-acid-supplementation-on-brown-and-brite-adipocyte-function
#19
Rayane A Ghandour, Cecilia Colson, Maude Giroud, Stefanie Maurer, Samah Rekima, Gerard P Ailhaud, Martin Klingenspor, Ez-Zoubir Amri, Didier F Pisani
The recent characterization of functional brown adipose tissue (BAT) in adult humans has opened new perspectives for regulation of energy expenditure with respect to obesity and diabetes. Furthermore, dietary recommendations have taken into account the insufficient dietary intake of ω3 polyunsaturated fatty acids (PUFA) and the concomitant excessive intake of ω6 PUFA associated with the occurrence of overweight/obesity. We aimed to study whether ω3 PUFAs could play a role in the recruitment and function of energy-dissipating brown/brite adipocytes...
January 17, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29330904/testing-a-chemical-series-inspired-by-plant-stress-oxylipin-signalling-agents-for-herbicide-safening-activity
#20
Melissa Brazier-Hicks, Kathryn M Knight, Jonathan D Sellars, Patrick G Steel, Robert Edwards
BACKGROUND: Herbicide safening in cereals is linked to a rapid xenobiotic response (XR), involving the induction of glutathione transferases (GSTs). The XR is also invoked by oxidized fatty acids (oxylipins) released during plant stress, suggesting a link between these signalling agents and safening. To examine this relationship, a series of compounds modelled on the oxylipins 12-oxophytodienoic acid and phytoprostane 1, varying in lipophilicity and electrophilicity, were synthesized...
April 2018: Pest Management Science
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