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https://www.readbyqxmd.com/read/28063801/effect-of-mid-follicular-phase-recombinant-lh-versus-urinary-hcg-supplementation-in-poor-ovarian-responders-undergoing-ivf-a-prospective-double-blinded-randomized-study
#1
Sze Man Jennifer Mak, Wai Yee Wong, Hoi Sze Chung, Pui Wah Chung, Grace Wing Shan Kong, Tin Chiu Li, Lai Ping Cheung
Luteinizing hormone (LH) is crucial for the development of follicular growth and oocyte maturation, especially in the management of poor ovarian responders (PORs). This study presents the results of a prospective double-blinded randomized study to compare the effect of mid-follicular phase recombinant LH (rLH) supplementation with urinary human chorionic gonadotrophin (uHCG) supplementation when using a fixed gonadotrophin-releasing hormone (GnRH) antagonist protocol in IVF cycles. A total of 49 women with poor ovarian response (POR) according to the Bologna criteria were recruited...
December 16, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28062641/melatonin-levels-in-follicular-fluid-as-markers-for-ivf-outcomes-and-predicting-ovarian-reserve
#2
Jing Tong, Shi-le Sheng, Yun Sun, Huihui Li, Wei-Ping Li, Cong Zhang, Zijiang Chen
Good-quality oocytes are critical for the success of in vitro fertilization (IVF), but, to date, there is no marker of ovarian reserve available that can accurately predict oocyte quality. Melatonin exerts its antioxidant actions as a strong radical scavenger that might affect oocyte quality directly, since it is the most potent antioxidant in follicular fluid. To investigate the precise role of endogenous melatonin in IVF outcomes, we recruited 61 women undergoing treatment cycles of IVF or intracytoplasmic sperm injection (ICSI) procedures and classified them into three groups according to their response to ovarian stimulation...
January 6, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28050963/live-births-after-polar-body-biopsy-and-frozen-thawed-cleavage-stage-embryo-transfer-case-report
#3
Fernando Guimarães, Matheus Roque, Marcello Valle, Alessandra Kostolias, Rodrigo A de Azevedo, Ciro D Martinhago, Marcos Sampaio, Selmo Geber
Pre-implantation genetic diagnosis (PGD) or screening (PGS) technology, has emerged and developed in the past few years, benefiting couples as it allows the selection and transfer of healthy embryos during IVF treatments. These techniques can be performed in oocytes (polar-body biopsy) or embryos (blastomere or trophectoderm biopsy). In this case report, we describe the first two live births to be published in Brazil after a polar-body (PB) biopsy. In case 1, a 42-year-old was submitted to PB biopsy with PGS due to advanced maternal age and poor ovarian reserve...
December 1, 2016: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/27990625/in-vitro-fertilization-health-care-professionals-generally-underestimate-patients-satisfaction-with-quality-of-care
#4
Herborg Holter, Ann-Louise Gejervall, Kia Borg, Ann-Kristin Sandin Bojö, Matts Wikland, Bodil Wilde Larsson, Christina Bergh
INTRODUCTION: Previous studies have mainly compared professionals' and patient's ratings of the importance of different care aspects, finding poor agreement between the groups concerning patient-centered quality of care. There is still little known about the professionals' knowledge of how patients' experience the quality of care they receive during in vitro fertilization (IVF) treatments. The aim of this study was to investigate how IVF health care professionals estimate patients' experience of patient-centered quality of care and if certain factors influenced the IVF professionals' perceptions and IVF patients' experience of quality of care...
December 19, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27976974/predictive-values-of-anti-m%C3%A3-llerian-hormone-antral-follicle-count-and-ovarian-response-prediction-index-orpi-for-assisted-reproductive-technology-outcomes
#5
Mahnaz Ashrafi, Mandana Hemat, Arezoo Arabipoor, Reza Salman Yazdi, Akram Bahman-Abadi, Rezvaneh Cheraghi
This prospective study was performed from June 2012 to June 2014 at Royan Institute to compare the predictive values of serum anti-müllerian hormone (AMH), antral follicle count (AFC) and ovarian response prediction index (ORPI) ([AFC × AMH]/age) for in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) cycle outcomes. Five hundred and fifty women included in the study with male factor and unexplained infertility were the first candidates for IVF/ICSI cycles. Serum AMH level was measured by a commercial ELISA kit and AFC was calculated by a transvaginal ultrasonography on day 2-3 of the menstrual cycle before starting ovarian stimulation...
December 15, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27932550/spermaurin-an-la1-like-peptide-from-the-venom-of-the-scorpion-scorpio-maurus-palmatus-improves-sperm-motility-and-fertilization-in-different-mammalian-species
#6
Guillaume Martinez, Jean-Pascal Hograindleur, Sébastien Voisin, Roland Abi Nahed, Tarek M Abd El Aziz, Jessica Escoffier, Julien Bessonnat, Claire-Maëlle Fovet, Michel De Waard, Sylviane Hennebicq, Vincent Aucagne, Pierre F Ray, Eric Schmitt, Philippe Bulet, Christophe Arnoult
STUDY QUESTION: Is it possible to identify original compounds that are able to enhance sperm motility from the venom of the scorpion Scorpio maurus palmatus? SUMMARY ANSWER: We identified a potent disulfide-rich peptide (DRP) of 73 amino acids that significantly improved the motility of fresh and frozen-thawed sperm in different mammalian species, including human, and improved fertilization outcome in mouse IVF experiments. WHAT IS KNOWN ALREADY: Any disturbance of sperm motility has a strong impact on fertilization and can lead to subfertility or infertility...
December 8, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27912901/individualized-versus-conventional-ovarian-stimulation-for-in%C3%A2-vitro-fertilization-a-multicenter-randomized-controlled-assessor-blinded-phase-3-noninferiority-trial
#7
Anders Nyboe Andersen, Scott M Nelson, Bart C J M Fauser, Juan Antonio García-Velasco, Bjarke M Klein, Joan-Carles Arce
OBJECTIVE: To compare the efficacy and safety of follitropin delta, a new human recombinant FSH with individualized dosing based on serum antimüllerian hormone (AMH) and body weight, with conventional follitropin alfa dosing for ovarian stimulation in women undergoing IVF. DESIGN: Randomized, multicenter, assessor-blinded, noninferiority trial (ESTHER-1). SETTING: Reproductive medicine clinics. PATIENT(S): A total of 1,329 women (aged 18-40 years)...
November 22, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27836979/a-mild-ovarian-stimulation-strategy-in-women-with-poor-ovarian-reserve-undergoing-ivf-a-multicenter-randomized-non-inferiority-trial
#8
M A Youssef, M van Wely, H Al-Inany, T Madani, N Jahangiri, S Khodabakhshi, M Alhalabi, M Akhondi, S Ansaripour, R Tokhmechy, L Zarandi, A Rizk, M El-Mohamedy, E Shaeer, M Khattab, M H Mochtar, F van der Veen
STUDY QUESTION: In subfertile women with poor ovarian reserve undergoing IVF does a mild ovarian stimulation strategy lead to comparable ongoing pregnancy rates in comparison to a conventional ovarian stimulation strategy? SUMMARY ANSWER: A mild ovarian stimulation strategy in women with poor ovarian reserve undergoing IVF leads to similar ongoing pregnancy rates as a conventional ovarian stimulation strategy. WHAT IS KNOWN ALREADY: Women diagnosed with poor ovarian reserve are treated with a conventional ovarian stimulation strategy consisting of high-dose gonadotropins and pituitary downregulation with a long mid-luteal start GnRH-agonist protocol...
January 2017: Human Reproduction
https://www.readbyqxmd.com/read/27684542/protection-of-cumulus-cells-following-dehydroepiandrosterone-supplementation
#9
Li-Te Lin, Peng-Hui Wang, San-Nung Chen, Chia-Jung Li, Zhi-Hong Wen, Jiin-Tsuey Cheng, Kuan-Hao Tsui
BACKGROUND: Growing studies have demonstrated that dehydroepiandrosterone (DHEA) may improve fertility outcomes in poor ovarian responders (PORs). The aim of this study was to compare clinical outcomes and cumulus cell (CC) expression before and after DHEA treatment in PORs undergoing in vitro fertilization (IVF) cycles. METHODS: Six patients with poor ovarian response were enrolled in the study according to Bologna criteria. DHEA was supplied at least 2 months before patients entered into the next IVF cycle...
August 12, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27682145/pre-implantation-genetic-screening-techniques-implications-for-clinical-prenatal-diagnosis
#10
Stefan C Kane, Elissa Willats, Sammya Bezerra Maia E Holanda Moura, Jonathan Hyett, Fabrício da Silva Costa
Chromosomal aneuploidy is responsible for a significant proportion of pregnancy failures, whether conceived naturally or through in vitro fertilization (IVF). In an effort to improve the success rate of IVF, screening embryos for aneuploidy - or pre-implantation genetic screening (PGS) - has been proposed as a means of ensuring only euploid embryos are selected for transfer. Early PGS approaches were based on fluorescence in situ hybridization testing, and have been shown not to improve live birth rates. Recent developments in genetic testing technologies - such as next-generation sequencing and quantitative polymerase chain reaction, coupled with embryo biopsy at the blastocyst stage - have shown promise in improving IVF outcomes, but they remain to be validated in adequately powered, prospective randomized trials...
2016: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/27627604/endometriosis-has-no-negative-impact-on-outcomes-of-in-vitro-fertilisation-in-women-with-poor-ovarian-response
#11
X Yang, R Huang, M Cai, X Liang
OBJECTIVE: To compare the in vitro fertilisation (IVF) outcomes of poor ovarian responders among women with laparoscopically diagnosed minimal-mild endometriosis (Group A), moderate-severe endometriosis (Group B) and those without endometriosis (Group C). The comparisons were made separately for age groups younger than 35 years and 35 years or older. DESIGN: Retrospective study. SETTING: A university-affiliated hospital in Guangzhou, China...
September 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27575500/basal-follicle-stimulating-hormone-level-correlated-to-age-is-a-good-prognostic-criterion-for-the-outcome-of-intracytoplasmic-sperm-microinjection
#12
Moez Kdous, Ghaya Merdassi, Fethi Zhioua, Hanène Elloumi, Khadija Kacem, Amel Zhioua
BACKGROUND: Age and increased FSH serum level in women are prognosis criteriae associated with decreased fertility. OBJECTIVE: The aim of this study was to investigate whether age-specific FSH concentration can be a predictor of the outcome of ovarian stimulation in women undergoing IVF. METHODS: A total of 676 women undergoing their first IVF cycle over a 3-year period were included in this retrospective cohort study. Patients were grouped according to age (< or ≥  38 years), and within each age range, patients were grouped into bFSH quartiles (< or ≥  9...
March 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/27549023/does-poor-ovarian-response-to-gonadotrophins-predict-early-menopause-a-retrospective-cohort-study-with-minimum-of-10-year-follow-up
#13
Natasha A K Szmidt, Siladitya Bhattacharya, Abha Maheshwari
One in 10 women reach menopause before they are 45 years of age, and 1 in 100 before 40. In most cases, poor ovarian response to gonadotrophins is a result of poor ovarian reserve. An early menopause is associated with long-term health risks. Identifying women at risk may allow appropriate measures to be instigated early. Women aged <40 years treated in the Aberdeen Fertility Centre between 1998 and 2002 were identified. Those with poor response to an age appropriate dose of gonadotrophins (obtaining ≤3 eggs or had cycle cancelled) after exclusion of hypothalamic insufficiency, or whose cycle was cancelled due to poor response were age matched with good responders (6-15 eggs)...
September 2016: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27491240/-progress-of-chinese-medicine-and-western-medicine-in-diagnosis-and-treatment-of-poor-ovarian-response-in-ivf-et-cycle
#14
Ming-xiao Ge, Li-li Tao
No abstract text is available yet for this article.
June 2016: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/27236602/a-randomized-single-blind-prospective-trial-comparing-three-different-gonadotropin-doses-with-or-without-addition-of-letrozole-during-ovulation-stimulation-in-patients-with-poor-ovarian-response
#15
Ercan Bastu, Faruk Buyru, Mehmet Ozsurmeli, Irem Demiral, Murat Dogan, John Yeh
OBJECTIVE: The aim of this randomized controlled trial (RCT) was to investigate whether IVF outcomes would differ between patients with POR who received three different gonadotropin doses with or without the addition of letrozole during ovulation stimulation. STUDY DESIGN: Only those who fulfilled two of the three Bologna criteria were included to the study. 95 patients met the inclusion criteria and agreed to participate in the study. In the first group, 31 patients were treated with 450IU gonadotropins...
August 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27203093/the-impact-of-serum-progesterone-levels-on-the-results-of-in-vitro-fertilization-treatments-a-literature-review
#16
REVIEW
Jaime Larach Del Castillo, Maroun Bousamra, Laura De La Fuente, Jose A Ruiz-Balda, Marissa Palomo
The aim of this review is to analyze the relationship between preovulatory progesterone (P) rise and in vitro fertilization (IVF) pregnancy outcomes. It also investigates the sources and effects of rises in progesterone levels, including the underlying mechanisms and potential strategies in preventing its elevation during ovarian stimulation. Progesterone is produced in the early follicular phase in the adrenal gland, which shifts toward the ovaries prior to ovulation. Several factors contribute to the etiology of P level increase including the number of multiple follicles, the overdose of gonadotropins and poor ovarian response...
2015: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/27132417/in-vitro-fertilization-outcomes-in-obese-women-under-and-above-35-years-of-age
#17
F Vural, B Vural, Y Çakiroglu
PURPOSE: To explore the impact of obesity on in vitro fertilization (IVF) outcomes and comparing the results with regards to age groups. MATERIALS AND METHODS: This retrospective cohort recruited 780 women that underwent IVF. Women with polycystic ovarian syndrome (PCOS) were excluded from the study. Women under and above 35 years were categorized into three groups as normal weight, overweight, and obese. The main outcome measures were ovarian response, oocyte maturity, and clinical pregnancy rates...
2016: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27126581/gonadotrophin-releasing-hormone-antagonists-for-assisted-reproductive-technology
#18
REVIEW
Hesham G Al-Inany, Mohamed A Youssef, Reuben Olugbenga Ayeleke, Julie Brown, Wai Sun Lam, Frank J Broekmans
BACKGROUND: Gonadotrophin-releasing hormone (GnRH) antagonists can be used to prevent a luteinizing hormone (LH) surge during controlled ovarian hyperstimulation (COH) without the hypo-oestrogenic side-effects, flare-up, or long down-regulation period associated with agonists. The antagonists directly and rapidly inhibit gonadotrophin release within several hours through competitive binding to pituitary GnRH receptors. This property allows their use at any time during the follicular phase...
April 29, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27094195/dehydroepiandrosterone-treatment-in-women-with-poor-ovarian-response-undergoing-ivf-or-icsi-a-systematic-review-and-meta-analysis
#19
REVIEW
Meixiang Zhang, Wenbin Niu, Yu Wang, Jiawei Xu, Xiao Bao, Linlin Wang, Linqing Du, Yingpu Sun
PURPOSE: We reviewed the influence of dehydroepiandrosterone (DHEA) supplementation in patients with poor ovarian response (POR) undergoing in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI). METHODS: We searched Embase, MEDLINE, PubMed, and the Cochrane Library (1980-2015) for relevant papers and used the Newcastle-Ottawa Scale scoring system to evaluate study quality. Dichotomous data were expressed as pooled relative risk (RR) estimates with fixed or random effect models...
August 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27035733/effect-of-growth-differentiation-factor%C3%A2-9%C3%A2-c447t-and-g546a-polymorphisms-on-the-outcomes-of-in%C3%A2-vitro-fertilization
#20
Monika Serdyńska-Szuster, Piotr Jędrzejczak, Katarzyna Ewa Ożegowska, Hanna Hołysz, Leszek Pawelczyk, Paweł Piotr Jagodziński
Single nucleotide polymorphisms (SNPs) in the growth differentiation factor (GDF)‑9 gene are associated with premature ovarian failure, insufficient ovarian stimulation and a poor in vitro fertilization (IVF) score in women with diminished ovarian reserve. The aim of the present study was to assess the effect of C447T (rs254286) and G546A (rs10491279) SNPs on ovary stimulation response, oocyte quality, fertilization rate and outcome of clinical pregnancy in an infertile population of Polish females (n=86) treated with IVF...
May 2016: Molecular Medicine Reports
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