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https://www.readbyqxmd.com/read/28078078/radiotherapy-in-the-management-of-gist-state-of-the-art-and-new-potential-scenarios
#1
L Gatto, M Nannini, M Saponara, V Di Scioscio, G Beltramo, G P Frezza, G Ercolani, A D Pinna, A Astolfi, M Urbini, G Brandi, G Biasco, M A Pantaleo
BACKGROUND: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. The main treatment for localized gastrointestinal stromal tumors is surgical resection. Unresectable or advanced GIST are poorly responsive to conventional cytotoxic chemotherapy but the introduction of tyrosine kinase inhibitors (TKIs) marked a revolutionary step in the treatment of these patients, radically improving prognosis and clinical benefit. Historically GIST has been considered radiation-resistant, and the role of radiotherapy in the management of patients with GIST is currently restricted to symptomatic palliation in current treatment guidelines...
2017: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/28050407/female-college-students-knowledge-attitude-and-future-intention-towards-breastfeeding-implications-for-advocacy
#2
Ramya Padmanabhan, Mahalakshmy Thulasingam, Palnivel Chinnakalai
INTRODUCTION: Breastfeeding is important for promoting child's health. Since, breastfeeding decisions are made before pregnancy and are strongly influenced by women's knowledge and attitude, it is important to identify knowledge gaps in youth girls. AIM: To assess the knowledge, attitude and future intention regarding infant feeding among female college students in Puducherry, India. MATERIALS AND METHODS: This descriptive study was done among 307 college going female students...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28048528/we-h-206-01-photoacoustic-tomography-multiscale-imaging-from-organelles-to-patients-by-ultrasonically-beating-the-optical-diffusion-limit
#3
L Wang
: Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047869/we-h-206-02-recent-advances-in-multi-modality-molecular-imaging-of-small-animals
#4
B Tsui
: Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047205/we-h-206-03-promises-and-challenges-of-benchtop-x-ray-fluorescence-ct-xfct-for-quantitative-in-vivo-imaging
#5
S Cho
: Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046461/we-h-206-00-advances-in-preclinical-imaging
#6
Patrick La Riviere
: Lihong V. Wang: Photoacoustic tomography (PAT), combining non-ionizing optical and ultrasonic waves via the photoacoustic effect, provides in vivo multiscale functional, metabolic, and molecular imaging. Broad applications include imaging of the breast, brain, skin, esophagus, colon, vascular system, and lymphatic system in humans or animals. Light offers rich contrast but does not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution pure optical imaging (e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27997931/modeling-outcomes-of-first-line-antiretroviral-therapy-and-rate-of-cd4-counts-change-among-a-cohort-of-hiv-aids-patients-in-ethiopia-a-retrospective-cohort-study
#7
Tadesse Awoke, Alemayehu Worku, Yigzaw Kebede, Adetayo Kasim, Belay Birlie, Roel Braekers, Khangelani Zuma, Ziv Shkedy
BACKGROUND: Antiretroviral therapy has shown to be effective in reducing morbidity and mortality in patients infected with HIV for the past couples of decades. However, there remains a need to better understand the characteristics of long-term treatment outcomes in resource poor settings. The main aim of this study was to determine and compare the long-term response of patients on nevirapine and efavirenz based first line antiretroviral therapy regimen in Ethiopia. METHODS: Hospital based retrospective cohort study was conducted from January 2009 to December 2013 at University hospital located in Northwest Ethiopia...
2016: PloS One
https://www.readbyqxmd.com/read/27973550/might-art-adherence-estimates-be-improved-by-combining-biomarker-and-self-report-data
#8
Rebecca Rhead, Collen Masimirembwa, Graham Cooke, Albert Takaruza, Constance Nyamukapa, Cosmas Mutsimhi, Simon Gregson
BACKGROUND: As we endeavour to examine rates of viral suppression in PLHIV, reliable data on ART adherence are needed to distinguish between the respective contributions of poor adherence and treatment failure on high viral load. Self-reported data are susceptible to response bias and although biomarker data on drug presence and concentration can provide a superior, alternative method of measurement, complications due to drug-drug interactions and genetic variations can cause some inaccuracies...
2016: PloS One
https://www.readbyqxmd.com/read/27927843/risk-of-childhood-mortality-in-family-members-of-men-with-poor-semen-quality
#9
Heidi A Hanson, Erik N Mayer, Ross E Anderson, Kenneth I Aston, Douglas T Carrell, Justin Berger, William T Lowrance, Ken R Smith, James M Hotaling
STUDY QUESTION: What is the familial childhood mortality in first-degree (FDR) and second-degree relatives (SDR) of patients undergoing semen analysis (SA)? SUMMARY ANSWER: The relationship between infertility and congenital malformations (CM) in offspring is complex, with an increased risk of death due to CM in FDR, but not SDR, of men with lower semen parameters. WHAT IS KNOWN ALREADY: Semen quality is an established predictor of men's somatic health...
January 2017: Human Reproduction
https://www.readbyqxmd.com/read/27888157/curcumin-use-in-pulmonary-diseases-state-of-the-art-and-future-perspectives
#10
REVIEW
Diana Lelli, Amirhossein Sahebkar, Thomas P Johnston, Claudio Pedone
Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma longa). It has been used for centuries in Ayurveda (Indian traditional medicine) for the treatment of several diseases. Over the last several decades, the therapeutic properties of curcumin have slowly been elucidated. It has been shown that curcumin has pleiotropic effects, regulating transcription factors (e.g., NF-kB), cytokines (e.g., IL6, TNF-alpha), adhesion molecules (e.g., ICAM-1), and enzymes (e.g., MMPs) that play a major role in inflammation and cancerogenesis...
January 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27832397/optimal-embryo-transfer-strategy-in-poor-response-may-include-freeze-all
#11
Murat Berkkanoglu, Kevin Coetzee, Hasan Bulut, Kemal Ozgur
PURPOSE: In this retrospective cohort study, we investigated the best embryo transfer strategy in ICSI cycles with ≤4 oocytes collected at oocyte retrieval. METHODS: Women who underwent antagonist co-treatment COS for ICSI treatment between January 2010 and December 2015 at a private ART clinic (N = 2263). Eight hundred seventy-nine women (group 1) had ≤4 oocytes collected at oocyte retrieval, of whom 645 (group A) had cleavage stage embryo transfer (ET), and 234 (group B) had blastocyst ET...
November 10, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27799362/animal-models-of-medullary-thyroid-cancer-state-of-the-art-and-view-to-the-future
#12
Giovanni Vitale, Germano Gaudenzi, Luisa Circelli, Marco Federico Manzoni, Andrea Bassi, Niccolò Fioritti, Antongiulio Faggiano, Annamaria Al Colao
Medullary thyroid carcinoma is a neuroendocrine tumour originating from parafollicular C cells accounting for 5-10% of thyroid cancers. Increased understanding of disease-specific molecular targets of therapy has led to the regulatory approval of two drugs (vandetanib and cabozantinib) for the treatment of medullary thyroid carcinoma. These drugs increase progression free survival, however, they are often poorly tolerated and most treatment responses are transient. Animal models are indispensable tools for investigating the pathogenesis, mechanisms for tumour invasion and metastasis, and new therapeutic approaches for cancer...
October 31, 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27746104/pigeons-and-humans-use-action-and-pose-information-to-categorize-complex-human-behaviors
#13
Muhammad A J Qadri, Robert G Cook
The biological mechanisms used to categorize and recognize behaviors are poorly understood in both human and non-human animals. Using animated digital models, we have recently shown that pigeons can categorize different locomotive animal gaits and types of complex human behaviors. In the current experiments, pigeons (go/no-go task) and humans (choice task) both learned to conditionally categorize two categories of human behaviors that did not repeat and were comprised of the coordinated motions of multiple limbs...
December 22, 2016: Vision Research
https://www.readbyqxmd.com/read/27737684/management-of-delayed-cerebral-ischemia-after-subarachnoid-hemorrhage
#14
REVIEW
Charles L Francoeur, Stephan A Mayer
For patients who survive the initial bleeding event of a ruptured brain aneurysm, delayed cerebral ischemia (DCI) is one of the most important causes of mortality and poor neurological outcome. New insights in the last decade have led to an important paradigm shift in the understanding of DCI pathogenesis. Large-vessel cerebral vasospasm has been challenged as the sole causal mechanism; new hypotheses now focus on the early brain injury, microcirculatory dysfunction, impaired autoregulation, and spreading depolarization...
October 14, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27723012/poorly-designed-research-does-not-help-clarify-the-role-of-hyperbaric-oxygen-in-the-treatment-of-chronic-diabetic-foot-ulcers
#15
EDITORIAL
Mesut Mutluoglu, Gunalp Uzun, Michael Bennett, Peter Germonpré, David Smart, Daniel Mathieu
Diabetic foot ulcers (DFUs) are one of the most common indications for hyperbaric oxygen treatment (HBOT). The role of HBOT in DFUs is often debated. Recent evidence based guidelines, while recommending its use, urge further studies to identify the patient subgroups most likely to benefit from HBOT. A recent study in Diabetes Care aimed to assess the efficacy of HBOT in reducing the need for major amputation and improving wound healing in patients with chronic DFUs. In this study, patients with Wagner grade 2-4 diabetic foot lesions were randomly assigned to have HBOT (30 sessions/90 min/244 kPa) or sham treatment (30 sessions/90 min/air/125 kPa)...
September 2016: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/27701900/impaired-upregulation-of-the-costimulatory-molecules-cd27-and-cd28-on-cd4-sup-sup-t-cells-from-hiv-patients-receiving-art-is-associated-with-poor-proliferative-responses
#16
Sara Tanaskovic, Patricia Price, Martyn A French, Sonia Fernandez
HIV patients beginning antiretroviral therapy (ART) with advanced immunodeficiency often retain low CD4<sup>+</sup> T-cell counts despite virological control. We examined proliferative responses and upregulation of costimulatory molecules following anti-CD3 stimulation, in HIV patients with persistent CD4<sup>+</sup> T-cell deficiency on ART. Aviraemic HIV patients with nadir CD4<sup>+</sup> T-cell counts <100 cells/μl who had received ART for a median time of 7 (range 1-11) years were categorized into those achieving low (<350 cells/μL; n=13) or normal (>500 cells/μL; n=20) CD4<sup>+</sup> T-cell counts...
October 5, 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27689035/the-meaning-of-anti-m%C3%A3-llerian-hormone-levels-in-patients-at-a-high-risk-of-poor-ovarian-response
#17
REVIEW
Hyun Jong Park, Geun Ho Lee, Du Sik Gong, Tae Ki Yoon, Woo Sik Lee
Measurements of ovarian reserve play an important role in predicting the clinical results of assisted reproductive technology (ART). The ideal markers of ovarian reserve for clinical applications should have high specificity in order to determine genuine poor responders. Basal follicle-stimulating hormone levels, antral follicle count, and serum anti-Müllerian hormone (AMH) levels have been suggested as ovarian reserve tests that may fulfill this requirement, with serum AMH levels being the most promising parameter...
September 2016: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/27613775/hiv-suppression-restores-the-lung-mucosal-cd4-t-cell-viral-immune-response-and-resolves-cd8-t-cell-alveolitis-in-patients-at-risk-for-hiv-associated-chronic-obstructive-pulmonary-disease
#18
Iulia Popescu, M Bradley Drummond, Lucio Gama, Allison Lambert, Aki Hoji, Tiffany Coon, Christian A Merlo, Robert A Wise, Jeanne Keruly, Janice E Clements, Gregory D Kirk, John F McDyer
BACKGROUND:  Lung CD4(+) T-cell depletion and dysfunction, CD8(+) T-cell alveolitis, smoking, and poor control of human immunodeficiency virus (HIV) are features of HIV-associated chronic obstructive pulmonary disease (COPD), but these changes have not been evaluated in smokers at risk for COPD. We evaluated the impact of viral suppression following initiation of antiretroviral therapy (ART) on HIV-specific immunity and the balance of the CD4(+) T-cell to CD8(+) T-cell ratio in the lung...
November 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27512678/patient-derived-mesenchymal-stem-cells-as-delivery-vehicles-for-oncolytic-virotherapy-novel-state-of-the-art-technology
#19
REVIEW
Manuel Ramírez, Javier García-Castro, Gustavo J Melen, África González-Murillo, Lidia Franco-Luzón
Oncolytic virotherapy is gaining interest in the clinic as a new weapon against cancer. In vivo administration of oncolytic viruses showed important limitations that decrease their effectiveness very significantly: the antiviral immune response causes the elimination of the therapeutic effect, and the poor natural ability of oncolytic viruses to infect micrometastatic lesions significantly minimizes the effective dose of virus. This review will focus on updating the technical and scientific foundations of one of the strategies developed to overcome these limitations, ie, using cells as vehicles for oncolytic viruses...
2015: Oncolytic Virotherapy
https://www.readbyqxmd.com/read/27482082/contrasting-climate-change-impact-on-river-flows-from-high-altitude-catchments-in-the-himalayan-and-andes-mountains
#20
Silvan Ragettli, Walter W Immerzeel, Francesca Pellicciotti
Mountain ranges are the world's natural water towers and provide water resources for millions of people. However, their hydrological balance and possible future changes in river flow remain poorly understood because of high meteorological variability, physical inaccessibility, and the complex interplay between climate, cryosphere, and hydrological processes. Here, we use a state-of-the art glacio-hydrological model informed by data from high-altitude observations and the latest climate change scenarios to quantify the climate change impact on water resources of two contrasting catchments vulnerable to changes in the cryosphere...
August 16, 2016: Proceedings of the National Academy of Sciences of the United States of America
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