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https://www.readbyqxmd.com/read/29447718/no-240-cytomegalovirus-infection-in-pregnancy
#1
Yoav Yinon, Dan Farine, Mark H Yudin
OBJECTIVES: To review the principles of prenatal diagnosis of congenital cytomegalovirus (CMV) infection and to describe the outcomes of the affected pregnancies. OUTCOMES: Effective management of fetal infection following primary and secondary maternal CMV infection during pregnancy. Neonatal signs include intrauterine growth restriction (IUGR), microcephaly, hepatosplenomegaly, petechiae, jaundice, chorioretinitis, thrombocytopenia and anemia, and long-term sequelae consist of sensorineural hearing loss, mental retardation, delay of psychomotor development, and visual impairment...
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29417431/epoetin-biosimilars-in-the-treatment-of-chemotherapy-induced-anemia-10%C3%A2-years-experience-gained
#2
REVIEW
Matti Aapro, Andriy Krendyukov, Martin Schiestl, Pere Gascón
High-quality, safe, and effective biosimilars have the potential to increase access to biological therapies worldwide and to reduce cancer care costs. The European Medicines Agency (EMA) was the first regulatory authority to establish legislative procedures for the approval of biosimilars when they published their guidelines on similar biological medicinal products in 2005. Biosimilar epoetins were first approved in 2007, and a wealth of data has been collected over the last decade. Two biosimilar epoetins (under five commercial names) have been approved by the EMA so far...
February 7, 2018: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/29402286/a-review-of-the-experimental-evidence-on-the-toxicokinetics-of-carbon-monoxide-the-potential-role-of-pathophysiology-among-susceptible-groups
#3
REVIEW
Prabjit Barn, Luisa Giles, Marie-Eve Héroux, Tom Kosatsky
BACKGROUND: Acute high level carbon monoxide (CO) exposure can cause immediate cardio-respiratory arrest in anyone, but the effects of lower level exposures in susceptible persons are less well known. The percentage of CO-bound hemoglobin in blood (carboxyhemoglobin; COHb) is a marker of exposure and potential health outcomes. Indoor air quality guidelines developed by the World Health Organization and Health Canada, among others, are set so that CO exposure does not lead to COHb levels above 2...
February 5, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29393257/clinical-utility-of-capsule-endoscopy-and-double-balloon-enteroscopy-in-the-management-of-obscure-gastrointestinal-bleeding
#4
Koji Otani, Toshio Watanabe, Sunao Shimada, Shuhei Hosomi, Yasuaki Nagami, Fumio Tanaka, Noriko Kamata, Koichi Taira, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Yasuhiro Fujiwara
BACKGROUND: Obscure gastrointestinal bleeding (OGIB) is a common but embarrassing problem for gastroenterologists. Most bleeding lesions associated with OGIB are present in the small intestine and sometimes cannot be identified due to the difficulty associated with physical accessibility. Capsule endoscopy (CE) and double-balloon enteroscopy (DBE) have enabled in the process of diagnosing and have evolved to become approaches to treating OGIB. SUMMARY: CE is a minimally invasive procedure and has a high diagnostic yield in patients with OGIB...
February 1, 2018: Digestion
https://www.readbyqxmd.com/read/29386046/factors-associated-with-timing-of-umbilical-cord-clamping-in-tertiary-hospital-of-nepal
#5
Viktoria Nelin, Ashish Kc, Ola Andersson, Nisha Rana, Mats Målqvist
OBJECTIVE: Delayed umbilical cord clamping (DCC) (≥ 60 s) is recognized to improve iron status and neurodevelopment compared to early umbilical cord clamping. The aim of this study is to identify current umbilical cord clamping practice and factors determining the timing of clamping in a low-resource setting where prevalence of anemia in infants is high. RESULTS: A cross-sectional study design including 128 observations of clinical practice in a tertiary-level maternity hospital in Kathmandu, Nepal...
January 31, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29385057/dietary-balance-index-07-and-the-risk-of-anemia-in-middle-aged-and-elderly-people-in-southwest-china-a-cross-sectional-study
#6
Qiang Zhang, Guanghe Qin, Zhitao Liu, Zi Li, Juanjuan Li, Deepthi S Varma, Qingqing Wan, Jiang Zhao, Xiangdong Min, Xingmeng Han, Min Liu
A balanced diet is essential to achieve and maintain good health. In this study, we assessed diet quality of middle aged and elderly people based on Chinese Diet Balance Index-07 (DBI-07) and explored the associations between DBI-07 and anemia. Data analyzed for this study was from the 2010-2012 National Nutrition and Health Survey in Yunnan province, southwest China (n = 738, aged 50-77 years). Dietary recalls over there consecutive days were done in a face-to-face interview. The scores of DBI-07 for each component and three DBI-07 indicators ((Lower Bound Score (LBS), Higher Bound Score (HBS), Diet Quality Distance (DQD)) were calculated according to compliance with the Dietary Guidelines for Chinese residents...
January 31, 2018: Nutrients
https://www.readbyqxmd.com/read/29381721/transfusion-practice-in-anemic-non-bleeding-patients-cross-sectional-survey-of-physicians-working-in-general-internal-medicine-teaching-hospitals-in-switzerland
#7
Michelle von Babo, Corinne Chmiel, Simon Andreas Müggler, Julia Rakusa, Caroline Schuppli, Philipp Meier, Manuel Fischler, Martin Urner
BACKGROUND: Transfusion practice might significantly influence patient morbidity and mortality. Between European countries, transfusion practice of red blood cells (RBC) greatly differs. Only sparse data are available on transfusion practice of general internal medicine physicians in Switzerland. METHODS: In this cross-sectional survey, physicians working in general medicine teaching hospitals in Switzerland were investigated regarding their self-reported transfusion practice in anemic patients without acute bleeding...
2018: PloS One
https://www.readbyqxmd.com/read/29378625/outcome-and-prognostic-factors-in-cervical-cancer-patients-treated-with-surgery-and-concurrent-chemoradiotherapy-a-retrospective-study
#8
Yan-Mei Liu, Ling-Qin Ni, Sai-Sai Wang, Qian-Ling Lv, Wei-Jun Chen, Shen-Peng Ying
BACKGROUND: The objective of this study is to analyze the treatment outcome and secondary reactions in 98 patients with stage I-III cervical carcinoma who underwent postoperative radiotherapy. METHODS: From 2006 to 2014, 98 patients with stage I-III cervical carcinoma were treated with postoperative radiotherapy. The major histological type, found in 92.86% of the patients (91 cases), was squamous cell carcinoma. Patients were staged according to the 2002 TNM guidelines...
January 29, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29371779/hyperferritinemia-in-hemophagocytic-lymphohistiocytosis-a-single-institution-experience-in-pediatric-patients
#9
Surupa Basu, Biplab Maji, Santanu Barman, Apurba Ghosh
Hemophagocytic lymphohistiocytosis (HLH) is an inflammatory condition that may run a rapid fatal course and calls for prompt diagnosis. Early intervention with steroids and other immunosuppressive drugs can contain the disease process and favours positive outcome. Ferritin ≥500 ng/ml is a HLH diagnostic criterion. We evaluated the diagnostic potential of admission ferritin, in children with HLH. Pediatric patients of a referral teaching hospital from Feb 2010-Oct 2013 having been investigated for ferritin on admission were included...
January 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29366423/therapeutic-approach-to-patients-with-heart-failure-with-reduced-ejection-fraction-and-end-stage-renal-disease
#10
Chakradhari Inampudi, Paulino Alvarez, Rabea Asleh, Alexandros Briasoulis
Several risk factors including Ischemic heart disease, uncontrolled hypertension, high output heart failure (HF) from shunting through vascular hemodialysis access, and anemia, contribute to development of HF in patients with end-stage renal disease (ESRD). Guideline-directed medical and device therapy for Heart Failure with Reduced Ejection Fraction (HFrEF) has not been extensively studied and may have limited safety and efficacy in patients with ESRD. Maintenance of interdialytic and intradialytic euvolemia is a key component of HF management in these patients but often difficult to achieve...
January 23, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29360515/choosing-wisely-bmt-american-society-for-blood-and-marrow-transplantation-and-canadian-blood-and-marrow-transplant-group-s-list-of-five-tests-and-treatments-to-question-in-blood-and-marrow-transplantation
#11
REVIEW
Sita Bhella, Navneet S Majhail, Jeffrey Betcher, Luciano J Costa, Andrew Daly, Christopher E Dandoy, Zachariah DeFilipp, Vi Doan, Alison Gulbis, Lisa Hicks, Mark Juckett, Nandita Khera, Amrita Krishnan, George Selby, Nirav N Shah, Melisa Stricherz, Auro Viswabandya, Christopher Bredeson, Matthew D Seftel
Choosing Wisely encourages dialogue about reducing unnecessary procedures, tests, or treatments in healthcare. The American Society for Blood and Marrow Transplantation (ASBMT) and Canadian Blood and Marrow Transplant Group (CBMTG) established a Choosing Wisely BMT Task Force whose objective was to create a list of top five practices in blood and marrow transplantation to be questioned. The Task Force consisted of representatives from ASBMT's Quality Outcomes, Education, and Practice Guidelines Committees, ASBMT's Pharmacy Special Interest Group, CBMTG Program Directors, and Center for International Blood and Marrow Transplant Research (CIBMTR)...
January 19, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29357912/eregqual-an-electronic-health-registry-with-interactive-checklists-and-clinical-decision-support-for-improving-quality-of-antenatal-care-study-protocol-for-a-cluster-randomized-trial
#12
Mahima Venkateswaran, Kjersti Mørkrid, Buthaina Ghanem, Eatimad Abbas, Itimad Abuward, Mohammad Baniode, Ole Frithjof Norheim, J Frederik Frøen
BACKGROUND: Health worker compliance with established best-practice clinical and public health guidelines may be enhanced by customized checklists of care and clinical decision support driven by point-of-care data entry into an electronic health registry. The public health system of Palestine is currently implementing a national electronic registry (eRegistry) for maternal and child health. This trial is embedded in the national implementation and aims to assess the effectiveness of the eRegistry's interactive checklists and clinical decision support, compared with the existing paper based records, on improving the quality of care for pregnant women...
January 22, 2018: Trials
https://www.readbyqxmd.com/read/29357391/iron-deficiency-across-chronic-kidney-disease-stages-is-there-a-reverse-gender-pattern
#13
Mabel Aoun, Rita Karam, Ghassan Sleilaty, Leony Antoun, Walid Ammar
In non-dialysis chronic kidney disease patients, looking for iron deficiency is highly variable in practice and there is a great variability regarding the cutoffs used to treat iron deficiency. The aim of this study is to investigate the degree of iron deficiency in non-dialysis chronic kidney disease patients on erythropoiesis-stimulating agents. We included all non-dialysis chronic kidney disease patients that applied to the Lebanese Ministry of Public Health for erythropoiesis-stimulating agents' coverage during a 5-month period...
2018: PloS One
https://www.readbyqxmd.com/read/29353050/helicobacter-pylori-infection-an-update-for-the-internist-in-the-age-of-increasing-global-antibiotic-resistance
#14
REVIEW
Osama Siddique, Anais Ovalle, Ayesha S Siddique, Steven F Moss
Helicobacter pylori (H. pylori) infects approximately half the world's population and is especially prevalent in the developing world. H. pylori is as an important cause of global ill health due to its known etiological role in peptic ulcer disease, dyspepsia, gastric cancer, lymphoma and, more recently recognised in iron deficiency anemia and idiopathic thrombocytopenic purpura. Increased antibiotic usage worldwide has led to antibiotic resistance among many bacteria, including H. pylori, resulting in falling success rates of first-line anti-H...
January 15, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29350428/meta-analysis-of-fish-early-life-stage-tests-association-of-toxic-ratios-and-acute-to-chronic-ratios-with-modes-of-action
#15
REVIEW
Stefan Scholz, Rene Schreiber, James Armitage, Philipp Mayer, Beate I Escher, Annegret Lidzba, Marc Léonard, Rolf Altenburger
Fish early life stage (FELS) tests (OECD test guideline 210) are widely conducted to estimate chronic fish toxicity. In these tests, fish are exposed from the embryonic to the juvenile life stage. In order to analyse whether certain modes of action are related to high toxic ratios (TR, i.e., ratios between experimental effect and baseline toxicity) and/or acute-to-chronic ratios (ACR) in the FELS test effect concentrations for 183 compounds were extracted from the US EPA ecotoxicity database. Analysis of effect concentration of narcotic compounds indicated that baseline toxicity could be observed in the FELS test at similar concentrations as in acute fish toxicity test...
January 19, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29336240/treatment-of-anemia-in-patients-with-solid-tumors-receiving-chemotherapy-in-palliative-setting-usual-practice-versus-guidelines
#16
Robin de Putter, Karen Geboes, Marc De Man, Simon Van Belle
Background Anemia is frequent in patients with cancer and is often multifactorial. Treatment depends on etiology and can consist of transfusions, intravenous iron (IV Fe), and/or erythropoiesis-stimulating agents (ESA). Several studies have shown that cancer-related anemia is undertreated. The aim of this study is to compare usual practice in a university hospital with the international guidelines. Methods Using the hospital and pharmacy informatics all adults (≥18 years), who received a treatment for anemia (transfusion, IV Fe, ESA) from February to August 2016 during palliative chemotherapy, were identified...
January 16, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29335019/patient-blood-management-programs-how-to-spread-the-word
#17
Shoshana Revel-Vilk, Mira Naamad
Red blood cell (RBC) transfusions save lives and improve health; however, unnecessary transfusion practice exposes patients to immediate and long-term negative consequences. Indirect consequences of unnecessary transfusions are the reduced availability of RBC units for patients who are in need. Accumulating evidence shows that restricting RBC transfusions improves outcomes and current guidelines suggest limiting RBC transfusion to the minimum number of units required to relieve symptoms of anemia or to return the patient to a safe hemoglobin range (7-8 g/dl in stable, non-cardiac inpatients)...
January 15, 2018: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/29333401/management-of-immune-thrombocytopenia-korean-experts-recommendation-in-2017
#18
REVIEW
Jun Ho Jang, Ji Yoon Kim, Yeung-Chul Mun, Soo-Mee Bang, Yeon Jung Lim, Dong-Yeop Shin, Young Bae Choi, Ho-Young Yhim, Jong Wook Lee, Hoon Kook
Management options for patients with immune thrombocytopenia (ITP) have evolved substantially over the past decades. The American Society of Hematology published a treatment guideline for clinicians referring to the management of ITP in 2011. This evidence-based practice guideline for ITP enables the appropriate treatment of a larger proportion of patients and the maintenance of normal platelet counts. Korean authority operates a unified mandatory national health insurance system. Even though we have a uniform standard guideline enforced by insurance reimbursement, there are several unsolved issues in real practice in ITP treatment...
December 2017: Blood Research
https://www.readbyqxmd.com/read/29280423/anemia-was-an-uncommon-complication-of-severe-malaria-in-a-high-transmission-rural-area-of-western-uganda
#19
Ross Boyce, Raquel Reyes, Corinna Keeler, Michael Matte, Moses Ntaro, Edgar Mulogo, Mark J Siedner
The clinical epidemiology of severe malaria among patients presenting to peripheral health centers has not been well described. We conducted a prospective, observational cohort study to describe the epidemiology and clinical manifestations of severe malaria in a highland area of declining transmission intensity in Western Uganda. Individuals presenting with a history of fever were screened with a malaria rapid diagnostic test (RDT). We prepared blood smears and conducted clinical and laboratory testing for those with a positive RDT...
December 26, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29260649/are-infants-less-than-6-months-of-age-a-neglected-group-for-anemia-prevention-in-low-income-countries
#20
Cinta Moraleda, Regina N Rabinovich, Pedro L Alonso, Clara Menéndez
Anemia is a major public health problem that affects mainly children, predominantly in low-income countries and most often due to iron deficiency (ID). Administration of iron supplements to prevent and treat ID anemia in malaria endemic areas has been controversial for decades; however, recent World Health Organization guidelines recommend universal iron supplementation for children in highly prevalent anemia settings, including those where malaria is endemic. However, infants younger than 6 months of age have been exempted from this recommendation because ID is not considered prevalent at this age and because of assumptions-without evidence-that they are protected from ID through breast milk...
December 18, 2017: American Journal of Tropical Medicine and Hygiene
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