keyword
https://read.qxmd.com/read/38534919/review-on-the-role-of-brca-mutations-in-genomic-screening-and-risk-stratification-of-prostate-cancer
#21
REVIEW
Nikolaos Kalampokis, Christos Zabaftis, Theodoros Spinos, Markos Karavitakis, Ioannis Leotsakos, Ioannis Katafigiotis, Henk van der Poel, Nikolaos Grivas, Dionysios Mitropoulos
(1) Background: Somatic and germline alterations can be commonly found in prostate cancer (PCa) patients. The aim of our present study was to perform a comprehensive review of the current literature in order to examine the impact of BRCA mutations in the context of PCa as well as their significance as genetic biomarkers. (2) Methods: A narrative review of all the available literature was performed. Only "landmark" publications were included. (3) Results: Overall, the number of PCa patients who harbor a BRCA2 mutation range between 1...
February 22, 2024: Current Oncology
https://read.qxmd.com/read/38534805/knowledge-attitudes-and-practices-of-hand-hygiene-mask-use-and-social-distancing-among-public-hospital-and-polyclinic-nurses-in-barbados-during-the-coronavirus-2019-pandemic
#22
JOURNAL ARTICLE
Uma Gaur, Wendy Sealy, Ambadasu Bharatha, Natasha P Sobers, Kandamaran Krishnamurthy, Michael H Campbell, Cara Cumberbatch, Maia Drakes, Marielle Gibbs, Charisse Alexander, Heather Harewood, O Peter Adams, Subir Gupta, Ali Davod Parsa, Russell Kabir, Md Anwarul Azim Majumder
BACKGROUND: Nurses are essential members of the healthcare workforce and were among the first-line carers for patients in community and hospital settings during the COVID-19 pandemic. As a result, they were at a heightened risk of infection, resulting in several reported deaths among nursing staff. Several preventive measures were adopted to contain the spread of the COVID-19 virus. This study aims to explore the knowledge, attitudes, and practices (KAP) of nurses regarding hand hygiene, mask wearing, and social distancing measures in healthcare settings in Barbados during the COVID-19 pandemic...
March 6, 2024: Epidemiologia (Basel)
https://read.qxmd.com/read/38534761/genetic-signatures-for-distinguishing-chemo-sensitive-from-chemo-resistant-responders-in-prostate-cancer-patients
#23
JOURNAL ARTICLE
Lemohang Gumenku, Mamello Sekhoacha, Beynon Abrahams, Samson Mashele, Aubrey Shoko, Ochuko L Erukainure
Prostate cancer remains a significant public health concern in sub-Saharan Africa, particularly impacting South Africa with high mortality rates. Despite many years of extensive research and significant financial expenditure, there has yet to be a definitive solution to prostate cancer. It is not just individuals who vary in their response to treatment, but even different nodules within the same tumor exhibit unique transcriptome patterns. These distinctions extend beyond mere differences in gene expression levels to encompass the control and networking of individual genes...
March 11, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534138/the-functional-small-rna-interactome-reveals-targets-for-the-vancomycin-responsive-srna-rsaoi-in-vancomycin-tolerant-staphylococcus-aureus
#24
JOURNAL ARTICLE
Winton Wu, Chi Nam Ignatius Pang, Daniel G Mediati, Jai Justin Tree
UNLABELLED: Small RNAs have been found to control a broad range of bacterial phenotypes including tolerance to antibiotics. Vancomycin tolerance in multidrug resistance Staphylococcus aureus is correlated with dysregulation of small RNAs although their contribution to antibiotic tolerance is poorly understood. RNA-RNA interactome profiling techniques are expanding our understanding of sRNA-mRNA interactions in bacteria; however, determining the function of these interactions for hundreds of sRNA-mRNA pairs is a major challenge...
March 27, 2024: MSystems
https://read.qxmd.com/read/38533711/cancer-pain-patients-do-not-successfully-handle-opioids
#25
JOURNAL ARTICLE
Liel Kosev, Ofir Morag, Michelle Levitan, Itay Goor-Aryeh
OBJECTIVE: To evaluate patterns of opioid handling as well as their associated -variables. DESIGN: A transversal study. SETTING: Institutional care. PARTICIPANTS: One hundred cancer pain patients aged 18 and above at diagnosis. INTERVENTIONS: Open and dichotomous questions related to opioid handling and a depression-anxiety scale. MAIN OUTCOME MEASURE(S): The percentage of patients who properly handled opioids...
2024: Journal of Opioid Management
https://read.qxmd.com/read/38533625/aspirin-loaded-anti-inflammatory-zno-sio-2-aerogel-scaffolds-for-bone-regeneration
#26
JOURNAL ARTICLE
Yue Zhao, Caiqi Cheng, Xinyi Wang, Zhengchao Yuan, Binbin Sun, Mohamed El-Newehy, Meera Moydeen Abdulhameed, Bing Fang, Xiumei Mo
The increasing aging of the population has elevated bone defects to a significant threat to human life and health. Aerogel, a biomimetic material similar to an extracellular matrix (ECM), is considered an effective material for the treatment of bone defects. However, most aerogel scaffolds suffer from immune rejection and poor anti-inflammatory properties and are not well suited for human bone growth. In this study, we used electrospinning to prepare flexible ZnO-SiO2 nanofibers with different zinc concentrations and further assembled them into three-dimensional composite aerogel scaffolds...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38533491/identification-of-novel-blood-based-extracellular-vesicles-biomarker-candidates-with-potential-specificity-for-traumatic-brain-injury-in-polytrauma-patients
#27
JOURNAL ARTICLE
Cora R Schindler, Jason A Hörauf, Birte Weber, Inna Schaible, Ingo Marzi, Dirk Henrich, Liudmila Leppik
OBJECTIVE: The goal of this study was to identify changes in extracellular vesicles (EV) surface proteins specific to traumatic brain injury (TBI), which could be used as a diagnostic and prognostic tool in polytrauma patients. SUMMARY BACKGROUND DATA: Known serum TBI-specific biomarkers (S100B, NSE, and GFAP), which can predict the severity and outcome of isolated TBI, lose their predictive value in the presence of additional extracranial injuries. Extracellular vesicles (EVs) are released from cells in response to various stimuli and carry specific cargo/surface molecules that could be used for tracking injury-responding cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533321/decoding-the-rejection-code-understanding-why-articles-get-axed
#28
EDITORIAL
Vishal V Bhende, Tanishq S Sharma, Mathangi Krishnakumar, Anikode Subramanian Ramaswamy, Kanchan Bilgi, Saptak P Mankad
In the competitive arena of medical publishing, manuscript rejection remains a significant barrier to disseminating research findings. This editorial delves into the multifaceted nature of manuscript rejection, elucidating common reasons and proposing actionable strategies for authors to enhance their chances of acceptance. Key rejection factors include a mismatch with journal scope, lack of novelty, methodological flaws, inconclusive results, ethical issues, poor presentation, data inaccessibility, author misconduct, and plagiarism...
March 2024: Curēus
https://read.qxmd.com/read/38533207/integrative-analysis-identifies-cancer-cell-intrinsic-rarres1-as-a-predictor-of-prognosis-and-immune-response-in-triple-negative-breast-cancer
#29
JOURNAL ARTICLE
Zhengheng Yu, Hongjin Liu, Jingming Ye, Yinhua Liu, Ling Xin, Qian Liu, Yuanjia Cheng, Lu Yin, Ling Xu
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis and limited treatment options. Although immune checkpoint inhibitors (ICIs) have been proven to improve outcomes in TNBC patients, the potential mechanisms and markers that determine the therapeutic response to ICIs remains uncertain. Revealing the relationship and interaction between cancer cells and tumor microenvironment (TME) could be helpful in predicting treatment efficacy and developing novel therapeutic agents. By analyzing single-cell RNA sequencing dataset, we comprehensively profiled cell types and subpopulations as well as identified their signatures in the TME of TNBC...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38533173/pre-operative-planning-of-high-tibial-osteotomy-with-chatgpt-are-we-there-yet
#30
JOURNAL ARTICLE
Dhivakaran Gengatharan, Sandip Singh Saggi, Hamid Rahmatullah Bin Abd Razak
INTRODUCTION: ChatGPT (Chat Generative Pre-trained Transformer), developed by OpenAI (San Francisco, CA, USA), has gained attention in the medical field. It has the potential to enhance and simplify tasks, such as preoperative planning in orthopedic surgery. We aimed to test ChatGPT's accuracy in measuring the angle of correction for high tibial osteotomy for cases planned and performed at a tertiary teaching hospital in Singapore. MATERIALS AND METHODS: Peri-operative angular parameters from 114 consecutive patients who underwent medial opening wedge high tibial osteotomy (MOWHTO) were used to query ChatGPT 3...
February 2024: Curēus
https://read.qxmd.com/read/38533063/predictive-value-of-procollagen-c-protease-enhancer-protein-on-the-prognosis-of-glioma-patients
#31
JOURNAL ARTICLE
Luli Yu, Xinyao Hu, Hua Zhu
Procollagen c-protease enhancer protein (PCOLCE) performs an essential action in improving the recreation of procollagen c-protease and promoting the reconstruction of extracellular matrix. High PCOLCE expression was associated with a negative prognosis of stomach cancer, ovarian cancer, and osteosarcoma. The goal of this work is to investigate the function of PCOLCE in glioma. Multiple bioinformatics techniques have been employed to investigate the roles of PCOLCE in glioma, consisting of the correlation between PCOLCE and prognosis, immune checkpoints, immune cell infiltrates, and tumor microenvironment (TME)...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532968/current-knowledge-of-human-mpox-viral-infection-among-healthcare-workers-in-cameroon-calls-for-capacity-strengthening-for-pandemic-preparedness
#32
JOURNAL ARTICLE
Alex Durand Nka, Yagai Bouba, Joseph Fokam, Aude Christelle Ka'e, Jeremiah Efakika Gabisa, Nadia Mandeng, Delors Jacques Toumansie Mfonkou, Chenwi Collins Ambe, Marie-Laure Mballa Mpouel, Tatiana Djikeussi, Boris Kevin Tchounga, Derrick Tambe Ayuk Ngwese, Debimeh Njume, Sonia Emmanuelle Mbala Nomo, Ezechiel Ngoufack Jagni Semengue, Armand Tiotsia Tsapi, Bernadette Bomgning Fokou, Ingrid Koster Simo Kamdem, Michel Carlos Tommo Tchouaket, Désiré Takou, Willy Pabo, Samuel Martin Sosso, Erick Tandi, Linda Esso, Georges Alain Etoundi Mballa, Anne-Cecile Zoung-Kanyi Bissek, Halle-Ekane Gregory Edie, Nicaise Ndembi, Vittorio Colizzi, Carlo-Federico Perno, Alexis Ndjolo
INTRODUCTION: An increased incidence of human Monkeypox (Mpox) cases was recently observed worldwide, including in Cameroon. To ensure efficient preparedness and interventions in the health system, we sought to assess the knowledge of Mpox's transmission, prevention, and response among healthcare workers (HCWs) in Cameroon. METHODS: A cross-sectional online survey was conducted among HCWs in Cameroon using 21-item questions adapted from the United States Centers for Disease Control and Prevention (US-CDC) standard questionnaire on Mpox...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38532677/-improving-the-standby-process-completion-rate-among-nurses-for-high-risk-neonates
#33
JOURNAL ARTICLE
Mo-Fen Wu, Li-Ying Chung
BACKGROUND & PROBLEMS: Readiness process effectiveness significantly impacts the safety of high-risk neonates and requires an immediately responsive and well-trained healthcare team. Analysis of our unit found the high-risk neonatal standby process completion rate among nursing staff to be very low. Reasons for this poor level of performance included absence of standardized procedures for high-risk neonatal standby, lack of an auditing system, inadequate education and training, multiple medical supplies in the standby kits, absence of a checklist for the kits, and failure to regularly inventory the contents of these kits...
April 2023: Hu Li za Zhi the Journal of Nursing
https://read.qxmd.com/read/38532645/defense-and-senescence-interplay-in-legume-nodules
#34
REVIEW
Fathi Berrabah, Farouk Benaceur, Chaoyan Yin, Dawei Xin, Kévin Magne, Marie Garmier, Véronique Gruber, Pascal Ratet
Immunity and senescence play a crucial role in the functioning of the legume symbiotic nodules. The miss-regulation of one of these processes compromises the symbiosis leading to death of the endosymbiont and the arrest of the nodule functioning. The relationship between immunity and senescence is highly studied in plant organs where a synergistic response can be observed. However, the interplay between immunity and senescence in the symbiotic organ is poorly discussed in the literature and these phenomena are often mixed up...
March 25, 2024: Plant communications
https://read.qxmd.com/read/38532632/m6a-mediated-molecular-patterns-and-tumor-microenvironment-infiltration-characterization-in-nasopharyngeal-carcinoma
#35
JOURNAL ARTICLE
Yong Wang, Lisha Peng, Feng Wang
N6-methyladenosine (m6A) is the most predominant RNA epigenetic regulation in eukaryotic cells. Numerous evidence revealed that m6A modification exerts a crucial role in the regulation of tumor microenvironment (TME) cell infiltration in several tumors. Nevertheless, the potential role and mechanism of m6A modification in nasopharyngeal carcinoma (NPC) remains unknown. mRNA expression data and clinical information from GSE102349, and GSE53819 datasets obtained from Gene Expression Omnibus (GEO) was used for differential gene expression and subsequent analysis...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38532575/long-term-outcome-of-peripheral-t-cell-lymphomas-ten-year-follow-up-of-the-international-prospective-t-cell-project
#36
JOURNAL ARTICLE
M Civallero, J G Schroers-Martin, S Horwitz, M Manni, Y Stepanishyna, M E Cabrera, J Vose, M Spina, F Hitz, A Nagler, S Montoto, C Chiattone, T Skrypets, M A Perez Saenz, G Priolo, S Luminari, A Lymboussaki, A Pavlovsky, D Marino, M Liberati, J Trotman, D Mannina, M Federico, R Advani
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of haematological cancers with generally poor clinical outcomes. However, a subset of patients experience durable disease control, and little is known regarding long-term outcomes. The International T-cell Lymphoma Project (ITCLP) is the largest prospectively collected cohort of patients with PTCLs, providing insight into clinical outcomes at academic medical centres globally. We performed a long-term outcome analysis on patients from the ITCLP with available 10-year follow-up data (n = 735)...
March 26, 2024: British Journal of Haematology
https://read.qxmd.com/read/38532447/peptidoglycan-in-osteoarthritis-synovial-tissue-is-associated-with-joint-inflammation
#37
JOURNAL ARTICLE
Meaghan N Holub, Amanda Wahhab, Joseph R Rouse, Rebecca Danner, Lauren G Hackner, Christine B Duris, Mecaila E McClune, Jules M Dressler, Klemen Strle, Brandon L Jutras, Adam I Edelstein, Robert B Lochhead
OBJECTIVES: Peptidoglycan (PG) is an arthritogenic bacterial cell wall component whose role in human osteoarthritis is poorly understood. The purpose of this study was to determine if PG is present in synovial tissue of osteoarthritis patients at the time of primary total knee arthroplasty (TKA), and if its presence is associated with inflammation and patient reported outcomes. METHODS: Intraoperative synovial tissue and synovial fluid samples were obtained from 56 patients undergoing primary TKA, none of whom had history of infection...
March 27, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38532360/changes-in-social-mixing-and-attitudes-and-practices-to-precautionary-measures-in-a-maturing-covid-19-pandemic-in-six-communities-in-sudan-a-qualitative-study
#38
JOURNAL ARTICLE
Salma A E Ahmed, Rahaf AbuKoura, Abd Elhameed Ahmed, Omama Abdalla, Omnia Kamal Hassan, Ahmed Tom, Ahmed Eldirdiri, Drieg Ismaeil, Israa Zainalabdeen, Nazik Nurelhuda, Aljaile Ahmed, Afrah Abdan, Maysoon Dahab, Nada Abdelmagid
INTRODUCTION: With low COVID-19 vaccination coverage, non-pharmaceutical interventions were critical to mitigating the COVID-19 pandemic in Sudan. We explored changes in social contact patterns, risk perception, attitudes, and practices toward protective measures during an evolving COVID-19 outbreak in six illustrative communities in Sudan. METHODS: This qualitative study took place in six communities in five Sudanese states using focus group discussions with community members and non-participant structured observations in public spaces between March 2021 and April 2021...
March 26, 2024: BMC Public Health
https://read.qxmd.com/read/38532238/pharmacological-basis-of-differences-in-dose-response-dose-equivalence-and-duration-of-action-of-inhaled-corticosteroids
#39
JOURNAL ARTICLE
Peter T Daley-Yates, Bhumika Aggarwal, Maximilian Plank
INTRODUCTION: Asthma treatment guidelines classify inhaled corticosteroid (ICS) regimens as low, medium, or high dose. However, efficacy and safety are not independently assessed accordingly. Moreover, differences in ICS duration of action are not considered when a dose regimen is selected. We investigated the efficacy and safety implications of these limitations for available ICS molecules. METHODS: Published pharmacodynamic and pharmacokinetic parameters were used, alongside physiological and pharmacological principles, to estimate the efficacy and safety of available ICS molecules...
March 27, 2024: Advances in Therapy
https://read.qxmd.com/read/38532172/simulating-cerebral-edema-and-ischemia-after-traumatic-acute-subdural-hematoma-using-triphasic-swelling-biomechanics
#40
JOURNAL ARTICLE
Andrew V Basilio, Delin Zeng, Leanne A Pichay, Gerard A Ateshian, Peng Xu, Steve A Maas, Barclay Morrison
Poor outcome following traumatic acute subdural hematoma (ASDH) is associated with the severity of the primary injury and secondary injury including cerebral edema and ischemia. However, the underlying secondary injury mechanism contributing to elevated intracranial pressure (ICP) and high mortality rate remains unclear. Cerebral edema occurs in response to the exposure of the intracellular fixed charge density (FCD) after cell death, causing ICP to increase. The increased ICP from swollen tissue compresses blood vessels in adjacent tissue, restricting blood flow and leading to ischemic damage...
March 26, 2024: Annals of Biomedical Engineering
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