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https://www.readbyqxmd.com/read/27922968/role-of-apoptosis-in-the-pathogenesis-of-nasal-polyps-based-upon-galectin-3-expression
#1
Taliye Cakabay, Ibrahim Sayin, Omer Erdur, Ali Muhammedoglu, Nihal Seden Tekke, Fatma Tulin Kayhan
OBJECTIVE: The authors aimed to investigate the antiapoptotic mechanisms in nasal polyps that occur after glandular hyperplasia. STUDY DESIGN: Retrospective histopathological analyses of patients with nasal polyps. METHODS: The study comprised 54 patients (19 females; 35 males). Group-1 patients with a diagnosis of nasal polyposis; group-2 patients with a diagnosis of antrochoanal polyps; group-3 with a diagnosis of deviation of the nasal septum as a control group...
December 5, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27922925/update-on-nonmalignant-lesions-of-the-inferior-turbinate
#2
Jared M Goldfarb, David Goldfarb, Marc R Rosen
PURPOSE OF REVIEW: The inferior turbinates are routinely examined by otolaryngologists on anterior rhinoscopy and nasal endoscopy. Most lesions of the inferior turbinate are benign but can often be confused with malignancy. This review highlights the broad differential of nonmalignant lesions of the inferior turbinates and their management. RECENT FINDINGS: A variety of infectious, inflammatory, neoplastic, and vascular lesions may affect the inferior turbinates...
December 5, 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27922519/a-giant-benign-polyp-of-the-stomach
#3
Omer Ozturk, Seyfettin Koklu, Cenk Sokmensuer, Halt Uner
No abstract text is available yet for this article.
November 2016: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
https://www.readbyqxmd.com/read/27922483/clinicopathologic-and-prognostic-significance-of-gelatinase-a-in-tunisian-colorectal-cancer-a-case-control-study
#4
Dalel Ben Néjima, Yosr Ben Zarkouna, Pascal Pujol, Amor Gammoudi, Hamouda Boussen, Mohamed Manai
Matrix metalloproteinase-2 (gelatinase A) is a well-known mediator of cancer metastasis, but it is also thought to be involved in several aspects of cancer development, including cell growth and inflammation. In the present study, we investigate whether MMP-2 SNP, MMP-2 mRNAs, and MMP-2 protein are associated with the susceptibility to colorectal cancer in the Tunisian population. The TaqMan allele discrimination assay and DNA sequencing techniques were used for genotyping; MMP-2 expression of each genotype was analyzed by semiquantitative RT-PCR, and MMP-2 protein expression was analyzed by immunohistochemistry staining...
January 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27922025/water-exchange-method-significantly-improves-adenoma-detection-rate-a-multicenter-randomized-controlled-trial
#5
Hui Jia, Yanglin Pan, Xuegang Guo, Lina Zhao, Xiangping Wang, Linhui Zhang, Tao Dong, Hui Luo, Zhizheng Ge, Jun Liu, Jianyu Hao, Ping Yao, Yao Zhang, Hongyu Ren, Weizhen Zhou, Yujie Guo, Wei Zhang, Xiaolin Chen, Dayong Sun, Xiaoqiang Yang, Xiaoyu Kang, Na Liu, Zhiguo Liu, Felix Leung, Kaichun Wu, Daiming Fan
OBJECTIVES: Adenoma detection rate (ADR) is a key colonoscopy quality indicator in Western clinical literature. Our low ADR prompted us to assess novel methods to improve performance. Western retrospective reports suggested that water exchange (WE) could increase ADR. However, most of these studies used pain score or intubation rate as the primary outcome. Here we test the hypothesis that WE significantly increases ADR among Chinese colonoscopists and design a prospective randomized controlled trial using ADR as our primary outcome...
December 6, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27920846/three-dimensional-computed-tomography-rendering-of-pedunculated-colon-polyp-new-clapper-bell-sign-pedunculated-polyp-at-3d-computed-tomography
#6
Marco Di Serafino, Rosa Severino, Fabia Laviani, Domenico Maroscia
The incidental detection of a tubulovillous adenoma at a contrast-enhanced computed tomography (CECT) with nondedicated protocol, performed in emergency conditions, is an uncommon finding. We report a case of a woman presenting with a subocclusive episode. A CECT scan was performed, and a pedunculated polyp could be appreciated at 3D-reconstruction images. A particular depiction of pedunculus of the polypoid lesion, resemble a clapper-bell, could help to define the vegetating lesion at the volume-rendering reconstruction images...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27920699/asymptomatic-multiple-lymphomatous-polyposis-identified-during-staging-bidirectional-endoscopy-of-mantle-cell-lymphoma
#7
Sonja P Dawsey, Jason A Gregory, Alexander W Brown, Frances J Jones
Multiple lymphomatous polyposis (MLP) as an extranodal manifestation of mantle cell lymphoma (MCL) in the gastrointestinal tract is rare and not often reported in the literature. We describe the case of a 63-year-old female with asymptomatic MLP found during staging bidirectional endoscopy of MCL. The patient presented only with dyspnea, but was found on physical exam to have diffuse lymphadenopathy, and subsequent positron emission tomography (PET) CT showed extensive lymph node adenopathy consistent with lymphoma...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27920485/use-of-the-endocuff-during-routine-colonoscopy-examination-improves-adenoma-detection-a-meta-analysis
#8
Matthew Chin, William Karnes, M Mazen Jamal, John G Lee, Robert Lee, Jason Samarasena, Matthew L Bechtold, Douglas L Nguyen
AIM: To perform meta-analysis of the use of Endocuff during average risk screening colonoscopy. METHODS: Scopus, Cochrane databases, MEDLINE/PubMed, and CINAHL were searched in April 2016. Abstracts from Digestive Disease Week, United European Gastroenterology, and the American College of Gastroenterology meeting were also searched from 2004-2015. Studies comparing EC-assisted colonoscopy (EAC) to standard colonoscopy, for any indication, were included in the analysis...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27920116/frequency-of-a-positive-family-history-of-colorectal-cancer-in-general-practice-a-cross-sectional-study
#9
Jasper Plath, Andrea Siebenhofer, Insa Koné, Marlene Hechtner, Sylvia Schulz-Rothe, Martin Beyer, Ferdinand M Gerlach, Corina Guethlin
BACKGROUND: Evidence on the frequency of a positive family history of colorectal cancer (CRC) among individuals aged <55 years is lacking. General practice setting might be well suited for the identification of individuals in this above-average risk group. OBJECTIVE: To determine the frequency of a reported positive family history of CRC among patients aged 40 to 54 years in a general practice setting. METHODS: We conducted a cross-sectional study in 21 general practices in Germany...
December 5, 2016: Family Practice
https://www.readbyqxmd.com/read/27919988/up-regulation-of-cytoplasmic-cd24-expression-is-associated-with-malignant-transformation-but-favorable-prognosis-of-colorectal-adenocarcinoma
#10
Min-Kyung Yeo, Yong-Moon Lee, In-Ock Seong, Song-Yi Choi, Kwang-Sun Suh, Kyu Sang Song, Choong-Sik Lee, Jin Man Kim, Kyung-Hee Kim
AIM: Cluster of differentiation 24 (CD24) is known to be a putative marker of stem cell and tumor metastasis. This study aimed to verify the clinicopathological value of CD24 expression in colorectal adenocarcinoma (CRAC). MATERIALS AND METHODS: A total of seven whole-tissue sections of malignant polyps including the sequence non-neoplastic colorectal tissue-adenoma-CRAC, 48 adenomas and 161 CRACs arranged as tissue microarray were examined by immunohistochemistry for CD24 protein expression...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27918709/spectral-photon-counting-ct-initial-experience-with-dual-contrast-agent-k-edge-colonography
#11
Daniela Muenzel, Daniel Bar-Ness, Ewald Roessl, Ira Blevis, Matthias Bartels, Alexander A Fingerle, Stefan Ruschke, Philippe Coulon, Heiner Daerr, Felix K Kopp, Bernhard Brendel, Axel Thran, Michal Rokni, Julia Herzen, Loic Boussel, Franz Pfeiffer, Roland Proksa, Ernst J Rummeny, Philippe Douek, Peter B Noël
Purpose To investigate the feasibility of using spectral photon-counting computed tomography (CT) to differentiate between gadolinium-based and nonionic iodine-based contrast material in a colon phantom by using the characteristic k edge of gadolinium. Materials and Methods A custom-made colon phantom was filled with nonionic iodine-based contrast material, and a gadolinium-filled capsule representing a contrast material-enhanced polyp was positioned on the colon wall. The colon phantom was scanned with a preclinical spectral photon-counting CT system to obtain spectral and conventional data...
December 2, 2016: Radiology
https://www.readbyqxmd.com/read/27918452/light-dark-shifting-promotes-alcohol-induced-colon-carcinogenesis-possible-role-of-intestinal-inflammatory-milieu-and-microbiota
#12
Faraz Bishehsari, Abdulrahman Saadalla, Khashayarsha Khazaie, Phillip A Engen, Robin M Voigt, Brandon B Shetuni, Christopher Forsyth, Maliha Shaikh, Martha Hotz Vitaterna, Fred Turek, Ali Keshavarzian
BACKGROUND: Colorectal cancer (CRC) is associated with the modern lifestyle. Chronic alcohol consumption-a frequent habit of majority of modern societies-increases the risk of CRC. Our group showed that chronic alcohol consumption increases polyposis in a mouse mode of CRC. Here we assess the effect of circadian disruption-another modern life style habit-in promoting alcohol-associated CRC. METHOD: TS4Cre × adenomatous polyposis coli (APC)(lox468) mice underwent (a) an alcohol-containing diet while maintained on a normal 12 h light:12 h dark cycle; or (b) an alcohol-containing diet in conjunction with circadian disruption by once-weekly 12 h phase reversals of the light:dark (LD) cycle...
December 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27917224/rectal-inflammatory-fibroid-polyp-in-a-nigerian-case-report-brief-review-of-literature
#13
Oluyemi Aderemi, Awolola Nicholas
BACKGROUND: Inflammatory fibroid polyps are very unusual gastrointestinal tumours. Furthermore, their occurrence in the rectum is a rarity indeed. OBJECTIVE: To document this very rare pathologic entity in a patient from our region of Africa and highlight some pertinent clinical and pathologic aspects of the disease. CASE REPORT: We present a 59 year old Nigerian who had neither significant previous medical history nor current complaint and had a routine colonoscopy done...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27914969/endometrial-polyps-and-abnormal-uterine-bleeding-aub-p-what-is-the-relationship-how-are-they-diagnosed-and-how-are-they-treated
#14
REVIEW
T Justin Clark, Helen Stevenson
The diagnosis and treatment of endometrial polyps will be familiar to most gynaecologists. However, the aetiology and natural history of these focal intrauterine lesions are yet to be elucidated. This lack of clarity is also true with regard to their clinical significance; whilst endometrial polyps are highly prevalent in all types of abnormal uterine bleeding (AUB), they are also commonly found in women without AUB. These controversies will be discussed along with current thoughts on the diagnosis and treatment of endometrial polyps...
October 1, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27913720/presentation-and-management-of-giant-fibrovascular-polyps-of-the-hypopharynx-and-esophagus
#15
Julina Ongkasuwan, C Lane Anzalone, Esperanza Salazar, Donald T Donovan
OBJECTIVE: Fibrovascular polyps of the hypopharynx and esophagus are rare, with few case reports in the literature. In this article, we present our institutional experience with a focus on airway and surgical management. STUDY DESIGN: Case series. SETTING: Tertiary academic institution. METHODS: A retrospective review was conducted of 4 patients that presented to a tertiary medical center with fibrovascular polyps between 1990 and 2012...
January 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27913447/comparison-of-oct-angiography-and-indocyanine-green-angiographic-findings-with-subtypes-of-polypoidal-choroidal-vasculopathy
#16
Koji Tanaka, Ryusaburo Mori, Akiyuki Kawamura, Hiroyuki Nakashizuka, Yu Wakatsuki, Mitsuko Yuzawa
PURPOSE: To compare the findings of optical coherence tomography angiography (OCTA) with indocyanine green angiography (ICGA) in polypoidal choroidal vasculopathy (PCV) that was divided into two types: polypoidal choroidal neovascularisation (CNV) and typical PCV (type 2 PCV). METHODS: We studied a retrospective case series of 32 patients with treatment-naïve PCV (24 men, eight women; mean age 65.4 years). PCV was categorised into polypoidal CNV (type 1 PCV) and type 2 PCV based on ICGA findings...
December 2, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27909808/clinical-validation-of-a-novel-urine-based-metabolomic-test-for-the-detection-of-colonic-polyps-on-chinese-population
#17
Lu Deng, Hong Fang, Victor K Tso, Yuanyuan Sun, Rae R Foshaug, Spencer C Krahn, Fen Zhang, Yujie Yan, Huilin Xu, David Chang, Yong Zhang, Richard N Fedorak
PURPOSE: Colorectal cancer is the fifth leading cause of cancer-related deaths in China. When detected early, with the removal of adenomatous polyps, precursors of colorectal cancer, it is preventable. The aim of this study was to evaluate a novel urine-based metabolomic diagnostic test for the detection of adenomatous polyps, PolypDx™, that was originally developed and validated using 1000 samples from Canadian Cohort, on Chinese population. METHODS: Prospective urine samples were collected from 1000 participants undergoing colonoscopy examination, from March 2013 to July 2014 at Minhang District, Shanghai Centre for Disease Control and Prevention...
December 1, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27906163/expression-of-annexin-a10-in-serrated-polyps-predicts-the-development-of-metachronous-serrated-polyps
#18
Carole Macaron, Rocio Lopez, Rish K Pai, Carol A Burke
OBJECTIVES: The ability to differentiate histological characteristics between serrated polyps (SPs) and make a pathological diagnosis of a sessile serrated polyp (SSP) is highly variable. Recent studies have shown that immunohistochemical (IHC) expression of Annexin A10 (ANXA10) is a marker of a SSP. However, the clinical utility of ANXA10 expression in patients with SPs is unknown. The objective of this study was to evaluate the utility of ANXA10 expression in SPs in predicting the development of subsequent polyps at follow-up colonoscopy...
December 1, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27905661/artificial-cartilage-bio-matrix-formed-of-hyaluronic-acid-and-mg2-polyphosphate
#19
X Wang, M Ackermann, E Tolba, M Neufurth, F Wurm, Q Feng, S Wang, H C Schröder, W E Müller
Here we show that inorganic polyphosphate (polyP), a polyanionic metabolic regulator consisting of multiple phosphate residues linked by energy-rich phosphoanhydride bonds, is present in the synovial fluid. In a biomimetic approach, to enhance cartilage synthesis and regeneration, we prepared amorphous polyP microparticles with Mg2+ as counterions. The particles were characterised by X-ray diffraction (XRD), energy-dispersive X-ray (EDX) and Fourier transformed infrared spectroscopic (FTIR) analyses. Similar particles were obtained after addition of Mg2+ ions to a solution containing hyaluronic acid, as a major component of the synovial fluid, and soluble Na-polyP...
November 29, 2016: European Cells & Materials
https://www.readbyqxmd.com/read/27904953/endometrial-preparation-with-dienogest-before-hysteroscopic-surgery-a-systematic-review
#20
Antonio Simone Laganà, Salvatore Giovanni Vitale, Vincenzo Muscia, Paola Rossetti, Massimo Buscema, Onofrio Triolo, Agnese Maria Chiara Rapisarda, Loretta Giunta, Vittorio Palmara, Roberta Granese, Helena Ban Frangež, Andrea Romano
PURPOSE: Hysteroscopic surgery is considered the gold standard for the minimal invasive treatment of many endouterine diseases such as endometrial polyps or submucous myomas. Recently, many studies have evaluated the effect of preoperative administration of a number of drugs to reduce endometrial thickness and achieve important intraoperative advantages. The purpose of this systematic review is to summarize the available evidence about the use of Dienogest, an orally administrable progestin, for endometrial preparation before hysteroscopic surgery...
November 30, 2016: Archives of Gynecology and Obstetrics
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