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temporal epilepsy in children

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https://www.readbyqxmd.com/read/29905152/epileptic-seizure-semiology-in-different-age-groups
#1
Guadalupe Fernandez-Baca Vaca, Carlos L Mayor, Naira García Losarcos, Jun T Park, Hans O Lüders
Seizure semiology provides information about the eloquent cortex involved during a seizure and helps to generate a hypothesis regarding the localization of the epileptogenic zone (EZ), a prerequisite for surgical management of epilepsy. We aimed to study the seizure semiology among all different age groups to better characterize semiological changes that occur with age. We performed a retrospective review of video-EEG data in paediatric and adult patients admitted to the Epilepsy Monitoring Unit over a three-year period...
June 15, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29898967/european-trends-in-epilepsy-surgery
#2
Maxime O Baud, Thomas Perneger, Attila Rácz, Max C Pensel, Christian Elger, Bertil Rydenhag, Kristina Malmgren, J Helen Cross, Grainne McKenna, Martin Tisdall, Herm J Lamberink, Sylvain Rheims, Philippe Ryvlin, Jean Isnard, François Mauguière, Alexis Arzimanoglou, Serdar Akkol, Kaancan Deniz, Cigdem Ozkara, Morten Lossius, Ivan Rektor, Reetta Kälviäinen, Lotta-Maria Vanhatalo, Petia Dimova, Krassimir Minkin, Anke Maren Staack, Bernhard J Steinhoff, Adam Kalina, Pavel Krsek, Petr Marusic, Zsofia Jordan, Daniel Fabo, Evelien Carrette, Paul Boon, Saulius Rocka, Rūta Mameniškienė, Serge Vulliemoz, Francesca Pittau, Kees P J Braun, Margitta Seeck
OBJECTIVE: Resective surgery is effective in treating drug-resistant focal epilepsy, but it remains unclear whether improved diagnostics influence postsurgical outcomes. Here, we compared practice and outcomes over 2 periods 15 years apart. METHODS: Sixteen European centers retrospectively identified 2 cohorts of children and adults who underwent epilepsy surgery in the period of 1997 to 1998 (n = 562) or 2012 to 2013 (n = 736). Data collected included patient (sex, age) and disease (duration, localization and diagnosis) characteristics, type of surgery, histopathology, Engel postsurgical outcome, and complications, as well as imaging and electrophysiologic tests performed for each case...
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29881798/epilepsy-after-perinatal-stroke-with-different-vascular-subtypes
#3
Rael Laugesaar, Ulvi Vaher, Silva Lõo, Anneli Kolk, Mairi Männamaa, Inga Talvik, Eve Õiglane-Shlik, Dagmar Loorits, Tiina Talvik, Pilvi Ilves
Objective: With an incidence up to 63 per 100,000 live births, perinatal stroke is an important cause of childhood epilepsy. The aim of the study was to find the prevalence of and predictive factors for epilepsy, and to describe the course of epilepsy in children with perinatal stroke with different vascular subtypes. Methods: Patients were retrieved from the Estonian Paediatric Stroke Database with follow-up time at least 24 months. Patients were divided into 5 perinatal stroke syndromes: neonatal arterial ischemic stroke (AIS), neonatal hemorrhagic stroke, neonatal cerebral sinovenous thrombosis, presumed AIS, and presumed periventricular venous infarction...
June 2018: Epilepsia Open
https://www.readbyqxmd.com/read/29880477/thalamocortical-connections-and-executive-function-in-pediatric-temporal-and-frontal-lobe-epilepsy
#4
N Law, M L Smith, E Widjaja
BACKGROUND AND PURPOSE: Largely accepted in the literature is the role the interconnections between the thalamus and cortex play in generalized epilepsy. However, thalamocortical involvement is less understood in focal epilepsy in terms of the effect of seizures on thalamocortical circuitry in the developing brain and subsequent cognitive outcome. We investigated thalamocortical pathway microstructure in pediatric frontal lobe epilepsy and temporal lobe epilepsy and examined the associations between pathway microstructure and measures of executive function...
June 7, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29793594/electroencephalographic-markers-of-brain-development-during-sevoflurane-anaesthesia-in-children-up-to-3-years-old
#5
L Cornelissen, S E Kim, J M Lee, E N Brown, P L Purdon, C B Berde
BACKGROUND: General anaesthetics generate spatially defined brain oscillations in the EEG that relate fundamentally to neural-circuit architecture. Few studies detailing the neural-circuit activity of general anaesthesia in children have been described. The study aim was to identify age-related changes in EEG characteristics that mirror different stages of early human brain development during sevoflurane anaesthesia. METHODS: Multichannel EEG recordings were performed in 91 children aged 0-3 yr undergoing elective surgery...
June 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29786811/-50-percent-of-patients-who-had-epilepsy-surgery-are-seizure-free
#6
Anna Edelvik, Ingrid B Olsson, Tove Hallbook, Kristina Malmgren
About one third of patients with epilepsy do not become seizure-free despite medication. For some, resective epilepsy surgery is the treatment of choice. There are three randomized controlled trials, with positive results at a follow-up of 1-2 years: two on temporal lobe resections on adults and young people and one on all types of epilepsy surgery on children. Since 1990 all epilepsy surgery procedures in Sweden are reported to the Swedish Epilepsy Surgery Register, now with data on almost 1500 patients. Two years after surgery about 50% of adults and children are seizure-free, and another 10% have been so during the last year...
May 22, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29748835/canonical-transient-receptor-potential-channel-3-contributes-to-febrile-seizure-inducing-neuronal-cell-death-and-neuroinflammation
#7
Dan Sun, Hui Ma, Jiehui Ma, Jing Wang, Xiaolong Deng, Chunhui Hu, Xianbo Deng
Febrile seizure (FS) counts as the most common seizures symptom in children undergoing recurrent seizures, posing a high risk to developing subsequent temporal lobe epilepsy. Canonical transient receptor potential channel (TRPC) members are identified as the FS-related genes in hyperthermia prone rats. However, the role of TRPC3 in hyperthermia-induced FS rats remains unclear. In the present study, we investigated whether TRPC3 functionally contributes to the development of FSs. Elevated TRPC3 mRNA and protein levels was detected in hyperthermia-induced FS rats and rat hippocampal neuron cells...
May 10, 2018: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29730171/small-intraneuronal-acidification-via-short-chain-monocarboxylates-first-evidence-of-an-inhibitory-action-on-over-excited-human-neocortical-neurons
#8
Udo Bonnet, Dieter Bingmann, Erwin-Josef Speckmann, Martin Wiemann
AIMS: In cortical mammalian neurons, small fluctuations of intracellular pH (pHi) play a crucial role for inter- and intracellular signaling as well as for cellular and synaptic plasticity. Yet, there have been no respective data about humans. Thus, we investigated the interrelation of pHi and excitability of human cortical neurons. MATERIALS AND METHODS: Intracellular electrophysiological and pH-recordings were made in neurons in slices taken from brain tissue resected from the middle temporal gyrus of two male children (26 months and 35 months old) who suffered from pharmacotherapy-resistant temporal lobe epilepsy...
May 3, 2018: Life Sciences
https://www.readbyqxmd.com/read/29708173/uncertainties-from-a-worldwide-survey-on-antiepileptic-drug-withdrawal-after-seizure-remission
#9
Luca Bartolini, Shahram Majidi, Mohamad Z Koubeissi
Background: We sought to determine differences in practice for discontinuation of antiepileptic drugs (AEDs) after seizure remission and stimulate the planning and conduction of withdrawal trials. Methods: We utilized a worldwide electronic survey that included questions about AED discontinuation for 3 paradigmatic cases in remission: (1) focal epilepsy of unknown etiology, (2) temporal lobe epilepsy after surgery, and (3) juvenile myoclonic epilepsy. We analyzed 466 complete questionnaires from 53 countries, including the United States...
April 2018: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29705623/pediatric-epilepsies-misdiagnosed-as-gastrointestinal-disorders
#10
Giulia Carbonari, Giacomo Tonti, Veronica Di Pisa, Emilio Franzoni, Duccio Maria Cordelli
In the last years, several cases of pediatric epilepsies misdiagnosed and treated as gastrointestinal (GI) disorders have been reported. The aim of this study was to evaluate both frequency and characteristics of these erroneous diagnoses. We identified children who had received a previous misdiagnosis of GI disorder out of 858 consecutive patients with a diagnosis of epilepsy at our hospital from 2010 to 2015. Misdiagnosis was observed in 21 patients (2.4%): 7 children with West syndrome, 10 with temporal lobe epilepsy, and 4 with Panayiotopoulos syndrome...
June 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29685768/accelerated-long-term-forgetting-and-behavioural-difficulties-in-children-with-epilepsy
#11
Michael B Gascoigne, Mary Lou Smith, Belinda Barton, Richard Webster, Deepak Gill, Suncica Lah
Patients with epilepsy have been shown to exhibit a range of memory deficits, including the rapid forgetting of newly-learned material over long, but not short, delays (termed accelerated long-term forgetting; ALF). Behavioural problems, such as mood disorders and social difficulties, are also overrepresented among children with epilepsy, when compared to patients with other chronic diseases and the general population. We investigated whether ALF was associated with behavioural or psychosocial deficits in children with epilepsy...
March 30, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29668992/pediatric-temporal-lobe-epilepsy-surgery-in-bonn-and-review-of-the-literature
#12
D Ryan Ormond, Hans Clusmann, Robert Sassen, Christian Hoppe, Christoph Helmstaedter, Johannes Schramm, Alexander Grote
BACKGROUND: Epilepsy surgery is well established as safe and successful for children with temporal lobe epilepsy (TLE). Despite evidence from available data, there remains some reluctance to refer children with medically refractory epilepsy for preoperative evaluation and workup for possible surgery. OBJECTIVE: To present the largest case series of pediatric (TLE) patients thus far, in order to better understand the predictability of preoperative evaluation on seizure outcome, and to better understand longitudinal outcomes in a large pediatric cohort...
April 13, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29629540/role-of-language-related-functional-connectivity-in-patients-with-benign-childhood-epilepsy-with-centrotemporal-spikes
#13
Hyeon Jin Kim, Jung Hwa Lee, Chang Hyun Park, Hye Sun Hong, Yun Seo Choi, Jeong Hyun Yoo, Hyang Woon Lee
BACKGROUND AND PURPOSE: Benign childhood epilepsy with centrotemporal spikes (BECTS) does not always have a benign cognitive outcome. We investigated the relationship between cognitive performance and altered functional connectivity (FC) in the resting-state brain networks of BECTS patients. METHODS: We studied 42 subjects, comprising 19 BECTS patients and 23 healthy controls. Cognitive performance was assessed using the Korean version of the Wechsler Intelligence Scale for Children-III, in addition to verbal and visuospatial memory tests and executive function tests...
January 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29610055/language-function-in-childhood-idiopathic-epilepsy-syndromes
#14
D C Jackson, J E Jones, D A Hsu, C E Stafstrom, J J Lin, D Almane, M A Koehn, M Seidenberg, B P Hermann
PURPOSE: To examine the impact of diverse syndromes of focal and generalized epilepsy on language function in children with new and recent onset epilepsy. Of special interest was the degree of shared language abnormality across epilepsy syndromes and the unique effects associated with specific epilepsy syndromes. METHODS: Participants were 136 youth with new or recent-onset (diagnosis within past 12 months) epilepsy and 107 healthy first-degree cousin controls...
March 30, 2018: Brain and Language
https://www.readbyqxmd.com/read/29573759/executive-dysfunction-and-depression-in-pediatric-temporal-lobe-epilepsy-the-contribution-of-hippocampal-sclerosis-and-psychosocial-factors
#15
William A Schraegle, Nancy L Nussbaum, Jeffrey B Titus
OBJECTIVES: Temporal lobe epilepsy (TLE) has been identified as a risk factor for increased depression features in children and adolescents; however, less is known regarding specific neurocognitive predictors of depression in this population above and beyond seizure-specific and sociodemographic factors. METHODS: The study included 62 patients with TLE (64% male) aged 8 to 16 years (M=12.62; SD=2.26) who underwent comprehensive neuropsychological evaluation. RESULTS: Correlation analyses revealed significant association between patient depression and WCST Total Perseverations, BRIEF Behavioral Regulation Index (BRI) and family stress...
March 25, 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29571057/panayiotopoulos-syndrome-and-benign-partial-epilepsy-with-centro-temporal-spikes-a-comparative-incidence-study
#16
Elaine Weir, John Gibbs, Richard Appleton
PURPOSE: To compare the de novo incidence of Panayiotopoulos syndrome (PS, early-onset childhood occipital epilepsy) and a common epilepsy syndrome, benign epilepsy with centro-temporal spikes (BECTS), in children and young people. METHODS: The incidence of PS and BECTS was recorded over 16 months in a population of children and young people (aged <16 years) living within a specific geographic area and epilepsy network within the North West of England and North Wales and the catchment area of the tertiary paediatric epilepsy centre...
April 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29525400/safety-and-effectiveness-of-surgery-for-epilepsy-in-children-experience-of-a-tertiary-hospital-in-ecuador
#17
O Fernández-Concepción, M López Jiménez, C Valencia-Calderón, A Calderón-Valdivieso, A Recasén-Linares, L Reyes-Haro, C Vásquez-Ham
INTRODUCTION: There is sufficient evidence on the usefulness of surgery as a therapeutic alternative for patients with drug-resistant epilepsy; however this treatment is underutilized, especially in developing countries. METHODS: We describe the outcomes of epilepsy surgery in 27 paediatric patients at Hospital Baca Ortiz in Quito, Ecuador. Our analysis considered the following variables: reduction in seizure frequency, surgery outcome according to the Engel classification, improvement in quality of life, and serious complications due to surgery...
March 7, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29518249/characteristics-and-long-term-outcome-of-127-children-with-cerebral-arteriovenous-malformations
#18
Elias Oulasvirta, Päivi Koroknay-Pál, Ahmad Hafez, Ahmed Abou Elseoud, Hanna Lehto, Aki Laakso
BACKGROUND: Population-based long-term data on pediatric patients with cerebral arteriovenous malformations (AVMs) are limited. OBJECTIVE: To clarify the characteristics and long-term outcome of pediatric patients with AVM. METHODS: A retrospective analysis was performed on 805 consecutive brain AVM patients admitted to a single center between 1942 and 2014. The patients were defined as children if they were under 18 yr at admission. Children were compared to an adult cohort...
March 5, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29467710/structural-covariance-network-of-cortical-gyrification-in-benign-childhood-epilepsy-with-centrotemporal-spikes
#19
Lin Jiang, Tijiang Zhang, Fajin Lv, Shiguang Li, Heng Liu, Zhiwei Zhang, Tianyou Luo
Benign childhood epilepsy with centrotemporal spikes (BECTS) is associated with cognitive and language problems. According to recent studies, disruptions in brain structure and function in children with BECTS are beyond a Rolandic focus, suggesting atypical cortical development. However, previous studies utilizing surface-based metrics (e.g., cortical gyrification) and their structural covariance networks at high resolution in children with BECTS are limited. Twenty-six children with BECTS (15 males/11 females; 10...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29462779/effects-of-vagus-nerve-stimulation-on-heart-rate-variability-in-children-with-epilepsy
#20
Tugba Hirfanoglu, Ayse Serdaroglu, Ilker Cetin, Gokhan Kurt, Irem Y Capraz, Filiz Ekici, Ebru Arhan, Erhan Bilir
PURPOSE: The aim of this study was to evaluate the effects of vagus nerve stimulation (VNS) on heart rate variability (HRV) in children with epilepsy. METHODS: The subgroups of HRV, namely time domain (Standard deviation of NN interval (SDNN), SDNN index, Standard deviation of the averages of NN intervals (SDANN), Root mean square of successive differences (RMMSD), Adjacent NN intervals differing by more than 50 ms in the entire recording divided by the total number of all NN intervals (PNN50), triangular index) and frequency domain (Low-frequency (LF), High-frequency (HF), LF/HF), were investigated in 20 pediatric patients before and after 6 and 12months of VNS treatment during day and night by comparing their data with those of 20 control subjects...
April 2018: Epilepsy & Behavior: E&B
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