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temporal epilepsy in children

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https://www.readbyqxmd.com/read/29450813/memory-rehabilitation-in-patients-with-epilepsy-a-systematic-review
#1
REVIEW
Samantha Joplin, Elizabeth Stewart, Michael Gascoigne, Suncica Lah
Memory failure is a common clinical concern of patients with epilepsy and is associated with significant functional impairments. Thus, memory rehabilitation is of critical clinical importance. In this article, we aimed to systematically evaluate the efficacy of memory rehabilitation in patients with epilepsy. The Preferred Items for Systematic Reviews and Meta-Analyses (PRISMA) was used to guide searches, extraction and reporting of data in this review. PsycINFO, Medline and PsychBITE searches yielded 95 studies...
February 15, 2018: Neuropsychology Review
https://www.readbyqxmd.com/read/29414546/unique-and-shared-areas-of-cognitive-function-in-children-with-intractable-frontal-or-temporal-lobe-epilepsy
#2
Nicole Law, Elysa Widjaja, Mary Lou Smith
OBJECTIVE: Previous findings have been mixed in terms of identifying a distinct pattern of neuropsychological deficits in children with frontal lobe epilepsy (FLE) and in those with temporal lobe epilepsy (TLE). The current study investigated the neuropsychological similarities and differences across these two pediatric medically intractable localization-related epilepsies. METHOD: Thirty-eight children with FLE, 20 children with TLE, and 40 healthy children (HC) participated in this study...
January 25, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29393811/treatment-of-medically-refractory-seizures-with-responsive-neurostimulation-2-pediatric-cases
#3
Malgosia A Kokoszka, Fedor Panov, Maite La Vega-Talbott, Patricia E McGoldrick, Steven M Wolf, Saadi Ghatan
The responsive neurostimulation (RNS) system, an adjunctive treatment for pharmacoresistant partial-onset seizures with 1 or 2 foci, has been available to patients aged 18 years or older since the device's FDA approval in 2013. Herein, the authors describe their off-label application of this technology in 2 pediatric patients and the consequent therapeutic benefit without surgical complications or treatment side effects. A 14-year-old nonambulatory, nonverbal male with severe developmental delay was considered for RNS therapy for medically and surgically refractory epilepsy with bilateral seizure onsets in the setting of a normal radiological examination and a known neuropathological diagnosis of type I cortical dysplasia...
February 2, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29367145/pre-ictal-heart-rate-changes-a-systematic-review-and-meta-analysis
#4
Elisa Bruno, Andrea Biondi, Mark P Richardson
PURPOSE: To estimate the incidence of pre-ictal heart rate (HR) manifestations and to identify clinical and study-related factors modulating the estimate. METHODS: We searched articles recording concurrent pre-ictal EEG and HR in adults and children with epilepsy. Pre-ictal HR changes were classified as HR reduction (HRR) or increase (HRI). Studies reporting the total number of seizures and the number of seizures with pre-ictal HR changes were included in a random-effects meta-analysis...
January 8, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29352627/indications-and-limits-of-stereoelectroencephalography-seeg
#5
REVIEW
Lorella Minotti, Alexandra Montavont, Julia Scholly, Louise Tyvaert, Delphine Taussig
Epilepsy surgery is now an accepted treatment to achieve seizure control in carefully selected patients, both children and adults, suffering from drug-resistant focal epilepsy. Although surgical strategies can often be defined on the basis of non-invasive diagnostic procedures, and despite the recent advances in this field, an increasing number of more complex cases requires invasive EEG (iEEG) to provide precise information on the localization of the epileptogenic zone (EZ), its relationships with eloquent cortex (EC), and the feasibility of a tailored surgical resection...
January 15, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29305185/predictors-of-outcome-after-surgery-in-134-children-with-drug-resistant-tle
#6
Ashalatha Radhakrishnan, Ramshekhar Menon, Mathew Abraham, George Vilanilam, Suvasini Sharma, Bejoy Thomas, Chandrashekharan Kesavadas, Ajith Cherian, Raviprasad Varma, Sanjeev V Thomas
PURPOSE: To determine the factors predicting seizure outcome in children who underwent anterior temporal lobectomy (ATL) for drug-resistant temporal lobe epilepsy (TLE). METHODS: Among the 664 patients who underwent ATL for TLE from 1995 to 2008, there were 134 children. "Excellent" outcome in them was defined as seizure freedom during the entire follow-up (Engel class I a); "good outcome", if in remission last 2 years, and the rest as "unfavorable outcome". To identify the potential predictors of seizure recurrence, the attributes of recurred and non-recurred groups was compared by univariate and multivariate analysis...
January 2, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29303866/pet-and-ictal-spect-can-be-helpful-for-localizing-epileptic-foci
#7
Tim J von Oertzen
PURPOSE OF REVIEW: Functional neuroimaging with PET and SPECT is a commonly used tool in presurgical evaluation. The following article reviews the literature of PET and SPECT in presurgical assessment of epilepsies published in the last year. RECENT FINDINGS: FDG-PET adds concomitant information in temporal and extratemporal lobe epilepsy in adults and children. The pattern of hypometabolism in FDG-PET is a good additional predictor or seizure outcome in TLE with mesial temporal sclerosis or negative MRI...
January 4, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29274110/metabolic-correlates-of-cognitive-function-in-children-with-unilateral-sturge-weber-syndrome-evidence-for-regional-functional-reorganization-and-crowding
#8
Jeong-A Kim, Jeong-Won Jeong, Michael E Behen, Vinod K Pilli, Aimee Luat, Harry T Chugani, Csaba Juhász
To evaluate metabolic changes in the ipsi- and contralateral hemisphere in children showing a cognitive profile consistent with early reorganization of cognitive function, we evaluated the regional glucose uptake, interhemispheric metabolic connectivity, and cognitive function in children with unilateral SWS. Interictal 2-deoxy-2[18 F]fluoro-D-glucose (FDG)-PET scans of 27 children with unilateral SWS and mild epilepsy and 27 age-matched control (non-SWS children with epilepsy and normal FDG-PET) were compared using statistical parametric mapping (SPM)...
December 23, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29223007/examining-health-service-utilization-hospital-treatment-cost-and-mortality-of-individuals-with-epilepsy-and-status-epilepticus-in-new-south-wales-australia-2012-2016
#9
Rebecca J Mitchell, Geoffrey Herkes, Armin Nikpour, Andrew Bleasel, Patti Shih, Sanjyot Vagholkar, Frances Rapport
This study examined the health service utilization and hospital treatment cost of individuals with epilepsy by age group, mortality within 30days, and surgical outcomes for individuals with refractory epilepsy in New South Wales (NSW), Australia. A retrospective examination of linked hospitalization and mortality data for individuals hospitalized with a diagnosis of epilepsy during 2012-2016. Hospitalized incidence rates per 1000 population were calculated, and negative binomial regression was used to examine temporal trends...
December 6, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29221514/yield-of-brain-mri-in-clinically-diagnosed-epilepsy-in-the-kingdom-of-bhutan-a-prospective-study
#10
Veronica Bruno, Joshua P Klein, Dechen Nidup, Damber K Nirola, Lhab Tshering, Sonam Deki, Sarah J Clark, Kristin A Linn, Russell T Shinohara, Chencho Dorji, Dili Ram Pokhrel, Ugyen Dema, Farrah J Mateen
BACKGROUND: People with epilepsy (PWE) in low- and middle-income countries may not access the health resources that are considered optimal for epilepsy diagnosis. The diagnostic yield of magnetic resonance imaging (MRI) has not been well studied in these settings. OBJECTIVES: To report the diagnostic yield of brain MRI and identify clinical associations of abnormal MRI findings among PWE in a neurocysticercosis-endemic, resource-limited setting and to identify the proportion and putative structural brain causes of drug-resistant epilepsy...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29069555/histopathological-findings-in-brain-tissue-obtained-during-epilepsy-surgery
#11
Ingmar Blumcke, Roberto Spreafico, Gerrit Haaker, Roland Coras, Katja Kobow, Christian G Bien, Margarete Pfäfflin, Christian Elger, Guido Widman, Johannes Schramm, Albert Becker, Kees P Braun, Frans Leijten, Johannes C Baayen, Eleonora Aronica, Francine Chassoux, Hajo Hamer, Hermann Stefan, Karl Rössler, Maria Thom, Matthew C Walker, Sanjay M Sisodiya, John S Duncan, Andrew W McEvoy, Tom Pieper, Hans Holthausen, Manfred Kudernatsch, H Joachim Meencke, Philippe Kahane, Andreas Schulze-Bonhage, Josef Zentner, Dieter H Heiland, Horst Urbach, Bernhard J Steinhoff, Thomas Bast, Laura Tassi, Giorgio Lo Russo, Cigdem Özkara, Buge Oz, Pavel Krsek, Silke Vogelgesang, Uwe Runge, Holger Lerche, Yvonne Weber, Mrinalini Honavar, José Pimentel, Alexis Arzimanoglou, Adriana Ulate-Campos, Soheyl Noachtar, Elisabeth Hartl, Olaf Schijns, Renzo Guerrini, Carmen Barba, Thomas S Jacques, J Helen Cross, Martha Feucht, Angelika Mühlebner, Thomas Grunwald, Eugen Trinka, Peter A Winkler, Antonio Gil-Nagel, Rafael Toledano Delgado, Thomas Mayer, Martin Lutz, Basilios Zountsas, Kyriakos Garganis, Felix Rosenow, Anke Hermsen, Tim J von Oertzen, Thomas L Diepgen, Giuliano Avanzini
BACKGROUND: Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy. METHODS: We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%)...
October 26, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29045978/-clinicopathologic-features-of-infant-dysembryoplastic-neuroepithelial-tumor-a-case-report-and-literature-review
#12
H Wang, J T Ye, H X Yao, D Li, Y Dong
Dysembryoplastic neuroepithelial tumor (DNT) has traditionally been viewed as rare benign tumors that present with seizure widely considered curable with surgery alone. Most DNTs occur in childhood and young adults. However, rare reported cases occur in infants. This paper reported an infant case of DNT and its diagnosis, differential diagnosis, treatment, molecular features and prognosis based on the review of current literatures. The age onset of this patient was only 11 months old. The clinical manifestations were partial seizures and the imaging data untypical; CT and MRI were all supportive of astrocytoma...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29032016/neuropsychological-outcomes-following-paediatric-temporal-lobe-surgery-for-epilepsies-evidence-from-a-systematic-review
#13
REVIEW
Alice E Flint, Mitch Waterman, Grace Bowmer, Gayatri Vadlamani, Paul Chumas, Matthew C H J Morrall
OBJECTIVE: The systematic review aimed to assess the neuropsychological outcomes of temporal lobe resections for epilepsy in children. Additional objectives included determining whether earlier age at surgery leads to better neuropsychological outcomes; the relationships between and predictors of these outcomes. METHODS: Using advanced search terms, a systematic review of electronic databases was conducted, comprising MEDLINE, Embase, PsycINFO, Global Health, Web of Science and CINAHL...
September 19, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29029800/surgical-treatment-of-neuronal-glial-tumors-of-mesial-basal-part-of-temporal-lobe-long-term-outcome-and-control-of-epilepsy-in-pediatric-patients
#14
Paweł Daszkiewicz, Paweł Kowalczyk, Marcin Roszkowski
BACKGROUND: Neuronal-glial tumors (ganglioglioma and dysembryoplastic neuroepithelial tumor) are a frequent cause of focal, drug-resistant and epilepsy in children and young adults, that is amenable for surgical treatment. AIM OF PAPER: Assessment of late outcome of surgical treatment and degree of seizure control, as well as prognostic significance of selected clinical factors. MATERIAL AND METHOD: 52 Pediatric patients presenting with epilepsy, lesion of mesio-basal temporal lobe and histologically verified neuronal-glial tumor treated at our facility since 2000-2011...
April 19, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29017082/temporal-lobe-surgery-for-intractable-epilepsy-in-children-what-to-do-with-the-hippocampus
#15
Mony Benifla, Odeya Bennet-Back, Zamir Shorer, Iris Noyman, Rima Bar-Yosef, Dana Ekstein
PURPOSE: Resection of the hippocampus can cause verbal memory decline, especially in the pediatric population. Thus, preservation of the hippocampus can be crucial for the quality of life of children with intractable temporal lobe epilepsy (TLE) who are candidates for epilepsy surgery. We investigated techniques that determine whether the hippocampus is part of the epileptogenic zone and the outcomes of pediatric surgery aimed to spare the hippocampus. METHODS: We accessed data of children with normal hippocampus on MRI, who underwent surgery for medically refractory TLE...
October 2, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28964596/mri-guided-stereotactic-laser-ablation-for-epilepsy-surgery-promising-preliminary-results-for-cognitive-outcome
#16
Daniel L Drane
Cognitive outcome data are reviewed with respect to the use of magnetic-resonance guided stereotactic laser ablation (SLA) as an epilepsy surgical procedure, with comparisons drawn to traditional open resection procedures. Cognitive outcome with stereotactic laser amygdalohippocampotomy (SLAH) appears better than open resection for several functions dependent on extra-mesial temporal lobe (TL) structures, including category-related naming, verbal fluency, and object/familiar person recognition. Preliminary data suggests episodic, declarative verbal memory can decline following SLAH in the language dominant hemisphere, although early findings suggest comparable or even superior outcomes compared with open resection...
September 23, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28963933/functional-surgery-in-pediatric-drug-resistant-posterior-cortex-epilepsy-electro-clinical-findings-cognitive-and-seizure-outcome
#17
A Sierra-Marcos, M C Fournier-Del Castillo, J Álvarez-Linera, M Budke, M García-Fernández, M A Pérez-Jiménez
PURPOSE: Epilepsies originated from the occipital, parietal and/or the posterior edge of the temporal lobe are grouped together into posterior cortex epilepsy (PCE). Our objective was firstly to describe electro-clinical and imaging findings in the presurgical evaluation of children with PCE, and secondly to identify potential factors associated with surgical and cognitive outcomes. METHOD: From the total of patients referred to the Epilepsy Monitoring Unit of 'Hospital Universitario Niño Jesús' from 2003 to 2016, 55 had drug-resistant PCE...
September 22, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28873364/refractory-spasms-of-focal-onset-a-potentially-curable-disease-that-should-lead-to-rapid-surgical-evaluation
#18
Mathilde Chipaux, Georg Dorfmüller, Martine Fohlen, Nathalie Dorison, Marie-Astrid Metten, Olivier Delalande, Sarah Ferrand-Sorbets, Delphine Taussig
PURPOSE: Infantile spasms (IS) can occur as the only seizure type in children with surgically amenable epilepsies. Although early surgery has shown positive effects, little is known regarding outcomes. METHODS: We retrospectively reviewed all children with IS referred to our tertiary center between 2002 and 2014 and try to define factors of outcome. RESULTS: Sixty-eight children with focal onset seizures were referred: twenty children with a hemispheric implication and 48 with one or more lobes involved...
October 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28859025/seizures-induced-by-exiting-water-a-unique-form-of-reflex-epilepsy
#19
Brian Appavu, Jordana Fox, Robert Little, John F Kerrigan, Makram Obeid
INTRODUCTION: Reflex epilepsies represent a form of epilepsy in which unique modes of seizure precipitation are characterized by endogenous or exogenous stimuli. Hot water epilepsy represents a subtype of reflex epilepsy in which seizure precipitation arises from the act of immersing the head with hot water. Bathing epilepsy represents another subtype of reflex epilepsy in which seizure precipitation arises from the immersion with water at lukewarm temperatures. CASE SERIES: We report on 2 boys with a unique form of bathing epilepsy characterized by the act of exiting out of water...
September 2017: Neurologist
https://www.readbyqxmd.com/read/28852255/temporal-lobe-seizures-presenting-as-abrupt-clinging-behavior-in-a-child
#20
Shabina A Sheth, Nilanjan C Chandra, Ritambhara Y Mehta
True and psychogenic nonepileptic seizures (PNES) go hand in hand. One colors the picture of other. Although it is thought that children carry lower risk for PNES than adults, this may represent the under-diagnosis of this condition in childhood due to few studies on this specific topic. Again, true seizure can be misdiagnosed by dramatic and varied manifestations appearing as psychological phenomena. We report a case of a 9-year-old boy presenting with sudden onset, short lasting, off and on different "melodramatic" episodic behavioral problems with La-Belle' indifference without loss of consciousness, appearing to be of psychogenic origin but finally ended with a diagnosis of temporal lobe epilepsy and responded dramatically with antiepileptics...
July 2017: Indian Journal of Psychological Medicine
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