Erin S Calipari, Arthur Godino, Marine Salery, Diane M Damez-Werno, Michael E Cahill, Craig T Werner, Amy M Gancarz, Emily G Peck, Zahra Jlayer, Jacqui Rabkin, Joseph A Landry, Alexander C W Smith, Paola Defilippi, Paul J Kenny, Yasmin L Hurd, Rachael L Neve, David M Dietz, Eric J Nestler
Addictive behaviors, including relapse, are thought to depend in part on long-lasting drug-induced adaptations in dendritic spine signaling and morphology in the nucleus accumbens (NAc). While the influence of activity-dependent actin remodeling in these phenomena has been studied extensively, the role of microtubules and associated proteins remains poorly understood. We report that pharmacological inhibition of microtubule polymerization in the NAc inhibited locomotor sensitization to cocaine and contextual reward learning...
May 15, 2019: Journal of Neuroscience