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Dong-Min Choi, Jin-Woo Kim, Se-Hee Park, Kyung-Mo Cho, Sang Won Kwak, Hyeon-Cheol Kim
INTRODUCTION: This study aimed to compare the vibration generated by several nickel-titanium (NiTi) file systems and transmitted to teeth under 2 different motions (continuous rotation motion and reciprocating motion). METHODS: Sixty J-shaped resin blocks (Endo Training Bloc-J; Dentsply Maillefer, Ballaigues, Switzerland) were trimmed to a root-shaped form and divided into 2 groups according to the types of electric motors: WaveOne motor (WOM, Dentsply Maillefer) and X-Smart Plus motor (XSM, Dentsply Maillefer)...
April 25, 2017: Journal of Endodontics
Jonathan H Peck, David C Sing, Srinidhi Nagaraja, Deepa G Peck, Jeffrey C Lotz, Anton E Dmitriev
Cervical intervertebral body fusion devices (IBFDs) are utilized to provide stability while fusion occurs in patients with cervical pathology. For a manufacturer to market a new cervical IBFD in the United States, substantial equivalence to a cervical IBFD previously cleared by FDA must be established through the 510(k) regulatory pathway. Mechanical performance data are typically provided as part of the 510(k) process for IBFDs. We reviewed all Traditional 510(k) submissions for cervical IBFDs deemed substantially equivalent and cleared for marketing from 2007 through 2014...
March 21, 2017: Journal of Biomechanics
Mathieu Nadeau-Vallée, Peck-Yin Chin, Lydia Belarbi, Marie-Ève Brien, Sheetal Pundir, Martin H Berryer, Alexandra Beaudry-Richard, Ankush Madaan, David J Sharkey, Alexis Lupien-Meilleur, Xin Hou, Christiane Quiniou, Alexandre Beaulac, Ines Boufaied, Amarilys Boudreault, Adriana Carbonaro, Ngoc-Duc Doan, Jean-Sebastien Joyal, William D Lubell, David M Olson, Sarah A Robertson, Sylvie Girard, Sylvain Chemtob
Preterm birth (PTB) is commonly accompanied by in utero fetal inflammation, and existing tocolytic drugs do not target fetal inflammatory injury. Of the candidate proinflammatory mediators, IL-1 appears central and is sufficient to trigger fetal loss. Therefore, we elucidated the effects of antenatal IL-1 exposure on postnatal development and investigated two IL-1 receptor antagonists, the competitive inhibitor anakinra (Kineret) and a potent noncompetitive inhibitor 101.10, for efficacy in blocking IL-1 actions...
February 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
Jung-Hong Ha, Sang Won Kwak, Sung-Kyo Kim, Hyeon-Cheol Kim
OBJECTIVES: The purpose of this study was to compare the maximum screw-in forces generated during the movement of various Nickel-Titanium (NiTi) file systems. MATERIALS AND METHODS: Forty simulated canals in resin blocks were randomly divided into 4 groups for the following instruments: Mtwo size 25/0.07 (MTW, VDW GmbH), Reciproc R25 (RPR, VDW GmbH), ProTaper Universal F2 (PTU, Dentsply Maillefer), and ProTaper Next X2 (PTN, Dentsply Maillefer, n = 10). All the artificial canals were prepared to obtain a standardized lumen by using ProTaper Universal F1...
November 2016: Restorative Dentistry & Endodontics
Sandeep Prabhu, Vincent Mackin, Alex J A McLellan, Tuong Phan, Desmond McGlade, Liang-Han Ling, Kah Y Peck, Alexandr Voskoboinik, Bupesh Pathik, Chrishan J Nalliah, Geoff R Wong, Sonia M Azzopardi, Geoffrey Lee, Justin Mariani, Andrew J Taylor, Jonathan M Kalman, Peter M Kistler
INTRODUCTION: ELECTROPHYSIOLOGICAL AND HEMODYNAMIC ASSESSMENT. DORMANT-AF STUDY: The significance of adenosine induced dormant pulmonary vein (PV) conduction in atrial fibrillation (AF) ablation remains controversial. The optimal dose of adenosine to determine dormant PV conduction is yet to be systematically explored. METHODS AND RESULTS: ELECTROPHYSIOLOGICAL AND HEMODYNAMIC ASSESSMENT. DORMANT-AF STUDY: Consecutive patients undergoing index AF ablation received 3 adenosine doses (12, 18, and 24 mg) in a randomized blinded order, immediately after pulmonary vein isolation (PVI)...
January 2017: Journal of Cardiovascular Electrophysiology
Nadia Nuraniya Kamaluddin, Akiko Nakagawa-Izumi, Shota Nishizawa, Ayuko Fukunaga, Shuichi Doi, Tsuyoshi Yoshimura, Sakae Horisawa
We found that decayed wood stakes with no termite damage collected from a termite-infested field exhibited a deterrent effect against the termite Reticulitermes speratus, Kolbe, 1885. The effect was observed to be lost or reduced by drying. After identification, it was found that the decayed stakes were infected by brown rot fungus Fibroporia radiculosa (Peck) Parmasto, 1968. In a no-choice feeding test, wood blocks decayed by this fungus under laboratory condition deterred R. speratus feeding and n-hexane extract from the decayed stake and blocks induced termite mortality...
August 18, 2016: Insects
Yueming Zhai, Joseph S DuChene, Yi-Chung Wang, Jingjing Qiu, Aaron C Johnston-Peck, Bo You, Wenxiao Guo, Benedetto DiCiaccio, Kun Qian, Evan W Zhao, Frances Ooi, Dehong Hu, Dong Su, Eric A Stach, Zihua Zhu, Wei David Wei
After more than a decade, it is still unknown whether the plasmon-mediated growth of silver nanostructures can be extended to the synthesis of other noble metals, as the molecular mechanisms governing the growth process remain elusive. Herein, we demonstrate the plasmon-driven synthesis of gold nanoprisms and elucidate the details of the photochemical growth mechanism at the single-nanoparticle level. Our investigation reveals that the surfactant polyvinylpyrrolidone preferentially adsorbs along the nanoprism perimeter and serves as a photochemical relay to direct the anisotropic growth of gold nanoprisms...
August 2016: Nature Materials
Barrie Peck, Zachary T Schug, Qifeng Zhang, Beatrice Dankworth, Dylan T Jones, Elizabeth Smethurst, Rachana Patel, Susan Mason, Ming Jiang, Rebecca Saunders, Michael Howell, Richard Mitter, Bradley Spencer-Dene, Gordon Stamp, Lynn McGarry, Daniel James, Emma Shanks, Eric O Aboagye, Susan E Critchlow, Hing Y Leung, Adrian L Harris, Michael J O Wakelam, Eyal Gottlieb, Almut Schulze
BACKGROUND: Enhanced macromolecule biosynthesis is integral to growth and proliferation of cancer cells. Lipid biosynthesis has been predicted to be an essential process in cancer cells. However, it is unclear which enzymes within this pathway offer the best selectivity for cancer cells and could be suitable therapeutic targets. RESULTS: Using functional genomics, we identified stearoyl-CoA desaturase (SCD), an enzyme that controls synthesis of unsaturated fatty acids, as essential in breast and prostate cancer cells...
2016: Cancer & Metabolism
Li Zhou, Adriana Nicholson Vest, Raymond A Peck, Jonathan P Sredl, Xuechen Huang, Yaniv Bar-Cohen, Michael J Silka, Jay D Pruetz, Ramen H Chmait, Gerald E Loeb
This paper discusses the technical and safety requirements for cardiac pacing of a human fetus with heart failure and hydrops fetalis secondary to complete heart block. Engineering strategies to meet specific technical requirements were integrated into a systematic design and implementation consisting of a novel fetal micropacemaker, a percutaneous implantation system, and a sterile package that enables device storage and recharging maintenance in a clinical setting. We further analyzed observed problems on myocardial fixation and pacing lead fatigue previously reported in earlier preclinical trials...
December 2016: Medical & Biological Engineering & Computing
S Steenfeldt, B L Nielsen
Multi-tier aviary systems, where conveyor belts below the tiers remove the manure at regular intervals, are becoming more common in organic egg production. The area on the tiers can be included in the net area available to the hens (also referred to as usable area) when calculating maximum indoor stocking densities in organic systems within the EU. In this article, results on live weight, health measures and perching are reported for organic laying hens housed in a multi-tier system with permanent access to a veranda and kept at stocking densities (D) of 6, 9 and 12 hens/m2 available floor area, with concomitant increases in the number of hens per trough, drinker, perch and nest space...
September 2015: Animal: An International Journal of Animal Bioscience
Andrew R Craig, Paul J Cunningham, Timothy A Shahan
Behavioral momentum theory suggests that the relation between a discriminative-stimulus situation and reinforcers obtained in that context (i.e., the Pavlovian stimulus-reinforcer relation) governs persistence of operant behavior. Within the theory, a mass-like aspect of behavior has been shown to be a power function of predisruption reinforcement rates. Previous investigations of resistance to change in multiple schedules, however, have been restricted to examining response persistence following protracted periods of stability in reinforcer rates within a discriminative situation...
May 2015: Journal of the Experimental Analysis of Behavior
Jung-Hong Ha, Chan-Joo Lee, Sang-Won Kwak, Rashid El Abed, Dongseok Ha, Hyeon-Cheol Kim
INTRODUCTION: This study was done to develop a glide path preparation nickel-titanium rotary instrument by size optimization procedures and evaluate the properties of the prototype. METHODS: G-1 and G-2 files were tested for cyclic fatigue, torsional resistance, and screw-in force. The cyclic fatigue resistance was compared by measuring the number of cycles to failure by using a 90° curved metal canal (n = 10). The torsional resistance was evaluated at 3 levels (2, 4, and 6 mm from the file tip) by measuring the ultimate torsional load (n = 10 each level)...
June 2015: Journal of Endodontics
C A Lewis, C Brault, B Peck, K Bensaad, B Griffiths, R Mitter, P Chakravarty, P East, B Dankworth, D Alibhai, A L Harris, A Schulze
Oxygen and nutrient limitation are common features of the tumor microenvironment and are associated with cancer progression and induction of metastasis. The inefficient vascularization of tumor tissue also limits the penetration of other serum-derived factors, such as lipids and lipoproteins, which can be rate limiting for cell proliferation and survival. Here we have investigated the effect of hypoxia and serum deprivation on sterol regulatory element-binding protein (SREBP) activity and the expression of lipid metabolism genes in human glioblastoma multiforme (GBM) cancer cells...
October 1, 2015: Oncogene
Li Zhou, Adriana N Vest, Ramen H Chmait, Yaniv Bar-Cohen, Jay Pruetz, Michael Silka, Kaihui Zheng, Ray Peck, Gerald E Loeb
A miniaturized, self-contained pacemaker that could be implanted with a minimally invasive technique would dramatically improve the survival rate for fetuses that develop hydrops fetalis as a result of congenital heart block. We are currently validating a device that we developed to address this bradyarrhythmia. Preclinical studies in a fetal sheep model are underway to demonstrate that the device can be implanted via a minimally invasive approach, can mechanically withstand the harsh bodily environment, can induce effective contractions of the heart muscle with an adequate safety factor, and can successfully operate for the required device lifetime of three months using the previously-developed closed loop transcutaneous recharging system...
2014: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Janelle R Zacherl, Irina Tourkova, Claudette M St Croix, Lisa J Robinson, Octavia M Peck Palmer, Stephanie J Mihalik, Harry C Blair
Artificial trans fatty acids promote atherosclerosis by blocking macrophage clearance of cell debris. Classical fatty-acid response mechanisms include TLR4-NF-κB activation, and Erk1/2 phosphorylation, but these may not indicate long-term mechanisms. Indeed, nuclear NF-κB was increased by 60 min treatment by 30 μM of the 18 carbon trans unsaturated fatty acid elaidic acid (elaidate), the physiological cis-unsaturated fatty acid oleic acid (oleate), and the 18 or 16 carbon saturated fatty acids stearic and palmitic acid (stearate or palmitate)...
April 2015: Journal of Cellular Biochemistry
Elio Berutti, Mario Alovisi, Michele Angelo Pastorelli, Giorgio Chiandussi, Nicola Scotti, Damiano Pasqualini
INTRODUCTION: Instrument failure caused by excessive torsional stress can be controlled by creating a manual or mechanical glide path. The ProGlider single-file system (Dentsply Maillefer, Ballaigues, Switzerland) was recently introduced to perform a mechanical glide path. This study was designed to compare the effect of a glide path performed with PathFiles (Dentsply Maillefer) and ProGlider on torque, time, and pecking motion required for ProTaper Next X1 (Dentsply Maillefer) to reach the full working length in simulated root canals...
December 2014: Journal of Endodontics
Kenneth J Leising, Jared Wong, Chad M Ruprecht, Aaron P Blaisdell
Many studies investigating cue competition have focused on the blocking effect. We investigated the blocking effect with pigeons using a landmark-based spatial search task in both a touchscreen preparation (Exp. 1a) and an automated remote environmental navigation apparatus (Exp. 1b). In Phase 1, two landmarks (LMs: A and Z) appeared on separate trials as colored circles among a row of eight (touchscreen) or six (ARENA) identical response units. Subjects were rewarded for pecking at a target response unit to the right of LM A and to the left of an extraneous LM, Z...
December 2014: Learning & Behavior
Bärbel Friedrichs, Ute Neumann, Jutta Schüller, Michael J Peck
In vitro treatment of human peripheral blood neutrophils from smokers and non-smokers with an aqueous cigarette smoke (CS) extract resulted in a concentration-dependent increase in surface expression of CD11b and CD66b and a corresponding decrease of CD62L, together with a concentration-dependent release of MMP-8, MMP-9, and lactoferrin, indicating considerable activation and degranulation. However, the burst response to N-formyl-methionyl-leucyl-phenylalanine (fMLP) was unchanged in CS-stimulated neutrophils from both smokers and non-smokers...
October 2014: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Klaus H Oldach, David M Peck, Ramakrishnan M Nair, Maria Sokolova, John Harris, Paul Bogacki, Ross Ballard
BACKGROUND: The nematode Pratylenchus neglectus has a wide host range and is able to feed on the root systems of cereals, oilseeds, grain and pasture legumes. Under the Mediterranean low rainfall environments of Australia, annual Medicago pasture legumes are used in rotation with cereals to fix atmospheric nitrogen and improve soil parameters. Considerable efforts are being made in breeding programs to improve resistance and tolerance to Pratylenchus neglectus in the major crops wheat and barley, which makes it vital to develop appropriate selection tools in medics...
2014: BMC Plant Biology
Hyo-Jin Jeon, Avina Paranjpe, Jung-Hong Ha, Euiseong Kim, WooCheol Lee, Hyeon-Cheol Kim
INTRODUCTION: The purpose of this study was to evaluate the apical preparation sizes resulting from repetitive pecking motions at the working length (WL) by using reciprocating files. METHODS: Sixty simulated endodontic training blocks with a J-shaped root canal were instrumented using Reciproc R25 (VDW, Munich, Germany) or WaveOne Primary (Dentsply Maillefer, Ballaigues, Switzerland) (n = 30 each). Each group was divided into 3 subgroups based on the repetitive pecking times at the WL: 1, 2, and 4 times...
February 2014: Journal of Endodontics
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