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https://www.readbyqxmd.com/read/29045554/veliparib-with-temozolomide-or-carboplatin-paclitaxel-versus-placebo-with-carboplatin-paclitaxel-in-patients-with-brca1-2-locally-recurrent-metastatic-breast-cancer-randomized-phase-ii-study
#1
H S Han, V Diéras, M Robson, M Palácová, P K Marcom, A Jager, I Bondarenko, D Citrin, M Campone, M L Telli, S M Domchek, M Friedlander, B Kaufman, J E Garber, Y Shparyk, E Chmielowska, E H Jakobsen, V Kaklamani, W Gradishar, C K Ratajczak, C Nickner, Q Qin, J Qian, S P Shepherd, S J Isakoff, S Puhalla
Background: Homologous recombination defects in BRCA1/2-mutated tumors result in sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors, which interfere with DNA damage repair. Veliparib, a potent PARP inhibitor, enhanced the antitumor activity of platinum agents and temozolomide in early phase clinical trials. This phase II study examined the safety and efficacy of intermittent veliparib with carboplatin/paclitaxel (VCP) or temozolomide (VT) in patients with BRCA1/2-mutated breast cancer...
September 29, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045266/travel-distance-as-a-barrier-to-receipt-of-adjuvant-radiation-therapy-after-radical-prostatectomy
#2
David D Yang, Vinayak Muralidhar, Brandon A Mahal, Clair J Beard, Kent W Mouw, Neil E Martin, Peter F Orio, Martin T King, Paul L Nguyen
OBJECTIVES: Following radical prostatectomy (RP), adjuvant radiation therapy (RT) decreases biochemical recurrence and potentially improves metastasis-free and overall survival for patients with high-risk pathologic features. Since adjuvant RT typically occurs daily over several weeks, the logistical challenges of extensive traveling may be a significant barrier to its use. We examined the association between distance to treatment facility and use of adjuvant RT. MATERIALS AND METHODS: We identified 97,568 patients in the National Cancer Database diagnosed from 2004 through 2011 with cT1-4N0-xM0-x prostate cancer and found to have high-risk pathologic features (pT3-4 stage and/or positive surgical margins) at RP...
October 17, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29045251/novel-endoscopic-visualization-techniques-for-bladder-cancer-detection-a-review-of-the-contemporary-literature
#3
Andrea Mari, Mohammad Abufaraj, Killian M Gust, Shahrokh F Shariat
PURPOSE OF REVIEW: To describe the principles of photodynamic diagnosis (PDD), narrow-band imaging (NBI) and Storz Professional Image Enhancement System (SPIES) techniques for the endoscopic management of nonmuscle-invasive bladder cancer (BCa) and to report their impact on clinical practice. RECENT FINDINGS: PDD is associated with an increased sensitivity for detecting BCa specifically carcinoma in situ (CIS). Moreover, PDD has been shown to lower recurrence rate in comparison with white-light cystoscopy...
October 17, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29044862/efficacy-and-safety-of-vinorelbine-plus-cisplatin-chemotherapy-for-patients-with-recurrent-and-or-metastatic-salivary-gland-cancer-of-the-head-and-neck
#4
Min Hee Hong, Chang Gon Kim, Yoon Woo Koh, Eun Chang Choi, Jinna Kim, Sun Och Yoon, Hye Ryun Kim, Byoung Chul Cho
BACKGROUND: The purpose of this study was to investigate the efficacy and safety of vinorelbine plus cisplatin chemotherapy in patients with recurrent and/or metastatic salivary gland cancer of the head and neck. METHODS: In this single-arm phase II study, patients with recurrent and/or metastatic salivary gland cancer were treated with i.v. vinorelbine (25 mg/m(2) ) on days 1 and 8 plus cisplatin (80 mg/m(2) ) on day 1 every 3 weeks for 4 or 6 cycles. The primary endpoint was the objective response rate...
October 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/29044605/amputations-for-extremity-soft-tissue-sarcoma-in-an-era-of-limb-salvage-treatment-local-control-and-survival
#5
Marc G Stevenson, Annelie H Musters, Jan H B Geertzen, Barbara L van Leeuwen, Harald J Hoekstra, Lukas B Been
BACKGROUND: Despite multimodality limb salvage treatment (LST) for locally advanced extremity soft tissue sarcoma (ESTS), some patients still need an amputation. Indications for amputation and oncological outcome for these patients are described. METHODS: Between 1996 and 2016, all patients who underwent an amputation for ESTS were included. Patients who underwent an amputation as primary or as non-primary treatment formed Group I and II, respectively. RESULTS: Thirty-nine patients were included, 16 in Group I (41%) and 23 in Group II (59%)...
October 16, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29044578/factors-associated-with-local-recurrence-after-surgery-for-bone-metastasis-to-the-extremities
#6
Chandra Kumar Krishnan, Han-Soo Kim, Ji Yeon Yun, Hwan Seong Cho, Jong Woong Park, Ilkyu Han
BACKGROUND AND OBJECTIVES: With increasing life expectancy of patients with bone metastasis, durable surgical stabilization of bone metastasis is necessary. Local recurrence (LR) can compromise surgical stabilization and necessitate retreatment. We analyzed LR rate and factors associated with LR in patients undergoing surgery for bone metastasis. METHODS: Patients (n = 301) who underwent surgery for bone metastasis to the extremities were reviewed. Possible factors that might be associated with LR were investigated...
October 16, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29044538/laparoscopic-versus-open-surgery-for-rectal-cancer-after-neoadjuvant-chemoradiation-long-term-outcomes-of-a-propensity-score-matched-study
#7
Ramakrishnan Ayloor Seshadri, Rajaraman Swaminathan, Ayyappan Srinivasan
BACKGROUND AND OBJECTIVES: Laparoscopic resection for rectal cancer has short-term benefits when compared to open resection. The aim of this study was to compare the long-term oncological outcomes of laparoscopic and open resection for rectal cancer following neoadjuvant chemoradiation (NCRT). METHODS: In this propensity matched study, a series of 72 patients who underwent laparoscopic surgery for rectal cancer following NCRT between 2004 and 2010 (Lap group) were matched with 72 patients who underwent open surgery for rectal cancer in the same period (Open group)...
October 16, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29043525/long-term-follow-up-and-post-relapse-outcome-of-patients-with-localized-retroperitoneal-sarcoma-treated-in-the-italian-sarcoma-group-soft-tissue-sarcoma-isg-sts-protocol-0303
#8
R De Sanctis, L Giordano, C Colombo, A De Paoli, P Navarria, C Sangalli, A Buonadonna, R Sanfilippo, G Bertola, M Fiore, A Marrari, F Navarria, A Bertuzzi, P G Casali, S Basso, A Santoro, V Quagliuolo, A Gronchi
BACKGROUND: This study was designed to assess patterns of recurrence and long-term outcomes of patients undergoing surgery for localized retroperitoneal sarcoma (RPS) after neoadjuvant high dose long-infusion ifosfamide (HLI) and radiotherapy (RT). METHODS: Patients received three cycles of HLI (14 g/m(2)). RT was started in combination with II cycle up to a total dose of 50.4 Gy. Surgery was scheduled 4-6 weeks after the end of RT. The primary endpoint was relapse-free survival (RFS) after surgery...
October 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29043496/erlotinib-plus-bevacizumab-phase-ll-study-in-patients-with-advanced-non-small-cell-lung-cancer-jo25567-updated-safety-results
#9
Terufumi Kato, Takashi Seto, Makoto Nishio, Koichi Goto, Noboru Yamamoto, Isamu Okamoto, Liang Tao, Wei Yu, Tarik Khaznadar, Kosei Tajima, Masahiko Shibata, Akihiro Seki, Nobuyuki Yamamoto
INTRODUCTION: The phase II JO25567 study compared the efficacy and safety of erlotinib plus bevacizumab vs. erlotinib alone as first-line therapy for advanced epidermal growth factor receptor (EGFR) mutation-positive non-small-cell lung cancer (NSCLC). OBJECTIVE: Our objective is to provide updated analyses of safety and the assessment of manageability of specific adverse events. METHODS: Patients with stage IIIB/IV or recurrent, non-squamous, EGFR mutation-positive NSCLC were randomized to receive erlotinib plus bevacizumab or erlotinib...
October 17, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29043410/determination-of-the-absolute-oral-bioavailability-of-niraparib-by-simultaneous-administration-of-a-14-c-microtracer-and-therapeutic-dose-in-cancer-patients
#10
L van Andel, H Rosing, Z Zhang, L Hughes, V Kansra, M Sanghvi, M M Tibben, A Gebretensae, J H M Schellens, J H Beijnen
INTRODUCTION: Niraparib (Zejula™) is a poly(ADP-ribose) polymerase inhibitor recently approved by the US Food and Drug Administration for the maintenance treatment of patients with recurrent platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy. The pivotal phase III clinical trial has shown improved progression-free survival in patients receiving niraparib compared with those receiving placebo...
October 17, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29043409/margin-width-of-resected-lepidic-lung-cancer-does-not-affect-recurrence-after-sublobar-resection
#11
Youngkyu Moon, Kyo Young Lee, Jae Kil Park
BACKGROUND: A sufficient resection margin is required for the sublobar resection of lung cancers. However, the width of the resection margin may not be important in lepidic adenocarcinoma, because such tumors are non- or minimally invasive. The purpose of this study was to determine the effect of resection margin width on the outcome of patients with lepidic-dominant adenocarcinoma after sublobar resection. METHODS: This study included 133 patients with small (≤2 cm), clinical N0M0 lung cancer who underwent sublobar resection with curative intent...
October 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29042795/significant-association-of-the-exo1-rs851797-polymorphism-with-clinical-outcome-of-ovarian-cancer
#12
Tingyan Shi, Rong Jiang, Pan Wang, Yuan Xu, Sheng Yin, Xi Cheng, Rongyu Zang
BACKGROUND: Exonuclease 1 (EXO1), one of DNA mismatch repair pathway genes, functions in maintaining genomic stability and affects tumor progression. We hypothesized that genetic variations in EXO1 may predict clinical outcomes in epithelial ovarian cancer (EOC). METHODS: In this cohort study with 1,030 consecutive EOC patients, we genotyped four potentially functional polymorphisms in EXO1 by the Taqman assay and evaluated their associations with patients' survival...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29042794/comparison-of-microwave-ablation-and-hepatic-resection-for-hepatocellular-carcinoma-a-meta-analysis
#13
REVIEW
Manka Zhang, Huimin Ma, Jian Zhang, Lingling He, Xiaohui Ye, Xin Li
BACKGROUND AND AIMS: Hepatic resection (HRN) and microwave ablation (MWA) have significant advantages in treating hepatocellular carcinoma; however, it remains unclear which way produces better outcomes. This meta-analysis of cohort studies compared the treatments in terms of effectiveness and safety. METHODS: Six electronic databases (PubMed, Medline, EMBASE, Web of Science, EBSCO, and The Cochrane Library) were retrieved for studies comparing MWA and HRN. The meta-analysis was conducted based on statement of preferred reporting items for systematic reviews and meta-analyses...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29041898/societal-preferences-for-adjuvant-melanoma-health-states-uk-and-australia
#14
Mark R Middleton, Michael B Atkins, Kaitlan Amos, Peter Feng Wang, Srividya Kotapati, Javier Sabater, Kathleen Beusterien
BACKGROUND: No studies have measured preference-based utility weights for specific toxicities and outcomes associated with approved and investigational adjuvant treatments for patients with resected high-risk melanoma. METHODS: A cross-sectional study was conducted in the United Kingdom and Australia to obtain utilities for 14 adjuvant melanoma health states. One-on-one interviews were conducted using standard gamble; utility weights range from 0.0, dead, to 1.0, full health...
October 17, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29040918/tumor-cryoablation-in-combination-with-natural-killer-cells-therapy-and-herceptin-in-patients-with-her2-overexpressing-recurrent-breast-cancer
#15
Shuzhen Liang, Lizhi Niu, Kecheng Xu, Xiaohua Wang, Yingqing Liang, Mingjie Zhang, Jibing Chen, Mao Lin
In this study, we investigated the clinical benefits of a combination of tumor cryoablation with natural killer (NK) cells therapy and Herceptin for human epidermal growth factor (HER) 2-overexpressing recurrent breast cancer. From May 2015 to May 2016, 48 patients who met the enrollment criteria were assigned to three groups (n=16): cryoablation group (group I), cryoablation-NK cells therapy group (group II) and cryoablation-NK cells therapy-Herceptin group (group III). Safety and short-term effects were evaluated...
October 13, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29039987/a-propensity-score-based-analysis-of-laparoscopic-liver-resection-for-liver-malignancies-in-elderly-patients
#16
Amr Badawy, Satoru Seo, Rei Toda, Hiroaki Fuji, Ken Fukumitsu, Takamichi Ishii, Kojiro Taura, Toshimi Kaido, Shinji Uemoto
PURPOSE: Laparoscopic liver resection is safe, feasible and associated with less blood loss, shorter hospital stays and fewer postoperative complications in the working age patients with malignant liver tumors. However, it is still unclear if the elderly patients with malignant liver tumors would also benefit from that approach as the younger patients. So, the aim of the study was to compare the clinical outcomes of laparoscopic versus open liver resection for malignant liver tumors in elderly patients...
October 17, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29039079/a-long-term-survivor-of-hilar-cholangiocarcinoma-with-resection-of-recurrent-peritoneal-dissemination-after-r0-surgery-a-case-report
#17
Tatsunori Miyata, Hirohisa Okabe, Akira Chikamoto, Takanobu Yamao, Naoki Umezaki, Masayo Tsukamoto, Yuki Kitano, Kota Arima, Shigeki Nakagawa, Katsunori Imai, Daisuke Hashimoto, Yo-Ichi Yamashita, Hideo Baba
BACKGROUND: Although hilar cholangiocarcinoma (HCCA) has a very poor prognosis, there are cases in which long-term survival is rarely obtained by multidisciplinary treatment. CASE PRESENTATION: A 61-year-old man diagnosed with HCCA was referred to our hospital. We performed an extended left hemi-hepatectomy and caudate lobectomy with extrahepatic bile duct resection. The tumor stage was T2aN0M0, stage II, based on the TNM classification, seventh edition. R0 resection was successfully performed...
October 16, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29038963/lymph-node-density-as-a-prognostic-predictor-in-patients-with-betel-nut-related-oral-squamous-cell-carcinoma
#18
Wei-Chin Chang, Chun-Shu Lin, Cheng-Yu Yang, Chih-Kung Lin, Yuan-Wu Chen
OBJECTIVES: Lymph node metastasis in oral squamous cell carcinoma (OSCC) is a poor prognostic factor. The histopathologic stage (e.g., pN) is used to evaluate the severity of lymph node metastasis; however, the current staging system insufficiently predicts survival and recurrence. We investigated clinical outcomes and lymph node density (LND) in betel nut-chewing individuals. MATERIAL AND METHODS: We retrospectively analyzed 389 betel nut-exposed patients with primary OSCC who underwent surgical resection in 2002-2015...
October 17, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29038848/ca19-9-kinetics-during-systemic-chemotherapy-in-patients-with-advanced-or-recurrent-biliary-tract-cancer
#19
Naminatsu Takahara, Yousuke Nakai, Hiroyuki Isayama, Takashi Sasaki, Kei Saito, Kensaku Noguchi, Tatsunori Suzuki, Tomoka Nakamura, Tatsuya Sato, Kazunaga Ishigaki, Ryunosuke Hakuta, Tsuyoshi Takeda, Rie Uchino, Suguru Mizuno, Hirofumi Kogure, Minoru Tada, Kazuhiko Koike
PURPOSE: The role of carbohydrate antigen 19-9 (CA19-9) kinetics in patients with biliary tract cancer (BTC) receiving chemotherapy remains to be elucidated. METHODS: A total of 185 advanced or recurrent BTC patients receiving a first line chemotherapy between January 2006 and March 2016, were retrospectively studied. Serum CA19-9 was measured at baseline and after two cycles of chemotherapy, and patients were categorized based on CA19-9 response: CA19-9 decrease group (≥ 30% decrease), stable group (< 30% decrease and < 20% increase) and increase group (≥ 20% increase)...
October 16, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29038762/clinical-outcomes-of-residual%C3%A2-or%C3%A2-recurrent-nasopharyngeal-carcinoma-treated-with-endoscopic-nasopharyngectomy-plus-chemoradiotherapy-or-with-chemoradiotherapy-alone-a-retrospective-study
#20
Jingjin Weng, Jiazhang Wei, Jinyuan Si, Yangda Qin, Min Li, Fei Liu, Yongfeng Si, Jiping Su
BACKGROUND: Local residual and recurrent nasopharyngeal carcinoma (NPC) generally shows treatment failure after standard radiotherapy with or without concurrent chemotherapy. Whether endoscopic nasopharyngectomy might provide an additional therapeutic advantage remains controversial. Therefore, we retrospectively compared the clinical prognoses of patients with residual or recurrent NPC treated with endoscopic nasopharyngectomy combined with chemoradiotherapy (CRT) with those of patients treated with CRT alone...
2017: PeerJ
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