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https://www.readbyqxmd.com/read/29929138/prothrombotic-mechanisms-in-patients-with-congenital-p-cys89tyr-mutation-in-cd59
#1
Adi Tabib, Issam Hindi, Netanel Karbian, Orly Zelig, Batla Falach, Dror Mevorach
BACKGROUND: Thrombosis is the prognostic factor with the greatest effect on survival in patients with paroxysmal nocturnal hemoglobinuria (PNH), who lack dozens of membrane surface proteins. We recently described a primary homozygous Cys89Tyr congenital nonfunctioning CD59 in humans with clinical manifestation in infancy, associated with chronic hemolysis, recurrent strokes, and relapsing peripheral demyelinating neuropathy. Here we investigated hypercoagulability mechanisms characterizing the syndrome...
June 11, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29929092/adjuvant-chemotherapy-and-postoperative-radiotherapy-in-high-risk-soft-tissue-sarcoma-patients-defined-by-biological-risk-factors-a-scandinavian-sarcoma-group-study-ssg-xx
#2
Kirsten Sundby Hall, Øyvind S Bruland, Bodil Bjerkehagen, Olga Zaikova, Jacob Engellau, Oskar Hagberg, Lina Hansson, Hans Hagberg, Marie Ahlström, Heidi Knobel, Karin Papworth, Maja Zemmler, Dorota Goplen, Henrik C F Bauer, Mikael Eriksson
PURPOSE: To investigate the outcome following adjuvant doxorubicin and ifosfamide in a prospective non-randomised study based on a soft tissue sarcoma (STS) patient subgroup defined by specific morphological characteristics previously shown to be at a high-risk of metastatic relapse. The expected 5-year cumulative incidence of metastases in patients with this risk profile has previously been reported to be about 50% without adjuvant chemotherapy. METHODS: High-risk STS was defined as high-grade morphology (according to the Fédération Nationale des Centres de Lutte Contre le Cancer [FNCLCC] grade II-III) and either vascular invasion or at least two of the following criteria: tumour size ≥8...
June 18, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29927628/survival-outcomes-and-patterns-of-failure-after-d2-dissection-and-adjuvant-chemoradiotherapy-for-locally-advanced-gastric-cancer-a-retrospective-study
#3
Wang Yang, Ran Hu, Guichao Li, Menglong Zhou, Yan Wang, Lijun Shen, Liping Liang, Zhen Zhang
OBJECTIVE: The goal of the study was to analyze the incidence and patterns of failure in patients with gastric cancer who received D2 dissection and adjuvant chemoradiotherapy (CRT). METHODS: From January 2004 to October 2015, 324 patients with gastric cancer who underwent radical D2 resection followed by postoperative CRT were enrolled. Clinicopathological characteristics and patterns of failure were retrospectively reviewed to identify factors associated with survival and recurrence...
June 21, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29927331/low-versus-high-risk-rectal-cancer-based-on-mri-features-outcomes-in-patients-treated-without-neoadjuvant-chemoradiotherapy
#4
Xiao-Xuan Jia, Yi Wang, Jin Cheng, Xun Yao, Mu-Jun Yin, Jing Zhou, Ying-Jiang Ye
OBJECTIVE: The objective of this study was to compare the prognoses of patients with low- and high-risk rectal cancer detected by MRI who were treated without neoadjuvant chemoradiotherapy (NCRT) and to determine independent risk factors. MATERIALS AND METHODS: This retrospective study included 185 patients with pathologically proven rectal adenocarcinoma who were treated without NCRT. Cancer was defined as high risk if one or more of the following factors were present: extramural depth of tumor invasion greater than 5 mm or stage T4a or T4b for tumor in the mid or high rectum; involvement of intersphincteric space, levators, or adjacent organs for tumor in the low rectum; extramural venous invasion (EMVI); or circumferential resection margin (CRM) involvement...
June 21, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29926900/breast-conserving-surgery-followed-by-whole-breast-irradiation-offers-survival-benefits-over-mastectomy-without-irradiation
#5
J de Boniface, J Frisell, L Bergkvist, Y Andersson
BACKGROUND: The prognostic equivalence between mastectomy and breast-conserving surgery (BCS) followed by radiotherapy was shown in pivotal trials conducted decades ago. Since then, detection and treatment of breast cancer have improved substantially and recent retrospective analyses point towards a survival benefit for less extensive breast surgery. Evidence for the association of such survival data with locoregional recurrence rates is largely lacking. METHODS: The Swedish Multicentre Cohort Study prospectively included clinically node-negative patients with breast cancer who had planned sentinel node biopsy between 2000 and 2004...
June 21, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29926523/a-genome-wide-analysis-of-long-noncoding-rna-profile-identifies-differentially-expressed-lncrnas-associated-with-esophageal-cancer
#6
Wenjia Liu, Yiyang Zhang, Min Chen, Liangliang Shi, Lei Xu, Xiaoping Zou
Esophageal cancer is one of the most common cancers and a leading cause of cancer-related death worldwide. However, the mechanism of esophageal cancer pathogenesis remains poorly understood. Long noncoding RNAs (lncRNAs) dysregulation have been reported to involve in various human cancers, which highlights the potential of lncRNAs used as novel biomarkers for cancer diagnosis. Although more efforts have been made to identify novel lncRNAs signature in esophageal cancer, the expression pattern, prognostic value, and biological function of most lncRNAs in esophageal cancer still need to be systematically investigated...
June 21, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29926241/circulating-tumor-cell-phenotype-indicates-poor-survival-and-recurrence-after-surgery-for-hepatocellular-carcinoma
#7
Huohui Ou, Yu Huang, Leyang Xiang, Zhanjun Chen, Yinghao Fang, Yixiong Lin, Zhonglin Cui, Sheng Yu, Xianghong Li, Dinghua Yang
BACKGROUND: Circulating tumors cells (CTCs) may be a promising prognostic marker for patients with malignant tumors. However, there are few reports regarding its value for hepatocellular carcinoma (HCC) patients. AIMS: To investigate CTCs with epithelial and mesenchymal phenotypes as a potential prognostic biomarker for HCC patients. METHODS: Peripheral blood samples were obtained from 165 HCC patients before radical surgery. CTCs were isolated via the CanPatrol CTC enrichment technique and classified using epithelial-mesenchymal transition (EMT) markers...
June 21, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29925382/a-prospective-study-on-the-changes-and-clinical-significance-of-pre-operative-and-post-operative-circulating-tumor-cells-in-resectable-gastric-cancer
#8
Qiyue Zhang, Fei Shan, Ziyu Li, Jing Gao, Yilin Li, Lin Shen, Jiafu Ji, Ming Lu
BACKGROUND: Circulating tumor cells (CTCs) have been suggested as potential prognostic indicators for multiple tumors, including gastric cancer; however, pre- and post-operative CTC changes in resectable gastric cancer and possible correlations to post-operative recurrence have not been evaluated. METHODS: Subjects (n = 93) with resectable gastric cancer were prospectively reviewed from July 2013 to December 2014 at Peking University Cancer Hospital. The proportion of CTCs were evaluated before (n = 93) and after (n = 63) radical operation using a standardized CellSearch system...
June 20, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29925345/induction-therapy-with-paclitaxel-and-bevacizumab-followed-by-switch-maintenance-therapy-with-eribulin-in-japanese-patients-with-her2-negative-metastatic-breast-cancer-a-multicenter-collaborative-open-label-phase-ii-clinical-study-for-the-sbccsg-35-investigators
#9
Kenichi Inoue, Jun Ninomiya, Tsuyoshi Saito, Kei Kimizuka, Masafumi Kurosumi
BACKGROUND: To examine the efficacy and safety of induction therapy with paclitaxel and bevacizumab followed by switch maintenance therapy with eribulin (ISMT) in Japanese patients with HER2-negative metastatic breast cancer (MBC). METHODS: Patients, who had previously undergone a maximum of 2 regimens of chemotherapy, received 3 cycles of induction therapy with paclitaxel (90 mg/m2 intravenously on days 1, 8, and 15 followed by 1-week drug holiday) and bevacizumab (10 mg/kg intravenously after the completion of paclitaxel administration on days 1 and 15)...
June 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29924031/unexpected-and-durable-response-with-regorafenib-in-a-metastatic-colorectal-cancer-patient-without-kdr-mutation-a-case-report
#10
Gerardo Rosati, Nunzio Del Gaudio, Enrico Scarano, Rosa Anna Cifarelli, Lucia Altucci, Domenico Bilancia
RATIONALE: Regorafenib is an oral multikinase inhibitor and is approved as salvage therapy in the standard treatment of advanced colorectal cancer (CRC). Due to its limited efficacy, toxicity profile, and cost, it is necessary to identify those patients who may have the most benefit from regorafenib. In a previous case report, kinase insert domain receptor (KDR) mutation has been associated with exceptional clinical response (CR) in an elderly patient treated with a low dose of regorafenib; thus, it was hypothesized that it could represent a new predictive marker of drug response...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923998/clinical-study-on-postoperative-triple-negative-breast-cancer-with-chinese-medicine-study-protocol-for-an-observational-cohort-trial
#11
Jiajing Chen, Yuenong Qin, Chenping Sun, Wei Hao, Shuai Zhang, Yi Wang, Juan Chen, Lixin Chen, Yiying Ruan, Sheng Liu
BACKGROUND: Breast cancer (BC) poses a tremendous threat to the health of women worldwide, especially triple-negative breast cancers (TNBCs). Currently, the curative effect of traditional Chinese medicine (TCM) has been recognized in more and more people worldwide; however, the specific effect has not been systematically evaluated. The purpose of this cohort study is to evaluate the clinical effects of TCM syndrome differentiation on recurrence and metastasis rate, survival rate, and the quality of life in patients with TNBC...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923984/clinicopathological-and-prognostic-significance-of-pd-l1-expression-in-sarcoma-a-systematic-review-and-meta-analysis
#12
Chuanxi Zheng, Wei You, Peng Wan, Xiaochun Jiang, Jinquan Chen, Yuchen Zheng, Wei Li, Jifeng Tan, Shiquan Zhang
Programmed cell death-ligands 1 (PD-L1) is a key immune checkpoint protein and a promising therapeutic target for malignancy tumor immunotherapy. The prognostic value of PD-L1 in patients with bone and soft tissue sarcoma remains controversial. Therefore, this meta-analysis is conducted to evaluate the associations of PD-L1 expression with overall survival (OS), progression-free survival (PFS), and clinicopathological characteristics of sarcomaA comprehensive literature search of PubMed, Web of Science, Embase, and Cochrane Library was conducted for relevant studies...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923441/percutaneous-thermal-ablation-of-hepatocellular-carcinomas-located-in-the-hepatic-dome-using-artificial-carbon-dioxide-pneumothorax-retrospective-evaluation-of-safety-and-efficacy
#13
Margaux Hermida, Christophe Cassinotto, Lauranne Piron, Eric Assenat, Georges-Philippe Pageaux, Laure Escal, Marie-Ange Pierredon-Foulongne, Daniel Verzilli, Samir Jaber, Boris Guiu
INTRODUCTION: The targeting of hepatocellular carcinomas (HCC) in the hepatic dome can be challenging during percutaneous thermal ablation (PTA). The aims of this study were (1) to evaluate the safety and efficacy of PTA of HCC in the hepatic dome that cannot be visualized under US, using artificial CO2 pneumothorax and CT-guidance and (2) to compare the results with US-visible HCC located in the liver dome treated under US-guidance. MATERIALS: Over a 32-month period, 56 HCC located in the hepatic dome were extracted from a prospectively maintained database...
June 20, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29923329/identification-of-differential-expressed-lncrnas-in-human-thyroid-cancer-by-a-genome-wide-analyses
#14
Wei Lu, Yongcan Xu, Jiewei Xu, Zhong Wang, Guochao Ye
Recently, a growing number of evidence has revealed that long noncoding RNAs (lncRNAs) act as key regulators in various cellular biologic processes, and dysregulation of lncRNAs involves in tumorigenesis and cancer progression. However, the expression pattern, clinical relevance, and biologic function of most lncRNAs in human thyroid cancer remain unclear. To identify more thyroid-cancer-associated lncRNAs, we analyzed the expression profile of lncRNAs in thyroid cancer tissues and adjacent normal or non-tumor tissues using RNA sequencing data and gene microarray data from The Cancer Genome Atlas and Gene Expression Omnibus...
June 20, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29922708/poorly-differentiated-ovarian-sertoli-leydig-cell-tumor-with-heterologous-rhabdomyosarcoma-and-glandular-elements-diagnosis-and-management-of-a-rare-neoplasm
#15
Charanjeet Singh, Sarfraz Ahmad, Fouad M Hajjar, Robert W Holloway
Ovarian Sertoli-Leydig cell tumors (SLCT) represent <2% of primary ovarian tumors, which range from benign to malignant; majority of the latter are low-grade. We present the case of a 12-year-old pre-pubertal female with poorly differentiated SLCT and heterologous rhabdomyosarcoma (FIGO stage-IA). She presented with worsening abdominal pain, pelvic mass, and elevated pre-operative serum Alpha-fetoprotein (AFP, 77.1 ng/mL). She underwent right salpingo-oophorectomy, omentectomy, and lymphadenectomy. The high-risk histology warranted 4-cycles of adjuvant BEP chemotherapy...
August 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29921891/management-of-low-and-intermediate-risk-adult-rhabdomyosarcoma-a-pooled-survival-analysis-of-553-patients
#16
Maha A T Elsebaie, Mohamed Amgad, Ahmed Elkashash, Ahmed Saber Elgebaly, Gehad Gamal E L Ashal, Emad Shash, Zeinab Elsayed
This is the second-largest retrospective analysis addressing the controversy of whether adult rhabdomyosarcoma (RMS) should be treated with chemotherapy regimens adopted from pediatric RMS protocols or adult soft-tissue sarcoma protocols. A comprehensive database search identified 553 adults with primary non-metastatic RMS. Increasing age, intermediate-risk disease, no chemotherapy use, anthacycline-based and poor chemotherapy response were significant predictors of poor overall and progression-free survival...
June 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29921730/prognostic-value-of-methylator-phenotype-in-stage-iii-colon-cancer-treated-with-oxaliplatin-based-adjuvant-chemotherapy
#17
Claire Gallois, Julien Taieb, Delphine Le Corre, Karine Le Malicot, Josep Tabernero, Claire Mulot, Jean-Francois Seitz, Thomas Aparicio, Gunnar Folprecht, Côme Lepage, Enrico Mini, Jean-Luc Van Laethem, Jean-Francois Emile, Pierre Laurent-Puig
PURPOSE: There are conflicting results concerning the prognostic value of the CpG island methylator phenotype (CIMP) in non-metastatic colon cancer (CC) patients. We studied this phenotype in stage III CC characterized for mismatch repair (MMR), RAS and BRAF status and treated with adjuvant FOLFOX-based regimen. EXPERIMENTAL DESIGN: Tumor samples of 1907 patients enrolled in the PETACC-8 adjuvant phase 3 trial were analyzed. The method used was methylation-specific PCR where CIMP+ status was defined by methylation of at least three of the five following genes: IGF2, CACNA1G, NEUROG1, SOCS1, and RUNX3...
June 19, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29921512/a-phase-ii-evaluation-of-sunitinib-in-the-treatment-of-persistent-or-recurrent-clear-cell-ovarian-carcinoma-an-nrg-oncology-gynecologic-oncology-group-study-gog-254
#18
John K Chan, William Brady, Bradley J Monk, Jubilee Brown, Mark S Shahin, Peter G Rose, Jae-Hoon Kim, Angeles Alvarez Secord, Joan L Walker, David M Gershenson
OBJECTIVES: To determine the efficacy and tolerability of sunitinib in recurrent or persistent clear cell ovarian cancer patients. METHODS: All patients had one or two prior regimens with measurable disease. Tumors were at least 50% clear cell histomorphology and negative for WT-1 antigen and estrogen receptor expression by immunohistochemistry. Sunitinib 50 mg per day for 4 weeks was administered in repeated 6-week cycles until disease progression or prohibitive toxicity...
June 16, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29921174/the-prognostic-impact-of-tumor-size-in-papillary-thyroid-carcinoma-is-modified-by-age
#19
Bryan Minh Tran, David James Roshan, Earl Abraham, Laura Y Wang, Natalia Garibotto, James Wykes, Peter Campbell, Ardalan Ebrahimi
BACKGROUND: Although the importance of tumor size in papillary thyroid cancer (PTC) is well established, there is no research to investigate whether age modifies the impact of tumor size, and conflicting evidence regarding optimal size thresholds for prognostic discrimination. We aimed to verify that tumor size is an independent prognostic factor in PTC, to investigate the impact of patient age, and to identify optimal size cut-offs for risk stratification using objective measures of model performance...
June 19, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29920729/long-term-follow-up-of-a-large-prospective-cohort-of-patients-with-non-functioning-pituitary-adenomas-the-outcome-of-a-conservative-management-policy
#20
Miles J Levy, Iain J Robertson, Naima Khalk, Sabrina Vitello, Narendra Reddy, Ragini Bhake, Trevor A Howlett
OBJECTIVE: To assess the clinical outcome of a strategy of conservative monitoring of patients with non-functioning pituitary adenomas (NFPA) after pituitary surgery and in patients without surgery. DESIGN: Retrospective study of outcomes, using a clinical information system. PATIENTS: An unselected, clinical series of patients seen in a single centre between 1989 and 2015. MEASUREMENTS: Review of clinical information system data to obtain details and dates of surgery, radiotherapy, pituitary imaging and outcomes...
June 19, 2018: Clinical Endocrinology
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