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transplant heart

Sarah M Eickmeyer, Kim D Barker, Anjum Sayyad, Leslie Rydberg
As an increasing number of patients with advanced heart failure are receiving a Left Ventricular Assist Device (LVAD) as either destination therapy or bridge to transplantation, there is increasing attention on functional outcomes and quality of life after LVAD implantation. Rehabilitation providers in the acute inpatient rehabilitation setting increasingly will treat patients with LVAD and should understand the exercise physiology, medical management, rehabilitation considerations, and outcomes after rehabilitation for patients with LVAD...
June 18, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
Naritaka Kimura
Congenital heart disease (CHD) is the most common birth defect, affecting 1 in 100 babies. Among CHDs, single ventricle (SV) physiologies, such as hypoplastic left heart syndrome and tricuspid atresia, are particularly severe conditions that require multiple palliative surgeries, including the Fontan procedure. Although the management strategies for SV patients have markedly improved, the prevalence of ventricular dysfunction continues to increase over time, especially after the Fontan procedure. At present, the final treatment for SV patients who develop heart failure is heart transplantation; however, transplantation is difficult to achieve because of severe donor shortages...
June 19, 2018: Keio Journal of Medicine
Christian Rojas-Contreras, Gabriel De la Cruz-Ku, Stalin Vilcarromero, Ruben Villacaqui Ayllon, Bryan Valcarcel-Valdivia
Cytomegalovirus infection after a heart transplant is a recurrent medical condition. Its frequency increases when the donors are serum-positive, and the recipients are serum-negative to this virus. In the pediatric population, the infection only develops in a small percentage and the patients rarely present resistance to conventional treatment with ganciclovir and valganciclovir. We presented the first report of a pediatric case of the cytomegalovirus infection resistant to ganciclovir and valganciclovir after a heart transplant in a Peruvian public hospital with an unusual presentation...
January 2018: Revista Peruana de Medicina Experimental y Salud Pública
Hyae-Jin Kim, Hyeon-Jeong Lee, Eunsoo Kim, Jihwan Yun
RATIONALE: Intrapleural hyperthermic chemotherapy (IPHC) is the preferred method to locally treat lung cancer with pleural seeding. Anesthetic management during IPHC is a very challenging task for the anesthesiologist because of the hemodynamic instability associated with the procedure; however, there is no report on anesthetic considerations during the IPHC procedure. PATIENT CONCERNS: Three patients who diagnosed lung cancer with pleural invasion scheduled for IPHC were reported in this case series...
June 2018: Medicine (Baltimore)
Ana M Palmar-Santos, Azucena Pedraz-Marcos, Juan Zarco-Colón, Milagros Ramasco-Gutiérrez, Eva García-Perea, Monserrat Pulido-Fuentes
BACKGROUND: The technological advances of medicine, and specifically the techniques of organ transplants, have allowed crossing the border of life and death. This is especially relevant in the case of heart transplant, since its symbolism requires a redefinition not only of these traditional concepts, but also of the body or of one's own identity. AIMS: To explore the experiences of patients after receiving a heart from a donor. METHODS: A phenomenological qualitative approach, through Merleau Ponty and Levinas perspectives, was conducted to capture the subjective experiences of heart transplant patients...
June 1, 2018: European Journal of Cardiovascular Nursing
Sarbroop Dhillon, Elizabeth McKinnon, Jeremy Wrobel, Melanie Lavender, Sharon Lawrence, Eli Gabbay, Michael Musk
BACKGROUND: The Western Australian lung transplant program commenced in 2004 to serve the growing demand of patients with end-stage lung disease. AIM: This report summarises our eleven-year experience in lung transplantation. METHODS: Data on 115 consecutive patients and their respective donors transplanted between 2004 and 2015 was collected. Kaplan-Meier method was used to estimate survival. Cox regression was used to analyse impact of donor and recipient characteristics on survival...
June 19, 2018: Internal Medicine Journal
Ramazan Kargin, Mehmet Yunus Emiroglu, Mert Evlice, Mehmet Celik, Aybala Erek Toprak, Anil Avci, Mehmet Ayturk, Seyhmus Kulahcioglu, Mustafa Bulut, Mustafa Caliskan
BACKGROUND: The aim of this study was to explore the role of oxidative stress index (OSI), myeloperoxidase (MPO), and catalase (CAT) activity in cardiac allograft vasculopathy (CAV) in heart transplant recipients (HTRs). METHODS: The study enrolled a median age of 41 ± 9 years 47 recipients. The HTx patients were divided into two groups based on the presence CAV as follows: CAV(+) and CAV(-) group. Also, CAV(+) group were divided into two groups as mild/moderate to severe CAV...
June 20, 2018: Clinical Transplantation
Michael Goldfarb, Lawrence S Czer, Lee D Lam, Jaime Moriguchi, Francisco A Arabia, Oksana Volod
Acquired von Willebrand syndrome (VWS) due to loss of high-molecular-weight multimers (HMWMs) has been reported with longer term mechanical devices and is associated with mucosal bleeding, a primary hemostasis type of bleeding. However, little is known whether a similar defect occurs in patients with short-term mechanical circulatory support (STMCS) devices. We reviewed von Willebrand factor (VWF) profiles in patients with STMCS devices who underwent VWS workup from December 2015 to March 2017 at an academic quaternary care hospital...
June 2018: Journal of Extra-corporeal Technology
Changchen Xiao, Kan Wang, Yinchuan Xu, Hengxun Hu, Na Zhang, Yingchao Wang, Zhiwei Zhong, Jing Zhao, Qingju Li, Dan Zhu, Changle Ke, Shuhan Zhong, Xianpeng Wu, Hong Yu, Wei Zhu, Jinghai Chen, Jianyi Zhang, Jian'an Wang, Xinyang Hu
<u>Rationale:</u> Autophagy can preserve cell viability under conditions of mild ischemic stress by degrading damaged organelles for ATP production, but under conditions of severe ischemia, it can promote cell death and worsen cardiac performance. Mesenchymal stem cells (MSCs) are cardioprotective when tested in animal models of myocardial infarction (MI), but whether these benefits occur through the regulation of autophagy is unknown. <u>Objective:</u> To determine whether transplanted MSCs reduce the rate of autophagic degradation (autophagic flux) in infarcted hearts and if so, to characterize the mechanisms involved...
June 19, 2018: Circulation Research
Steven Morris
Currently there are more than 2,000 children on the transplant waiting list-and more than 100,000 Americans nationwide-awaiting a matching organ. Most children aged one through 10 are awaiting a kidney, liver, or heart. As with any transplant, there are two ways to find an organ-someone can donate or someone can die. Unfortunately, the supply falls far short of the demand, leaving people to die every day waiting for a second chance at life. Scientific and medical experts, however, continue to develop promising technology like 3D bioprinting that could save thousands of lives without the need of a donor...
June 19, 2018: Birth Defects Research
Sunhye Shin, Jung-Won Choi, Soyeon Lim, Seahyoung Lee, Eun-Young Jun, Hyun-Min Sun, Il-Kwon Kim, Hoon-Bum Lee, Sang Woo Kim, Ki-Chul Hwang
Adipose-derived stromal vascular fractions (SVFs) are a heterogeneous collection of cells, and their regenerative modality has been applied in various animal experiments and clinical trials. Despite the attractive advantages of SVFs in clinical interventions, the recent status of clinical studies involving the application of SVFs in many diseases has not been fully evaluated. Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a variety of cell types despite their low numbers in heart tissue...
June 19, 2018: Cell Biochemistry and Function
Qiuheng Zhang, Michelle Hickey, Diana Drogalis-Kim, Ying Zheng, David Gjertson, Martin Cadeiras, Tam Khuu, Arnold S Baas, Eugene C Depasquale, Nancy J Halnon, Gregory Perens, Juan Alejos, Daniel Cruz, Nsair Ali, Richard Shemin, Murray Kwon, Michael C Fishbein, Abbas Ardehali, Mario Deng, Elaine F Reed
BACKGROUND: Donor specific HLA antibodies (DSA) are associated with increased rates of rejection and of graft failure in cardiac transplantation. The goal of this study was to determine the association of preformed and posttransplant development of newly detected DSA (ndDSA) with antibody mediated rejection (AMR) and characterize the clinical relevance of complement activating DSA in heart allograft recipients. METHODS: The study included 128 adult and 48 pediatric heart transplant patients transplanted between 2010 to 2013...
June 18, 2018: Transplantation
Anna Bredfelt, Göran Rådegran, Roger Hesselstrand, Håkan Arheden, Ellen Ostenfeld
AIMS: Pre-capillary pulmonary hypertension (PHpre-cap ) has a poor prognosis, especially when caused by pulmonary arterial hypertension (PAH) associated with systemic sclerosis (SSc-PAH). Whether cardiac magnetic resonance (CMR)-based quantification of atrial volumes in PHpre-cap is beneficial in risk assessment is unknown. The aims were to investigate if (i) atrial volumes using CMR are associated with death or lung transplantation in PHpre-cap , (ii) atrial volumes differ among four unmatched major PHpre-cap subgroups, and (iii) atrial volumes differ between SSc-PAH and idiopathic/familial PAH (IPAH/FPAH) when matched for pulmonary vascular resistance (PVR)...
June 19, 2018: ESC Heart Failure
Tambi Jarmi, Nirav Patel, Sadaf Aslam, George Makdisi, Elias Doumit, Rahul Mhaskar, Branko Miladinovic, Mark Weston
BACKGROUND Induction immunosuppression is used in transplantation to prevent early acute rejection. The survival benefit of rabbit anti-thymocyte globulin (rATG) induction has not been established yet. We sought to determine the role of rATG in preventing rejection and improving overall survival. MATERIAL AND METHODS A retrospective cohort study was conducted from 2005 to 2009 and data of consecutive 268 heart transplant recipients were reviewed. RESULTS The data of 144 patients who received induction with rATG were compared to 124 patients who did not...
June 19, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
Chanel F Whittaker, Margaret A Miklich, Roshni S Patel, Jeffrey C Fink
Ensuring patient safety is a priority of medical care because iatrogenic injury has been a primary concern. Medications are an important source of medical errors, and kidney disease is a thoroughfare of factors threatening safe administration of medicines. Principal among these is reduced kidney function because almost half of all medications used are eliminated via the kidney. Additionally, kidney patients often suffer from multimorbidity, including diabetes, hypertension, and heart failure, with a range of prescribers who often do not coordinate treatments...
June 18, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Wenya Ma, Fang He, Fengzhi Ding, Lai Zhang, Qi Huang, Chongwei Bi, Xiuxiu Wang, Bingjie Hua, Fan Yang, Ye Yuan, Zhenbo Han, Mengyu Jin, Tianyi Liu, Ying Yu, Benzhi Cai, Yanjie Lu, Zhimin Du
BACKGROUND/AIMS: Melatonin possesses many biological activities such as antioxidant and anti-aging. Cardiac progenitor cells (CPCs) have emerged as a promising therapeutic strategy for myocardial infarction (MI). However, the low survival of transplanted CPCs in infarcted myocardium limits the successful use in treating MI. In the present study, we aimed to investigate if melatonin protects against oxidative stress-induced CPCs damage and enhances its therapeutic efficacy for MI. METHODS: TUNEL assay and EdU assay were used to detect the effects of melatonin and miR-98 on H2O2-induced apoptosis and proliferation...
June 15, 2018: Cellular Physiology and Biochemistry
Petra Lavríková, Peter Sečník, Zdenek Kubíček, Antonín Jabor, Lenka Hošková, Janka Franeková
The aim of the study was to investigate the relationship between tacrolimus (TAC) immunosuppressive treatment and serum concentrations of immunoglobulin heavy/light chain pairs (sHLC) and free light chains (sFLC) in patients after heart transplantation (HTX) and to use these biomarkers to predict the risk of infection in these patients. A total of 88 patients with an immunosuppressive regimen involving tacrolimus who underwent HTX were analyzed over 24 months of follow-up. sFLC and sHLC levels were determined before and at three time points after HTX...
June 15, 2018: Transplant Immunology
Shengwen Yang, Zhimin Liu, Shangyu Liu, Ligang Ding, Keping Chen, Wei Hua, Shu Zhang
BACKGROUND: Serum concentration of big endothelin-1 (ET-1) has prognostic significance in heart failure. However, its prognostic value in cardiac resynchronization therapy (CRT) recipients has not been well-characterized. METHODS: A cohort of 367 consecutive patients who received CRT between January 2010 and December 2015 were enrolled, and categorized into three groups according to baseline big ET-1 tertiles: big ET-1 ≤ 0.34 pmol/L (N = 119), big ET-1 between 0...
June 15, 2018: Clinical Biochemistry
Jennifer Phung Woo, Leigh Christopher Reardon, Martin Cadeiras
No abstract text is available yet for this article.
June 16, 2018: Pancreas
Sevil Korkmaz-Icöz, Shiliang Li, Sivakkanan Loganathan, Tamás Radovits, Mihály Ruppert, Paige Brlecic, Alex Ali Sayour, Gábor Veres, Thomas Fleming, Maik Brune, Patrick Most, Matthias Karck, Gábor Szabó
OBJECTIVES: The use of 'marginal' hearts, such as from donors with diabetes mellitus (DM), could offer an opportunity to expand the donor pool in cardiac transplantation. Previous studies have shown that the phosphatidylinositol-3-kinase (PI3K)/Akt pathway is altered after ischaemia/reperfusion injury in the diabetic myocardium. We hypothesized that DM-induced cardiac dysfunction in donors is further impaired after heart transplantation and that PI3K/Akt-pathway alterations may be one of the underlying pathomechanisms...
June 14, 2018: Interactive Cardiovascular and Thoracic Surgery
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