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Proton Pump Inhibitors Increase Risk

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https://www.readbyqxmd.com/read/28717153/proton-pump-inhibitors-and-the-risk-for-fracture-at-specific-sites-data-mining-of-the-fda-adverse-event-reporting-system
#1
Liwei Wang, Mei Li, Yuying Cao, Zhengqi Han, Xueju Wang, Elizabeth J Atkinson, Hongfang Liu, Shreyasee Amin
Proton pump inhibitors (PPIs) are widely used to treat gastric acid-related disorders. Concerns have been raised about potential fracture risk, especially at the hip, spine and wrist. However, fracture risk at other bone sites has not been as well studied. We investigated the association between PPIs and specific fracture sites using an aggregated knowledge-enhanced database, the Food and Drug Administration Adverse Event Reporting System Data Mining Set (AERS-DM). Proportional reporting ratio (PRR) was used to detect statistically significant associations (signals) between PPIs and fractures...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717077/gastric-hyperplastic-polyps-associated-with-proton-pump-inhibitor-use-in-a-case-without-a-history-of-helicobacter-pylori-infection
#2
Shuichi Miyamoto, Mototsugu Kato, Kana Matsuda, Satoshi Abiko, Momoko Tsuda, Takeshi Mizushima, Keiko Yamamoto, Shoko Ono, Takahiko Kudo, Yuichi Shimizu, Kanako C Hatanaka, Izumi Tsunematsu, Naoya Sakamoto
A 56-year-old man with gastroesophageal reflux disease (GERD) was referred to our hospital. Esophagogastroduodenoscopy (EGD) revealed no evidence of any polypoid lesions in the stomach, and the patient had no history of Helicobacter pylori infection. He received omeprazole (20 mg) once daily for the GERD. EGD was performed at 1 year after the start of omeprazole administration, and this time, gastric hyperplastic polyps (GHPs) were detected. The GHPs increased in size as the omeprazole treatment continued, but they markedly decreased in size following omeprazole discontinuation...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28715344/community-acquired-pneumonia-incidence-before-and-after-proton-pump-inhibitor-prescription-population-based-study
#3
Fatmah Othman, Colin J Crooks, Timothy R Card
Objective To examine the risk of community acquired pneumonia before and after prescription of proton pump inhibitor (PPI) and assess whether unmeasured confounding explains this association.Design Cohort study and self controlled case series.Setting Clinical Practice Research Datalink (1990 to 2013) in UK.Participants Adult patients with a new prescription for a PPI individually matched with controls.Main outcome measures Association of community acquired pneumonia with PPI prescription estimated by three methods: a multivariable Cox model comparing risk in PPI exposed patients with controls, corrected for potential confounders; a self controlled case series; and a prior event rate ratio (PERR) analysis over the 12 month periods before and after the first PPI prescription...
November 15, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28695906/no-association-between-proton-pump-inhibitor-use-and-risk-of-alzheimer-s-disease
#4
Heidi Taipale, Anna-Maija Tolppanen, Miia Tiihonen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen
OBJECTIVES: The objective of the study was to investigate whether proton pump inhibitor (PPI) use is associated with an increased risk of clinically verified Alzheimer's disease (AD). METHODS: A Finnish nationwide nested case-control study MEDALZ includes all community-dwelling individuals with newly diagnosed AD during 2005-2011 (N=70,718), and up to four age-, sex-, and region of residence-matched comparison individuals for each case (N=282,858). Data were extracted from Finnish nationwide health-care registers...
July 11, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28680175/outcome-after-discontinuation-of-proton-pump-inhibitors-at-a-residential-care-site-quality-improvement-project
#5
Candy Lee, Anita Lo, Kiran Ubhi, Michael Milewski
BACKGROUND: Increased prescribing of proton pump inhibitors (PPIs) in the past few decades can be attributed mainly to long-term use of this type of therapy. Recent evidence indicates signals of harm associated with long-term use of PPIs, such as increased risk of Clostridium difficile infection, recurrence of C. difficile infection, and fracture. A few studies have assessed the effectiveness of step-down management of patients receiving long-term PPI therapy in ambulatory care settings...
May 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28678044/randomized-clinical-trial-the-impact-of-gastrointestinal-risk-factor-screening-and-prophylactic-proton-pump-inhibitor-therapy-in-patients-receiving-dual-antiplatelet-therapy
#6
Berit E S Jensen, Jane M Hansen, Kasper S Larsen, Anders B Junker, Jens F Lassen, Svend E Jensen, Ove B Schaffalitzky de Muckadell
OBJECTIVE: Dual antiplatelet therapy reduces the risk of ischemic complications after acute coronary syndrome, but increases the risk of bleeding including upper gastrointestinal bleeding (UGIB).The aim of this study was to examine the effect of screening for risk of UGIB and prophylactic proton pump inhibitor (PPI) treatment in dual-antiplatelet-treated patients at risk of UGIB and to assess the significance of dual antiplatelet therapy compliance for cardiovascular events. PATIENTS AND METHODS: In a register-based randomized-controlled trial, 2009 patients were included at the time of first percutaneous coronary intervention and randomized to either screening or control...
July 3, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28676480/risk-of-death-among-users-of-proton-pump-inhibitors-a-longitudinal-observational-cohort-study-of-united-states-veterans
#7
Yan Xie, Benjamin Bowe, Tingting Li, Hong Xian, Yan Yan, Ziyad Al-Aly
OBJECTIVE: Proton pump inhibitors (PPIs) are widely used, and their use is associated with increased risk of adverse events. However, whether PPI use is associated with excess risk of death is unknown. We aimed to examine the association between PPI use and risk of all-cause mortality. DESIGN: Longitudinal observational cohort study. SETTING: US Department of Veterans Affairs. PARTICIPANTS: Primary cohort of new users of PPI or histamine H2 receptor antagonists (H2 blockers) (n=349 312); additional cohorts included PPI versus no PPI (n=3 288 092) and PPI versus no PPI and no H2 blockers (n=2 887 030)...
July 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28672282/increasing-incidence-of-multiply-recurrent-clostridium-difficile-infection-in-the-united-states-a-cohort-study
#8
Gene K Ma, Colleen M Brensinger, Qufei Wu, James D Lewis
Background: Clostridium difficile infection (CDI), the most common health care-associated infection, often recurs. Fecal microbiota transplantation is increasingly used to treat multiply recurrent CDI (mrCDI). Objective: To determine whether the incidence of mrCDI is increasing in proportion to CDI and to identify risk factors for mrCDI. Design: Retrospective cohort study. Setting: United States. Participants: 38 911 718 commercially insured patients in the OptumInsight Clinformatics Database, of whom 45 341 developed CDI...
July 4, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28664276/surgically-treated-osteonecrosis-and-osteomyelitis-of-the-jaw-and-oral-cavity-in-patients-highly-adherent-to-alendronate-treatment-a-nationwide-user-only-cohort-study-including-over-60-000-alendronate-users
#9
P A Eiken, D Prieto-Alhambra, R Eastell, B Abrahamsen
Osteonecrosis of the jaw (ONJ) is rare (2.53/10,000 person-years) among alendronate users, but long-term and compliant use are associated with an increased risk of surgically treated ONJ. Risk of surgically treated ONJ is higher in patients with rheumatoid diseases and use of proton pump inhibitors. INTRODUCTION: ONJ is a rare event in users of oral bisphosphonates. Our aims were to evaluate if the risk of surgically treated ONJ increases with longer or more compliant treatment with alendronate for osteoporosis and to identify risk factors for surgically treated ONJ...
June 29, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28644310/predictors-of-mortality-in-cirrhosis-inpatients-with-clostridium-difficile-infection
#10
Elliot Z Smith, Patrick G Northup, Curtis K Argo
BACKGROUND: Clostridium difficile is a bacterial pathogen associated with significant morbidity and mortality in patients with cirrhosis. GOALS: Our primary aim is to identify variables that are predictive of poor outcomes in cirrhosis patients with C. difficile infection (CDI). We also aim to further characterize the risk factors for developing CDI and risk of mortality in this patient population. STUDY: A total of 200 subjects with a diagnosis of cirrhosis and CDI were matched to 200 cirrhosis inpatients without CDI...
June 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28642210/rationale-and-design-for-a-randomized-comparison-of-efficacy-and-safety-between-aspirin-and-clopidogrel-in-atrial-fibrillation-patients-with-low-stroke-risk-cesac-af-trial
#11
Sang Min Park, Haemin Jeong, Mi-Hyang Jung, Kyung Soon Hong, Myeong-Ki Hong, Chang Seok Bang, Christopher Y Kim
BACKGROUND: Atrial fibrillation (AF) increases the risk of thromboembolic stroke. An oral anticoagulant should be administrated to prevent stroke in patients with moderate stroke risk (ie, CHA2DS2-VASc score>2). If the stroke risk is low (i.e. the score=1), however, antiplatelet agent such as aspirin is widely used. Aspirin can cause peptic ulcer disease (PUD) while its alternative, clopidogrel, theoretically does not. OBJECTIVE: To elucidate the efficacy and safety between aspirin and clopidogrel, a multicenter randomized controlled trial was designed in AF patients with low stroke risk...
June 19, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28632255/intake-of-proton-pump-inhibitors-is-associated-with-an-increased-risk-of-dental-implant-failure
#12
Bruno Ramos Chrcanovic, Jenö Kisch, Tomas Albrektsson, Ann Wennerberg
PURPOSE: To investigate the association between the intake of proton pump inhibitors (PPIs) and the risk of dental implant failure. MATERIALS AND METHODS: The present retrospective cohort study is based on patients consecutively treated between 1980 and 2014 with implant-supported/retained prostheses at one specialist clinic. Modern endosseous dental implants with cylindrical or conical design were included, and only complete cases were considered; ie, only those implants with information available for all variables measured were included in the regression model analysis...
June 20, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28622955/age-specific-risks-severity-time-course-and-outcome-of-bleeding-on-long-term-antiplatelet-treatment-after-vascular-events-a-population-based-cohort-study
#13
Linxin Li, Olivia C Geraghty, Ziyah Mehta, Peter M Rothwell
BACKGROUND: Lifelong antiplatelet treatment is recommended after ischaemic vascular events, on the basis of trials done mainly in patients younger than 75 years. Upper gastrointestinal bleeding is a serious complication, but had low case fatality in trials of aspirin and is not generally thought to cause long-term disability. Consequently, although co-prescription of proton-pump inhibitors (PPIs) reduces upper gastrointestinal bleeds by 70-90%, uptake is low and guidelines are conflicting...
June 13, 2017: Lancet
https://www.readbyqxmd.com/read/28596229/implementation-of-a-proton-pump-inhibitor-stewardship-program
#14
Kelly W Davis, Rachel E Hanners, Sean M Lockwood
PURPOSE: The development and implementation of a proton pump inhibitor (PPI) stewardship program at a single institution are described. SUMMARY: Due to the overuse of PPIs and the increasing awareness of the adverse drug events associated with long-term PPI therapy, the pharmacy and internal medicine services of a medical center implemented a PPI stewardship program. All patients admitted to the internal medicine service were evaluated by the PPI stewardship team to determine if they had an appropriate indication for PPI continuation in the hospital as well as after discharge...
June 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28593484/reflux-sleeve-dilation-and-barrett-s-esophagus-after-laparoscopic-sleeve-gastrectomy-long-term-follow-up
#15
Daniel Moritz Felsenreich, Ronald Kefurt, Martin Schermann, Philipp Beckerhinn, Ivan Kristo, Michael Krebs, Gerhard Prager, Felix B Langer
BACKGROUND: Laparoscopic sleeve gastrectomy (SG) has become the most frequently performed bariatric procedure worldwide. De novo reflux might impact patients' quality of life, requiring lifelong proton pump inhibitor medication. It also increases the risk of esophagitis and formation of Barrett's metaplasia. Besides weight regain, gastroesophageal reflux disease (GERD) is the most common reason for conversion to Roux-en-Y gastric bypass. METHODS: We performed 24-h pH metries, manometries, gastroscopies, and questionnaires focusing on reflux (GIQLI, RSI) in SG patients with a follow-up of more than 10 years who did not suffer from symptomatic reflux or hiatal hernia preoperatively...
June 8, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28591820/proton-pump-inhibitors-nephropathy-and-cardiovascular-disease-in-type-2-diabetes-the-fremantle-diabetes-study
#16
Timothy M E Davis, Jocelyn Drinkwater, Wendy A Davis
Context: There is emerging evidence of a range of adverse effects of chronic proton pump inhibitor (PPI) therapy. Objective: To assess the impact of PPI use on albuminuria, renal function and cardiovascular disease (CVD) risk in type 2 diabetes. Design: Longitudinal observational study. Setting: Urban-dwelling community. Patients: Patients with type 2 diabetes from the longitudinal observational Fremantle Diabetes Study Phase II and on stable renin-angiotensin system blocking therapy were divided into those remaining untreated with a PPI (Group 1, n=686), on PPI therapy throughout (Group 2, n=174), and commencing (Group 3, n=109) or discontinuing regular PPI therapy (Group 4, n=67) during the two years between assessments...
June 7, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28588208/human-dimethylarginine-dimethylaminohydrolase-1-inhibition-by-proton-pump-inhibitors-and-the-cardiovascular-risk-marker-asymmetric-dimethylarginine-in-vitro-and-in-vivo-significance
#17
S Tommasi, D J Elliot, J A Hulin, B C Lewis, M McEvoy, A A Mangoni
Proton pump inhibitor (PPI)-induced inhibition of dimethylarginine dimethylaminohydrolase 1 (DDAH1), with consequent accumulation of the nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA), might explain the increased cardiovascular risk with PPI use. However, uncertainty exists regarding whether clinical PPI concentrations significantly inhibit DDAH1 under linear initial rate conditions, and whether PPI-induced DDAH1 inhibition significantly increases ADMA in humans. DDAH1 inhibition by esomeprazole, omeprazole, pantoprazole, lansoprazole and rabeprazole was determined by quantifying DDAH1-mediated L-citrulline formation in vitro...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28583827/association-between-proton-pump-inhibitor-use-and-risk-of-progression-of-chronic-kidney-disease
#18
Derk C F Klatte, Alessandro Gasparini, Hong Xu, Pietro de Deco, Marco Trevisan, Anna L V Johansson, Björn Wettermark, Johan Ärnlöv, Cynthia J Janmaat, Bengt Lindholm, Friedo W Dekker, Josef Coresh, Morgan E Grams, Juan J Carrero
BACKGROUND & AIMS: Proton pump inhibitors (PPI) have been associated with acute kidney injury (AKI) and recent studies suggest that they may be associated with the risk of chronic kidney disease (CKD). METHODS: We performed a retrospective analysis using the Stockholm creatinine measurements database, which contains information on diagnoses, dispensation claims, and laboratory test results for all citizens in the Stockholm region from 2007 through 2010. We identified new users of PPIs (n= 105305) and new users of H2 blockers (H2B; n= 9578); data on renal outcomes were collected for a median 2...
June 2, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28572098/prophylactic-acid-suppressive-therapy-in-hospitalized-adults-indications-benefits-and-infectious-complications
#19
Andrew C Faust, Kelly L Echevarria, Rebecca L Attridge, Lyndsay Sheperd, Marcos I Restrepo
Acid-suppressive therapy for prophylaxis of stress ulcer bleeding is commonly prescribed for hospitalized patients. Although its use in select, at-risk patients may reduce clinically significant gastrointestinal bleeding, the alteration in gastric pH and composition may place these patients at a higher risk of infection. Although any pharmacologic alteration of the gastric pH and composition is associated with an increased risk of infection, the risk appears to be highest with proton pump inhibitors, perhaps owing to the potency of this class of drugs in increasing the gastric pH...
June 2017: Critical Care Nurse
https://www.readbyqxmd.com/read/28569554/non-steroidal-anti-inflammatory-drug-related-upper-gastrointestinal-bleeding-types-of-drug-use-and-patient-profiles-in-real-clinical-practice
#20
Carlos Sostres, Patrica Carrera-Lasfuentes, Angel Lanas
BACKGROUND: The best available evidence regarding non-steroidal anti-inflammatory drug (NSAID)-related gastrointestinal (GI) bleeding comes from randomized controlled trials including patients who use NSAIDs to manage chronic rheumatic diseases; however, patients with varying background profiles commonly take NSAIDs for many other reasons, often without prescription, and such usage has not been well studied. OBJECTIVES AND METHODS: To define the characteristics of patients hospitalized for upper GI bleeding in clinical practice, we conducted a case-control study among patients with endoscopy-proven major upper GI bleeding due to gastroduodenal peptic lesions and control subjects...
July 5, 2017: Current Medical Research and Opinion
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