keyword
MENU ▼
Read by QxMD icon Read
search

Proton Pump Inhibitors Increase Risk

keyword
https://www.readbyqxmd.com/read/29675988/dose-dependent-impact-of-proton-pump-inhibitors-on-the-clinical-course-of-spontaneous-bacterial-peritonitis
#1
Tammo L Tergast, Anika Wranke, Hans Laser, Svetlana Gerbel, Michael P Manns, Markus Cornberg, Benjamin Maasoumy
BACKGROUND & AIMS: Spontaneous bacterial peritonitis (SBP) is a severe complication in patients with liver cirrhosis leading to acute kidney injury (AKI), hepatic encephalopathy (HE) and a high mortality. In this study we aimed to investigate the impact of proton pump inhibitors (PPI) and the potential relevance of the taken dosage on the incidence and clinical course of SBP. METHODS: Overall, 613 consecutive patients with decompensated liver cirrhosis were included...
April 19, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29671413/non-variceal-upper-gastrointestinal-bleeding
#2
REVIEW
Angel Lanas, Jean-Marc Dumonceau, Richard H Hunt, Mitsuhiro Fujishiro, James M Scheiman, Ian M Gralnek, Helen E Campbell, Alaa Rostom, Càndid Villanueva, Joseph J Y Sung
Non-variceal upper gastrointestinal bleeding (NVUGIB) is bleeding that develops in the oesophagus, stomach or proximal duodenum. Peptic ulcers, caused by Helicobacter pylori infection or use of NSAIDs and low-dose aspirin (LDA), are the most common cause. Although the incidence and mortality associated with NVUGIB have been decreasing owing to considerable advances in the prevention and management of NVUGIB over the past 20 years, it remains a common clinical problem with an annual incidence of ∼67 per 100,000 individuals in the United States in 2012...
April 19, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29644725/acid-suppressive-drugs-and-risk-of-kidney-disease-a-systematic-review-and-meta-analysis
#3
Tingting Qiu, Junwen Zhou, Chao Zhang
BACKGROUND AND AIM: More concerns had been raised about the risk of kidney disease (KD) associated with acid-suppressive drugs (ASDs). But whether they could directly increase such risk remained unclear. Meta-analysis was conducted to comprehensively investigate this relationship. METHODS: PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and three Chinese databases were searched until April 2017 for observational studies investigating the associations between ASDs and KD...
April 12, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29629278/association-of-proton-pump-inhibitor-use-with-renal-outcomes-in-patients-with-coronary-artery-disease
#4
Nam-Jun Cho, Chi-Young Choi, Samel Park, Sang-Ho Park, Eun Young Lee, Hyo-Wook Gil
Background: Several studies have suggested that proton pump inhibitor (PPI) use is associated with adverse renal outcomes, but obvious evidence for this association is lacking. We investigated the association between PPI use and adverse renal outcomes in patients who had undergone percutaneous coronary intervention. Methods: Of the 1,284 patients hospitalized for percutaneous coronary intervention between January 2007 and May 2012, 934 patients with baseline estimated glomerular filtration rate greater than 60 mL/min/1...
March 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/29628172/-impact-of-an-evaluation-of-the-professional-practices-on-the-relevance-of-proton-pump-inhibitors-prescriptions-pertinence-at-the-hospital
#5
A Daumas, E Garros, H Mendizabal, S Gayet, F Bernard, D Bagnères, A-L Demoux, P Rossi, P Villani, B Granel
INTRODUCTION: Proton pump inhibitors (PPI) are widely prescribed for unrecognized indications, at high a dose and for a long duration, in spite of side effects and numerous drug interactions. In 2009, the HAS (French Health Authority) published recommendations of good prescription but the latter are poorly respected. In this context of over prescription and additional cost for the society, we performed a professional practice evaluation of on the model of the Deming wheel. The objective of this work was to optimize the relevance of the prescriptions of the IPP in two services of internal medicine and geriatrics through an evaluation of the professional practices...
April 5, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29606940/successful-fecal-microbiota-transplantation-in-a-patient-with-severe-complicated-clostridium-difficile-infection-after-liver-transplantation
#6
REVIEW
Kai Markus Schneider, Theresa H Wirtz, Daniela Kroy, Stefanie Albers, Ulf Peter Neumann, Till Strowig, Gernot Sellge, Christian Trautwein
Clostridium difficile infection (CDI) represents one of the most common healthcare-associated infections. Due to increasing numbers of recurrences and therapy failures, CDI has become a major disease burden. Studies have shown that fecal microbiota transplantation (FMT) can both be a safe and highly efficacious therapy for patients with therapy-refractory CDI. However, patients undergoing solid organ transplantation are at high risk for CDI due to long-term immunosuppression, previous antibiotic therapy, and proton pump inhibitor use...
January 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29603881/decreased-risk-for-microscopic-colitis-and-inflammatory-bowel-disease-among-patients-with-reflux-disease
#7
Amnon Sonnenberg, Kevin O Turner, Robert M Genta
BACKGROUND: Previous studies found an increased risk for microscopic colitis (MC) associated with proton pump inhibitors. In patients with ulcerative colitis (UC) or Crohn's disease (CD), proton pump inhibitors have been associated with an increased risk for IBD flares and impaired outcomes. AIMS: To test the epidemiologic associations between gastrooesophageal reflux disease (GERD) and MC, UC or CD in a large database. METHOD: The Miraca Life Sciences Database is a national electronic repository of histopathological records of patients distributed throughout the entire US...
March 31, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29603109/use-of-proton-pump-inhibitors-and-the-risk-of-acute-kidney-injury-among-patients-with-rheumatoid-arthritis-cohort-study
#8
Henrik Svanström, Marie Lund, Mads Melbye, Björn Pasternak
INTRODUCTION: Recent observational studies have indicated that use of proton pump inhibitors may be associated with adverse renal outcomes. The objective of this study was to investigate whether the use of proton pump inhibitors increases the risk of acute kidney injury among patients with rheumatoid arthritis. METHODS: We conducted the study as a historical prospective cohort study, including patients with rheumatoid arthritis, 30-84 years of age, during 2004-2015...
March 30, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29601438/proton-pump-inhibitors-and-infant-pneumonia-other-lower-respiratory-tract-infections-national-nested-case-control-study
#9
Mei-Ling Blank, Lianne Parkin, Jiaxu Zeng, David Barson
OBJECTIVE: The possible association between the use of proton pump inhibitors (PPIs) and community-acquired pneumonia (CAP) or any lower respiratory tract infection (LRTI) remains uncertain. We conducted a nested case-control study using routinely collected national health and drug dispensing data in New Zealand to examine the risk of CAP or any LRTI resulting in hospitalization or death in infants dispensed a PPI. STUDY DESIGN: The cohort included 21,991 patients without a history of CAP or any LRTI who were born between 1 January 2005 and 31 December 2012 and were dispensed omeprazole, lansoprazole, or pantoprazole (the PPIs available in New Zealand during the study period) on at least one occasion during the first year of life...
March 29, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29599181/proton-pump-inhibitor-therapy-after-helicobacter-pylori-eradication-may-increase-the-risk-of-gastric-cancer
#10
REVIEW
Mimi Chang Tan, David Y Graham
No abstract text is available yet for this article.
March 29, 2018: BMJ evidence-based medicine
https://www.readbyqxmd.com/read/29568537/a-province-wide-cross-sectional-study-of-demographics-and-medication-use-of-patients-in-hemodialysis-units-across-ontario
#11
Marisa Battistella, Racquel Jandoc, Jeremy Y Ng, Eric McArthur, Amit X Garg
Background: Hemodialysis patients are at an increased risk of polypharmacy as they have the highest pill burden of all chronically ill patient populations, with an estimated average of 12 medications per day. Objectives: The aim of this study was to evaluate prescribing patterns of outpatient medications in patients receiving in-center hemodialysis. This was done to identify potential candidate medications for future quality improvement initiations to optimize prescribing...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29561973/proton-pump-inhibitors-increase-the-overall-risk-of-developing-bacterial-infections-in-patients-with-cirrhosis
#12
Illce B Lázaro-Pacheco, Alfredo I Servín-Caamaño, José L Pérez-Hernández, Gabriela Rojas-Loureiro, Luis Servín-Abad, Fátima Higuera-DE LA Tijera
BACKGROUND: Acid suppression has been associated with adverse events; such as, enteric infections. Proton pump inhibitors (PPI) are frequently prescribed in patients with cirrhosis, but is unclear if PPI are associated with the development of bacterial infections in these patients. OBJECTIVE: To assess the impact of PPI intake on the development of bacterial, viral and fungal infections in patients with cirrhosis. METHODS: An observational, retrospective, historic cohort study...
January 2018: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/29538319/self-reported-fractures-in-dermatitis-herpetiformis-compared-to-coeliac-disease
#13
Camilla Pasternack, Eriika Mansikka, Katri Kaukinen, Kaisa Hervonen, Timo Reunala, Pekka Collin, Heini Huhtala, Ville M Mattila, Teea Salmi
Dermatitis herpetiformis (DH) is a cutaneous manifestation of coeliac disease. Increased bone fracture risk is known to associate with coeliac disease, but this has been only scantly studied in DH. In this study, self-reported fractures and fracture-associated factors in DH were investigated and compared to coeliac disease. Altogether, 222 DH patients and 129 coeliac disease-suffering controls were enrolled in this study. The Disease Related Questionnaire and the Gastrointestinal Symptom Rating Scale and Psychological General Well-Being questionnaires were mailed to participants; 45 out of 222 (20%) DH patients and 35 out of 129 (27%) of the coeliac disease controls had experienced at least one fracture ( p = 0...
March 14, 2018: Nutrients
https://www.readbyqxmd.com/read/29536002/impact-of-a-restriction-in-reimbursement-on-proton-pump-inhibitors-in-patients-with-an-increased-risk-of-gastric-complications
#14
Linda E Flinterman, Karin Hek, Joke C Korevaar, Liset van Dijk
Governments have several options to reduce the increasing costs of health care, including restrictions for the reimbursement of medicines. Next to the intended effect of reduced costs for medicines, reimbursement restriction can have unintended effects such as patients refraining from their treatment which may lead to health problems and increased use of health care. An example of a reimbursement restriction is the one for proton pump inhibitors (PPIs) that became effective in the Netherlands in January 2012...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29521726/lacrimal-drainage-obstruction-and-gastroesophageal-reflux-disease-a-nationwide-longitudinal-cohort-study
#15
Tyler Hyungtaek Rim, JaeSang Ko, Sung Soo Kim, Jin Sook Yoon
GOALS: This study aimed to evaluate the association between gastroesophageal reflux disease (GERD) and development of lacrimal drainage obstruction (LDO). BACKGROUND: It has been hypothesized that GERD may contribute toward the development of LDO. STUDY: This was a retrospective study of Koreans aged 40 to 79 years registered in the Korean National Health Screening Cohort from 2002 to 2013. Incident cases of LDO were identified according to the Korean Classification of Disease...
March 7, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29508411/proton-pump-inhibitor-use-and-risk-of-hip-fractures-among-community-dwelling-persons-with-alzheimer-s-disease-a-nested-case-control-study
#16
S Torvinen-Kiiskinen, A-M Tolppanen, M Koponen, A Tanskanen, J Tiihonen, S Hartikainen, H Taipale
BACKGROUND: Hip fractures are a major health concern among older persons with Alzheimer's disease, who usually use many concomitant drugs for several diseases. Evidence of the association between proton pump inhibitor use and risk of hip fracture is contradictory. AIM: To investigate whether the long-term use of proton pump inhibitor is associated with risk of hip fractures among community-dwelling persons with Alzheimer's disease. METHODS: In this nested case-control study, the nationwide MEDALZ data were utilised...
March 6, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29493043/proton-pump-inhibitor-use-and-the-risk-of-fractures-among-an-older-adult-cohort
#17
Barbara N Harding, Noel S Weiss, Rod L Walker, Eric B Larson, Sascha Dublin
PURPOSE: The purpose of the study is to determine if the use of a proton pump inhibitor (PPI) is associated with an increased fracture risk, as some prior studies have suggested. METHODS: This retrospective cohort study included data on 4438 participants aged 65 and older who had no fracture in the year prior to baseline and had ≥5 years of enrollment history in Kaiser Permanente Washington, an integrated healthcare delivery system in Seattle, WA, during 1994 to 2014...
February 28, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29477057/maintenance-proton-pump-inhibition-therapy-and-risk-of-oesophageal-cancer
#18
Nele Brusselaers, Lars Engstrand, Jesper Lagergren
BACKGROUND: The association of long-term use of proton pump inhibitors (PPIs) with oesophageal adenocarcinoma has been poorly defined. Our aim was to assess the risk of oesophageal cancer assessing confounding by indication. METHODS: This population-based cohort study included all 796,492 adults exposed to maintenance therapy with PPIs in Sweden in 2005-2012. Standardised incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated to assess the risk of oesophageal adenocarcinoma (and squamous cell carcinoma as a comparison) among long-term PPI users relative to the corresponding background population...
April 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29475806/effects-of-gastroprotectant-drugs-for-the-prevention-and-treatment-of-peptic-ulcer-disease-and-its-complications-a-meta-analysis-of-randomised-trials
#19
Benjamin Scally, Jonathan R Emberson, Enti Spata, Christina Reith, Kelly Davies, Heather Halls, Lisa Holland, Kate Wilson, Neeraj Bhala, Christopher Hawkey, Marc Hochberg, Richard Hunt, Loren Laine, Angel Lanas, Carlo Patrono, Colin Baigent
BACKGROUND: Gastroprotectant drugs are used for the prevention and treatment of peptic ulcer disease and might reduce its associated complications, but reliable estimates of the effects of gastroprotectants in different clinical settings are scarce. We aimed to examine the effects of proton-pump inhibitors (PPIs), prostaglandin analogues, and histamine-2 receptor antagonists (H2RAs) in different clinical circumstances by doing meta-analyses of tabular data from all relevant unconfounded randomised trials of gastroprotectant drugs...
February 20, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29458991/prevalence-of-the-risk-factors-for-qt-prolongation-and-associated-drug-drug-interactions-in-a-cohort-of-medical-inpatients
#20
Qasim Khan, Mohammad Ismail, Iqbal Haider, Zahid Ali
BACKGROUND/PURPOSE: Medical inpatients are at increased risk of QT interval prolongation due to multiple risk actors and QT prolonging drugs. This study aimed to identify the prevalence of risk factors for QT prolongation; QT prolonging medications; associated drug-drug interactions (QT-DDIs); their predictors; and TdP (torsades de pointes) risks of drugs. METHODS: This cohort study was carried out in medical wards of two tertiary hospitals in Khyber Pakhtunkhwa, Pakistan...
February 16, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
keyword
keyword
119228
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"