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Charlson age comorbidity index

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https://www.readbyqxmd.com/read/28747255/adjuvant-gemcitabine-docetaxel-chemotherapy-for-stage-i-uterine-leiomyosarcoma-trends-and-survival-outcomes
#1
Ramey D Littell, Lue-Yen Tucker, Tina Raine-Bennett, Ted E Palen, Eve Zaritsky, Romain Neugebauer, Julia Embry-Schubert, Scott E Lentz
OBJECTIVE: To assess recent trends of administering adjuvant gemcitabine-docetaxel (GD) chemotherapy for Stage I uterine leiomyosarcoma, and to compare disease-free and overall survival between women who received and did not receive adjuvant GD chemotherapy. METHODS: All patients diagnosed with Stage I uterine leiomyosarcoma in a California-Colorado population-based health plan inclusive of 2006-2013 were included in a retrospective cohort. Adjuvant GD chemotherapy rates, clinico-pathologic characteristics and survival estimates were assessed...
July 24, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28746360/synergistic-effects-of-cognitive-impairment-on-physical-disability-in-all-cause-mortality-among-men-aged-80-years-and-over-results-from-longitudinal-older-veterans-study
#2
Wan-Chen Yu, Ming-Yueh Chou, Li-Ning Peng, Yu-Te Lin, Chih-Kuang Liang, Liang-Kung Chen
OBJECTIVE: We evaluated effects of the interrelationship between physical disability and cognitive impairment on long-term mortality of men aged 80 years and older living in a retirement community in Taiwan. METHODS: This prospective cohort study enrolled older men aged 80 and older living in a Veterans Care Home. Those with confirmed diagnosis of dementia were excluded. All participants received comprehensive geriatric assessment, including sociodemographic data, Charlson's Comorbidity Index (CCI), geriatric syndromes, activities of daily living (ADL) using the Barthel index and cognitive function using the Mini-Mental State Examination (MMSE)...
2017: PloS One
https://www.readbyqxmd.com/read/28746223/decreasing-incidence-and-mortality-among-hospitalized-patients-suffering-a-ventilator-associated-pneumonia-analysis-of-the-spanish-national-hospital-discharge-database-from-2010-to-2014
#3
Javier de Miguel-Díez, Ana López-de-Andrés, Valentín Hernández-Barrera, Isabel Jiménez-Trujillo, Manuel Méndez-Bailón, José M de Miguel-Yanes, Benito Del Rio-Lopez, Rodrigo Jiménez-García
The aim of this study was to describe trends in the incidence and outcomes of ventilator-associated pneumonia (VAP) among hospitalized patients in Spain (2010-2014).This is a retrospective study using the Spanish national hospital discharge database from year 2010 to 2014. We selected all hospital admissions that had an ICD-9-CM code: 997.31 for VAP in any diagnosis position. We analyzed incidence, sociodemographic and clinical characteristics, procedures, pathogen isolations, and hospital outcomes.We identified 9336 admissions with patients suffering a VAP...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28737988/patterns-of-care-for-biologic-dosing-outliers-and-nonoutliers-in-biologic-naive-patients-with-rheumatoid-arthritis
#4
Thomas Delate, Roxanne Meyer, Daniel Jenkins
BACKGROUND: Although most biologic medications for patients with rheumatoid arthritis (RA) have recommended fixed dosing, actual biologic dosing may vary among real-world patients, since some patients can receive higher (high-dose outliers) or lower (low-dose outliers) doses than what is recommended in medication package inserts. OBJECTIVE: To describe the patterns of care for biologic-dosing outliers and nonoutliers in biologic-naive patients with RA. METHODS: This was a retrospective, longitudinal cohort study of patients with RA who were not pregnant and were aged ≥ 18 and < 90 years from an integrated health care delivery system...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28737986/real-world-adherence-and-persistence-to-oral-disease-modifying-therapies-in-multiple-sclerosis-patients-over-1-year
#5
Kristen M Johnson, Huanxue Zhou, Feng Lin, John J Ko, Vivian Herrera
BACKGROUND: Disease-modifying therapies (DMTs) are indicated to reduce relapse rates and slow disease progression for relapsing-remitting multiple sclerosis (MS) patients when taken as prescribed. Nonadherence or non-persistence in the real-world setting can lead to greater risk for negative clinical outcomes. Although previous research has demonstrated greater adherence and persistence to oral DMTs compared with injectable DMTs, comparisons among oral DMTs are lacking. OBJECTIVE: To compare adherence, persistence, and time to discontinuation among MS patients newly prescribed the oral DMTs fingolimod, dimethyl fumarate, or teriflunomide...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28737985/evaluation-of-patient-migration-patterns-and-related-health-care-costs-within-a-national-medicare-advantage-prescription-drug-plan-after-implementation-of-an-oxycodone-hcl-extended-release-access-restriction
#6
Chi-Chang Chen, Ajita P De, Brian Sweet, Rolin L Wade
BACKGROUND: Health plans use formulary restrictions (e.g., prior authorization, step therapy, tier change, nonformulary status) in an effort to control cost and promote quality, safety, and appropriate prescription utilization. Some Medicare payers perceive that the inclusion of certain agents, such as branded oxycodone HCl extended-release tablets (OERs), on their formularies is associated with attracting high-cost members to the plan. OBJECTIVE: To evaluate disenrollment rates, patient migration, and subsequent health care costs among OER users who disenrolled from a national Medicare Advantage Prescription Drug plan (study-MAPD) in the plan year following OER nonformulary restriction...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28732186/assessing-the-impact-of-surgeon-experience-on-urinary-continence-recovery-after-robot-assisted-radical-prostatectomy-results-of-four-high-volume-surgeons
#7
Nicola Fossati, Ettore Di Trapani, Giorgio Gandaglia, Paolo Dell'Oglio, Paolo Umari, Nicolò Maria Buffi, Giorgio Guazzoni, Alexander Mottrie, Franco Gaboardi, Francesco Montorsi, Alberto Briganti, Nazareno Suardi
PURPOSE: To test the impact of surgeon experience on urinary continence (UC) recovery after robot-assisted radical prostatectomy (RARP). MATERIALS AND METHODS: The study included 1477 consecutive patients treated with RARP by four surgeons between 2006 and 2014. UC recovery was defined as being completely dry over a 24-hour period at follow-up. Surgeon experience was coded as the total number of RARP performed by the surgeon before the patient's operation. Multivariable analysis tested the association between surgeon experience and UC recovery...
July 21, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28730775/charlson-comorbidity-index-for-evaluati%C3%AE-n-%C3%AE-f-the-outcomes-of-elderly-patients-undergoing-laparoscopic-surgery-for-colon-cancer
#8
Yun Huang, Yuxing Zhang, Jianjun Li, Gang Liu
PURPOSE: We investigated the effectiveness of the Charlson comorbidity index (CCI) for predicting postoperative 30-day complications and long-term survival outcomes of elderly patients who underwent laparoscopic surgery for colon cancer with radical intent. METHODS: We reviewed 178 patients aged ≥70 years who underwent laparoscopic surgery for colon cancer with radical intent between January 2008 and December 2015. Patients were divided into high CCI (CCI ≥ 3; n=71) and low CCI (CCI < 3; n=107) groups for comparative analyses of differences in their short- and long-term outcomes...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28729248/end-stage-renal-disease-versus-death-in-a-portuguese-cohort-of-elderly-patients-an-approach-using-competing-event-analysis
#9
Josefina Santos, Isabel Fonseca, Jorge Malheiro, Idalina Beirao, Luisa Lobato, Pedro Oliveira, Antonio Cabrita
Chronic kidney disease (CKD) is higher in elderly, but mortality outweighs the risk of end-stage renal disease (ESRD). Our aim was to identify prognostic markers for ESRD or death in elderly CKD, within a competing-risk analysis. This is a longitudinal study of consecutive newly referred patients with CKD ages 65 years, followed until the time of the first event (ESRD or death), using a competing-risk analysis. A modified Charlson Comorbidity Index (mCCI) was subdivided into subgroups (0-2, 3-4, ≥5). Patients were followed for hospitalizations that occurred prior to the outcomes...
July 19, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28726018/association-of-vagotomy-and-decreased-risk-of-subsequent-ischemic-stroke-in-complicated-peptic-ulcer-patients-an-asian-population-study
#10
Chu-Wen Fang, Chun-Hung Tseng, Shih-Chi Wu, William Tzu-Liang Chen, Chih-Hsin Muo
OBJECTIVES: The primary management of peptic ulcers is medical treatment. Persistent exacerbation of a peptic ulcer may lead to complications (perforation and/or bleeding). There has been a trend toward the use of a less invasive surgical simple suture, simple local suture or non-operative (endoscopic/angiography) hemostasis rather than acid-reducing vagotomy (i.e., vagus nerve severance) for treating complicated peptic ulcers. Other studies have shown the relationship between high vagus nerve activity and survival in cancer patients via reduced levels of inflammation, indicating the essential role of the vagus nerve...
July 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28719660/factors-associated-with-life-sustaining-treatment-restriction-in-a-general-intensive-care-unit
#11
Stein Arve Skjaker, Henrik Hoel, Vegard Dahl, Knut Stavem
PURPOSE: Few previous studies have investigated associations between clinical variables available after 24 hours in the intensive care unit (ICU), including the Charlson Comorbidity Index (CCI), and decisions to restrict life-sustaining treatment. The aim of this study was to identify factors associated with the life-sustaining treatment restriction and to explore if CCI contributes to explaining decisions to restrict life-sustaining treatment in the ICU at a university hospital in Norway from 2007 to 2009...
2017: PloS One
https://www.readbyqxmd.com/read/28719079/associations-between-drugs-and-small-bowel-mucosal-bleeding-a-multicenter-capsule-endoscopy-study
#12
Ryota Niikura, Atsuo Yamada, Koutarou Maki, Masanao Nakamura, Hirotsugu Watabe, Mitsuhiro Fujishiro, Shiro Oka, Motohiro Esaki, Shunji Fujimori, Atsushi Nakajima, Naoki Ohmiya, Takayuki Matsumoto, Shinji Tanaka, Kazuhiko Koike, Choitsu Sakamoto
OBJECTIVES: Although several drugs may induce small-bowel mucosal injuries, it is unclear whether these injuries contribute to overt small-bowel bleeding. This study was designed to evaluate the associations between drug use and small-bowel mucosal injury and between these mucosal injuries and overt bleeding in a disease-relevant population. METHODS: We retrospectively studied patients with suspected small-bowel diseases who underwent capsule endoscopy between 2010 and 2013...
July 18, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28716070/comorbidity-and-metabolic-syndrome-in-patients-with-multiple-sclerosis-from-asturias-and-catalonia-spain
#13
Antoni Sicras-Mainar, Elena Ruíz-Beato, Ruth Navarro-Artieda, Jorge Maurino
BACKGROUND: The impact of comorbidity on multiple sclerosis (MS) is a new area of interest. Limited data on the risk factors of metabolic syndrome (MetS) is currently available. The aim of this study was to estimate the presence of comorbid conditions and MetS in a sample of adult patients with MS. METHODS: A retrospective, cohort study was conducted using electronic medical records from 19 primary care centres in Catalonia and Asturias, Spain. The number of chronic diseases (diagnoses), the Charlson Comorbidity Index and the individual Case-mix Index were used to assess general comorbidity variables...
July 17, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28712548/excess-mortality-between-2007-and-2014-among-patients-with-clostridium-difficile-infection-a-french-health-insurance-database-analysis
#14
F Barbut, S Bouée, L Longepierre, M Goldberg, C Bensoussan, L Levy-Bachelot
BACKGROUND: The impact of CDI (Clostridium difficile infections) on mortality is controversial. AIM: To assess excess mortality due to CDI in France. METHOD: Two cohorts of patients with CDI and a cohort of matched controls were extracted from a 1% representative sample of subjects covered by the general health insurance system in France (EGB database, 660,000 patients). The CDI patients were hospitalized with CDI as a principal diagnosis (PD) or an associated diagnosis (AD) between 2007 and 2014, but not in 2006...
July 13, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28711537/increased-risk-of-anxiety-or-depression-after-traumatic-spinal-cord-injury-in-patients-with-pre-existing-hyperlipidemia-a-population-based-study
#15
Sher-Wei Lim, Tee-Tau Eric Nyam, Chung-Han Ho, Yow-Ling Shiue, Jhi-Joung Wang, Chung-Ching Chio, Jinn-Rung Kuo
OBJECTIVE: Anxiety or depression (AD) is a common complication after traumatic spinal cord injury (tSCI). This study sought to investigate the role of pre-existing hyperlipidemia in new-onset AD after tSCI using a longitudinal population database. METHODS: This retrospective cohort study used Longitudinal Health Insurance Database data from January 1997 to December 2011. The case and comparison groups were individuals who experienced tSCI and who did and did not have pre-existing hyperlipidemia, respectively...
July 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28709115/development-and-validation-of-the-korea-dementia-comorbidity-index-kdci-a-nationwide-population-based-cohort-study-from-2002-to-2013
#16
Jae-Hyun Kim, Ki-Bong Yoo, Yunhwan Lee
This study develop and validate a simple and accessible measure of comorbidity, named the Korean Dementia Comorbidity index (KDCI), to assist in predicting the onset of dementia. This study used the National Health Insurance Service-Cohort Sample Database from 2002 to 2013 (n=23,856). Cox proportional hazard model was used to estimate incident dementia (International Classification of Disease, 10th edition (ICD-10) codes: F00-F03, G30, G311), with a hazard ratio higher than 1.05 for each comorbid condition being assigned a score...
September 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28707992/transitional-care-services-a-quality-and-safety-process-improvement-program-in-neurosurgery
#17
Faith C Robertson, Jessica L Logsdon, Hormuzdiyar H Dasenbrock, Sandra C Yan, Siobhan M Raftery, Timothy R Smith, William B Gormley
OBJECTIVE Readmissions increasingly serve as a metric of hospital performance, inviting quality improvement initiatives in both medicine and surgery. However, few readmission reduction programs have targeted surgical patient populations. The objective of this study was to establish a transitional care program (TCP) with the goal of decreasing length of stay (LOS), improving discharge efficiency, and reducing readmissions of neurosurgical patients by optimizing patient education and postdischarge surveillance...
July 14, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28702893/medical-costs-of-treating-breast-cancer-among-younger-medicaid-beneficiaries-by-stage-at-diagnosis
#18
Justin G Trogdon, Donatus U Ekwueme, Diana Poehler, Cheryll C Thomas, Katherine Reeder-Hayes, Benjamin T Allaire
BACKGROUND: Younger women (aged 18-44 years) diagnosed with breast cancer often face more aggressive tumors, higher treatment intensity, and lower survival rates than older women. In this study, we estimated incident breast cancer costs by stage at diagnosis and by race for younger women enrolled in Medicaid. METHODS: We analyzed cancer registry data linked to Medicaid claims in North Carolina from 2003 to 2008. We used Surveillance, Epidemiology, and End Results (SEER) Summary 2000 definitions for cancer stage...
July 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28701858/early-experience-in-starting-a-laparoscopic-liver-resection-program-in-greece
#19
Georgios C Sotiropoulos, Nikolaos Machairas, Ioannis D Kostakis, Paraskevas Stamopoulos, Petros Charalampoudis, Stylianos Kykalos, Gregory Kouraklis, Dimitrios Mantas
BACKGROUND AND OBJECTIVES: Laparoscopic liver resections (LLRs) have gained wider acceptance during the decade as safe and efficient procedures in the management of several benign and malignant diseases when performed by experienced surgeons. We report our initial institutional experience with LLRs performed by 1 certified hepatobiliary surgeon. METHODS: Patients undergoing LLRs by 1 senior hepatobiliary surgeon in our Institution during the period from January 2012 through January 2017 were prospectively sampled and retrospectively analyzed for the purposes of this study...
January 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/28699940/association-of-stress-biomarkers-with-30-day-unplanned-readmission-and-death
#20
Carole Aubert, Antoine Folly, Mancinetti Marco, Daniel Hayoz, Jacques Donze
BACKGROUND: The theory that posthospitalization stress might increase the risk of postdischarge complications has never been investigated. OBJECTIVE: To assess whether serum levels of stress biomarkers at discharge are associated with readmission and death after an acute-care hospitalization. DESIGN: We prospectively included 346 patients aged ≥50 years admitted to the department of general internal medicine at a large community hospital between April 8, 2013 and September 23, 2013...
July 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
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