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Veronica J Barkowski, Neil A Embleton
OBJECTIVE: To describe the surgical technique, clinical efficacy, and complications using the Simitri Stable in Stride(®) extracapsular articulating implant (EAI) to treat naturally occurring stifle instability due to cranial cruciate ligament (CrCL) insufficiency. STUDY DESIGN: Prospective case series. ANIMALS: Client-owned dogs with CrCL-deficient stifles (n=60 dogs; 66 stifles). METHODS: An EAI was applied to the medial aspect of the distal femur and proximal tibia after stifle exploration and treatment of joint pathology...
August 2016: Veterinary Surgery: VS
Gina E Bertocci, Nathan P Brown, Neil A Embleton, Veronica J Barkowski
OBJECTIVE: To evaluate the influence of the Simitri Stable in Stride™ extracapsular articulating implant (EAI) on canine stifle biomechanics in the cranial cruciate ligament (CrCL)-deficient stifle using a 3-dimensional (3D) quasi-static rigid body canine pelvic limb computer model simulating the stance phase of gait. STUDY DESIGN: Computer simulations. ANIMALS: Five-year-old neutered male golden retriever (33 kg). METHODS: The EAI was implemented in a previously developed 3D CrCL-deficient canine pelvic limb computer simulation model...
April 2016: Veterinary Surgery: VS
Neil A Embleton, Veronica J Barkowski
A 5-year-old Labrador retriever mixed breed dog was presented for an acute non-weight-bearing left hind limb lameness. A stifle disruption was diagnosed. The patient was treated using a novel extracapsular articulated stifle stabilizing implant (Simitri™). Twelve weeks after surgery the patient had full range of motion of the affected stifle and had begun to return to pre-injury activity. This is the first reported case of this condition being surgically managed successfully in this manner.
February 2015: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
José M Peregrín-Alvarez, John Parkinson
To date the genomes of over 600 organisms have been generated of which 100 are from eukaryotes. Together with partial genome data for an additional 700 eukaryotic organisms, these exceptional sequence resources offer new opportunities to explore phylogenetic relationships and species diversity. The identification of highly diverse sequences specific to an EST-based sequence dataset offers insights into the extent of genetic novelty within that dataset. Sequences that are only shared with other related species from the same taxon might represent genes associated with taxon-specific innovations...
2009: Methods in Molecular Biology
Minghua Wang, Felix D Guerrero, Geo Pertea, Vishvanath M Nene
BACKGROUND: The southern cattle tick, Rhipicephalus (Boophilus) microplus, is an economically important parasite of cattle and can transmit several pathogenic microorganisms to its cattle host during the feeding process. Understanding the biology and genomics of R. microplus is critical to developing novel methods for controlling these ticks. RESULTS: We present a global comparative genomic analysis of a gene index of R. microplus comprised of 13,643 unique transcripts assembled from 42,512 expressed sequence tags (ESTs), a significant fraction of the complement of R...
2007: BMC Genomics
José M Peregrín-Alvarez, Andrew Yam, Gaya Sivakumar, John Parkinson
Owing to the high costs involved, only 28 eukaryotic genomes have been fully sequenced to date. On the other hand, an increasing number of projects have been initiated to generate survey sequence data for a large number of other eukaryotic organisms. For the most part, these data are poorly organized and difficult to analyse. Here, we present PartiGeneDB (, a publicly available database resource, which collates and processes these sequence datasets on a species-specific basis to form non-redundant sets of gene objects-which we term partial genomes...
January 1, 2005: Nucleic Acids Research
John Parkinson, Claire Whitton, Ralf Schmid, Marian Thomson, Mark Blaxter
NEMBASE (available at is a publicly available online database providing access to the sequence and associated meta-data currently being generated as part of the Edinburgh-Wellcome Trust Sanger Institute parasitic nematode EST project. NEMBASE currently holds approximately 100 000 sequences from 10 different species of nematode. To facilitate ease of use, sequences have been processed to generate a non-redundant set of gene objects ('partial genome') for each species. Users may query the database on the basis of BLAST annotation, sequence similarity or expression profiles...
January 1, 2004: Nucleic Acids Research
John Parkinson, Mark Blaxter
Global sequence comparisons between large datasets, such as those arising from genome projects, can be problematic to display and analyze. We have developed SimiTri, a Java/Perl-based application, which allows simultaneous display and analysis of relative similarity relationships of the dataset of interest to three different databases. We illustrate its utility in identifying Caenorhabditis elegans genes that have distinct patterns of phylogenetic affinity suggestive of horizontal gene transfer. SimiTri is freely downloadable from http://www...
February 12, 2003: Bioinformatics
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