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JOURNAL ARTICLE
Leon A Steiner, David Crompton, Srdjan Sumarac, Artur Vetkas, Jürgen Germann, Maximilian Scherer, Maria Justich, Alexandre Boutet, Milos R Popovic, Mojgan Hodaie, Suneil K Kalia, Alfonso Fasano, William D Hutchison Wd, Andres M Lozano, Milad Lankarany, Andrea A Kühn, Luka Milosevic
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) produces an electrophysiological signature called evoked resonant neural activity (ERNA); a high-frequency oscillation that has been linked to treatment efficacy. However, the single-neuron and synaptic bases of ERNA are unsubstantiated. This study proposes that ERNA is a subcortical neuronal circuit signature of DBS-mediated engagement of the basal ganglia indirect pathway network. In people with Parkinson's disease, we: (i) showed that each peak of the ERNA waveform is associated with temporally-locked neuronal inhibition in the STN; (ii) characterized the temporal dynamics of ERNA; (iii) identified a putative mesocircuit architecture, embedded with empirically-derived synaptic dynamics, that is necessary for the emergence of ERNA in silico; (iv) localized ERNA to the dorsal STN in electrophysiological and normative anatomical space; (v) used patient-wise hotspot locations to assess spatial relevance of ERNA with respect to DBS outcome; and (vi) characterized the local fiber activation profile associated with the derived group-level ERNA hotspot...
April 11, 2024: Nature Communications
#22
JOURNAL ARTICLE
Tijana Šćepanović, Miloš Kojić, Mladen Mikić, Valdemar Štajer, Uğur Ödek, Ana Penjak
INTRODUCTION: This research aims to determine the effects of an integrative warm-up method on the range of motion in joints of the lower extremities, the strength of the stabilizer trunk muscles, and the quality of the basic movement patterns in older adolescents. METHODS: The study sample consisted of 88 male students (age 20.1 ± 0.5). They were randomly divided into four groups: one control group (CG) ( n = 17; 180.8 ± 7...
2024: Frontiers in sports and active living
#23
JOURNAL ARTICLE
Zorka Vasiljevic, Jovana Vunduk, Dragana Bartolic, Goran Miskovic, Milos Ognjanovic, Nenad B Tadic, Maria Vesna Nikolic
Emission of greenhouse gases and infectious diseases caused by improper agro-waste disposal has gained significant attention in recent years. To overcome these hurdles, agro-waste can be valorized into valuable bioactive compounds that act as reducing or stabilizing agents in the synthesis of nanomaterials. Herein, we report a simple circular approach using Citrus reticulata Blanco ( C. reticulata ) waste (peel powder/aqueous extract) as green reducing and capping/stabilizing agents and Zn nitrate/acetate precursors to synthesize ZnO nanoparticles (NPs) with efficient antimicrobial and photocatalytic activities...
April 10, 2024: ACS Applied Bio Materials
#24
JOURNAL ARTICLE
Josep Rizo, Levent Sari, Klaudia Jaczynska, Christian Rosenmund, Milo M Lin
The SNAP receptor (SNARE) proteins syntaxin-1, SNAP-25, and synaptobrevin mediate neurotransmitter release by forming tight SNARE complexes that fuse synaptic vesicles with the plasma membranes in microseconds. Membrane fusion is generally explained by the action of proteins on macroscopic membrane properties such as curvature, elastic modulus, and tension, and a widespread model envisions that the SNARE motifs, juxtamembrane linkers, and C-terminal transmembrane regions of synaptobrevin and syntaxin-1 form continuous helices that act mechanically as semirigid rods, squeezing the membranes together as they assemble ("zipper") from the N to the C termini...
April 16, 2024: Proceedings of the National Academy of Sciences of the United States of America
#25
JOURNAL ARTICLE
Jan Bartáček, Karel Chlumský, Jan Mrkvička, Lucie Paloušová, Miloš Sedlák, Pavel Drabina
The new chiral ligands I-III based on derivatives of imidazolidin-4-one were synthesised and characterised. The catalytic activity and enantioselectivity of their corresponding copper(II) complexes were studied in asymmetric Henry reactions. It was found that the enantioselectivity of these catalysts is overall very high and depends on the relative configuration of the ligand used; cis- configuration of ligand affords the nitroaldols with major enantiomer S- (up to 97% ee), whereas the application of ligands with trans -configuration led to nitroaldols with major R -enantiomer (up to 96% ee)...
2024: Beilstein Journal of Organic Chemistry
#26
JOURNAL ARTICLE
Miloš Z Stojanović, Dragan Krasić, Predrag Radović, Miloš Trajkovic, Andrija Ćosić, Vladimir Petrović, Pavle Pešić
BACKGROUND Oral squamous cell carcinoma (OSCC) is the most common of head and neck malignancies in well-developed countries. In most cases, patients with OSCC experience a degree of nutritional status disturbances and decreased quality of life (QoL). This study aimed to compare nutritional status and QoL in 51 patients before and after surgery for OSCC. MATERIAL AND METHODS Fifty-one eligible patients with OSCC were followed during a 3-year period (2019-2022). For all patients, we determined body mass index (BMI), serum albumin (ALB), prognostic nutritional index, and nutritional risk index before and after treatment...
April 6, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
#27
JOURNAL ARTICLE
Jovana Ilkic, Milos Milovanovic, Valentina Marinkovic
BACKGROUND: Digital technologies are present in every phase of a drug lifecycle, from drug design and development to its dispensing and use. However, given the rapid development and implementation of digital solutions, their monitoring, evaluation and risk assessment are limited and lacking. OBJECTIVE: This research is aiming to identify potential errors, quantify and prioritize associated risks in the context of certain technologies used in pharmaceutical care, as well as define corrective measures to improve patient safety and the quality of pharmaceutical care...
April 3, 2024: Journal of the American Pharmacists Association: JAPhA
#28
JOURNAL ARTICLE
Nernst-Atwood Raphael, Pierre Anthony Garraud, Maroussia Roelens, Jean Patrick Alfred, Milo Richard, Janne Estill, Olivia Keiser, Aziza Merzouki
OBJECTIVES: This study assesses tuberculosis (TB) treatment outcomes in Haiti. METHODS: Data from drug-susceptible patients with TB (2018-2019) were analyzed using the Fine & Gray model with multiple imputation. RESULTS: Of the 16,545 patients, 14.7% had concurrent HIV coinfection, with a 66.2% success rate. The median treatment duration was 5 months, with patients averaging 30 years (with an interquartile range of 22-42 years). The estimated hazard of achieving a successful treatment outcome decreased by 2...
June 2024: IJID Reg
#29
JOURNAL ARTICLE
Yonatan Harnik, Anat Milo
Molecular representation learning (MRL) is a specialized field in which deep-learning models condense essential molecular information into a vectorized form. Whereas recent research has predominantly emphasized drug discovery and bioactivity applications, MRL holds significant potential for diverse chemical properties beyond these contexts. The recently published study by King-Smith introduces a novel application of molecular representation training and compellingly demonstrates its value in predicting molecular properties (E...
April 3, 2024: Chemical Science
#30
REVIEW
Kim F T Jochems, Dominik Menges, Dafne Sanchez, Nienke A de Glas, Hans Wildiers, Daniel Eberli, Milo A Puhan, Esther Bastiaannet
INTRODUCTION: Older patients are often deemed ineligible for clinical research, and many frequently-used endpoints and outcome measures are not as relevant for older patients for younger ones. This systematic review aimed to present an overview of outcomes used in clinical research regarding patients over the age of 65 years with prostate cancer. MATERIALS AND METHODS: PubMed and Embase were systematically searched to identify studies on prostate cancer (treatment) in patients aged ≥65 between 2016 and 2023...
April 3, 2024: Journal of Geriatric Oncology
#31
JOURNAL ARTICLE
Shira Milo, Ritah Namawejje, Roi Krispin, Shay Covo
The repair capacity of ultra-violet (UV) light DNA damage is important for adaptation of fungi to different ecological niches. We previously showed that in the soil-borne pathogen Fusarium oxysporum photo-reactivation dependent UV repair is induced at the germling stage and reduced at the filament stage. Here, we tested the developmental control of the transcription of photolyase, UV survival, UV repair capacity, and UV induced mutagenesis in the foliar pathogen Fusarium mangiferae. Unlike F. oxysporum, neither did we observe developmental control over photo-reactivation dependent repair nor the changes in gene expression of photolyase throughout the experiment...
April 2024: Fungal Biology
#32
Prashant S Emani, Jason J Liu, Declan Clarke, Matthew Jensen, Jonathan Warrell, Chirag Gupta, Ran Meng, Che Yu Lee, Siwei Xu, Cagatay Dursun, Shaoke Lou, Yuhang Chen, Zhiyuan Chu, Timur Galeev, Ahyeon Hwang, Yunyang Li, Pengyu Ni, Xiao Zhou, Trygve E Bakken, Jaroslav Bendl, Lucy Bicks, Tanima Chatterjee, Lijun Cheng, Yuyan Cheng, Yi Dai, Ziheng Duan, Mary Flaherty, John F Fullard, Michael Gancz, Diego Garrido-Martin, Sophia Gaynor-Gillett, Jennifer Grundman, Natalie Hawken, Ella Henry, Gabriel E Hoffman, Ao Huang, Yunzhe Jiang, Ting Jin, Nikolas L Jorstad, Riki Kawaguchi, Saniya Khullar, Jianyin Liu, Junhao Liu, Shuang Liu, Shaojie Ma, Michael Margolis, Samantha Mazariegos, Jill Moore, Jennifer R Moran, Eric Nguyen, Nishigandha Phalke, Milos Pjanic, Henry Pratt, Diana Quintero, Ananya S Rajagopalan, Tiernon R Riesenmy, Nicole Shedd, Manman Shi, Megan Spector, Rosemarie Terwilliger, Kyle J Travaglini, Brie Wamsley, Gaoyuan Wang, Yan Xia, Shaohua Xiao, Andrew C Yang, Suchen Zheng, Michael J Gandal, Donghoon Lee, Ed S Lein, Panos Roussos, Nenad Sestan, Zhiping Weng, Kevin P White, Hyejung Won, Matthew J Girgenti, Jing Zhang, Daifeng Wang, Daniel Geschwind, Mark Gerstein
Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the brain. Yet, little is understood about how genetic variants influence cell-level gene expression. Addressing this, we uniformly processed single-nuclei, multi-omics datasets into a resource comprising >2.8M nuclei from the prefrontal cortex across 388 individuals. For 28 cell types, we assessed population-level variation in expression and chromatin across gene families and drug targets. We identified >550K cell-type-specific regulatory elements and >1...
March 30, 2024: bioRxiv
#33
JOURNAL ARTICLE
Theodora Panagaki, Lucia Janickova, Dunja Petrovic, Karim Zuhra, Tamás Ditrói, Eszter P Jurányi, Olivier Bremer, Kelly Ascenção, Thilo M Philipp, Péter Nagy, Milos R Filipovic, Csaba Szabo
Down syndrome (DS) is a genetic condition where the person is born with an extra chromosome 21. DS is associated with accelerated aging; people with DS are prone to age-related neurological conditions including an early-onset Alzheimer's disease. Using the Dp(17)3Yey/ + mice, which overexpresses a portion of mouse chromosome 17, which encodes for the transsulfuration enzyme cystathionine β-synthase (CBS), we investigated the functional role of the CBS/hydrogen sulfide (H2 S) pathway in the pathogenesis of neurobehavioral dysfunction in DS...
April 1, 2024: GeroScience
#34
JOURNAL ARTICLE
Levent Sari, Sofia Bali, Lukasz A Joachimiak, Milo M Lin
Protein fibril self-assembly is a universal transition implicated in neurodegenerative diseases. Although fibril structure/growth are well characterized, fibril nucleation is poorly understood. Here, we use a computational-experimental approach to resolve fibril nucleation. We show that monomer hairpin content quantified from molecular dynamics simulations is predictive of experimental fibril formation kinetics across a tau motif mutant library. Hairpin trimers are predicted to be fibril transition states; one hairpin spontaneously converts into the cross-beta conformation, templating subsequent fibril growth...
March 29, 2024: Nature Communications
#35
JOURNAL ARTICLE
Ines Kovačić, Manuela Miloš, Matej Kurkutović, Asja Čelebić, Nikola Petričević
BACKGROUND: Fulfilling aesthetic norms is an imperative of modern society. Accordingly, aesthetics has found its important role in dental medicine. The aim was to study whether there is a difference in the perception of tooth shade change and anatomical variations of anterior maxillary teeth among dental students depending on the level of education, gender, and experience in assisting in a dental office. METHODS: The research was conducted among dental students via the Google Forms platform...
March 28, 2024: BMC Oral Health
#36
JOURNAL ARTICLE
Miloš Tišma, Florian Patrick Bock, Jacob Kerssemakers, Hammam Antar, Aleksandre Japaridze, Stephan Gruber, Cees Dekker
Bacterial chromosomes are folded into tightly regulated three-dimensional structures to ensure proper transcription, replication, and segregation of the genetic information. Direct visualization of chromosomal shape within bacterial cells is hampered by cell-wall confinement and the optical diffraction limit. Here, we combine cell-shape manipulation strategies, high-resolution fluorescence microscopy techniques, and genetic engineering to visualize the shape of unconfined bacterial chromosome in real-time in live Bacillus subtilis cells that are expanded in volume...
March 28, 2024: Nature Communications
#37
RANDOMIZED CONTROLLED TRIAL
Milica Karadžić Kočica, Arsen Ristić, Ivan Soldatović, Dejan Lazović, Jelena Čumić, Miloš Grujić, Radmila Karan, Duško Terzić, Ivan Palibrk, Mladen Kočica, Dejan Marković
Cardiac surgery (CS) with extracorporeal circulation (ECC), induces intense oxidative stress (OS) and systemic inflammatory response (SIR), which may seriously affect postoperative lung function. We aimed to test if high parenteral (200 mg/kg/24 h) daily doses of Vitamin C (VitC), given within 48 h after the beginning of the operation, may reduce the incidence and severity of postoperative pulmonary complications (PPCs) in CS patients. This single-center, prospective, randomized, single-blinded, interventional trial included 150 patients, assigned to control Group A ( n = 75) and interventional Group B ( n = 75)...
March 7, 2024: Nutrients
#38
JOURNAL ARTICLE
Nenad Mitrović, Zorana Golubović, Aleksandra Mitrović, Milan Travica, Isaak Trajković, Miloš Milošević, Aleksandar Petrović
The three-point bending test is a valuable method for evaluating the mechanical properties of 3D-printed biomaterials, which can be used in various applications. The use of 3D printing in specimen preparation enables precise control over material composition and microstructure, facilitating the investigation of different printing parameters and advanced materials. The traditional approach to analyzing the mechanical properties of a material using a three-point bending test has the disadvantage that it provides only global information about the material's behavior...
March 14, 2024: Micromachines
#39
JOURNAL ARTICLE
Suzana Matijašević Joković, Aleksandra Korać, Sanja Kovačević, Ana Djordjević, Lidija Filipović, Zorana Dobrijević, Miloš Brkušanin, Dušanka Savić-Pavićević, Ivan Vuković, Milica Popović, Goran Brajušković
Prostate-specific membrane antigen (PSMA) and caveolin-1 are membrane proteins that are overexpressed in prostate cancer (PCa) and are involved in tumor growth and increase in aggressiveness. The aim of the present study is therefore to evaluate PSMA and caveolin-1 proteins from plasma exosomes as effective liquid biopsy biomarkers for PCa. This study included 39 patients with PCa and 33 with benign prostatic hyperplasia (BPH). The shape and size of the exosomes were confirmed by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) analysis...
March 21, 2024: International Journal of Molecular Sciences
#40
JOURNAL ARTICLE
Angèle Sorel Achounna, David Ordaz-Rosado, Janice García-Quiroz, Gabriela Morales-Guadarrama, Edgar Milo-Rocha, Fernando Larrea, Lorenza Díaz, Rocío García-Becerra
HER2-positive breast cancer is associated with aggressive behavior and reduced survival rates. Calcitriol restores the antiproliferative activity of antiestrogens in estrogen receptor (ER)-negative breast cancer cells by re-expressing ERα. Furthermore, calcitriol and its analog, EB1089, enhance responses to standard anti-cancer drugs. Therefore, we aimed to investigate EB1089 effects when added to the combined treatment of lapatinib and antiestrogens on the proliferation of HER2-positive breast cancer cells...
March 9, 2024: International Journal of Molecular Sciences
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