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Milo Cullinan, Michael Clarke, Tim Dallman, Steven Peart, Deborah Wilson, Daniel Weiand
Introduction. It is estimated up to 6 % of prosthetic vascular grafts become infected. Staphylococcus aureus is predominant in early infection and coagulase-negative staphylococci are predominant in late infections. Enterobacteriaceae cause 14-40 % of prosthetic vascular graft infections. This is, to our knowledge the first reported case of Salmonella gastroenteritis causing chronic prosthetic vascular graft infection (PVGI). Case presentation. A 57 years old lady presented with signs and symptoms of prosthetic vascular graft infection...
August 2017: JMM Case Reports
Igor Aharonovich, Milos Toth
No abstract text is available yet for this article.
October 13, 2017: Science
Dušana Čierna, Miloš Štefanovský, Lenka Matejová, Reidar P Lystad
OBJECTIVE: To determine the injury incidence rate (IIR) and injury pattern, and to identify risk factors for injury, among elite adult European judo athletes. DESIGN: Prospective cohort study. SETTING: The 2015 Under 23 European Judo Championships, Bratislava, Slovakia. PARTICIPANTS: All registered athletes (N = 295). INDEPENDENT VARIABLES: Sex, weight division, and fight outcome. MAIN OUTCOME MEASURES: Injury incidence rates were calculated per 1000 athlete-exposures (IIRAE) and per 1000 minutes of exposure (IIRME) with 95% confidence intervals (CI)...
October 11, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
David Novak, Milos Mojovic, Aleksandra Pavicevic, Martina Zatloukalova, Lenka Hernychova, Martin Bartosik, Jan Vacek
Cytochrome c (cyt c) is one of the most studied conjugated proteins due to its electron-transfer properties and ability to regulate the processes involved in homeostasis or apoptosis. Here we report an electrochemical strategy for investigating the electroactivity of cyt c and its analogs with a disrupted heme moiety, i.e. apocytochrome c (acyt c) and porphyrin cytochrome c (pcyt c). The electrochemical data are supplemented with low-temperature and spin-probe electron paramagnetic resonance (EPR) spectroscopy...
September 21, 2017: Bioelectrochemistry
Milos Radivojevic, Felix Franke, Michael Altermatt, Jan Müller, Andreas Hierlemann, Douglas J Bakkum
Axons are neuronal processes specialized for conduction of action potentials (APs). The timing and temporal precision of APs when they reach each of the synapses are fundamentally important for information processing in the brain. Due to small diameters of axons, direct recording of single AP transmission is challenging. Consequently, most knowledge about axonal conductance derives from modeling studies or indirect measurements. We demonstrate a method to noninvasively and directly record individual APs propagating along millimeter-length axonal arbors in cortical cultures with hundreds of microelectrodes at microsecond temporal resolution...
October 9, 2017: ELife
Sheng Hu, Zachary P L Laker, Hannah S Leese, Noelia Rubio, Martina De Marco, Heather Au, Mark S Skilbeck, Neil R Wilson, Milo S P Shaffer
Graphene and graphene nanoplatelets can be functionalised via a gas-phase thermochemical method; the approach is versatile, readily scalable, and avoids the introduction of additional defects by exploiting existing sites. Direct TEM imaging confirmed covalent modification of single layer graphene, without damaging the connectivity of the lattice, as supported by Raman spectrometry and AFM nano-indentation measurements of mechanical stiffness. The grafting methodology can also be applied to commercially-available bulk graphene nanoplatelets, as illustrated by the preparation of anionic, cationic, and non-ionic derivatives...
September 1, 2017: Chemical Science
Christa M Snyder, Xiaomei Zhou, Jonathan A Karty, Bryan R Fonslow, Milos V Novotny, Stephen C Jacobson
Through direct coupling of capillary electrophoresis (CE) to mass spectrometry (MS) with a sheathless interface, we have identified 77 potential N-glycan structures derived from human serum. We confirmed the presence of N-glycans previously identified by indirect methods, e.g., electrophoretic mobility standards, obtained 31 new N-glycan structures not identified in our prior work, differentiated co-migrating structures, and determined specific linkages on isomers featuring sialic acids. Serum N-glycans were cleaved from proteins, neutralized via methylamidation, and labeled with the fluorescent tag 8-aminopyrene-1,3,6-trisulfonic acid, which renders the glycan fluorescent and provides a -3 charge for electrophoresis and negative-mode MS detection...
September 9, 2017: Journal of Chromatography. A
Ruxandra-Iulia Milos, Maria Bernathova, Pascal A Baltzer, Katja Pinker-Domenig, Panagiotis Kapetas, Margaretha Rudas, Thomas H Helbich
No abstract text is available yet for this article.
October 5, 2017: European Journal of Radiology
Ibolja Cernak, Donald G Stein, Gregory A Elder, Stephn Ahlers, Kenneth Curley, Ralph G DePalma, John Duda, Milos Ikonomovic, Grant L Iverson, Firas Kobeissy, Vassilis E Koliatsos, Michael J Leggieri, Anthony M Pacifico, Douglas H Smith, Raymond Swanson, Floyd J Thompson, Frank C Tortella
As a follow-up to the 2008 state-of-the-art (SOTA) conference on traumatic brain injuries (TBIs), the 2015 event organized by the United States Department of Veterans Affairs (VA) Office of Research and Development (ORD) analysed the knowledge gained over the last 7 years as it relates to basic scientific methods, experimental findings, diagnosis, therapy, and rehabilitation of TBIs and blast-induced neurotraumas (BINTs). The current article summarizes the discussions and recommendations of the scientific panel attending the Preclinical Modeling and Therapeutic Development Workshop of the conference, with special emphasis on factors slowing research progress and recommendations for ways of addressing the most significant pitfalls...
2017: Brain Injury: [BI]
Yanbing Xue, Milos Hauskrecht
Annotation of classification data by humans can be a time-consuming and tedious process. Finding ways of reducing the annotation effort is critical for building the classification models in practice and for applying them to a variety of classification tasks. In this paper, we develop a new active learning framework that combines two strategies to reduce the annotation effort. First, it relies on label uncertainty information obtained from the human in terms of the Likert-scale feedback. Second, it uses active learning to annotate examples with the greatest expected change...
2017: Proceedings of the ... SIAM International Conference on Data Mining
Mattis Gärtner Nilsson, Veronica Milos Nymberg
No abstract text is available yet for this article.
October 3, 2017: Läkartidningen
Gai Milo, Ido Bogner, Younes Bathish, Moshe Lewin, Suheir Assady
End-stage renal disease (ESRD) is a major cause of morbidity and mortality worldwide. Survival of ESRD patients depends on renal replacement therapies, such as kidney transplantation and dialysis. Due to the shortage of potential kidney donors and patients' comorbidities, dialysis is the major therapeutic option offered to such patients. In this review, recent advances in hemodialysis and hemodiafiltration, and their potential impact on improving patient survival will be discussed.
September 2017: Harefuah
Erica Hinckson, Margaret Schneider, Sandra J Winter, Emily Stone, Milo Puhan, Afroditi Stathi, Michelle M Porter, Paul A Gardiner, Daniela Lopes Dos Santos, Andrea Wolff, Abby C King
BACKGROUND: Physical inactivity across the lifespan remains a public health issue for many developed countries. Inactivity has contributed considerably to the pervasiveness of lifestyle diseases. Government, national and local agencies and organizations have been unable to systematically, and in a coordinated way, translate behavioral research into practice that makes a difference at a population level. One approach for mobilizing multi-level efforts to improve the environment for physical activity is to engage in a process of citizen science...
September 29, 2017: International Journal of Behavioral Nutrition and Physical Activity
Milos Kovacevic, Oren Friedman, Frank Riedel, Jochen Wurm, Gregor M Bran
No abstract text is available yet for this article.
October 2017: Facial Plastic Surgery: FPS
Marija D Milošević, Milica G Paunović, Miloš M Matić, Branka I Ognjanović, Zorica S Saičić
Fenitrothion is widely used organophosphate pesticide in agriculture and health programs, but besides, it causes several toxic effects. The present study was designed to evaluate the possible protective effects of selenium (0.5mg/kg b.w.) and vitamin C (100mg/kg b.w) on altered haematological, biochemical and oxidative stress parameters in the blood of rats orally treated with fenitrothion (20mg/kg b.w) for 30days. Fenitrothion caused changes in body weight, food and water intake, and some haematological and biochemical parameters...
September 21, 2017: Environmental Toxicology and Pharmacology
A C V A Filho, P A S Rodrigues, S R Benjamin, R T T Paim, M O Holanda, J Y G Silva, T S Milo, I G P Vieira, M G R Queiroz, M I F Guedes
Carnauba wax is extracted from the leaves of the Copernicia prunífera and contains approximately 80% of esters in its composition. The purpose of the present study was evaluate the hypolipidemic effect of p-methoxycinnamic diesters (PCO-C) extracted from Copernicia prunífera in a model of acute and chronic dyslipidemia in mice. The levels of total cholesterol and triglycerides were significantly reduced plasma levels in PCO-C at the dose of 100mg/kg in a model of acute and chronic dyslipidemia. Histological studies showed that PCO-C has no hepatotoxic effect and reduces hepatic steatosis in animals that consumed hyperlipidemic ration...
September 21, 2017: Environmental Toxicology and Pharmacology
Meng Chen, Till B Puschmann, Pavel Marasek, Masaki Inagaki, Marcela Pekna, Ulrika Wilhelmsson, Milos Pekny
Vimentin is an intermediate filament (also known as nanofilament) protein expressed in several cell types of the central nervous system, including astrocytes and neural stem/progenitor cells. Mutation of the vimentin serine sites that are phosphorylated during mitosis (VIM (SA/SA) ) leads to cytokinetic failures in fibroblasts and lens epithelial cells, resulting in chromosomal instability and increased expression of cell senescence markers. In this study, we investigated morphology, proliferative capacity, and motility of VIM (SA/SA) astrocytes, and their effect on the differentiation of neural stem/progenitor cells...
September 27, 2017: Molecular Neurobiology
Milica G Paunović, Miloš M Matić, Branka I Ognjanović, Zorica S Saičić
Cadmium (Cd) is a major environmental pollutant, which exerts adverse effects mainly by inducing oxidative stress. Coenzyme Q10 (CoQ10) and vitamin E (VE), naturally occurring antioxidants, improve health condition by inactivating free radicals and enhancing antioxidative defence. The aim of our study was to investigate the protective role of CoQ10 and/or VE pretreatment against Cd-induced haematotoxicity. Wistar albino rats were intramuscularly injected with CoQ10 (20 mg/kg b.w.) and/or VE (20 IU/kg b.w.) or with saline (control group)...
October 2017: Toxicology and Industrial Health
Zdenek Kadanka, Blanka Adamova, Milos Kerkovsky, Zdenek Kadanka, Ladislav Dusek, Barbora Jurova, Eva Vlckova, Josef Bednarik
OBJECTIVES: To update a previously established list of predictors for neurological cervical cord dysfunction in nonmyelopathic degenerative cervical cord compression (NMDCCC). MATERIAL AND METHODS: A prospective observational follow-up study was performed in a cohort of 112 consecutive NMDCCC subjects (55 women and 57 men; median age 59 years, range 40-79 years), either asymptomatic (40 subjects) or presenting with cervical radiculopathy or cervical pain (72 subjects), who had completed a follow-up of at least 2 years (median duration 3 years)...
September 2017: Brain and Behavior
Aleksandra Pavićević, Jinghui Luo, Ana Popović-Bijelić, Miloš Mojović
Albumin is the most abundant plasma protein and as such has been the subject of many studies using a variety of techniques. One of them, capable of monitoring the conformational changes and the binding capacity of proteins, is electron paramagnetic resonance spectroscopy (EPR) spin labeling. To date, albumin has been investigated using a number of different spin labels, mostly spin-labeled fatty acids (SLFAs). However, albumin can bind up to seven equivalents of fatty acids, making it difficult to determine which parts of the molecule undergo conformational changes...
September 23, 2017: European Biophysics Journal: EBJ
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