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https://www.readbyqxmd.com/read/28227921/directionally-sensitive-peripheral-nerve-recording-bipolar-nerve-cuff-design
#1
Parisa Sabetian, Milos R Popovic, Paul B Yoo, Parisa Sabetian, Milos R Popovic, Paul B Yoo
Although bipolar nerve cuff electrodes (NCEs) are used in clinical neurostimulation therapies (e.g., epilepsy, obstructive sleep apnea), the use of this electrode as part of a closed-up controlled system is very limited. The literature points to high noise content (i.e., poor signal-to-noise ratio, SNR) as the primary reason for not using bipolar NCEs to record neural activity. In fact, over the past several decades, the pseudo-tripolar NCEs, the symmetric configuration of this electrode array (i.e., electrically-shorted side contacts) makes it very difficult to obtain directional information from the recorded neural activity (efferent vs...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227459/leg-fluid-accumulation-during-prolonged-sitting
#2
Daniel Vena, Jonathan Rubianto, Milos Popovic, Azadeh Yadollahi, Daniel Vena, Jonathan Rubianto, Milos Popovic, Azadeh Yadollahi, Daniel Vena, Azadeh Yadollahi, Jonathan Rubianto, Milos Popovic
The accumulation of fluid in the legs due to sedentariness can be a health risk in extreme cases. Negative health impacts associated with leg fluid accumulation include leg edema and risk of blood clots. Furthermore, fluid accumulating in the legs is accompanied by fluid shift into the upper body which is also associated with health risks such as: increased blood pressure when lying down, respiratory problems in people with heart failure, and increased sleep apnea. Understanding the pattern by which fluid accumulates in the legs can aid in the development of devices for reducing leg fluid accumulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224612/clopidogrel-paclitaxel-drug-drug-interaction-a-pharmacoepidemiologic-study
#3
K Agergaard, M Mau-Sørensen, T B Stage, T L Jørgensen, R E Hassel, K D Steffensen, J W Pedersen, M L H Milo, S H Poulsen, A Pottegård, J Hallas, K Brøsen, T K Bergmann
Paclitaxel is mainly eliminated by CYP2C8 in the liver. CYP2C8 is strongly inhibited by the clopidogrel metabolite acyl-β-D-glucuronide. To determine if this interaction has clinical relevance, we identified 48 patients treated with clopidogrel and paclitaxel using databases and a prescription register. Peripheral sensory neuropathy was retrospectively evaluated from medical charts and compared to that of 88 age and sex matched controls treated with paclitaxel and low dose aspirin. By a cumulative dose of 1500 mg paclitaxel, 35% of the patients had developed severe neuropathy...
February 22, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28220176/chemical-routes-to-discharging-graphenides
#4
Stephen A Hodge, David J Buckley, Hin Chun Yau, Neal T Skipper, Christopher A Howard, Milo S P Shaffer
Chemical and electrochemical reduction methods allow the dispersion, processing, and/or functionalization of discrete sp(2)-hybridised nanocarbons, including fullerenes, nanotubes and graphenes. Electron transfer to the nanocarbon raises the Fermi energy, creating nanocarbon anions and thereby activating an array of possible covalent reactions. The Fermi level may then be partially or fully lowered by intended functionalization reactions, but in general, techniques are required to remove excess charge without inadvertent covalent reactions that potentially degrade the nanocarbon properties of interest...
February 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28220118/advanced-strategies-in-immune-modulation-of-cancer-using-lipid-based-nanoparticles
#5
Shoshy Mizrahy, Inbal Hazan-Halevy, Dalit Landesman-Milo, Brandon D Ng, Dan Peer
Immunotherapy has a great potential in advancing cancer treatment, especially in light of recent discoveries and therapeutic interventions that lead to complete response in specific subgroups of melanoma patients. By using the body's own immune system, it is possible not only to specifically target and eliminate cancer cells while leaving healthy cells unharmed but also to elicit long-term protective response. Despite the promise, current immunotherapy is limited and fails in addressing all tumor types. This is probably due to the fact that a single treatment strategy is not sufficient in overcoming the complex antitumor immunity...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28218937/academic-detailing-pilot-for-naloxone-prescribing-among-primary-care-providers-in-san-francisco
#6
Emily Behar, Christopher Rowe, Glenn-Milo Santos, Nina Santos, Phillip O Coffin
BACKGROUND: Improving the safety of prescribed opioids in clinical settings is a national priority. While co-prescribing naloxone is increasingly recommended, there is little understanding of the optimal way to implement this practice. METHODS: We developed and delivered an academic detailing intervention to 40 randomly selected opioid-prescribing primary care providers in San Francisco from February to May 2015. Process outcomes were tracked and included provider demographics, number and type of contact attempts, reason for refusal (if applicable), name of detailer, duration of intervention, topics covered, provider concerns, and follow-up plan...
February 2017: Family Medicine
https://www.readbyqxmd.com/read/28218046/thyroid-transcription-factor-1-expression-is-associated-with-outcome-of-patients-with-non-squamous-non-small-cell-lung-cancer-treated-with-pemetrexed-based-chemotherapy
#7
Ondrej Fiala, Milos Pesek, Jana Skrickova, Vitezslav Kolek, Frantisek Salajka, Marcela Tomiskova, Monika Satankova, Juraj Kultan, Jana Kuliskova, Martin Svaton, Michal Hrnciarik, Karel Hejduk, Renata Chloupkova, Ondrej Topolcan, Helena Hornychova, Marketa Nova, Ales Ryska, Jindrich Finek
Pemetrexed is an antifolate cytostatic agent targeting several folate-dependent enzymatic pathways, widely used in the treatment of locally advanced or metastatic stage non-small cell lung cancer. Aside from the non-squamous histology, there is still no available molecular biomarker predicting treatment efficacy of pemetrexed-based chemotherapy. The aim of our retrospective study was to evaluate the association of thyroid transcription factor 1 expression with outcome of a large cohort of patients with non-squamous non-small cell lung cancer treated with pemetrexed...
February 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28215422/coronary-artery-bypass-graft-surgery-using%C3%A2-the-radial-artery-right-internal-thoracic-artery-or-saphenous-vein-as-the%C3%A2-second%C3%A2-conduit
#8
Robert F Tranbaugh, Thomas A Schwann, Daniel G Swistel, Kamellia R Dimitrova, Laila Al-Shaar, Darryl M Hoffman, Charles M Geller, Milo Engoren, Sandhya K Balaram, John D Puskas, Robert H Habib
BACKGROUND: It is not clear whether radial artery (RA), right internal thoracic artery (RITA), or saphenous vein (SV) is the preferred second bypass graft during coronary artery bypass graft surgery using the left internal thoracic artery (LITA) in patients aged less or greater than 70 years. METHODS: Late survival data were collected for 13,324 consecutive, isolated, primary coronary artery bypass graft surgery patients from three hospitals. Cox regression analysis was performed on all patients grouped by age...
February 16, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28208604/reducing-fall-risk-with-combined-motor-and-cognitive-training-in-elderly-fallers
#9
Francesco Barban, Roberta Annicchiarico, Matteo Melideo, Alessia Federici, Maria Giovanna Lombardi, Simone Giuli, Claudia Ricci, Fulvia Adriano, Ivo Griffini, Manuel Silvestri, Massimo Chiusso, Sergio Neglia, Sergio Ariño-Blasco, Raquel Cuevas Perez, Yannis Dionyssiotis, Georgios Koumanakos, Milo Kovačeić, Nuria Montero-Fernández, Oscar Pino, Niels Boye, Ulises Cortés, Cristian Barrué, Atia Cortés, Peter Levene, Stelios Pantelopoulos, Roberto Rosso, José Antonio Serra-Rexach, Angelo Maria Sabatini, Carlo Caltagirone
BACKGROUND: Falling is a major clinical problem in elderly people, demanding effective solutions. At present, the only effective intervention is motor training of balance and strength. Executive function-based training (EFt) might be effective at preventing falls according to evidence showing a relationship between executive functions and gait abnormalities. The aim was to assess the effectiveness of a motor and a cognitive treatment developed within the EU co-funded project I-DONT-FALL...
February 10, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28208370/emergent-pattern-formation-in-an-interstitial-biofilm
#10
Cameron Zachreson, Christian Wolff, Cynthia B Whitchurch, Milos Toth
Collective behavior of bacterial colonies plays critical roles in adaptability, survivability, biofilm expansion and infection. We employ an individual-based model of an interstitial biofilm to study emergent pattern formation based on the assumptions that rod-shaped bacteria furrow through a viscous environment and excrete extracellular polymeric substances which bias their rate of motion. Because the bacteria furrow through their environment, the substratum stiffness is a key control parameter behind the formation of distinct morphological patterns...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28202497/deficiency-of-the-angiotensinase-aminopeptidase-a-increases-susceptibility-to-glomerular-injury
#11
Juan Carlos Q Velez, Ehtesham Arif, Jessalyn Rodgers, Megan P Hicks, John M Arthur, Deepak Nihalani, Evelyn T Bruner, Milos N Budisavljevic, Carl Atkinson, Wayne R Fitzgibbon, Michael G Janech
Aminopeptidase A (APA) is expressed in glomerular podocytes and tubular epithelia and metabolizes angiotensin II (AngII), a peptide known to promote glomerulosclerosis. In this study, we tested whether APA expression changes in response to progressive nephron loss or whether APA exerts a protective role against glomerular damage and during AngII-mediated hypertensive kidney injury. At advanced stages of FSGS, fawn-hooded hypertensive rat kidneys exhibited distinctly increased APA staining in areas of intact glomerular capillary loops...
February 15, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28192396/metabotropic-action-of-postsynaptic-kainate-receptors-triggers-hippocampal-long-term-potentiation
#12
Milos M Petrovic, Silvia Viana da Silva, James P Clement, Ladislav Vyklicky, Christophe Mulle, Inmaculada M González-González, Jeremy M Henley
Long-term potentiation (LTP) in the rat hippocampus is the most extensively studied cellular model for learning and memory. Induction of classical LTP involves an NMDA-receptor- and calcium-dependent increase in functional synaptic AMPA receptors, mediated by enhanced recycling of internalized AMPA receptors back to the postsynaptic membrane. Here we report a physiologically relevant NMDA-receptor-independent mechanism that drives increased AMPA receptor recycling and LTP. This pathway requires the metabotropic action of kainate receptors and activation of G protein, protein kinase C and phospholipase C...
February 13, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28188010/the-1-min-sit-to-stand-test-in-cystic-fibrosis-insights-into-cardiorespiratory-responses
#13
Thomas Radtke, Helge Hebestreit, Milo A Puhan, Susi Kriemler
BACKGROUND: We aimed to characterize the cardiopulmonary response during a 1-min sit-to-stand (STS) test and compare peak exercise cardiorespiratory variables to a maximal cardiopulmonary exercise test (CPET) in cystic fibrosis (CF). We further aimed to assess the validity of the STS power index (PowerSTS) as a measure of exercise capacity. METHODS: Fifteen adult CF patients performed spirometry, CPET and the 1-min STS test with respiratory gas analysis. RESULTS: Peak-exercise cardiorespiratory variables during the 1-min STS test correlated strongly (r=0...
February 7, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28187669/description-of-a-new-species-of-the-genus-i-tophoderes-i-dejean-coleoptera-%C3%A2-anthribidae-from-east-madagascar-with-images-of-all-madagascan-species-of-the-genus
#14
Miloš Trýzna
A new species Tophoderes banari Trýzna sp. nov. (Anthribidae: Anthribinae: Tophoderini) from east Madagascar is described. Both sexes and male and female genitalia are illustrated. Colour photographs of all Madagascan species of the genus Tophoderes are added.
January 17, 2017: Zootaxa
https://www.readbyqxmd.com/read/28187643/a-new-species-of-i-diastatotropis-i-lacordaire-coleoptera-anthribidae-from-montagne-d-ambre-national-park-northern-madagascar
#15
Miloš Trýzna, Petr Baňař
A new species, Diastatotropis perrinae Trýzna & Baňař sp. nov. (Anthribidae: Anthribinae: Cappadocini), from north Madagascar is described. Male genitalia are studied and illustrated and colour photographs are added. A comparison with the most similar known species, D. tigrinus Lacordaire, 1866, is provided.
January 20, 2017: Zootaxa
https://www.readbyqxmd.com/read/28187540/two-new-species-of-i-adapterops-i-coleoptera-anthribidae-from-protected-areas-of-northern-madagascar-with-a-key-to-species-and-new-faunistic-data-on-the-genus
#16
Miloš Trýzna, Petr Baňař
Two new species, Adapterops mamyi Trýzna & Baňař sp. nov. and A. dimbyi Trýzna & Baňař sp. nov. (Anthribidae: Choraginae: Araecerini), from northern Madagascar are described and illustrated. A key to the species of the genus Adapterops Frieser, 2010 is given. New and interesting faunistic records of the genus are provided. Male terminalia are described for the first time, tegminal process is reported as a unique feature within the family.
February 9, 2017: Zootaxa
https://www.readbyqxmd.com/read/28185773/association-of-gene-polymorphisms-in-interleukin-6-in-infantile-bronchial-asthma
#17
Eva Babusikova, Jana Jurecekova, Milos Jesenak, Andrea Evinova
INTRODUCTION: The genetic background of bronchial asthma is complex, and it is likely that multiple genes contribute to its development both directly and through gene-gene interactions. Cytokines contribute to different aspects of asthma, as they determine the type, severity and outcomes of asthma pathogenesis. Allergic asthmatics undergoing an asthmatic attack exhibit significantly higher levels of pro-inflammatory cytokines, such as interleukins and chemokines. In recent years, cytokines and their receptors have been shown to be highly polymorphic, and this prompted us to investigate interleukin 6 promoter polymorphisms at position -174G/C (rs1800795) and at -572G/C (rs1800796) in relation to asthma in children...
February 6, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28183542/impact-of-ejection-fraction-on-infectious-renal-and-respiratory-morbidity-for-patients-undergoing-noncardiac-surgery
#18
Michael D Maile, William F Armstrong, Elizabeth S Jewell, Milo C Engoren
OBJECTIVE: We sought to determine if decreased left ventricular systolic function was associated with an increased risk of postoperative infectious, respiratory, or renal complications in patients undergoing noncardiac surgery. DESIGN: Retrospective cohort study. SETTING: Single tertiary-care, university-based medical center. PATIENTS: We studied individuals who participated in the American College of Surgeons National Quality Improvement Program and had a preoperative echocardiogram conducted at our institution...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28181313/bright-room-temperature-single-photon-emission-from-defects-in-gallium-nitride
#19
Amanuel M Berhane, Kwang-Yong Jeong, Zoltán Bodrog, Saskia Fiedler, Tim Schröder, Noelia Vico Triviño, Tomás Palacios, Adam Gali, Milos Toth, Dirk Englund, Igor Aharonovich
Room-temperature quantum emitters in gallium nitride (GaN) are reported. The emitters originate from cubic inclusions in hexagonal lattice and exhibit narrowband luminescence in the red spectral range. The sources are found in different GaN substrates, and therefore are promising for scalable quantum technologies.
February 9, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28179104/variations-in-structure-of-the-outflow-tract-of-the-human-embryonic-heart-a-new-hypothesis-for-generating-bicuspid-aortic-semilunar-valves
#20
Nadine C Milos, Derek B Nordstrom, Ivano Ongaro, Ava K Chow
Outflow tract development of the heart is complex. The presence, differential growth and interactions of the various tissues through space and time contribute to the final development of the tract. This paper presents a novel interpretation of observations of outflow tract development, in particular of the aortic and pulmonary semilunar valves in embryos from the Shaner Collection at the University of Alberta. Three-dimensional reconstructions assist in the visualization of the spatial relationships of the developing valve tissues...
February 4, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
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