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https://www.readbyqxmd.com/read/28822348/risk-factors-for-potential-drug-drug-interactions-in-intensive-care-unit-patients
#1
Slobodan M Janković, Ana V Pejčić, Miloš N Milosavljević, Valentina D Opančina, Nikola V Pešić, Tamara T Nedeljković, Goran M Babić
PURPOSE: To determine risk factors for each severity-based category of potential drug-drug interactions (DDIs) encountered at intensive care unit (ICU) patients. METHODS: This was a retrospective cohort analysis of patients treated at the ICU of the Clinical Center Kragujevac, a public tertiary care hospital in Kragujevac, Serbia. Three interaction checkers were used to reveal drug-drug interactions: Medscape, Epocrates and Micromedex. RESULTS: The study included 201 patients, 66...
August 14, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28815601/antimicrobial-synergism-and-cytotoxic-properties-of-citrus-limon-l-piper-nigrum-l-and-melaleuca-alternifolia-maiden-and-betche-cheel-essential-oils
#2
Miloš M Nikolić, Katarina K Jovanović, Tatjana Lj Marković, Dejan Lj Marković, Nevenka N Gligorijević, Siniša S Radulović, Marina Kostić, Jasmina M Glamočlija, Marina D Soković
OBJECTIVES: The chemical composition, antimicrobial and synergistic effect, and cytotoxic activity of Citrus limon (lemon), Piper nigrum (green pepper) and Melaleuca alternifoila (tea tree) essential oils (EOs) were investigated. METHODS: Chemical analyses of essential oils were tested by GC-FID and GC-MS spectroscopy. The antimicrobial activity assay was conducted using microdilution method against several oral bacteria and Candida spp. originating from the humans with oral disorders...
August 17, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28809878/partially-coherent-sources-with-circular-coherence-comment
#3
Milo W Hyde, Santasri R Bose-Pillai
In [Opt. Lett.42, 1512 (2017)OPLEDP0146-959210.1364/OL.42.001512], the authors present a new class of non-uniformly correlated sources with circular coherence. They also describe a basic experimental setup for synthesizing this class of sources, which uses the Van Cittert-Zernike theorem. Here, we present an alternative way to analyze these sources and a different way to generate them.
August 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28809765/cyclin-dependent-kinase-5-modulates-the-p2x2a-receptor-channel-gating-through-phosphorylation-of-c-terminal-threonine-372
#4
Claudio Coddou, Rodrigo Sandoval, Patricio Castro, Pablo Lazcano, Maria José Hevia, Milos Rokic, Bradford Hall, Anita Terse, Christian Gonzalez-Billault, Ashok B Kulkarni, Stanko S Stojilkovic, Elias Utreras
The purinergic P2X2 receptor (P2X2R) is an adenosine triphosphate-gated ion channel widely expressed in the nervous system. Here, we identified a putative cyclin-dependent kinase 5 (Cdk5) phosphorylation site in the full-size variant P2X2aR (TPKH), which is absent in the splice variant P2X2bR. We therefore investigated the effects of Cdk5 and its neuronal activator, p35, on P2X2aR function. We found an interaction between P2X2aR and Cdk5/p35 by co-immunofluorescence and co-immunoprecipitation in HEK293 cells...
July 17, 2017: Pain
https://www.readbyqxmd.com/read/28803486/daclizumab-for-the-treatment-of-adults-with-relapsing-forms-of-multiple-sclerosis
#5
Michael Osherov, Ron Milo
The goal of the article is to review the mechanism of action and the use of daclizumab, a humanized monoclonal antibody (mAb) against the alpha subunit of the high affinity interleukin-2 (IL-2) receptor, in the treatment of Multiple Sclerosis (MS). Areas covered: PubMed was searched for the terms "daclizumab" and "multiple sclerosis". The mechanisms of action, pharmacokinetics and pharmacodynamics, major studies, side effects and drug interactions of daclizumab in MS are discussed. Expert commentary: Monthly daclizumab-beta [DAC-beta, formerly daclizumab high yield process (DAC HYP), approved as ZINBRYTA®, which has a different form and structure than an earlier form of daclizumab], is an effective and convenient treatment option for patients with relapsing forms of MS who have failed other treatment, or as a first-line option in highly active MS patients...
August 14, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28795172/change-point-detection-method-for-clinical-decision-support-system-rule-monitoring
#6
Siqi Liu, Adam Wright, Milos Hauskrecht
A clinical decision support system (CDSS) and its components can malfunction due to various reasons. Monitoring the system and detecting its malfunctions can help one to avoid any potential mistakes and associated costs. In this paper, we investigate the problem of detecting changes in the CDSS operation, in particular its monitoring and alerting subsystem, by monitoring its rule firing counts. The detection should be performed online, that is whenever a new datum arrives, we want to have a score indicating how likely there is a change in the system...
June 2017: Artif Intell Med (2017)
https://www.readbyqxmd.com/read/28795133/performance-of-18-f-flutemetamol-amyloid-imaging-against-the-neuritic-plaque-component-of-cerad-and-the-current-2012-nia-aa-recommendations-for-the-neuropathologic-diagnosis-of-alzheimer-s-disease
#7
Stephen Salloway, Jose E Gamez, Upinder Singh, Carl H Sadowsky, Teresa Villena, Marwan N Sabbagh, Thomas G Beach, Ranjan Duara, Adam S Fleisher, Kirk A Frey, Zuzana Walker, Arvinder Hunjan, Yavir M Escovar, Marc E Agronin, Joel Ross, Andrea Bozoki, Mary Akinola, Jiong Shi, Rik Vandenberghe, Milos D Ikonomovic, Paul F Sherwin, Gill Farrar, Adrian P L Smith, Christopher J Buckley, Dietmar Rudolf Thal, Michelle Zanette, Craig Curtis
INTRODUCTION: Performance of the amyloid tracer [(18)F]flutemetamol was evaluated against three pathology standard of truth (SoT) measures including neuritic plaques (CERAD "original" and "modified" and the amyloid component of the 2012 NIA-AA guidelines). METHODS: After [(18)F]flutemetamol imaging, 106 end-of-life patients who died underwent postmortem brain examination for amyloid plaque load. Blinded positron emission tomography scan interpretations by five independent electronically trained readers were compared with pathology measures...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28791778/redox-properties-of-transitional-milk-from-mothers-of-preterm-infants
#8
Simeon Minić, Miloš Ješić, Dijana Đurović, Srdjan Miletić, Nikoleta Lugonja, Vesna Marinković, Aleksandra Nikolić-Kokić, Snežana Spasić, Miroslav M Vrvić
AIM: There is a discrepancy between the amount of transitional milk produced by mothers of preterm infants and the low capacity of premature infants to consume it. This milk can be used in milk banks, but previous studies found that there are large variations in the level of host-defence proteins in individual samples of milk from mothers of premature infants, which implies that large individual variations in antioxidative defence composition are also possible. METHODS: Milk samples were collected from 20 healthy mothers of preterm infants...
August 9, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28791280/oxidative-stress-and-bronchial-asthma-in-children-causes-or-consequences
#9
REVIEW
Milos Jesenak, Maria Zelieskova, Eva Babusikova
Bronchial asthma is one of the most common chronic inflammatory diseases of the airways. In the pathogenesis of this disease, the interplay among the genes, intrinsic, and extrinsic factors are crucial. Various combinations of the involved factors determine and modify the final clinical phenotype/endotype of asthma. Oxidative stress results from an imbalance between the production of reactive oxygen species and reactive nitrogen species and the capacity of antioxidant defense mechanisms. It was shown that oxidative damage of biomolecules is strongly involved in the asthmatic inflammation...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28771123/pedobacter-psychrophilus-sp-nov-isolated-from-fragmentary-rock
#10
Pavel Švec, Stanislava Králová, Hans-Jürgen Busse, Tanita Kleinhagauer, Kamila Kýrová, Roman Pantůček, Ivana Mašlaňová, Eva Staňková, Miroslav Němec, Pavla Holochová, Miloš Barták, Ivo Sedláček
Strain P4487AT was isolated during investigation of cultivable bacterial populations of environmental materials sampled at James Ross Island, Antarctica. It revealed Gram-stain-negative short rod-shaped cells producing a pink pigment. Phylogenetic analysis based on 16S rRNA gene sequences allocated strain P4487AT to the genus Pedobacter but showed that the strain represents a distinct intrageneric phylogenetic lineage clearly separated from remaining Pedobacter species. Phylogenetically, strain P4487AT formed a common branch with the Pedobacter arcticus and Pedobacter lignilitoris cluster while the highest value of 94...
August 4, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28769101/allostimulatory-capacity-of-conditionally-immortalized-proximal-tubule-cell-lines-for-bioartificial-kidney-application
#11
Milos Mihajlovic, Lambertus P van den Heuvel, Joost G Hoenderop, Jitske Jansen, Martijn J Wilmer, Annemarie J F Westheim, Wil A Allebes, Dimitrios Stamatialis, Luuk B Hilbrands, Rosalinde Masereeuw
Novel renal replacement therapies, such as a bioartificial kidney (BAK), are needed to improve current hemodialysis treatment of end-stage renal disease (ESRD) patients. As BAK applications may reveal safety concerns, we assessed the alloimmunization and related safety aspects of readily available conditionally immortalized human proximal tubule epithelial cell (ciPTEC) lines to be used in BAK. Two ciPTEC lines, originally derived from urine and kidney tissue, were characterized for the expression and secretion of relevant molecules involved in alloimmunization and inflammatory responses, such as HLA class-I, HLA-DR, CD40, CD80, CD86, as wells as soluble HLA class I and proinflammatory cytokines (IL-6, IL-8 and TNF-α)...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28764012/antioxidative-mechanisms-in-chlorogenic-acid
#12
Jelena Tošović, Svetlana Marković, Jasmina M Dimitrić Marković, Miloš Mojović, Dejan Milenković
Although chlorogenic acid (5CQA) is an important ingredient of various foods and beverages, mechanisms of its antioxidative action have not been fully clarified. Besides electron spin resonance experiment, this study includes thermodynamic and mechanistic investigations of the hydrogen atom transfer (HAT), radical adduct formation (RAF), sequential proton loss electron transfer (SPLET), and single electron transfer - proton transfer (SET-PT) mechanisms of 5CQA in benzene, ethanol, and water solutions. The calculations were performed using the M06-2X/6-311++G(d,p) level of theory and CPCM solvation model...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28760606/synthesis-analytical-characterization-and-capillary-electrophoretic-use-of-the-single-isomer-heptakis-6-o-sulfobutyl-beta-cyclodextrin
#13
Milo Malanga, Ida Fejős, Erzsébet Varga, Gábor Benkovics, András Darcsi, Julianna Szemán, Szabolcs Béni
This contribution reports the synthesis, characterization and capillary electrophoretic application of heptakis-(6-O-sulfobutyl-ether)-β-cyclodextrin sodium salt, (6-(SB)7-β-CD). The compound was obtained through a five-steps synthesis and it represents the first example of single-isomer sulfobutylated cyclodextrin that carries the negatively charged functions exclusively on its primary side and it is unmodified on the lower rim. The purity of each intermediate was determined by appropriate liquid chromatographic methods, while the isomeric purity of the final product was established by an ad-hoc developed HPLC method based on a CD-Screen-IEC column...
July 21, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28758151/the-effect-of-diet-induced-serum-hypercholesterolemia-on-the-surfactant-system-and-the-development-of-lung-injury
#14
Scott Milos, Joshua Qua Hiansen, Brandon Banaschewski, Yi Y Zuo, Li-Juan Yao, Lynda A McCaig, James Lewis, Cory M Yamashita, Ruud A W Veldhuizen
Acute respiratory distress syndrome (ARDS) is a pulmonary disorder associated with alterations to the pulmonary surfactant system. Recent studies showed that supra-physiological levels of cholesterol in surfactant contribute to impaired function. Since cholesterol is incorporated into surfactant within the alveolar type II cells which derives its cholesterol from serum, it was hypothesized that serum hypercholesterolemia would predispose the host to the development of lung injury due to alterations of cholesterol content in the surfactant system...
September 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28751484/medication-incidents-in-primary-care-medicine-a-prospective-study-in-the-swiss-sentinel-surveillance-network-sentinella
#15
Markus Gnädinger, Dieter Conen, Lilli Herzig, Milo A Puhan, Alfred Staehelin, Marco Zoller, Alessandro Ceschi
OBJECTIVES: To describe the type, frequency, seasonal and regional distribution of medication incidents in primary care in Switzerland and to elucidate possible risk factors for medication incidents. DESIGN: Prospective surveillance study. SETTING: Swiss primary healthcare, Swiss Sentinel Surveillance Network. PARTICIPANTS: Patients with drug treatment who experienced any erroneous event related to the medication process and interfering with normal treatment course, as judged by their physician...
July 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/28745622/a-graphical-user-interface-for-software-assisted-tracking-of-protein-concentration-in-dynamic-cellular-protrusions
#16
Tanumoy Saha, Isabel Rathmann, Milos Galic
Filopodia are dynamic, finger-like cellular protrusions associated with migration and cell-cell communication. In order to better understand the complex signaling mechanisms underlying filopodial initiation, elongation and subsequent stabilization or retraction, it is crucial to determine the spatio-temporal protein activity in these dynamic structures. To analyze protein function in filopodia, we recently developed a semi-automated tracking algorithm that adapts to filopodial shape-changes, thus allowing parallel analysis of protrusion dynamics and relative protein concentration along the whole filopodial length...
July 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28739618/atypical-presentation-of-parsonage-turner-syndrome-confounded-by-surgical-rotator-cuff-injury
#17
Dustin Adam Greenhill, Hesham Abdelfattah, Joseph S Torg, Joseph Milo Sewards
Parsonage-Turner syndrome (PTS) is a rare neuropathy that commonly presents as unexpected severe shoulder and arm pain that eventually subsides while weakness or paralysis ensues. During exceptions to this classic presentation, confirming PTS can be challenging. Alternative causes of upper extremity pain may confound the diagnostic algorithm. Moreover, objective findings from necessary diagnostic tests depend on when those tests are performed. We present an atypical onset of PTS, whereby the initial presentation of severe neuropathic pain was preceded by mild shoulder pain that should decrease one's clinical suspicion for PTS...
July 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28737479/evaluation-of-brivaracetam-a-new-drug-to-treat-epilepsy
#18
Jasmina R Milovanović, Slobodan M Janković, Ana Pejčić, Miloš Milosavljević, Valentina Opančina, Vesela Radonjić, Zoran Protrka, Marina Kostić
High prevalence of therapy-resistant epilepsy demands development of anticonvulsants with new mechanisms of action. Brivaracetam is an analogue of levetiracetam which binds to the synaptic vesicle protein 2A (SV2A) and decreases release of excitatory neurotransmitters. Areas covered: Relevant published studies were searched for by predefined strategy in MEDLINE, EBSCO and SCINDEKS electronic databases. Brivaracetam is effective as adjunctive therapy for uncontrolled partial-onset seizures with or without secondary generalization in patients 16 years and older with epilepsy...
July 28, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28734171/muscle-synergies-reveal-impaired-trunk-muscle-coordination-strategies-in-individuals-with-thoracic-spinal-cord-injury
#19
Matija Milosevic, Hikaru Yokoyama, Murielle Grangeon, Kei Masani, Milos R Popovic, Kimitaka Nakazawa, Dany H Gagnon
Spinal cord injury (SCI) can result in paralysis of trunk muscles, which can affect sitting balance. The objective of this study was to analyze trunk muscle coordination of individuals with thoracic SCI and compare it to able-body individuals. A total of 27 individuals were recruited and subdivided into: (a) high thoracic SCI; (b) low thoracic SCI; and (c) able-body groups. Participants were seated and asked to lean their trunk in eight directions while trunk muscle activity was recorded. Muscle coordination was assessed using the non-negative matrix factorization (NMF) method to extract muscle modules, which are the synergistic trunk muscle activations, and their directional activation patterns...
July 1, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28734107/extended-release-naltrexone-for-methamphetamine-dependence-among-men-who-have-sex-with-men-a-randomized-placebo-controlled-trial
#20
Phillip O Coffin, Glenn-Milo Santos, Jaclyn Hern, Eric Vittinghoff, Deirdre Santos, Tim Matheson, Grant Colfax, Steven L Batki
BACKGROUND AND AIMS: Methamphetamine use is increasingly prevalent and associated with HIV transmission. Early phase human studies suggested naltrexone reduced amphetamine use among dependent individuals. We tested if extended-release naltrexone (XRNTX) reduces methamphetamine use and associated sexual risk behaviors among high-risk methamphetamine-dependent men who have sex with men (MSM). DESIGN: Double-blind, placebo-controlled, randomized trial of XRTNX versus placebo over 12 weeks from 2012-2015...
July 22, 2017: Addiction
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