Read by QxMD icon Read


Thomas A Schwann, Robert H Habib, Amelia Wallace, David M Shahian, Sean O'Brien, Jeffery P Jacobs, John D Puskas, Paul A Kurlansky, Milo C Engoren, Robert F Tranbaugh, Mark R Bonnell
BACKGROUND: More than 90% of coronary artery bypass grafting (CABG) is performed with a single-arterial bypass graft (SABG), based on the left internal thoracic artery (ITA) with supplemental vein grafts. This practice, often justified by safety concerns with multiple-arterial grafting (MABG), defies evidence of improved late survival achieved with bilateral ITA (BITA-MABG) or left ITA plus radial artery (RA-MABG). We hypothesized that MABG and SABG are equally safe. METHODS: We analyzed The Society of Thoracic Surgeons National Database (2004 to 2015) to assess the operative safety of BITA-MABG (n = 73,054) and RA-MABG (n = 97,623) vs SABG (n = 1,334,511)...
February 13, 2018: Annals of Thoracic Surgery
Antonia Kotianova, Michal Kotian, Milos Slepecky, Michaela Chupacova, Jan Prasko, Ingrid Tonhajzerova
Background: Alarming somatic symptoms, in particular, cardiovascular symptoms, are the characteristic feature of panic attacks. Increased cardiac mortality and morbidity have been found in these patients. Power spectral analysis of electrocardiogram R-R intervals is known to be a particularly successful tool in the detection of autonomic instabilities in various clinical disorders. Our study aimed to compare patients with panic disorder and healthy controls in heart rate variation (HRV) parameters (very-low-frequency [VLF], low-frequency [LF], and high-frequency [HF] band components of R-R interval) in baseline and during the response to the mental task...
2018: Neuropsychiatric Disease and Treatment
Scarlet Milo, Florianne B Acosta, Hollie J Hathaway, Laura A Wallace, Naing T Thet, A Toby A Jenkins
Formation of crystalline biofilms following infection by Proteus mirabilis can lead to encrustation and blockage of long-term indwelling catheters, with serious clinical consequences. We describe a simple sensor, placed within the catheter drainage bag, to alert of impending blockage via a urinary color change. The pH-responsive sensor is a dual-layered polymeric "lozenge", able to release the self-quenching dye 5(6)-carboxyfluorescein in response to the alkaline urine generated by the expression of bacterial urease...
February 14, 2018: ACS Sensors
Sejeong Kim, Milos Toth, Igor Aharonovich
We propose and design photonic crystal cavities (PCCs) in hexagonal boron nitride (hBN) for diverse photonic and quantum applications. Two dimensional (2D) hBN flakes contain quantum emitters which are ultra-bright and photostable at room temperature. To achieve optimal coupling of these emitters to optical resonators, fabrication of cavities from hBN is therefore required to maximize the overlap between cavity optical modes and the emitters. Here, we design 2D and 1D PCCs using anisotropic indices of hBN. The influence of underlying substrates and material absorption are investigated, and spontaneous emission rate enhancements are calculated...
2018: Beilstein Journal of Nanotechnology
Francois De Luca, Giorgio Sernicola, Milo S P Shaffer, Alexander Bismarck
The fiber-matrix interface plays a critical role in determining composite mechanical properties. While a strong interface tends to provide high strength, a weak interface enables extensive debonding, leading to a high degree of energy absorption. Balancing these conflicting requirements by engineering composite interfaces to improve strength and toughness simultaneously still remains a great challenge. Here, a nanostructured fiber coating was realized to manifest the critical characteristics of natural nacre, at a reduced length scale, consistent with the surface curvature of fibers...
February 13, 2018: ACS Applied Materials & Interfaces
Sarah R Haile, Beniamino Guerra, Joan B Soriano, Milo A Puhan
Following publication of the original article [1], a member of the writing group reported that his name is misspelt. The paper should appear in Pubmed under "Ter Riet G", bot as "Riet GT".
February 12, 2018: BMC Medical Research Methodology
Kerem Bray, Hiromitsu Kato, Rodolfo Previdi, Russell Sandstrom, Kumaravelu Ganesan, Masahiko Ogura, Toshiharu Makino, Satoshi Yamasaki, Andrew P Magyar, Milos Toth, Igor Aharonovich
Single crystal, nanoscale diamond membranes are highly sought after for a variety of applications including nanophotonics, nanoelectronics and quantum information science. However, so far, the availability of conductive diamond membranes has remained an unreachable goal. In this work we present a complete nanofabrication methodology for engineering high aspect ratio, electrically active single crystal diamond membranes. The membranes have large lateral directions, exceeding ∼500 × 500 μm2 and are only several hundreds of nanometers thick...
February 12, 2018: Nanoscale
Dominik R Brkić, Aleksandra R Božić, Aleksandar D Marinković, Miloš K Milčić, Nevena Ž Prlainović, Fathi H Assaleh, Ilija N Cvijetić, Jasmina B Nikolić, Saša Ž Drmanić
The ratios of E/Z isomers of sixteen synthesized 1,3-dihydro-3-(substituted phenylimino)-2H-indol-2-one were studied using experimental and theoretical methodology. Linear solvation energy relationships (LSER) rationalized solvent influence of the solvent-solute interactions on the UV-Vis absorption maxima shifts (νmax) of both geometrical isomers using the Kamlet-Taft equation. Linear free energy relationships (LFER) in the form of single substituent parameter equation (SSP) was used to analyze substituent effect on pKa, NMR chemical shifts and νmax values...
February 2, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Alvaro García-Guerra, Aurea M O Canavessi, Pedro L J Monteiro Jr, Megan A Mezera, Roberto Sartori, Brian W Kirkpatrick, Milo C Wiltbank
The acquisition of dominance and ovulatory capacity was evaluated in follicles from cows that were carriers or half-sibling non-carriers of the Trio allele. Follicle size at acquisition of follicular dominance was determined by evaluating whether follicles ovulate after GnRH challenge (ovulatory capacity-experiment 1) and by determination of intra-follicular concentrations of estradiol and free IGF1 and relative mRNA expression of CYP19A1, LHCGR, and PAPPA in granulosa cells from follicles of different sizes (experiment 2)...
February 7, 2018: Biology of Reproduction
Alvaro Garcia-Guerra, Mamat H Kamalludin, Brian W Kirkpatrick, Milo C Wiltbank
The newly-discovered Trio high-fecundity allele produces multiple ovulations in cattle. The present study evaluated: 1) Size and growth rates of follicles in Trio carriers during a synchronized follicular wave, induced by follicle aspiration, 2) FSH patterns associated with the follicular wave, 3) Size of corpora lutea (CL) and circulating progesterone, and 4) Intra-follicular estradiol concentrations prior to normal deviation. Trio carriers had mean dominant follicles that were significantly smaller in diameter and volume than non-carriers...
February 7, 2018: Biology of Reproduction
Safa Shehab, Crystal D'souza, Milos Ljubisavljevic, Peter Redgrave
Deep Brain Stimulation applied at high frequency (HFS) to the subthalamic nucleus (STN) is used to ameliorate the symptoms of Parkinson's disease. The mechanism by which this is achieved remains controversial. In particular, it is uncertain whether HFS has a suppressive or excitatory action locally within the STN. Brief exposure of rats to ether anaesthesia evokes pathological burst firing and associated expression of the immediate early gene c-Fos in STN neurons. We used this ether model of STN activation to test the effect of a range of HFS parameters on c-Fos expression evoked by the anesthetic...
February 5, 2018: Brain Research
Miloš Vittori, Mohammed Khurshed, Daisy I Picavet, Cornelis J F van Noorden, Jasna Štrus
Calcium bodies are internal epithelial sacs found in terrestrial isopods of the family Trichoniscidae that contain a mineralized extracellular matrix that is deposited and resorbed in relation to the molt cycle. Calcium bodies in several trichoniscids are filled with bacteria, the function of which is currently unknown. The woodlouse Hyloniscus riparius differs from other trichoniscids in that it possesses two different pairs of calcium bodies, the posterior pair being filled with bacteria and the anterior pair being devoid of bacteria...
February 5, 2018: Arthropod Structure & Development
Milos Petrovic, Constantinos N Maganaris, Kevin Deschamps, Sabine M Verschueren, Frank L Bowling, Andrew Jm Boulton, Neil D Reeves
The Achilles tendon (AT) has the capacity to store and release elastic energy during walking, contributing to metabolic energy savings. In diabetes patients, it is hypothesised that a stiffer Achilles tendon may reduce the capacity for energy saving through this mechanism, thereby contributing to an increased metabolic cost of walking (CoW). The aim of this study was to investigate the effects of diabetes and diabetic peripheral neuropathy (DPN) on the Achilles tendon and plantarflexor muscle-tendon unit behaviour during walking...
February 8, 2018: Journal of Applied Physiology
Ivana Prodic, Dragana Stanic-Vucinic, Danijela Apostolovic, Jelena Mihailovic, Milica Radibratovic, Jelena Radosavljevic, Lidija Burazer, Milos Milcic, Katarina Smiljanic, Marianne van Hage, Tanja Cirkovic Velickovic
BACKGROUND: Most food allergens sensitizing via the gastrointestinal tract are stable proteins that are resistant to pepsin digestion, in particular major peanut allergens, Ara h 2 and Ara h 6. Survival of their large fragments is essential for sensitizing capacity. However, the immunoreactive proteins/peptides to which the immune system of the gastrointestinal tract is exposed during digestion of peanut proteins is unknown. Particularly, the IgE-reactivity of short digestion-resistant peptides (<10 kDa) released by gastric digestion under standardized and physiologically relevant in vitro conditions has not been investigated...
February 7, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Thomas A Schwann, Abdul Karim M El Hage Sleiman, Maroun B Yammine, Robert F Tranbaugh, Milo Engoren, Mark R Bonnell, Robert H Habib
BACKGROUND: Multi-arterial coronary grafting with two arterial grafts (2-art) leads to improved survival compared to conventional single-arterial (1-art) based on left internal thoracic artery to left anterior descending (LITA-LAD) and saphenous vein grafts. We investigated whether extending arterial grafting to three or more arterial (3-art) grafts further improves survival, and whether such a benefit is modified by diabetes. METHODS: We analyzed fifteen-year CABG mortality data in 11,931 patients [64...
February 2, 2018: Annals of Thoracic Surgery
Yossef Ehrlichman, Anatol Khilo, Miloš A Popović
The efficiency of optical sideband generation with a microring resonator modulator as a function of modulator parameters is studied taking into account the photon dynamics inside the resonator. The best achievable modulation efficiency is determined for any choice of the resonator intrinsic quality factor, and analytic solutions for the optimum modulator parameters, namely the coupling coefficient and the detuning between the frequencies of the input laser light and the microring resonance, are provided. This analysis is carried out both for a narrowband RF signal, in which case the modulator is optimized for the center frequency of this signal, and for wideband signals, when high conversion efficiency over a wide range of RF frequencies is desired...
February 5, 2018: Optics Express
Milo W Hyde, Santasri R Bose-Pillai, Olga Korotkova
This article presents a method to simulate a three-dimensional (3D) electromagnetic Gaussian-Schell model (EGSM) source with desired characteristics. Using the complex screen method, originally developed for the synthesis of two-dimensional stochastic electromagnetic fields, a set of equations is derived which relate the desired 3D source characteristics to those of the statistics of the random complex screen. From these equations and the 3D EGSM source realizability conditions, a single criterion is derived, which when satisfied guarantees both the realizability and simulatability of the desired 3D EGSM source...
February 5, 2018: Optics Express
Cecilia Laterza, Naomi Uoshima, Daniel Tornero, Ulrika Wilhelmsson, Anna Stokowska, Ruimin Ge, Milos Pekny, Olle Lindvall, Zaal Kokaia
Induced pluripotent stem cells (iPSCs) or their progeny, derived from human somatic cells, can give rise to functional improvements after intracerebral transplantation in animal models of stroke. Previous studies have indicated that reactive gliosis, which is associated with stroke, inhibits neurogenesis from both endogenous and grafted neural stem/progenitor cells (NSPCs) of rodent origin. Here we have assessed whether reactive astrocytes affect the fate of human iPSC-derived NSPCs transplanted into stroke-injured brain...
2018: PloS One
Miloš Erak, Kathrin Bellmann-Sickert, Sylvia Els-Heindl, Annette G Beck-Sickinger
The development of solid phase peptide synthesis has released tremendous opportunities for using synthetic peptides in medicinal applications. In the last decades, peptide therapeutics became an emerging market in pharmaceutical industry. The need for synthetic strategies in order to improve peptidic properties, such as longer half-life, higher bioavailability, increased potency and efficiency is accordingly rising. In this mini-review, we present a toolbox of modifications in peptide chemistry for overcoming the main drawbacks during the transition from natural peptides to peptide therapeutics...
January 29, 2018: Bioorganic & Medicinal Chemistry
Pavel Rehulka, Martina Zahradnikova, Helena Rehulkova, Petra Dvorakova, Rudolf Nenutil, Dalibor Valik, Borivoj Vojtesek, Lenka Hernychova, Milos V Novotny
Analysis of N-glycans released enzymatically from patients' sera or other clinical samples may provide diagnostically and prognostically important information in human disease. Permethylation of these biomolecules simultaneously increases their hydrophobicity and substantially improves their detection parameters in the following mass spectrometric analyses. The overall procedure, from the glycan cleavage to the final mass spectrometric determinations, includes several steps involving extraction, derivatization and purification...
February 2, 2018: Journal of Separation Science
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"