keyword
MENU ▼
Read by QxMD icon Read
search

milo

keyword
https://www.readbyqxmd.com/read/29223653/effects-of-cardiac-rehabilitation-on-heart-rate-recovery-of-patients-undergoing-a-cardiac-rehabilitation-programme-after-acute-coronary-syndrome
#1
Tiffany Astolfi, Fabio Borrani, Milos Savcic, Vincent Gremeaux, Grégoire P Millet
BACKGROUND: An efficient cardiac rehabilitation programme (CRP) can improve the functional ability of patients after acute coronary syndrome (ACS). OBJECTIVE: To examine the effect of a CRP on parasympathetic reactivation and heart rate recovery (HRR) measured after a 6-min walk test (6MWT), and correlation with 6MWT distance and well-being after ACS. METHODS: Eleven normoweight patients after ACS (BMI < 25kg/m2; 10 males; mean [SD] age 61 [9] years) underwent an 8-week CRP...
December 6, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29220870/quantitative-assessment-of-informative-immunophenotypic-markers-increases-the-diagnostic-value-of-immunophenotyping-in-mature-cd5-positive-b-cell-neoplasms
#2
Starostka David, Kriegova Eva, Kudelka Milos, Mikula Peter, Zehnalova Sarka, Radvansky Martin, Papajik Tomas, Kolacek David, Chasakova Katerina, Talianova Hana
BACKGROUND: The data on the clinical utility of the quantitative assessment of immunophenotypes in distinguishing mature CD5-positive B-cell neoplasms is limited. The study aim was to assess the diagnostic value of the quantitative assessment of a panel of 18 markers and to identify the most informative ones. METHODS: The immunophenotype of the neoplastic population was determined in diagnostic specimens from 188 patients. BD FACSCanto II flow cytometer and FACSDiva software were used to analyse the positivity/negativity and mean fluorescence intensity (MFI) of the surface expression of 18 markers...
December 8, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29220675/exome-wide-association-study-identifies-greb1l-mutations-in-congenital-kidney-malformations
#3
Simone Sanna-Cherchi, Kamal Khan, Rik Westland, Priya Krithivasan, Lorraine Fievet, Hila Milo Rasouly, Iuliana Ionita-Laza, Valentina P Capone, David A Fasel, Krzysztof Kiryluk, Sitharthan Kamalakaran, Monica Bodria, Edgar A Otto, Matthew G Sampson, Christopher E Gillies, Virginia Vega-Warner, Katarina Vukojevic, Igor Pediaditakis, Gabriel S Makar, Adele Mitrotti, Miguel Verbitsky, Jeremiah Martino, Qingxue Liu, Young-Ji Na, Vinicio Goj, Gianluigi Ardissino, Maddalena Gigante, Loreto Gesualdo, Magdalena Janezcko, Marcin Zaniew, Cathy Lee Mendelsohn, Shirlee Shril, Friedhelm Hildebrandt, Joanna A E van Wijk, Adela Arapovic, Marijan Saraga, Landino Allegri, Claudia Izzi, Francesco Scolari, Velibor Tasic, Gian Marco Ghiggeri, Anna Latos-Bielenska, Anna Materna-Kiryluk, Shrikant Mane, David B Goldstein, Richard P Lifton, Nicholas Katsanis, Erica E Davis, Ali G Gharavi
No abstract text is available yet for this article.
December 7, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29218870/loss-of-function-of-neuroplasticity-related-genes-confers-risk-for-human-neurodevelopmental-disorders
#4
Milo R Smith, Benjamin S Glicksberg, Li Li, Rong Chen, Hirofumi Morishita, Joel T Dudley
High and increasing prevalence of neurodevelopmental disorders place enormous personal and economic burdens on society. Given the growing realization that the roots of neurodevelopmental disorders often lie in early childhood, there is an urgent need to identify childhood risk factors. Neurodevelopment is marked by periods of heightened experience-dependent neuroplasticity wherein neural circuitry is optimized by the environment. If these critical periods are disrupted, development of normal brain function can be permanently altered, leading to neurodevelopmental disorders...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29209134/metabolically-based-liver-damage-pathophysiology-in-patients-with-urea-cycle-disorders-a-new-hypothesis
#5
Ivan Ivanovski, Miloš Ješić, Ana Ivanovski, Livia Garavelli, Petar Ivanovski
The underlying pathophysiology of liver dysfunction in urea cycle disorders (UCDs) is still largely elusive. There is some evidence that the accumulation of urea cycle (UC) intermediates are toxic for hepatocyte mitochondria. It is possible that liver injury is directly caused by the toxicity of ammonia. The rarity of UCDs, the lack of checking of iron level in these patients, superficial knowledge of UC and an underestimation of the metabolic role of fumaric acid, are the main reasons that are responsible for the incomprehension of the mechanism of liver injury in patients suffering from UCDs...
November 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29209109/resveratrol-modifies-biliary-secretion-of-cholephilic-compounds-in-sham-operated-and-cholestatic-rats
#6
Eva Dolezelova, Alena Prasnicka, Jolana Cermanova, Alejandro Carazo, Lucie Hyrsova, Milos Hroch, Jaroslav Mokry, Michaela Adamcova, Alena Mrkvicova, Petr Pavek, Stanislav Micuda
AIM: To investigate the effect of resveratrol on biliary secretion of cholephilic compounds in healthy and bile duct-obstructed rats. METHODS: Resveratrol (RSV) or saline were administered to rats by daily oral gavage for 28 d after sham operation or reversible bile duct obstruction (BDO). Bile was collected 24 h after the last gavage during an intravenous bolus dose of the Mdr1/Mrp2 substrate azithromycin. Bile acids, glutathione and azithromycin were measured in bile to quantify their level of biliary secretion...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29203916/a-model-for-sustainable-us-beef-production
#7
Gidon Eshel, Alon Shepon, Taga Shaket, Brett D Cotler, Stav Gilutz, Daniel Giddings, Maureen E Raymo, Ron Milo
Food production dominates land, water and fertilizer use and is a greenhouse gas source. In the United States, beef production is the main agricultural resource user overall, as well as per kcal or g of protein. Here, we offer a possible, non-unique, definition of 'sustainable' beef as that subsisting exclusively on grass and by-products, and quantify its expected US production as a function of pastureland use. Assuming today's pastureland characteristics, all of the pastureland that US beef currently use can sustainably deliver ≈45% of current production...
December 4, 2017: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29201360/are-physician-assistant-and-patient-airway-assessments-reliable-compared-to-anesthesiologist-assessments-in-detecting-difficult-airways-in-general-surgical-patients
#8
Erin Payne, Jacqueline Ragheb, Elizabeth S Jewell, Betsy P Huang, Angela M Bailey, Laura M Fritsch, Milo Engoren
Background: Airway management remains one of the most important responsibilities of anesthesiologists. Prediction of difficult airway allows time for proper selection of equipment, technique, and personnel experienced in managing patients with difficult airway. Face to face preoperative anesthesia interviews are difficult to conduct as they necessitate patients traveling to the clinics, and, in practice, are usually conducted in the morning of the procedure by the anesthesiologist, when identification of predictors of difficult intubation may lead to schedule delays or case cancelations...
2017: Perioperative Medicine
https://www.readbyqxmd.com/read/29195570/worldwide-trends-in-multi-arterial-coronary-artery-bypass-grafting-surgery-2004-2014-a-tale-of-2-continents
#9
Thomas A Schwann, James Tatoulis, John Puskas, Mark Bonnell, David Taggart, Paul Kurlansky, Jeffery P Jacobs, Vinod H Thourani, Sean O'Brien, Amelia Wallace, Milo C Engoren, Robert F Tranbaugh, Robert H Habib
Recent evidence shows that multi-arterial coronary artery bypass grafting (MABG) based on bilateral internal thoracic (BITA) or left internal thoracic (LITA) and radial artery (RA) improves long-term outcomes compared with single arterial coronary artery bypass grafting (SABG) (LITA + saphenous vein graft). How this evidence affected the worldwide use of MABG, if at all, is not well defined. Accordingly, we report 10-year temporal trends of MABG utilization from 2 continents. A study population of 1,683,434 non-emergent, primary, isolated LITA-based coronary artery bypass grafting (CABG) (≥2 grafts) patients was derived from the Society of Thoracic Surgeons (STS) (1,307,528 (79...
2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29191357/patient-specific-evolution-of-renal-function-in-chronic-heart-failure-patients-dynamically-predicts-clinical-outcome-in-the-bio-shift-study
#10
Milos Brankovic, K Martijn Akkerhuis, Nick van Boven, Sharda Anroedh, Alina Constantinescu, Kadir Caliskan, Olivier Manintveld, Jan Hein Cornel, Sara Baart, Dimitris Rizopoulos, Hans Hillege, Eric Boersma, Victor Umans, Isabella Kardys
Renal dysfunction is an important component of chronic heart failure (CHF), but its single assessment does not sufficiently reflect clinically silent progression of CHF prior to adverse clinical outcome. Therefore, we aimed to investigate temporal evolutions of glomerular and tubular markers in 263 stable patients with CHF, and to determine if their patient-specific evolutions during this clinically silent period can dynamically predict clinical outcome. We determined the risk of clinical outcome (composite endpoint of Heart Failure hospitalization, cardiac death, Left Ventricular Assist Device placement, and heart transplantation) in relation to marker levels, slopes and areas under their trajectories...
November 28, 2017: Kidney International
https://www.readbyqxmd.com/read/29191247/the-implication-of-the-shortage-of-health-workforce-specialist-on-universal-health-coverage-in-kenya
#11
Mumbo Hazel Miseda, Samuel Odhiambo Were, Cirindi Anne Murianki, Milo Peter Mutuku, Stephen N Mutwiwa
BACKGROUND: Globally, there is an acute shortage of human resources for health (HRH), and the greatest burden is borne by low-income countries especially in sub-Saharan Africa and some parts of Asia. This shortage has not only considerably constrained the achievement of health-related development goals but also impeded accelerated progress towards universal health coverage (UHC). Like any other low-income country, Kenya is experiencing health workforce shortage particularly in specialized healthcare workers to cater for the rapidly growing need for specialized health care (MOH Training Needs Assessment report (2015))...
December 1, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/29187788/scolytinae-in-hazelnut-orchards-of-turkey-clarification-of-species-and-identification-key-coleoptera-curculionidae
#12
Celal Tuncer, Milos Knizek, Juri Hulcr
Hazelnut, a very important cash crop in Turkey, is frequently colonized by bark and ambrosia beetle species (Scolytinae). Some scolytine species may cause economic damage while other species do not; therefore, proper identification is important in orchard management. Extensive sampling demonstrated that the most common pest species in Turkey's hazelnut orchards are Anisandrus dispar, Xylosandrus germanus, and Xyleborinus saxesenii. Hypothenemus eruditus can also be common, but only colonizes branches that are already dead...
2017: ZooKeys
https://www.readbyqxmd.com/read/29187479/predictive-significance-of-thymidylate-synthase-expression-in-non-small-cell-lung-cancer
#13
Vlastimil Kulda, Kristyna Hrda, Zbynek Houdek, Jana Kolaja Dobra, Radana Vrzakova, Martin Svaton, Jarmil Safranek, Jan Dolezal, Vaclav Babuska, Milos Pesek, Ondrej Topolcan, Martin Pesta
BACKGROUND/AIM: To date, many studies have suggested that thymidylate synthase (TS) could be used as a prognostic and predictive marker in non-small cell lung cancer (NSCLC) patients. However, results have been contradictory. The aim of this study was to evaluate TS mRNA levels in tumor tissue of NSCLC patients who underwent complete surgical resection and to analyze its prognostic and predictive potential. MATERIALS AND METHODS: The study group consisted of 64 patients who underwent curative lung resection...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29186865/role-of-vitamin-d-in-maintaining-renal-epithelial-barrier-function-in-uremic-conditions
#14
Milos Mihajlovic, Michele Fedecostante, Miriam J Oost, Sonja K P Steenhuis, Eef G W M Lentjes, Inge Maitimu-Smeele, Manoe J Janssen, Luuk B Hilbrands, Rosalinde Masereeuw
As current kidney replacement therapies are not efficient enough for end-stage renal disease (ESRD) treatment, a bioartificial kidney (BAK) device, based on conditionally immortalized human proximal tubule epithelial cells (ciPTEC), could represent an attractive solution. The active transport activity of such a system was recently demonstrated. In addition, endocrine functions of the cells, such as vitamin D activation, are relevant. The organic anion transporter 1 (OAT-1) overexpressing ciPTEC line presented 1α-hydroxylase (CYP27B1), 24-hydroxylase (CYP24A1) and vitamin D receptor (VDR), responsible for vitamin D activation, degradation and function, respectively...
November 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29184111/non-invasive-and-invasive-diagnoses-of-aspergillosis-in-a-rat-model-by-mass-spectrometry
#15
Dominika Luptáková, Tomáš Pluháček, Miloš Petřík, Jiří Novák, Andrea Palyzová, Lucie Sokolová, Anton Škríba, Blanka Šedivá, Karel Lemr, Vladimír Havlíček
Invasive pulmonary aspergillosis results in 450,000 deaths per year and complicates cancer chemotherapy, transplantations and the treatment of other immunosuppressed patients. Using a rat model of experimental aspergillosis, the fungal siderophores ferricrocin and triacetylfusarinine C were identified as markers of aspergillosis and quantified in urine, serum and lung tissues. Biomarkers were analyzed by matrix-assisted laser desorption ionization (MALDI) and electrospray ionization mass spectrometry using a 12T SolariX Fourier transform ion cyclotron resonance (FTICR) mass spectrometer...
November 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29181976/effect-of-low-temperature-on-charge-transport-in-operational-planar-and-mesoporous-perovskite-solar-cells
#16
Miloš Petrović, Tao Ye, Vijila Chellappan, Seeram Ramakrishna
Low-temperature optoelectrical studies of perovskite solar cells using MAPbI3 and mixed-perovskite absorbers implemented into planar and mesoporous architectures reveal fundamental charge transporting properties in fully assembled devices operating under light bias. Both types of devices exhibit inverse correlation of charge carrier lifetime as a function of temperature, extending carrier lifetimes upon temperature reduction, especially after exposure to high optical biases. Contribution of bimolecular channels to overall recombination process should not be overlooked, since the density of generated charge surpasses trap-filling concentration requirements...
November 28, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29173819/bleb-expansion-in-migrating-cells-depends-on-supply-of-membrane-from-cell-surface-invaginations
#17
Mohammad Goudarzi, Katsiaryna Tarbashevich, Karina Mildner, Isabell Begemann, Jamie Garcia, Azadeh Paksa, Michal Reichman-Fried, Harsha Mahabaleshwar, Heiko Blaser, Johannes Hartwig, Dagmar Zeuschner, Milos Galic, Michel Bagnat, Timo Betz, Erez Raz
Cell migration is essential for morphogenesis, organ formation, and homeostasis, with relevance for clinical conditions. The migration of primordial germ cells (PGCs) is a useful model for studying this process in the context of the developing embryo. Zebrafish PGC migration depends on the formation of cellular protrusions in form of blebs, a type of protrusion found in various cell types. Here we report on the mechanisms allowing the inflation of the membrane during bleb formation. We show that the rapid expansion of the protrusion depends on membrane invaginations that are localized preferentially at the cell front...
November 21, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29172484/insulin-like-growth-factor-1-analogs-clicked-in-the-c-domain-chemical-synthesis-and-biological-activities
#18
Katerina Machackova, Michaela Collinsová, Martina Chrudinová, Irena Selicharová, Jan Picha, Miloš Buděšínský, Vaclav Vanek, Lenka Zakova, Andrzej Marek Brzozowski, Jiri Jiracek
Human insulin-like growth factor 1 (IGF-1) is a 70-amino acid protein hormone, with key impact on growth, development and lifespan. The physiological and clinical importance of IGF-1 prompted challenging chemical and biological trials towards the development of its analogs as molecular tools for the IGF-1 receptor (IGF1-R) studies, and as new therapeutics. Here, we report a new method for the total chemical synthesis of IGF-1 analogs, which entails the solid-phase synthesis of two IGF-1 precursor chains that is followed by the CuI-catalyzed azide-alkyne cycloaddition ligation, and by biomimetic formation of a native pattern of disulfides...
November 27, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29171602/the-benchmark-of-31-p-nmr-parameters-in-phosphate-a-case-study-on-structurally-constrained-and-flexible-phosphate
#19
Jiří Fukal, Ondřej Páv, Miloš Buděšínský, Jakub Šebera, Vladimír Sychrovský
A benchmark for structural interpretation of the (31)P NMR shift and the (2)JP,C NMR spin-spin coupling in the phosphate group was obtained by means of theoretical calculations and NMR measurements in diethylphosphate (DEP) and 5,5-dimethyl-2-hydroxy-1,3,2-dioxaphosphinane 2-oxide (cDEP). The NMR parameters were calculated employing the B3LYP, BP86, BPW91, M06-2X, PBE0, KT2, KT3, MP2, and HF methods, and the 6-31+G(d), Iglo-n (n = II, III), cc-pVnZ (n = D, T, Q, 5), aug-cc-pVnZ (n = D, T and Q), and pcS-n and pcJ-n (n = 1, 2, 3, 4) bases, including the solvent effects described with explicit water molecules and/or the implicit Polarizable Continuum Model (PCM)...
November 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29167457/the-genetic-basis-for-the-adaptation-of-e-coli-to-sugar-synthesis-from-co2
#20
Elad Herz, Niv Antonovsky, Yinon Bar-On, Dan Davidi, Shmuel Gleizer, Noam Prywes, Lianet Noda-Garcia, Keren Lyn Frisch, Yehudit Zohar, David G Wernick, Alon Savidor, Uri Barenholz, Ron Milo
Understanding the evolution of a new metabolic capability in full mechanistic detail is challenging, as causative mutations may be masked by non-essential "hitchhiking" mutations accumulated during the evolutionary trajectory. We have previously used adaptive laboratory evolution of a rationally engineered ancestor to generate an Escherichia coli strain able to utilize CO2 fixation for sugar synthesis. Here, we reveal the genetic basis underlying this metabolic transition. Five mutations are sufficient to enable robust growth when a non-native Calvin-Benson-Bassham cycle provides all the sugar-derived metabolic building blocks...
November 22, 2017: Nature Communications
keyword
keyword
119221
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"