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Miloš Stanković, Milkica Nešić
While previous studies have shown that left- (vs. right-) hand contractions can improve the performance of global (vs. local) attention, these results were inconsistent in certain behavioral studies in which the left cerebral hemisphere was found to be specialized for local attention, while the right hemisphere was not specialized for global attention. Thus, we reexamined whether different global (vs. local) attention performances follow left- (vs. right-) hand contractions due to right (vs. left) hemisphere activation...
January 1, 2018: Perceptual and Motor Skills
Effrosyni Fatira, Miloš Havelka, Catherine Labbé, Alexandra Depincé, Viktoriia Iegorova, Martin Pšenička, Taiju Saito
Somatic cell nuclear transfer (SCNT) is a very promising cloning technique for reconstruction of endangered animals. The aim of the present research is to implement the interspecific SCNT (iSCNT) technique to sturgeon; one fish family bearing some of the most critically endangered species. We transplanted single cells enzymatically isolated from a dissociated fin-fragment of the Russian sturgeon (Acipenser gueldenstaedtii) into non-enucleated eggs of the sterlet (Acipenser ruthenus), two species bearing different ploidy (4n and 2n, respectively)...
April 16, 2018: Scientific Reports
Jana Plevkova, Jan Hanacek, Milos Tatar
No abstract text is available yet for this article.
April 13, 2018: Respiratory Physiology & Neurobiology
Federico Gaiti, William L Hatleberg, Miloš Tanurdžić, Bernard M Degnan
Although developmental regulation by long non-coding RNAs (lncRNAs) appears to be a widespread feature amongst animals, the origin and level of evolutionary conservation of this mode of regulation remain unclear. We have previously demonstrated that the sponge Amphimedon queenslandica -a morphologically-simple animal-developmentally expresses an array of lncRNAs in manner akin to more complex bilaterians (insects + vertebrates). Here, we first show that Amphimedon lncRNAs are expressed in specific cell types in larvae, juveniles and adults...
March 7, 2018: Non-Coding RNA
Dragana Vukov, Miloš Ilić, Mirjana Ćuk, Snežana Radulović, Ružica Igić, Georg A Janauer
We hypothesize that the physical features of river habitats and anthropogenic hydromorphological alterations influence macrophyte communities and lead to habitat fragmentation. Sampling included 1081 contiguous survey units positioned in the main channel and side arms along 588km of the Danube River, along its middle course. To identify habitat fragments, Multivariate Regression Tree analysis (MRT) was applied on macrophyte and environmental data. Indicator species analyses were combined with MRT. To identify habitat fragments on a scale larger than final MRT groups, we set thresholds for an MRT complexity parameter...
April 10, 2018: Science of the Total Environment
Wilmar M Wiersinga, Miloš Žarković, Luigi Bartalena, Simone Donati, Petros Perros, Onyebuchi Okosieme, Daniel Morris, Nicole Fichter, Juerg Lareida, Georg von Arx, Chantal Daumerie, Maria-Cristina Burlacu, George J Kahaly, Susanne Pitz, Biljana Beleslin, Jasmina Ćirić, Goksun Ayvaz, Onur Konuk, Fusun Balos Toruner, Mario Salvi, Danila Covelli, Nicola Currò, Laszlo Hegedüs, Thomas Heiberg Brix
Objective: To construct a predictive score for the development or progression of Graves' orbitopathy (GO) in Graves' hyperthyroidism (GH). Design: Prospective observational study in patients with newly diagnosed GH, treated with antithyroid drugs (ATD) for 18 months at ten participating centers from EUGOGO in 8 European countries. Methods: 348 patients were included with untreated GH but without obvious GO. Mixeded effects logistic regression was used to determine best predictors. A predictive score (called PREDIGO) was constructed...
April 12, 2018: European Journal of Endocrinology
L Pollak, R Huna-Baron, Michael Osherov, Milo Roni
The objective of this study is to examine the rate of horizontal canal BPPV recurrence of the same type and search for predisposing factors.
April 5, 2018: American Journal of Otolaryngology
Željko Debeljak, Sandra Dundović, Sonja Badovinac, Sanja Mandić, Miroslav Samaržija, Branko Dmitrović, Marija Miloš, Lana Maričić, Vatroslav Šerić, Vikica Buljanović
BACKGROUND: Carbohydrate sulfotransferases (CHST) were shown to be involved in carcinogenesis. The aim of the study was to assess the diagnostic value of serum CHST7 concentration in differentiation between lung cancer and non-malignant pulmonary inflammations. METHODS: Clinical case-control study involving 125 participants was conducted: the control group containing cases of pneumonia and chronic obstructive pulmonary disease was compared to the lung cancer group composed of primary and metastatic cancers...
April 12, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Siqi Liu, Adam Wright, Milos Hauskrecht
The objective of this work is to develop methods for detecting outliers in time series data. Such methods can become the key component of various monitoring and alerting systems, where an outlier may be equal to some adverse condition that needs human attention. However, real-world time series are often affected by various sources of variability present in the environment that may influence the quality of detection; they may (1) explain some of the changes in the signal that would otherwise lead to false positive detections, as well as, (2) reduce the sensitivity of the detection algorithm leading to increase in false negatives...
May 2017: Proceedings of the ... International Florida AI Research Society Conference
Alison G Abraham, Laura Girardat-Rotar, Sarah Ziegler, Markus Blum, Flavia Galletti, Milo A Puhan, Andreas L Serra
No abstract text is available yet for this article.
April 2018: Praxis
Heather Au, Noelia Rubio, Milo S P Shaffer
A non-destructive and versatile chemical reduction method was used to dissolve and subsequently brominate few-layer graphene sheets (FLGs); the direct covalent attachment of bromine to the graphene framework was demonstrated by X-ray photoelectron spectroscopy (XPS). The brominated few-layer graphenes (FLG-Br) provide a convenient, stable, liquid-phase precursor, suitable for the synthesis of a variety of directly functionalised graphenes. As an example, the FLG-Br species was used to initiate atom transfer radical polymerisation (ATRP), to obtain poly(methyl methacrylate) (PMMA)-grafted graphene (FLG-PMMA), which was six times more dispersible in acetone than controls...
January 7, 2018: Chemical Science
Idan Milo, Ronnie Blecher-Gonen, Zohar Barnett-Itzhaki, Raz Bar-Ziv, Orna Tal, Irina Gurevich, Tali Feferman, Ingo Drexler, Ido Amit, Philippe Bousso, Guy Shakhar
The bone marrow hosts NK cells whose distribution, motility and response to systemic immune challenge are poorly understood. At steady state, two-photon microscopy of the bone marrow in Ncr1gfp/+ mice captured motile NK cells interacting with dendritic cells. NK cells expressed markers and effector molecules of mature cells. Following poly (I:C) injection, RNA-Seq of NK cells revealed three phases of transcription featuring immune response genes followed by posttranscriptional processes and proliferation. Functionally, poly (I:C) promoted upregulation of granzyme B, enhanced cytotoxicity in vitro and in vivo, and, in the same individual cells, triggered proliferation...
April 6, 2018: European Journal of Immunology
Katarína Vorčáková, Magdaléna Májeková, Eva Horáková, Pavel Drabina, Miloš Sedlák, Šárka Štěpánková
Based on current treatment of Alzheimer's disease, where the carbamate inhibitor Rivastigmine is used, two series of carbamate derivatives were prepared: (i) N-phenylcarbamates with additional carbamate group (1-12) and (ii) N-phenylcarbamates with monosaccharide moiety (13-24). All compounds were tested for the inhibitory effect on both of the cholinesterases, electric eel acetylcholinesterase (eeAChE) and butyrylcholinesterase from equine serum (eqBChE) and the inhibitory activity (expressed as IC50 values) was compared with that of the established drugs Galanthamine and Rivastigmine...
March 28, 2018: Bioorganic Chemistry
Federico Gaiti, Bernard M Degnan, Miloš Tanurdžić
How animals evolved from a single-celled ancestor over 700 million years ago is poorly understood. Recent transcriptomic and chromatin analyses in the sponge Amphimedon queenslandica, a morphologically-simple representative of one of the oldest animal phyletic lineages, have shed light on what innovations in the genome and its regulation underlie the emergence of animal multicellularity. Comparisons of the regulatory genome of this sponge with those of more complex bilaterian model species and even simpler unicellular relatives have revealed that fundamental changes in genome regulatory complexity accompanied the evolution of animal multicellularity...
April 4, 2018: RNA Biology
Nathalie J Vielle, Beatrice Zumkehr, Obdulio García-Nicolás, Fabian Blank, Miloš Stojanov, Didier Musso, David Baud, Artur Summerfield, Marco P Alves
While Zika virus (ZIKV) circulated for decades (African lineage strains) without report of outbreaks and severe complications, its emergence in French Polynesia and subsequently in the Americas (Asian lineage strains) was associated with description of severe neurological defects in newborns/neonates and adults. With the aim to identify virus lineage-dependent factors, we compared cell susceptibility, virus replication, cell death and innate immune responses following infection with two African and three contemporary Asian lineage strains of ZIKV...
April 3, 2018: Scientific Reports
Thomas A Schwann, Paul S Ramia, Joseph R Habib, Milo C Engoren, Mark R Bonnell, Robert H Habib
BACKGROUND: The multiarterial grafting survival advantage noted in the overall population undergoing coronary artery bypass grafting is not well defined in the obese. We investigated the early to late survival effects of the radial artery in left internal thoracic artery-based multiarterial bypass grafting (radial artery-multiarterial bypass grafting) versus single arterial bypass grafting (left internal thoracic artery-single arterial bypass grafting) in obese patients. METHODS: We analyzed 15-year Kaplan-Meier survival in 6102 patients receiving primary, left internal thoracic artery-based coronary artery bypass grafting with 2 or more grafts divided into body mass index groups: nonobese (<30 kg/m2 ) and all-obese, comprised of mildly obese (30-35 kg/m2 ) and morbidly obese (>35 kg/m2 )...
March 11, 2018: Journal of Thoracic and Cardiovascular Surgery
Juraj Majtan, Milos Jesenak
β-glucans are derived from a variety of sources including yeast, grain and fungus and belong to the class of drugs known as biological response modifiers. They possess a broad spectrum of biological activities that enhance immunity in humans. One promising area for β-glucans' application is dermatology, including wound care. Topical applications of β-glucans are increasing, especially due to their pluripotent properties. Macrophages, keratinocytes and fibroblasts are considered the main target cells of β-glucans during wound healing...
April 1, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Veronika Moslerová, Martina Dadáková, Ján Dupej, Eva Hoffmannova, Jiří Borský, Miloš Černý, Přemysl Bejda, Karolína Kočandrlová, Jana Velemínská
OBJECTIVES: To evaluate facial asymmetry changes in pre-school patients with orofacial clefts after neonatal cheiloplasty and to compare facial asymmetry with age-matched healthy controls. METHODS AND MATERIALS: The sample consisted of patients with unilateral cleft lip (UCL), unilateral cleft lip and palate (UCLP), and bilateral cleft lip and palate (BCLP). The patients were divided in two age groups with a mean age of 3 years (n = 51) and 4.5 years (n = 45), respectively, and 78 age-matched individuals as controls...
May 2018: International Journal of Pediatric Otorhinolaryngology
Kristyna Vrbova, Jan Prasko, Michaela Holubova, Milos Slepecky, Marie Ociskova
OBJECTIVE: The purpose of the investigation was to explore the relationship between positive or negative symptoms, social anxiety, hope, personality, and self-stigma in patients with schizophrenia spectrum disorders. METHOD: 57 outpatients took part in this cross-sectional study. The structured interview M.I.N.I. International Neuropsychiatric Interview was used to confirm the diagnosis. All patients completed the Liebowitz Social Anxiety Scale, Internalized Stigma of Mental Illness Scale, Beck Depression Inventory-II, Beck Anxiety Inventory, Adult Dispositional Hope Scale, and Temperament and Character Inventory - Revised...
March 1, 2018: Neuro Endocrinology Letters
Katerina Honkova, Andrea Rossnerova, Jitka Pavlikova, Vlasta Svecova, Jiri Klema, Jan Topinka, Alena Milcova, Helena Libalova, Hyunok Choi, Milos Veleminsky, Radim J Sram, Pavel Rossner
Prenatal exposure to air pollution is associated with intrauterine growth restriction and low birth weight. Gene expression changes in newborns in relation to air pollution have not been sufficiently studied. We analyzed whole genome expression in cord blood leukocytes of 202 newborns from diverse localities of the Czech Republic, differing among other factors in levels of air pollution: the district of Karvina (characterized by higher concentration of air pollutants) and Ceske Budejovice (lower air pollution levels)...
March 30, 2018: Environmental and Molecular Mutagenesis
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