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G Pedretti, V Milo, S Ambrogio, R Carboni, S Bianchi, A Calderoni, N Ramaswamy, A S Spinelli, D Ielmini
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June 18, 2018: Scientific Reports
Kristyna Vrbova, Jan Prasko, Marie Ociskova, Michaela Holubova, Krystof Kantor, Antonin Kolek, Aleš Grambal, Milos Slepecky
Background and aim: Patients who have schizophrenia are more prone to suicidal behavior than the general population. This study aimed to find connections between suicidality and self-stigma, hope, and personality traits in patients with schizophrenia. Methods: Forty-eight stabilized outpatients with schizophrenia attended this cross-sectional study. Patients were diagnosed by the Mini International Neuropsychiatric Interview (MINI) using the ICD-10 research diagnostic criteria...
2018: Neuropsychiatric Disease and Treatment
Petr Stastny, James J Tufano, Jan Kregl, Miroslav Petr, Dusan Blazek, Michal Steffl, Robert Roczniok, Milos Fiala, Artur Golas, Piotr Zmijewski
Background: Visual feedback may help elicit peak performance during different types of strength and power testing, but its effect during the anaerobic Wingate test is unexplored. Therefore, the purpose of this study was to determine the effect of visual feedback on power output during a hockey-specific intermittent Wingate test (AnWT6x6) consisting of 6 stages of 6 s intervals with a 1:1 work-to-rest ratio. Methods: Thirty elite college-aged hockey players performed the AnWT6x6 with either constant ( n = 15) visual feedback during all 6 stages (CVF) or restricted ( n = 15) visual feedback (RVF) where feedback was shown only during the 2nd through 5th stages...
April 9, 2018: Sports
Marco Siano, Vittoria Espeli, Nicolas Mach, Paolo Bossi, Lisa Licitra, Michele Ghielmini, Milo Frattini, Silvana Canevari, Loris De Cecco
OBJECTIVE: Platinum-based chemotherapy plus the anti-EGFR monoclonal antibody (mAb) cetuximab is used to treat recurrent/metastatic (RM) head-neck squamous cell carcinoma (HNSCC). Recently, we defined Cluster3 gene-expression signature as a potential predictor of favorable progression-free survival (PFS) in cetuximab-treated RM-HNSCC patients and predictor of partial metabolic FDG-PET response in an afatinib window-of-opportunity trial. Another anti-EGFR-mAb (panitumumab) was used as the treatment agent in RM-HNSCC patients in the phase II PANI01trial...
July 2018: Oral Oncology
Miloš Vittori, Vesna Srot, Birgit Bussmann, Felicitas Predel, Peter A van Aken, Jasna Štrus
Terrestrial isopods possess large sensory setae on their walking legs. Increased fracture resistance of these elongated structures is of crucial importance, making the exoskeleton forming the setae an interesting durable material that may inspire biomimetic designs. We studied the cuticle of the sensory setae with analytical electron microscopy in order to gain detailed insights into its structure and composition at the nanometer scale and identify features that increase the fracture resistance of these minute skeletal elements...
June 9, 2018: Micron: the International Research and Review Journal for Microscopy
Vinita Mittal, Milos Nedeljkovic, David J Rowe, Ganapathy Senthil Murugan, James S Wilkinson
We demonstrate the integration of paper fluidics with mid-infrared (MIR) chalcogenide waveguides to introduce liquid samples to the waveguide evanescent field for analysis. Spectroscopy of model analytes (water and isopropyl alcohol) having well-defined mid-IR absorptions, on a ZnSe rib waveguide fabricated on silicon, is demonstrated in the wavelength range of 2.6-3.7 µm, showing their O-H and C-H stretching absorptions. The results are compared with a theoretical waveguide model, achieving good agreement...
June 15, 2018: Optics Letters
Nenad Vukmirović, Miloš Janjić, Petar M Djurić, Miljko Erić
In this paper, we propose a massive MIMO (multiple-input-multiple-output) architecture with distributed steerable phased antenna subarrays for position estimation in the mmWave range. We also propose localization algorithms and a multistage/multiresolution search strategy that resolve the problem of high side lobes, which is inherent in spatially coherent localization. The proposed system is intended for use in line-of-sight indoor environments. Time synchronization between the transmitter and the receiving system is not required, and the algorithms can also be applied to a multiuser scenario...
2018: EURASIP Journal on Advances in Signal Processing
Aaron Zhenghui Thong, Milo S P Shaffer, Andrew P Horsfield
A donor-acceptor system, 4-thiophenyl-azafulleroid (4TPA-C60 ), is investigated at the point of HOMO/LUMO resonance and beyond to understand how negative differential resistance (NDR) features may be observed in such systems. Our previous investigation showed that charge transfer between the occupied and unoccupied states at resonance hindered crossing of the HOMO and LUMO levels, thus preventing the formation of an NDR feature. In this work, it is shown that the negative differential resistance feature of 4TPA-C60 can be tailored based on the couplings at the metal/molecule interface...
June 14, 2018: Scientific Reports
Jacques Bobet, Kei Masani, Milos R Popovic, Albert H Vette
Recent work suggests that functional electrical stimulation can be used to enhance dynamic trunk stability following spinal cord injury. In this context, knowledge of the relation between trunk kinematics and muscle activation in non-disabled individuals may assist in developing kinematics-based neuroprostheses. Our objective was therefore to predict the activation profiles of the major trunk muscles from trunk kinematics following multi-directional perturbations during sitting. Trunk motion and electromyograms (EMG) from ten major trunk muscles were acquired in twelve non-disabled, seated individuals who experienced a force of approximately 200 N applied to the trunk in eight horizontal directions...
June 9, 2018: Medical Engineering & Physics
Kevin C Conlon, Milos D Miljkovic, Thomas A Waldmann
Cytokines are major regulators of innate and adaptive immunity that enable cells of the immune system to communicate over short distances. Cytokine therapy to activate the immune system of cancer patients has been an important treatment modality and continues to be a key contributor to current clinical cancer research. Interferon alpha (IFNα) is approved for adjuvant treatment of completely resected high-risk melanoma patients and several refractory malignancies. High-dose interleukin-2 (HDIL-2) is approved for treatment of metastatic renal cell cancer and melanoma, but both agents are currently less commonly used with the development of newer agents...
June 11, 2018: Journal of Interferon & Cytokine Research
A Dieter Schlüter, Vivian Müller, Antoine Hinaut, Mina Moradi, Milos Baljozovic, Thomas Jung, Patrick Shahgaldian, Helmuth Möhwald, Gregor Hofer, Martin Kröger, Benjamin King, Ernst Meyer, Thilo Glatzel
A trifunctional, partially fluorinated anthracene-substituted triptycene monomer is spread at the air/water interface into a monolayer, which is transformed into a long-range ordered 2D polymer by irradiation with a standard ultraviolet lamp using 365 nm light. The polymer is analyzed by Brewster angle microscopy directly at this interface and by scanning tunneling microscopy measurements and non-contact atomic force microscopy (nc-AFM), both after transfer from below the interface onto highly oriented pyrolytic graphite and then into ultra-high vacuum...
June 11, 2018: Angewandte Chemie
Mohamed Habib, Milos Trajkovic, Marco W Fraaije
Syringaresinol was synthesized in a one-pot conversion containing eugenol oxidase (EUGO) and horseradish peroxidase (HRP) using the relatively cheap 2,6-dimethoxy-4-allylphenol as a substrate. This conversion is fully coupled as the hydrogen peroxide generated from the reaction of EUGO with the substrate is utilized by the HRP to convert the formed sinapyl alcohol into syringaresinol. To improve the performance of EUGO on 2,6-dimethoxy-4-allylphenol, structure-inspired enzyme engineering was performed. This yielded the I427A EUGO mutant that is significantly more efficient with 2,6-dimethoxy-4-allylphenol...
June 1, 2018: ACS Catalysis
Sharon Gabison, Sunita Mathur, Mary C Verrier, Ethne Nussbaum, Milos R Popovic, Dany H Gagnon
BACKGROUND: Characterization of ischial tissue health using a standardized diagnostic ultrasound protocol capturing thickness and gray scale analysis has not been established. OBJECTIVES: This study evaluates inter-participant and inter-trial reliability of thickness and gray scale analysis of ultrasound images of tissues overlying the ischial tuberosity. It provides recommendations for the number of images required to minimize the standard error of measurement (SEM) and determines the number of images required for thickness, gray scale and contrast values that exceed an a-priori minimal detectable change (MDC) for repeated tissue assessment...
May 4, 2018: Journal of Tissue Viability
Hanh Ngoc My Duong, Minh Anh Phan Nguyen, Mehran Kianinia, Takeshi Ohshima, Hiroshi Abe, Kenji Watanabe, Takashi Taniguchi, James H Edgar, Igor Aharonovich, Milos Toth
Hexagonal Boron Nitride (hBN) mono and multilayers are promising hosts for room temperature single photon emitters (SPEs). In this work we explore high energy (~ MeV) electron irradiation as a means to generate stable SPEs in hBN. We investigate four types of exfoliated hBN flakes - namely, high purity multilayers, isotopically pure hBN, carbon rich hBN multilayers and monolayered material - and find that electron irradiation increases emitter concentrations dramatically in all samples. Furthermore, the engineered emitters are located throughout hBN flakes (not only at flake edges or grain boundaries), and do not require activation by high temperature annealing of the host material after electron exposure...
June 8, 2018: ACS Applied Materials & Interfaces
H Bruhn, M Strandéus, P Milos, M Hallbeck, M Vrethem, Jonas Lind
OBJECTIVES: The median survival in glioblastoma (GBM) patients used to be less than 1 year. Surgical removal of the tumor with subsequent concomitant radiation/temozolomide (the Stupp regimen) has been shown to prolong survival. The Stupp protocol was implemented in the county of Jönköping in 2006. The purpose of this study was to examine if the Stupp treatment has prolonged overall survival, in an unselected patient cohort with histologically verified GBM. MATERIAL AND METHOD: This study includes all patients from the county of Jönköping, with a diagnosis of GBM from January 2001 to December 2012...
June 8, 2018: Acta Neurologica Scandinavica
Miho Iwasaki, Yasuki Noguchi, Ryusuke Kakigi
Some researchers in aesthetics assume visual features related to aesthetic perception (e.g. golden ratio and symmetry) commonly embedded in masterpieces. If this is true, an intriguing hypothesis is that the human brain has neural circuitry specialized for the processing of visual beauty. We presently tested this hypothesis by combining a neuroimaging technique with the repetition suppression (RS) paradigm. Subjects (non-experts in art) viewed two images of sculptures sequentially presented. Some sculptures obeyed the golden ratio (canonical images), while the golden proportion were impaired in other sculptures (deformed images)...
June 7, 2018: Brain Topography
Luka Milosevic, Suneil K Kalia, Mojgan Hodaie, Andres M Lozano, Milos R Popovic, William D Hutchison
Ventral intermediate thalamic deep brain stimulation is a standard therapy for the treatment of medically refractory essential tremor and tremor-dominant Parkinson's disease. Despite the therapeutic benefits, the mechanisms of action are varied and complex, and the pathophysiology and genesis of tremor remain unsubstantiated. This intraoperative study investigated the effects of high frequency microstimulation on both neuronal firing and tremor suppression simultaneously. In each of nine essential tremor and two Parkinson's disease patients who underwent stereotactic neurosurgery, two closely spaced (600 µm) microelectrodes were advanced into the ventral intermediate nucleus...
June 5, 2018: Brain: a Journal of Neurology
David Aguinaga, Mireia Medrano, Arnau Cordomí, Mireia Jiménez-Rosés, Edgar Angelats, Mireia Casanovas, Ignacio Vega-Quiroga, Enric I Canela, Milos Petrovic, Katia Gysling, Leonardo Pardo, Rafael Franco, Gemma Navarro
Despite ancient knowledge on cocaine appetite-suppressant action, the molecular basis of such fact remains unknown. Addiction/eating disorders (e.g., binge eating, anorexia, bulimia) share a central control involving reward circuits. However, we here show that the sigma-1 receptor (σ1 R) mediates cocaine anorectic effects by interacting in neurons with growth/hormone/secretagogue (ghrelin) receptors. Cocaine increases colocalization of σ1 R and GHS-R1a at the cell surface. Moreover, in transfected HEK-293T and neuroblastoma SH-SY5Y cells, and in primary neuronal cultures, pretreatment with cocaine or a σ1 R agonist inhibited ghrelin-mediated signaling, in a similar manner as the GHS-R1a antagonist YIL-781...
June 7, 2018: Molecular Neurobiology
Thomas A Schwann, Paul S Ramia, Milo C Engoren, Mark R Bonnell, Matthew Goodwin, Ian Monroe, Robert H Habib
OBJECTIVES: We evaluated the presence of an 'obesity paradox' in coronary artery bypass grafting (CABG) patients, determined its time course and ascertained whether it is associated with improved cardiovascular (CV) survival versus non-CV survival. METHODS: A retrospective analysis of 3 prospectively collected databases was conducted. A fifteen-year Kaplan-Meier analysis in 7091 CABG patients was performed and repeated in 5 body mass index [BMI (kg/m2)] cohorts [Normal (18...
June 2, 2018: European Journal of Cardio-thoracic Surgery
Yuan-Ta Lin, Jinsoo Seo, Fan Gao, Heather M Feldman, Hsin-Lan Wen, Jay Penney, Hugh P Cam, Elizabeta Gjoneska, Waseem K Raja, Jemmie Cheng, Richard Rueda, Oleg Kritskiy, Fatema Abdurrob, Zhuyu Peng, Blerta Milo, Chung Jong Yu, Sara Elmsaouri, Dilip Dey, Tak Ko, Bruce A Yankner, Li-Huei Tsai
The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for sporadic Alzheimer's disease (sAD). However, the cell-type-specific functions of APOE4 in relation to AD pathology remain understudied. Here, we utilize CRISPR/Cas9 and induced pluripotent stem cells (iPSCs) to examine APOE4 effects on human brain cell types. Transcriptional profiling identified hundreds of differentially expressed genes in each cell type, with the most affected involving synaptic function (neurons), lipid metabolism (astrocytes), and immune response (microglia-like cells)...
May 22, 2018: Neuron
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