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Kerstin U Ludwig, Anne C Böhmer, John Bowes, Miloš Nikolić, Nina Ishorst, Niki Wyatt, Nigel L Hammond, Lina Gölz, Frederic Thieme, Sandra Barth, Hannah Schuenke, Johanna Klamt, Malte Spielmann, Khalid Aldhorae, Augusto Rojas-Martinez, Markus M Nöthen, Alvaro Rada-Iglesias, Michael J Dixon, Michael Knapp, Elisabeth Mangold
Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is among the most common human birth defects with multifactorial etiology. Here, we present results from a genome-wide imputation study of nsCL/P in which, after adding replication cohort data, four novel risk loci for nsCL/P are identified (at chromosomal regions 2p21, 14q22, 15q24 and 19p13). On a systematic level, we show that the association signals within this high-density dataset are enriched in functionally-relevant genomic regions that are active in both human neural crest cells (hNCC) and mouse embryonic craniofacial tissue...
January 13, 2017: Human Molecular Genetics
Michael R Mathis, Subramanian Sathishkumar, Sachin Kheterpal, Matthew D Caldwell, Francis D Pagani, Elizabeth S Jewell, Milo C Engoren
BACKGROUND: Patients with left ventricular assist devices presenting for noncardiac surgery are increasingly commonplace; however, little is known about their outcomes. Accordingly, the authors sought to determine the frequency of complications, risk factors, and staffing patterns. METHODS: The authors performed a retrospective study at their academic tertiary care center, investigating all adult left ventricular assist device patients undergoing noncardiac surgery from 2006 to 2015...
January 6, 2017: Anesthesiology
Sena Bluemel, Dieter Menne, Gabriella Milos, Oliver Goetze, Michael Fried, Werner Schwizer, Mark Fox, Andreas Steingoetter
BACKGROUND: Whether gastrointestinal motor and sensory function is primary cause or secondary effect of abnormal body weight is uncertain. Moreover, studies relating continuous postprandial sensations of satiation to measurable pathology are scarce. This work assessed postprandial gastrointestinal function and concurrent sensations of satiation across a wide range of body weight and after weight change. METHODS: Patients with anorexia nervosa (AN) and obesity (OB) were investigated in reference to normal weight controls (HC)...
January 5, 2017: BMC Gastroenterology
Lazar B Davidovic, Igor B Koncar, Dusan M Kostic, Milos M Sladojevic, Dragan M Markovic
No abstract text is available yet for this article.
February 2017: Journal of Cardiovascular Surgery
Milos Radovic, Mohamed Ghalwash, Nenad Filipovic, Zoran Obradovic
BACKGROUND: Feature selection, aiming to identify a subset of features among a possibly large set of features that are relevant for predicting a response, is an important preprocessing step in machine learning. In gene expression studies this is not a trivial task for several reasons, including potential temporal character of data. However, most feature selection approaches developed for microarray data cannot handle multivariate temporal data without previous data flattening, which results in loss of temporal information...
January 3, 2017: BMC Bioinformatics
Giovanni M Baez, Eduardo Trevisol, Rafael V Barletta, Beatriz O Cardoso, Alessandro Ricci, Jerry N Guenther, Nicole E Cummings, Milo C Wiltbank
In bovine pregnancy, regression or maintenance of the corpus luteum (CL) is mediated through local communication pathways between embryo, uterus, and ovary with Days 16 to 25 of pregnancy generally recognized as the pivotal period determining either luteolysis or prevention of luteolysis. To evaluate this concept, accessory CL was generated by treating Holstein lactating dairy cows (n = 718) with GnRH on Day 5 of the first follicular wave to produce an accessory CL on the ovary either contralateral or ipsilateral to the gravid horn...
February 2017: Theriogenology
Noemi Bertel, Fabienne Witassek, Milo Puhan, Paul Erne, Hans Rickli, Barbara Naegeli, Giovanni Pedrazzini, Jean-Christophe Stauffer, Dragana Radovanovic
BACKGROUND: Diagnosis of acute myocardial infarction (MI) is challenging in pacemaker patients. Little is known about this patient group. METHODS: Patients with MI enrolled in the Swiss national AMIS Plus registry between January 2005 and December 2015 were analyzed. All patients with either paced ventricular rhythm or sinus rhythm with intrinsic ventricular conduction (IVC) were included in this study. Outcomes using crude data and propensity score matching were compared between patients with pacemaker rhythm and patients with IVC...
December 20, 2016: International Journal of Cardiology
Nataša Mitrović, Marina Zarić, Dunja Drakulić, Jelena Martinović, Jean Sévigny, Miloš Stanojlović, Nadežda Nedeljković, Ivana Grković
No abstract text is available yet for this article.
December 29, 2016: Journal of Molecular Neuroscience: MN
Gunnar Wichmann, Anne Krüger, Andreas Boehm, Marlen Kolb, Mathias Hofer, Milos Fischer, Stefan Müller, Sandra Purz, Patrick Stumpp, Osama Sabri, Andreas Dietz, Regine Kluge
BACKGROUND: Long-term laryngectomy-free (LFS), tumour-specific (TSS) and overall survival (OS) is achieved by non-surgical larynx preservation (LP) only in a proportion of patients with locally advanced laryngeal or hypopharyngeal cancer. A score facilitating decision-making after 1 cycle induction chemotherapy (IC-1) may improve LFS and TSS. METHODS: Early response to IC-1 with TPF ± cetuximab was assessed in 52 patients using endoscopic tumour staging for selecting total laryngectomy for non-responders with endoscopic tumour surface shrinkage <30% versus induction chemotherapy plus radiotherapy (IC + RT) for responders...
December 26, 2016: European Journal of Cancer
Tao Ye, Miloš Petrović, Shengjie Peng, Jeremy Lee Kong Yoong, Chellappan Vijila, Seeram Ramakrishna
PbI2-enriched mixed perovskite film [FA0.81MA0.15Pb(I0.836Br0.15)3] has been widely studied due to its great potential in perovskite solar cell (PSC) applications. Herein, a FA0.81MA0.15Pb(I0.836Br0.15)3 film has been fabricated with the temperature-dependent optical absorption spectra utilized to determine its exciton binding energy. A ∼13 meV exciton binding energy is estimated, and a near-unity fraction of free carriers out of the total photoexcitons has been obtained in the solar cell operating regime at equilibrium state...
January 13, 2017: ACS Applied Materials & Interfaces
Milica G Paunović, Branka I Ognjanović, Miloš M Matić, Andraš Š Štajn, Zorica S Saičić
Nicotine is a potential inducer of oxidative stress, through which it can damage numerous biological molecules. The aim of our study was to investigate the prooxidative effects of nicotine and protective (additive or synergistic) effects of quercetin and vitamin C in the blood of experimental animals, to determine whether the combination of these antioxidants might be beneficial for clinical purposes. Wistar albino rats were receiving intraperitoneal nicotine injection (0.75 mg kg-1 per day) or saline (control group) or nicotine plus quercetin (40 mg kg-1 per day) and vitamin C (100 mg kg-1 per day) for three consecutive days...
December 1, 2016: Arhiv za Higijenu Rada i Toksikologiju
Danijela M Cvetković, Marko N Živanović, Milena G Milutinović, Tijana R Djukić, Miloš D Radović, Aleksandar M Cvetković, Nenad D Filipović, Nebojša D Zdravković
PURPOSE: To study the effects of electroporation on different cell lines. MATERIAL: The effects of electroporation on human breast cancer (MDA-MB-231), human colon cancer (SW-480 and HCT-116), human fibroblast cell line (MRC-5), primary human aortic smooth muscle cells (hAoSMC) and human umbilical vein endothelial cells (HUVEC) were studied. Real-time technology was used for cell viability monitoring. Acridine orange/ethidium bromide assay was applied for cell death type determination...
October 22, 2016: Bioelectrochemistry
Katerina Urbancova, Darina Lankova, Pavel Rossner, Andrea Rossnerova, Vlasta Svecova, Monika Tomaniova, Milos Veleminsky, Radim J Sram, Jana Hajslova, Jana Pulkrabova
Polycyclic aromatic hydrocarbons (PAHs) represent a large group of ubiquitous contaminants of the environment, including food chain where they are released as by-products of incomplete combustion of an organic matter. Epidemiological studies have shown that exposure to PAHs correlated with increased incidence of cancer. Carcinogenicity is associated mainly with metabolites that are formed during metabolic degradation of these substances in exposed organism. In this study monohydroxylated PAHs (OH-PAHs), the major metabolites excreted into urine, were determined in 531 urine samples collected from mothers and their newborns from two localities of the Czech Republic - heavily air polluted Karvina and control locality of Ceske Budejovice and in two sampling rounds - August-October 2013 (summer, less air polluted season) and January-April 2014 (winter, more air polluted season)...
October 29, 2016: Science of the Total Environment
Iva Brynychova, Iva Hoffmanova, Milos Dvorak, Pavlina Dankova
BACKGROUND: Celiac disease (CD) is an organ-specific autoimmune disease, and both adaptive and innate immunity are involved in its development. OBJECTIVES: The aim of the study was to determine whether the markers of intestinal mucosal inflammation in CD can be detected in peripheral blood monocytes (PBMs), and whether the immune properties of PBMs change as the clinical signs and symptoms of CD improve after the introduction of a gluten-free diet (GFD). The focus was on changes in mRNA expression of selected toll-like receptors (TLR2, TLR4, TLR7), stress cytokine prolactin (PRL), and proand anti-inflammatory cytokines (TNF-α, IL-6, IL-12, IL-10) in PBMs...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Miloš Nikolić, Argyris Papantonis, Alvaro Rada-Iglesias
Genome-wide association studies (GWAS) have emerged as a powerful tool to uncover the genetic basis of human common diseases, which often show a complex, polygenic and multi-factorial etiology. These studies have revealed that 70-90% of all single nucleotide polymorphisms (SNPs) associated with common complex diseases do not occur within genes (i.e., they are non-coding), making the discovery of disease-causative genetic variants and the elucidation of the underlying pathological mechanisms far from straightforward...
December 22, 2016: Human Molecular Genetics
Seshadri C Mudumbai, Tessa L Walters, Steven K Howard, T Edward Kim, Gregory Milo Lochbaum, Stavros G Memtsoudis, Zeev N Kain, Alex Kou, Robert King, Edward R Mariano
BACKGROUND: The challenge of knowledge translation in medical settings is well known, and implementing change in clinical practice can take years. For the increasing number total knee arthroplasty (TKA) patients annually, there is ample evidence to endorse neuraxial anesthesia over general anesthesia. The rate of adoption of this practice, however, is slow at the current time. We hypothesized that a Perioperative Surgical Home (PSH) model facilitates rapid change implementation in anesthesia...
December 2016: Healthcare
Marta Marquié, Marc D Normandin, Avery C Meltzer, Michael Siao Tick Chong, Nicolas V Andrea, Alejandro Antón-Fernández, William E Klunk, Chester A Mathis, Milos D Ikonomovic, Manik Debnath, Elizabeth A Bien, Charles R Vanderburg, Isabel Costantino, Sara Makaretz, Sarah L DeVos, Derek H Oakley, Stephen N Gomperts, John H Growdon, Kimiko Domoto-Reilly, Diane Lucente, Bradford C Dickerson, Matthew P Frosch, Bradley T Hyman, Keith A Johnson, Teresa Gómez-Isla
OBJECTIVE: Recent studies have shown that PET tracer AV-1451 exhibits high binding affinity for paired helical filament (PHF)-tau pathology in Alzheimer's brains. However, the ability of this ligand to bind to tau lesions in other tauopathies remains controversial. Our goal was to examine the correlation of in vivo and postmortem AV-1451 binding patterns in three autopsy-confirmed non-Alzheimer tauopathy cases. METHODS: We quantified in vivo retention of [F-18]-AV-1451 and performed autoradiography, [H-3]-AV-1451 binding assays and quantitative tau measurements in postmortem brain samples from two Progressive Supranuclear Palsy (PSP) cases and a MAPT P301L mutation carrier...
December 20, 2016: Annals of Neurology
Pavel Švec, Stanislava Králová, Hans-Jürgen Busse, Tanita Kleinhagauer, Roman Pantůček, Ivana Mašlaňová, Margo Cnockaert, Peter Vandamme, Eva Staňková, Tereza Gelbíčová, Pavla Holochová, Miloš Barták, Kamila Kýrová, Ivo Sedláček
A taxonomic study performed on 17 Gram-stain-negative rod-shaped bacterial strains originating from Antarctic environment is described. Initial phylogenetic analysis using 16S rRNA gene sequencing differentiated the strains into four groups belonging into the genus Pedobacter but they were separated from all hitherto described Pedobacter spp. Group I (n=8) was closest to Pedobacter aquatilis (97.8 % 16S rRNA gene sequence similarity). Group II (n=2) and group III (n=4) were closely related (98.8 % 16S rRNA gene sequence similarity) and showed Pedobacter jejuensis as their common nearest neighbour...
December 20, 2016: International Journal of Systematic and Evolutionary Microbiology
Ondřej Páv, Ivan Barvík, Radek Liboska, Magdalena Petrová, Ondřej Šimák, Šárka Rosenbergová, Pavel Novák, Miloš Buděšínský, Ivan Rosenberg
The concept of conformational restriction leading to the preorganization of modified strands has proven to be successful and has afforded nucleic acid analogues with many interesting properties suitable for various biochemical applications. We utilized this concept to prepare a set of constrained oligonucleotides derived from 1,4-dioxane and 1,3-dioxolane-locked nucleoside phosphonates and evaluated their hybridization affinities towards their complementary RNA strands. With an increase of ΔTm per modification up to +5...
December 20, 2016: Organic & Biomolecular Chemistry
Zsofia I Kovacs, Saejeong Kim, Neekita Jikaria, Farhan Qureshi, Blerta Milo, Bobbi K Lewis, Michele Bresler, Scott R Burks, Joseph A Frank
MRI-guided pulsed focused ultrasound (pFUS) combined with systemic infusion of ultrasound contrast agent microbubbles (MB) causes localized blood-brain barrier (BBB) disruption that is currently being advocated for increasing drug or gene delivery in neurological diseases. The mechanical acoustic cavitation effects of opening the BBB by low-intensity pFUS+MB, as evidenced by contrast-enhanced MRI, resulted in an immediate damage-associated molecular pattern (DAMP) response including elevations in heat-shock protein 70, IL-1, IL-18, and TNFα indicative of a sterile inflammatory response (SIR) in the parenchyma...
January 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
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