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https://www.readbyqxmd.com/read/29684310/assessing-the-quality-of-life-in-patients-with-dentofacial-deformities-before-and-after-orthognathic-surgery
#1
Hong Sun, Hong-Tao Shang, Li-Sheng He, Ming-Chao Ding, Zhong-Ping Su, Yu-Lin Shi
PURPOSE: This study aimed to assess the effect of health-related quality of life (QoL) among patients with dentofacial deformities who underwent orthognathic surgery compared with a control group without dentofacial deformities by use of generic oral health and condition-specific approaches. PATIENTS AND METHODS: In this prospective study, 2 questionnaires were administered to 85 patients (31 male and 54 female patients) who were evaluated before undergoing orthognathic surgery...
March 31, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29683562/absolute-bioavailability-of-osimertinib-in-healthy-adults
#2
Karthick Vishwanathan, Karen So, Karen Thomas, Alex Bramley, Stephen English, Jo Collier
Osimertinib is a third-generation, central nervous system-active, epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) selective for EGFR-TKI sensitizing and T790M resistance mutations. This phase 1, open-label study (NCT02491944) investigated absolute bioavailability and pharmacokinetics (PK) of oral and intravenous (IV) osimertinib. Ten healthy subjects (21-61 years) received a single oral 80-mg dose concomitantly with a 100 μg (containing 1 μCi) IV microtracer dose of [14 C]osimertinib...
April 23, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29682292/plasma-procalcitonin-concentrations-are-increased-in-dogs-with-sepsis
#3
Robert Goggs, Matthew Milloway, Roberta Troia, Massimo Giunti
Sepsis, the life-threatening organ dysfunction caused by a dysregulated host response to infection, is difficult to identify and to prognosticate for. In people with sepsis, procalcitonin (PCT) measurement aids diagnosis, enables therapeutic monitoring and improves prognostic accuracy. This study used a commercial canine PCT assay to measure plasma PCT concentrations in dogs with gastric dilatation volvulus (GDV) syndrome and in dogs with sepsis. It was hypothesised that dogs with GDV syndrome and with sepsis have greater plasma PCT concentrations than healthy dogs and that dogs with sepsis have greater PCT concentrations than dogs with GDV syndrome...
2018: Veterinary Record Open
https://www.readbyqxmd.com/read/29682124/primary-external-iliac-venous-aneurysm-a-case-report
#4
Minami Taki, Takashi Miura, Takahiro Kobayashi, Toshio Kasai, Takahisa Maruyama, Minako Hayakawa, Yu Matsumura, Fumitaka Yamaki, Uichi Ikeda
Primary iliac venous aneurysm is an exceedingly rare abnormality that can be complicated by pulmonary embolism, thrombosis, and rupture. Here we report the case of an otherwise healthy 40-year-old man with a unilateral external iliac vein aneurysm without any evidence of an arteriovenous fistula, proximal stenosis, or obstruction, as reported on computed tomography. Pulmonary embolism was diagnosed using 99m Tc-macroaggregated albumin scintigraphy. To prevent life-threatening complications, we treated the patient with anticoagulant therapy and performed aneurysmectomy with reconstruction using a saphenous vein graft patch...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29681953/omega-3-fatty-acid-supplementation-improves-heart-rate-variability-in-obese-children
#5
Christoph Baumann, Ulla Rakowski, Reiner Buchhorn
Obese children and adolescents are at high risk of developing cardiovascular diseases later in life. We hypothesized that cardiovascular prophylaxis with omega-3 fatty acids could benefit them. In our study, 20 children and adolescents (mean body mass index percentile: 99.1; mean age: 11.0 years) underwent two ambulatory 24 h Holter electrocardiography (ECG) recordings (before and after at least 3 months of omega-3 fatty acid supplementation). Time domain heart rate variability (HRV) and heart rate (HR) were examined for these patients...
2018: International Journal of Pediatrics
https://www.readbyqxmd.com/read/29681241/differences-in-the-health-transition-patterns-of-migrants-and-non-migrants-aged-50-and-older-in-southern-and-western-europe-2004-2015
#6
Matias Reus-Pons, Clara H Mulder, Eva U B Kibele, Fanny Janssen
BACKGROUND: Most previous research on migrant health in Europe has taken a cross-sectional perspective, without a specific focus on the older population. Having knowledge about inequalities in health transitions over the life course between migrants and non-migrants, including at older ages, is crucial for the tailoring of policies to the demands of an ageing and culturally diverse society. We analyse differences in health transitions between migrants and non-migrants, specifically focusing on the older population in Europe...
April 23, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29681051/voluminous-urethral-stone-a-very-rare-complication-after-male-suburethral-sling-surgery-as-a-result-of-sling-erosion-into-proximal-urethra
#7
Ioan Scarneciu, Cristian Andrei, Camelia Scarneciu, Aura Mihaela Lupu, Ovidiu Gabriel Bratu, Sorin Lupu
Male sling for urinary incontinence is usually accompanied by very good results, with a small number of complications,but, when appear, they may be redundant. Voluminous urethral stone developed on suburethral sling as a result of sling erosion into the proximal urethra is an extremely rare complication (following the analysis of cases published on the internet, the authors of this article no longer identified another similar case). We present the case of a patient who presented in our clinic for severe and permanent urinary incontinence, perineal discomfortand pain that was influenced by position...
April 21, 2018: Urology Journal
https://www.readbyqxmd.com/read/29680699/the-additive-effect-of-adherence-to-multiple-healthy-lifestyles-on-subclinical-atherosclerosis-insights-from-the-awhs
#8
Irina Uzhova, Rocio Mateo-Gallego, Belén Moreno-Franco, Esther Molina-Montes, Montserrat Leon-Latre, José A Casasnovas Lenguas, Fernando Civeira, José L Peñalvo
BACKGROUND: Public health strategies targeting multiple healthy behaviors, rather than individual factors, have been proposed as more efficient strategies to promote cardiovascular health. However, the additive effect of multiple targets on primary prevention has not been fully characterized. OBJECTIVE: To examine how adherence to multiple healthy behaviors is associated with the presence of subclinical atherosclerosis, a measure of early cardiovascular disease...
March 28, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29680588/tree-nut-allergens
#9
Sabine Geiselhart, Karin Hoffmann-Sommergruber, Merima Bublin
Tree nuts are considered as part of a healthy diet due to their high nutritional quality. However, they are also a potent source of allergenic proteins inducing IgE mediated hypersensitivity often causing serious, life-threatening reactions. The reported prevalence of tree nut allergy is up to 4.9% worldwide. The general term "tree nuts" comprises a number of nuts, seeds, and drupes, derived from trees from different botanical families. For hazelnut and walnut several allergens have been identified which are already partly applied in component resolved diagnosis, while for other tree nuts such as macadamia, coconut, and Brazil nut only individual allergens were identified and data on additional allergenic proteins are missing...
April 18, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29680420/restless-legs-syndrome-is-associated-with-major-comorbidities-in-a-population-of-danish-blood-donors
#10
Maria Didriksen, Richard P Allen, Brendan J Burchell, Lise W Thørner, Andreas S Rigas, Emanuele Di Angelantonio, Maria H Nielsen, Poul J Jennum, Thomas Werge, Christian Erikstrup, Ole B Pedersen, Kaspar Nielsen, Mie T Bruun, Kristoffer S Burgdorf, Erik Sørensen, Henrik Ullum
BACKGROUND: Restless Legs Syndrome (RLS) is characterized by uncomfortable nocturnal sensations in the legs making sedentary activities and sleep difficult, and is thus linked with psychosocial distress. Due to the symptomatology and neurobiology of RLS (disrupting brain iron and dopamine) it is likely that RLS associates with poorer health-related quality of life (HRQL) and depressive disorder. The objective of this study was to investigate the RLS-HRQL and the RLS-depressive disorder links in a generally healthy population that is not biased by medications...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29679898/heart-rate-variability-alterations-in-late-life-depression-a-meta-analysis
#11
REVIEW
Lydia Brown, Chandan Karmakar, Richard Gray, Ripu Jindal, Terrence Lim, Christina Bryant
OBJECTIVE: There is strong evidence for a bi-directional relationship between heart-health and depression in later life, but the physiological mechanisms underlying this relationship remain unclear. Heart rate variability is one promising factor that might help explain this relationship. We present results of a meta-analysis that considers heart rate variability alterations in older adults with depression. METHODS: Literature search of Embase, PsychInfo and Medline revealed five clinical studies and six observational studies that examined the relationship between heart rate variability and depression in adults with a mean age over 60...
April 10, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29678972/to-work-despite-chronic-health-conditions-a-qualitative-study-of-workers-at-the-swedish-public-employment-service
#12
Carina Hjärtström, Annika Lindahl Norberg, Gun Johansson, Theo Bodin
OBJECTIVES: Achieving a sustainable, healthy and long working life is key prerequisite for meeting the demographic challenge posed by an ageing population so that more people can work on into their later years. The objective of this study is to explore the relationship between work and chronic health conditions in a group of employees aged 50-64 years with a focus on factors that enable them to continue to work. METHODS: Ten white-collar workers with one or more chronic health conditions at the Swedish Public Employment Service participated in the study...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678807/digital-inequalities-in-the-use-of-self-tracking-diet-and-fitness-apps-interview-study-on-the-influence-of-social-economic-and-cultural-factors
#13
Faustine Régnier, Louis Chauvel
BACKGROUND: Digital devices are driving economic and social transformations, but assessing the uses, perceptions, and impact of these new technologies on diet and physical activity remains a major societal challenge. OBJECTIVE: We aimed to determine under which social, economic, and cultural conditions individuals in France were more likely to be actively invested in the use of self-tracking diet and fitness apps for better health behaviors. METHODS: Existing users of 3 diet and fitness self-tracking apps (Weight Watchers, MyFitnessPal, and sport apps) were recruited from 3 regions of France...
April 20, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29678425/myopericytoma-of-the-base-of-the-finger-radiological-and-pathological-description-of-a-rare-benign-entity
#14
Laurent Van Camp, Jean Goubau, Ivo Van den Berghe, Koen Mermuys
A previously healthy 46-year-old woman presented with a mass lesion between the bases of the fourth and fifth fingers of the right hand. The mass had grown progressively over 2 years and started to cause practical difficulties in everyday life. Imaging depicted a hypervascular and well-circumscribed soft tissue tumor with imaging characteristics of a sarcoma. The lesion was treated surgically. The final diagnosis of the specimen upon pathology was a myopericytoma, a benign smooth-muscle cell neoplasm. Myopericytoma is a rare disease entity; however, it is important because it can mimic more ominous conditions...
April 17, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29678409/phototherapy-for-neonatal-hyperbilirubinemia-and-childhood-eczema-rhinitis-and-wheeze
#15
Elizabeth Huiwen Tham, Evelyn Xiu Ling Loo, Anne Goh, Oon Hoe Teoh, Fabian Yap, Kok Hian Tan, Keith M Godfrey, Hugo Van Bever, Bee Wah Lee, Yap Seng Chong, Lynette Pei-Chi Shek
BACKGROUND: The pathogenesis of allergic diseases in childhood may be attributed to influences of early environmental stimuli on fetal and neonatal immune regulation. Neonatal hyperbilirubinemia is common in the Asian population and up to 20% of infants require phototherapy. We examined the hypothesis that phototherapy for neonatal hyperbilirubinemia modulates the infant's risk of developing eczema, rhinitis and wheeze in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort...
March 24, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29678224/evaluation-of-the-mucosal-inflammatory-responses-to-equine-cyathostomins-in-response-to-anthelmintic-treatment
#16
A E Steuer, A T Loynachan, M K Nielsen
Members of Cyathostominae are pervasive parasites of equids that can cause larval cyathostominosis, a potentially life-threatening disease that occurs when a multitude of encysted larvae synchronously excyst from the wall of the large intestine. Moxidectin and fenbendazole are the two current labeled drugs that target the encysted larval stages; however, there is limited knowledge of the local inflammatory response to the larvae and to the two treatments in clinically healthy horses. This study is the first to evaluate the local inflammatory response to cyathostomin larvae and to larvicidal treatment at 2 and 5 weeks post treatment...
May 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29677680/transcriptomic-identification-of-salt-related-genes-and-de-novo-assembly-in-common-buckwheat-f-esculentum
#17
Qi-Huan Lu, Ya-Qi Wang, Jin-Nan Song, Hong-Bing Yang
Common buckwheat (F. esculentum), annually herbaceous crop, is prevalent in people's daily life with the increasing development of economics. Compared with wheat, it is highly praised with high content of rutin and flavonoid. Common buckwheat is recognized as healthy food with good taste, and the product price of which such as noodles, flour, bread and so on are higher than wheat, and the seeds of which are bigger than that of tartary buckwheat, so if common buckwheat are planted more widely, people will spend less money on this healthy and delicious food...
April 4, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29676707/-ultrasound-guided-surgery-for-breast-cancer
#18
J H Volders, N M H Krekel, M H Haloua, S Meijer, M P van den Tol
Recent literature shows that perioperative ultrasound guidance of surgery for palpable and nonpalpable breast carcinoma results in improved surgical effectiveness. Ultrasound-guided surgery can easily lead to significant improvement of the number of radical resections and can decrease the need for additional surgery or extra radiotherapy. Ultrasound-guided surgery also contributes to a reduction in the amount of excessive breast tissue removal, which means the final cosmetic result is better. Ultrasound-guided surgery is cost-effective and easy to learn...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29676503/toward-a-global-geroethics-gerontology-and-the-theory-of-the-good-human-life
#19
Hans-Joerg Ehni, Selma Kadi, Maartje Schermer, Sridhar Venkatapuram
Gerontologists have proposed different concepts for ageing well such as 'successful ageing', 'active ageing', and 'healthy ageing'. These conceptions are primarily focused on maintaining health and preventing disease. But they also raise the questions: what is a good life in old age and how can it be achieved? While medical in origin, these concepts and strategies for ageing well also contain ethical advice for individuals and societies on how to act regarding ageing and old age. This connection between gerontology and ethics is overlooked by both schools of thought...
May 2018: Bioethics
https://www.readbyqxmd.com/read/29675415/practical-and-ethical-aspects-of-advance-research-directives-for-research-on-healthy-aging-german-and-israeli-professionals-perspectives
#20
Perla Werner, Silke Schicktanz
Background: Healthy aging is the development and maintenance of optimal cognitive, social and physical well-being, and function in older adults. Preventing or minimizing disease is one of the main ways of achieving healthy aging. Dementia is one of the most prevalent and life-changing diseases of old age. Thus, dementia prevention research is defined as one of the main priorities worldwide. However, conducting research with persons who lack the capacity to give consent is a major ethical issue...
2018: Frontiers in Medicine
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