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https://www.readbyqxmd.com/read/28441044/pharmacokinetics-and-pharmacodynamics-of-midazolam-following-intravenous-and-intramuscular-administration-to-sheep
#1
Bradley T Simon, Elizabeth M Scallan, Odette O, Lisa Sams Ebner, Michelle N Cerullo, Christelle Follette, Sherry K Cox, Thomas J Doherty, Ignacio Lizarraga
OBJECTIVE To determine the pharmacokinetic and pharmacodynamic effects of midazolam following IV and IM administration in sheep. ANIMALS 8 healthy adult rams. PROCEDURES Sheep were administered midazolam (0.5 mg/kg) by the IV route and then by the IM route 7 days later in a crossover study. Physiologic and behavioral variables were assessed and blood samples collected for determination of plasma midazolam and 1-hydroxymidazolam (primary midazolam metabolite) concentrations immediately before (baseline) and at predetermined times for 1,440 minutes after midazolam administration...
May 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28439220/pediatric-reference-intervals-for-transferrin-saturation-in-the-caliper-cohort-of-healthy-children-and-adolescents
#2
Victoria Higgins, Man Khun Chan, Khosrow Adeli
BACKGROUND: Transferrin saturation reference intervals specific for age and sex have not been previously reported for the pediatric population. The reference values for transferrin saturation have been previously reported to be lower in children compared to adults, caused by a combination of low serum iron and high serum transferrin levels in children, warranting specific reference intervals. Here we use the original iron and transferrin data from the CALIPER cohort to establish age- and sex-specific pediatric reference intervals for transferrin saturation...
March 2017: EJIFCC
https://www.readbyqxmd.com/read/28439072/fecal-microbial-characterization-of-hospitalized-patients-with-suspected-infectious-diarrhea-shows-significant-dysbiosis
#3
Tzipi Braun, Ayelet Di Segni, Marina BenShoshan, Roy Asaf, James E Squires, Sarit Farage Barhom, Efrat Glick Saar, Karen Cesarkas, Gill Smollan, Batia Weiss, Sharon Amit, Nathan Keller, Yael Haberman
Hospitalized patients are at increased risk for acquiring healthcare-associated infections (HAIs) and inadequate nutrition. The human intestinal microbiota plays vital functions in nutrient supply and protection from pathogens, yet characterization of the microbiota of hospitalized patients is lacking. We used 16S rRNA amplicon sequencing to characterize the global pattern of microbial composition of fecal samples from 196 hospitalized patients with suspected infectious diarrhea in comparison to healthy, non-hospitalized subjects (n = 881), and to traditional culture results...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28439059/-calcium-and-bone-metabolism-across-women-s-life-stages-nutritive-therapy-for-improvement-of-bone-and-calcium-metabolism-according-to-life-stage-in-women
#4
Kazuya Makita
Postmenopausal osteoporosis is mainly caused by decreased estrogen levels, and progression of disease is associated with irreversible changes. It is therefore extremely important to maintain or improve healthy bone and calcium metabolism during and before the climacteric from a preventive medicine viewpoint. The specific preventive measures are appropriate calcium intake and regular physical exercise. In recent years, women in their twenties are considerably thinner and have a lower calcium intake than women in other age groups, which may lead to a further increase in the number of women with osteoporosis in the future...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28438320/critical-care-nurses-perceptions-of-the-outcomes-of-working-overtime-in-canada
#5
Vanessa M Lobo, Jenny Ploeg, Anita Fisher, Gladys Peachey, Noori Akhtar-Danesh
BACKGROUND: Nursing overtime is being integrated into the normal landscape of practice to ensure optimal staffing levels and addresses variations in patient volume and acuity. This is particularly true in critical care where fluctuations in either are difficult to predict. PURPOSE: The goal of this study was to explore critical care nurses' perceptions of the outcomes of working overtime. METHODS: Sally Thorne's interpretive description guided the collection and analysis of data...
January 7, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28438275/psychophysical-health-status-of-breast-cancer-survivors-and-effects-of-12-weeks-of-aerobic-training
#6
Andrea Di Blasio, Teresa Morano, Ettore Cianchetti, Sabina Gallina, Ines Bucci, Serena Di Santo, Camilla Tinari, Francesco Di Donato, Pascal Izzicupo, Angela Di Baldassarre, Alessandra Cimini, Giorgio Napolitano
The aim of this study was to analyse the health status of breast cancer survivors and the effects of 12 weeks of aerobic training. Twenty-three breast cancer survivors (51.71 ± 3.17 years) and 23 healthy women (50.73 ± 2.97 years) were investigated for body composition, daily physical activity, quality of life, salivary cortisol, and DHEA-S. Breast cancer survivors were then aerobically trained for 12 weeks. Breast cancer survivors have a worse psychophysical health than healthy women. Aerobic training increased salivary DHEA-S, aerobic fitness, self-reported health, and nocturnal sleeping time and reduced salivary cortisol in breast cancer survivors...
May 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28438246/does-dual-task-coordination-performance-decline-in-later-life
#7
María V Sebastián, Roberto Mediavilla
BACKGROUND: This cross-sectional study examined whether changes occur in people’s capacity to coordinate two simultaneous tasks (dual-task) when transitioning from adulthood to later life. The central executive, Baddeley’s working memory model component, is responsible for this coordination. Contradictory results have been reported regarding the relationship between ageing and dual-task performance; but these seem to be related to methodological issues that have been addressed in this study...
May 2017: Psicothema
https://www.readbyqxmd.com/read/28438198/health-related-quality-of-life-in-dutch-infants-toddlers-and-young-children
#8
S A Schepers, H A van Oers, H Maurice-Stam, J Huisman, C M Verhaak, M A Grootenhuis, L Haverman
BACKGROUND: The purpose of this study is to provide Dutch normative data and to assess internal consistency and known-groups validity for the TNO AZL Preschool Children Quality of Life (TAPQOL) and the acute version of the generic Pediatric Quality of Life Inventory (PedsQL 4.0) in Dutch young children aged 0-7 years. METHODS: Participants were selected from a panel of a large Dutch market research agency. A sample of 794 parents (response rate 61%, 39% fathers) of children (53% boys) from the general Dutch population, completed an electronic version of the TAPQOL (N = 227 infants aged 0-1 years) or PedsQL 4...
April 24, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28438051/similarity-of-female-central-hypogonadotropic-hypogonadism-and-postmenopause
#9
I Ilovayskaya, V Zektser, L Lazebnik
OBJECTIVES: Central (hypogonadotropic) hypogonadism in women could be a cause of persistent amenorrhea and hypoestrogenemia as observed in postmenopause. This study aimed to compare the clinical, hormonal and biochemical features in women with non-physiological (central hypogonadism) and physiological (postmenopause) hypoestrogenemia. METHODS: A total of 161 young women, median age 24.9 years (interquartile range (IQR) 21.2; 30.5) with central hypogonadism (with isolated hypogonadotropic hypogonadism, n = 76, and with hypopituitarism, n = 85), 53 healthy young women, median age 23...
April 24, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28437567/people-with-patellofemoral-oa-walk-with-different-pelvic-and-hip-kinematics-compared-to-healthy-aged-matched-controls
#10
Kay M Crossley, Anthony G Schache, Hannah Ozturk, Jonathan Lentzos, Melissa Munanto, Marcus G Pandy
Objective, Patellofemoral joint (PFJ) osteoarthritis (OA) is common, yet little is known about how this condition influences lower-limb biomechanical function. This study compared pelvis and lower-limb kinematics in people with and without PFJOA., Methods, Sixty-nine participants (64% women, mean age 56±10 years) with anterior knee pain aggravated by PFJ loaded activities (stair ambulation, rising from sitting, squatting) and radiographic lateral PFJOA on skyline radiographs were compared with 18 controls (78% women, mean age 53±7 years) with no lower-limb pain or radiographic OA...
April 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28437149/the-effects-of-yoga-on-positive-mental-health-among-healthy-adults-a-systematic-review-and-meta-analysis
#11
Tom Hendriks, Joop de Jong, Holger Cramer
OBJECTIVES: The aim of this study was to present an overview of the research on the effects of yoga on positive mental health (PMH) among non-clinical adult populations. METHODS: This was a systematic literature review and meta-analysis, including a risk of bias assessment. The electronic databases PubMed/Medline, Scopus, IndMED, and the Cochrane Library were searched from 1975 to 2015. Randomized controlled trials (RCTs) on the effects of yoga interventions on PMH among a healthy adult population were selected...
February 28, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28437143/motivations-for-botanical-use-by-socioeconomically-diverse-urban-adults-does-evidence-support-motivation
#12
Grace F Duffy, Emily Stave Shupe, Marie Fanelli Kuczmarski, Alan B Zonderman, Michele K Evans
OBJECTIVE: The study objectives were to characterize botanical dietary supplement (BDS) use and to compare the motivations for botanical supplement (BS) use to the efficacy of the botanical in a socioeconomically and racially diverse urban adult population. METHODS: Subjects were from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study, a 20-year prospective health disparities study with African American and white adults from Baltimore, Maryland...
February 16, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28436712/disposition-and-metabolism-of-14-c-galunisertib-a-tgf-%C3%AE-ri-kinase-alk5-inhibitor-following-oral-administration-in-healthy-subjects-and-mechanistic-prediction-of-the-effect-of-itraconazole-on-galunisertib-pharmacokinetics
#13
Kenneth C Cassidy, Ivelina Gueorguieva, Colin Miles, Jessica Rehmel, Ping Yi, William J Ehlhardt
The disposition and metabolism of galunisertib (LY2157299 monohydrate, a TGF-βRI Kinase/ALK5 Inhibitor) was characterized following a single oral dose of 150 mg of [(14)C]-galunisertib (100 µCi) to six healthy human subjects. The galunisertib plasma half-life was 8.6 h, while the (14)C half-life was 10.0 h. Galunisertib was abundant in circulation (40.3% of the (14)C AUC0-24h), with 7 additional metabolites detected in plasma. Two metabolites LSN3199597 (M5, mono-oxidation), and M4 (glucuronide of M3) were the most abundant circulating metabolites (10...
April 24, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28435933/the-c677t-variant-in-mthfr-modulates-associations-between-brain-integrity-mood-and-cognitive-functioning-in-old-age
#14
Florence F Roussotte, Xue Hua, Katherine L Narr, Gary W Small, Paul M Thompson
INTRODUCTION: The C677T functional variant in the methylene-tetrahydrofolate reductase (MTHFR) gene leads to reduced enzymatic activity and elevated blood levels of homocysteine. Hyperhomocysteinemia has been linked with higher rates of cardiovascular diseases, cognitive decline, and late-life depression. METHODS AND MATERIALS: Here, 3D magnetic resonance imaging data was analyzed from 738 individuals (age: 75.5 ± 6.8 years; 438 men/300 women) including 173 Alzheimer's patients, 359 subjects with mild cognitive impairment, and 206 healthy older adults, scanned as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI)...
April 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28435890/gene-expression-profile-of-human-cytokines-in-response-to-burkholderia-pseudomallei-infection
#15
Shivankari Krishnananthasivam, Harindra Darshana Sathkumara, Enoka Corea, Mohan Natesan, Aruna Dharshan De Silva
Melioidosis is an underreported infectious disease, caused by the Gram-negative bacterium Burkholderia pseudomallei. Understanding the disease susceptibility and pathogenesis is crucial for developing newer diagnostic and therapeutic strategies for this life-threatening infection. In this study, we aimed to analyze the gene expression levels of important cytokines in melioidosis patients and establish useful correlates with disease biomarkers compared to cases of sepsis infection caused by other pathogens and healthy individuals...
March 2017: MSphere
https://www.readbyqxmd.com/read/28435840/microbial-flora-probiotics-bacillus-subtilis-and-the-search-for-a-long-and-healthy-human-longevity
#16
COMMENT
Facundo Rodriguez Ayala, Carlos Bauman, Sebastián Cogliati, Cecilia Leñini, Marco Bartolini, Roberto Grau
Probiotics are live microorganisms that have beneficial effects on host health, including extended lifespan, when they are administered or present in adequate quantities. However, the mechanisms by which probiotics stimulate host longevity remain unclear and very poorly understood. In a recent study (Nat. Commun. 8, 14332 (2017) doi: 10.1038/ncomms14332), we used the spore-forming probiotic bacterium Bacillus subtilis and the model organism Caenorhabditis elegans to study the mechanism by which a probiotic bacterium affects host longevity...
March 16, 2017: Microbial Cell
https://www.readbyqxmd.com/read/28435275/pathogenic-beliefs-among-patients-with-depressive-disorders
#17
Adam Neelapaijit, Tinakon Wongpakaran, Nahathai Wongpakaran, Kulvadee Thongpibul
INTRODUCTION: Pathogenic belief is a central construct within control-mastery theory, which is an integrated dynamic-cognitive-relational approach in psychotherapy. Pathogenic beliefs result from traumatic life experiences and are considered the root of any psychological disorders presented clinically. Nevertheless, how and what type of pathogenic beliefs are attributed to clinical depressive disorder is unknown. The present study aimed to examine this issue. PATIENTS AND METHODS: Thirty patients with depressive disorder, who came for psychotherapy at a psychotherapy clinic, were matched based on age and gender with healthy controls who were medical students...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28435218/pharmacokinetics-and-safety-of-olopatadine-hydrochloride-0-77-in-healthy-subjects-with-asymptomatic-eyes-data-from-2-independent-clinical-studies
#18
Edward Meier, Abhijit Narvekar, Ganesh R Iyer, Harvey B DuBiner, Apinya Vutikullird, David Wirta, Kenneth Sall
PURPOSE: To assess the pharmacokinetics and safety of hydrochloride ophthalmic solution 0.77% olopatadine from 2 independent (Phase I and Phase III, respectively) clinical studies in healthy subjects. MATERIALS AND METHODS: The Phase I, multicenter, randomized (2:1), vehicle-controlled study was conducted in subjects ≥18 years old (N=36) to assess the systemic pharmacokinetics of olopatadine 0.77% following single- and multiple-dose exposures. The Phase III, multicenter, randomized (2:1), vehicle-controlled study was conducted in subjects ≥2 years old (N=499) to evaluate long-term ocular safety of olopatadine 0...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28434806/fibronectin-adherent-peripheral-blood-derived-mononuclear-cells-as-paclitaxel-carriers-for-glioblastoma-treatment-an-in-vitro-study
#19
Marco Paolo Schiariti, Francesco Restelli, Paolo Ferroli, Anna Benetti, Angiola Berenzi, Anna Ferri, Valentina Ceserani, Emilio Ciusani, Moris Cadei, Gaetano Finocchiaro, Augusto Pessina, Eugenio Parati, Roberto Pallini, Giulio Alessandri
BACKGROUND: Glioblastoma (GBM) represents the most aggressive malignant brain tumor in adults, with a risible median life expectancy despite gold standard treatment. Novel drug-delivery methods have been explored. Here we evaluated the possibility to use mononuclear cells (MCs) belonging to the monocytic-dendritic lineage as drug-carrier. METHODS: MCs were obtained from 10 patients harboring a GBM, and from healthy volunteers, considered as controls. GBM tissue was also obtained from patients...
April 20, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28434208/dietary-interventions-for-adults-with-chronic-kidney-disease
#20
REVIEW
Suetonia C Palmer, Jasjot K Maggo, Katrina L Campbell, Jonathan C Craig, David W Johnson, Bernadet Sutanto, Marinella Ruospo, Allison Tong, Giovanni Fm Strippoli
BACKGROUND: Dietary changes are routinely recommended in people with chronic kidney disease (CKD) on the basis of randomised evidence in the general population and non-randomised studies in CKD that suggest certain healthy eating patterns may prevent cardiovascular events and lower mortality. People who have kidney disease have prioritised dietary modifications as an important treatment uncertainty. OBJECTIVES: This review evaluated the benefits and harms of dietary interventions among adults with CKD including people with end-stage kidney disease (ESKD) treated with dialysis or kidney transplantation...
April 23, 2017: Cochrane Database of Systematic Reviews
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