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https://www.readbyqxmd.com/read/29223681/language-processing-in-age-related-macular-degeneration-associated-with-unique-functional-connectivity-signatures-in-the-right-hemisphere
#1
Jie Zhuang, David J Madden, Xuan Duong-Fernandez, Nan-Kuei Chen, Scott W Cousins, Guy G Potter, Michele T Diaz, Heather E Whitson
Age-related macular degeneration (AMD) is a retinal disease associated with significant vision loss among older adults. Previous large-scale behavioral studies indicate that people with AMD are at increased risk of cognitive deficits in language processing, particularly in verbal fluency tasks. The neural underpinnings of any relationship between AMD and higher cognitive functions, such as language processing, remain unclear. This study aims to address this issue using independent component analysis of spontaneous brain activity at rest...
November 14, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29223444/association-of-vedolizumab-level-anti-drug-antibodies-and-%C3%AE-4%C3%AE-7-occupancy-with-response-in-patients-with-inflammatory-bowel-diseases
#2
Bella Ungar, Uri Kopylov, Miri Yavzori, Ella Fudim, Orit Picard, Adi Lahat, Daniel Coscas, Matti Waterman, Ola Haj-Natour, Noam Orbach-Zingboim, Ren Mao, Minhu Chen, Yehuda Chowers, Rami Eliakim, Shomron Ben-Horin
BACKGROUND & AIMS: There are few data available on the real-life pharmacokinetic and pharmacodynamics features of vedolizumab, a monoclonal antibody against integrin α4β7. We performed a prospective study of patients with inflammatory bowel diseases (IBD) treated with vedolizumab to determine serum drug concentrations, formation of anti-vedolizumab antibodies (AVAs), and integrin α4β7 saturation. METHODS: We performed a prospective study of 106 patients with IBD (67 with Crohn's disease and 39 with ulcerative colitis) treated with vedolizumab from September 2014 through March 2017 at 2 tertiary medical centers in Israel...
December 6, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29223177/well-being-and-distress-of-patients-with-parkinson-s-disease-a-comparative-investigation
#3
Francesca Vescovelli, Daniele Sarti, Chiara Ruini
BACKGROUND: Psychological resources, such as psychological well-being (PWB) and life satisfaction (LS) can aid individuals suffering from chronic illnesses to cope with their illness. The aim of this study was to investigate PWB, LS, quality of life (QoL), and distress in patients with Parkinson's disease (PD) and to compare them with healthy controls. METHODS: One hundred and thirteen individuals were recruited. Fifty of the participants suffered from PD, while 53 individuals reported other non-neurological diseases...
December 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29222887/relationship-between-umami-taste-acuity-with-sweet-or-bitter-taste-acuity-and-food-selection-in-japanese-women-university-students
#4
Masaru Kubota, Chikako Toda, Ayako Nagai-Moriyama
BACKGROUND AND OBJECTIVES: Although there are many studies on the umami receptor and its signaling pathway, literature on the effect of umami taste acuity on dietary choices in healthy subjects is limited. The current study aims to clarify the relationship between umami taste acuity with sweet or bitter taste acuity, food preference and intake. METHODS AND STUDY DESIGN: Forty-two healthy Japanese female university students were enrolled. The acuity for umami, sweet, and bitter tastes was evaluated using the filter-paper disc method...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222266/impact-of-bone-disease-and-pain-in-thalassemia
#5
REVIEW
Antonio Piga
Conventional treatment of thalassemia, namely regular blood transfusion and iron chelation, improves perspectives and quality of life; however, successful treatment leads to more time in which long-term complications such as bone disease can develop. Thalassemia bone disease (TBD) is unique: all aspects, from bone anatomy and bone quality to mineral density, may be affected, with important morbidity including osteoporosis, fractures, spinal deformities, nerve compression, and pain. Clinical presentations include growth impairment, rickets-like features, back pain, spinal deformities, any sign of nerve compression, severe osteoporosis, and fragility fractures...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222243/treatment-free-remission-in-cml-who-how-and-why
#6
REVIEW
Francois-Xavier Mahon
Chronic myeloid leukemia (CML) is the best example of successful targeted therapy. Today, the overall survival of patients with CML treated by using tyrosine kinase inhibitors (TKIs) is very close to that of the healthy population. The current question is: how can we further ameliorate the clinical outcome of patients with CML? Clinical trials have shown that some patients with CML in the chronic phase who achieve sustained deep molecular responses on TKI therapy can safely suspend therapy with no evidence of relapse...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29221919/impact-of-lifestyle-interventions-targeting-healthy-diet-physical-activity-and-weight-loss-on-asthma-in-adults-what-is-the-evidence
#7
Sharmilee M Nyenhuis, Anne E Dixon, Jun Ma
Unhealthy lifestyle factors such as poor diet quality, sedentary lifestyle, and obesity are associated with negative health consequences in asthma including poor asthma control, impaired quality of life, and greater health care utilization. Lifestyle modification is the cornerstone of behavioral treatments and has been effective in chronic diseases such as atherothrombotic vascular disease and diabetes. There is a critical need for lifestyle interventions in asthma care that address obesity and its intimately linked risk behaviors in terms of poor diet and physical inactivity...
December 5, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29221833/giving-others-the-option-of-choice-an-fmri-study-on-low-cost-cooperation
#8
Imke L J Lemmers-Jansen, Lydia Krabbendam, David M Amodio, Niels J Van Doesum, Dick J Veltman, Paul A M Van Lange
Successful social relationships require a consideration of a partner's thoughts and intentions. This aspect of social life is captured in the social mindfulness paradigm (SoMi task), in which participants make decisions that either limit or preserve options for their interaction partner's subsequent choice. Here we investigated the neural correlates of spontaneous socially mindful and unmindful behaviours. Functional magnetic resonance data were acquired from 47 healthy adolescents and young adults (age 16-27) as they completed the SoMi task...
December 5, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29221763/cognitive-impairment-and-quality-of-life-of-people-with-epilepsy-and-neurocysticercosis-in-zambia
#9
Anne L Nau, Kabemba E Mwape, Jasmin Wiefek, Kathie Schmidt, Emmanuel Abatih, Pierre Dorny, Nicolas Praet, Clarance Chiluba, Holger Schmidt, Isaac K Phiri, Andrea S Winkler, Sarah Gabriël, Joachim Blocher
Cognitive impairment and quality of life (Qol) are important to assess the burden of epilepsy and neurocysticercosis (NCC), which are common but neglected in Sub-Saharan Africa (SSA). The aims of this study were to assess cognitive performance and Qol of people with epilepsy (PWE) in Zambia and to explore differences in PWE with and without NCC. In this community based, cross-sectional case-control-study, 47 PWE and 50 healthy controls completed five neuropsychological tests (Mini Mental State Examination (MMSE), Digit Span, Selective Reminding Test (SRT), Spatial Recall Test (SPART), Test Battery of Attentional Performance (TAP)) and a World Health Organization (WHO) questionnaire of Qol...
December 5, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29221518/measuring-healthy-lifestyle-and-mental-health-indicators-in-south-asian-women-using-the-your-health-quality-of-life-and-well-being-questionnaire
#10
Nida Ahmed, Sabahat Ahmed, Zartasht Carmichael, Amtul Salam Sami
INTRODUCTION: Health is a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity. A literature review has revealed that there is no specific questionnaire available to assess well-being within the community. METHODS: Fifty South Asian women were randomly selected to complete the "Your Health: Quality of Life and Well-being Questionnaire" assessing diet, lifestyle, and mental health among others. Data from the questionnaires was extracted and participants were categorised based on these findings...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29220621/quality-of-life-in-australian-adults-aged-50-years-and-over-data-using-the-schedule-for-the-evaluation-of-individual-quality-of-life-seiqol-dw
#11
Sofia Robleda, Nancy A Pachana
OBJECTIVES: This study explored unique and personal domains associated with quality of life (QOL) in 153 mid-aged and older Australian adults over age 50, using an innovative measure of individualized QOL, the Schedule for the Evaluation of Individual Quality of Life (SEIQOL-DW). METHODS: Demographic measures as well as the SEIQOL-DW were administered. The qualitative responses on this scale were analyzed by Leximancer, a text analysis program that extracts semantic meaning and relational information automatically from text...
October 27, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29220598/hope-for-the-future-but-fear-the-risk-of-stigma-ethiopian-family-caregivers-lived-experience-of-caring-for-their-hiv-positive-child-two-years-after-starting-antiretroviral-treatment
#12
Mulatu Biru, Pia Lunqvist, Mitikie Molla, Degu Jerene, Inger Hallström
Family caregivers are believed to be the primary source of support for HIV-affected children. There is limited evidence about practices of support for caregivers, to strengthen them and to enhance the welfare of HIV positive children, especially in African settings. Our aim was therefore to illuminate caregivers' lived experiences of caring for a child in Ethiopia 2 years after the child was enrolled in antiretroviral therapy. Qualitative interviews with 18 family caregivers of 18 children were performed and analyzed using an inductive design with a hermeneutic phenomenological approach...
December 8, 2017: Comprehensive Child and Adolescent Nursing
https://www.readbyqxmd.com/read/29219149/global-aetiology-and-epidemiology-of-type-2-diabetes-mellitus-and-its-complications
#13
REVIEW
Yan Zheng, Sylvia H Ley, Frank B Hu
Globally, the number of people with diabetes mellitus has quadrupled in the past three decades, and diabetes mellitus is the ninth major cause of death. About 1 in 11 adults worldwide now have diabetes mellitus, 90% of whom have type 2 diabetes mellitus (T2DM). Asia is a major area of the rapidly emerging T2DM global epidemic, with China and India the top two epicentres. Although genetic predisposition partly determines individual susceptibility to T2DM, an unhealthy diet and a sedentary lifestyle are important drivers of the current global epidemic; early developmental factors (such as intrauterine exposures) also have a role in susceptibility to T2DM later in life...
December 8, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29219078/systematic-review-of-the-relationships-between-sleep-duration-and-health-indicators-in-the-early-years-0-4%C3%A2-years
#14
Jean-Philippe Chaput, Casey E Gray, Veronica J Poitras, Valerie Carson, Reut Gruber, Catherine S Birken, Joanna E MacLean, Salomé Aubert, Margaret Sampson, Mark S Tremblay
BACKGROUND: The objective of this systematic review was to examine for the first time the associations between sleep duration and a broad range of health indicators in children aged 0 to 4 years. METHODS: Electronic databases were searched with no limits on date or study design. Included studies (published in English or French) were peer-reviewed and met the a priori determined population (apparently healthy children aged 1 month to 4.99 years), intervention/exposure/comparator (various sleep durations), and outcome criteria (adiposity, emotional regulation, cognitive development, motor development, growth, cardiometabolic health, sedentary behaviour, physical activity, quality of life/well-being, and risks/injuries)...
November 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29219008/powered-off-road-wheelchair-for-the-transportation-of-tetraplegics-along-mountain-trails
#15
Michele Gabrio Antonelli, Stefano Alleva, Pierluigi Beomonte Zobel, Francesco Durante, Terenziano Raparelli
PURPOSE: For off-road mobility, some manual or power assisted devices were conceived to be self-driven by paraplegics while for tetraplegics non power-assisted devices were conceived. These devices require one or more conductors who are subjected to a high physical demand thus potentially creating: precarious safety condition for the user an elevated physical demand of conductors could reduce the care and the attention to give to the user; the time of the outdoor adventure experience of the user could be limited...
December 8, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29218698/risk-factors-of-overactive-bladder-syndrome-and-its-relation-to-sexual-function-in-menopausal-women
#16
Sevil Hakimi, Elham Aminian, Sakineh Mohammad- Alizadeh Charandabi, Parvin Bastani, Marzieh Mohammadi
BACKGROUND: Overactive bladder syndrome is a common and annoying complication worldwide that could negatively affect the quality of life of afflicted individuals. We aimed to determine the prevalence and risk factors of overactive bladder syndrome and its relation to sexual function in healthy menopausal women. METHODS: This cross-sectional study was done on 340 women aged 45-60 years in Tabriz, northwest Iran, during 2015-2016. Data were collected using a demographic data questionnaire, the Overactive Bladder Syndrome Score, and the McCoy Female Sexuality Questionnaire...
December 4, 2017: Urologia
https://www.readbyqxmd.com/read/29218111/the-diagnostic-value-of-microrna-4787-5p-and-microrna-4306-in-patients-with-acute-aortic-dissection
#17
Lei Wang, Shijie Zhang, Zhigao Xu, Jingjing Zhang, Li Li, Guoqiang Zhao
Acute aortic dissection (AAD) is a life-threatening cardiovascular disease with the high morbidity and mortality. Imaging modalities are the gold standard for the diagnosis of AAD; however, they are not always available in emergency department. Biomarker-assisted diagnosis is important for the early treatment of AAD. The aim of the present study was to identify potential microRNA (miRNA) biomarkers for AAD. Differentially expressed plasma miRNAs between AAD patients and age-matched healthy volunteers were analyzed by miRNA microarray...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29218067/perceived-age-and-life-style-the-specific-contributions-of-seven-factors-involved-in-health-and-beauty
#18
Victor Gabriel Clatici, Daniel Racoceanu, Claude Dalle, Cristiana Voicu, Lucia Tomas-Aragones, Servando E Marron, Uwe Wollina, Simona Fica
OBJECTIVES: The skin is a dynamic, visible organ, showing the most obvious signs of aging. The mechanisms of extrinsic aging, most of them presented in this paper, are currently well known and also the only ones that can be counteracted. Therefore, the transition of this knowledge in the general population is of the most importance, in order to introduce healthy aging strategies, to prevent the development of chronic or malignant diseases and psychological burden related to old age. MATERIALS AND METHODS: A thorough review of the literature has been performed in order to identify the main factors involved in skin health and aging...
September 2017: Mædica
https://www.readbyqxmd.com/read/29216792/quadriceps-muscle-thickness-changes-in-patients-with-aneurysmal-subarachnoid-hemorrhage-during-the-acute-phase
#19
Masafumi Nozoe, Masashi Kanai, Hiroki Kubo, Miki Kobayashi, Miho Yamamoto, Shinichi Shimada, Kyoshi Mase
Background Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening condition that often leads to severe disability in relatively young and healthy people. This disability is physical in many aSAH survivors, so muscle dysfunction may be an important factor in the functional level of these patients. Thus, measuring muscle thickness represents a suitable method for determining muscle function in patients with acute aSAH, because the disordered consciousness often experienced during the acute phase causes active movement to be difficult for these patients...
December 8, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29216784/evaluation-of-peripheral-serotonin-content-and-%C3%AE-2-adrenergic-receptor-function-as-potential-markers-for-life-long-recurrent-depressive-disorder-by-using-methodological-improvements
#20
Boris Aleksovski, Antoni Novotni, Viktorija Vujović, Vladimir Rendevski, Nensi Manusheva, Violeta Neceva, Ana Filipce, Aleksandar Risteski, Vasko Aleksovski, Icko Gjorgoski
OBJECTIVE: We aimed to evaluate the role and the relations between peripheral platelet serotonin content, blood plasma serotonin concentration and the function of platelet α2-adrenergic receptors (α2-AR) as potential state or trait biomarkers for recurrent depressive disorder (RDD). METHODS: 26 drug-free patients with life-long RDD and 31 healthy controls were included in the study. Several methodological improvements in blood collection and platelet isolation were implemented following the present standards in Haematology and Light transmission aggregometry...
December 7, 2017: International Journal of Psychiatry in Clinical Practice
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