keyword
https://read.qxmd.com/read/38479411/safety-efficacy-and-outcome-of-rotational-thrombectomy-assisted-endovascular-revascularisation-of-the-superior-mesenteric-artery-in-acute-thromboembolic-mesenteric-ischaemia
#21
JOURNAL ARTICLE
Annette Thurner, Dominik Peter, Giulia Dalla Torre, Sven Flemming, Ralph Kickuth
PURPOSE:  To evaluate the efficacy and safety of percutaneous rotational thrombectomy-assisted endovascular revascularization of acute thromboembolic superior mesenteric artery occlusions in acute mesenteric ischemia. MATERIALS AND METHODS:  Fifteen cases of percutaneous rotational thrombectomy- assisted (Rotarex S, BD, USA) revascularization were retrospectively analyzed. The etiology was embolic in 40 % of cases and thrombotic in 60 %...
March 13, 2024: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://read.qxmd.com/read/38474394/current-insights-into-tissue-injury-of-giant-cell-arteritis-from-acute-inflammatory-responses-towards-inappropriate-tissue-remodeling
#22
REVIEW
Dimitris Anastasios Palamidas, Loukas Chatzis, Maria Papadaki, Ilias Gissis, Konstantinos Kambas, Evangelos Andreakos, Andreas V Goules, Athanasios G Tzioufas
Giant cell arteritis (GCA) is an autoimmune disease affecting large vessels in patients over 50 years old. It is an exemplary model of a classic inflammatory disorder with IL-6 playing the leading role. The main comorbidities that may appear acutely or chronically are vascular occlusion leading to blindness and thoracic aorta aneurysm formation, respectively. The tissue inflammatory bulk is expressed as acute or chronic delayed-type hypersensitivity reactions, the latter being apparent by giant cell formation...
February 29, 2024: Cells
https://read.qxmd.com/read/38473007/dynamic-perviousness-predicts-revascularization-success-in-acute-ischemic-stroke
#23
JOURNAL ARTICLE
Gergely Bertalan, Roxane Duparc, Miklos Krepuska, Daniel Toth, Jawid Madjidyar, Patrick Thurner, Tilman Schubert, Zsolt Kulcsar
BACKGROUND: The predictive value of thrombus perviousness in acute ischemic stroke (AIS), as measured by computed tomography (CT), has been intensively studied with conflicting results. In this study, we investigate the predictive potential of the novel concept of dynamic perviousness using three-dimensional (3D) volumetric evaluation of occlusive thrombi. METHODS: The full thrombus volume in 65 patients with a hyperdense artery sign on non-contrast CT (NCCT), who underwent mechanical thrombectomy (MT), was segmented...
March 3, 2024: Diagnostics
https://read.qxmd.com/read/38472957/radiomics-based-prediction-of-collateral-status-from-ct-angiography-of-patients-following-a-large-vessel-occlusion-stroke
#24
JOURNAL ARTICLE
Emily W Avery, Anthony Abou-Karam, Sandra Abi-Fadel, Jonas Behland, Adrian Mak, Stefan P Haider, Tal Zeevi, Pina C Sanelli, Christopher G Filippi, Ajay Malhotra, Charles C Matouk, Guido J Falcone, Nils Petersen, Lauren H Sansing, Kevin N Sheth, Seyedmehdi Payabvash
BACKGROUND: A major driver of individual variation in long-term outcomes following a large vessel occlusion (LVO) stroke is the degree of collateral arterial circulation. We aimed to develop and evaluate machine-learning models that quantify LVO collateral status using admission computed tomography angiography (CTA) radiomics. METHODS: We extracted 1116 radiomic features from the anterior circulation territories from admission CTAs of 600 patients experiencing an acute LVO stroke...
February 23, 2024: Diagnostics
https://read.qxmd.com/read/38472301/risk-factors-for-acute-chest-syndrome-among-children-with-sickle-cell-anemia-hospitalized-for-vaso-occlusive-crises
#25
JOURNAL ARTICLE
Faisal A Alghamdi, Fawaz Al-Kasim, Forat Alshhada, Eatedal Ghareeb, Fauzia R Azmet, Adel Almudaibigh, Lobna Baitalmal, Bedah Alnawfal, Rehab Alluqmani
Sickle cell anemia (SCA) is a globally prevalent inherited condition, with acute chest syndrome (ACS) being one of its most severe complications. ACS frequently leads to hospitalization, requires intensive care unit (ICU) admission, and can even result in death. This study aimed to discern the early indicators of impending ACS in children with SCA who were initially hospitalized due to painful vaso-occlusive crises (VOC). This was a retrospective, case‒control investigation of 120 patients aged 1-14 years seen at the King Saud Medical City in Riyadh, Saudi Arabia from January 2021 to December 2022...
March 12, 2024: Scientific Reports
https://read.qxmd.com/read/38471827/technical-risk-stratification-nomogram-model-for-90-day-mortality-prediction-in-patients-with-acute-basilar-artery-occlusion-undergoing-endovascular-thrombectomy-a-multicenter-cohort-study
#26
JOURNAL ARTICLE
Heng Ni, Linbo Zhao, Xinghua Ma, Penghua Lv, Yasuo Ding, Zhensheng Liu, Haibin Shi, Sheng Liu
BACKGROUND: This study aimed to establish and validate a nomogram model for predicting 90-day mortality in patients with acute basilar artery occlusion receiving endovascular thrombectomy. METHODS AND RESULTS: A total of 242 patients with basilar artery occlusion undergoing endovascular thrombectomy were enrolled in our study, in which 172 patients from 3 stroke centers were assigned to the training cohort, and 70 patients from another center were assigned to the validation cohort...
March 12, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38471762/prolonged-venous-transit-on-perfusion-imaging-is-associated-with-higher-odds-of-mortality-in-successfully-reperfused-patients-with-large-vessel-occlusion-stroke
#27
JOURNAL ARTICLE
Vivek S Yedavalli, Manisha Koneru, Meisam Hoseinyazdi, Cynthia Greene, Dhairya A Lakhani, Risheng Xu, Licia P Luna, Justin M Caplan, Adam A Dmytriw, Adrien Guenego, Jeremy J Heit, Gregory W Albers, Max Wintermark, L Fernando Gonzalez, Victor C Urrutia, Judy Huang, Kambiz Nael, Richard Leigh, Elisabeth B Marsh, Argye E Hillis, Rafael H Llinas
BACKGROUND: Poor venous outflow (VO) profiles are associated with unfavorable outcomes in patients with acute ischemic stroke caused by large vessel occlusion (AIS-LVO), despite achieving successful reperfusion. The objective of this study is to assess the association between mortality and prolonged venous transit (PVT), a novel visual qualitative VO marker on CT perfusion (CTP) time to maximum (Tmax) maps. METHODS: We performed a retrospective analysis of prospectively collected data from consecutive adult patients with AIS-LVO with successful reperfusion (modified Thrombolysis in Cerebral Infarction 2b/2c/3)...
March 12, 2024: Journal of Neurointerventional Surgery
https://read.qxmd.com/read/38471696/rationale-and-design-of-treatment-of-acute-ischaemic-stroke-with-edaravone-dexborneol-ii-taste-2-a-multicentre-randomised-controlled-trial
#28
JOURNAL ARTICLE
Chunjuan Wang, Hong-Qiu Gu, Qiang Dong, Anding Xu, Ning Wang, Yi Yang, Feng Wang, Yongjun Wang
BACKGROUND: Edaravone dexborneol is believed to be a novel cytoprotective drug, demonstrating a synergistic combination of antioxidative and anti-inflammatory properties in animal models. The Treatment of Acute Ischaemic Stroke with Edaravone Dexborneol (TASTE) trial demonstrated its superior efficacy over edaravone alone for acute ischaemic stroke (AIS) patients. However, its efficacy in individuals undergoing endovascular therapy (EVT) remains uncertain. AIM: To clarify the rationale and design of the TASTE II (TASTE-2) trial...
March 11, 2024: Stroke and Vascular Neurology
https://read.qxmd.com/read/38471666/left-ventricular-global-longitudinal-strain-and-acute-myocardial-injury-in-patients-with-sickle-cell-disease-admitted-to-the-intensive-care-unit-for-vaso-occlusive-crisis
#29
JOURNAL ARTICLE
Guillaume Roger, Pierre Denormandie, Thibaut Gobe, Danila Azzolina, Tài Pham, Christelle Chantalat, Daphnée Cuveillier, Amir Bouchachi, Patrick Jourdain, Christopher Lai, Arthur Pavot, Nicolas Fage, Paul Domnariu, Jean-Louis Teboul, Xavier Monnet
In patients with sickle cell disease (SCD), SCD-related cardiomyopathy may be partly due to repeated ischaemic events related to sickling during vaso-occlusive crises, but few clinical studies support this hypothesis. We evaluated the incidence of acute myocardial ischaemia during vaso-occlusive crises as assessed by the left ventricular global longitudinal strain (LVGLS) and high-sensitive cardiac troponin T (hs-cTnT). We included adult patients with SCD admitted to the intensive care unit (ICU) for vaso-occlusive crisis...
March 12, 2024: British Journal of Haematology
https://read.qxmd.com/read/38469605/identifying-factors-associated-with-non-mesenterovascular-pathology-in-patients-undergoing-surgical-treatment-for-acute-mesenteric-ischemia
#30
JOURNAL ARTICLE
Mustafa Karaagac, Fatih Dal, Tutkun Talih, Muhammet Akyuz, Erdogan Mutevelli Sozuer, Hizir Yakup Akyildiz
AIM: To identify factors that can help us to avoid a preoperative incorrect diagnosis of vascular occlusion by evaluating patients who underwent laparotomy with a probable preoperative diagnosis of acute mesenteric ischemia (AMI), but later at laparotomy, were diagnosed to have a different pathology than AMI. MATERIAL AND METHODS: A total of 213 patients who were operated with the diagnosis of AMI were enrolled in this study. Based on their operational, clinical, and pathological findings, they were divided into two groups...
2024: Annali Italiani di Chirurgia
https://read.qxmd.com/read/38468466/dihydroergotamine-protects-against-ischemic-stroke-by-modulating-microglial-macrophage-polarization-and-inhibiting-inflammation-in-mice
#31
JOURNAL ARTICLE
Yangmin Zheng, Yue Hu, Feng Yan, Rongliang Wang, Zhen Tao, Junfen Fan, Ziping Han, Haiping Zhao, Ping Liu, Wei Zhuang, Yumin Luo
OBJECTIVES: The search for drugs that can protect the brain tissue and reduce nerve damage in acute ischemic stroke has emerged as a research hotspot. We investigated the potential protective effects and mechanisms of action of dihydroergotamine against ischemic stroke. METHODS: C57BL/6 mice were subjected to middle cerebral artery occlusion (MCAO), and dihydroergotamine at a dose of 10 mg/kg/day was intraperitoneally injected for 14 days. Adhesive removal and beam walking tests were conducted 1, 3, 5, 7, 10, and 14 days after MCAO surgery...
March 11, 2024: Neurological Research
https://read.qxmd.com/read/38466466/the-lncrna-lnc_aabr07044470-1-promotes-the-mitochondrial-damaged-inflammatory-response-to-neuronal-injury-via-mir-214-3p-perm1-axis-in-acute-ischemic-stroke
#32
JOURNAL ARTICLE
Meng Wang, Hong Li, Yulin Qian, Shanshan Zhao, Hao Wang, Yu Wang, Tao Yu
PURPOSE: We investigated the role of lnc_AABR07044470.1 on the occurrence and development of acute ischemic stroke (AIS) and neuronal injury by targeting the miR-214-3p/PERM1 axis to find a novel clinical drug target and prediction and treatment of AIS. METHODS: The mouse AIS animal model was used in vivo experiments and hypoxia/reoxygenation cell model in vitro was established. Firstly, infarction volume and pathological changes of mouse hippocampal neurons were detected using HE staining...
March 11, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38465773/exploring-the-incidence-of-peripheral-arterial-occlusive-disease-following-covid-19-infection-a-retrospective-cohort-study
#33
JOURNAL ARTICLE
Liang-Tsai Yeh, Chi-Ho Chan, Yu-Hsun Wang, Chia-Yi Lee, Shun-Fa Yang, Chao-Bin Yeh
Peripheral arterial occlusive disease (PAOD) is a clinical manifestation of systemic atherosclerosis and is always associated with cerebrovascular disease and various complications. The aim of our study is to evaluate the relationship between the coronavirus disease 2019 (COVID-19) infection and the subsequent PAOD development. A retrospective cohort study was conducted and individuals with COVID-19 infection were identified from the TriNetX analytics platform. A total of 2 206 065 patients with COVID-19 infection and 2 206 065 patients without COVID-19 infection were recruited after exclusion and matching...
March 2024: Journal of Medical Virology
https://read.qxmd.com/read/38463070/paediatric-moyamoya-disease-acute-presentation-with-fever-and-confusion-in-an-8-year-old-a-case-report
#34
Deepika Karki, Prashant Pant, Sandip Paudel, Sumit Kumar Sah, Samiksha Regmi, Sanjeev Bhandari
INTRODUCTION AND IMPORTANCE: Moyamoya is a chronic vaso-occlusive cerebrovascular disorder which involves internal carotid artery and its proximal branches, forming compensatory Moyamoya vessels. It may manifest with diverse symptoms, but early detection is crucial for a favourable prognosis. CASE PRESENTATION: The authors present a case of an 8-year-old child who presented to the emergency with acute onset fever and confusion in speech. Although the symptoms were vague, she was advised for a thorough investigation...
March 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38460777/computed-tomography-perfusion-deficit-volume-predicts-the-functional-outcome-of-endovascular-therapy-for-basilar-artery-occlusion
#35
JOURNAL ARTICLE
Yiying Pan, Pengjun Chen, Shunyang Chen, Yanjun Li, Junhe Wang, Shuiwei Xia, Jie Rao, Ruijie Gao, Chenying Lu, Jiansong Ji
OBJECTIVES: To investigate the relationship between baseline computed tomography perfusion deficit volumes and functional outcomes in patients with basilar artery occlusion (BAO) undergoing endovascular therapy. METHODS: This was a single-center study in which the data of 64 patients with BAO who underwent endovascular therapy were retrospectively analyzed. All the patients underwent multi-model computed tomography on admission. The posterior-circulation Acute Stroke Prognosis Early Computed Tomography Score was applied to assess the ischemic changes...
March 7, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38460466/acute-aortic-occlusion-a-narrative-review-for-emergency-clinicians
#36
REVIEW
Jessica Pelletier, Alex Koyfman, Brit Long
INTRODUCTION: Acute aortic occlusion (AAO) is a rare but serious condition associated with significant morbidity and mortality. OBJECTIVE: This review provides an emergency medicine focused evaluation of AAO, including presentation, assessment, and emergency department (ED) management based on current evidence. DISCUSSION: AAO refers to obstruction of blood flow through the aorta due to either thrombosis or embolism. This condition primarily affects older adults ages 60-70 with cardiovascular comorbidities and most commonly presents with signs and symptoms of acute limb ischemia, though the gastrointestinal tract, kidneys, and spinal cord may be affected...
February 24, 2024: American Journal of Emergency Medicine
https://read.qxmd.com/read/38460429/monocyte-to-high-density-lipoprotein-ratio-as-an-independent-predictor-of-intracranial-atherosclerotic-stenosis-related-emergency-large-vessel-occlusion
#37
JOURNAL ARTICLE
Huangbin Lin, Hongjian Shen, Nuo Wang, Tao Wu
OBJECTIVE: To evaluate the correlation between the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) and intracranial atherosclerotic stenosis-related emergent large vessel occlusion (ICAS-ELVO) in acute ischemic stroke patients with endovascular thrombectomy. METHODS: Included in this study were 215 patients who underwent endovascular thrombectomy. They were randomly assigned to training and testing datasets. The patients in training dataset (n=128) were divided into ICAS group (n=65) and embolism group (n=63)...
March 6, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38459953/the-effectiveness-and-safety-of-human-urinary-kallidinogenase-in-acute-ischemic-stroke-patients-undergoing-endovascular-therapy
#38
JOURNAL ARTICLE
Mengmeng Wang, Changwei Guo, Jie Yang, Jing Li, Jinrong Hu, Zhouzhou Peng, Meng Guo, Lingyu Zhang, Fengli Li, Qingwu Yang, Wenjie Zi, Pengfei Wang
The effectiveness and safety of human urinary kallidinogenase (HUK) in acute ischemic stroke (AIS) patients undergoing endovascular therapy (EVT) due to large vessel occlusion (LVO) was unclear. A pooled analysis was performed using individual data from the DEVT and RESCUE BT trials. Patients were divided into two groups based on HUK treatment. The primary outcome was the 90-day modified Rankin Scale (mRS) score. Safety outcomes included 90-day mortality and symptomatic intracranial hemorrhage (sICH) within 48 hours...
March 9, 2024: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/38457578/unconsciousness-as-the-main-nonfocal-symptom-of-anterior-circulation-transient-ischemic-attack-a-case-report
#39
JOURNAL ARTICLE
Xiaomeng Dong, Ziliang Zhang, Bin Li, Wenbin Ma, Jinbo Chen, Yipeng Su
RATIONALE: Unconsciousness is a nonfocal symptom of transient ischemic attack (TIA) that is frequently observed in patients with vertebrobasilar artery stenosis or occlusion. Conversely, loss of consciousness due to anterior circulation involvement (e.g., middle cerebral artery [MCA]) is a rare occurrence in TIA. PATIENT CONCERNS: This report describes a rare case in a 59-year-old woman who experienced recurrent episodes of altered consciousness because of the occlusion or stenosis of her MCAs...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38457313/reduction-of-left-ventricular-diastolic-pressure-as-a-key-regulator-of-infarct-coronary-flow-under-mechanical-left-ventricular-support
#40
JOURNAL ARTICLE
Tomoki Sakata, Spyros A Mavropoulos, Renata Mazurek, Francisco J Romeo, Anjali J Ravichandran, Jonas M Marx, Taro Kariya, Kiyotake Ishikawa
Restoring ischaemic myocardial tissue perfusion is crucial for minimizing infarct size. Acute mechanical left ventricular (LV) support has been suggested to improve infarct tissue perfusion. However, its regulatory mechanism remains unclear. We investigated the physiological mechanisms in six Yorkshire pigs, which were subjected to 90-min balloon occlusion of the left anterior descending artery. During the acute reperfusion phase, LV support using an Impella heart pump was initiated. LV pressure, coronary flow and pressure of the infarct artery were simultaneously recorded to evaluate the impact of LV support on coronary physiology...
March 8, 2024: Journal of Physiology
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