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https://www.readbyqxmd.com/read/29666943/the-gtn-patch-a-simple-and-effective-new-approach-to-cardioprotection
#1
Derek M Yellon, Zhenhe He, Rayomand Khambata, Amrita Ahluwalia, Sean M Davidson
There remains a significant un-met need to reduce the extent of myocardial injury caused by ischaemia and reperfusion injury in patients experiencing an ST-elevation MI. Although nitric oxide is central to many cardioprotective strategies currently undergoing investigation, cardioprotection from the delivery of nitrates/nitrites has been inconsistently observed. The route of administration appears to be a critical variable. The glyceryl trinitrate (GTN) patch is commonly used as a simple and practical means of delivering nitric oxide to patients with ischaemic heart disease, but whether acute cardioprotection can be achieved by application of a GTN patch has not been investigated before...
April 17, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29666905/balloon-occluded-carbon-dioxide-gas-angiography-for-internal-iliac-arteriography-and-intervention
#2
Mitsuhiro Kishino, Shuichiro Nakaminato, Yoshio Kitazume, Naoyuki Miyasaka, Toshifumi Kudo, Yukihisa Saida, Ukihide Tateishi
INTRODUCTION: The usefulness of carbon dioxide (CO2 ) gas digital subtraction angiography (DSA) has been reported for patients with renal insufficiency and allergy to iodinated contrast agents. However, CO2 gas cannot replace the iodinated contrast agent in all cases owing to some disadvantages. We describe balloon-occluded CO2 DSA (B-CO2 DSA) as an improved CO2 DSA procedure for interventions in the internal iliac artery (IIA) region and compare the quality of images obtained using conventional CO2 DSA and B-CO2 DSA...
April 17, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29666180/thrombectomy-for-acute-ischemic-stroke-in-the-elderly-a-real-world-experience
#3
Ali Alawieh, Arindam Chatterjee, Wuwei Feng, Guilherme Porto, Jan Vargas, Ryan Kellogg, Aquilla S Turk, Raymond D Turner, M Imran Chaudry, Alejandro M Spiotta
INTRODUCTION: Completed randomized trials on endovascular thrombectomy (ET) did not independently assess the efficacy of ET in the elderly (≥80 years old) who were often excluded or under-represented in trials. There were also inconsistent criteria for patient selection in this population across the different trials. This work evaluates outcomes after ET for acute ischemic stroke (AIS) in the elderly at a high volume stroke center. METHODS: We reviewed all cases of AIS that underwent a direct aspiration first pass technique (ADAPT) thrombectomy for large vessel occlusions between March 2013 and October 2017 while comparing outcomes in the elderly with younger counterparts...
April 17, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29665290/timely-visualization-of-the-collaterals-formed-during-acute-ischemic-stroke-with-fe-3-o-4-nanoparticle-based-mr-imaging-probe
#4
Ting Wang, Yi Hou, Bo Bu, Wenxin Wang, Tiancong Ma, Chunyan Liu, Lan Lin, Lin Ma, Xin Lou, Mingyuan Gao
Ischemic stroke is one of the major leading causes for long-term disability and mortality. Collateral vessels provide an alternative pathway to protect the brain against ischemic injury after arterial occlusion. Aiming at visualizing the collaterals occurring during acute ischemic stroke, an integrin αv β3 -specific Fe3 O4 -Arg-Gly-Asp (RGD) nanoprobe is prepared for magnetic resonance imaging (MRI) of the collaterals. Rat models are constructed by occluding the middle cerebral artery for imaging studies of cerebral ischemia and ischemia-reperfusion on 7...
April 17, 2018: Small
https://www.readbyqxmd.com/read/29663853/collateral-pial-circulation-relates-to-the-degree-of-brain-edema-on-ct-24-hours-after-ischemic-stroke
#5
Orlando Galego, Joana Jesus-Ribeiro, Mariana Baptista, João Sargento-Freitas, Ana Inês Martins, Fernando Silva, Gustavo Cordeiro Santos, Luís Cunha, César Nunes, Egídio Machado
Background Cerebral edema is frequent in patients with acute ischemic stroke (AIS) who undergo reperfusion therapy and is associated with high mortality. The impact of collateral pial circulation (CPC) status on the development of edema has not yet been determined. Methods We studied consecutive patients with AIS and documented M1-middle cerebral artery (MCA) and/or distal internal carotid artery (ICA) occlusion who underwent reperfusion treatment. Edema was graded on the 24-hour non-contrast computed tomography (NCCT) scan...
January 1, 2018: Neuroradiology Journal
https://www.readbyqxmd.com/read/29663204/-acute-visual-loss-following-central-retinal-vein-occlusion
#6
REVIEW
Isabel Görsch, C Haritoglou
No abstract text is available yet for this article.
April 2018: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/29662933/endometriosis-a-rare-cause-of-large-bowel-obstruction
#7
Gonçalo Alexandrino, Luís Carvalho Lourenço, Rita Carvalho, Cisaltina Sobrinho, David Valadas Horta, Jorge Reis
Large bowel obstruction can result in significant morbidity and mortality, especially in cases of acute complete obstruction. There are many possible causes, the most common in adults being colorectal cancer. Endometriosis is a benign disease, and the most affected extragenital location is the bowel, especially the rectosigmoid junction. However, transmural involvement and acute occlusion are very rare events. We report an exceptional case of acute large bowel obstruction as the initial presentation of endometriosis...
March 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29661662/multimodal-analysis-using-flowmeter-analysis-laser-doppler-spectrophotometry-and-indocyanine-green-videoangiography-for-the-detection-of-venous-compromise-in-flaps-in-rats
#8
Lucas M Ritschl, Leonard H Schmidt, Andreas M Fichter, Alexander Hapfelmeier, Klaus-Dietrich Wolff, Thomas Mücke
Venous congestion results in tissue damage and remains the most common failure of free microvascular transfer if it is not recognized early. The purpose of this experimental study was to evaluate venous congestion and describe the findings with two different monitoring tools. A standardized epigastric flap was raised, and total occlusion of the draining vein was temporarily applied for 4, 5, 6, or 7 h. Blood flow measurements, including laser-Doppler flowmetry, and tissue spectrophotometry (O2C) and indocyanine green (ICG) videoangiography using the FLOW® 800 tool, were performed systematically after each surgical step, an interval of venous occlusion, and 1 week of clinical observation...
March 30, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29661609/assessing-the-effect-of-an-educational-intervention-on-nurses-and-patient-care-assistants-comprehension-and-documentation-of-functional-ability-in-pediatric-patients-with-sickle-cell-disease
#9
Katherine M Bernier, Megan Strobel, Ruth Lucas
PURPOSE: In 2014, the Youth Acute Pain Functional Ability Questionnaire (YAPFAQ) was developed to investigate patient's self-rated functional ability during times of acute pain in the inpatient clinical setting. Although it has great potential, the application of this tool has not been made a standard of care. The purpose of this multiple methods study was to determine if, through an educational intervention, hospital staff could consistently document the YAPFAQ in children with sickle cell disease (SCD) during a vaso-occlusive episode...
April 13, 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29659846/is-administration-of-dual-antiplatelet-therapy-beneficial-for-patients-following-off-pump-coronary-artery-bypass-grafting
#10
Maciej Peksa, Sleiman Sebastian Aboul-Hassan, Jakub Marczak, Romuald Cichon
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether administration of dual-antiplatelet therapy (DAPT) following off-pump coronary artery bypass grafting (OPCAB) would improve postoperative clinical outcomes or minimize the incidence of postoperative graft failure. In total, 101 papers were found using the reported search, 14 of which represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated...
April 5, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29659089/recurrent-aortic-root-pseudoaneurysm-after-transcatheter-occlusion-a-word-of-caution
#11
Makoto Hibino, Yoshiaki Katada, Kentaro Shibayama, Kotaro Obunai, Hiroyuki Watanabe, Yuji Kawano, Shun Watanabe, Minoru Tabata
A 48-year-old male developed a recurrent aortic-root pseudoaneurysm after surgical repair for acute dissection. Although the initial closure of the pseudoaneurysm was successfully managed by transcatheter endovascular occlusion and coiling utilizing a hybrid transapical and transfemoral approach, the pseudoaneurysm was recanalized after 3 months and a third-time surgical repair was required. The potential risk for recurrence of pseudoaneurysms should be considered when applying endovascular occlusion devices to treat aortic root anatomy...
April 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29658678/emergency-surgery-for-bowel-obstruction-in-extremely-aged-patients
#12
Alberto Oldani, Valentina Gentile, Chiara Magaton, Marcello Calabrò, Fabio Maroso, Lidia Ravizzini, Giacomo Deiro, Maurizio Amato, Sergio Gentilli
BACKGROUND: As a result of the increasing of life expectancy, the incidence of pathologies that can lead to operation for bowel obstruction is also increasing. Comorbidities and reduced physiological reserve can decrease elderly patients' ability to tolerate operations especially in an emergency context. We retrospectively evaluated the treatment and outcomes of a cohort of patients aged more than 85 years who underwent emergency surgery for intestinal occlusion. METHODS: 278 patients who were admitted to our Institution and operated for acute bowel obstruction have been included in our study...
April 13, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29658326/cardioprotective-role-of-colchicine-against-inflammatory-injury-in-a-rat-model-of-acute-myocardial-infarction
#13
Oussama Bakhta, Simon Blanchard, Anne-Laure Guihot, Sophie Tamareille, Delphine Mirebeau-Prunier, Pascale Jeannin, Fabrice Prunier
BACKGROUND: Inflammation plays a crucial role in the pathophysiology of myocardial ischemia/reperfusion (I/R) injury. A clinical trial has recently reported a smaller infarct size in a cohort of patients with ST-segment elevation myocardial infarction (MI) treated with a short colchicine course. The mechanism underlying colchicine-induced cardioprotection in the early MI phase remains unclear. We hypothesized that a short pretreatment with colchicine could induce acute beneficial effects by protecting the heart against inflammation in myocardial I/R injury...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29658074/injection-of-multipotent-mesenchymal-stromal-cells-as-a-cause-of-hemorrhages-in-the-regional-lymph-nodes-experimental-study
#14
I V Maiborodin, V V Morozov, A A Anikeev, N F Figurenko, R V Maslov, V A Matveeva, V I Maiborodina
Hemorrhagic changes after subcutaneous injection of autologous bone marrow multipotent mesenchymal cells with transfected GFP gene and additionally stained cell membranes to WAG rats in the projection of ligated femoral vein were studied by fluorescent microscopy. Hemorrhages in tissues with experimental acute local venous occlusion were caused by a combination of venous hypertension with inflammation around the foreign body - the ligature used for ligation of the vein. Fibrin found in tissues together with erythrocytes in the hemorrhages could stimulate the formation of granulations and new vessels instead of damaged or thrombosed ones...
April 16, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29657723/accuracy-of-the-smaller-superior-mesenteric-vein-sign-for-the-detection-of-acute-superior-mesenteric-artery-occlusion
#15
Takaaki Nakano, Toshitaka Ito, Tetsuhiro Takei, Masaaki Takemoto
Aims: The smaller superior mesenteric vein (SMV) sign is a well-known computed tomography (CT) parameter for acute superior mesenteric artery (SMA) occlusion. This CT sign is potentially beneficial for the early diagnosis of acute SMA occlusion; however, few reports have documented this sign. The present study aimed to determine the accuracy of the smaller SMV sign for the detection of acute SMA occlusion. Methods: We retrospectively reviewed CT images from 20 patients with acute SMA occlusion and 1,216 controls...
April 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29652542/sympathoexcitation-constrains-vasodilation-in-the-human-skeletal-muscle-microvasculature-during-post-occlusive-reactive-hyperemia
#16
Masashi Ichinose, Mikie Nakabayashi, Yumie Ono
We used diffuse correlation spectroscopy (DCS) to investigate sympathetic vasoconstriction, local vasodilation, and integration of these two responses in the skeletal muscle microvasculature of 20 healthy volunteers. DCS probes were placed on the flexor carpi radialis muscle (FC) or the vastus lateralis muscle (VL), and a blood flow index (BFI) was derived continuously. We measured hemodynamic responses during sympathoexcitation induced by forehead cooling, after which the effects of the increased sympathetic tone on vasodilatory responses during post-occlusive reactive hyperemia (PORH) were examined...
April 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29651586/revascularization-techniques-for-acute-basilar-artery-occlusion-technical-considerations-and-outcome-in-the-setting-of-severe-posterior-circulation-steno-occlusive-disease
#17
Eberhard Siebert, Georg Bohner, Sarah Zweynert, Volker Maus, Anastasios Mpotsaris, Thomas Liebig, Christoph Kabbasch
PURPOSE: To describe the clinical and radiological characteristics, frequency, technical aspects and outcome of endovascular treatment of acute basilar artery occlusion (ABO) in the setting of vertebrobasilar steno-occlusive disease. METHODS: Retrospective analysis of databases of two universitary stroke centers including all consecutive patients from January 2013 until May 2017 undergoing thrombectomy for a) acute stroke due to basilar artery occlusion and either significant basilar artery stenosis or vertebral artery stenosis/occlusion as well as b) presumed embolic basilar artery occlusions...
April 12, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29651500/outcome-of-endovascular-treatment-for-acute-basilar-artery-occlusion-in-the-modern-era-a-single-institution-experience
#18
Chuanhui Li, Wenbo Zhao, Chuanjie Wu, Shuyi Shang, Jian Chen, Ming Ren, Jiangang Duan, Qingfeng Ma, Guilin Li, Yunzhou Zhang, Hongqi Zhang, Liqun Jiao, Xunming Ji
PURPOSE: The beneficial effect of endovascular treatment (EVT) for patients with acute basilar artery occlusion (ABAO) remains uncertain. The purpose of the present study was to evaluate clinical outcome of EVT for patients with ABAO and analyze prognostic factors of good outcome. METHODS: From our prospectively established database, we reviewed all patients with ABAO receiving EVT during January 2014 to December 2016. Baseline characteristics and outcomes were evaluated...
April 12, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29650782/treatment-of-distal-anterior-cerebral-artery-aneurysms-with-flow-diverter-stents-a-single-center-experience
#19
F Cagnazzo, M Cappucci, C Dargazanli, P-H Lefevre, G Gascou, C Riquelme, A Bonafe, V Costalat
BACKGROUND AND PURPOSE: Flow diversion for aneurysms beyond the circle of Willis is still debated. Our aim was to evaluate the safety and efficacy of flow diversion treatment of distal anterior cerebral artery aneurysms. MATERIALS AND METHODS: Consecutive patients with distal anterior cerebral artery aneurysms treated from January 2014 to October 2017 were evaluated retrospectively with prospectively maintained data. Treatment was performed only for unruptured or recanalized aneurysms after coiling...
April 12, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29650683/fda-approval-summary-mylotarg-for-treatment-of-patients-with-relapsed-or-refractory-cd33-positive-acute-myeloid-leukemia
#20
Kelly J Norsworthy, Chia-Wen Ko, Jee Eun Lee, Jiang Liu, Christy S John, Donna Przepiorka, Ann T Farrell, Richard Pazdur
On September 2, 2017, the U.S. Food and Drug Administration approved gemtuzumab ozogamicin (GO; Mylotarg; Pfizer, New York City, NY) for treatment of relapsed or refractory (R/R) CD33-positive acute myeloid leukemia (AML) in patients 2 years of age and older. GO is a CD33-directed antibody drug conjugate linked to the cytotoxic antibiotic calicheamicin. It originally received accelerated approval for treatment of older patients with relapsed CD33-positive AML in 2000, but it was withdrawn from the market in 2010 when the confirmatory trial failed to demonstrate clinical benefit among safety concerns, such as a higher rate of induction fatalities on the GO combination arm compared with chemotherapy alone...
April 12, 2018: Oncologist
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