J Marquard, A Welters, T Buschmann, W Barthlen, S Vogelgesang, D Klee, M Krausch, A Raffel, S Otter, L Piemonti, E Mayatepek, T Otonkoski, E Lammert, T Meissner
AIMS/HYPOTHESIS: Exercise-induced hyperinsulinism (EIHI) is a hypoglycaemic disorder characterised by inappropriate insulin secretion following anaerobic exercise or pyruvate load. Activating promoter mutations in the MCT1 gene (also known as SCLA16A1), coding for monocarboxylate transporter 1 (MCT1), were shown to associate with EIHI. Recently, transgenic Mct1 expression in pancreatic beta cells was shown to introduce EIHI symptoms in mice. To date, MCT1 has not been demonstrated in insulin-producing cells from an EIHI patient...
January 2013: Diabetologia