Christophe Huret, Léa Ferrayé, Antoine David, Myriame Mohamed, Nicolas Valentin, Frédéric Charlotte, Magali Savignac, Michele Goodhardt, Jean-Charles Guéry, Claire Rougeulle, Céline Morey
In mammals, males and females show marked differences in immune responses. Males are globally more sensitive to infectious diseases, while females are more susceptible to systemic autoimmunity. X-chromosome inactivation (XCI), the epigenetic mechanism ensuring the silencing of one X in females, may participate in these sex biases. We perturbed the expression of the trigger of XCI, the noncoding RNA Xist , in female mice. This resulted in reactivation of genes on the inactive X, including members of the Toll-like receptor 7 (TLR7) signaling pathway, in monocyte/macrophages and dendritic and B cells...
May 3, 2024: Science Advances